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Peng-Xiang Pei, Jing-Han Hu, Chen Long, Peng-Wei Ni
A novel chemosensor 2-((Z)-(((E)-quinolin-2-ylmethylene)hydrazono)methyl)phenol PX has been successfully designed and synthesized, which showed both colorimetric and "turn-on" fluorescence responses for CN- in DMSO/H2 O (3:2, v/v; pH=7.20) solution. The sensor could respond effectively to the stimulation of CN- ions via deprotonation and sensing mechanism of intramolecular charge transfer (ICT). Moreover, the sensor PX was successfully utilized to detect CN- in bitter almond, and the detection limit on fluorescence response of PX towards CN- was down to 4...
March 10, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Cheng Jin, Jianjiang Feng, Lei Wang, Heng Yu, Jiang Liu, Jiwen Lu, Jie Zhou
In this paper, we present an approach for left atrial appendage (LAA) multi-phase fast segmentation and quantitative assisted diagnosis of atrial fibrillation (AF) based on 4D-CT data. We take full advantage of the temporal dimension information to segment the living, flailed LAA based on a parametric max-flow method and graph-cut approach to build 3-D model of each phase. To assist the diagnosis of AF, we calculate the volumes of 3-D models, and then generate a "volume-phase" curve to calculate the important dynamic metrics: ejection fraction, filling flux, and emptying flux of the LAA's blood by volume...
March 9, 2018: Computers in Biology and Medicine
Meryem Mniouil, Hajiba Fellah, Fatima Amarir, Abderrahim Sadak, Abdeslam Et-Touys, Youssef Bakri, Aziza Moustachi, Fatima Zahraa Tassou, Mostapha Hida, Mohamed Lyagoubi, El Bachir Adlaoui, Mohamed Rhajaoui, Faiza Sebti
A rapid, sensitive and specific tool for detection of Leishmania infantum infection in Humans would be highly desirable, because it would allow control interventions in endemic areas of visceral leishmaniasis. This study was carried out at the Reference National Laboratory of Leishmaniasis (RNLL) in National Institute of Hygiene (NIH) Morocco, in order to evaluate the diagnostic potential of immunochromatographic dipstick test (ICT) rk39 in Moroccan suspected VL patients. A total of 49 admitted patients with strong clinical suspicion of VL and 40 healthy controls were investigated for the performance of the ICT rk39...
March 12, 2018: Acta Tropica
Yuly Vesga, Carlos Diaz, Jeanne Crassous, Florencio E Hernandez
Herein, we report on the theoretical-experimental analysis of the two photon absorption and circular dichroism spectra of 1-(2-pyridyl)-4-methoxy-carbo[6]helicene derivative (P6). The primary outcomes of our investigation on this particular helicene derivative with a donor-acceptor motif on one end led to two important conclusions: 1) The lengthening of the π-electron delocalization within the helical core of P6 predominantly increases the contribution of the magnetic transition dipole moment to the TPCD signal; 2) The electric transition quadrupole moment contribution to the TPCD signal is enhanced by the intramolecular charge transfer (ICT) produced by the donor-acceptor combination on one end of the molecule...
March 15, 2018: Journal of Physical Chemistry. A
Yan Wu, Yaojun Jiang, Xueli Han, Mingyue Wang, Jianbo Gao
Background: To investigate the repeatability and accuracy of quantitative CT (QCT) measurement of bone mineral density (BMD) by low-mAs using iterative model reconstruction (IMR) technique based on phantom model. Methods: European spine phantom (ESP) was selected and measured on the Philips Brilliance iCT Elite FHD machine for 10 times. Data were transmitted to the QCT PRO workstation to measure BMD (mg/cm3 ) of the ESP (L1, L2, L3). Scanning method: the voltage of X-ray tube is 120 kV, the electric current of X-ray tube output in five respective groups A-E were: 20, 30, 40, 50 and 60 mAs...
February 2018: Quantitative Imaging in Medicine and Surgery
Elliot B Tapper, Neehar D Parikh, Akbar K Waljee, Michael Volk, Noelle E Carlozzi, Anna S-F Lok
OBJECTIVES: Minimal hepatic encephalopathy (HE) is common, characterized by deficits in reaction time and executive function, and strongly associated with disability and mortality. Point-of-care diagnostics performed without specialized skills or equipment are now available, albeit with limited data regarding their generalizability. METHODS: We systematically reviewed MEDLINE, EMBASE, Cochrane Library, and Scopus for diagnostic studies of MHE using broad search terms including HE and minimal, covert, or the names of published diagnostic modalities...
March 13, 2018: American Journal of Gastroenterology
Emma V Lampard, Adam C Sedgwick, Xiaolong Sun, Katherine L Filer, Samantha C Hewins, Gyoungmi Kim, Juyoung Yoon, Steven D Bull, Tony D James
In this work, we synthesized a series of boronate ester fluorescence probes ( E )-4,4,5,5-tetramethyl-2-(4-styrylphenyl)-1,3,2-dioxaborolane ( STBPin) , ( E )- N , N -dimethyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)styryl)aniline ( DSTBPin) , ( E )-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)styryl)benzonitrile ( CSTBPin) , ( E )-2-(4-(4-methoxystyryl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ( MSTBPin) , ( E )- N , N -dimethyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)styryl)naphthalen-1-amine ( NDSTBPin ), and N , N -dimethyl-4-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxazol-5-yl)aniline ( DAPOX-BPin ) for the detection of hydrogen peroxide (H2 O2 )...
March 2018: ChemistryOpen
C E Oude Weernink, L Sweegers, L Relou, T J van der Zijpp, J van Hoof
INTRODUCTION: Modern healthcare, including nursing home care, goes together with the use of technologies to support treatment, the provision of care and daily activities. The challenges concerning the implementation of such technologies are numerous. One of these emerging technologies are location technologies (RTLS or Real-Time Location Systems). that can be utilized in the nursing home for monitoring the use and location of assets. METHODOLOGY: This paper describes a participatory design study of RTLS based on context mapping, conducted in two nursing home organizations...
February 6, 2018: Technology and Disability
Aileen L Bergström, Elizabeth Hanson
BACKGROUND: A growing number of studies of informal carers of older people reveal positive results concerning support via Information and Communication Technologies (ICT). Systematic examination of factors that have a potential impact on carer outcomes are needed to inform future research. OBJECTIVE: To explore studies concerning ICT support of adult carers of older people and to identify study characteristics that have a potential impact on carer outcomes. METHODS: This integrative review includes 123 studies published since 2005...
February 5, 2018: Technology and Disability
Hongcheng Gao, Yu Gao, Cong Wang, Dehua Hu, Zengqi Xie, Linlin Liu, Bing Yang, Yuguang Ma
A new way to approaching highly emissive BODIPY dyes in both solution and solid state is achieved by introducing intramolecular charge transfer (ICT). A hybrid excited state that shows behaviors of both the ICT excited state and local excited state is discovered to be beneficial in avoiding the disturbance from the rotation vibration of the flexible phenyl substituents. Thus, the nonradiative transition process is suppressed, and the fluorescence efficiency goes up. By modification of the excited state, we realize emission enhancement of crystalline BODIPY derivatives with a PLQY from 0...
March 8, 2018: ACS Applied Materials & Interfaces
Yue Li, Liqiang Liu, Shanshan Song, Hua Kuang, Chuanlai Xu
Increasing attention is now being directed to the utilization of polymyxin B (PMB) as a last-line treatment for life-threatening infections caused by multidrug resistant Gram-negative bacteria. Unfortunately, polymyxins resistance is also increasingly reported, leaving a serious threat to human health. Therefore, the establishment of rapid detection methods for PMB residues is highly essential to ensure public health. In this study, two monoclonal antibodies (mAb; 2A2 and 3C6) were obtained using PMB-bovine serum albumin as the immunogen and PMB-ovalbumin as the coating antigen, which were prepared with N -(γ-maleimidobutyryloxy) succinimide ester and glutaraldehyde as cross-linking agents, respectively...
March 5, 2018: Nanomaterials
Dragana Dekanski, Biljana Spremo-Potparević, Vladan Bajić, Lada Živković, Dijana Topalović, Dušan N Sredojević, Vesna Lazić, Jovan M Nedeljković
The acute toxicity of surface-modified TiO2 nanoparticles (NPs) with caffeic acid (CA) was compared with those of its separate constituents (free CA and bare TiO2 NPs) upon their oral administration in laboratory mice. Prior to in vivo experiments, the interfacial charge transfer (ICT) complex between surface Ti atoms and CA is thoroughly characterized. Composition and stability constants of ICT complex were determined using Job's method and Banesi-Hildebrand analysis, respectively. The experimental data were supported with quantum chemical calculations based on density functional theory (DFT)...
March 3, 2018: Food and Chemical Toxicology
Dora Buonfrate, Paola Rodari, Daniele Brunelli, Monica Degani, Andrea Ragusa, Stefano Tais, Martina Todeschini, Zeno Bisoffi
BACKGROUND: An immunochromatographic rapid test (ICT; Schistosoma ICT IgG-IgM, LDBIO Diagnostics) demonstrated high sensitivity (96%) in the diagnosis of Schistosoma mansoni and S. haematobium . To date, the test has been validated for use on serum only, but in the absence of lab equipment, blood drop from fingerprick could be a useful option. This method is acquiring more interest because of the high flow of migrants rapidly moving across Italy and other European countries. OBJECTIVE: The aim of this prospective study was to evaluate the use of ICT on whole blood obtained from fingerprick...
March 3, 2018: BMJ Open
Aida Isabel Tavares
This work contributes to the discussion on the relationship between ICT and ehealth solutions in primary care, and self-reported health and health status in the European Union. The method used is an ordinary least squares linear model. The results show that there is no significant relation between self-reported health outcomes and ICT and ehealth indexes, except for self-reported chronic health problems. The more advanced that countries are in ICT, the larger is the share of people reporting a chronic health problem...
April 2018: International Journal of Medical Informatics
Robert G West, David Bína, Marcel Fuciman, Valentyna Kuznetsova, Radek Litvín, Tomáš Polívka
We have applied femtosecond transient absorption spectroscopy in pump-probe and pump-dump-probe regimes to study energy transfer between fucoxanthin and Chl a in fucoxanthin-Chl a complex from the pennate diatom Phaeodactylum tricornutum. Experiments were carried out at room temperature and 77 K to reveal temperature dependence of energy transfer. At both temperatures, the ultrafast (<100 fs) energy transfer channel from the fucoxanthin S2 state is active and is complemented by the second pathway via the combined S1 /ICT state...
February 27, 2018: Biochimica et Biophysica Acta
Onita Bhattasali, Jeannie Han, Lester D R Thompson, Gary L Buchschacher, Iman A Abdalla, Shawn Iganej
OBJECTIVE: The addition of induction chemotherapy (ICT) to concurrent chemoradiation (CCRT) has been investigated as a method of improving outcomes among patients with locally advanced head and neck squamous cell carcinoma. Previous studies have consisted of heterogeneous populations with both p16-positive and p16-negative disease and varying extent of nodal disease burden. We evaluated the role of ICT in p16-positive oropharyngeal squamous cell carcinoma (OPSCC) at high-risk of distant failure...
March 2018: Oral Oncology
Agustín Zaballos, Joan Navarro, Ramon Martín De Pozuelo
Information and communication technologies (ICTs) have enabled the evolution of traditional electric power distribution networks towards a new paradigm referred to as the smart grid. However, the different elements that compose the ICT plane of a smart grid are usually conceived as isolated systems that typically result in rigid hardware architectures, which are hard to interoperate, manage and adapt to new situations. In the recent years, software-defined systems that take advantage of software and high-speed data network infrastructures have emerged as a promising alternative to classic ad hoc approaches in terms of integration, automation, real-time reconfiguration and resource reusability...
February 28, 2018: Sensors
Mathieu Bangert, María D Flores-Chávez, Ivonne P Llanes-Acevedo, Carolina Arcones, Carmen Chicharro, Emilia García, Sheila Ortega, Javier Nieto, Israel Cruz
BACKGROUND: Visceral leishmaniasis (VL), the most severe form of leishmaniasis, is endemic in Europe with Mediterranean countries reporting endemic status alongside a worrying northward spread. Serological diagnosis, including immunochromatographic test based on the recombinant antigen rK39 (rK39-ICT) and a direct agglutination test (DAT) based on the whole parasite antigen, have been validated in regions with high VL burden, such as eastern Africa and the Indian subcontinent. To date, no studies using a large set of patients have performed an assessment of both methods within Europe...
March 1, 2018: PLoS Neglected Tropical Diseases
Philip Boucher, Susana Nascimento, Mariachiara Tallacchini
In ubiquitous surveillance societies, individuals are subjected to observation and control by authorities, institutions, and corporations. Sometimes, citizens contribute their own knowledge and other resources to their own surveillance. In addition, some of "the watched" observe "the watchers" "through" sous-veillant activities, and various forms of self-surveillance for different purposes (Lyon, D. [Ed.]. (2007) Surveillance studies: An overview. Cambridge, Polity.). However, information and communication technologies are also increasingly used for social initiatives with a bottom up structure where citizens themselves define the goals, shape the outcomes and profit from the benefits of watching activities...
February 28, 2018: Science and Engineering Ethics
Quinton J Meisner, Joseph V Accardo, Guoxiang Hu, Ronald J Clark, De-En Jiang, Lei Zhu
The structural and optical properties of hydroxyphenyl-substituted-1,2,3-triazole molecules ("click" triazoles) are described. "Click" triazoles are prepared from the copper(I)-catalyzed azide-alkyne cycloaddition reactions. The alkyne-derived C4 substituent of a "click" triazole engages in electronic conjugation more effectively with the triazolyl core than the azide-derived N1 substituent. Furthermore, triazolyl group exerts a stronger electron-withdrawing effect on the N1 than the C4 substituent...
February 28, 2018: Journal of Physical Chemistry. A
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