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Naren P Tallapragada
In August 2015, Turing Pharmaceuticals acquired the marketing rights to Daraprim (pyrimethamine), a drug used to treat parasitic infections like malaria and toxoplasmosis. Soon after, Turing caused an uproar when it announced that it would raise the price per tablet of Daraprim from [Formula: see text], a 5500% price hike for a drug that has been on the market for over 60 years and off patent since the 1970s. Old, off-patent drugs are becoming increasingly expensive; Daraprim is the archetypal example. Turing had the power to set a high price for Daraprim because the drug's limited patient population, the absence of competing manufacturers, and a lack of therapeutic alternatives all created an effective monopoly...
April 2016: Journal of Law and the Biosciences
Clare A Johnson, Diana S Goodwine, Ingrid Passier
We present a case of a 57-year-old man who fell while climbing a mountain in California and sustained severe facial trauma. Three firefighters and 2 emergency physicians witnessed the fall and resuscitated the patient. The patient ultimately required a surgical cricothyrotomy performed with a pocket knife and Platypus hydration pack. The physicians made a makeshift positive pressure airway device using the Platypus hydration pack. We believe this is the first case report describing an improvised cricothyrotomy performed in the wilderness using only hiking gear...
October 18, 2016: Wilderness & Environmental Medicine
G D Stentiford, A Ramilo, E Abollo, R Kerr, K S Bateman, S W Feist, D Bass, A Villalba
The Paramyxida, closely related to haplosporidians, paradinids, and mikrocytids, is an obscure order of parasitic protists within the class Ascetosporea. All characterized ascetosporeans are parasites of invertebrate hosts, including molluscs, crustaceans and polychaetes. Representatives of the genus Marteilia are the best studied paramyxids, largely due to their impact on cultured oyster stocks, and their listing in international legislative frameworks. Although several examples of microsporidian hyperparasitism of paramyxids have been reported, phylogenetic data for these taxa are lacking...
October 17, 2016: Parasitology
Jing-Fen Wu, Huang-Lung Tsai, Ignasius Joanito, Yi-Chen Wu, Chin-Wen Chang, Yi-Hang Li, Ying Wang, Jong Chan Hong, Jhih-Wei Chu, Chao-Ping Hsu, Shu-Hsing Wu
A double-negative feedback loop formed by the morning genes CIRCADIAN CLOCK ASSOCIATED1 (CCA1)/LATE ELONGATED HYPOCOTYL (LHY) and the evening gene TIMING OF CAB EXPRESSION1 (TOC1) contributes to regulation of the circadian clock in Arabidopsis. A 24-h circadian cycle starts with the peak expression of CCA1 at dawn. Although CCA1 is targeted by multiple transcriptional repressors, including PSEUDO-RESPONSE REGULATOR9 (PRR9), PRR7, PRR5 and CCA1 HIKING EXPEDITION (CHE), activators of CCA1 remain elusive. Here we use mathematical modelling to infer a co-activator role for LIGHT-REGULATED WD1 (LWD1) in CCA1 expression...
October 13, 2016: Nature Communications
Anupama Sukhlecha
Incentives, pay hikes and timely promotions enhance the job performance of an employee. In medical institutes, too, satisfied teachers would train students in a better way leading to better equipped doctors and ultimately, greater patient satisfaction. A study in Malaysia links high levels of satisfaction of employees with good salary, promotions, and incentives.
October 2016: Indian Journal of Medical Ethics
Shelley D Golden, Matthew C Farrelly, Douglas A Luke, Kurt M Ribisl
BACKGROUND: About half of all US states have cigarette minimum price laws (MPLs) that require a per cent mark-up on prices, but research suggests they may not be very effective in raising prices. An alternative type of MPL sets a floor price below which packs cannot be sold, and may be more promising. This new type of MPL policy has only been implemented in 1 city, therefore its benefits relative to excise taxes is difficult to assess. METHODS: We constructed a set of possible state floor price MPL options, and matched them to possible state excise tax hikes designed to produce similar average price increases...
October 2016: Tobacco Control
Rita Rubin
No abstract text is available yet for this article.
September 24, 2016: Lancet
S M Saiful Islam, Amir Fattah Abru, Saeed Al Obaidani, Saud Al Shabibi, Sami Al Farsi
OBJECTIVES: To study and to establish the overall trends of computed tomography (CT) use and associated outcomes in the pediatric emergency department (PED) at Royal Hospital, Oman, from 2010 to 2014. METHODS: The hospital electronic medical record was retrospectively searched to find children (from birth to 12 years old) who had visited the PED and the number of CT requests between 1 January 2010 and 31 December 2014. The types of CT examinations ordered were analyzed according to anatomical location and were as follows; head, abdomen/pelvis, chest, cervical spine/neck, and others...
September 2016: Oman Medical Journal
Renee J Smith, James S Paterson, Elise Launer, Shanan S Tobe, Eliesa Morello, Remko Leijs, Shashikanth Marri, James G Mitchell
More than 97% of the world's freshwater reserves are found in aquifers, making groundwater one of the most important resources on the planet. Prokaryotic communities in groundwater underpin the turnover of energy and matter while also maintaining groundwater purity. Thus, knowledge of microbial transport in the subsurface is crucial for maintaining groundwater health. Here, we describe for the first time the importance of stygofauna as vectors for prokaryotes. The "hitch-hiking" prokaryotes associated with stygofauna may be up to 5 orders of magnitude higher in abundance and transported up to 34× faster than bulk groundwater flow...
2016: Scientific Reports
Olivier Espitia, Brigitte Dréno, Elisabeth Cassagnau, Quentin Didier, Thibaut Quillard, Christelle Nicol, Yann Le Bouch, Bernard Planchon, Marc-Antoine Pistorius
Although exercise-induced vasculitis (EIV) is usually misdiagnosed, it is not uncommon. Occurring mostly after prolonged exercise, especially in hot weather, EIV is an isolated cutaneous vasculitis with stereotypical presentation. This article reviews the clinical characteristics, treatments, and outcomes of EIV based on the published literature. We report 99 patients who developed EIV after walking, dancing, swimming, or hiking especially during hot weather, including the records of 16 patients with EIV treated at our hospital from 2007 to 2015...
September 3, 2016: American Journal of Clinical Dermatology
Caroline Hepperger, Peter Gföller, Christian Hoser, Hanno Ulmer, Felix Fischer, Wolfgang Schobersberger, Christian Fink
PURPOSE AND HYPOTHESIS: Improvements in pain, function and sports activity are the main goals of patients following total knee arthroplasty (TKA). Participation in sports has become an increasingly important contributor to patients' quality of life (QoL). Hiking is one of the most popular summer activities among elderly people in alpine regions. Consequently, this randomized controlled trial investigates the impact of a 3-month guided hiking programme on patients' functional abilities and QoL following TKA...
September 1, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
W de Kanter
In the Netherlands, every day some 100 adolescents become addicted to cigarettes. These new smokers fill the gap left by the 25% of smokers who die before reaching retirement age. The State Secretary for Health, Welfare and Sport in the Netherlands, the Royal Dutch Medical Association (KNMG), and the Dutch Cancer Society, Lung Foundation and Heart Foundation all support the concept of a tobacco-free generation. The concept is that, by applying public health interventions and restriction of tobacco accessibility through price hikes, in the near future none of the children in the Netherlands born in 2017 and beyond will take up smoking...
2016: Nederlands Tijdschrift Voor Geneeskunde
Michael McCarthy
No abstract text is available yet for this article.
2016: BMJ: British Medical Journal
Mohammad Furkan, Naveed Ahmad Fazili, Mohammad Afsar, Aabgeena Naeem
The propensity of native state to form aggregated and fibrillar assemblies is a hallmark of amyloidosis. Our study was focused at analyzing the aggregation and fibrillation tendency of cytochrome c in presence of an organic solvent i.e. acetonitrile. In vitro analysis revealed that the interaction of cytochrome c with acetonitrile facilitated the oligomerization of cytochrome c via the passage through an intermediate state which was obtained at 20 % v/v concentration of acetonitrile featured by a sharp hike in the ANS fluorescence intensity with a blue shift of 20 nm compared to the native state...
August 22, 2016: Journal of Fluorescence
Antonios A Augustinos, Arun Rajamohan, Georgios A Kyritsis, Antigone Zacharopoulou, Ihsan Ul Haq, Asya Targovska, Carlos Caceres, Kostas Bourtzis, Adly M M Abd-Alla
The Mediterranean fruit fly, Ceratitis capitata, is one of the most serious pests of fruit crops world-wide. During the last decades, area-wide pest management (AW-IPM) approaches with a sterile insect technique (SIT) component have been used to control populations of this pest in an effective and environment-friendly manner. The development of genetic sexing strains (GSS), such as the Vienna 8 strain, has been played a major role in increasing the efficacy and reducing the cost of SIT programs. However, mass rearing, extensive inbreeding, possible bottleneck phenomena and hitch-hiking effects might pose major risks for deterioration and loss of important genetic characteristics of domesticated insect...
2016: PloS One
(no author information available yet)
No abstract text is available yet for this article.
August 9, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Erin Dean
The RCN has called for more affordable accommodation for nurses as key workers in London faced a 20% rent hike.
August 3, 2016: Nursing Standard
(no author information available yet)
We report this week that a group of nurses living in a block of flats in south east London faced with a 20% rent hike have been given just 8 weeks to pay up or move out.
August 3, 2016: Nursing Standard
Scott N Drum, Oliver Faude, Emilie de Fay du Lavallaz, Remo Allemann, Gilles Nève, Lars Donath
BACKGROUND: Hiking at moderate altitude is a popular outdoor activity in seniors. Acute exercise or altitude can diminish balance performance. Thus, the present study examined the combined effects of altitude and walking on static and dynamic balance. METHODS: Thirty-six healthy seniors (age: 62 (SD: 4) y; BMI: 25 (5) kg/m(2)) were examined on three days. Firstly, walking velocity was determined at 85% of the first ventilatory threshold (VT1). Therefore, a ramp walking test on a treadmill was completed...
November 2016: Archives of Gerontology and Geriatrics
Adam D Hill
When performing detailed tasks related to climbing or hiking, accurate vision is important for safety. Acetazolamide is a medication commonly used to prevent acute mountain sickness, but it has an uncommon side effect of transient myopia. Reports of this side effect are mainly associated with its use in obstetrics, where it is often prescribed in higher doses than used in acute mountain sickness prophylaxis. We describe the case of a climber taking low-dose acetazolamide who developed transient myopia. We further describe potential mechanisms of this rare side effect as well as a novel approach of field management utilizing possible materials at hand...
September 2016: Wilderness & Environmental Medicine
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