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https://www.readbyqxmd.com/read/29775924/public-project-success-as-seen-in-a-broad-perspective-lessons-from-a-meta-evaluation-of-20-infrastructure-projects-in-norway
#1
Gro Holst Volden
Infrastructure projects in developed countries are rarely evaluated ex-post. Despite their number and scope, our knowledge about their various impacts is surprisingly limited. The paper argues that such projects must be assessed in a broad perspective that includes both operational, tactical and strategic aspects, and unintended as well as intended effects. A generic six-criteria evaluation framework is suggested, inspired by a framework frequently used to evaluate development assistance projects. It is tested on 20 Norwegian projects from various sectors (transport, defence, ICT, buildings)...
April 30, 2018: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29774897/development-of-highly-sensitive-fluorescent-probes-for-the-detection-of-%C3%AE-galactosidase-activity-application-to-the-real-time-monitoring-of-senescence-in-live-cells
#2
Mauro Safir Filho, Pascal Dao, Maéva Gesson, Anthony R Martin, Rachid Benhida
We report the development of four novel fluorescent probes to monitor the activity of the β-galactosidase enzyme (β-gal), in vitro and in living cells. The fluorophores are based on a 6-amino-styryl-benzothiazole push-pull core and display a strong ICT emission. The probes encompass the fluorescent motif that is connected to a β-d-galactopyranoside moiety through a self-immolative benzyl carbamate linker (βGal-1-4). The screening of four different fluorophores enabled us to access new light-up and two-band ratiometric reporters...
May 18, 2018: Analyst
https://www.readbyqxmd.com/read/29774296/integrated-risk-mapping-and-landscape-characterisation-of-lymphatic-filariasis-and-loiasis-in-south-west-nigeria
#3
Tara A Brant, Patricia N Okorie, Olushola Ogunmola, Nureni Bolaji Ojeyode, S B Fatunade, Emmanuel Davies, Yisa Saka, Michelle C Stanton, David H Molyneux, J Russell Stothard, Louise A Kelly-Hope
Nigeria has the heaviest burden of lymphatic filariasis (LF) in sub-Saharan Africa, which is caused by the parasite Wuchereria bancrofti and transmitted by Anopheles mosquitoes. LF is targeted for elimination and the national programme is scaling up mass drug administration (MDA) across the country to interrupt transmission. However, in some regions the co-endemicity of the filarial parasite Loa loa (loiasis) is an impediment due to the risk of severe adverse events (SAEs) associated with the drug ivermectin...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774165/multi-stimuli-responsive-luminescent-azepane-substituted-%C3%AE-diketones-and-difluoroboron-complexes
#4
Fang Wang, Christopher A DeRosa, Margaret L Daly, Daniel Song, Cassandra L Fraser
Difluoroboron β-diketonate (BF2 bdk) compounds show environment-sensitive optical properties in solution, aggregation-induced emission (AIE) and multi-stimuli responsive fluorescence switching in the solid state. Here, a series of 4-azepane-substituted β-diketone (bdk) ligands ( L-H , L-OMe , L-Br ) and their corresponding difluoroboron dyes ( D-H , D-OMe , D-Br ) were synthesized, and various responsive fluorescence properties of the compounds were studied, including solvatochromism, viscochromism, AIE, mechanochromic luminescence (ML) and halochromism...
September 1, 2017: Materials Chemistry Frontiers
https://www.readbyqxmd.com/read/29771966/the-effect-of-chronic-progressive-dose-sodium-bicarbonate-ingestion-on-crossfit-like-performance-a-double-blind-randomized-cross-over-trial
#5
Krzysztof Durkalec-Michalski, Emilia E Zawieja, Tomasz Podgórski, Igor Łoniewski, Bogna E Zawieja, Marta Warzybok, Jan Jeszka
BACKGROUND: Sodium bicarbonate (SB) has been proposed as an ergogenic aid, as it improves high-intensity and resistance exercise performance. However, no studies have yet investigated SB application in CrossFit. This study examined the effects of chronic, progressive-dose SB ingestion on CrossFit-like performance and aerobic capacity. METHODS: In a randomized, double-blind, cross-over trial, 21 CrossFit-trained participants were randomly allocated to 2 groups and underwent 2 trials separated by a 14-day washout period...
2018: PloS One
https://www.readbyqxmd.com/read/29767726/the-role-of-ethics-in-data-governance-of-large-neuro-ict-projects
#6
Bernd Carsten Stahl, Stephen Rainey, Emma Harris, B Tyr Fothergill
Objective: We describe current practices of ethics-related data governance in large neuro-ICT projects, identify gaps in current practice, and put forward recommendations on how to collaborate ethically in complex regulatory and normative contexts. Methods: We undertake a survey of published principles of data governance of large neuro-ICT projects. This grounds an approach to a normative analysis of current data governance approaches. Results: Several ethical issues are well covered in the data governance policies of neuro-ICT projects, notably data protection and attribution of work...
May 14, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29766913/telemedicine-and-neurosciences
#7
Krishnan Ganapathy
It is well documented that there is an acute shortage of neurologists and neurosurgeons in India and globally. Despite all efforts, it will be impossible to make available neurospecialists in all suburban and rural areas. Simultaneously, there has been an exponential increase in the growth and development of Information and Communication Technology (ICT). Plummeting costs and unbelievable sophistication in the availability of user-friendly mobile video conferencing devices is making distance meaningless. Geography has become History! Worldwide, the ultraconservative health care industry, in particular, the medical community, has been uniformly slow to adopt and embrace the use of ICT to extend their clinical reach...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29763669/travel-related-health-problems-in-the-immunocompromised-traveller-an-exploratory-study
#8
Mariëlle van Aalst, Marella C E van Ruissen, Roos Verhoeven, Godelieve J de Bree, Abraham Goorhuis, Martin P Grobusch
BACKGROUND: Immunocompromised travellers (ICTs) are at increased risk of travel-related health problems. Therefore, they are advised to attend specialised pre-travel clinics for advise on vaccination, malaria chemoprophylaxis and on demand antibiotics. However, studies yield conflicting data regarding travel-related health problems encountered by ICTs; questioning the rationale for certain advises, and particularly the advice of on demand antibiotics. OBJECTIVE: To evaluate self-reported travel-related health problems, antibiotic use, medical visits and risk behaviours in ICTs and controls...
May 12, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29761703/nonfullerene-acceptor-with-donor-acceptor-combined-%C3%AF-bridge-for-organic-photovoltaics-with-large-open-circuit-voltage
#9
Yang Yang, Jiacheng Wang, Han Xu, Xiaowei Zhan, Xingguo Chen
In this work, a kind of "D-A (Donor-Acceptor) combined pi-bridge" based on the regioselective reactivity of monofluoro-substituted benzothiadiazole (FBT) to link a thiophene ring has been designed to construct a new A-pi-D-pi-A type small molecular acceptor (IDT-FBTR) with indacenodithienothiophene (IDT) as a central core (D) and 3-octyl-2-(1,1-dicyanomethylene)rhodanine as an electron-withdrawing terminal group (A). Due to the strong intramolecular push-pull electron effect, IDT-FBTR shows a strong and broad intramolecular charge transfer (ICT) absorption band in the range of 500-750 nm...
May 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29759230/a-novel-near-infrared-fluorescent-probe-for-highly-selective-detection-of-cysteine-and-its-application-in-living-cells
#10
Wang Zhang, Jia Liu, Yuewen Yu, Qiaorong Han, Tian Cheng, Jian Shen, Bingxiang Wang, Yuliang Jiang
A novel red-emitting fluorescent probe (DDNA) for cysteine has been rationally designed and synthesized, which exhibited a low limit of detection to Cys (0.26 μM) as well as a favorable large stokes shift (λEm -λEx = 128 nm). This novel fluorophore (HDM), which features a large π-conjugation system and typical intramolecular charge transfer (ICT) process, has a long emission wavelength at 631 nm. Besides that, as a turn-on fluorescent probe, it shows high selectivity and sensitivity for Cys over other metal ions and amino acids including the similar structured homocysteine (Hcy) and glutathione (GSH)...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29759174/a-highly-selective-fluorescent-probe-for-cyanide-ion-and-its-detection-mechanism-from-theoretical-calculations
#11
Li Li, Minghui Zan, Xingwang Qie, Peng Miao, Juan Yue, Zhimin Chang, Zheng Wang, Fu-Quan Bai, Hong-Xing Zhang, James K Ferri, Wen-Fei Dong
A new cyanide probe has been prepared by one-step synthesis and evaluated by UV-vis and fluorescent method. This probe is combined by a fluorene part and a hemicyanine group through a conjugated linker, which is found to show rapid response, high selectivity and sensitivity for cyanide anions with significant dual colorimetric and fluorescent signal changes in aqueous solution. An intramolecular charge transfer (ICT) effect plays a key role in the CN- sensing properties, and the details of this mechanism are further supported by DFT and TD-DFT calculations...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29757643/peridinin-torsional-distortion-and-bond-length-alternation-introduce-intramolecular-charge-transfer-and-correlated-triplet-pair-intermediate-excited-states
#12
Elliot J Taffet, Gregory D Scholes
The nature of intramolecular charge transfer (ICT) and the mechanism of intramolecular singlet fission (SF) in peridinin remain open research questions. Obtaining an understanding of the population evolution from the bright state to dark states following a photoinduced electronic transition is critical. Unambiguously describing this evolution in peridinin, and light-harvesting carotenoids in general, has proven elusive experimentally and computationally. To offer a balanced description of bright- and dark-state electronic structure, we here apply ab initio multireference perturbation theory quantum chemistry-the density matrix renormalization group self-consistent-field (DMRG-SCF) and complete-active space self-consistent field (CASSCF) with second-order N-electron valence perturbation theory (NEVPT2)...
May 14, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29754119/a-pilot-study-and-brief-overview-of-rehabilitation-via-virtual-environment-in-patients-suffering-from-dementia
#13
Th Fasilis, P Patrikelis, A Siatouni, A Alexoudi, A Veretzioti, L Zachou, S-St Gatzonis
Dementia is one of the increasing problems of modern societies. The immediate cure is not a possible solution, at least at the moment, but science has found a number of new ways to retard and under specific conditions to halt its development. A potential, and constantly evolving scientific field is the use of Computerized Cognitive Rehabilitation (CCR) and Virtual Environments (Vr.E). According to the existing literature, subjecting patients to various neuro-rehabilitative conditions within 3D virtual environments, allows them to obtain significant therapeutic benefits in which both transferability and durations over time are observed, in relation to the training period of the intervention...
January 2018: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29754048/selective-and-sensitive-fluorescent-sensor-for-pd-2-using-coumarin-460-for-real-time-and-biological-applications
#14
Bosco Christin Maria Arputham Ashwin, Gandhi Sivaraman, Thambusamy Stalin, Rathinam Yuvakkumar, Paulpandian Muthu Mareeswaran
The efficient fluorescent property of coumarin 460 (C460) is utilized to sense the Pd2+ selectively and sensitively. Fabrication of a sensor strip using commercial adhesive tape is achieved and the detection of Pd2+ is attempted using a handy UV torch. The naked eye detection in solution state using UV chamber is also attempted. The calculated high binding constant values support the strong stable complex formation of Pd2+ with C460. The detection limit up to 2.5 × 10-7  M is achieved using fluorescence spectrometer, which is considerably low from the WHO's recommendation...
May 3, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29753353/cost-effectiveness-of-a-technology-facilitated-depression-care-management-adoption-model-in-safety-net-primary-care-patients-with-type-2-diabetes
#15
Joel W Hay, Pey-Jiuan Lee, Haomiao Jin, Jeffrey J Guterman, Sandra Gross-Schulman, Kathleen Ell, Shinyi Wu
BACKGROUND: The Diabetes-Depression Care-Management Adoption Trial is a translational study of safety-net primary care predominantly Hispanic/Latino patients with type 2 diabetes in collaboration with the Los Angeles County Department of Health Services. OBJECTIVES: To evaluate the cost-effectiveness of an information and communication technology (ICT)-facilitated depression care management program. METHODS: Cost-effectiveness of the ICT-facilitated care (TC) delivery model was evaluated relative to a usual care (UC) and a supported care (SC) model...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29752737/fluoride-anion-sensing-mechanism-of-a-bodipy-linked-hydrogen-bonding-probe
#16
Yang Li, Junsheng Chen, Tian-Shu Chu
The sensing mechanism of a fluoride-anion probe BODIPY-amidothiourea (1c) has been elucidated through the density functional theory (DFT) and time-dependent density functional theory (TDDFT) calculations. The theoretical study indicates that in the DMSO/water mixtures the fluorescent sensing has been regulated by the fluoride complex that formed between the probe 1c/two water molecules and the fluoride anion, and the excited-state intermolecular hydrogen bond (H-B) plays an important role in the fluoride sensing mechanism...
May 11, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29750798/guidelines-for-safe-handling-of-hazardous-drugs-a-systematic-review
#17
Mari A Bernabeu-Martínez, Mateo Ramos Merino, Juan M Santos Gago, Luis M Álvarez Sabucedo, Carmina Wanden-Berghe, Javier Sanz-Valero
OBJECTIVE: To review the scientific literature related to the safe handling of hazardous drugs (HDs). METHOD: Critical analysis of works retrieved from MEDLINE, the Cochrane Library, Scopus, CINHAL, Web of Science and LILACS using the terms "Hazardous Substances", "Antineoplastic Agents" and "Cytostatic Agents", applying "Humans" and "Guidelines" as filters. Date of search: January 2017. RESULTS: In total, 1100 references were retrieved, and from those, 61 documents were selected based on the inclusion and exclusion criteria: 24 (39...
2018: PloS One
https://www.readbyqxmd.com/read/29750241/exploring-privilege-in-the-digital-divide-implications-for-theory-policy-and-practice
#18
Mei Lan Fang, Sarah L Canham, Lupin Battersby, Judith Sixsmith, Mineko Wada, Andrew Sixsmith
Background and Objectives: The digital revolution has resulted in innovative solutions and technologies that can support the well-being, independence, and health of seniors. Yet, the notion of the "digital divide" presents significant inequities in terms of who accesses and benefits from the digital landscape. To better understand the social and structural inequities of the digital divide, a realist synthesis was conducted to inform theoretical understandings of information and communication technologies (ICTs); to understand the practicalities of access and use inequities; to uncover practices that facilitate digital literacy and participation; and to recommend policies to mitigate the digital divide...
May 10, 2018: Gerontologist
https://www.readbyqxmd.com/read/29749624/image-quality-of-conventional-images-of-dual-layer-spectral-ct-a-phantom-study
#19
F van Ommen, E Bennink, A Vlassenbroek, J W Dankbaar, A M R Schilham, M A Viergever, H W A M de Jong
PURPOSE: Spectral CT using a dual layer detector offers the possibility of retrospectively introducing spectral information to conventional CT images. In theory, the dual-layer technology should not come with a dose or image quality penalty for conventional images. In this study, we evaluate the influence of a dual-layer detector (IQon Spectral CT, Philips) on the image quality of conventional CT images, by comparing these images with those of a conventional but otherwise technically comparable single-layer CT scanner (Brilliance iCT, Philips), by means of phantom experiments...
May 10, 2018: Medical Physics
https://www.readbyqxmd.com/read/29748905/diabetes-care-in-the-digital-era-a-synoptic-overview
#20
REVIEW
Farhad Fatehi, Anish Menon, Dominique Bird
PURPOSE OF REVIEW: Diabetes care is undergoing a remarkable transformation by the advancements in information and communications technology (ICT). The aim of this review is to provide a general overview of various ICT-based interventions for diabetes care, challenges of their adoption, and consider future directions. RECENT FINDINGS: A number of systematic reviews have examined studies on various aspects of telemedicine and eHealth for diabetes care, but they are generally focused on one specific type of technology application for diabetes care...
May 10, 2018: Current Diabetes Reports
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