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Stephen Barlas
Is industry consolidation a response to President Donald Trump's repeated denunciation of high drug prices and congressional hearings on the issue? The author considers whether any of this corporate collaboration will get at some of the significant, underlying problems in the drug-pricing space.
January 2018: P & T: a Peer-reviewed Journal for Formulary Management
Zhanju Yang, Qiao Wang, Ke Ma, Ping Shi, Wenbin Liu, Zhiwei Huang
OBJECTIVES: The study aims to explore the synergistically antifungal mechanism of fluconazole and berberine. METHODS: Biochemical and genetic analysis was performed to investigate the probable antifungal role of the combined use of berberine and fluconazole in Saccharomyces cerevisiae, a typical fungal cell model. RESULTS: Fluconazole led to an elevated cell membrane permeability in the wild type yeast BY4741, similar as the sterol synthesis deficient strains erg2Δ and erg6Δ...
December 26, 2017: Journal of Global Antimicrobial Resistance
Paweł Ćwiąkała, Rafał Kocierz, Edyta Puniach, Michał Nędzka, Karolina Mamczarz, Witold Niewiem, Paweł Wiącek
The research described in this paper deals with the documentation of hiking trails in alpine areas. The study presents a novel research topic, applying up-to-date survey techniques and top quality equipment with practical applications in nature conservation. The research presents the initial part of the process-capturing imagery, photogrammetric processing, quality checking, and a discussion on possibilities of the further data analysis. The research described in this article was conducted in the Tatra National Park (TNP) in Poland, which is considered as one of the most-visited national parks in Europe...
December 29, 2017: Sensors
Christoph Kolling, Mirela Borovac, Laurent Audigé, Andreas M Mueller, Hans-Kaspar Schwyzer
PURPOSE: This patient survey evaluated the return to previous sports activities in Swiss patients up to five years after reverse shoulder arthroplasty (RSA). METHODS: We screened our local shoulder arthroplasty registry for patients registered with a unilateral RSA due to rotator cuff deficiency between May 2010 and May 2015. Revision cases and patients already known as unwilling or unable to complete a German language questionnaire were excluded. Eligible patients received a paper questionnaire asking about their past and current sports activities, return time point and level of activity...
December 22, 2017: International Orthopaedics
Martin Faulhaber, Elena Pocecco, Martin Niedermeier, Gerhard Ruedl, Dagmar Walter, Regina Sterr, Hans Ebner, Wolfgang Schobersberger, Martin Burtscher
Objective: To analyse the circumstances of fatal and non-fatal mountain hiking accidents caused by falls. Methods: The study was designed as a retrospective analysis. Mountain hiking accidents caused by falls were documented during a 9-year period (2006-2014). After screening of all data for potential exclusion criteria the final sample size of 5368 accidents and 5665 victims was included into the analyses. Main outcome measures were details about accidents, victims, type of trail and surface...
2017: BMJ Open Sport & Exercise Medicine
Anna Schuh-Renner, Michelle Canham-Chervak, Darren W Hearn, P Ann Loveless, Bruce H Jones
The purpose of this study was to investigate injury incidence and factors associated with injury among employees at a large U.S. Army hospital to inform injury prevention planning and health promotion education efforts. Demographics, health behaviors, and injury history were collected by survey from hospital employees between October and December 2014. Descriptive statistics were reported and factors associated with injury were determined using multiple logistic regression. Respondents (380; 56% females, 44% males; 54% active duty military, 45% civilians) reported a prevalence of unhealthy behaviors (e...
December 1, 2017: Workplace Health & Safety
Helen Shen
No abstract text is available yet for this article.
December 14, 2017: Nature
Puligundla Krishna Chaitanya, Karnam Ashok Kumar, Bala Stalin, Gundeti Sadashivudu, Maddali Lakshmi Srinivas
Introduction: BCR-ABL1 kinase domain mutations represent the most frequent mechanism of resistance to tyrosine kinase inhibitor (TKI) therapy, being detected in 40%-50% of imatinib-resistant patients with chronic myeloid leukemia in chronic phase (CML-CP). Over 100 BCR-ABL1 single-point mutations have been reported in patients with imatinib-resistant CML. There were few studies reported from India on BCR-ABL kinase mutations in imatinib failure patients. We present our data on imatinib resistance mutation analysis (IRMA) and use of imatinib dose hike and 2nd-generation TKI at our institute...
July 2017: Indian Journal of Medical and Paediatric Oncology
Stéphane Verguet, Gillian Tarr, Cindy L Gauvreau, Sujata Mishra, Prabhat Jha, Lingrui Liu, Yue Xiao, Yingpeng Qiu, Kun Zhao
Background: Tobacco taxation and smoke-free workplaces reduce smoking, tobacco-related premature deaths and associated out-of-pocket health care expenditures. We examine the distributional consequences of a price increase in tobacco products through an excise tax hike, and of an implementation of smoke-free workplaces, in China. Methods: We use extended cost-effectiveness analysis (ECEA) to evaluate, across income quintiles of the male population (the large majority of Chinese smokers), the premature deaths averted, the change in tax revenues generated, and the financial risk protection procured (eg, poverty cases averted, defined as the number of individuals no longer facing tobacco-related out-of-pocket expenditures for disease treatment, that would otherwise impoverish them), that would follow a 75% increase in cigarette prices through substantial increments in excise tax fully passed onto consumers, and a nationwide total implementation of workplace smoking bans...
December 2017: Journal of Global Health
(no author information available yet)
No abstract text is available yet for this article.
November 16, 2017: Nature
Per Block, Lauren C Heathcote, Stephanie Burnett Heyes
Complex human behaviour can only be understood within its social environment. However, disentangling the causal links between individual outcomes and social network position is empirically challenging. We present a research design in a closed real-world setting with high-resolution temporal data to understand this interplay within a fundamental human experience - physical pain. Study participants completed an isolated 3-week hiking expedition in the Arctic Circle during which they were subject to the same variation in environmental conditions and only interacted amongst themselves...
November 8, 2017: Social Science & Medicine
Richard Tumminello, Lindsey Glaspey, Anita Bhamidipati, Patrick Sheehan, Sundip Patel
BACKGROUND: Disseminated Lyme disease can be difficult to diagnose, as it begins with nonspecific signs and symptoms, which, if not treated correctly, can lead to atrioventricular conduction blocks and meningitis. In addition, the diagnosis can be further complicated by potentially false-positive test results. CASE REPORT: We report a case of early-disseminated Lyme disease presenting with Borrelia meningitis and concomitant Lyme carditis, which was misdiagnosed as mononucleosis...
October 25, 2017: Journal of Emergency Medicine
David W Jenkins, Alexander Jenks
BACKGROUND: Exercise is highly beneficial for persons with diabetes. Similar to many other patients, those with diabetes may be reluctant to exercise given a lack of motivation and proper instruction regarding an exercise prescription. In general, medical providers are poorly equipped to develop an exercise prescription and furnish motivation. Attempts to find activities that not only provide effective aerobic challenges but also are enjoyable to participate in are fraught with difficulty...
September 2017: Journal of the American Podiatric Medical Association
Eva Sierra Quintana, Carmen María Martínez Caballero, Sara Abigail Batista Pardo, Salas Abella Barraca, María de la Vieja Soriano
OBJECTIVES: To describe the clinical and epidemiologic characteristics of patients with nontraumatic medical problems rescued by a Spanish mountain emergency response service (061 Aragon). MATERIAL AND METHODS: Retrospective observational analysis of records of mountain rescues completed between July 2010 and December 2016. RESULTS: A total of 164 patients with nontraumatic medical emergencies were rescued; 82.3% were males. Most patients were between the ages of 50 and 59 years...
October 2017: Emergencias: revista de la Sociedad Española de Medicina de Emergencias
Ed Silverman
Lawmakers asked seven companies to explain not only "skyrocketing prices," but a practice known as shadow pricing in which a drugmaker increases the price of an existing medicine to match the price hike or higher price set for a new drug launched by another company.
October 2017: Managed Care
João Botelho, Filipa Grosso, Luísa Peixe
Objectives: In Pseudomonas aeruginosa, the blaGES-6 carbapenemase gene was previously associated with an In1076 class I integron. Here, we conducted a genome-based analysis and explored the genetic platform associated with the mobility of this gene. Methods: WGS of a blaGES-6-harbouring P. aeruginosa isolate (FFUP_PS_690) was performed with Illumina HiSeq, de novo assembly was performed using SPAdes and subsequent bioinformatic analysis was performed concerning antibiotic resistance genes, virulence features and mobile genetic elements...
October 4, 2017: Journal of Antimicrobial Chemotherapy
Radhakanta Ghosh, Dhruba P Chatterjee, Sujoy Das, Titas K Mukhopadhyay, Ayan Datta, Arun K Nandi
A significant tuning of optoelectronic properties of polythiophene (PT) chains due to Hofmeister iodide (I(-)) ion is demonstrated in ampholytic polythiophene [polythiophene-g-poly{(N,N,N-trimethylamino iodide)ethyl methacrylate-co-methacrylic acid}, APT] at different pHs. In acidic medium, the absorption and emission signals of PT chromophore exhibit appreciable blue shift in the presence of I(-) as counteranion only. The cooperative effect of undissociated -COOH and quaternary ammonium groups immobilize I(-) near the apolar PT chain causing threading of grafted chains and hence twisting of the backbone attributing to the blue shift...
October 25, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
William T Hentley, Ben Webster, Sophie E F Evison, Michael T Siva-Jothy
Bed bugs have shown a recent and rapid global expansion that has been suggested to be caused by cheap air travel. How a small, flightless and anachoretic insect that hides within its host's sleeping area manages to travel long distances is not yet clear. Bed bugs are attracted to the odour of sleeping humans and we suggest that soiled clothing may present a similarly attractive cue, allowing bed bugs to 'hitch-hike' around the world after aggregating in the laundry bags of travellers. We show that (1) soiled clothing is significantly more attractive than clean clothing to active bed bugs moving within a bedroom sized arena and (2) elevation of CO2 to a level that simulates human occupancy in the same arena appears to initiate search behaviour rather than direct it...
September 28, 2017: Scientific Reports
J Fernando Val-Bernal, Marta Mayorga, Clara Ortega, Emma Linares
Histiocytoid/oncocytic cardiomyopathy (HCM) is a rare, distinctive arrhythmogenic disorder that presents as arrhythmia or sudden death in infants and children. Ventricular noncompaction (VNC) is a rare cardiomyopathy characterized by a thickened endocardial layer of noncompacted myocardium and a thin epicardial layer of compacted myocardium. Only six cases of the association of both cardiomyopathies have been reported previously in the literature. All these cases were in children. To the best of our knowledge, a case of HCM has not been described in the adult...
September 7, 2017: Pathology, Research and Practice
Chun-Yuan Yeh, Christian Schafferer, Jie-Min Lee, Li-Ming Ho, Chi-Jung Hsieh
BACKGROUND: European Union public healthcare expenditure on treating smoking and attributable diseases is estimated at over €25bn annually. The reduction of tobacco consumption has thus become one of the major social policies of the EU. This study investigates the effects of price hikes on cigarette consumption, tobacco tax revenues and smoking-caused deaths in 28 EU countries. METHODS: Employing panel data for the years 2005 to 2014 from Euromonitor International, the World Bank and the World Health Organization, we used income as a threshold variable and applied threshold regression modelling to estimate the elasticity of cigarette prices and to simulate the effect of price fluctuations...
September 21, 2017: BMC Public Health
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