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Neonatal jaundice and immunoglobulin

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https://www.readbyqxmd.com/read/27459953/use-of-intravenous-immunoglobulin-in-neonates-at-a-tertiary-academic-hospital-a-retrospective-11-year-study
#1
Lani Lieberman, Jordan Spradbrow, Amy Keir, Michael Dunn, Yulia Lin, Jeannie Callum
BACKGROUND: Intravenous immunoglobulin (IVIG) is used to treat a variety of diseases in the neonatal intensive care unit (NICU). Although audits have reported on the spectrum of IVIG use in adults, the indications and utilization in neonates has not been investigated. The objectives of this study were to describe the usage pattern of and indications for IVIG in a tertiary care NICU. STUDY DESIGN AND METHODS: A retrospective chart review was performed of all neonates who received IVIG in the NICU from January 2003 to December 2013...
July 26, 2016: Transfusion
https://www.readbyqxmd.com/read/26735259/a-novel-thyrotropin-releasing-hormone-receptor-missense-mutation-p81r-in-central-congenital-hypothyroidism
#2
O Koulouri, A K Nicholas, E Schoenmakers, J Mokrosinski, F Lane, T Cole, J Kirk, I S Farooqi, V K Chatterjee, M Gurnell, N Schoenmakers
CONTEXT: Isolated central congenital hypothyroidism (CCH) is rare and evades diagnosis on TSH-based congenital hypothyroidism (CH) screening programs in the United Kingdom. Accordingly, genetic ascertainment facilitates diagnosis and treatment of familial cases. Recognized causes include TSH β subunit (TSHB) and Ig superfamily member 1 (IGSF1) mutations, with only two previous reports of biallelic, highly disruptive mutations in the TRH receptor (TRHR) gene. CASE DESCRIPTION: A female infant presenting with prolonged neonatal jaundice was found to have isolated CCH, with TSH of 2...
March 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26334436/anti-d-administration-in-pregnancy-for-preventing-rhesus-alloimmunisation
#3
REVIEW
Rosemary D McBain, Caroline A Crowther, Philippa Middleton
BACKGROUND: During pregnancy, a Rhesus negative (Rh-negative) woman may develop antibodies when her fetus is Rhesus positive (Rh-positive). These antibodies may harm Rh-positive babies. OBJECTIVES: To assess the effects of antenatal anti-D immunoglobulin on the incidence of Rhesus D alloimmunisation when given to Rh-negative women without anti-D antibodies. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 May 2015) and reference lists of retrieved studies...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25899199/perforated-appendicitis-after-intravenous-immunoglobulin-therapy-in-a-term-neonate-with-haemolytic-jaundice
#4
Basak Yildiz Atikan, Ozge Altun Koroglu, Mehmet Yalaz, Orkan Ergun, Zafer Dokumcu, Basak Doganavsargil, Mete Akisu, Nilgun Kultursay
Neonatal appendicitis is a rare clinical condition that may cause high morbidity and mortality if diagnosis is delayed. There is usually an underlying disease; it can also be a localized form of necrotizing enterocolitis. Here, we present a term neonate who was treated with intravenous immunoglobulin because of severe isoimmune hemolytic jaundice. The patient developed abdominal symptoms within 10 hours of therapy, was diagnosed with acute perforated appendicitis and completely recovered after surgery.
April 2015: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/25125032/-efficacy-and-safety-of-intravenous-immunoglobulins-in-the-management-of-neonatal-hyperbilirubinemia-due-to-abo-incompatibility-a-meta-analysis
#5
REVIEW
A Cortey, M Elzaabi, T Waegemans, B Roch, Y Aujard
OBJECTIVES: ABO fetomaternal red blood cell incompatibility (ABO FMI) induces an immune hemolysis after fetal transfer of hemolyzing maternal anti-A or anti-B. ABO hemolytic disease (ABO HD) remains the most frequent cause of severe and early jaundice in newborns. High levels of unconjugated hyperbilirubinemia may induce acute and chronic neurological complications. Severe hyperbilirubinemia can be prevented by first-line phototherapy (PT) treatment, but exchange transfusion (ET) is required if treatment is not effective, even if ET is linked with high hemodynamic, infectious, gastrointestinal, and/or biological morbidity...
September 2014: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/24826985/clinically-significant-hemolytic-disease-of-the-newborn-secondary-to-passive-transfer-of-anti-d-from-maternal-rhig
#6
Daniel N Cohen, Mary S Johnson, Wayne H Liang, Heather L McDaniel, Pampee P Young
BACKGROUND: RhIG is used worldwide to reduce the incidence of alloimmunization to D during pregnancy. We report a case of clinically significant neonatal hemolysis mediated by maternally administered RhIG. CASE REPORT: A 25-year-old, O-, primigravid mother with a negative antenatal antibody screen delivered a 6-lb 4-oz, blood group A, D+ baby girl at 36.5 weeks' gestation. Prenatal care included a dose of intramuscular RhIG at 28 weeks' gestation. At delivery, the newborn was markedly jaundiced with a total bilirubin of 6...
November 2014: Transfusion
https://www.readbyqxmd.com/read/24810454/anti-m-antibodies-as-a-cause-of-intrauterine-fetal-death-and-neonatal-hyperbilirubinaemia
#7
Deepak Sharma, Anuradha Murki, Srinivas Murki, Tejo Pratap
A preterm male infant (35 weeks), appropriate for gestational age with birth weight of 2.20 kg was born to a 28-year G2 P0 mother. The mother's blood group was A positive and the father's was B positive. Her first pregnancy was an intrauterine fetal death due to immune hydrops. The mother's blood was positive for indirect Coomb's test with 1:32 dilution and anti-M antibodies. This pregnancy was induced at 35 weeks of gestation. Investigations from the cord blood revealed A positive blood group, positive direct Coomb's test, haematocrit of 41...
2014: BMJ Case Reports
https://www.readbyqxmd.com/read/24382531/neonatal-hyperbilirubinemia-due-to-abo-incompatibility-does-blood-group-matter
#8
Sinem Akgül, Ayşe Korkmaz, Sule Yiğit, Murat Yurdakök
Newborn infants with maternal-fetal ABO incompatibility are at a greater risk for developing subsequent significant hyperbilirubinemia, and therefore, prediction of probable risk factors, such as the degree of hemolysis, gains importance. In this study, we aimed to evaluate the effect of fetal-neonatal blood group on the severity of hemolysis and jaundice due to maternal-fetal ABO incompatibility. In a retrospective analysis of 166 cases with ABO hemolytic disease of the newborn, risk factors for the severity of jaundice were compared in infants with blood group A or B...
September 2013: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/24265360/high-rates-of-congenital-cytomegalovirus-infection-linked-with-maternal-hiv-infection-among-neonatal-admissions-at-a-large-referral-center-in-sub-saharan-africa
#9
Nyaxewo Mwaanza, Lophina Chilukutu, John Tembo, Mwila Kabwe, Kunda Musonda, Monica Kapasa, Chishala Chabala, Sylvester Sinyangwe, Peter Mwaba, Alimuddin Zumla, Matthew Bates
BACKGROUND:  Congenital cytomegalovirus (CMV) infection is the major infectious cause of birth defects and hearing loss globally. There is a growing recognition of the potential clinical impact of congenital CMV infections in high-seroprevalence settings. METHODS:  A cross-sectional study of neonatal admissions at a large referral center in sub-Saharan Africa to determine the prevalence of both symptomatic and asymptomatic congenital CMV infection was performed...
March 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/23543581/anti-d-administration-after-spontaneous-miscarriage-for-preventing-rhesus-alloimmunisation
#10
REVIEW
Laxminarayan Karanth, Sharifah Halimah Jaafar, Sachchithanantham Kanagasabai, N S Nair, Ankur Barua
BACKGROUND: During pregnancy, a Rhesus-negative (Rh-negative) woman may develop antibodies if her fetus is Rh-positive, which can cause fetal morbidity or mortality in following pregnancies, if untreated. OBJECTIVES: To assess the effects of administering anti-D immunoglobulin (Ig) after spontaneous miscarriage in a Rh-negative woman, with no anti-D antibodies. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2012)...
2013: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/23450526/anti-d-administration-in-pregnancy-for-preventing-rhesus-alloimmunisation
#11
REVIEW
Caroline A Crowther, Philippa Middleton, Rosemary D McBain
BACKGROUND: During pregnancy, a Rhesus negative (Rh-negative) woman may develop antibodies when her fetus is Rhesus positive (Rh-positive). These antibodies may harm Rh-positive babies. OBJECTIVES: To assess the effects of antenatal anti-D immunoglobulin on the incidence of Rhesus D alloimmunisation when given to Rh-negative women without anti-D antibodies. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September 2012)...
2013: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/21926893/hyperbilirubinemia-current-guidelines-and-emerging-therapies
#12
REVIEW
Hamilton P Schwartz, Beth E Haberman, Richard M Ruddy
It is estimated that about two thirds of newborns will appear clinically jaundiced during their first weeks of life. As newborns and their mothers spend fewer days in the hospital after birth, the number of infants readmitted yearly in the United States for neonatal jaundice over the last 10 years has increased by 160%. A portion of these infants present to the emergency department, requiring a careful history and physical examination assessing them for the risk factors associated with pathologic bilirubin levels...
September 2011: Pediatric Emergency Care
https://www.readbyqxmd.com/read/21920055/neonatal-jaundice
#13
REVIEW
Paul Woodgate, Luke Anthony Jardine
INTRODUCTION: About 50% of term and 80% of preterm babies develop jaundice, which usually appears 2 to 4 days after birth, and resolves spontaneously after 1 to 2 weeks. Jaundice is caused by bilirubin deposition in the skin. Most jaundice in newborn infants is a result of increased red cell breakdown and decreased bilirubin excretion. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for unconjugated hyperbilirubinaemia in term and preterm infants? We searched Medline, Embase, The Cochrane Library, and other important databases up to February 2010 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review)...
September 15, 2011: Clinical Evidence
https://www.readbyqxmd.com/read/21617887/single-versus-multiple-dose-intravenous-immunoglobulin-in-combination-with-led-phototherapy-in-the-treatment-of-abo-hemolytic-disease-in-neonates
#14
Gamze Demirel, Melek Akar, Istemi Han Celik, Omer Erdeve, Nurdan Uras, Serife Suna Oguz, Ugur Dilmen
Intravenous immunoglobulin (IVIG) has been found to decrease hemolysis in neonatal jaundice due to blood group incompatibility, but a consensus on its usage has not been reached. We conducted a study to compare single versus multiple dose of IVIG in combination with light emitting diode (LED) phototherapy in patients with neonatal jaundice secondary to ABO blood incompatibility, and compared the efficacy of these treatments with that in a group of patients who received LED phototherapy solely. Thirty-nine term neonates with ABO blood group incompatibility were enrolled in the study...
June 2011: International Journal of Hematology
https://www.readbyqxmd.com/read/20973864/has-anti-d-prophylaxis-increased-the-rate-of-positive-direct-antiglobulin-test-results-and-can-the-direct-antiglobulin-test-predict-need-for-phototherapy-in-rh-abo-incompatibility
#15
Alexander Dillon, Tejasvi Chaudhari, Phillip Crispin, Bruce Shadbolt, Alison Kent
AIM: To determine the impact of Rhesus (Rh) D prophylaxis on positive direct antiglobulin test (DAT) results and ability of a DAT grade to predict an infant's need for phototherapy. METHODS: Laboratory and infant medical records were reviewed for DAT status, DAT grade, interventions for hyperbilirubinemia including phototherapy, blood transfusion, exchange transfusion and intravenous immunoglobulin. Two epochs of DAT results were reviewed, the first in the era prior to Rh D prophylaxis, the second after introduction of standardised Rh D prophylaxis for Rh negative women...
January 2011: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/20628321/isolated-early-onset-anemia-after-rh-isoimmunization-a-unique-presentation-in-3-neonates
#16
Deepak Louis, Sapna Oberoi, Venkataseshan Sundaram, Amita Trehan
Rh isoimmunization manifesting as isolated early onset neonatal anemia has not been reported. We describe the presentation of 3 infants who manifested with isolated early severe anemia. All the infants presented early (3 to 7 d of age) with severe pallor. None had clinically significant jaundice. Evidence for hemolysis was present in all and their direct antiglobulin test was positive. To reduce the hemolysis, immunoglobulin was administered after which their hemoglobin improved. This report highlights the possibility of early onset anemia without significant jaundice as the sole manifestation of Rh isoimmunization and the possible beneficial role of immunoglobulin in them...
August 2010: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/20564941/-an-alternative-method-of-treatment-for-the-icteric-anemic-form-of-neonatal-iso-immunization-to-rhesus-factor
#17
S A Perepelitsa, N A Kashina, N L Sidorova
Neonatal iso-immunization to rhesus factor is a rather well studied pathology. Negative rhesus factor in a pregnant women is a ground to determine anti-D-antibody titers during pregnancy, which allows one to define the tactics of pregnancy management and neonatal treatment just after birth.
January 2010: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/20412407/survey-of-management-of-neonatal-haemolytic-jaundice-in-australasia
#18
Atul Malhotra, Elizabeth Carse
BACKGROUND: Haemolytic jaundice is an important entity in neonatal clinical practice. Because of the decrease in rhesus isoimmunisation since the advent of anti-D immunoglobulin and improved antenatal management strategies, its management in the neonatal period has become less intensive and exchange transfusions rarely performed. AIM: We planned to review the practice of Australasian perinatal units in light of recent advances and recommendations. METHODS: An electronic survey was sent to the directors of all 25 tertiary-level perinatal units across Australasia...
May 2010: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/20021783/-hemolytic-disease-of-neonates-due-to-anti-m-report-of-one-case-and-review-of-reports-of-21-cases
#19
Xiang-yu Gao, Huan Huang, Li-da Li
OBJECTIVE: To analyze and summarize clinical manifestation of hemolytic disease of the newborn (HDN) due to anti-M. METHODS: Data of one case of HDN due to anti-M and the reports of 21 cases seen in the past 20 years at the home country were reviewed and analyzed. RESULTS: There was an increasing number of reports of cases with HDN due to anti-M. Among the 22 cases, four were the first fetus. Of 18 infants, ten were male, and eight were female...
September 2009: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/19998894/icteric-skin-sclera-and-mucous-membranes
#20
Jillian Roberts, Mark A Toney
No abstract text is available yet for this article.
September 2007: Advance for Nurse Practitioners
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