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https://www.readbyqxmd.com/read/28212653/coordination-between-primary-and-secondary-care-the-role-of-electronic-messages-and-economic-incentives
#1
Antonella La Rocca, Thomas Hoholm
BACKGROUND: In Norway, a government reform has recently been introduced to enhance coordination between primary and secondary care. This paper examines the effects of two newly introduced measures to improve the coordination: an ICT-based communication tool/standard and an economic incentive scheme. METHOD: This qualitative study is based primarily on 27 open-ended interviews. We interviewed nine employees at a hospital (the focal actor), 17 employees from seven different municipalities, and a representative of a Regional Health Authority...
February 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28202426/integrated-platform-for-home-services-using-new-products-and-services-for-senior-citizens-call-cnav-carsat-2015
#2
Michel Noguès, Daniel Laune, Delphine Paccard, Anne-Laure Coupet, Justine Millot-Keurinck, Narjis Bototo, Marine Bertrand, Jean Bousquet
This project is part of: i) the risks of ageing prevention policy of the French retirement and occupational health insurance agency of Languedoc Roussillon (Carsat-LR) and ii) the European innovation partnership on active and healthy ageing (EIP on AHA). It aims to support senior citizens who live independently and have been identified at risk of frailty on a social or health level. The purpose is to increase legibility as well as technical and financial access to innovations for vulnerable seniors who are remote from the digital era, through a multiservice user-friendly platform...
February 15, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28202000/safety-and-efficacy-of-lobaplatin-combined-with-5-fluorouracil-as-first-line-induction-chemotherapy-followed-by-lobaplatin-radiotherapy-in-locally-advanced-nasopharyngeal-carcinoma-preliminary-results-of-a-prospective-phase-ii-trial
#3
Liang-Ru Ke, Wei-Xiong Xia, Wen-Ze Qiu, Xin-Jun Huang, Jing Yang, Ya-Hui Yu, Hu Liang, Guo-Ying Liu, Yan-Fang Ye, Yan-Qun Xiang, Xiang Guo, Xing Lv
BACKGROUND: Due to improvements in imaging and radiological techniques as well as the use of chemotherapy, distant metastasis has become the predominant mode of treatment failure in patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Platinum-based systemic chemotherapy has shown survival benefits and is now the standard strategy for systemic therapy in patients with LA-NPC. Notably, the third-generation platinum reagent lobaplatin has shown anti-tumor effects in several solid tumors with lower incidences of gastrointestinal, hepatic and renal toxicity relative to other platinum drugs...
February 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28196791/use-of-information-and-communication-technologies-among-older-people-with-and-without-frailty-a-population-based-survey
#4
Niina Susanna Keränen, Maarit Kangas, Milla Immonen, Heidi Similä, Heidi Enwald, Raija Korpelainen, Timo Jämsä
BACKGROUND: Use of information and communication technologies (ICT) among seniors is increasing; however, studies on the use of ICT by seniors at the highest risk of health impairment are lacking. Frail and prefrail seniors are a group that would likely benefit from preventive nutrition and exercise interventions, both of which can take advantage of ICT. OBJECTIVE: The objective of the study was to quantify the differences in ICT use, attitudes, and reasons for nonuse among physically frail, prefrail, and nonfrail home-dwelling seniors...
February 14, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28192728/core-competency-requirements-among-extension-workers-in-peninsular-malaysia-use-of-borich-s-needs-assessment-model
#5
Sulaiman Umar, Norsida Man, Nolila Mohd Nawi, Ismail Abd Latif, Bahaman Abu Samah
The study described the perceived importance of, and proficiency in core agricultural extension competencies among extension workers in Peninsular Malaysia; and evaluating the resultant deficits in the competencies. The Borich's Needs Assessment Model was used to achieve the objectives of the study. A sample of 298 respondents was randomly selected and interviewed using a pre-tested structured questionnaire. Thirty-three core competency items were assessed. Instrument validity and reliability were ensured. The cross-sectional data obtained was analysed using SPSS for descriptive statistics including mean weighted discrepancy score (MWDS)...
February 6, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28192612/advantage-of-eu-3-doped-polystyrene-microspheres-compared-with-colloidal-gold-used-in-immunochromatographic-assays-for-the-detection-of-melamine-in-milk
#6
Yiwei Tang, Hong Zhang, Xiuying Liu, Evan Trofimchuk, Shaolong Feng, Tao Ma, Xue Gao, Shubing Fang, Xiaonan Lu
Colloidal gold and Eu(3+) -doped fluorescent microspheres were applied as labels to develop the immunochromatographic strips for detecting melamine in milk. Under the optimized condition, the visual detection limit of colloidal gold-immunochromatographic test strip (ICTS) was 150 μg/L of melamine in phosphate-buffered saline (PBS), although the visual detection limit of fluorescent nanoparticles (FN)-ICTS was 75 μg/L in PBS. As thermal acceleration test, FN-ICTS could be stored at 37 °C for at least 11 d before sample testing, but the color of the lines on colloidal gold-ICTS faded away after 7-d storage...
February 13, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28192137/a-strategic-approach-for-direct-recovery-and-stabilization-of-fusarium-sp-ict-sac1-cutinase-from-solid-state-fermented-broth-by-carrier-free-cross-linked-enzyme-aggregates
#7
Sandeep A Chaudhari, Rekha S Singhal
The major hurdles in commercial exploitation of cutinase (having both esterolytic and lipolytic activities) with potent industrial applications are its high production cost, operational instability and reusability. Although commercially available in immobilized form, its immobilization process (synthesis of support/carrier) makes it expensive. Herein we tried to address multiple issues of production cost, stability, and reusability, associated with cutinase. Waste watermelon rinds, an agroindustrial waste was considered as a cheap support for solid state fermentation (SSF) for cutinase production by newly isolated Fusarium sp...
February 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28191848/intriguing-indium-salen-complexes-as-multicolor-luminophores
#8
Seon Hee Lee, Nara Shin, Sang Woo Kwak, Kyunglim Hyun, Won Hee Woo, Ji Hye Lee, Hyonseok Hwang, Min Kim, Junseong Lee, Youngjo Kim, Kang Mun Lee, Myung Hwan Park
The series of novel salen-based indium complexes (3-(t)Bu-5-R-salen)In-Me (3-(t)Bu-5-R-salen = N,N'-bis(2-oxy-3-tert-butyl-5-R-salicylidene)-1,2-diaminoethane, R = H (1), (t)Bu (2), Br (3), Ph (4), OMe (5), NMe2 (6)) and [(3-(t)Bu-5-NMe3-salen)In-Me](OTf)2 (7; OTf = CF3SO3(-)) have been synthesized and fully characterized by NMR spectroscopy and elemental analysis. All indium complexes 1-7 are highly stable in air and even aqueous solutions. The solid-state structures for 3-5, which were confirmed by single-crystal X-ray analysis, exhibit square-pyramidal geometries around the indium center...
February 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28186071/complex-clinical-communication-practices-how-do-information-receivers-assimilate-and-act-upon-information-for-patient-care
#9
Ming Chao Wong, Kwang Chien Yee, Paul Turner
Improving clinical communication is imperative to improving the quality and safety of patient care. Significant efforts have been made to improve clinical communication and patient safety, guided by the mantra of "the right information, to the right person, in the right place, at the right time". The design and implementation of information communication technologies (ICTs) has been considered as one of the major developments in improving patient care. Clinical communication in today's clinical practice is complex and involves multi-disciplinary teams using different types of media for information transfer...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28186052/designing-novel-health-icts-to-support-work-not-generate-it-five-principles
#10
David Peddie, Serena Small, Maeve Wickham, Chantelle Bailey, Corinne Hohl, Ellen Balka
In this paper, we offer five principles to inform how health ICT designers and healthcare organizations address and mitigate issues relating to clinician documentation burden. We draw on our experience and empirical work designing an ICT intervention, ActionADE, to illustrate how our team developed and will use these principles to ease documentation burden for clinician-users.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28185958/characterisation-of-aggregates-of-cyclodextrin-drug-complexes-using-taylor-dispersion-analysis
#11
Hadar Zaman, Andrew G Bright, Kevin Adams, David M Goodall, Robert T Forbes
There is a need to understand the nature of aggregation of cyclodextrins (CDs) with guest molecules in increasingly complex formulation systems. To this end an innovative application of Taylor dispersion analysis (TDA) and comparison with dynamic light scattering (DLS) have been carried out to probe the nature of ICT01-2588 (ICT-2588), a novel tumor-targeted vascular disrupting agent, in solvents including a potential buffered formulation containing 10% hydroxypropyl-β-cyclodextrin. The two hydrodynamic sizing techniques give measurement responses are that fundamentally different for aggregated solutions containing the target molecule, and the benefits of using TDA in conjunction with DLS are that systems are characterised through measurement of both mass- and z-average hydrodynamic radii...
February 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28183323/the-tech-home-study-a-technological-intervention-to-reduce-caregiver-burden-for-informal-caregivers-of-people-with-dementia-study-protocol-for-a-randomized-controlled-trial
#12
Agneta Malmgren Fänge, Steven M Schmidt, Maria H Nilsson, Gunilla Carlsson, Anna Liwander, Caroline Dahlgren Bergström, Paolo Olivetti, Per Johansson, Carlos Chiatti
BACKGROUND: It is estimated that global dementia rates will more than triple by 2050 and result in a staggering economic burden on families and societies. Dementia carries significant physical, psychological and social challenges for individuals and caregivers. Informal caregiving is common and increasing as more people with dementia are being cared for at home instead of in nursing homes. Caregiver burden is associated with lower perceived health, lower social coherence, and increased risk of morbidity and mortality...
February 9, 2017: Trials
https://www.readbyqxmd.com/read/28179176/peri-srs-administration-of-immune-checkpoint-therapy-for-melanoma-metastatic-to-the-brain-investigating-efficacy-and-the-effects-of-relative-treatment-timing-on-lesion-response
#13
Mehran B Yusuf, Mark J Amsbaugh, Eric Burton, Jason Chesney, Shiao Woo
OBJECTIVE(S): To investigate the efficacy of immune checkpoint therapy (ICT) administered with stereotactic radiosurgery (SRS) and determine the effects of relative treatment timing on lesion response. METHODS: A prospective institutional database of all patients with intact brain metastases treated with SRS from 2007 to 2015 was reviewed for patients diagnosed with malignant melanoma. Lesion response was determined using a modified RECIST v1.1 criteria. Patients were grouped according to if they received ICT and the timing of ICT relative to SRS...
February 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28165162/advanced-photosensitizers-based-on-orthogonal-bodipy-dimers-rational-design-to-finely-modulate-singlet-oxygen-generation
#14
Nerea Epelde-Elezcano, Eduardo Palao, Hegoi Manzano, Alejandro Prieto-Castañeda, Antonia R Agarrabeitia, Andrea Tabero, Angeles Villanueva, Santiago de la Moya, Iñigo López-Arbeloa, Virginia Martinez-Martinez, Maria J Ortiz
The synthesis, photophysical characterization and modelling of a new library of halogen-free photosensitizers (PS) based on orthogonal BODIPY dimers are reported. Herein we establish key structural factors to enhance singlet oxygen generation by judiciously chosen the substitution patterns attending to key electronic effects and synthetic accessibility factors. The photosensization mechanism of orthogonal BODIPY dimers is demonstrated to be strongly related to their intrinsic intramolecular charge transfer (ICT) character by SOCT-ISC (spin-orbit charge-transfer intersystem crossing) mechanism...
February 6, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28161327/unveiling-the-excited-state-energy-transfer-pathways-in-peridinin-chlorophyll-a-protein-by-ultrafast-multi-pulse-transient-absorption-spectroscopy
#15
Kipras Redeckas, Vladislava Voiciuk, Donatas Zigmantas, Roger G Hiller, Mikas Vengris
Time-resolved multi-pulse methods were applied to investigate the excited state dynamics, the interstate couplings, and the excited state energy transfer pathways between the light-harvesting pigments in peridinin-chlorophyll a-protein (PCP). The utilized pump-dump-probe techniques are based on perturbation of the regular PCP energy transfer pathway. The PCP complexes were initially excited with an ultrashort pulse, resonant to the S0→S2 transition of the carotenoid peridinin. A portion of the peridinin-based emissive intramolecular charge transfer (ICT) state was then depopulated by applying an ultrashort NIR pulse that perturbed the interaction between S1 and ICT states and the energy flow from the carotenoids to the chlorophylls...
February 2, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28160975/prescription-of-guideline-recommended-implantable-cardioverter-defibrillator-and-cardiac-resynchronization-therapy-among-patients-hospitalized-with-heart-failure-and-varying-degrees-of-renal-function
#16
Patrick H Pun, Shubin Sheng, Gillian Sanders, Adam D DeVore, Daniel Friedman, Gregg C Fonarow, Paul A Heidenreich, Clyde W Yancy, Adrian F Hernandez, Sana M Al-Khatib
Implantable cardioverter defibrillators (ICD) and cardiac resynchronization therapy (CRT) reduce mortality in many patients with heart failure (HF), but the current use and effectiveness of ICD/CRT in patients with chronic kidney disease (CKD) are uncertain. We examined associations between kidney function and guideline-recommended prescription of ICD/CRT in the Get With The Guidelines-Heart Failure registry, a performance improvement program for hospitalized patients with HF. We compared differences in ICD and CRT prescription between the following categories of estimated glomerular filtration rate (eGFR; mL/min/1...
December 18, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28159668/performance-analysis-of-two-immunochromatographic-assays-for-the-diagnosis-of-rotavirus-infection
#17
S De Grazia, F Bonura, A Pepe, S Li Muli, V Cappa, A Collura, D M Terranova, N Urone, F Di Bernardo, D Matranga, G M Giammanco
Group A rotaviruses (RVAs) are the primary cause of acute gastroenteritis (AGE) in young children worldwide. Several commercial tests including latex agglutination, enzyme-linked assays (ELISA) and immunochromatographic tests (ICT) have been developed for the diagnosis of RVA infection. In the present study, the performance of two commercially available one-step chromatographic immunoassays, CerTest Rotavirus+Adenovirus (Biotec S.L, Zaragoza, Spain) and Vikia Rota-Adeno (bioMerieux SA, Lyon, France) were retrospectively evaluated using Real-time PCR as reference test...
January 31, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28156010/refractoriness-to-immunochemotherapy-in-follicular-lymphoma-predictive-factors-and-outcome
#18
Marc Sorigue, Santiago Mercadal, Sara Alonso, Ruben Fernández-Álvarez, Olga García, Miriam Moreno, Helena Pomares, Miguel Alcoceba, Esther González-García, Cristina Motlló, Eva González-Barca, Alejandro Martin, Anna Sureda, Dolores Caballero, Josep-María Ribera, Juan-Manuel Sancho
Follicular lymphoma is characterized by a good response to immunochemotherapy (ICT). However, a small percentage of patients responds poorly to treatment and seems to have a worse outcome. This study attempted to identify the predictive factors and outcome of refractoriness to first-line ICT. All patients diagnosed with stage II to IV follicular lymphoma between 2002 and 2014 and treated with first-line ICT in 4 Spanish institutions were analyzed. Those with no response or progression or relapse within 6 months of first-line response assessment were considered ICT refractory...
February 3, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28155014/molecular-xenomonitoring-mx-and-transmission-assessment-survey-tas-of-lymphatic-filariasis-elimination-in-two-villages-menoufyia-governorate-egypt
#19
M A Moustafa, M M I Salamah, H S Thabet, R A Tawfik, M M Mehrez, D M Hamdy
Lymphatic filariasis (LF) is focally endemic in Egypt where the female mosquito, Culex pipiens, is responsible for its transmission. The aim of the study was to investigate the impact of implementation of the 13th round of MDA in two Egyptian villages in the Menoufyia Governorate area after failing the transmission assessment survey (TAS) in 2005 using two methods, and to decide whether it is safe to stop MDA in these, as well as in similar implementation units (IUs). To achieve this aim, both the immunochromatographic card test (ICT) and molecular xenomonitoring (MX) techniques were employed...
February 2, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28145632/design-synthesis-and-photovoltaic-characterization-of-a-small-molecular-acceptor-with-an-ultra-narrow-band-gap
#20
Huifeng Yao, Yong Cui, Runnan Yu, Bowei Gao, Hao Zhang, Jianhui Hou
The design of narrow band gap (NBG) donors or acceptors and their application in organic solar cells (OSCs) are of great importance in the conversion of solar photons to electrons. Limited by the inevitable energy loss from the optical band gap of the photovoltaic material to the open-circuit voltage of the OSC device, the improvement of the power conversion efficiency (PCE) of NBG-based OSCs faces great challenges. A novel acceptor-donor-acceptor structured non-fullerene acceptor is reported with an ultra-narrow band gap of 1...
February 1, 2017: Angewandte Chemie
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