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https://www.readbyqxmd.com/read/29240636/the-etiology-of-genital-ulcer-disease-and-coinfections-with-chlamydia-trachomatis-and-neisseria-gonorrhoeae-in-zimbabwe-results-from-the-zimbabwe-sti-etiology-study
#1
More Mungati, Anna Machiha, Owen Mugurungi, Mufuta Tshimanga, Peter H Kilmarx, Justice Nyakura, Gerald Shambira, Vitalis Kupara, David A Lewis, Elizabeth Gonese, Beth A Tippett Barr, H Hunter Handsfield, Cornelis A Rietmeijer
BACKGROUND: In many countries, sexually transmitted infections (STIs) are treated syndromically. Thus, patients diagnosed as having genital ulcer disease (GUD) in Zimbabwe receive a combination of antimicrobials to treat syphilis, chancroid, lymphogranuloma venereum (LGV), and genital herpes. Periodic studies are necessary to assess the current etiology of GUD and assure the appropriateness of current treatment guidelines. MATERIALS AND METHODS: We selected 6 geographically diverse clinics in Zimbabwe serving high numbers of STI cases to enroll men and women with STI syndromes, including GUD...
January 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29180986/chlamydia-trachomatis-strain-types-have-diversified-regionally-and-globally-with-evidence-for-recombination-across-geographic-divides
#2
Vitaly Smelov, Alison Vrbanac, Eleanne F van Ess, Marlies P Noz, Raymond Wan, Carina Eklund, Tyler Morgan, Lydia A Shrier, Blake Sanders, Joakim Dillner, Henry J C de Vries, Servaas A Morre, Deborah Dean
Chlamydia trachomatis (Ct) is the leading cause of bacterial sexually transmitted diseases worldwide. The Ct Multi Locus Sequence Typing (MLST) scheme is effective in differentiating strain types (ST), deciphering transmission patterns and treatment failure, and identifying recombinant strains. Here, we analyzed 323 reference and clinical samples, including 58 samples from Russia, an area that has not previously been represented in Ct typing schemes, to expand our knowledge of the global diversification of Ct STs...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29175995/cervical-lymphadenopathy-due-to-lymphogranuloma-venereum-infection
#3
Ibrahim Al Busaidi, Danyal Saeed, Isaac I Bogoch
No abstract text is available yet for this article.
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29128125/-diagnostic-issues-of-lymphogranuloma-venereum-a-case-series-of-5%C3%A2-patients
#4
A Fabre-Baudouin, A L Roux, C Marin, M Lachatre, M De Laroche, M Ponsoye, T Hanslik, S Trad
INTRODUCTION: Lymphogranuloma venereum (LG) is a sexually transmitted infection (STI) caused by Chlamydia trachomatis L serovar. METHODS: These five consecutive cases aim to highlight the risk of LG misdiagnosis, in case of initial presentation with isolated inguinal adenitis. RESULTS: Five men (mean age: 30±7 years) were seen in an internal medicine department, for inguinal adenopathy. One patient had clinical signs of urethritis. None presented an associated rectitis...
November 8, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29112398/new-ace-inhibitory-peptides-from-hemp-seed-cannabis-sativa-l-proteins
#5
Lara P Orio, Giovanna Boschin, Teresa Recca, Carlo F Morelli, Laura Ragona, Pierangelo Francescato, Anna Arnoldi, Giovanna Speranza
A hemp seed protein isolate, prepared from defatted hemp seed meals by alkaline solubilization/acid precipitation, was subjected to extensive chemical hydrolysis under acid conditions (6 M HCl). The resulting hydrolysate was fractionated by semipreparative RP-HPLC, and the purified fractions were tested as inhibitors of angiotensin converting enzyme (ACE). Mono- and bidimensional NMR experiments and LC-MS analyses led to the identification of four potentially bioactive peptides, i.e. GVLY, IEE, LGV, and RVR...
November 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29022544/lymphogranuloma-venereum-rates-increased-and-chlamydia-trachomatis-genotypes-changed-among-men-who-have-sex-with-men-in-sweden-2004-2016
#6
Jenny Isaksson, Ola Carlsson, Åsa Airell, Susanne Strömdahl, Göran Bratt, Björn Herrmann
This study aimed to determine the incidence of lymphogranuloma venereum (LGV) in Sweden since 2004 and to study in detail a consecutive number of Chlamydia trachomatis cases in men who have sex with men (MSM) during a 10 month period (September 2014 to July 2015). LGV increased from sporadic import cases in 2004 to comprise a spread within Sweden in 2016. Initially, only the L2b ompA genotype was detected, but in 2015 half of the genotyped LGV cases were L2 genotype. The changing genotype distribution in Sweden is linked to increased LGV spread in Europe...
October 12, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28919303/acquisition-of-wild-type-hiv-1-infection-in-a-patient-on-pre-exposure-prophylaxis-with-high-intracellular-concentrations-of-tenofovir-diphosphate-a-case-report
#7
Elske Hoornenborg, Maria Prins, Roel C A Achterbergh, Lycke R Woittiez, Marion Cornelissen, Suzanne Jurriaans, Neeltje A Kootstra, Peter L Anderson, Peter Reiss, Henry J C de Vries, Jan M Prins, Godelieve J de Bree
BACKGROUND: Pre-exposure prophylaxis (PrEP) with emtricitabine and tenofovir disoproxil fumarate is highly effective against acquisition of HIV infection, and only two cases of infection with a multidrug-resistant virus have been reported under adequate long-term adherence, as evidenced by tenofovir diphosphate concentrations in dried blood spots. We report a case of wild-type HIV-1 infection despite consistent use of emtricitabine and tenofovir disoproxil fumarate. METHODS: The patient participated in the Amsterdam PrEP project, a demonstration project of daily and event-driven PrEP...
September 14, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28876314/laboratory-processes-for-confirmation-of-lymphogranuloma-venereum-infection-during-a-2015-investigation-of-a-cluster-of-cases-in-the-united-states
#8
Ellen N Kersh, Allan Pillay, Alex de Voux, Cheng Chen
In September 2015, the Centers for Disease Control and Prevention were notified of a suspected outbreak investigation of lymphogranuloma venereum (LGV) cases by the Michigan Department of Health and Human Services. The Centers for Disease Control and Prevention offered support with a laboratory-developed polymerase chain reaction test for LGV. This note describes the laboratory workflow and procedures used for the laboratory confirmation of LGV infection.
November 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28809773/a-macaque-model-for-rectal-lymphogranuloma-venereum-and-non-lymphogranuloma-venereum-chlamydia-trachomatis-impact-on-rectal-simian-human-immunodeficiency-virus-acquisition
#9
Sundaram Ajay Vishwanathan, Rachael D Aubert, Monica R Morris, Chunxia Zhao, Christi Philips, George M Khalil, Frank Deyounks, Kristen Kelley, Jana M Ritter, C Y Chen, Ellen N Kersh, Janet M McNicholl
BACKGROUND: Sustained genital tract inflammation caused by sexually transmitted infections (STIs) is known to increase risk of vaginal human immunodeficiency virus (HIV) infections but, to our knowledge, there are no nonhuman primate studies that have evaluated its link to rectal HIV acquisition. METHODS: Rhesus macaques inoculated with Chlamydia trachomatis (CT) (serovars LGV-L2 and CT-E; n = 7) or saline (n = 7) received up to 20 rectal challenges twice a week of simian/HIV immunodeficiency virus (SHIVSF162p3)...
September 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28809772/low-prevalence-of-urethral-lymphogranuloma-venereum-infections-among-men-who-have-sex-with-men-a-prospective-observational-study-sexually-transmitted-infection-clinic-in-amsterdam-the-netherlands
#10
Nynke H N de Vrieze, Bart Versteeg, Sylvia M Bruisten, Martijn S van Rooijen, Jannie J van der Helm, Henry J C de Vries
In contrast to anorectal lymphogranuloma venereum (LGV), few urogenital LGV cases are reported in men who have sex with men. Lymphogranuloma venereum was diagnosed in 0.06% (7/12,174) urine samples, and 0.9% (109/12,174) anorectal samples. Genital-anal transmission seems unlikely the only mode of transmission. Other modes like oral-anal transmission should be considered.
September 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28795162/global-survey-of-mrna-levels-and-decay-rates-of-chlamydia-trachomatis-trachoma-and-lymphogranuloma-venereum-biovars
#11
Rita Ferreira, Vítor Borges, Maria José Borrego, João Paulo Gomes
Interpreting the intricate bacterial transcriptomics implies understanding the dynamic relationship established between de novo transcription and the degradation of transcripts. Here, we performed a comparative overview of gene expression levels and mRNA decay rates for different-biovar (trachoma and lymphogranuloma venereum) strains of the obligate intracellular bacterium Chlamydia trachomatis. By using RNA-sequencing to measure gene expression levels at mid developmental stage and mRNA decay rates upon rifampicin-based transcription blockage, we observed that: i) 60-70% of the top-50 expressed genes encode proteins with unknown function and proteins involved in "Translation, ribosomal structure and biogenesis" for all strains; ii) the expression ranking by genes' functional categories was in general concordant among different-biovar strains; iii) the median of the half-life time (t1/2) values of transcripts were 15-17 min, indicating that the degree of transcripts' stability seems to correlate with the bacterial intracellular life-style, as these values are considerably higher than the ones observed in other studies for facultative intracellular and free-living bacteria; iv) transcript decay rates were highly heterogeneous within each C...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28741042/the-first-case-of-lymphogranuloma-venereum-in-a-woman-in-east-central-europe-and-its-multiple-co-infections
#12
Katerina Juzlova, Filip Rob, Hana Zakoucka, Andrea Kubatova, Zuzana Secnikova, Martina Krasova, Petr Bohac, Jana Hercogova
We are reporting the first case of lymphogranuloma venereum in women in East-Central Europe. A 22-year-old heterosexual woman attended our department of venereology. She complained about a burning sensation in the urethra and vaginal discharge. Many tests were performed, and lymphogranuloma venereum, syphilis, gonorrhea, chlamydial urethritis and cervicitis, genital herpes, genital warts, and hepatitis C were diagnosed. Lymphogranuloma venereum was originally endemic in tropical and subtropical areas, but since 2003, outbreaks of this infection have been reported in North America, Europe, and Australia in men who have sex with men (MSM) community...
July 24, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28722452/-lymphogranuloma-venereum
#13
Michaela Vyšatová
Lymphogranuloma venereum belongs to the sexually transmitted diseases. The disease is caused by Chlamydia trachomatis serotypes L1, L2 and L3. In the beginning of the 21st century there has been observed a large increase in the incidence of this disease in the world. There is a frequent co-occurrence with other sexually transmitted diseases (HIV, syphilis, gonorrhea, hepatitis C). Predominantly this disease affects homosexuals, in which case the first manifestation of the disease may be proctitis or proctocolitis...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28698211/extra-rectal-lymphogranuloma-venereum-in-france-a-clinical-and-molecular-study
#14
Arnaud Desclaux, Arabella Touati, Didier Neau, Cécile Laurier-Nadalié, Cécile Bébéar, Bertille de Barbeyrac, Charles Cazanave
OBJECTIVES: To describe a series of extrarectal lymphogranuloma venereum (LGV) cases diagnosed in France. METHODS: Consecutive LGV cases confirmed at the French Reference Centre for chlamydiae with an extrarectal sample from January 2010 to December 2015 were included. The first part of the study consisted of a retrospective case note review and analysis. In a second part, the complete ompA gene sequence of our samples was determined. RESULTS: There were 56 cases overall: 50 cases of genital LGV and six cases of pharyngeal LGV...
July 11, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28639036/customization-of-laparoscopic-gastric-devascularization-and-splenectomy-for-gastric-varices-based-on-ct-vascular-anatomy
#15
Hirofumi Kawanaka, Tomohiko Akahoshi, Yoshihiro Nagao, Nao Kinjo, Daisuke Yoshida, Yoshihiro Matsumoto, Norifumi Harimoto, Shinji Itoh, Tomoharu Yoshizumi, Yoshihiko Maehara
BACKGROUND: Laparoscopic gastric devascularization(Lap GDS) and splenectomy (SPL) for gastric varices is technically challenging because of highly developed collateral vessels and bleeding tendency. We investigated the feasibility of customization of Lap GDS and SPL based on CT vascular anatomy. METHODS: We analyzed 61 cirrhotic patients with gastric varices who underwent Lap GDS and SPL between 2006 and 2014. Lap GDS was customized according to the afferent feeding veins (left gastric vein (LGV) and/or posterior gastric vein (PGV)/short gastric vein (SGV)) and efferent drainage veins (gastrorenal shunt and/or gastrophrenic shunt, or numerous retroperitoneal veins) based on CT imaging...
June 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28631649/chlamydia-trachomatis-proctitis-masquerading-as-carcinoma-rectum-first-case-report-from-india
#16
Benu Dhawan, Govind Kumar Makharia, Deepak Juyal, Sujeesh Sebastian, Riti Bhatia, Neena Khanna
While proctitis is caused both by infectious and noninfectious causes, infectious causes are acquired typically sexually. Chlamydia trachomatis, which is the most frequent bacterial pathogen causing sexually transmitted infections worldwide, is one of the causative agents of proctitis. We report a case history of a bisexual male who presented to us with rectal bleeding. The colonoscopy showed a nodular ulcerated lesion in the rectum suggestive of rectal malignancy, but biopsies from rectal mass did not reveal malignancy...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28584902/quantitative-trait-loci-analysis-of-melon-cucumis-melo-l-domestication-related-traits
#17
Aurora Díaz, Ana Montserrat Martín-Hernández, Ramón Dolcet-Sanjuan, Ana Garcés-Claver, José María Álvarez, Jordi Garcia-Mas, Belén Picó, Antonio José Monforte
Loci on LGIV, VI, and VIII of melon genome are involved in the control of fruit domestication-related traits and they are candidate to have played a role in the domestication of the crop. The fruit of wild melons is very small (20-50 g) without edible pulp, contrasting with the large size and high pulp content of cultivated melon fruits. An analysis of quantitative trait loci (QTL) controlling fruit morphology domestication-related traits was carried out using an in vitro maintained F2 population from the cross between the Indian wild melon "Trigonus" and the western elite cultivar 'Piel de Sapo'...
June 5, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28580022/value-personality-link-measured-with-novel-instruments-developed-with-an-emic-perspective
#18
Suna Tevrüz, Tülay Turgut, Murat Çinko
The first aim of this study is to investigate whether instruments developed with an emic approach in Turkey produce the same trait-value links obtained with studies using near universal instruments, and if emic traits and value concepts are composed under agency and communal conceptions. So, the first aim of this study is to inspect the conceptual similarities in the links between traits and values. The second aim is to examine the moderating effect of disposable income on the strength of the trait-value relationship...
May 2017: Europe's Journal of Psychology
https://www.readbyqxmd.com/read/28577539/inguinal-and-anorectal-lymphogranuloma-venereum-a-case-series-from-a-sexually-transmitted-disease-center-in-rome-italy
#19
Alessandra Latini, Mauro Zaccarelli, Maria Grazia Paglia, Maria Gabriella Donà, Amalia Giglio, Domenico Moretto, Antonella Vulcano, Massimo Giuliani, Manuela Colafigli, Marina Ambrifi, Fulvia Pimpinelli, Antonio Cristaudo
BACKGROUND: Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by L1, L2, L3 serovars of C. trachomatis (CT). Since 2003, LGV cases have been increasing in Europe. Aim of this report is to describe the LGV cases diagnosed in the largest STI center in Rome, Italy, from 2000 to 2016. This report shows that two clinically and epidemiologically different series of cases exist, and that, at present, the ano-rectal LGV represents the clinical variant occurring more frequently among men having sex with men (MSM), particularly those HIV-infected...
June 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28562672/rapid-detection-and-strain-typing-of-chlamydia-trachomatis-using-a-highly-multiplexed-microfluidic-pcr-assay
#20
Rosemary S Turingan, Ludmila Kaplun, Greice Krautz-Peterson, Sarah Norsworthy, Anna Zolotova, Sandeep J Joseph, Timothy D Read, Deborah Dean, Eugene Tan, Richard F Selden
Nucleic acid amplification tests (NAATs) are recommended by the CDC for detection of Chlamydia trachomatis (Ct) urogenital infections. Current commercial NAATs require technical expertise and sophisticated laboratory infrastructure, are time-consuming and expensive, and do not differentiate the lymphogranuloma venereum (LGV) strains that require a longer duration of treatment than non-LGV strains. The multiplexed microfluidic PCR-based assay presented in this work simultaneously interrogates 13 loci to detect Ct and identify LGV and non-LGV strain-types...
2017: PloS One
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