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https://www.readbyqxmd.com/read/29149650/iron-chelation-therapy-in-lower-ipss-risk-myelodysplastic-syndromes-which-subtypes-benefit
#1
Shannon A Wong, Heather A Leitch
BACKGROUND: Analyses suggest MDS patients with higher serum ferritin levels (SF) have inferior overall survival (OS), in one study across MDS subtypes. Multiple analyses suggest those with high SF receiving iron chelation therapy (ICT) have superior OS, but which MDS subtypes benefit from ICT remains undefined. METHODS: We performed survival analyses of MDS subtypes by receipt of ICT. RESULTS: 182 MDS were lower IPSS risk and received red blood cell (RBC) transfusions; 63 received ICT...
November 11, 2017: Leukemia Research
https://www.readbyqxmd.com/read/29149316/use-of-information-and-communication-technologies-in-the-formal-and-informal-health-system-responses-to-the-2015-nepal-earthquakes
#2
Olivia Crane, Julie Balen, Bhimsen Devkota, Sudha Ghimire, Simon Rushton
Information and Communication Technologies (ICTs) are increasingly recognized for their potential contributions to health service delivery in Low-and Middle-Income Countries (LMICs). As well as playing a role in improving the provision of health services under everyday 'normal' circumstances, ICTs can also be important in preparing for, mitigating, responding to and recovering from disasters. This research explores the use of ICTs in a natural disaster situation in Nepal, a country affected by a series of strong earthquakes in 2015...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29146614/heart-rate-reduction-improves-biventricular-function-and-interactions-in-experimental-pulmonary-hypertension
#3
Olga Gomez, Kenichi Okumura, Osami Honjo, Mei Sun, Ryo Ishii, Bart Bijens, Mark K Friedberg
OBJECTIVES: To investigate mechanisms of heart rate (HR) reduction on biventricular function and interactions in experimental pulmonary arterial hypertension (PAH). METHODS: We compared cardiac-cycle mechanics and interventricular interactions in 15 sham, 8 monocrotaline-PAH, 9 PAH+carvedilol and 8 PAH+ivabradine rats. We used echocardiography to assess biventricular function, timing of cardiac- cycle events and septal position in PAH rats; and related HR reduction effect on biventricular function measured by echocardiography and conductance catheter...
November 16, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29143241/a-highly-selective-naphthalimide-based-chemosensor-naked-eye-colorimetric-and-fluorescent-turn-on-recognition-of-al-3-and-its-application-in-practical-samples-test-paper-and-logic-gate
#4
Na-Na Li, Shuang Zeng, Ming-Qiang Li, Yu-Qing Ma, Xue-Jiao Sun, Zhi-Yong Xing, Jin-Long Li
A novel naphthalimide-based colorimetric and fluorescent turn-on chemosensor for Al(3+) was synthesized and characterized with spectroscopic techniques. In MeOH solution, BPAM showed high selectivity and sensitivity to Al(3+) by a 60-fold fluorescence enhancement and blue-shift absorption with visible color changes attributed to the contribution of chelation enhanced fluorescence (CHEF) and inhibition of intramolecular charge transfer (ICT). A 1:1 BPAM-Al(3+) complex confirmed by job's plot and HRMS with a binding constant of 6...
November 16, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/29142576/frequency-and-the-risk-factors-of-hepatitis-c-virus-in-pregnant-women-a-hospital-based-descriptive-study-in-gadap-town-karachi
#5
Kausar Jilani, Bushra Zulfiqar, Qadir Bux Memon, Muhammad Faisal Fahim
Objective: To determine the frequency and the risk factors of hepatitis C virus in pregnant women at Al-Tibri Medical College & Hospital in Gadap Town Karachi. Methods: This was a descriptive cross sectional study conducted at Obstetrics & Gynecology OPD of Al-Tibri Medical College & Hospital, Isra University Karachi Campus from 10(th) June to 10(th) September 2016. A total of 400 pregnant women of 16-45 years of age, who came in outpatient department for antenatal checkup were selected for the study...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29136878/highly-sensitive-and-selective-turn-on-fluorescent-chemosensors-for-hg-2-based-on-thioacetal-modified-pyrene
#6
Yunyan Gao, Tuotuo Ma, Zhize Ou, Wenjiao Cai, Guoqiang Yang, Yi Li, Moheng Xu, Qingqing Li
This work reports a facile strategy for the synthesis of water-soluble fluorescent probes Pyr1 and Pyr2, which have carboxyl and hydroxyl group in the side chain of thioacetal moiety, respectively. Pyr1-2 exhibit exclusively selective turn-on fluorescence response towards Hg(2+) over other cations, based on intramolecular charge transfer (ICT) mechanism. Upon addition of Hg(2+), the thioacetal moiety in Pyr1-2 can be converted to aldehyde group, which is confirmed by (1)H NMR titrations. The detection limits for Pyr1-2 are less than 1...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29130976/discontinued-information-and-communication-technology-usage-among-older-adults-in-continuing-care-retirement-communities-in-the-united-states
#7
R V Rikard, Ronald W Berkowsky, Shelia R Cotten
BACKGROUND: Older adults are increasingly using information and communication technologies (ICTs). Recent studies show beneficial effects of using ICTs for older adults, particularly in terms of reducing loneliness and depression. However, little is known about the factors that may prevent discontinued ICT use in populations that may be at greater risk, such as those in continuing care retirement communities (CCRCs). OBJECTIVES: The purpose of this study is to examine a range of factors that may influence discontinued (1) ICT use, (2) searching for health information, and (3) searching for general information over time among CCRC residents...
November 9, 2017: Gerontology
https://www.readbyqxmd.com/read/29128998/technology-use-and-its-association-with-health-and-depressive-symptoms-in-older-cancer-survivors
#8
Hee Yun Lee, Jeehoon Kim, Monica Sharratt
PURPOSE: Acknowledging the expanding influence of technology in the promotion of health and wellness, this study assessed the role of information and communication technology (ICT) use in the lives of older cancer survivors. METHODS: A community sample of cancer survivors aged 65 and older (N = 1411) was extracted from a 2011 U.S. National Health and Aging Trends Study dataset. Weighted multiple regression and multinomial logistic regression analyses were performed to explore the relationships between survey respondents' ICT use and their self-rated health status and depressive symptoms...
November 11, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29125632/median-sternotomy-versus-intercostal-thoracotomy-for-lung-lobectomy-a-comparison-of-short-term-outcome-in-134-dogs
#9
Seth Bleakley, Kevin Phipps, Brian Petrovsky, Eric Monnet
OBJECTIVE: To compare short-term outcomes between dogs undergoing lung lobectomy via median sternotomy (MS) or intercostal thoracotomy (ICT). STUDY DESIGN: Retrospective case control study. METHODS: Medical records of dogs that underwent lung lobectomy via MS or ICT at a single institution were reviewed for demographics, intraoperative findings, and postoperative management and outcomes. Dogs with pleural effusion, pneumonia, migrating foreign body, lung abscess, spontaneous pneumothorax, or lung lobe torsion were excluded...
November 10, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29118164/evaluation-of-in-house-and-commercial-serological-tests-for-diagnosis-of-human-tularemia
#10
Hadjila Yanes, Aurélie Hennebique, Isabelle Pelloux, Sandrine Boisset, Dominique J Bicout, Yvan Caspar, Max Maurin
Tularemia is a zoonosis caused by the bacterium Francisella tularensis Its specific diagnosis remains based on serological methods, while detection of F. tularensis in clinical samples by culture or PCR is rarely obtained. The aim of the present study was to evaluate the performance of the SERION ELISA classic Francisella tularensis IgG and IgM tests (Virion/Serion GmbH Institute, Würzburg, Germany) and the VIRapid® Tularemia immunochromatographic (ICT) test (VIRCELL, Granada, Spain), compared to the in-house microagglutination (MAT) and indirect immunofluorescence (IFA) tests currently used at the French National Reference Centre for Francisella...
November 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29117185/engaging-with-change-information-and-communication-technology-professionals-perspectives-on-change-in-the-context-of-the-brexit-vote
#11
Elizabeth Lomas, Julie McLeod
BACKGROUND: Information and Communication Technology (ICT) has been a key agent of change in the 21st century. Given the role of ICT in changing society this research sought to explore the responses and attitudes to change from ICT professionals and ICT academics in dealing with the potentially far reaching political challenge triggered by the UK's 2016 European Union Referendum and its decision to leave the European Union (referred to as Brexit). Whilst the vote was a UK based decision its ramifications have global implications and as such the research was not confined to the UK...
2017: PloS One
https://www.readbyqxmd.com/read/29111658/structure-property-correlation-in-luminescent-indolo-3-2-b-indole-idid-derivatives-unraveling-the-mechanism-of-high-efficiency-thermally-activated-delayed-fluorescence-tadf
#12
Chi Hyun Ryoo, Illhun Cho, Jongseok Han, Jung-Hoon Yang, Ji Eon Kwon, Sehun Kim, Hyein Jeong, Changhee Lee, Soo Young Park
A series of indolo[3,2-b]indole (IDID) derivatives are designed as a novel structural platform for thermally activated delayed fluorescence (TADF) emitters. Intramolecular charge transfer (ICT)-type molecules consisting of IDID donor (D) and various acceptor (A) moieties are synthesized and characterized in the protocol of the systematical structure-property correlation. IDID derivatives exhibit high efficiency, prompt fluorescence as well as TADF with emission ranges tuned by the chemical structure of the acceptor units...
November 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29110723/molecular-and-serological-detection-of-bovine-babesiosis-in-indonesia
#13
Azirwan Guswanto, Puttik Allamanda, Euis Siti Mariamah, Sodirun Sodirun, Putut Eko Wibowo, Liliek Indrayani, Rudi Harso Nugroho, I Ketut Wirata, Nur Jannah, Lepsi Putri Dias, Hadi Purnama Wirawan, Rochmadi Yanto, Bumduuren Tuvshintulga, Thillaiampalam Sivakumar, Naoaki Yokoyama, Ikuo Igarashi
BACKGROUND: Bovine babesiosis, mainly caused by Babesia bovis and B. bigemina, is a huge threat to the livestock industry. In Indonesia, the current distribution of the disease is unknown due to a lack of scientific study. METHODS: In the present study, 487 blood samples were collected from cattle with different breeding and age groups in a broad geographical area across the archipelago. The presence of antibodies and current infections of B. bovis and B. bigemina were determined using enzyme-linked immunosorbent assay (ELISA), immunochromatographic test (ICT), and nested PCR (nPCR) targeting B...
November 6, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29108929/development-of-a-new-ict-based-multisensor-blood-pressure-monitoring-system-for-use-in-hemodynamic-biomarker-initiated-anticipation-medicine-for-cardiovascular-disease-the-national-impact-program-project
#14
REVIEW
Kazuomi Kario, Naoko Tomitani, Hiroshi Kanegae, Nobuhiko Yasui, Masafumi Nishizawa, Takeshi Fujiwara, Takeya Shigezumi, Ryozo Nagai, Hiroshi Harada
We have developed a multisensor home and ambulatory blood pressure (BP) monitoring system for monitoring 24-hr central and brachial BP variability concurrent with physical activity (PA), temperature, and atmospheric pressure. The new BP monitoring system utilizes our recently developed biological and environmental signal monitoring Information Communication Technology/Internet of Things system, which can simultaneously monitor the environment (temperature, illumination, etc.) of different rooms in a house (entryway, bedroom, living room, bathing room, and toilet), and a wrist-type high-sensitivity actigraph for identifying the location of patients...
November 3, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29102449/a-survey-on-consumers-attitude-towards-storing-and-end-of-life-strategies-of-small-information-and-communication-technology-devices-in-spain
#15
María D Bovea, Valeria Ibáñez-Forés, Victoria Pérez-Belis, Pablo Juan
This study analyses the current habits and practices towards the store, repair and second-hand purchase of small electrical and electronic devices belonging to the category of information and communication technology (ICT). To this end, a survey was designed and conducted with a representative sample size of 400 individuals through telephone interviews for the following categories: MP3/MP4, video camera, photo camera, mobile phone, tablet, e-book, laptop, hard disk drive, navigator-GPS, radio/radio alarm clock...
November 1, 2017: Waste Management
https://www.readbyqxmd.com/read/29101863/contemporary-use-of-intraoperative-imaging-in-glioma-surgery-a-survey-among-eans-members
#16
Jan Coburger, Arya Nabavi, Ralph König, Christian Rainer Wirtz, Andrej Pala
OBJECTIVES: In glioma surgery, intraoperative imaging is regarded highly valuable to improve extent of resection. Current distribution of intraoperative imaging techniques is largely unknown. Further, controversy exists which method might be most beneficial. PATIENTS AND METHODS: We performed a web-based survey among members of the European Association of Neurological Surgeons(EANS) from April to May 2017. Our questionnaire included intraoperative MRI(iMRI), 5-aminolevulinic acid(5-ALA), intraoperative ultrasound(iUS),Na-Fluorescein and intraoperative CT(iCT)...
December 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29099088/a-ratiometric-fluorescent-sensor-for-cd-2-based-on-internal-charge-transfer
#17
Dandan Cheng, Xingliang Liu, Yadian Xie, Haitang Lv, Zhaoqian Wang, Hongzhi Yang, Aixia Han, Xiaomei Yang, Ling Zang
This work reports on a novel fluorescent sensor 1 for Cd(2+) ion based on the fluorophore of tetramethyl substituted bis(difluoroboron)-1,2-bis[(1H-pyrrol-2-yl)methylene]hydrazine (Me₄BOPHY), which is modified with an electron donor moiety of N,N-bis(pyridin-2-ylmethyl)benzenamine. Sensor 1 has absorption and emission in visible region, at 550 nm and 675 nm, respectively. The long wavelength spectral response makes it easier to fabricate the fluorescence detector. The sensor mechanism is based on the tunable internal charge transfer (ICT) transition of molecule 1...
November 2, 2017: Sensors
https://www.readbyqxmd.com/read/29090913/selective-modulation-of-ict-and-pet-processes-in-n-aryl-1-8-naphthalimide-derivatives-applications-in-reaction-based-fluorogenic-sensing-of-sulfide
#18
Ranjith Kumar Meka, Michael David Heagy
Three reaction-based fluorescent probes based on two new naphthalimide platforms were developed for the detection of H2S. A new approach in detecting H2S by the reduction of an azide to a triazene intermediate in aqueous media is reported. Given their design features, these chemodosimeters provide useful insights into the relatively unexplored area of C0 spacers between receptor:reporter components. The N-aryl-1,8-naphthalimide platform features straightforward placement of the ICT and PET modulators on the same molecule...
November 1, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29090578/ultrafast-excited-state-dynamics-of-all-trans-capsanthin-in-organic-solvents
#19
Mirko Scholz, Oliver Flender, Thomas Lenzer, Kawon Oum
The C40 carotenoid capsanthin is of photophysical interest because it belongs to the family of terminally carbonyl-substituted apocarotenes. These have the potential to exhibit intramolecular charge transfer (ICT) character in the excited state. We studied its ultrafast dynamics in different solvents using broadband transient absorption spectroscopy in the 260-1600 nm range. Photoexcitation initially populated the S2(1(1)Bu(+)) state which decayed to the S1(2(1)Ag(-)) state in 120-150 fs. The lifetime of the S1 state decreased from 10...
November 1, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29083850/aiee-active-donor-acceptor-donor-based-hexaphenylbenzene-probe-for-recognition-of-aliphatic-and-aromatic-amines
#20
Subhamay Pramanik, Harnimarta Deol, Vandana Bhalla, Manoj Kumar
In the present investigation, an intramolecular charge transfer (ICT) and aggregation induced emission enhancement (AIEE) active donor-acceptor-donor (D-A-D) system 5 having fumaronitrile as the acceptor and hexaphenylbenzene (HPB) as the donor moieties joined through rotatable phenyl rings has been designed and synthesized that is highly emissive in the solid state and exhibits stimuli-responsive reversible piezochromic behavior upon grinding and heating. Because of its AIEE characteristics, HPB derivative 5 undergoes aggregation to form fluorescent aggregates in mixed aqueous media that exhibit ratiometric fluorescence response toward aliphatic amines (primary/secondary/tertiary) and turn-off response toward aromatic amines and hence differentiates between them...
October 30, 2017: ACS Applied Materials & Interfaces
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