Read by QxMD icon Read


Tucker Harrison, Mo Som, Jeff Stroup
We describe a 60-year-old man who presented with rectal pain and bleeding of a month's duration. His presentation was highly suggestive of lymphogranuloma venereum (LGV) proctitis. Nucleic acid amplification for chlamydia and gonorrhea via rectal swab revealed evidence supportive of anorectal chlamydia. Treatment with doxycycline resulted in complete resolution of his symptoms.
October 2016: Proceedings of the Baylor University Medical Center
Thomas Meyer
The intracellular life style of chlamydia and the ability to cause persistent infections with low-grade replication requires tests with high analytical sensitivity to directly detect C. trachomatis (CT) in medical samples. Nucleic acid amplification tests (NAATs) are the most sensitive assays with a specificity similar to cell culture and are considered the method of choice for CT detection. In addition, NAATs can be performed on various clinical specimens that do not depend on specific transport and storage conditions, since NAATs do not require infectious bacteria...
August 5, 2016: Microorganisms
Meghan Zuck, Ashley Sherrid, Robert Suchland, Tisha Ellis, Kevin Hybiske
Chlamydiae exit via membrane-encased extrusion or through lysis of the host cell. Extrusions are novel, pathogen-containing structures that confer infectious advantages to Chlamydia, and are hypothesized to promote cell-to-cell spread, dissemination to distant tissues and facilitate immune evasion. The extrusion phenomenon has been characterized for several Chlamydia trachomatis serovars, but a thorough investigation of extrusion for additional clinically relevant C. trachomatis strains and Chlamydia species has yet to be performed...
October 2016: Pathogens and Disease
Alex de Voux, James B Kent, Kathryn Macomber, Karen Krzanowski, Dawn Jackson, Tayneata Starr, Sandra Johnson, Deborah Richmond, Lawrence R Crane, Jonathan Cohn, Christopher Finch, Jevon McFadden, Allan Pillay, Cheng Chen, Laurie Anderson, Ellen N Kersh
Lymphogranuloma venereum (LGV) is a sexually transmitted disease (STD) caused by infection with invasive Chlamydia trachomatis serovars L1-L3 (1). LGV is characterized by inguinal and/or femoral lymphadenopathy, typically following a transient, self-limited genital ulcer or papule that might go unnoticed. Rectal infection can result in proctocolitis that can present with mucoid and/or hemorrhagic rectal discharge, anal pain, constipation, fever, and tenesmus, and signs of granulomas and/or ulcerations on anoscopy (1,2)...
2016: MMWR. Morbidity and Mortality Weekly Report
Charussri Leeyaphan, Jason J Ong, Eric P F Chow, Fabian Y S Kong, Jane S Hocking, Melanie Bissessor, Christopher K Fairley, Marcus Chen
Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure...
October 2016: Emerging Infectious Diseases
Claudio Foschi, Nicoletta Banzola, Valeria Gaspari, Antonietta D'Antuono, Roberto Cevenini, Antonella Marangoni
We report the first case of reactive arthritis associated with lymphogranuloma venereum (LGV) in an Italian human immunodeficiency virus-negative woman with urogenital and rectal Chlamydia trachomatis L2 serovar infection. The LGV-associated arthritis has to be considered even when classic symptoms of arthritis are missing and in case of asymptomatic or cryptic LGV localizations.
September 2016: Sexually Transmitted Diseases
Clare Logan, Mike B J Beadsworth, Nick J Beeching
PURPOSE OF REVIEW: The review examines the changing causes and the investigation of infectious and noninfectious diarrhoea in individuals with HIV. RECENT FINDINGS: Despite the excellent prognosis conferred by combination antiretroviral therapy, diarrhoea is still common in HIV-positive individuals and is associated with reduced quality of life and survival. There is increasing interest in the importance of Th17 and Th22 T cells in the maintenance of mucosal immunity within the gut, and in the role of the gut microbiome in gut homeostasis...
October 2016: Current Opinion in Infectious Diseases
Patrick O'Byrne, Paul MacPherson, Stephane DeLaplante, Gila Metz, Andree Bourgault
OBJECTIVE: To review the literature about lymphogranuloma venereum (LGV) and to provide an overview and discussion of practice guidelines. SOURCES OF INFORMATION: The terms Chlamydia trachomatis and lymphogranuloma venereum were searched separately in PubMed. Empirical studies, practice reviews, and clinical guidelines were included. All reference lists were reviewed for additional articles. MAIN MESSAGE: Since 2003, there has been a resurgence of LGV among men who have sex with men in many Western countries, including Canada...
July 2016: Canadian Family Physician Médecin de Famille Canadien
Yongyou Wu, Guangqiang Chen, Pengfei Wu, Jianbin Zhu, Wei Peng, Chungen Xing
BACKGROUND: Precise determination and classification of left gastric vein (LGV) anatomy are helpful in planning for gastric surgery, in particular, for resection of gastric cancer. However, the anatomy of LGV is highly variable. A systematic classification of its variations is still to be proposed. We aimed to investigate the anatomical variations in LGV using CT imaging and develop a new nomenclature system. METHOD: We reviewed CT images and tracked the course of LGV in 825 adults...
July 8, 2016: Surgical and Radiologic Anatomy: SRA
Ryoichi Miyamoto, Satoshi Inagawa, Kentaro Nagai, Michihiro Maeda, Akira Kemmochi, Masayoshi Yamamoto
BACKGROUND: During gastric surgery, precise recognition of the anatomical variations and relationships among gastric tumors and vessels, including the hepatic artery (HA) and left gastric vein (LGV), is required. We utilized a three-dimensional (3D) reconstructed image as a preoperative simulation for gastric surgery. METHODS: We retrospectively analyzed 84 patients who underwent gastrectomy at Tsukuba Medical Center Hospital. This cohort was sequentially divided into a without-3D group (n = 42) and with-3D group (n = 42), and the perioperative outcomes were compared...
2016: SpringerPlus
Boštjan Mlakar, Ana Ramšak
Lymphogranuloma venereum (LGV) is sexually transmitted infection caused by serovars of Chlamydia trachomatis, mostly seen among HIV-positive men who have sex with men. The first three reports of possible LGV in Slovenia were from April to June 2015, followed by a confirmed case of LGV in August 2015. We present the case of an HIV-positive MSM that presented with an anorectal abscess, discharge, lymphadenopathy, and unusual perianal plaque. Gonococcal proctitis was assumed and he received empirical antibiotic treatment, after which only intermittent improvement occurred...
June 2016: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
Cai-Ying Li, Bu-Lang Gao, Bing Song, Qiong-Ying Fan, Li-Xia Zhou, Ping-Yong Feng, Xue-Jing Zhang, Qing-Feng Zhu, Cheng Xiang, Song Peng, Ya-Fei Huang, Hai-Qing Yang
OBJECTIVES: To evaluate the classification and diameter of left gastric vein (LGV) in healthy Chinese adults with multi-detector computed tomography (MDCT). METHODS: MDCT angiography was performed in 234 healthy adults for the portal venous system. CT cross-sectional thin-layer reconstruction combined with maximum intensity projection, volume rendering and multiplanar reconstruction were applied. The diameter of LGV was measured at the point within 2 cm from LGV origination...
September 2016: Postgraduate Medicine
Henry John C de Vries
No abstract text is available yet for this article.
July 2016: Sexually Transmitted Diseases
Alfonso Cabello Úbeda, Ricardo Fernández Roblas, Rosa García Delgado, Laura Martínez García, Fabiola Sterlin, Manuel L Fernández Guerrero, Miguel Górgolas
BACKGROUND: Since 2003, outbreaks of lymphogranuloma venereum (LGV) with anorectal syndrome have been increasingly recognized in many Western countries. All of them have been classified as LGV serovar L2b, mainly occurring in human immunodeficiency virus (HIV)-infected men who have had sex with men (MSM). We describe a series of 26 diagnosed cases of LGV proctitis in downtown Madrid, Spain, in 2014, after implementing routine diagnostic procedures for this disease in symptomatic MSM. METHODS: We conducted an observational study of patients with symptomatic proctitis attending an outpatient infectious diseases clinic in Madrid, Spain during calendar year 2014...
July 2016: Sexually Transmitted Diseases
Soumeya Cherif, Kathir Yoganathan, Susannah Danino
The current resurgence of lymphogranuloma venereum (LGV) has drawn most attention to its potential for causing proctitis; however, this case highlights the need for awareness of LGV as a cause of isolated painful bilateral inguinal lymphadenopathy in a high-risk population and the importance of routine screening for LGV. We describe a case of a 37-year-old HIV positive man, in the population of men who have sex with men (MSM) who presented with bilateral enlarged inguinal lymph nodes and no other symptoms or signs...
June 2, 2016: BMJ Case Reports
Arabella Touati, Chantal Vernay-Vaisse, Michel Janier, Isabelle Le Hen, Cécile Charlois, Philippe Dhotte, Dominique Decré, Cécile Bébéar, Bertille de Barbeyrac
We retrospectively analyzed 1802 nonrectal Chlamydia trachomatis-positive specimens to determine if the L strains responsible for rectal Lymphogranuloma venereum in men who have sex with men could spread to the heterosexual population. No evidence for Lymphogranuloma venereum transmission among heterosexuals in France was observed in 2013. L2b strains seem to be restricted to the men who have sex with men population.
June 2016: Sexually Transmitted Diseases
David J Templeton, Kelly-Anne Ressler, Kirsty Hope, Isobel M Poynten
OBJECTIVES: To investigate an increase in lymphogranuloma venereum (LGV) notifications in New South Wales (NSW). METHODS: Enhanced surveillance of notified LGV cases in NSW between May 2010 and April 2012 using doctor and patient questionnaires. RESULTS: Thirty-seven doctors who had diagnosed 67 (76%) of 88 notified anorectal LGV infections were interviewed. The majority (n=33, 89%) of treating doctors were formally trained and accredited in HIV management and prescribing, and most (n=32, 86%) worked in a public sexual health clinic or a general practice with a high caseload of men who have sex with men (MSM)...
August 2016: Australian and New Zealand Journal of Public Health
F Y S Kong, S N Tabrizi, C K Fairley, S Phillips, G Fehler, M Law, L A Vodstrcil, M Chen, C S Bradshaw, J S Hocking
Repeat rectal chlamydia infection is common in men who have sex with men (MSM) following treatment with 1 g azithromycin. This study describes the association between organism load and repeat rectal chlamydia infection, genovar distribution, and efficacy of azithromycin in asymptomatic MSM. Stored rectal chlamydia-positive samples from MSM were analysed for organism load and genotyped to assist differentiation between reinfection and treatment failure. Included men had follow-up tests within 100 days of index infection...
September 2016: Epidemiology and Infection
Annesu Wessels, Colleen Bamford, David Lewis, Markus Martini, Helen Wainwright
An inguinal lymph node was discovered incidentally during surgery for a suspected strangulated inguinal hernia. The patient had recently been treated for candidal balanoposthitis and was known to have a paraphimosis. A new foreskin ulcer was discovered when he was admitted for the hernia surgery. The lymph node histology showed stellate abscesses suggestive of lymphogranuloma venereum (LGV). Chlamydial serologic tests were negative. As the histological appearance and clinical details provided were thought to suggest LGV, tissue was also sent for a real-time quadriplex polymerase chain reaction assay...
May 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Catherine F Decker
No abstract text is available yet for this article.
August 2016: Disease-a-month: DM
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"