Ruwen Böhm, Henrike Bruckmueller, Stefan Oswald, Matthias Hübenthal, Meike Kaehler, Lena Ehmke, Jan Höcker, Werner Siegmund, Andre Franke, Ingolf Cascorbi
Although great progress has been made in the fine-tuning of diplotypes, there is still a need to further improve the predictability of individual phenotypes of pharmacogenetically relevant enzymes. The aim of this study was to analyze the additional contribution of sex and variants identified by exome chip analysis to the metabolic ratio of five probe drugs. A cocktail study applying dextromethorphan, losartan, omeprazole, midazolam, and caffeine was conducted on 200 healthy volunteers. CYP2D6, 2C9, 2C19, 3A4/5, and 1A2 genotypes were analyzed and correlated with metabolic ratios...
April 18, 2024: Clinical Pharmacology and Therapeutics