keyword
https://read.qxmd.com/read/38534166/early-gastric-signet-ring-cell-adenocarcinoma-as-a-flat-pale-patch-on-an-esophagogastroduodenoscopy
#1
JOURNAL ARTICLE
Will Takakura, Shanti Eswaran, William D Chey, Hiroya Ueyama, Richard Kwon, Andrea Todisco, Scott Owens, Elena Stoffel, Oxana V Crysler, Filip Bednar, Benjamin R Hart
No abstract text is available yet for this article.
March 27, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38457280/nurse-facilitated-5000%C3%A2-m-running-at-parkrun-improves-vulnerable-adolescent-health-in-a-high-deprivation-area-a-matched-pair-randomized-control-trial
#2
JOURNAL ARTICLE
Tiara R Williams, Rachael C Walker, Chey G Dearing
OBJECTIVE: To examine the effect of weekly nurse facilitated 5000 m running at Parkrun on markers of health in vulnerable adolescents from a high deprivation area. DESIGN: A matched pair randomized control trial. SAMPLE: Twenty-five adolescents aged 13-18, 90% identifying as Māori/Pasifika ethnicity. INTERVENTION: The intervention (INT) group participated in 6-10 Parkruns within 10 weeks, and a control group (CON) participated in one Parkrun only...
March 8, 2024: Public Health Nursing
https://read.qxmd.com/read/38294158/abdominal-symptom-improvement-during-clinical-trials-of-tenapanor-in-patients-with-irritable-bowel-syndrome-with-constipation-a-post-hoc-analysis
#3
JOURNAL ARTICLE
Anthony J Lembo, William D Chey, Lucinda A Harris, Rosita Frazier, Darren M Brenner, Lin Chang, Brian E Lacy, Susan Edelstein, Yang Yang, Suling Zhao, David P Rosenbaum
OBJECTIVES: This post hoc analysis evaluated the efficacy of tenapanor on abdominal symptoms in patients with irritable bowel syndrome with constipation (IBS-C). Abdominal symptoms assessed included pain, discomfort, bloating, cramping, and fullness. METHODS: The abdominal symptom data were pooled from 3 randomized controlled trials (NCT01923428, T3MPO-1 [NCT02621892], and T3MPO-2 [NCT02686138]). Weekly scores were calculated for each abdominal symptom, and the Abdominal Score (AS) was derived as the average of weekly scores for abdominal pain, discomfort, and bloating...
January 31, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38284690/percutaneous-electrical-nerve-field-stimulation-for-adolescents-with-irritable-bowel-syndrome-cost-benefit-and-cost-minimization-analysis
#4
JOURNAL ARTICLE
Eric Shah, Shanti Eswaran, Kimberly Harer, Allen Lee, Borko Nojkov, Prashant Singh, William D Chey
Abdominal pain drives significant cost for adolescents with irritable bowel syndrome (IBS). We performed an economic analysis to estimate cost-savings for patients' families and healthcare insurance, and health outcomes, based on abdominal pain improvement with percutaneous electrical nerve field stimulation (PENFS) with IB-Stim® (Neuraxis). We constructed a Markov model with a 1-year time horizon comparing outcomes and costs with PENFS versus usual care without PENFS. Clinical outcomes were derived from a sham-controlled double-blind trial of PENFS for adolescents with IBS...
January 15, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38173154/symptomatic-response-to-antibiotics-in-patients-with-small-intestinal-bacterial-overgrowth-a-systematic-review-and-meta-analysis
#5
Will Takakura, Ali Rezaie, William D Chey, Jiajing Wang, Mark Pimentel
BACKGROUND/AIMS: We performed a systematic review and meta-analysis evaluating the symptomatic response rate to antibiotics in patients with small intestinal bacterial overgrowth (SIBO). Similarly, we performed a meta-analysis on the symptomatic response to antibiotics in irritable bowel syndrome (IBS) patients with and without SIBO. METHODS: MEDLINE, EMBASE, Web of Science, and Cochrane databases were searched from inception to March 2021. Randomized controlled trials and prospective studies reporting dichotomous outcomes were included...
January 30, 2024: Journal of Neurogastroenterology and Motility
https://read.qxmd.com/read/37734345/optimizing-the-management-algorithm-for-adults-with-functional-constipation-failing-a-fiber-laxative-trial-in-general-gastroenterology-cost-effectiveness-and-cost-minimization-analysis
#6
JOURNAL ARTICLE
Eric D Shah, Nitin K Ahuja, Darren M Brenner, Walter W Chan, Michael A Curley, Judy Nee, Johanna Iturrino-Moreda, Kyle Staller, Sameer D Saini, William D Chey
INTRODUCTION: Anorectal function testing is traditionally relegated to subspecialty centers. Yet, it is an office-based procedure that appears capable of triaging care for the many patients with Rome IV functional constipation that fail empiric over-the-counter therapy in general gastroenterology, as an alternative to empirical prescription drugs. We aimed to evaluate cost-effectiveness of routine anorectal function testing in this specific population. METHODS: We performed a cost-effectiveness analysis from the patient perspective and a cost-minimization analysis from the insurer perspective to compare 3 strategies: (i) empiric prescription drugs followed by pelvic floor physical therapy (PFPT) for drug failure, (ii) empiric PFPT followed by prescription drugs for PFPT failure, or (iii) care directed by up-front anorectal function testing...
February 1, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/37668173/long-term-safety-of-tenapanor-in-patients-with-irritable-bowel-syndrome-with-constipation-in-the-t3mpo-3-study
#7
JOURNAL ARTICLE
Anthony J Lembo, Keith A Friedenberg, Ronald P Fogel, Susan Edelstein, Suling Zhao, Yang Yang, David P Rosenbaum, William D Chey
BACKGROUND: Tenapanor, a first-in-class, minimally systemic inhibitor of intestinal sodium/hydrogen exchanger isoform 3 (NHE3), is approved for the treatment of irritable bowel syndrome with constipation (IBS-C) in adults based on two randomized, placebo-controlled, phase III studies (T3MPO-1 [NCT02621892], T3MPO-2 [NCT02686138]). The open-label T3MPO-3 extension study (NCT02727751) enrolled patients who completed these studies to investigate long-term safety and tolerability of tenapanor...
September 5, 2023: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/37664485/efficacy-and-safety-of-naloxegol-in-patients-with-chronic-non-cancer-pain-who-experience-opioid-induced-constipation-a-pooled-analysis-of-two-global-randomized-controlled-studies
#8
JOURNAL ARTICLE
William D Chey, Darren M Brenner, Brooks D Cash, Martin Hale, Jeremy Adler, Mansi S Jamindar, Carol B Rockett, June S Almenoff, Enoch Bortey, Jeffrey Gudin
OBJECTIVE: This study evaluates the onset, magnitude, and consistency of improvement of opioid-induced constipation (OIC) symptoms with naloxegol treatment. METHODS: This was a pooled analysis of two Phase 3, double-blind, randomized, placebo-controlled studies (KODIAC-04/05, NCT01309841/NCT01323790) in patients with chronic non-cancer pain and OIC treated with naloxegol 25mg or 12.5mg daily. This analysis assessed improvements in response rates, frequency of spontaneous bowel movement (SBM) and complete SBMs (CSBM), OIC constipation symptoms (straining, stool consistency), time to first post-dose SBM and CSBM, and onset of adverse events over the 12-week period...
2023: Journal of Pain Research
https://read.qxmd.com/read/37595647/prevalence-and-burden-of-illness-of-rome-iv-irritable-bowel-syndrome-in-the-united-states-results-from-a-nationwide-cross-sectional-study
#9
JOURNAL ARTICLE
Christopher V Almario, Eden Sharabi, William D Chey, Marie Lauzon, Carolyn S Higgins, Brennan M R Spiegel
BACKGROUND & AIMS: The estimated prevalence of irritable bowel syndrome (IBS) using Rome IV criteria in the US ranges from 4.7% to 5.3%, although these estimates arise from studies with relatively small sample sizes. The aim of this study was to assess the prevalence of IBS and its associated burden of illness using a nationally representative dataset with nearly 89,000 people in the US. METHODS: From May 3 to June 24, 2020, we performed an online survey described to participating adults ≥18 years old as a "national health survey...
August 16, 2023: Gastroenterology
https://read.qxmd.com/read/37391055/a-randomized-parallel-group-study-of-digital-gut-directed-hypnotherapy-vs-muscle-relaxation-for-irritable-bowel-syndrome
#10
JOURNAL ARTICLE
Sameer K Berry, Rani Berry, David Recker, Jeffrey Botbyl, Lucy Pun, William D Chey
BACKGROUND & AIMS: Gut-directed hypnotherapy (GDH) is effective for treating irritable bowel syndrome (IBS), but access limits its widespread use. We report the first randomized controlled trial comparing the safety and efficacy of a self-administered, digital GDH treatment program with that of digital muscle relaxation (MR) in adults with IBS. METHODS: After a 4-week run-in period, patients were randomized to 12 weeks of treatment with digital GDH (Regulora), or digital MR accessed via a mobile app on a smartphone or tablet...
June 28, 2023: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/37388121/brief-communication-global-temporal-trends-in-the-efficacy-of-clarithromycin-based-regimens-for-the-treatment-of-helicobacter-pylori-infection
#11
JOURNAL ARTICLE
Steven F Moss, William D Chey, Patrick Daniele, Corey Pelletier, Rinu Jacob, Gabriel Tremblay, Elizabeth Hubscher, Eckhard Leifke, Peter Malfertheiner
BACKGROUND: Helicobacter pylori eradication rates achieved with clarithromycin-based triple therapies are declining due to antibiotic resistance, but data regarding temporal changes in efficacy with these eradication therapies are scarce. OBJECTIVE: To evaluate the efficacy of clarithromycin-based triple eradication regimens over time. DESIGN: A comprehensive literature review and time-trend analysis. DATA SOURCES AND METHODS: Bibliographies of recently published systematic literature reviews were searched and supplemented with a targeted literature review conducted using Medline and Embase databases and ProQuest from conception to May 2021...
2023: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/37335135/prevalence-and-burden-of-illness-of-rome-iv-chronic-idiopathic-constipation-opioid-induced-constipation-and-opioid-exacerbated-constipation-in-the-united-states
#12
JOURNAL ARTICLE
Jeff Liang, Christopher V Almario, William D Chey, Carolyn S Higgins, Brennan M R Spiegel
OBJECTIVES: Chronic idiopathic constipation (CIC) and opioid-induced constipation (OIC) are disorders that negatively impact quality of life. We sought to assess the prevalence, symptom severity, and medication use among people with Rome IV CIC, OIC, and opioid-exacerbated constipation (OEC) using a nationally representative dataset with nearly 89,000 people in the US. METHODS: From May 3 to June 24, 2020, we recruited a representative sample of people in the US ≥18yo to complete an online national health survey...
June 19, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/37302444/optimizing-the-utility-of-anorectal-manometry-for-diagnosis-and-therapy-a-roundtable-review-and-recommendations
#13
REVIEW
Satish S C Rao, Nitin K Ahuja, Adil E Bharucha, Darren M Brenner, William D Chey, Jill K Deutsch, David C Kunkel, Baharak Moshiree, Leila Neshatian, Robert M Reveille, Gregory S Sayuk, Jordan M Shapiro, Eric D Shah, Kyle Staller, Steven D Wexner, Jason R Baker
BACKGROUND & AIMS: Anorectal manometry (ARM) is a comprehensive diagnostic tool for evaluating patients with constipation, fecal incontinence, or anorectal pain; however, it is not widely utilized for reasons that remain unclear. The aim of this roundtable discussion was to critically examine the current clinical practices of ARM and biofeedback therapy by physicians and surgeons in both academic and community settings. METHODS: Leaders in medical and surgical gastroenterology and physical therapy with interest in anorectal disorders were surveyed regarding practice patterns and utilization of these technologies...
October 2023: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/37292648/the-fecal-microbiome-in-quiescent-crohn-s-disease-with-persistent-gastrointestinal-symptoms-show-enrichment-of-oral-microbes-but-depletion-of-butyrate-and-indole-producers
#14
Jonathan Golob, Krishna Rao, Jeffrey Berinstein, William Chey, Chung Owyang, Nobuhiko Kamada, Peter Higgins, Vincent Young, Shrinivas Bishu, Allen Lee
BACKGROUND AND AIMS: Even in the absence of inflammation, persistent symptoms in Crohn's disease (CD) are prevalent and negatively impact quality of life. We aimed to determine whether quiescent CD patients with persistent symptoms ( qCD+symptoms ) have changes in microbial structure and functional potential compared to those without symptoms ( qCD-symptoms ). METHODS: We performed a prospective multi-center observational study nested within the SPARC IBD study...
May 17, 2023: medRxiv
https://read.qxmd.com/read/37211380/american-gastroenterological-association-american-college-of-gastroenterology-clinical-practice-guideline-pharmacological-management-of-chronic-idiopathic-constipation
#15
JOURNAL ARTICLE
Lin Chang, William D Chey, Aamer Imdad, Christopher V Almario, Adil E Bharucha, Susan Diem, Katarina B Greer, Brian Hanson, Lucinda A Harris, Cynthia Ko, M Hassan Murad, Amit Patel, Eric D Shah, Anthony J Lembo, Shahnaz Sultan
INTRODUCTION: Chronic idiopathic constipation (CIC) is a common disorder associated with significant impairment in quality of life. This clinical practice guideline, jointly developed by the American Gastroenterological Association and the American College of Gastroenterology, aims to inform clinicians and patients by providing evidence-based practice recommendations for the pharmacological treatment of CIC in adults. METHODS: The American Gastroenterological Association and the American College of Gastroenterology formed a multidisciplinary guideline panel that conducted systematic reviews of the following agents: fiber, osmotic laxatives (polyethylene glycol, magnesium oxide, lactulose), stimulant laxatives (bisacodyl, sodium picosulfate, senna), secretagogues (lubiprostone, linaclotide, plecanatide), and serotonin type 4 agonist (prucalopride)...
June 2023: Gastroenterology
https://read.qxmd.com/read/37211024/overlap-of-disorders-of-gut-brain-interaction-a-systematic-review-and-meta-analysis
#16
JOURNAL ARTICLE
Thomas Fairlie, Ayesha Shah, Nicholas J Talley, William D Chey, Natasha Koloski, Yeong Yeh Lee, Kok-Ann Gwee, Michael P Jones, Gerald Holtmann
BACKGROUND: Rome criteria differentiate distinct types of disorders of gut-brain interaction (DGBI); also known as functional gastrointestinal disorders. Overlap of symptom categories frequently occurs. This systematic review and meta-analysis aimed to define the prevalence of DGBI overlap and compare overlap in population-based, primary care or tertiary care health settings. Furthermore, we aimed to compare symptom severity of psychological comorbidities in DGBI with and without overlap...
July 2023: Lancet. Gastroenterology & Hepatology
https://read.qxmd.com/read/37204227/american-gastroenterological-association-american-college-of-gastroenterology-clinical-practice-guideline-pharmacological-management-of-chronic-idiopathic-constipation
#17
JOURNAL ARTICLE
Lin Chang, William D Chey, Aamer Imdad, Christopher V Almario, Adil E Bharucha, Susan Diem, Katarina B Greer, Brian Hanson, Lucinda A Harris, Cynthia Ko, M Hassan Murad, Amit Patel, Eric D Shah, Anthony J Lembo, Shahnaz Sultan
INTRODUCTION: Chronic idiopathic constipation (CIC) is a common disorder associated with significant impairment in quality of life. This clinical practice guideline, jointly developed by the American Gastroenterological Association and the American College of Gastroenterology, aims to inform clinicians and patients by providing evidence-based practice recommendations for the pharmacological treatment of CIC in adults. METHODS: The American Gastroenterological Association and the American College of Gastroenterology formed a multidisciplinary guideline panel that conducted systematic reviews of the following agents: fiber, osmotic laxatives (polyethylene glycol, magnesium oxide, lactulose), stimulant laxatives (bisacodyl, sodium picosulfate, senna), secretagogues (lubiprostone, linaclotide, plecanatide), and serotonin type 4 agonist (prucalopride)...
June 1, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36898553/in-memoriam-william-y-chey-md-dsc-agaf-facg
#18
EDITORIAL
William D Chey
No abstract text is available yet for this article.
June 2023: Gastroenterology
https://read.qxmd.com/read/36822371/randomized-placebo-controlled-phase-3-trial-of-vibrating-capsule-for-chronic-constipation
#19
RANDOMIZED CONTROLLED TRIAL
Satish S C Rao, Eamonn M M Quigley, William D Chey, Amol Sharma, Anthony J Lembo
BACKGROUND & AIMS: Despite therapeutic advances, effective treatments for chronic constipation remain an unmet need. The vibrating capsule is a nonpharmacologic, orally ingested, programmable capsule that vibrates intraluminally to induce bowel movements. We aimed to determine the efficacy and safety of the vibrating capsule in patients with chronic constipation. METHODS: We conducted a phase 3, double-blind, placebo-controlled trial of patients with chronic constipation, who were randomized to receive either a vibrating or placebo capsule, once daily, 5 days a week for 8 weeks...
June 2023: Gastroenterology
https://read.qxmd.com/read/36799911/behavioral-health-digital-therapeutics-for-patients-with-irritable-bowel-syndrome-a-primer-for-gastroenterologists
#20
JOURNAL ARTICLE
Zachary M Saleh, William D Chey, Sameer K Berry
No abstract text is available yet for this article.
March 20, 2023: American Journal of Gastroenterology
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