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https://www.readbyqxmd.com/read/28623353/the-efficacy-and-toxicities-of-intensive-induction-chemotherapy-followed-by-concurrent-chemoradiotherapy-in-nasopharyngeal-carcinoma-patients-with-n3-disease
#1
Yingying Zhang, Mingqiu Chen, Cheng Chen, Lin Kong, Jiade J Lu, Benhua Xu
To assess the feasibility, efficacy and safety of 4 cycles of induction chemotherapy (ICT) followed by concurrent chemoradiotherapy (CRT) in nasopharyngeal carcinoma (NPC) patients with N3 disease. ICT consisting of paclitaxel (135 mg/m(2)) and nedaplatin (80 mg/m(2)) given every 3 weeks for 4 cycles followed by cisplatin-based CRT was planned. 22 patients completed 4 cycles of TP regimen ICT and the CRT according to the protocol. After 4 cycles of ICT, the ORR of the primary site was 100% (CR 22.7%, PR 77...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28622892/a-phase-ii-trial-of-induction-nab-paclitaxel-and-cisplatin-followed-by-concurrent-chemoradiotherapy-in-patients-with-locally-advanced-nasopharyngeal-carcinoma
#2
Liang-Ru Ke, Wei-Xiong Xia, Wen-Ze Qiu, Xin-Jun Huang, Ya-Hui Yu, Hu Liang, Guo-Ying Liu, Yan-Qun Xiang, Xiang Guo, Xing Lv
OBJECTIVES: Nanoparticle albumin-bound paclitaxel (NAB-paclitaxel) was designed to avoid solvent-related toxicities, and improve anti-tumor efficacy via increasing paclitaxel's intratumoral concentration and its uptake by tumor cells. This trial aimed to determine the safety and efficacy of induction NAB-paclitaxel combined with cisplatin followed by concurrent chemoradiotherapy (CCRT) in patients with locally advanced nasopharyngeal carcinoma (LA-NPC). PATIENTS AND METHODS: Patients with stage III-IVb NPC received NAB-paclitaxel (260mg/m(2)) combined with cisplatin (80mg/m(2)) intravenously on days 1 and 22, followed by cisplatin (80mg/m(2)) on days 43 and 64, concomitant with intensity-modulated radiation therapy...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28621629/endoscopic-endonasal-odontoid-resection-with-real-time-intraoperative-image-guided-computed-tomography-report-of-4-cases
#3
Harminder Singh, Sarang Rote, Ajit Jada, Evan D Bander, Gustavo J Almodovar-Mercado, Walid I Essayed, Roger Härtl, Vijay K Anand, Theodore H Schwartz, Jeffrey P Greenfield
The authors present 4 cases in which they used intraoperative CT (iCT) scanning to provide real-time image guidance during endonasal odontoid resection. While intraoperative CT has previously been used as a confirmatory test after resection, to the authors' knowledge this is the first time it has been used to provide real-time image guidance during endonasal odontoid resection. The operating room setup, as well as the advantages and pitfalls of this approach, are discussed. A mobile intraoperative CT scanner was used in conjunction with real-time craniospinal neuronavigation in 4 patients who underwent endoscopic endonasal odontoidectomy for basilar invagination...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28615988/identification-and-control-of-an-isolated-but-intense-focus-of-lymphatic-filariasis-on-satawal-island-federated-states-of-micronesia-in-2003
#4
Moses Pretrick, Wayne Melrose, Jean-Paul Chaine, Deon Canyon, Jaime Carron, Patricia M Graves, Richard S Bradbury
BACKGROUND: There is very limited data available on the prevalence of Bancroftian filariasis in the Federated States of Micronesia (FSM). Considerable attempts to eliminate the disease had occurred in the Pacific region by the year 2003, and the prevalence in FSM was thought to be sufficiently low that the region was considered non-endemic. However, a survey conducted in 2003 on an isolated atoll of FSM, Satawal Island, challenged that assumption. METHODS: Participants on Satawal Island were recruited and their blood tested for Wuchereria bancrofti antigen by the filariasis immunochromatographic test (ICT) card and circulating microfilaria by Knott's concentration technique...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28614483/-public-health-impact-of-a-remote-diagnosis-system-implemented-in-regional-and-district-hospitals-in-paraguay
#5
Pedro Galván, Miguel Velázquez, Gualberto Benítez, José Ortellado, Ronald Rivas, Antonio Barrios, Enrique Hilario
Objective: Determine the viability of a remote diagnosis system implemented to provide health care to remote and scattered populations in Paraguay. Methods: The study was conducted in all regional and general hospitals in Paraguay, and in the main district hospitals in the country's 18 health regions. Clinical data, tomographic images, sonography, and electrocardiograms (ECGs) of patients who needed a diagnosis by a specialized physician were entered into the system...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28609505/creation-of-a-zone-of-immobile-connective-tissue-with-acellular-dermal-matrix-allografts
#6
Ramzi V Abou-Arraj, Maninder Kaur, Philip J Vassilopoulos, Nicolaas C Geurs
Acellular dermal matrix allografts (ADMs) have been hypothesized to create a zone of immobile connective tissue (ICT) extending apical to the mucogingival junction (MGJ). This 12-month prospective randomized trial investigated the presence of ICT after the use of two commercially available ADMs with coronally advanced flaps in the treatment of Miller Class I and II recession defects. This study demonstrated that the use of either type of ADM resulted in predictable root coverage and a zone of ICT extending apical to the MGJ by 1...
July 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28606894/developing-a-curriculum-for-information-and-communications-technology-use-in-global-health-research-and-training-a-qualitative-study-among-chinese-health-sciences-graduate-students
#7
Zhenyu Ma, Li Yang, Lan Yang, Kaiyong Huang, Hongping Yu, Huimin He, Jiaji Wang, Le Cai, Jie Wang, Hua Fu, Lisa Quintiliani, Robert H Friedman, Jian Xiao, Abu S Abdullah
BACKGROUND: Rapid development of information and communications technology (ICT) during the last decade has transformed biomedical and population-based research and has become an essential part of many types of research and educational programs. However, access to these ICT resources and the capacity to use them in global health research are often lacking in low- and middle-income country (LMIC) institutions. OBJECTIVE: The aim of our study was to assess the practical issues (ie, perceptions and learning needs) of ICT use among health sciences graduate students at 6 major medical universities of southern China...
June 12, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28603444/the-art-of-living-with-nzt-and-ict-dialectics-of-an-artistic-case-study
#8
EDITORIAL
Hub Zwart
I wholeheartedly sympathize conceptually with Coeckelbergh's paper. The dialectical relationship between vulnerability and technology constitutes the core of Hegel's Master and Slave (the primal scene of contemporary philosophy). Yet, the empirical dimension is underdeveloped and Coeckelbergh's ideas could profit from exposure to case studies. Building on a movie/novel (Limitless) devoted to vulnerability coping and living with ICT, I challenge the claim that modern heroism entails overcoming vulnerability with the help of enhancement and computers...
2017: Foundations of Science
https://www.readbyqxmd.com/read/28603438/social-autonomy-and-heteronomy-in-the-age-of-ict-the-digital-pharmakon-and-the-dis-empowerment-of-the-general-intellect
#9
Pieter Lemmens
'The art of living with ICTs (information and communication technologies)' today not only means finding new ways to cope, interact and create new lifestyles on the basis of the new digital (network) technologies individually, as 'consumer-citizens'. It also means inventing new modes of living, producing and, not in the least place, struggling collectively, as workers and producers. As the so-called digital revolution unfolds in the context of a neoliberal cognitive and consumerist capitalism, its 'innovations' are predominantly employed to modulate and control both production processes and consumer behavior in view of the overall goal of extracting surplus value...
2017: Foundations of Science
https://www.readbyqxmd.com/read/28602054/the-role-of-consolidation-chemo-radiotherapy-in-locally-advanced-pancreatic-cancer-receiving-chemotherapy-an-updated-systematic-review-and-meta-analysis
#10
Jeffrey S Chang, Yen-Feng Chiu, Jih-Chang Yu, Li-Tzong Chen, Hui-Ju Ch'ang
Purpose: The role of consolidation chemoradiation (CCRT) after systemic chemotherapy in locally advanced pancreatic cancer (LAPC) is still controversial. We aim to evaluate the effectiveness of CCRT in LAPC using systematic review and meta-analysis of prospective studies. Materials and Methods: Prospective clinical trials of LAPC receiving chemotherapy with or without subsequent CCRT were included in the analysis. We systematically searched in PubMed, Medline, Embase, Web of Science...
June 9, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28602027/assistive-technology-for-memory-support-in-dementia
#11
REVIEW
Henriëtte G Van der Roest, Jennifer Wenborn, Channah Pastink, Rose-Marie Dröes, Martin Orrell
BACKGROUND: The sustained interest in electronic assistive technology in dementia care has been fuelled by the urgent need to develop useful approaches to help support people with dementia at home. Also the low costs and wide availability of electronic devices make it more feasible to use electronic devices for the benefit of disabled persons. Information Communication Technology (ICT) devices designed to support people with dementia are usually referred to as Assistive Technology (AT) or Electronic Assistive Technology (EAT)...
June 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28601874/accuracy-of-intraoperative-computed-tomography-during-deep-brain-stimulation-procedures-comparison-with-postoperative-magnetic-resonance-imaging
#12
Maarten Bot, Pepijn van den Munckhof, Roy Bakay, Glenn Stebbins, Leo Verhagen Metman
OBJECTIVE: To determine the accuracy of intraoperative computed tomography (iCT) in localizing deep brain stimulation (DBS) electrodes by comparing this modality with postoperative magnetic resonance imaging (MRI). BACKGROUND: Optimal lead placement is a critical factor for the outcome of DBS procedures and preferably confirmed during surgery. iCT offers 3-dimensional verification of both microelectrode and lead location during DBS surgery. However, accurate electrode representation on iCT has not been extensively studied...
June 10, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28600902/transfer-of-innovation-on-allergic-rhinitis-and-asthma-multimorbidity-in-the-elderly-macvia-aria-reference-site-twinning-eip-on-aha
#13
J Bousquet, I Agache, M R Aliberti, R Angles, I Annesi-Maesano, J M Anto, S Arnavielhe, E Asayag, E Bacci, A Bedbrook, C Bachert, I Baroni, B A Barreto, M Bedolla-Barajas, K C Bergmann, L Bertorello, M Bewick, T Bieber, S Birov, C Bindslev-Jensen, A Blua, M Bochenska Marciniak, I Bogus-Buczynska, S Bosnic-Anticevich, I Bosse, R Bourret, C Bucca, R Buonaiuto, D Caiazza, D Caillot, D P Caimmi, P Camargos, G Canfora, V Cardona, A M Carriazo, C Cartier, G Castellano, N H Chavannes, M M Ciaravolo, C Cingi, A Ciceran, L Colas, E Colgan, J Coll, D Conforti, J Correira de Sousa, R M Cortés-Grimaldo, F Corti, E Costa, A L Courbis, E Cousein, A A Cruz, A Custovic, B Cvetkovski, C Dario, M da Silva, Y Dauvilliers, F De Blay, T Dedeu, G De Feo, B De Martino, P Demoly, G De Vries, S Di Capua Ercolano, N Di Carluccio, M Doulapsi, G Dray, R Dubakiene, E Eller, R Emuzyte, J M Espinoza-Contreras, A Estrada-Cardona, J Farrell, J Ferrero, W J Fokkens, J Fonseca, J F Fontaine, S Forti, J L Gálvez-Romero, C I García-Cobas, M H Garcia Cruz, B Gemicioğlu, R Gerth van Wijk, M Guidacci, J Gómez-Vera, N A Guldemond, Z Gutter, T Haahtela, J Hajjam, P W Hellings, L Hernández-Velázquez, M Illario, J C Ivancevich, E Jares, G Joos, J Just, O Kalayci, A F Kalyoncu, J Karjalainen, T Keil, N Khaltaev, L Klimek, V Kritikos, I Kull, P Kuna, V Kvedariene, V Kolek, E Krzych-Fałta, M Kupczyk, P Lacwik, D Larenas-Linnemann, D Laune, D Lauri, J Lavrut, M Lessa, G Levato, L Lewis, I Lieten, A Lipiec, R Louis, J A Luna-Pech, A Magnan, J Malva, J F Maspero, J J Matta-Campos, O Mayora, M A Medina-Ávalos, E Melén, E Menditto, J Millot-Keurinck, G Moda, M Morais-Almeida, R Mösges, A Mota-Pinto, J Mullol, A Muraro, R Murray, M Noguès, M Nalin, L Napoli, H Neffen, R E O'Hehir, G Onorato, S Palkonen, N G Papadopoulos, G Passalacqua, J L Pépin, A M Pereira, M Persico, O Pfaar, A C Pozzi, E Prokopakis, F Raciborski, J Rimmer, J A Rizzo, C Robalo-Cordeiro, M Rodríguez-González, G Rolla, R E Roller-Wirnsberger, A Romano, M Romano, J Salimäki, B Samolinski, F S Serpa, S Shamai, M Sierra, M Sova, M Sorlini, C Stellato, R Stelmach, T Strandberg, V Stroetmann, R Stukas, A Szylling, R Tan, V Tibaldi, A Todo-Bom, S Toppila-Salmi, P Tomazic, U Trama, M Triggiani, A Valero, E Valovirta, A Valiulis, M van Eerd, T Vasankari, A Vatrella, M T Ventura, M T Verissimo, F Viart, S Williams, M Wagenmann, C Wanscher, M Westman, M Wickman, I Young, A Yorgancioglu, E Zernotti, T Zurbierber, A Zurkuhlen, B De Oliviera, A Senn
The overarching goals of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) are to enable European citizens to lead healthy, active and independent lives while ageing. The EIP on AHA includes 74 Reference Sites. The aim of this study is to transfer innovation from an App developed by the MACVIA-France EIP on AHA reference site (Allergy Diary) to other reference sites. The phenotypic characteristics of rhinitis and asthma multimorbidity in adults and the elderly will be compared using validated information and communication technology (ICT) tools (i...
June 10, 2017: Allergy
https://www.readbyqxmd.com/read/28599762/co-teaching-exploring-an-alternative-for-integrated-curriculum
#14
Sadhana Sharma, Ravikirti, Asgar Ali, Roshan Takhelmayum, Mala Mahto, Rathish Nair
PURPOSE: Currently, the curriculum of medical education is compartmentalized which makes achieving the expected outcome, a real challenge. Co-teaching, an existing concept in education, however, may be used in medical education for integrating the applied component while basic concepts are being taught. The hypothesis, "can co-teaching be an alternate for an integrated curriculum?" was explored in this study. Therefore, the present study was designed to compare the outcomes of co-teaching with the existing teaching methodology owing to the absence of integrated curriculum...
July 2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28592727/temporal-sequential-pattern-of-right-ventricular-free-wall-contraction-in-normal-children
#15
Yasunobu Hayabuchi, Akemi Ono, Yukako Homma, Shoji Kagami
BACKGROUND: The temporal sequence of right ventricular (RV) deformation is related to RV dysfunction. The sequence of RV free wall contraction was investigated.Methods and Results:In this prospective study, strain profiles using speckle-tracking echocardiography and tissue Doppler-derived pulmonary and tricuspid annular motion were assessed in 60 normal children. Circumferential RV free wall strain of 3 individual segments (anterior, lateral, and inferior) was evaluated. Longitudinal strain was assessed in 3 individual segments (RV outflow tract [RVOT], apical, and RV inflow tract [RVIT])...
June 6, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28592353/role-of-information-and-communication-technology-in-promoting-oral-health-at-residential-aged-care-facilities
#16
Bola Adebayo, Angela Durey, Linda M Slack-Smith
Information and communication technology (ICT) can provide knowledge and clinical support to those working in residential aged care facilities (RACFs). This paper aims to: (1) review literature on ICT targeted at residents, staff and external providers in RACFs including general practitioners, dental and allied health professionals on improving residents' oral health; (2) identify barriers and enablers to using ICT in promoting oral health at RACFs; and (3) investigate evidence of effectiveness of these approaches in promoting oral health...
June 8, 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/28589432/comparative-efficacy-and-toxicity-of-induction-chemotherapy-with-concurrent-stereotactic-body-radiotherapy-and-stereotactic-body-radiotherapy-with-subsequent-chemotherapy-in-patients-with-clinical-stage-t1-3n0m0-non-small-cell-lung-carcinoma
#17
Y Sun, Q Duan, X Chen, W Chen, X Jin, R Wu
PURPOSE: We compared the clinical efficacy and toxicity of stereotactic body radiotherapy with induction chemotherapy and concurrent radiochemotherapy vs stereotactic body radiotherapy with subsequent chemotherapy in patients with clinical stage T1-3N0M0 non-small cell lung carcinoma. METHODS: We retrospectively analyzed 38 patients with c-stage T1-3N0M0 non-small cell lung carcinoma who received stereotactic body radiotherapy. All patients received six cycles of chemotherapy...
June 6, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28587457/unsymmetrical-and-symmetrical-push-pull-phenothiazines
#18
Yogajivan Rout, Prabhat Gautam, Rajneesh Misra
A series of unsymmetrical and symmetrical push-pull phenothiazines (3-7) were designed and synthesized by the Pd-catalyzed Sonogashira cross-coupling reaction and subsequent [2 + 2] cycloaddition-retroelectrocyclization reaction with tetracyanoethylene (TCNE) and 7,7,8,8-tetracyanoquinodimethane (TCNQ). The effect of systematic variation of the number and nature of cyano-based acceptor TCNE and TCNQ units on the photophysical, electrochemical, and computational studies was investigated. The single-photon absorption on phenothiazines 3-7 reveals that substitution of 1,1,4,4-tetracyanobutadiene (TCBD) and a cyclohexa-2,5-diene-1,4-diylidene-expanded TCBD unit results in strong intramolecular charge transfer and lowering of the LUMO energy level...
June 13, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28586942/-drawing-up-a-guideline-for-handling-information-and-communication-technology-flexibility-and-availability-in-small-and-medium-enterprises
#19
Veronika Weilnhammer, Stefanie Heinze, Barbara Heiden, Esther Palm, Britta Herbig, Gabriele Lüke, Dennis Nowak, Jürgen Glaser, Caroline Eva Wella Herr
Background Within the last decades the world of work has changed enormously. Due to new Information and Communication Technologies (ICT), working at any time from any place has become possible. Flexibility, availability and the dissolution of boundaries between work and private life are the possible results of this development. The spread of this development and possible consequences on the affected employee's health and wellbeing have been examined so far especially in big companies. Small and medium-sized enterprises (SME) are rarely subjects of scientific studies in this context...
June 6, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28583905/health-app-possession-among-smartphone-or-tablet-owners-in-hong-kong-population-based-survey
#20
Chen Shen, Man Ping Wang, Joanna Tw Chu, Alice Wan, Kasisomayajula Viswanath, Sophia Siu Chee Chan, Tai Hing Lam
BACKGROUND: Health apps are increasingly used with important implications for health. Hong Kong is one of the most technologically advanced and connected cities-smartphone ownership and Internet access rates are among the highest in the world. OBJECTIVE: We investigated the prevalence of health app possession and related sociodemographic factors and health behaviors among smartphone or tablet owners in Hong Kong. METHODS: A territory-wide population-based dual (landline and mobile) telephone survey was conducted in 2016...
June 5, 2017: JMIR MHealth and UHealth
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