G Meloni, A Proia, F Mauro, P Amaranto, S Capria, G Cimino, I Cordone, P de Fabritiis, C Rapanotti, G Reato, M Vignetti, R Foa, F Mandelli
BACKGROUND AND OBJECTIVES: To investigate the feasibility of peripheral blood stem cell (PBSC) transplantion in patients with high-risk chronic lymphocytic leukemia (CLL) in remission after fludarabine therapy, the clinical impact of minimal residual disease (MRD) monitoring and the immunologic reconstitution after transplantation. DESIGN AND METHODS: Twenty CLL patients, in clinical complete remission (CR) after fludarabine, were offered an unmanipulated PBSC transplant and were longitudinally monitored for MRD and immunologic reconstitution...
September 2000: Haematologica