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Keywords blood cell cordon transplant i...

blood cell cordon transplant in leukemia

https://read.qxmd.com/read/36030305/concurrent-zrsr2-mutation-and-tet2-loss-promote-myelodysplastic-neoplasm-in-mice
#1
JOURNAL ARTICLE
Cristian Garcia-Ruiz, Cristina Martínez-Valiente, Lourdes Cordón, Alessandro Liquori, Raúl Fernández-González, Eva Pericuesta, Juan Sandoval, José Cervera, Alfonso Gutiérrez-Adán, Alejandra Sanjuan-Pla
RNA splicing and epigenetic gene mutations are the most frequent genetic lesions found in patients with myelodysplastic neoplasm (MDS). About 25% of patients present concomitant mutations in such pathways, suggesting a cooperative role in MDS pathogenesis. Importantly, mutations in the splicing factor ZRSR2 frequently associate with alterations in the epigenetic regulator TET2. However, the impact of these concurrent mutations in hematopoiesis and MDS remains unclear. Using CRISPR/Cas9 genetically engineered mice, we demonstrate that Zrsr2m/m Tet2-/- promote MDS with reduced penetrance...
August 27, 2022: Leukemia
https://read.qxmd.com/read/12579343/effect-of-cryopreservation-on-in-vitro-clonal-growth-of-cordonal-blood-cells
#2
JOURNAL ARTICLE
Laura Del Pup, Sergio De Angeli, Maria Teresa Conconi, Claudio Grandi, Pier Giorgio Gamba, Pier Paolo Parnigotto, Gastone G Nussdorfer
Cordonal blood (CB) is today recognized as a potentially important source of hematopoietic stem cells (SCs) for allogeneic transplantation, and to this task it would be of extreme importance to have the possibility of using cryopreserved CB units. Hence we investigated whether freezing and thawing alter the viability of CB hematopoietic cells. Mononuclear cells, recovered from fresh CB units by density-gradient centrifugation, were partly frozen and then thawed and partly immediately utilized for clonogenic tests...
March 2003: International Journal of Molecular Medicine
https://read.qxmd.com/read/11142491/acute-myeloid-leukemia-and-lung-cancer-occurring-in-a-chronic-lymphocytic-leukemia-patient-treated-with-fludarabine-and-autologous-peripheral-blood-stem-cell-transplantation
#3
JOURNAL ARTICLE
G Meloni, A Proia, V Guerrisi, I Cordone, R De Cuia, S Fenu, F R Mauro, E Pescarmona, G Reato, F Mandelli
An increased incidence of different malignancies associated to chronic lymphocytic leukemia (CLL) has been reported. The association of CLL and acute leukemia is a rare event described in < 1% of CLL, the type of acute leukemia being either from the lymphoid or more often from the myeloid lineage. The coexistence of acute myeloid leukemia (AML) and CLL in the same patient has been occasionally reported. Most of these cases have been associated with the administration of chemotherapy or radiotherapy for CLL, suggesting that the former may be a secondary leukemia...
November 2000: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://read.qxmd.com/read/10980634/unmanipulated-peripheral-blood-stem-cell-autograft-in-chronic-lymphocytic-leukemia-clinical-findings-and-biological-monitoring
#4
JOURNAL ARTICLE
G Meloni, A Proia, F Mauro, P Amaranto, S Capria, G Cimino, I Cordone, P de Fabritiis, C Rapanotti, G Reato, M Vignetti, R Foa, F Mandelli
BACKGROUND AND OBJECTIVES: To investigate the feasibility of peripheral blood stem cell (PBSC) transplantion in patients with high-risk chronic lymphocytic leukemia (CLL) in remission after fludarabine therapy, the clinical impact of minimal residual disease (MRD) monitoring and the immunologic reconstitution after transplantation. DESIGN AND METHODS: Twenty CLL patients, in clinical complete remission (CR) after fludarabine, were offered an unmanipulated PBSC transplant and were longitudinally monitored for MRD and immunologic reconstitution...
September 2000: Haematologica
https://read.qxmd.com/read/9688287/evaluation-of-marrow-and-blood-haemopoietic-progenitors-in-chronic-lymphocytic-leukaemia-before-and-after-chemotherapy
#5
JOURNAL ARTICLE
R Sala, F R Mauro, R Bellucci, M S De Propris, I Cordone, A Lisci, R Foà, P de Fabritiis
We have evaluated the number and differentiation pattern of CD34+ cells, as well as the CFU-GM, BFU-E and CFU-GEMM progenitors from the blood (PB) and marrow (BM) of 53 chronic lymphocytic leukaemia (CLL) patients. Twenty-four patients were untreated and 29 were studied at 2 months from the last course of fludarabine or chlorambucil; 6 patients, studied after fludarabine therapy, were further evaluated after mobilization with cyclophosphamide and G-CSF. PB of untreated patients showed a median number of CD34+ cells, CFU-GM, BFU-E and CFU-GEMM/10(5) seeded cells and per litre of PB similar to those of normal controls...
July 1998: European Journal of Haematology
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