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Functional connectivity

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https://www.readbyqxmd.com/read/29054087/using-local-knowledge-and-sustainable-transport-to-promote-a-greener-city-the-case-of-bucharest-romania
#1
Mihai R Niță, Denisa L Badiu, Diana A Onose, Athanasios A Gavrilidis, Simona R Grădinaru, Irina I Năstase, Raffaele Lafortezza
Cities undergoing climate change and rapid urbanization are faced with significant transformational processes that affect the environment and society, challenging them to become more sustainable and resilient. The promotion of nature-based solutions represents an efficient approach to meet sustainability targets in cities and improve the quality of life of citizens. The association of large components of green infrastructure, such as urban parks, with physical activity can counteract the sedentary lifestyle endemic to cities and improve the overall health and well-being of individuals (Carrus et al...
October 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/29053955/the-met1-linked-ubiquitin-machinery-emerging-themes-of-de-regulation
#2
REVIEW
Matous Hrdinka, Mads Gyrd-Hansen
The linear ubiquitin chain assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked polyubiquitin (also referred to as linear ubiquitin). A decade after LUBAC was discovered as a cellular activity of unknown function, there are now many lines of evidence connecting Met1-linked polyubiquitin to NF-κB signaling, cell death, inflammation, immunity, and cancer. We now know that Met1-linked polyubiquitin has potent signaling functions and that its deregulation is connected to disease...
October 19, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29053923/loss-and-reformation-of-ruthenium-alkylidene-connecting-olefin-metathesis-catalyst-deactivation-regeneration-and-isomerization
#3
Julien Engel, Wietse Smit, Marco Foscato, Giovanni Occhipinti, Karl W Törnroos, Vidar R Jensen
Ruthenium-based olefin metathesis catalysts are used in laboratory-scale organic synthesis across chemistry, largely thanks to their ease of handling and functional group tolerance. In spite of this robustness, these catalysts readily decompose, via little-understood pathways, to species that promote double-bond migration (isomerization) in both the 1-alkene reagents and the internal-alkene products. We have studied, using density functional theory (DFT), the reactivity of the Hoveyda-Grubbs second-generation catalyst 2 with allylbenzene, and discovered a facile new decomposition pathway...
October 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29053835/abnormal-intrinsic-brain-functional-network-dynamics-in-parkinson-s-disease
#4
Jinhee Kim, Marion Criaud, Sang Soo Cho, María Díez-Cirarda, Alexander Mihaescu, Sarah Coakeley, Christine Ghadery, Mikaeel Valli, Mark F Jacobs, Sylvain Houle, Antonio P Strafella
Parkinson's disease is a neurodegenerative disorder characterized by nigrostriatal dopamine depletion. Previous studies measuring spontaneous brain activity using resting state functional magnetic resonance imaging have reported abnormal changes in broadly distributed whole-brain networks. Although resting state functional connectivity, estimating temporal correlations between brain regions, is measured with the assumption that intrinsic fluctuations throughout the scan are stable, dynamic changes of functional connectivity have recently been suggested to reflect aspects of functional capacity of neural systems, and thus may serve as biomarkers of disease...
October 5, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053778/influence-of-cerebrovascular-disease-on-brain-networks-in-prodromal-and-clinical-alzheimer-s-disease
#5
Joanna Su Xian Chong, Siwei Liu, Yng Miin Loke, Saima Hilal, Mohammad Kamran Ikram, Xin Xu, Boon Yeow Tan, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen, Juan Zhou
Network-sensitive neuroimaging methods have been used to characterize large-scale brain network degeneration in Alzheimer's disease and its prodrome. However, few studies have investigated the combined effect of Alzheimer's disease and cerebrovascular disease on brain network degeneration. Our study sought to examine the intrinsic functional connectivity and structural covariance network changes in 235 prodromal and clinical Alzheimer's disease patients with and without cerebrovascular disease. We focused particularly on two higher-order cognitive networks-the default mode network and the executive control network...
September 19, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053724/accounting-for-the-complex-hierarchical-topology-of-eeg-phase-based-functional-connectivity-in-network-binarisation
#6
Keith Smith, Daniel Abásolo, Javier Escudero
Research into binary network analysis of brain function faces a methodological challenge in selecting an appropriate threshold to binarise edge weights. For EEG phase-based functional connectivity, we test the hypothesis that such binarisation should take into account the complex hierarchical structure found in functional connectivity. We explore the density range suitable for such structure and provide a comparison of state-of-the-art binarisation techniques, the recently proposed Cluster-Span Threshold (CST), minimum spanning trees, efficiency-cost optimisation and union of shortest path graphs, with arbitrary proportional thresholds and weighted networks...
2017: PloS One
https://www.readbyqxmd.com/read/29053459/a-neurodynamic-approach-to-distributed-optimization-with-globally-coupled-constraints
#7
Xinyi Le, Sijie Chen, Zheng Yan, Juntong Xi
In this paper, a distributed neurodynamic approach is proposed for constrained convex optimization. The objective function is a sum of local convex subproblems, whereas the constraints of these subproblems are coupled. Each local objective function is minimized individually with the proposed neurodynamic optimization approach. Through information exchange between connected neighbors only, all nodes can reach consensus on the Lagrange multipliers of all global equality and inequality constraints, and the decision variables converge to the global optimum in a distributed manner...
October 18, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/29053453/distributed-continuous-time-algorithms-for-resource-allocation-problems-over-weight-balanced-digraphs
#8
Zhenhua Deng, Shu Liang, Yiguang Hong
In this paper, a distributed resource allocation problem with nonsmooth local cost functions is considered, where the interaction among agents is depicted by strongly connected and weight-balanced digraphs. Here the decision variable of each agent is within a local feasibility constraint described as a convex set, and all the decision variables have to satisfy a network resource constraint, which is the sum of available resources. To solve the problem, a distributed continuous-time algorithm is developed by virtue of differentiated projection operations and differential inclusions, and its convergence to the optimal solution is proved via the set-valued LaSalle invariance principle...
October 17, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/29053298/hyperinvariant-tensor-networks-and-holography
#9
Glen Evenbly
We propose a new class of tensor network state as a model for the AdS/CFT correspondence and holography. This class is demonstrated to retain key features of the multiscale entanglement renormalization ansatz (MERA), in that they describe quantum states with algebraic correlation functions, have free variational parameters, and are efficiently contractible. Yet, unlike the MERA, they are built according to a uniform tiling of hyperbolic space, without inherent directionality or preferred locations in the holographic bulk, and thus circumvent key arguments made against the MERA as a model for AdS/CFT...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053273/distinguishing-nitro-vs-nitrito-coordination-in-cytochrome-c-using-vibrational-spectroscopy-and-density-functional-theory
#10
Zach N Nilsson, Brian L Mandella, Kakali Sen, Demet Kekilli, Michael A Hough, Pierre Moënne-Loccoz, Richard W Strange, Colin R Andrew
Nitrite coordination to heme cofactors is a key step in the anaerobic production of the signaling molecule nitric oxide (NO). An ambidentate ligand, nitrite has the potential to coordinate via the N- (nitro) or O- (nitrito) atoms in a manner that can direct its reactivity. Distinguishing nitro vs nitrito coordination, along with the influence of the surrounding protein, is therefore of particular interest. In this study, we probed Fe(III) heme-nitrite coordination in Alcaligenes xylosoxidans cytochrome c' (AXCP), an NO carrier that excludes anions in its native state but that readily binds nitrite (Kd ∼ 0...
October 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29053141/loss-of-bim-increases-mitochondrial-oxygen-consumption-and-lipid-oxidation-reduces-adiposity-and-improves-insulin-sensitivity-in-mice
#11
Jibran A Wali, Sandra Galic, Christina Yr Tan, Esteban N Gurzov, Ann E Frazier, Timothy Connor, Jingjing Ge, Evan G Pappas, David Stroud, L Chitra Varanasi, Claudia Selck, Michael T Ryan, David R Thorburn, Bruce E Kemp, Balasubramanian Krishnamurthy, Thomas Wh Kay, Sean L McGee, Helen E Thomas
BCL-2 proteins are known to engage each other to determine the fate of a cell after a death stimulus. However, their evolutionary conservation and the many other reported binding partners suggest an additional function not directly linked to apoptosis regulation. To identify such a function, we studied mice lacking the BH3-only protein BIM. BIM(-/-) cells had a higher mitochondrial oxygen consumption rate that was associated with higher mitochondrial complex IV activity. The consequences of increased oxygen consumption in BIM(-/-) mice were significantly lower body weights, reduced adiposity and lower hepatic lipid content...
October 20, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29052948/association-of-participant-preferences-on-work-and-school-participation-after-a-first-episode-of-psychosis
#12
Alexandra de Waal, Lisa B Dixon, Jennifer L Humensky
AIM: To explore baseline ratings of importance (ROI) across life domains for participants in the Recovery After an Initial Schizophrenia Episode Connection Program (RAISE CP), and investigate whether ratings were correlated with intervention outcomes over time. METHODS: At baseline, 63 participants rated the importance of reducing symptoms, side-effects, confusion, increasing energy and school/work functioning and improving social relations. ROIs were examined in relation to work/school participation (n = 41) and occupational functioning (n = 37) after 12 months...
October 20, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29052845/the-advanced-glycation-end-product-n-%C3%AF%C2%B5-carboxymethyllysine-and-its-precursor-glyoxal-increase-serotonin-release-from-caco-2-cells
#13
Ann-Katrin Holik, Barbara Lieder, Nicole Kretschy, Mark M Somoza, Jakob P Ley, Joachim Hans, Veronika Somoza
Advanced glycation end products (AGEs), comprising a highly diverse class of Maillard reaction compounds formed in vivo and during heating processes of foods, have been described in the progression of several degenerative conditions such as Alzheimer's disease and diabetes mellitus. N(ϵ) -Carboxymethyllysine (CML) represents a well-characterized AGE, which is frequently encountered in a Western diet and is known to mediate its cellular effects through binding to the receptor for AGEs (RAGE). Since very little is known about the impact of exogenous CML and its precursor, glyoxal, on intestinal cells, a genome-wide screening using a customized microarray was conducted in fully differentiated Caco-2 cells...
October 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29052616/pregenual-anterior-cingulate-dysfunction-associated-with-depression-in-ocd-an-integrated-multimodal-fmri-1-h-mrs-study
#14
Reza Tadayonnejad, Rangaprakash Deshpande, Olusola Ajilore, Teena Moody, Francesca Morfini, Ronald Ly, Joseph O'Neill, Jamie D Feusner
Depression is a commonly-occurring symptom in obsessive-compulsive disorder (OCD), and is associated with worse functional impairment, poorer quality of life, and poorer treatment response. Understanding the underlying neurochemical and connectivity-based brain mechanisms of this important symptom domain in OCD is necessary for development of novel, more globally effective treatments. To investigate biopsychological mechanisms of comorbid depression in OCD, we examined effective connectivity and neurochemical signatures in the pregenual anterior cingulate cortex (pACC), a structure known to be involved in both OCD and depression...
October 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29052550/an-input-to-state-stability-approach-to-verify-almost-global-stability-of-a-synchronous-machine-infinite-bus-system
#15
Johannes Schiffer, Denis Efimov, Romeo Ortega, Nikita Barabanov
Conditions for almost global stability of an operating point of a realistic model of a synchronous generator with constant field current connected to an infinite bus are derived. The analysis is conducted by employing the recently proposed concept of input-to-state stability (ISS)-Leonov functions, which is an extension of the powerful cell structure principle developed by Leonov and Noldus to the ISS framework. Compared with the original ideas of Leonov and Noldus, the ISS-Leonov approach has the advantage of providing additional robustness guarantees...
August 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29052279/combining-protein-sequence-structure-and-dynamics-a-novel-approach-for-functional-evolution-analysis-of-pas-domain-superfamily
#16
Zheng Dong, Hongyu Zhou, Peng Tao
OBJECTIVES: PAS domains are widespread in archaea, bacteria and eukaryota, and play important roles in various functions. In this study, we aim to explore functional evolutionary relationship among proteins in the PAS domain superfamily in view of the sequence-structure-dynamics-function relationship. METHODS: We collected protein sequences and crystal structures data from RCSB Protein Data Bank of the PAS domain superfamily belonging to three biological functions (nucleotide binding, photoreceptor activity and transferase activity)...
October 20, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29052140/prion-protein-family-contributes-to-tumorigenesis-via-multiple-pathways
#17
Xiaowen Yang, Zhijun Cheng, Lihua Zhang, Guiru Wu, Run Shi, Zhenxing Gao, Chaoyang Li
A wealth of evidence suggests that proteins from prion protein (PrP) family contribute to tumorigenesis in many types of cancers, including pancreatic ductal adenocarcinoma (PDAC), breast cancer, glioblastoma, colorectal cancer, gastric cancer, melanoma, etc. It is well documented that PrP is a biomarker for PDAC, breast cancer, and gastric cancer. However, the underlying mechanisms remain unclear. The major reasons for cancer cell-caused patient death are metastasis and multiple drug resistance, both of which connect to physiological functions of PrP expressing in cancer cells...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29052102/changes-in-cerebellar-functional-connectivity-and-autonomic-regulation-in-cancer-patients-treated-with-the-neuro-emotional-technique-for-traumatic-stress-symptoms
#18
Daniel A Monti, Anna Tobia, Marie Stoner, Nancy Wintering, Michael Matthews, Chris J Conklin, Feroze B Mohamed, Inna Chervoneva, Andrew B Newberg
PURPOSE: A growing number of research studies have implicated the cerebellum in emotional processing and regulation, especially with regard to negative emotional memories. However, there currently are no studies showing functional changes in the cerebellum as a result of treatment for traumatic stress symptoms. The Neuro Emotional Technique (NET) is an intervention designed to help improve symptoms related to traumatic stress using an integrative approach that combines emotional, cognitive, and motor processing, with a particular focus on autonomic nervous system regulation...
October 19, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29051952/insights-into-human-intrinsically-disordered-proteins-from-their-gene-expression-profile
#19
Arup Panda, Debarun Acharya, Tapash Chandra Ghosh
Expression level provides important clues about gene function. Previously, various efforts have been undertaken to profile human genes according to their expression level. Intrinsically disordered proteins (IDPs) do not adopt any rigid conformation under physiological conditions, however, are considered as an important functional class in all domains of life. Based on a human tissue-averaged gene expression level, previous studies showed that IDPs are expressed at a lower level than ordered globular proteins...
October 20, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/29051903/the-anterolateral-complex-of-the-knee
#20
Elmar Herbst, Marcio Albers, Jeremy M Burnham, Freddie H Fu, Volker Musahl
BACKGROUND: Significant controversy exists regarding the anterolateral structures of the knee. PURPOSE: To determine the layer-by-layer anatomic structure of the anterolateral complex of the knee. STUDY DESIGN: Descriptive laboratory study. METHODS: Twenty fresh-frozen cadaveric knees (age range, 38-56 years) underwent a layer-by-layer dissection to systematically expose and identify the various structures of the anterolateral complex...
October 2017: Orthopaedic Journal of Sports Medicine
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