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https://www.readbyqxmd.com/read/28918132/assessing-precision-bias-and-sigma-metrics-of-53-measurands-of-the-alinity-ci-system
#1
Sten Westgard, Victoria Petrides, Sharon Schneider, Marvin Berman, Jörg Herzogenrath, Anthony Orzechowski
Assay performance is dependent on the accuracy and precision of a given method. These attributes can be combined into an analytical Sigma-metric, providing a simple value for laboratorians to use in evaluating a test method's capability to meet its analytical quality requirements. Sigma-metrics were determined for 37 clinical chemistry assays, 13 immunoassays, and 3 ICT methods on the Alinity ci system. METHODS: Analytical Performance Specifications were defined for the assays, following a rationale of using CLIA goals first, then Ricos Desirable goals when CLIA did not regular the method, and then other sources if the Ricos Desirable goal was unrealistic...
September 13, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28917746/a-highly-selective-and-ratiometric-fluorescent-probe-for-cyanide-by-rationally-altering-the-susceptible-h-atom
#2
Yuanqiang Hao, Khac Hong Nguyen, Yintang Zhang, Guan Zhang, Shengnan Fan, Fen Li, Chao Guo, Yuanyuan Lu, Xiaoqing Song, Peng Qu, You-Nian Liu, Maotian Xu
A highly selective and ratiometric fluorescent probe for cyanide was rationally designed and synthesized. The probe comprises a fluorophore unit of naphthalimide and a CN(-) acceptor of methylated trifluoroacetamide group. For these previous reported trifluoroacetamide derivative-based cyanide chemosensors, the H-atom of amide adjacent to trifluoroacetyl group is susceptible to be attacked by various anions (CN(-) itself, F(-), AcO(-), et al.) and even the solvent molecule, which resulted in the bewildered reaction mechanism and poor selectivity of the assay...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917303/the-evaluation-of-gm6-based-elisa-and-ict-as-diagnostic-methods-on-a-mongolian-farm-with-an-outbreak-of-non-tsetse-transmitted-horse-trypanosomosis
#3
Batdorj Davaasuren, Tovuu Amgalanbaatar, Simon Peter Musinguzi, Keisuke Suganuma, Davaajav Otgonsuren, Ehab Mossaad, Sandagdorj Narantsatsral, Banzragch Battur, Badgar Battsetseg, Xuenan Xuan, Noboru Inoue
Trypanosoma equiperdum, which is the etiological agent of dourine, spreads through sexual intercourse in equines. Dourine (T. equiperdum) has been reported in Mongolia, where it is considered an economically important disease of horses. T. evansi has also been reported in Mongolian domestic animals. The objective of this study was to evaluate the potential application of recombinant T. evansi GM6 (rTeGM6-4r)-based diagnostic methods on a farm with an outbreak of non-tsetse transmitted horse trypanosomosis. Ninety-seven percent homology was found between the amino acid sequences of T...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28915010/molecular-engineering-for-enhanced-charge-transfer-in-thin-film-photoanode
#4
Jeong Soo Kim, Byung-Man Kim, Un-Young Kim, HyeonOh Shin, Jung Seung Nam, Deok-Ho Roh, Tae-Hyuk Kwon
We developed three types of dithieno[3,2-b;2',3'-d]thiophene (DTT)-based organic sensitizers for high-performance thin photoactive TiO2 films and investigate the simple but powerful molecular engineering of different types of bonding between the triarylamine electron donor and the conjugated DTT π-bridge by the introduction of single, double, and triple bonds. As a result, with only 1.3-μm transparent and 2.5-μm TiO2 scattering layers, the triple bond sensitizer (T-DAHTDTT) shows the highest power conversion efficiency (η = 8...
September 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28912193/effectiveness-of-a-multifactorial-intervention-based-on-an-application-for-smartphones-heart-healthy-walks-and-a-nutritional-workshop-in-patients-with-type-2-diabetes-mellitus-in-primary-care-emid-study-protocol-for-a-randomised-controlled-trial
#5
Rosario Alonso-Domínguez, Manuel A Gómez-Marcos, Maria C Patino-Alonso, Natalia Sánchez-Aguadero, Cristina Agudo-Conde, Carmen Castaño-Sánchez, Luis García-Ortiz, José I Recio-Rodríguez
INTRODUCTION: New information and communication technologies (ICTs) may promote lifestyle changes, but no adequate evidence is available on their combined effect of ICTs with multifactorial interventions aimed at improving diet and increasing physical activity in patients with type 2 diabetes mellitus (DM2). The primary objective of this study is to assess the effect of a multifactorial intervention to increase physical activity and adherence to Mediterranean diet in DM2. METHODS AND ANALYSIS: Study scope and population: The study will be conducted at 'La Alamedilla' primary care research unit in Salamanca (Spain)...
September 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28901370/a-fluorescent-ph-probe-for-acidic-organelles-in-living-cells
#6
Jyun-Wei Chen, Chih-Ming Chen, Cheng-Chung Chang
A water-soluble pH sensor, 2-(6-(4-aminostyryl)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N, N-dimethylethanamine (ADA), was synthesized based on the molecular design of photoinduced electron transfer (PET) and intramolecular charge transfer (ICT). The fluorescence emission response against a pH value is in the range 3-6, which is suitable for labelling intracellular pH-dependent microenvironments. After biological evolution, ADA is more than a pH biosensor because it is also an endocytosis pathway tracking biosensor that labels endosomes, late endosomes, and lysosome pH gradients...
September 13, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28899442/applications-of-256-slice-spiral-computed-tomography-perfusion-scanning-in-limb-salvage-after-high-voltage-electrical-injury
#7
Pengcheng Ma, Yong Sun, Xintang Zhang, Hui Liu, Canli Liu, Jing Zhao
OBJECTIVE: This study aimed to investigate the applications of intelligent 256-slice computed tomography (iCT) perfusion imaging in high-voltage electrical injuries (HVEIs). METHODS: 256-slice iCT was used to perform perfusion scanning for 48 patients with HVEI to detect the perfusion parameters. RESULTS: The blood flow (BF) and peak enhancement intensity (PEI) values of the plane lower than the amputation level of the diseased side (ALD) were smaller than those of the corresponding healthy side (P<0...
September 13, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28898308/-the-treatment-of-cannabis-dependence-clinical-work-psychotherapy-and-evidence
#8
José Capece, Federico Pavlovsky
Identifying compulsive consumption of marijuana in association with another mental disorder (attentional defcit disorder, bipolar disorder, depression or psychosis) presents the challenge of clarifying validated therapeutic strategies, especially within the teen population, in which it shows the highest prevalence. The ever-increasing prevalence and the need for regional treatments, demand that we approach this health matter as a public health issue. The ideological con?icts related to the necessary decriminalization of consumption and the current debate on the medical use of marijuana often confuse the urgent need to establish effective therapeutic strategies for the population affected by this mental disorder...
November 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28892473/a-multi-center-field-study-of-two-point-of-care-tests-for-circulating-wuchereria-bancrofti-antigenemia-in-africa
#9
Cédric B Chesnais, Naomi-Pitchouna Awaca-Uvon, Fatoma K Bolay, Michel Boussinesq, Peter U Fischer, Lincoln Gankpala, Aboulaye Meite, François Missamou, Sébastien D Pion, Gary J Weil
BACKGROUND: The Global Programme to Eliminate Lymphatic Filariasis uses point-of-care tests for circulating filarial antigenemia (CFA) to map endemic areas and for monitoring and evaluating the success of mass drug administration (MDA) programs. We compared the performance of the reference BinaxNOW Filariasis card test (ICT, introduced in 1997) with the Alere Filariasis Test Strip (FTS, introduced in 2013) in 5 endemic study sites in Africa. METHODOLOGY: The tests were compared prior to MDA in two study sites (Congo and Côte d'Ivoire) and in three sites that had received MDA (DRC and 2 sites in Liberia)...
September 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28891597/12-month-longitudinal-parasitological-assessment-of-lymphatic-filariasis-positive-individuals-impact-of-bi-annual-treatment-with-ivermectin-and-albendazole
#10
John N Kanamitie, Collins S Ahorlu, Joseph Otchere, Fred Aboagye-Antwi, Bethel Kwansa-Bentum, Daniel A Boakye, Nana-Kwadwo Biritwum, Michael D Wilson, Dziedzom K de Souza
OBJECTIVE: Mass drug Administration (MDA) for the control of Lymphatic filariasis (LF), in Ghana, started in the year 2000. While this had great success in many implementation units, there remain areas with persistent transmission, after more than 10 years of treatment. A closer examination of the parasite populations could help understand the reasons for persistent infections, and formulatingn appropriate strategies to control LF in these areas of persistent transmission. MATERIALS AND METHODS: In a longitudinal study, we assessed the prevalence of microfilaraemia (mf) in two communities with 12 years of MDA in Ghana...
September 11, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28891254/fetal-isovolumetric-time-intervals-as-a-marker-of-abnormal-cardiac-function-in-fetal-anemia-from-homozygous-alpha-thalassemia-1-disease
#11
Fuanglada Tongprasert, Kasemsri Srisupundit, Suchaya Luewan, Kuntharee Traisrisilp, Phudit Jatavan, Theera Tongsong
OBJECTIVE: To determine whether fetal isovolumetric time intervals can be an early sonographic marker of fetal anemia in fetuses with homozygous alpha thalassemia-1. METHODS: Pregnancies at risk for fetal homozygous alpha thalassemia-1 disease at 18-22 weeks were recruited before cordocentesis for hemoglobin typing. Isovolumetric contraction time (ICT) and isovolumetric relaxation time (IRT) intervals were measured by placing pulsed wave Doppler sample volume within the left ventricle to obtain the mitral and aortic waveform...
August 11, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28890823/does-lymphocyte-to-monocyte-ratio-before-during-or-after-definitive-chemoradiation-for-locally-advanced-pancreatic-cancer-predict-for-clinical-outcomes
#12
Irene Giacomelli, Daniele Scartoni, Homan Mohammadi, William F Regine, Michael D Chuong
BACKGROUND: Elevated pre-treatment lymphocyte (L) to monocyte (M) ratio (LMR) in peripheral blood has been suggested to correlate with improved survival in some malignancies, but data in the context of pancreatic cancer (PC) is limited. The aim of this study was to evaluate the prognostic significance of LMR before, during and after definitive chemoradiotherapy (CRT) for locally advanced pancreatic cancer (LAPC). METHODS: We retrospectively reviewed 57 patients with LAPC treated with definitive CRT at a single institution from 2005 to 2013...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28889737/selective-and-rapid-detection-of-nitric-oxide-by-a-two-photon-fluorescent-probe-in-live-cells-and-tissue-slices
#13
Chun-Guang Dai, Ji-Long Wang, Ying-Long Fu, Hongping Zhou, Qin-Hua Song
Nitric oxide (NO) is important signaling molecule implicated in numerous physiological and pathological processes. Although numerous NO fluorescent probes have been successfully developed in the past decade, it still remains limitations such as slow response, low selectivity, and short excitation wavelength (< 600 nm). In this Article, a two-photon fluorescent probe, NO-QA5, has been developed with 3-dimethylaminophenyl linking at 6-position of 5-aminoquinoline as both the active site and pre-fluorophore for detection of NO...
September 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28884181/probing-the-solvation-structure-and-dynamics-in-ionic-liquids-by-time-resolved-infrared-spectroscopy-of-4-dimethylamino-benzonitrile
#14
Rômulo A Ando, Samantha E Brown-Xu, Lisa N Q Nguyen, Terry L Gustafson
In this work we demonstrate the use of the push-pull model system 4-(dimethylamino)benzonitrile (DMABN) as a convenient molecular probe to investigate the local solvation structure and dynamics by means of time-resolved infrared spectroscopy (TRIR). The photochemical features associated with this system provide several advantages due to the high charge separation between the ground and charge transfer states involving the characteristic nitrile bond, and an excited state lifetime that is long enough to observe the slow solvation dynamics in organic solvents and ionic liquids...
September 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28880227/providing-personalized-energy-management-and-awareness-services-for-energy-efficiency-in-smart-buildings
#15
Eleni Fotopoulou, Anastasios Zafeiropoulos, Fernando Terroso-Sáenz, Umutcan Şimşek, Aurora González-Vidal, George Tsiolis, Panagiotis Gouvas, Paris Liapis, Anna Fensel, Antonio Skarmeta
Considering that the largest part of end-use energy consumption worldwide is associated with the buildings sector, there is an inherent need for the conceptualization, specification, implementation, and instantiation of novel solutions in smart buildings, able to achieve significant reductions in energy consumption through the adoption of energy efficient techniques and the active engagement of the occupants. Towards the design of such solutions, the identification of the main energy consuming factors, trends, and patterns, along with the appropriate modeling and understanding of the occupants' behavior and the potential for the adoption of environmentally-friendly lifestyle changes have to be realized...
September 7, 2017: Sensors
https://www.readbyqxmd.com/read/28879506/proton-induced-modulation-of-ict-and-pet-processes-in-an-imidazo-phenanthroline-based-bodipy-fluorophores
#16
Shrikant S Thakare, Goutam Chakraborty, Shantaram Kothavale, Soumyaditya Mula, Alok K Ray, Nagaiyan Sekar
BODIPY fluorophores linked with an imidazo-phenanthroline donor at α and β positions have been synthesized. Intriguing intramolecular charge transfer phenomenon is observed in both the dyes which has been extensively investigated using UV-vis absorption, steady-state and time-resolved fluorescence measurements. H-bonding and intrinsic polarity of the solvents has modulated the absorption and emission bands of these fluorophores strongly causing significant increase in the Stokes shifts. In spite of having difference only in terms of the position of donor subunit, the photophysics of these dyes are not only significantly different from each other, but contradictory too...
September 6, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28878967/resisting-the-urge-to-smoke-inhibitory-control-training-in-cigarette-smokers
#17
Sally Adams, Claire Mokrysz, Angela S Attwood, Marcus R Munafò
Impaired response inhibition is an important factor in tobacco dependence. We examined the effects of inhibitory control training (ICT) on inhibition, smoking resistance and cigarette use. Smokers (n = 55) abstained from smoking for 12 h prior to testing. On the test day, participants recorded cigarette use and completed pre-training measures of global and cue-specific (smoking-related) response inhibition. Participants were randomized to either an active or a control ICT group. The active group was required to repeatedly inhibit a response towards smoking cues (100%), while the control group was required to inhibit a response towards smoking and neutral cues with equal frequency (50%)...
August 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28876889/meta-alkoxy-substituted-difluoroboron-dibenzoylmethane-complexes-as-environment-sensitive-materials
#18
Margaret L Daly, Caroline Kerr, Christopher A DeRosa, Cassandra L Fraser
The optical properties of meta-alkoxy-substituted difluoroboron dibenzoylmethane dyes were investigated in solution and in the solid state. Meta-alkoxy substitution induced strong intramolecular charge transfer (ICT) from the oxygen-donating substituent to the halide and boron acceptors in the excited state, as compared to the π-π* transition that is observed with para-alkoxy substitution. The optical properties of para- and meta-substituted alkoxy boron dyes were evaluated by calculations, in dilute solution, and in solid-state films...
September 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28875054/current-status-of-electronic-medical-record-systems-in-hospitals-and-clinics-in-korea
#19
Young-Taek Park, Dongwoon Han
OBJECTIVES: Many healthcare organizations and professionals have had interests in healthcare information and communication technology (ICT). The objective of this study was to investigate the current status of overall healthcare ICT, especially focusing on Electronic Medical Record (EMR) systems in Korea. METHODS: This study used a part of the nationwide survey collected for the OECD benchmarking ICT study. The Health Insurance Review and Assessment Service conducted the survey from November 19, 2013 to January 10, 2014...
July 2017: Healthcare Informatics Research
https://www.readbyqxmd.com/read/28873916/ict-and-ud-preliminary-study-for-recommendations-to-design-accessible-university-courses
#20
Silvio Marcello Pagliara, Marta Sánchez Utgé, Lucia De Anna
Starting from the Universal Design in the educational context principles, the experiences gained during the FIRB project "Net@ccessibility" and the high-education courses for teachers' specialization on special education, this research will focus on preliminary studies in order to define the recommendations for designing accessible university courses.
2017: Studies in Health Technology and Informatics
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