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https://www.readbyqxmd.com/read/29909564/organized-screening-detects-breast-cancer-at-earlier-stage-regardless-of-molecular-phenotype
#1
Claire M B Holloway, Li Jiang, Marlo Whitehead, Jennifer M Racz, Patti A Groome
PURPOSE: Mortality reduction attributable to organized breast screening is modest. Screening may be less effective at detecting more aggressive cancers at an earlier stage. This study was conducted to determine the relative efficacy of screening mammography to detect cancers at an earlier stage by molecular phenotype. METHODS: We identified 2882 women with primary invasive breast cancer diagnosed between January 1, 2008 and December 31, 2012 and who had a mammogram through the Ontario Breast Screening Program in the 28 months before diagnosis...
June 16, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29907248/micro-rna-181a-suppresses-progestin-promoted-breast-cancer-cell-growth
#2
Muqing Gu, Lijuan Wang, Chun Yang, Xue Li, Chanwei Jia, Stephane Croteau, Xiangyan Ruan, Pierre Hardy
BACKGROUND: Recent investigations have indicated that hormone therapy may increase the risk of breast cancer (BC), and the addition of synthetic progestins may play a critical role in this. Several studies have pointed out the important role of progesterone receptor membrane component 1 (PGRMC1) in the development of BC, especially with hormone therapy using progestins. Although the deregulation of microRNA-181a (miR-181a) is often associated with human BC, the effect of miR-181a on PGRMC1 expression during hormone therapy has not been investigated...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29904427/association-of-serum-interleukin-10-interleukin-17a-and-transforming-growth-factor-%C3%AE-levels-with-human-benign-and-malignant-breast-diseases
#3
Zhuangwei Lv, Min Liu, Jinghui Shen, Dong Xiang, Yunfeng Ma, Yanhong Ji
Interleukin-10 (IL-10), interleukin-17A (IL-17A) and transforming growth factor α (TGF-α) have been implicated in the progression of breast cancer. However, the diagnostic and prognostic roles of these cytokines in ductal carcinoma remain unclear. The present study therefore aimed to determine the serum levels of IL-10, IL-17 and TGF-α in subjects with benign and malignant breast diseases and to evaluate the clinical significance of these cytokines in ductal carcinoma. Pre-operative serum samples were collected from 378 patients with breast disease and 70 healthy subjects...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29902579/androgen-receptor-expression-is-a-favorable-prognostic-factor-in-triple-negative-breast-cancers
#4
Tao Zuo, Parker Wilson, Ali Fuat Cicek, Malini Harigopal
Androgen receptor (AR) expression is an emerging prognostic marker that has been observed in 25% to 75% of triple negative breast cancers (TNBCs) that lack estrogen receptor, progesterone receptor and HER2 overexpression. TNBCs are treated with AR-targeted therapies and standardized evaluation of AR expression may help guide patient management. Basal-like TNBCs are a subgroup of TNBCs defined by positive immunoreactivity for CK5/6 or EGFR that carry a worse prognosis. However, it's unclear whether basal-like TNBCs have a different rate of AR positivity or if AR expression is predictive of disease free survival in this patient group...
June 11, 2018: Human Pathology
https://www.readbyqxmd.com/read/29902578/the-impact-of-the-effectiveness-of-gata3-as-a-prognostic-factor-in-breast-cancer
#5
Fararjeh-Salah Abdul Fattah, Shih-Hsin Tu, Li-Ching Chen, Yun-Ru Liu, Yen-Kuang Lin, Hang-Lung Chang, Hui-Wen Chang, Chih-Hsiung Wu, Wendy-Hwang Verslues, Yuan-Soon Ho
The transcription factor GATA3 plays a significant role in mammary gland development and differentiation. We analyzed expression of GATA3 in breast cancer (BC) cell lines and clinical specimens from BC patients in Taiwan. Semi-quantitative reverse transcriptase (RT)-polymerase chain reaction (PCR), quantitative real-time PCR carried out to determine the mRNA level of GATA3 from 241 pairs of matched tumor and adjacent normal tissues from anonymous female donors. GATA3 immunohistochemistry (IHC) staining and H-score were performed (n=25)...
June 11, 2018: Human Pathology
https://www.readbyqxmd.com/read/29899747/high-densities-of-tumor-associated-plasma-cells-predict-improved-prognosis-in-triple-negative-breast-cancer
#6
Joe Yeong, Jeffrey Chun Tatt Lim, Bernett Lee, Huihua Li, Noel Chia, Clara Chong Hui Ong, Weng Kit Lye, Thomas Choudary Putti, Rebecca Dent, Elaine Lim, Aye Aye Thike, Puay Hoon Tan, Jabed Iqbal
Breast cancer is the most common malignancy affecting women, but the heterogeneity of the condition is a significant obstacle to effective treatment. Triple negative breast cancers (TNBCs) do not express HER2 or the receptors for estrogen or progesterone, and so often have a poor prognosis. Tumor-infiltrating T cells have been well-characterized in TNBC, and increased numbers are associated with better outcomes; however, the potential roles of B cells and plasma cells have been large. Here, we conducted a retrospective correlative study on the expression of B cell/plasma cell-related genes, and the abundance and localization of B cells and plasma cells within TNBCs, and clinical outcome...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29893312/correlation-of-proliferative-index-with-various-clinicopathologic-prognostic-parameters-in-primary-breast-carcinoma-a-study-from-north-india
#7
Nisha Marwah, Ashima Batra, Sanjay Marwah, Veena Gupta, Samta Shakya, Rajeev Sen
Aim: Routine assessment of cell proliferation is recommended in the pathologic evaluation for all breast cancers. Considering the poor reproducibility and interobserver variability in mitotic counts, Ki-67 is an easily available and reliable substitute for mitotic counts and has been shown to have a significant relationship with the histologic grade of malignancy and the mitotic activity of tumors. Our study aimed at exploring Ki-67 expression and studying its correlation with other established prognostic parameters...
April 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29890463/hpv-infection-and-breast-cancer-results-of-a-microarray-approach
#8
Andriana Kouloura, Electra Nicolaidou, Ioannis Misitzis, Euaggelia Panotopoulou, Vasilios Smyrniotis, Giovanni Corso, Paolo Veroneci, Nikolaos Arkadopoulos
OBJECTIVES: Human papilloma virus (HPV) has been implicated in several types of epithelial cancer. The role of HPV in breast carcinogenesis has been a matter of debate fueled by conflicting reports in recent years. The aim of this study is to identify the prevalence of breast and cervical HPV infection in cancer patients by using a modern microarray approach. MATERIALS AND METHODS: In the present prospective study, 201 breast cancer patients were included. For each patient a detailed medical history was taken and during the operation, under sterile conditions, samples were collected, from the tumour, the healthy adjacent breast tissue and any positive sentinel lymph nodes...
June 4, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29889754/management-strategy-for-breast-cancer-in-pregnancy
#9
Kelly Kuo, Aaron B Caughey
A 34-year-old primigravid woman presents for a routine prenatal visit at 18 weeks of gestation with a breast lump. On examination, she has a painless, firm breast mass measuring 3-4 cm in diameter with overlying skin dimpling. A diagnostic mammogram shows findings suspicious for malignancy (Breast Imaging Reporting and Data System [BI-RADS] 4), and core biopsy demonstrates an invasive ductal carcinoma with both estrogen and progesterone receptor-positive staining. The patient asks: "How will this affect my pregnancy, and what is the safest course of action?"...
June 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29886409/can-3-0-tesla-diffusion-tensor-imaging-parameters-be-prognostic-indicators-in-breast-cancer
#10
Safiye Tokgoz Ozal, Ercan Inci, Aysegul Akdogan Gemici, Hurriyet Turgut, Murat Cikot, Mehmet Karabulut
PURPOSE: To investigate the relationship between diffusion tensor imaging (DTI) parameters such as fractional anisotropy (FA), mean diffusivity (MD), relative anisotropy (RA), and volume ratio (VR) values, and prognostic factors of invasive breast cancer. MATERIALS AND METHODS: This retrospective study examined 63 patients with pathologically confirmed invasive breast cancers. The patients underwent pre-operative diffusion-weighted magnetic resonance imaging (MRI) at 3...
April 5, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29885789/inducing-or-preventing-subsequent-malignancies-for-breast-cancer-survivors-double-edged-sword-of-estrogen-receptor-and-progesterone-receptor
#11
Zhe-Yu Hu, Huawu Xiao, Mengjia Xiao, Yu Tang, Jian Sun, Ze-Ming Xie, Quchang Ouyang
INTRODUCTION: Hormone receptor and human epidermal growth factor receptor 2 (HER2) status is important for breast cancer (BC) treatment. Previous studies have shown that the long-term treatment outcomes of BC are significantly impaired by the development of subsequent malignancies. Therefore, in the present study, we evaluated the effect of hormone receptor/HER2 status on subsequent malignancies in breast cancer survivors. METHODS AND MATERIALS: The Surveillance, Epidemiology, and End Results*Stat database (8...
April 19, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29881286/clinicopathologic-features-and-radiation-therapy-utilization-in-patients-with-male-breast-cancer-a-national-cancer-database-study
#12
REVIEW
Joshua Weir, Yan Daniel Zhao, Terence Herman, Özer Algan
Male breast cancer (MBC) accounts for approximately 1% of all breast cancers, limiting the data characterizing clinicopathologic features and treatment outcomes in patients with MBC. This paucity of data has led to most of our treatment guidance being extrapolated from patients with female breast cancer (FBC). From 1998 to 2012, data were captured using the National Cancer Database to identify patients with nonmetastatic MBC (n = 23 305) and FBC (n = 2 678 061). Tumor and clinicopathologic features were obtained and compared...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29877575/brca1-associated-mammary-tumorigenesis-is-dependent-on-estrogen-rather-than-progesterone-signaling
#13
Marieke van de Ven, Xiaoling Liu, Eline van der Burg, Sjoerd Klarenbeek, Xanthippi Alexi, Wilbert Zwart, Fred Dijcks, Peter Bouwman, Jos Jonkers
Hereditary breast cancers in BRCA1-mutation carriers are mostly estrogen receptor alpha (ERα) and progesterone receptor (PR) negative, however, hormone depletion via bilateral oophorectomy does result in a marked reduction of breast cancer risk, suggesting that BRCA1-associated breast tumorigenesis is dependent on hormone signaling. We used genetically engineered mouse models to dissect the individual influences of ERα and PR signaling in the development of BRCA1-deficient breast cancer. In line with the human data, BRCA1-deficient mouse mammary tumors are ERα-negative and bilateral ovariectomy leads to abrogation of mammary tumor development...
June 7, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29875927/descriptive-study-of-triple-negative-breast-cancer-in-eastern-algeria
#14
Haddad Souad, Frimeche Zahia, Lakehal Abdelhak, Sifi Karima, Satta Dalila, Abadi Noureddine
Introduction: Triple-negative breast cancer (TNBC) is characterized by the lack of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 (HER-2) expression. It is aggressive and most common in African women. In this study we identified the frequency, clinical an pathological characteristics of this type in a cohort of women in Eastern Algeria. Methods: We conducted a retrospective study between January 2010 and December 2015 at the regional hospital of Constantine in eastern Algeria...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29868978/rna-seq-of-circulating-tumor-cells-in-stage-ii-iii-breast-cancer
#15
Julie E Lang, Alexander Ring, Tania Porras, Pushpinder Kaur, Victoria A Forte, Neal Mineyev, Debu Tripathy, Michael F Press, Daniel Campo
BACKGROUND: We characterized the whole transcriptome of circulating tumor cells (CTCs) in stage II-III breast cancer to evaluate correlations with primary tumor biology. METHODS: CTCs were isolated from peripheral blood (PB) via immunomagnetic enrichment followed by fluorescence-activated cell sorting (IE/FACS). CTCs, PB, and fresh tumors were profiled using RNA-seq. Formalin-fixed, paraffin-embedded (FFPE) tumors were subjected to RNA-seq and NanoString PAM50 assays with risk of recurrence (ROR) scores...
June 4, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29860761/-the-effect-of-axillary-lymph-node-status-on-the-prognosis-of-patients-with-local-regional-recurrence-after-breast-conserving-surgery
#16
Z Zhang, W Zhang, Z J Li, X M Wang, X C Cao, C H Xiao
Objective: To investigate the effect of axillary lymph node status in evaluating the prognosis of patients with local recurrence after breast-conserving surgery. Methods: The clinical data of 72 patients with local-regional recurrence who had undergone breast-conserving therapy in Tianjin Cancer Hospital from February 2001 to December 2009 were collected and retrospectively analyzed. These patients were divided into axillary lymph node positive group (23 cases) and negative group (49 cases), according to their axillary lymph node status...
May 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29849791/therapeutic-potential-of-bcl-x-l-mcl-1-synthetic-inhibitor-jy-1-106-and-retinoids-for-human-triple-negative-breast-cancer-treatment
#17
Mariarita Perri, Jeremy L Yap, Steven Fletcher, Erika Cione, Maureen A Kane
Overexpression of anti-apoptotic proteins belonging to the B cell lymphoma (Bcl)-2 family is observed in numerous cancer types and has been postulated to promote cancer cell survival and chemotherapy resistance. Bcl-extra large (xL) /myeloid cell leukemia sequence (Mcl)-1 was demonstrated to be expressed at relatively high levels in clinically aggressive basal-like cancers and inhibiting Bcl-xL overexpression could potentially provoke cell death. A molecule able to target Bcl-xL /Mcl-1, JY-1-106, is herein under investigation...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29848724/factors-predictive-of-sentinel-lymph-node-involvement-in-primary-breast-cancer
#18
Wolfram Malter, Martin Hellmich, Mayhar Badian, Verena Kirn, Peter Mallmann, Stefan Krämer
BACKGROUND/AIM: Sentinel lymph node biopsy (SLNB) has replaced axillary lymph node dissection (ALND) for axillary staging in patients with early-stage breast cancer. The need for therapeutic ALND is the subject of ongoing debate especially after the publication of the ACOSOG Z0011 trial. In a retrospective trial with univariate and multivariate analyses, factors predictive of sentinel lymph node involvement should be analyzed in order to define tumor characteristics of breast cancer patients, where SLNB should not be spared to receive important indicators for adjuvant treatment decisions (e...
June 2018: Anticancer Research
https://www.readbyqxmd.com/read/29848684/the-role-of-chi3l1-expression-in-angiogenesis-in-invasive-ductal-breast-carcinoma
#19
Agnieszka Rusak, Karolina Jablonska, Aleksandra Piotrowska, Jedrzej Grzegrzolka, Aleksandra Nowak, Andrzej Wojnar, Piotr Dziegiel
BACKGROUND/AIM: An increased level of chitinase 3 like 1 protein (CHI3L1) expression is observed in patients with cancer and may have potential prognostic value. The aim of this study was to evaluate the role of CHI3L1 in angiogenesis in invasive ductal breast carcinoma (IDC) (n=110). MATERIALS AND METHODS: Immunohistochemistry was used to assess the expression of CHI3L1, CD31, CD34, vascular endothelial growth factor (VEGFA, VEGFC and VEGFD). Real-time polymerase chain reaction and western blot were used to determine the level of CHI3L1 mRNA and protein...
June 2018: Anticancer Research
https://www.readbyqxmd.com/read/29848327/immunotherapeutic-interventions-of-triple-negative-breast-cancer
#20
REVIEW
Zehuan Li, Yiran Qiu, Weiqi Lu, Ying Jiang, Jin Wang
Triple Negative Breast Cancer (TNBC) is a highly heterogeneous subtype of breast cancer that lacks the expression of oestrogen receptors, progesterone receptors and human epidermal growth factor receptor 2. Although TNBC is sensitive to chemotherapy, the overall outcomes of TNBC are worse than for other breast cancers, and TNBC is still one of the most fatal diseases for women. With the discovery of antigens specifically expressed in TNBC cells and the developing technology of monoclonal antibodies, chimeric antigen receptors and cancer vaccines, immunotherapy is emerging as a novel promising option for TNBC...
May 30, 2018: Journal of Translational Medicine
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