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William Chey

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https://www.readbyqxmd.com/read/28555632/corrigendum-eluxadoline-efficacy-in-ibs-d-patients-who-report-prior-loperamide-use
#1
Brian E Lacy, William D Chey, Brooks D Cash, Anthony J Lembo, Leonard S Dove, Paul S Covington
This corrects the article DOI: 10.1038/ajg.2017.72.
May 30, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28417992/eluxadoline-efficacy-in-ibs-d-patients-who-report-prior-loperamide-use
#2
Brian E Lacy, William D Chey, Brooks D Cash, Anthony J Lembo, Leonard S Dove, Paul S Covington
OBJECTIVES: Irritable bowel syndrome with diarrhea (IBS-D) is often managed with over-the-counter therapies such as loperamide, though with limited success. This analysis evaluated the efficacy of eluxadoline in patients previously treated with loperamide in two phase 3 studies. METHODS: Adults with IBS-D (Rome III criteria) were enrolled and randomized to placebo or eluxadoline (75 or 100 mg) twice daily for 26 (IBS-3002) or 52 (IBS-3001) weeks. Patients reported loperamide use over the previous year and recorded their rescue loperamide use during the studies...
June 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28244678/introduction
#3
William D Chey
No abstract text is available yet for this article.
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28244495/tenapanor-treatment-of-patients-with-constipation-predominant-irritable-bowel-syndrome-a-phase-2-randomized-placebo-controlled-efficacy-and-safety-trial
#4
William D Chey, Anthony J Lembo, David P Rosenbaum
OBJECTIVES: Tenapanor is a first-in-class, small-molecule inhibitor of the gastrointestinal sodium/hydrogen exchanger NHE3. This study assessed the efficacy and safety of tenapanor in patients with constipation-predominant irritable bowel syndrome (IBS-C). METHODS: In this phase 2, double-blind study, patients with IBS-C (Rome III criteria) were randomized (1:1:1:1) to receive tenapanor 5 mg, 20 mg, or 50 mg b.i.d., or placebo b.i.d. for 12 weeks. The primary end point was the complete spontaneous bowel movement (CSBM) responder rate, defined as the proportion of patients reporting an increase from baseline of ≥1 CSBM/week for ≥6/12 treatment weeks...
May 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28174125/family-history-in-colonoscopy-patients-feasibility-and-performance-of-electronic-and-paper-based-surveys-for-colorectal-cancer-risk-assessment-in-the-outpatient-setting
#5
Tannaz Guivatchian, Erika S Koeppe, Jason R Baker, Cristina Moisa, Matthew Demerath, Caitlin Foor-Pessin, William D Chey, Shanti L Eswaran, Joseph C Kolars, Stacy B Menees, Michael Rajala, Michael D Rice, Rafat Rizk, Joel H Rubenstein, Pratima Sharma, Andrea Todisco, Elena M Stoffel
BACKGROUND AND AIMS: Family history is crucial in stratifying patients' risk for colorectal cancer (CRC). Previous risk assessment tools developed for use in clinic or endoscopy settings have demonstrated suboptimal specificity for identifying patients with hereditary cancer syndromes. Our aim was to test the feasibility and performance of 2 family history surveys (paper and electronic) in individuals presenting for outpatient colonoscopy. METHODS: Patients presenting for outpatient colonoscopy at a tertiary care center were asked to complete a 5 question paper risk assessment survey (short paper survey) either alone or in conjunction with a second, comprehensive electronic family risk assessment survey (comprehensive tablet survey)...
February 4, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28071659/acg-clinical-guideline-treatment-of-helicobacter-pylori-infection
#6
William D Chey, Grigorios I Leontiadis, Colin W Howden, Steven F Moss
Helicobacter pylori (H. pylori) infection is a common worldwide infection that is an important cause of peptic ulcer disease and gastric cancer. H. pylori may also have a role in uninvestigated and functional dyspepsia, ulcer risk in patients taking low-dose aspirin or starting therapy with a non-steroidal anti-inflammatory medication, unexplained iron deficiency anemia, and idiopathic thrombocytopenic purpura. While choosing a treatment regimen for H. pylori, patients should be asked about previous antibiotic exposure and this information should be incorporated into the decision-making process...
February 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27913997/mega-cecum-an-unrecognized-cause-of-symptoms-in-some-female-patients-with-uro-gynecological-symptoms-and-severe-slow-transit-constipation
#7
William Y Chey, Vincent Chang, Cameron M Hoellrich, Kae Yol Lee, Maxine Lubkin, Deborah Corcoran, Ta-Min Chang, William D Chey
BACKGROUND: A subset of female patients with severe constipation report overlapping uro-gynecological symptoms which have been attributed to visceral hypersensitivity. AIMS: To study colon morphology and motor function in female patients with medically refractory chronic constipation with or without uro-gynecological symptoms and to assess clinical outcomes following laparoscopic ileo-proctostomy. METHODS: Colon anatomy and cecal emptying time were assessed with plain films and fluoroscopy following a standardized test meal mixed with barium...
December 2, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27753436/screening-for-celiac-disease-in-irritable-bowel-syndrome-an-updated-systematic-review-and-meta-analysis
#8
REVIEW
Andrew J Irvine, William D Chey, Alexander C Ford
OBJECTIVES: Celiac disease (CD) and irritable bowel syndrome (IBS) share similar symptoms, leading to confusion between the two and diagnostic delay. International guidelines recommend screening individuals with IBS for CD, via serological testing. However, studies published recently have cast doubt on the utility of this. We updated a previous meta-analysis examining this issue. METHODS: MEDLINE, EMBASE, and EMBASE Classic were searched through to May 2016. Eligible studies recruited adults with IBS according to symptom-based criteria, physician's opinion, or questionnaire data...
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27725652/a-randomized-controlled-trial-comparing-the-low-fodmap-diet-vs-modified-nice-guidelines-in-us-adults-with-ibs-d
#9
Shanti L Eswaran, William D Chey, Theresa Han-Markey, Sarah Ball, Kenya Jackson
OBJECTIVES: There has been an increasing interest in the role of fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) in irritable bowel syndrome (IBS). We report results from the first randomized controlled trial of the low FODMAP diet in US adults with IBS and diarrhea (IBS-D). The objectives were to compare the efficacy of the low FODMAP diet vs. a diet based upon modified National Institute for Health and Care Excellence guidelines (mNICE) on overall and individual symptoms in IBS-D patients...
December 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27680987/fermented-fiber-supplements-are-no-better-than-placebo-for-a-laxative-effect
#10
Johnson W McRorie, William D Chey
BACKGROUND: Misconceptions about the effects of dietary fiber and 'functional' fiber on stool parameters and constipation persist in the literature. METHODS: A comprehensive literature review was conducted with the use of the Scopus and PubMed scientific databases to identify and objectively assess well-controlled clinical studies that evaluated the effects of fiber on stool parameters and constipation. RESULTS: The totality of well-controlled randomized clinical studies show that, to exert a laxative effect, fiber must: (1) resist fermentation to remain intact throughout the large bowel and present in stool, and (2) significantly increase stool water content and stool output, resulting in soft/bulky/easy-to-pass stools...
November 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27599641/dietary-guidelines-for-irritable-bowel-syndrome-are-important-for-gastroenterologists-dietitians-and-people-with-irritable-bowel-syndrome
#11
William D Chey, Kevin Whelan
No abstract text is available yet for this article.
October 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/27585957/assessing-the-asymptomatic-reservoir-and-dihydroartemisinin-piperaquine-effectiveness-in-a-low-transmission-setting-threatened-by-artemisinin-resistant-plasmodium-falciparum
#12
Grégoire Falq, Rafael Van Den Bergh, Martin De Smet, William Etienne, Chea Nguon, Huy Rekol, Mallika Imwong, Arjen Dondorp, Jean-Marie Kindermans
BACKGROUND: In Cambodia, elimination of artemisinin resistance through direct elimination of the Plasmodium falciparum parasite may be the only strategy. Prevalence and incidence at district and village levels were assessed in Chey Saen district, Preah Vihear province, North of Cambodia. Molecular and clinical indicators for artemisinin resistance were documented. METHODS: A cross sectional prevalence survey was conducted at village level in the district of Chey Saen from September to October 2014...
September 1, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27501174/primary-pancreatic-secretinoma-further-evidence-supporting-secretin-as-a-diarrheogenic-hormone
#13
William Y Chey, Wendy L Frankel, Sashwati Roy, Soma Datta, Chandan K Sen, Mary Dillhoff, Peter Muscarella, Konrad H Soergel, Ronald K Tompkins, Ta-Min Chang, Edward L Bradley, Edwin Christopher Ellison
OBJECTIVES: To document the existence of primary pancreatic secretinoma in patients with watery diarrhea syndrome (WDS) and achlorhydria and establish secretin as a diarrheogenic hormone. BACKGROUND: Vasoactive intestinal peptide (VIP) has been widely accepted as the main mediator of WDS. However, in 1968, Zollinger et al reported 2 female patients with pancreatic neuroendocrine tumors, WDS, and achlorhydria. During surgery on the first, a 24-year-old patient, they noticed distended duodenum filled with fluid and a dilated gallbladder containing dilute bile with high bicarbonate concentration...
August 5, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27144634/rome-iv-diagnostic-questionnaires-and-tables-for-investigators-and-clinicians
#14
Olafur S Palsson, William E Whitehead, Miranda A L van Tilburg, Lin Chang, William Chey, Michael D Crowell, Laurie Keefer, Anthony J Lembo, Henry P Parkman, Satish Sc Rao, Ami Sperber, Brennan Spiegel, Jan Tack, Stephen Vanner, Lynn S Walker, Peter Whorwell, Yunsheng Yang
The Rome IV Diagnostic Questionnaires were developed to screen for functional gastrointestinal disorders (FGIDs), serve as inclusion criteria in clinical trials, and support epidemiological surveys. Separate questionnaires were developed for adults, children/adolescents, and infants/toddlers. For the adult questionnaire, we first surveyed 1,162 adults without gastrointestinal disorders, and recommended the 90(th) percentile symptom frequency as the threshold for defining what is abnormal. Diagnostic questions were formulated and verified with clinical experts using a recursive process...
February 13, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27144627/bowel-disorders
#15
Fermín Mearin, Brian E Lacy, Lin Chang, William D Chey, Anthony J Lembo, Magnus Simren, Robin Spiller
Functional bowel disorders are highly prevalent disorders found worldwide. These disorders have the potential to affect all members of society, regardless of age, gender, race, creed, color or socioeconomic status. Improving our understanding of functional bowel disorders (FBD) is critical as they impose a negative economic impact to the global health care system in addition to reducing quality of life. Research in the basic and clinical sciences during the past decade has produced new information on the epidemiology, etiology, pathophysiology, diagnosis and treatment of FBDs...
February 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/26932837/artificial-sweeteners-a-systematic-review-and-primer-for-gastroenterologists
#16
REVIEW
Marisa Spencer, Amit Gupta, Lauren Van Dam, Carol Shannon, Stacy Menees, William D Chey
Artificial sweeteners (AS) are ubiquitous in food and beverage products, yet little is known about their effects on the gastrointestinal (GI) tract, and whether they play a role in the development of GI symptoms, especially in patients with irritable bowel syndrome. Utilizing the PubMed and Embase databases, we conducted a search for articles on individual AS and each of these terms: fermentation, absorption, and GI tract. Standard protocols for a systematic review were followed. At the end of our search, we found a total of 617 eligible papers, 26 of which were included...
April 30, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/26925880/breath-testing-for-small-intestinal-bacterial-overgrowth-a-means-to-enrich-rifaximin-responders-in-ibs-patients
#17
Amit Gupta, William D Chey
No abstract text is available yet for this article.
March 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/26856749/food-the-main-course-to-wellness-and-illness-in-patients-with-irritable-bowel-syndrome
#18
REVIEW
William D Chey
Food sits at the intersection between gastrointestinal (GI) physiology and symptoms in patients with the irritable bowel syndrome (IBS). It is now clear that the majority of IBS sufferers associate eating a meal with their GI and non-GI symptoms. This is hardly surprising when one considers that food can affect a variety of physiologic factors (motility, visceral sensation, brain-gut interactions, microbiome, permeability, immune activation, and neuro-endocrine function) relevant to the pathogenesis of IBS...
March 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/26717902/timothy-t-nostrant-md-macg-october-20-1947-october-2-2015
#19
EDITORIAL
William D Chey, Chung Owyang
No abstract text is available yet for this article.
February 2016: Gastroenterology
https://www.readbyqxmd.com/read/26673504/response-to-sorrentino-et-al
#20
LETTER
Stacy Menees, Corey Powell, William D Chey
No abstract text is available yet for this article.
December 2015: American Journal of Gastroenterology
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