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https://www.readbyqxmd.com/read/28829241/construction-and-immunogenicity-analysis-of-whole-gene-mutation-dna-vaccine-of-aleutian-mink-virus-isolated-virulent-strain
#1
Dongxu Liu, Jianming Li, Kun Shi, Fanli Zeng, Ying Zong, Xue Leng, Huijun Lu, Rui Du
Aleutian mink disease (AD) is a chronic viral infection that causes autoimmune disorders in minks and presents a significant economic burden on mink farming. Despite the substantial challenges presented by AD, no effective vaccine is available and only partial protection has been achieved. We constructed a whole-gene nucleic acid vaccine from an isolated virulent Aleutian mink disease virus (ADV) strain (pcDNA3.1-ADV). Based on this whole-gene nucleic acid vaccine, we generated truncated mutant constructs by removing portions of the ADV VP2 gene using overlap extension polymerase chain reaction...
August 22, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28822432/-clinical-analysis-of-children-with-pertussis-and-significance-of-respiratory-virus-detection-in-the-combined-diagnosis
#2
H Huang, L Deng, F Xiao, J Fu, J Deng, F Wang, J Yang
Objective: To analyze the clinical data of children with pertussis and explore the necessity of respiratory virus detection in the combined diagnosis so as to improve the clinician's understanding and standardize the diagnosis and treatment of pertussis in children. Method: Clinical data and laboratory examination of 195 suspected pertussis children between Jan. 2015 and Dec. 2016 in Children's Hospital Affiliated to Capital Institute of Pediatric were analyzed retrospectively. Result: The nasopharyngeal secretions were collected from 195 suspected pertussis children, PCR was employed to detect the nucleic acid of Bordetella pertussis...
August 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28819561/factors-associated-with-the-decrease-in-hepatitis-b-surface-antigen-titers-following-interferon-therapy-in-patients-with-chronic-hepatitis-b-is-interferon-and-adefovir-combination-therapy-effective
#3
Yoshihiko Yano, Yasushi Seo, Hiroki Hayashi, Yuri Hatazawa, Hirotaka Hirano, Akihiro Minami, Yuki Kawano, Masaya Saito, Toshiaki Ninomiya, Masahiko Sugano, Hajime Yamada, Naoto Kitajima, Seitetsu Yoon, Yoshitake Hayashi
The purpose of antiviral therapy in chronic hepatitis B (CHB) is generally to achieve a decrease and ultimately disappearance of HBs antigen (HBsAg). Interferon (IFN) therapy of CHB appears to be less effective in Asian countries than in European countries, and the advantage of IFN and nucleotide(s) analog (NA) combination therapy has yet to be fully investigated. The present study focused on the factors associated with a decrease in HBs antigen following IFN monotherapy or IFN + NA combination therapy. A total of 35 patients with CHB who received IFN-based therapy (mean ± standard deviation age 36...
September 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28496468/a-simple-and-specific-stability-indicating-rp-hplc-method-for-routine-assay-of-adefovir-dipivoxil-in-bulk-and-tablet-dosage-form
#4
Bahar Darsazan, Alireza Shafaati, Seyed Alireza Mortazavi, Afshin Zarghi
A simple and reliable stability-indicating RP-HPLC method was developed and validated for analysis of adefovir dipivoxil (ADV).The chromatographic separation was performed on a C18 column using a mixture of acetonitrile-citrate buffer (10 mM at pH 5.2) 36:64 (%v/v) as mobile phase, at a flow rate of 1.5 mL/min. Detection was carried out at 260 nm and a sharp peak was obtained for ADV at a retention time of 5.8 ± 0.01 min. No interferences were observed from its stress degradation products. The method was validated according to the international guidelines...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28452097/neutrophil-gelatinase-associated-lipocalin-accurately-predicts-renal-tubular-injury-in-patients-with-chronic-hepatitis-b-administered-with-nucleos-t-ide-analogs
#5
Yao Zhang, Jing Li, Fahong Li, Xun Qi, Jiming Zhang
AIM: Little is currently known regarding the impact on tubular function in patients with chronic hepatitis B (CHB) under long-term use of nucleos(t)ide analogs. Previous studies showed that neutrophil gelatinase-associated lipocalin (NGAL) elevation was associated with renal tubular injury. We evaluated renal function markers and bone mineral density (BMD) in patients treated long-term with adefovir dipivoxil (ADV) or entecavir (ETV). METHODS: In this cross-sectional study,we enrolled 78 patients (ADV: 36, ETV: 42), and 21 patients matched for age, observation time, and baseline estimated glomerular filtration rate (eGFR) from each group...
April 28, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28209721/the-cumulative-burden-of-double-stranded-dna-virus-detection-after-allogeneic-hct-is-associated-with-increased-mortality
#6
Joshua A Hill, Bryan T Mayer, Hu Xie, Wendy M Leisenring, Meei-Li Huang, Terry Stevens-Ayers, Filippo Milano, Colleen Delaney, Mohamed L Sorror, Brenda M Sandmaier, Garrett Nichols, Danielle M Zerr, Keith R Jerome, Joshua T Schiffer, Michael Boeckh
Strategies to prevent active infection with certain double-stranded DNA (dsDNA) viruses after allogeneic hematopoietic cell transplantation (HCT) are limited by incomplete understanding of their epidemiology and clinical impact. We retrospectively tested weekly plasma samples from allogeneic HCT recipients at our center from 2007 to 2014. We used quantitative PCR to test for cytomegalovirus, BK polyomavirus, human herpesvirus 6B, HHV-6A, adenovirus, and Epstein-Barr virus between days 0 and 100 post-HCT. We evaluated risk factors for detection of multiple viruses and association of viruses with mortality through day 365 post-HCT with Cox models...
April 20, 2017: Blood
https://www.readbyqxmd.com/read/28127204/phase-iib-trial-of-in-vivo-electroporation-mediated-dual-plasmid-hepatitis-b-virus-dna-vaccine-in-chronic-hepatitis-b-patients-under-lamivudine-therapy
#7
RANDOMIZED CONTROLLED TRIAL
Fu-Qiang Yang, Gui-Rong Rao, Gui-Qiang Wang, Yue-Qi Li, Yao Xie, Zhan-Qing Zhang, Cun-Liang Deng, Qing Mao, Jun Li, Wei Zhao, Mao-Rong Wang, Tao Han, Shi-Jun Chen, Chen Pan, De-Ming Tan, Jia Shang, Ming-Xiang Zhang, Yue-Xin Zhang, Ji-Ming Yang, Guang-Ming Chen
AIM: To assess the efficacy and safety of in vivo electroporation (EP)-mediated dual-plasmid hepatitis B virus (HBV) DNA vaccine vs placebo for sequential combination therapy with lamivudine (LAM) in patients with chronic hepatitis B. METHODS: Two hundred and twenty-five patients were randomized to receive either LAM + vaccine (vaccine group, n = 109) or LAM + placebo (control group, n = 116). LAM treatment lasted 72 wk. Patients received the DNA vaccine or placebo by intramuscular injection mediated by EP at weeks 12 (start of treatment with vaccine or placebo, SOT), 16, 24, and 36 (end of treatment with vaccine or placebo, EOT)...
January 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27676570/p2-36-nivolumab-nivo-in-patients-pts-with%C3%A2-advanced-adv-nsclc-and-central%C3%A2-nervous-system-cns-metastases-mets-track-immunotherapy
#8
Jonathan W Goldman, Lucio Crino, Everett E Vokes, Esther Holgado, Karen Reckamp, Adam Pluzanski, David Spigel, Martin Kohlhaeufl, Marina Garassino, Laura Qm Chow, Scott Gettinger, David E Gerber, Libor Havel, Suresh S Ramalingam, Grace K Dy, William J Geese, Ang Li, Anne Blackwood-Chirchir, Diane Healey, Julie Brahmer, Gilberto Lopes
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27672391/antiviral-therapy-in-lamivudine-resistant-chronic-hepatitis-b-patients-a-systematic-review-and-network-meta-analysis
#9
REVIEW
Hui-Lian Wang, Xi Lu, Xudong Yang, Nan Xu
The relative efficacy of different strategies for chronic hepatitis B (CHB) patients with lamivudine resistance (LAM-R) has not yet been systematically studied. Clinical trials were searched in PUBMED, MEDLINE, EMBASE, and CNKI databases up to February 15, 2016. Nine trials including 764 patients met the entry criteria. In direct meta-analysis, TDF showed a stronger antiviral effect than any one of ETV, LAM/ADV, and ADV against LAM-R hepatitis B virus. LAM/ADV therapy was superior to ADV in suppressing viral replication...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27362576/long-term-results-of-the-monocusp-valve-formation-in-the-common-femoral-vein-in-patients-with-avalvular-deep-veins-of-the-lower-extremities
#10
Igor M Ignatyev, Rustem V Akhmetzyanov
BACKGROUND: Aim of the study was to evaluate the long-term results of the monocusp valve formation in the common femoral vein (CFV) in patients with avalvular deep veins (ADV) of the lower extremities. METHODS: A total of 36 patients (24 women and 12 men) at the age varying from 37 to 58 years old were given surgical treatment during the period from 2008 to 2014. Six patients presented with congenital ADV, while the remaining 30 ADV had a consequence of the post-thrombotic lesion in the valves with the complete recanalization and manifested deep venous axial reflux...
April 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/27283294/totally-robotic-reversal-of-omega-loop-gastric-bypass-to-normal-anatomy
#11
Fabian Reche, Adrian Mancini, Anne-Laure Borel, Jean-Luc Faucheron
BACKGROUND: Gastric bypass procedures can potentially lead to middle and long-term complications (Podnos et al. Arch Surg 138(9):957-61, 2003). For several years, Roux-en-Y gastric bypass reversal procedures performed by laparotomy or laparoscopic way have been described in literature (Moon et al. Surg Obes Relat Dis 11(4):821-6, 2015). Major complications are anastomotic ulcers, anastomotic complications or functional disorder such as dumping syndrome, hypocalcemia, severe hypoglycemia, and malnutrition (Moon et al...
August 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27069711/comparison-between-first-and-second-generation-cryoballoon-for-paroxysmal-atrial-fibrillation-ablation
#12
Sergio Conti, Massimo Moltrasio, Gaetano Fassini, Fabrizio Tundo, Stefania Riva, Antonio Dello Russo, Michela Casella, Benedetta Majocchi, Vittoria Marino, Pasquale De Iuliis, Valentina Catto, Salvatore Pala, Claudio Tondo
Introduction. Cryoballoon (CB) ablation has emerged as a novel treatment for pulmonary vein isolation (PVI) for patients with paroxysmal atrial fibrillation (PAF). The second-generation Arctic Front Advance (ADV) was redesigned with technical modifications aiming at procedural and outcome improvements. We aimed to compare the efficacy of the two different technologies over a long-term follow-up. Methods. A total of 120 patients with PAF were enrolled. Sixty patients underwent PVI using the first-generation CB and 60 patients with the ADV catheter...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27010199/genome-analysis-of-four-old-world-monkey-adenoviruses-supports-the-proposed-species-classification-of-primate-adenoviruses-and-reveals-signs-of-possible-homologous-recombination
#13
Iva I Podgorski, Laura Pantó, Tibor Papp, Balázs Harrach, Mária Benkö
Within the family Adenoviridae, presently Simian mastadenovirus A is the single species approved officially for monkey adenoviruses (AdVs), whilst the establishment of six further species (Simian mastadenovirus B to Simian mastadenovirus G) has been proposed in the last few years. We examined the genetic content and phylogenetic relationships of four Old World monkey (OWM) AdV types [namely simian AdV (SAdV)-8, -11, -16 and -19] for which it had been proposed that they should be classified into different AdV species: SAdV-11 to Human mastadenovirus G, and the other three viruses into three novel species...
July 2016: Journal of General Virology
https://www.readbyqxmd.com/read/26605310/characterization-of-acute-respiratory-infections-among-340-infants-in-wuxi-jiangsu-province
#14
Xiaoli Ge, Zhijun Han, Hongmin Chen, Juanjuan Cheng, Mingzhu Gao, Haibin Sun
BACKGROUND: To investigate the etiological and epidemiological features of acute respiratory infections among children in Wuxi, Jiangsu Province. METHODS: Nasopharyngeal swab specimens were collected from 340 pediatric patients from Wuxi Second People's Hospital from June 2012 to May 2014. Seven respiratory viruses including influenza virus A (FA), influenza virus B (FB), parainfluenza virus I (PIVI), parainfluenza virus II (PIVII), parainfluenza virus III (PIVIII), adenovirus (ADV), and respiratory syncytial virus (RSV) were detected using direct immunofluorescence method...
October 2015: Annals of Translational Medicine
https://www.readbyqxmd.com/read/26478678/management-of-entecavir-resistant-chronic-hepatitis-b-with-adefovir-based-combination-therapies
#15
Hyoung Su Kim, Hyung Joon Yim, Myoung Kuk Jang, Ji Won Park, Sang Jun Suh, Yeon Seok Seo, Ji Hoon Kim, Bo Hyun Kim, Sang Jong Park, Sae Hwan Lee, Sang Gyune Kim, Young Seok Kim, Jung Il Lee, Jin-Woo Lee, In Hee Kim, Tae Yeob Kim, Jin-Wook Kim, Sook-Hyang Jeong, Young Kul Jung, Hana Park, Seong Gyu Hwang
AIM: To evaluate the long-term efficacy adefovir (ADV)-based combination therapies in entecavir (ETV)-resistant chronic hepatitis B (CHB) patients. METHODS: Fifty CHB patients with genotypic resistance to ETV at 13 medical centers in South Korea were included for the analysis. All the patients received rescue therapy with the combination of ADV plus ETV (ADV/ETV, n = 23) or ADV plus lamivudine (LMV) (ADV/LMV, n = 27) for more than 12 mo. Patients were monitored at least every 3-4 mo during ADV-based combination therapy by clinical examination as well as biochemical and virological assessments...
October 14, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26447622/-adefovir-dipivoxil-effects-on-and-related-factors-of-blood-phosphorus-metabolism-in-patients-with-chronic-hepatitis-b
#16
Huibin Ning, Kuan Li, Wei Li, Gangqiang Ding, Erhui Xiao, Zhongshan Mao, Yi Kang, Jia Shang
OBJECTIVE: To investigate the effects of adefovir dipivoxil (ADV) on blood phosphorus metabolism in patients with chronic hepatitis B (CHB). METHODS: Patients with hepatitis B surface antigen (HBsAg)-positive CHB were treated with ADV alone, ADV combined with interferon (IFN), or ADV combined with lamivudine (LAM). Changes in levels of calcium, phosphate, urea, and creatinine were assessed at treatment weeks 4, 12, 24, 48, 72 and 96. Statistical analysis was carried out with SPSS 16 software; influential factors were analyzed by ANOVA and non-conditional logistic regression analysis...
August 2015: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/26184280/adenovirus-36-and-obesity-an-overview
#17
REVIEW
Eleonora Ponterio, Lucio Gnessi
There is an epidemic of obesity starting about 1980 in both developed and undeveloped countries definitely associated with multiple etiologies. About 670 million people worldwide are obese. The incidence of obesity has increased in all age groups, including children. Obesity causes numerous diseases and the interaction between genetic, metabolic, social, cultural and environmental factors are possible cofactors for the development of obesity. Evidence emerging over the last 20 years supports the hypothesis that viral infections may be associated with obesity in animals and humans...
July 2015: Viruses
https://www.readbyqxmd.com/read/26055076/longitudinal-investigation-of-adenovirus-36-seropositivity-and-human-obesity-the-cardiovascular-risk-in-young-finns-study
#18
MULTICENTER STUDY
M A Sabin, D Burgner, R L Atkinson, Z Pei-Lun Lee, C G Magnussen, M Cheung, M Kähönen, T Lehtimäki, E Jokinen, T Laitinen, N Hutri-Kähönen, J S A Viikari, M Juonala, O T Raitakari
BACKGROUND/OBJECTIVES: Adenovirus-36 (Adv-36) infection is associated with exaggerated adipogenesis in cell culture and the development of obesity in animal models and humans, but a causal relationship remains unproven. Our objective was to determine whether serological evidence of Adv-36 infection in childhood and/or adulthood is associated with adult obesity. SUBJECTS/METHODS: Paired plasma concentrations of Adv-36 antibodies were measured by a novel enzyme-linked immunosorbent assay in a subgroup (n=449) of the Cardiovascular Risk in Young Finns Study in childhood (mean age 11...
November 2015: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/26005376/delayed-reduction-of-hepatitis-b-viral-load-and-dynamics-of-adefovir-resistant-variants-during-adefovir-plus-entecavir-combination-rescue-therapy
#19
Yang Wang, Shuang Liu, Yu Chen, Sujun Zheng, Li Zhou, Fengmin Lu, Zhongping Duan
OBJECTIVE: Entecavir (ETV) added to adefovir (ADV) is recommended in the consensus for management of patients with ADV resistance. However, little attention has been focused on the delayed reduction of HBV DNA and dynamics of ADV-resistant variants during ADV-ETV combination rescue therapy in the clinical setting. We characterized the dynamics of viral load and resistant variants in nucleos(t)ide analogues (NAs)-naïve chronic hepatitis B (CHB) patients during antiviral treatment with ADV monotherapy followed by ADV-ETV combination therapy...
2015: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/25983054/a-novel-baseline-hepatitis-b-virus-sequencing-based-strategy-for-predicting-adefovir-antiviral-response
#20
Yu-Wei Wang, Xuefeng Shan, Yao Huang, Haijun Deng, Wen-Xiang Huang, Da-Zhi Zhang, Juan Chen, Ni Tang, You-Lan Shan, Jin-Jun Guo, Ailong Huang
Adefovir dipivoxil (ADV) is used as first-line monotherapy or rescue therapy in chronic hepatitis B (CHB) patients. In this study, we sought to identify nucleotide changes in the reverse transcriptase (RT) of hepatitis B virus (HBV) at baseline and explore their predictive value for ADV antiviral response. Ultra-deep pyrosequencing (UDPS) was utilized to determine HBV genetic variability within the RT region at baseline and during a 48-week ADV therapy. According to the viral load at the end of ADV treatment, all patients were classified into responders (HBV DNA level reduction of ⩾ 3 log 10 IU/mL) and suboptimal responders (HBV DNA level reduction of <3 log 10 IU/mL)...
July 2015: Infection, Genetics and Evolution
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