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https://www.readbyqxmd.com/read/29143983/growth-of-doxorubicin-resistant-undifferentiated-spindle-cell-sarcoma-pdox-is-arrested-by-metabolic-targeting-with-recombinant-methioninase
#1
Kentaro Igarashi, Shukuan Li, Qinghong Han, Yuying Tan, Kei Kawaguchi, Takashi Murakami, Tasuku Kiyuna, Kentaro Miyake, Yunfeng Li, Scott D Nelson, Sarah M Dry, Arun S Singh, Irmina A Elliott, Tara A Russell, Mark A Eckardt, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya, Fritz C Eilber, Robert M Hoffman
Undifferentiated spindle-cell sarcoma (USCS) is a recalcitrant -cancer in need of individualized therapy. A high-grade USCS from a striated muscle of a patient was grown orthotopically in the right biceps femoris muscle of nude mice to establish a patient-derived orthotopic xenograft (PDOX) model. In a previous study, we evaluated the efficacy of standard first-line chemotherapy of doxorubicin (DOX), gemcitabine (GEM) combined with docetaxel (DOC), compared to pazopanib (PAZ), a multi-targeting tyrosine-kinase inhibitor, in an USCS PDOX model...
November 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29143379/region-dependent-hamstrings-activity-in-nordic-hamstring-exercise-and-stiff-leg-deadlift-defined-with-high-density-emg
#2
András Hegyi, Annamária Péter, Taija Finni, Neil J Cronin
Recent studies suggest region-specific metabolic activity in hamstring muscles during injury prevention exercises, but the neural representation of this phenomenon is unknown. The aim of this study was to examine whether regional differences are evident in the activity of biceps femoris long head (BFlh) and semitendinosus (ST) muscles during two common injury prevention exercises. Twelve male participants without a history of hamstring injury performed the Nordic hamstring exercise (NHE) and stiff-leg deadlift (SDL) while BFlh and ST activity were recorded with high-density electromyography (HD-EMG)...
November 15, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29138040/ultrasound-finding-of-ischiofemoral-impingement-syndrome-and-novel-treatment-with-botulinum-toxin-chemodenervation-a-case-report
#3
Yin-Ting Chen, Keyonna M Jenkins
Ischiofemoral impingement syndrome (IFIS) is a rare and poorly understood condition that leads to deep gluteal pain, groin, and/or medial thigh pain. It has unique diagnostic challenges, with limited non-operative treatment options. It is caused by the impingement of the quadratus femoris by the lesser trochanter and the ischium. Currently there are no validated physical examination maneuvers for IFIS, and the value of ischiofemoral interval for establishing IFIS is also uncertain. Ultrasound-guided corticosteroid injections have been reported...
November 11, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29137900/the-posterior-capsular-ligamentous-complex-contributes-to-hip-joint-stability-in-distraction
#4
Masaki Takao, Yoshito Otake, Norio Fukuda, Yoshinobu Sato, Mehran Armand, Nobuhiko Sugano
BACKGROUND: Laxity of soft tissues after total hip arthroplasty is considered to be a cause of accelerated wear of bearing surfaces and dislocation. The purpose of this study is to assess the contribution of the anterior and posterior capsular ligamentous complexes and the short external rotators, except the quadratus femoris, on the stability of the hip against axial traction. METHODS: The study subjects comprised 7 fresh cadavers with 12 normal hip joints. In 6 hips, soft tissues surrounding the hip joint were resected in the following order to simulate the anterior approach: anterior capsule, posterior capsule, piriformis, conjoined tendon, and external obturator...
November 11, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29137565/mri-evaluation-of-the-acl-remnant-tissue-in-acl-deficient-knee
#5
Tsuneari Takahashi, Masashi Kimura, Katsushi Takeshita
PURPOSE: To clarify the relationship between anterior cruciate ligament (ACL) remnant tissue at the time of surgery and preoperative evaluation of ACL-injured knee. METHODS: A total of 123 patients were enrolled and classified into four groups based on the classification of ACL remnant tissue. To quantify the signal-noise quotient (SNQ), five regions of interest (ROIs), such as tibial, mid, femoral ACL remnant, tendon of quadriceps femoris to normalize the signal intensity of ACL remnant tissue, and background measurements, were measured...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29128629/influence-of-emotional-stimuli-on-lower-limb-cutaneous-reflexes-during-human-gait
#6
Martin Zaback, Brian C Horslen, Taylor W Cleworth, Laurel Collins, Cécile Langlet, J Timothy Inglis, Mark G Carpenter
Previous research has shown that cutaneous reflexes are modulated when walking with a threat to stability. It is unclear if this reflex modulation is purely related to the context of the imposed threat or if emotional changes associated with the threat exert an independent influence on reflex excitability. This study investigated the influence of emotional stimuli on lower limb cutaneous reflexes during treadmill walking. Twenty-eight healthy young adults walked at a self-selected pace while viewing pictures that manipulated emotional arousal and valence (confirmed with electrodermal and self-report measures)...
November 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29121524/eating-quality-traits-of-shoulder-roast-and-stir-fry-cuts-outperformed-loin-and-silverside-cuts-sourced-from-entire-and-immunocastrated-male-pigs
#7
H A Channon, D N D'Souza, F R Dunshea
This study investigated the effects of ageing period (2 or 7days), endpoint temperature (70 or 75°C), cut type (loin (M. longissimus thoracis et lumborum), silverside (M. biceps femoris), blade (M. triceps brachii) and chuck tender (M. supraspinatus)), cooking method (roast and stir fry (all cuts) and steak (loin only)) on eating quality attributes of pork from entire and immunocastrated male pigs. Higher intramuscular fat levels were found in all cuts from immunocastrated males compared with entire males...
October 31, 2017: Meat Science
https://www.readbyqxmd.com/read/29121510/emg-normalization-method-based-on-grade-3-of-manual-muscle-testing-within-and-between-day-reliability-of-normalization-tasks-and-application-to-gait-analysis
#8
Anne Tabard-Fougère, Kevin Rose-Dulcina, Vincent Pittet, Romain Dayer, Nicolas Vuillerme, Stéphane Armand
Electromyography (EMG) is an important parameter in Clinical Gait Analysis (CGA), and is generally interpreted with timing of activation. EMG amplitude comparisons between individuals, muscles or days need normalization. There is no consensus on existing methods. The gold standard, maximum voluntary isometric contraction (MVIC), is not adapted to pathological populations because patients are often unable to perform an MVIC. The normalization method inspired by the isometric grade 3 of manual muscle testing (isoMMT3), which is the ability of a muscle to maintain a position against gravity, could be an interesting alternative...
November 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29121248/fusion-of-positron-emission-tomography-computed-tomography-with-magnetic-resonance-imaging-reveals-hamstring-peritendonitis-in-polymyalgia-rheumatica
#9
Claire E Owen, Aurora M T Poon, Sze Ting Lee, Lee Pheng Yap, Richard B Zwar, Christine M McMenamin, Simon K L Lam, David F L Liew, Kunthi Pathmaraj, Andrew Kemp, Andrew M Scott, Russell R C Buchanan
Objectives: To characterize 18F-fluorodeoxyglucose (18F-FDG) uptake on whole-body PET/CT in PMR, and identify its precise anatomic correlate using MRI. Methods: Patients with newly diagnosed PMR according to the 2012 EULAR/ACR classification criteria were prospectively recruited. Participants with GCA were excluded. A whole-body 18F-FDG PET/CT scan was performed in all untreated patients. Qualitative and semiquantitative [standardized uptake value maximum (SUVmax)] scoring of abnormal 18F-FDG uptake was undertaken...
November 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29120776/comparative-proteomic-profiling-of-myofibrillar-proteins-in-dry-cured-ham-with-different-proteolysis-indices-and-adhesiveness
#10
M López-Pedrouso, C Pérez-Santaescolástica, D Franco, E Fulladosa, J Carballo, C Zapata, J M Lorenzo
Excessive proteolysis during dry-cured ham processing may lead to high adhesiveness and consumer dissatisfaction. The aim of this research is to identify biomarkers for proteolysis and adhesiveness. Two hundred biceps femoris porcine muscle samples from Spanish dry-cured ham were firstly evaluated for various physicochemical parameters, including their proteolysis indices and instrumental adhesiveness. Proteins of samples with extreme proteolysis indices were separated by two-dimensional electrophoresis and identified by tandem mass spectrometry (MALDI-TOF/TOF)...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29119953/-the-influence-of-non-invasive-electrical-stimulation-of-the-spinal-cord-on-the-locomotor-function-of-patients-presenting-with-movement-disorders-of-central-genesis
#11
M V Balykin, R N Yakupov, V V Mashin, E Yu Kotova, Yu M Balykin, Yu P Gerasimenko
AIM: The objective of the present study was to evaluate the influence of non-invasive (transcutaneous) electrical spinal cord stimulation on the locomotor function of the patients suffering from movement disorders. PATIENTS AND METHODS: The study involved 10 patients of both sexes at the age from 32 to 70 years (including 40% of men and 60% of women) presenting with the compromised locomotor function of varying severity associated with the disturbances of cerebral blood circulation caused either by an injury to the brain and spinal cord or by stroke...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29118955/effect-of-electrical-stimulation-on-motor-nerve-regeneration-in-sciatic-nerve-ligated-mice
#12
Farzaneh Samiee, Mohammad-Reza Zarrindast
The purpose of this study was to investigate the effect of electrical stimulation on sciatic nerve regeneration and functional recovery of target muscles. Mice were randomly divided into 3 groups: ligated without electrical stimulation, ligated with electrical stimulation and control (non-ligated). The unilateral peripheral mononeuropathy was produced on the right hind limb. Sciatic nerve was then electrically stimulated daily for a period of 2 weeks (duration: 0.2 msec, frequency: 100Hz, amplitude: 15mA). Evoked surface EMG was recorded from biceps femoris (BF) and gluteus maximus (GM) muscles on the 3rd, 7th, 10th and 14th day after sciatic nerve ligation...
June 27, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29118716/etiology-and-recovery-of-neuromuscular-fatigue-following-competitive-soccer-match-play
#13
Callum G Brownstein, Jack P Dent, Paul Parker, Kirsty M Hicks, Glyn Howatson, Stuart Goodall, Kevin Thomas
Aim: Previous research into the etiology of neuromuscular fatigue following competitive soccer match-play has primarily focused on peripheral perturbations, with limited research assessing central nervous system function in the days post-match. The aim of the present study was to examine the contribution and time-course of recovery of central and peripheral factors toward neuromuscular fatigue following competitive soccer match-play. Methods: Sixteen male semi-professional soccer players completed a 90-min soccer match...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29118698/an-acute-exposure-to-muscle-vibration-decreases-knee-extensors-force-production-and-modulates-associated-central-nervous-system-excitability
#14
Robin Souron, Thibault Besson, Chris J McNeil, Thomas Lapole, Guillaume Y Millet
Local vibration (LV) has been recently validated as an efficient training method to improve muscle strength. Understanding the acute effects may help elucidate the mechanism(s). This study aimed to investigate the effects of a single bout of prolonged LV on knee extensor force production and corticospinal responsiveness of vastus lateralis (VL) and rectus femoris (RF) muscles in healthy young and old adults. Across two visits, 23 adult subjects (20-75 years old) performed pre- and post-test measurements, separated by 30-min of either rest (control; CON) or LV...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29117442/neuromuscular-adaptations-induced-by-adjacent-joint-training
#15
Ryoichi Ema, Itaru Saito, Ryota Akagi
Effects of resistance training are well known to be specific to tasks that are involved during training. However, it remains unclear whether neuromuscular adaptations are induced after adjacent joint training. This study examined the effects of hip flexion training on maximal and explosive knee extension strength and neuromuscular performance of the rectus femoris (RF, hip flexor and knee extensor) compared with the effects of knee extension training. Thirty-seven untrained young men were randomly assigned to hip flexion training, knee extension training, or a control group...
November 8, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29116573/an-evidence-based-framework-for-strengthening-exercises-to-prevent-hamstring-injury
#16
REVIEW
Matthew N Bourne, Ryan G Timmins, David A Opar, Tania Pizzari, Joshua D Ruddy, Casey Sims, Morgan D Williams, Anthony J Shield
Strength training is a valuable component of hamstring strain injury prevention programmes; however, in recent years a significant body of work has emerged to suggest that the acute responses and chronic adaptations to training with different exercises are heterogeneous. Unfortunately, these research findings do not appear to have uniformly influenced clinical guidelines for exercise selection in hamstring injury prevention or rehabilitation programmes. The purpose of this review was to provide the practitioner with an evidence-base from which to prescribe strengthening exercises to mitigate the risk of hamstring injury...
November 7, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29112966/lengthening-of-knee-flexor-muscles-by-percutaneous-needle-tenotomy-description-of-the-technique-and-preliminary-results
#17
Alexis Schnitzler, François Genêt, Aurélie Diebold, Laurence Mailhan, Claire Jourdan, Philippe Denormandie
BACKGROUND: Knee flexion contractures occur frequently in non-ambulatory, aged persons and persons with central nervous system lesions, rendering positioning and nursing care difficult. There are often risks associated with surgical interventions. OBJECTIVE: To evaluate the effectiveness of percutaneous needle tenotomy to lengthen the knee flexor muscles and improve passive function. METHODS: This was a retrospective study of all patients who underwent percutaneous needle tenotomy between 2012 and 2014...
2017: PloS One
https://www.readbyqxmd.com/read/29108918/donor-site-morbidity-of-the-anterolateral-thigh-flap
#18
Hannes Weise, Andreas Naros, Gunnar Blumenstock, Michael Krimmel, Sebastian Hoefert, Susanne Kluba, Stefan Hofer, Siegmar Reinert
INTRODUCTION: The purpose of this study was to investigate donor site morbidity after reconstruction of defects in the head and neck region with an anterolateral thigh (ALT) flap. METHODS: From 07/2006 to 12/2015 the anterolateral thigh flap was used for reconstruction of large intra- or extraoral defects in 138 patients. The donor sites were available to examine for morbidity in 51 patients (36.7%). All patients completed a standardized questionnaire, received a physical examination, and underwent isokinetic muscle exercises of the lower extremity with a Dynamometer...
September 30, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29102877/different-fatigue-resistant-leg-muscles-and-emg-response-during-whole-body-vibration
#19
Deniz Simsek
The purpose of this study was to determine the effects of static whole-body vibration (WBV) on the Electromyograhic (EMG) responses of leg muscles, which are fatigue-resistant in different manner. The study population was divided into two groups according to the values obtained by the Fatigue Index [Group I: Less Fatigue Resistant (LFR), n=11; Group II: More Fatigue Resistant (MFR), n=11]. The repeated electromyographic (EMG) activities of four leg muscles were analyzed the following determinants: (1) frequency (30 Hz, 35 Hz and 40 Hz); (2) stance position (static squat position); (3) amplitude (2 mm and 4 mm) and (4) knee flexion angle (120°), (5) vertical vibration platform...
October 19, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29101912/effect-of-hip-joint-angle-on-concentric-knee-extension-torque
#20
Ryoichi Ema, Taku Wakahara, Yasuo Kawakami
This study tested the hypothesis that the effect of hip joint angle on concentric knee extension torque depends on knee joint angle during a single knee extension task. Twelve men performed concentric knee extensions in fully extended and 80° flexed hip positions with maximal effort. The angular velocities were set at 30° s(-1) and 180° s(-1). The peak torque and torques attained at 30°, 50°, 70° and 90° (anatomical position = 0°) of the knee joint were compared between the two hip positions...
October 26, 2017: Journal of Electromyography and Kinesiology
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