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https://www.readbyqxmd.com/read/27932229/regorafenib-for-patients-with-hepatocellular-carcinoma-who-progressed-on-sorafenib-treatment-resorce-a-randomised-double-blind-placebo-controlled-phase-3-trial
#1
Jordi Bruix, Shukui Qin, Philippe Merle, Alessandro Granito, Yi-Hsiang Huang, György Bodoky, Marc Pracht, Osamu Yokosuka, Olivier Rosmorduc, Valeriy Breder, René Gerolami, Gianluca Masi, Paul J Ross, Tianqiang Song, Jean-Pierre Bronowicki, Isabelle Ollivier-Hourmand, Masatoshi Kudo, Ann-Lii Cheng, Josep M Llovet, Richard S Finn, Marie-Aude LeBerre, Annette Baumhauer, Gerold Meinhardt, Guohong Han
BACKGROUND: There are no systemic treatments for patients with hepatocellular carcinoma (HCC) whose disease progresses during sorafenib treatment. We aimed to assess the efficacy and safety of regorafenib in patients with HCC who have progressed during sorafenib treatment. METHODS: In this randomised, double-blind, parallel-group, phase 3 trial done at 152 sites in 21 countries, adults with HCC who tolerated sorafenib (≥400 mg/day for ≥20 of last 28 days of treatment), progressed on sorafenib, and had Child-Pugh A liver function were enrolled...
December 5, 2016: Lancet
https://www.readbyqxmd.com/read/27928745/perceived-emotion-genuineness-normative-ratings-for-popular-facial-expression-stimuli-and-the-development-of-perceived-as-genuine-and-perceived-as-fake-sets
#2
Amy Dawel, Luke Wright, Jessica Irons, Rachael Dumbleton, Romina Palermo, Richard O'Kearney, Elinor McKone
In everyday social interactions, people's facial expressions sometimes reflect genuine emotion (e.g., anger in response to a misbehaving child) and sometimes do not (e.g., smiling for a school photo). There is increasing theoretical interest in this distinction, but little is known about perceived emotion genuineness for existing facial expression databases. We present a new method for rating perceived genuineness using a neutral-midpoint scale (-7 = completely fake; 0 = don't know; +7 = completely genuine) that, unlike previous methods, provides data on both relative and absolute perceptions...
December 7, 2016: Behavior Research Methods
https://www.readbyqxmd.com/read/27903795/how-can-professionals-carry-out-recognition-towards-children-of-parents-with-alcohol-problems-a-qualitative-interview-study
#3
Anne Werner, Kirsti Malterud
AIM: The aim of this study was to explore informal adult support experienced by children with parental alcohol problems to understand how professionals can show recognition in a similar way. METHODS: We conducted a qualitative interview study with retrospective accounts from nine adults growing up with problem-drinking parents. Data were analysed with systematic text condensation. Goffman's concept "frame" offered a lens to study how supportive situations were defined and to understand opportunities and limitations for translation of recognition acts and attitudes to professional contexts...
November 30, 2016: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/27900946/childhood-psoriasis
#4
Emmanuel Mahé
Psoriasis is a common chronic inflammatory skin disease. Recently, few data have been published on epidemiology, comorbidity, or therapy in children with psoriasis. Psoriasis affects up to 2% of children in Europe, even during the first months of life. The link between psoriasis and metabolic comorbidities has been highlighted, notably in relation to excessive weight and obesity. The clinical picture of psoriasis in childhood resembles adult disease, however, some clinical features are noteworthy: neonatal diaper rash is relatively specific, face involvement and guttate psoriasis are more common, plaques are often smaller, and scales are finer and softer than in adults...
November 29, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27871720/-guidelines-for-the-prescription-of-mood-stabilizers-for-adolescents-a-literature-review
#5
G Munch, N Godart
INTRODUCTION: Adolescence is a unique phase of the human developmental process. In adolescents, psychotropic medications may have different efficacy and tolerance profiles compared to those at other stages of the lifespan. Mood stabilizers are a complex pharmacological category including lithium, some anticonvulsants, and some second generation antipsychotics. Focusing on this class of pharmacological agents, we aim to answer the following questions: in which indications and according to which modalities should mood stabilizers be prescribed during adolescence? METHODS: Information was sought from the websites of the French Haute Autorité de santé (HAS) and Agence nationale de sécurité du médicament et des produits de santé (ANSM), the American Food and Drug Administration (FDA) and the British National Institute for Health and Clinical Excellence (NICE)...
November 18, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27861588/endogenous-testosterone-and-exogenous-oxytocin-modulate-attentional-processing-of-infant-faces
#6
Sarah K C Holtfrerich, Katharina A Schwarz, Christian Sprenger, Luise Reimers, Esther K Diekhof
Evidence indicates that hormones modulate the intensity of maternal care. Oxytocin is known for its positive influence on maternal behavior and its important role for childbirth. In contrast, testosterone promotes egocentric choices and reduces empathy. Further, testosterone decreases during parenthood which could be an adaptation to increased parental investment. The present study investigated the interaction between testosterone and oxytocin in attentional control and their influence on attention to baby schema in women...
2016: PloS One
https://www.readbyqxmd.com/read/27855347/constructing-embodied-identity-in-a-new-ageing-population-a-qualitative-study-of-the-pioneer-cohort-of-childhood-liver-transplant-recipients-in-the-uk
#7
Karen Lowton, Chris Hiley, Paul Higgs
Medical innovations have created a future of survivorship for many groups of people with a variety of conditions that were previously untreatable or untreated. This has led not only to an expansion of medical activity in a whole variety of new areas but also to the emergence of new groups of individuals defined or defining themselves through their experiences, diagnosis and treatment. Through analysis of in-depth interviews with 27 of the now-adult survivors of the pioneer cohort of children receiving liver transplants in Britain in the early 1980s and 1990s, this paper presents how this group not only illustrate the capacities of modern medicine and healthcare to transform the survival prospects of a more diversified population, but also create new narratives of embodied identity...
November 11, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27846732/complete-mental-health-in-adult-siblings-of-those-with-a-chronic-illness-or-disability
#8
Madeleine Hallion, Amanda Taylor, Rachel Roberts
INTRODUCTION: Sibling relationships have lifelong significance and childhood chronic illness and disability can have considerable impacts on healthy siblings, influencing development into adulthood. Research has not yet assessed well-being in this population using measures of both mental health and mental illness. Thus, this study assessed well-being in a comprehensive manner using the complete mental health (CMH) model. METHOD: Participants (N = 144) included both adult siblings of those with chronic illness or disability and adults with healthy siblings...
November 16, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27796690/adhd-and-depression-symptoms-in-parent-couples-predict-response-to-child-adhd-and-odd-behavior
#9
Brian T Wymbs, Anne E Dawson, Theresa E Egan, Gina M Sacchetti, Sean T Tams, Frances A Wymbs
Parents of children with attention-deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) often have elevated ADHD and depressive symptoms, both of which increase the risk of ineffective parenting and interparental discord. However, little is known about whether child ADHD/ODD behavior and parent ADHD or depressive symptoms uniquely or synergistically predict the quality of parenting and interparental communication during triadic (mother-father-child) interactions. Ninety parent couples, including 51 who have children diagnosed with ADHD, were randomly assigned to interact with a 9-12 year-old confederate child (84 % male) exhibiting either ADHD/ODD-like behavior or typical behavior...
October 28, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/27780491/association-of-adverse-childhood-experiences-with-lifetime-mental-and-substance-use-disorders-among-men-and-women-aged-50-years
#10
Namkee G Choi, Diana M DiNitto, C Nathan Marti, Bryan Y Choi
BACKGROUND: Given growing numbers of older adults with mental and substance use disorders (MSUDs), this study examined the association between ten types of adverse childhood experiences (ACEs) and lifetime MSUDs among those aged 50+. METHODS: Data (N = 14,738 for the 50+ age group) came from the 2012 to 2013 National Epidemiologic Survey on Alcohol and Related Conditions. Using multivariable binary logistic regression analyses, we examined relationships between ten ACEs and six lifetime MSUDs (major depressive disorder (MDD) and anxiety, post-traumatic stress, alcohol use, drug use, and nicotine use disorders)...
October 26, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27780110/latent-classes-of-childhood-poly-victimization-and-associations-with-suicidal-behavior-among-adult-trauma-victims-moderating-role-of-anger
#11
Ruby Charak, Brianna M Byllesby, Michelle E Roley, Meredith A Claycomb, Tory A Durham, Jana Ross, Cherie Armour, Jon D Elhai
The aims of the present study were first to identify discrete patterns of childhood victimization experiences including crime, child maltreatment, peer/sibling victimization, sexual violence, and witnessing violence among adult trauma victims using latent class analysis; second, to examine the association between class-membership and suicidal behavior, and third to investigate the differential role of dispositional anger on the association between class-membership and suicidal behavior. We hypothesized that those classes with accumulating exposure to different types of childhood victimization (e...
December 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27771538/successful-communication-does-not-drive-language-development-evidence-from-adult-homesign
#12
Emily M Carrigan, Marie Coppola
Constructivist accounts of language acquisition maintain that the language learner aims to match a target provided by mature users. Communicative problem solving in the context of social interaction and matching a linguistic target or model are presented as primary mechanisms driving the language development process. However, research on the development of homesign gesture systems by deaf individuals who have no access to a linguistic model suggests that aspects of language can develop even when typical input is unavailable...
October 20, 2016: Cognition
https://www.readbyqxmd.com/read/27768174/a-modeling-study-of-the-effects-of-vocal-tract-movement-duration-and-magnitude-on-the-f2-trajectory-in-cv-words
#13
Kimberly D Neely, Kate Bunton, Brad H Story
Purpose: This study used a computational vocal tract model to investigate the relationship of diphthong duration and vocal tract movement magnitude to measures of the F2 trajectory in CV words. Method: Three words (bough, boy, and buy) were simulated on the basis of an adult female vocal tract model, in which the model parameters were estimated from audio recordings of a female talker. Model parameters were then modified to generate 35 simulations of each word corresponding to 7 different durations and 5 movement magnitude settings...
October 20, 2016: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/27763988/child-abuse-and-neglect-and-subclinical-cardiovascular-disease-among-midlife-women
#14
Rebecca C Thurston, Yuefang Chang, Emma Barinas-Mitchell, Roland von Känel, J Richard Jennings, Nanette Santoro, Doug P Landsittel, Karen A Matthews
OBJECTIVES: A childhood history of abuse or neglect may be associated with elevated adult cardiovascular disease (CVD) risk. No studies have examined associations between child abuse/neglect and subclinical CVD using a validated measure of abuse and neglect. We hypothesized that midlife women with a history of childhood abuse or neglect would have increased subclinical CVD beyond standard CVD risk factors. We tested moderation of associations by sleep, hot flashes, and race/ethnicity...
October 19, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27763985/early-life-experiences-and-telomere-length-in-adult-rhesus-monkeys-an-exploratory-study
#15
Lisa M Schneper, Jeanne Brooks-Gunn, Daniel A Notterman, Stephen J Suomi
OBJECTIVE: Child-rearing environments have been associated with morbidity in adult rhesus monkeys. We examine whether such links are also seen with leukocyte telomere length. METHODS: To determine telomere length in leukocytes, blood was collected from 11 adult female monkeys aged 7 to 10 years who had been exposed to different rearing environments between birth and 7 months. Four had been reared with their mothers in typical social groups composed of other female monkeys, their offspring, and 1 to 2 adult male monkeys...
November 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27759166/reflective-practice-in-organizational-learning-cultural-self-understanding-and-community-self-strengthening
#16
Joshua Sparrow
The infant mental health field can amplify its effects when it extends its purview beyond the dyad to the larger contexts in which infants and adult caregivers interact and develop over time. Within health, mental health, education, and other human service organizations, the quality of relationships is a critical variable in the individual-level outcomes that such organizations seek. The goals of this work and the means for accomplishing them are highly dependent on human qualities and interactions that are shaped by organizational processes...
November 2016: Infant Mental Health Journal
https://www.readbyqxmd.com/read/27742391/-early-restrictive-feeding-disorders-quantitative-assessment-of-parent-infant-feeding-interactions
#17
A Bion, T Cascales, S Dubedout, N Bodeau, J P Olives, J P Raynaud
INTRODUCTION: Interest in the study of early feeding disorders (FD) has steadily increased during recent decades. During this period, research described the importance of the transactional relationships and the complex interplay between caregiver and child over time. On the basis of the previous studies, our study tried to explore the associations between the characteristics of the parents and the temperamental characteristics of the infants with early FD. GOALS: A first aim of the present study was to show if parental perception of child temperament (including ability for arousal self-regulation) and parental characteristics (emotional and eating attitudes) are associated with early FD...
October 11, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27734758/own-age-biases-in-adult-s-and-children-s-joint-attention-biased-face-prioritisation-but-not-gaze-following
#18
Susannah Freebody, Gustav Kuhn
Joint attention forms an essential part of language development and human interaction. Several previous studies have reported own-age biases in younger and older adults in gaze following. We investigated own-age biases in social attentional processes between adults and children by focusing on two aspects of the joint attention process, namely the extent to which people attend towards an individual's face, and the extent to which they fixate objects that are looked at by this person (i.e. gaze following). Participants viewed images that always contained a child and an adult who either looked towards each other or they each looked at an object located to their side...
October 13, 2016: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/27720744/the-association-of-serotonin-receptor-3a-methylation-with-maternal-violence-exposure-neural-activity-and-child-aggression
#19
Daniel S Schechter, Dominik A Moser, Virginie C Pointet, Tatjana Aue, Ludwig Stenz, Ariane Paoloni-Giacobino, Wafae Adouan, Aurélia Manini, Francesca Suardi, Marylene Vital, Ana Sancho Rossignol, Maria I Cordero, Molly Rothenberg, François Ansermet, Sandra Rusconi Serpa, Alexandre G Dayer
BACKGROUND: Methylation of the serotonin 3A receptor gene (HTR3A) has been linked to child maltreatment and adult psychopathology. The present study examined whether HTR3A methylation might be associated with mothers' lifetime exposure to interpersonal violence (IPV), IPV-related psychopathology, child disturbance of attachment, and maternal neural activity. METHODS: Number of maternal lifetime IPV exposures and measures of maternal psychopathology including posttraumatic stress disorder (PTSD), major depression and aggressive behavior (AgB), and a measure of child attachment disturbance known as "secure base distortion" (SBD) were assessed in a sample of 35 mothers and children aged 12-42 months...
October 5, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27711150/the-association-of-current-violence-from-adult-family-members-with-adolescent-bullying-involvement-and-suicidal-feelings
#20
Shinya Fujikawa, Shuntaro Ando, Shinji Shimodera, Shinsuke Koike, Satoshi Usami, Rie Toriyama, Sho Kanata, Tsukasa Sasaki, Kiyoto Kasai, Yuji Okazaki, Atsushi Nishida
Although several studies have reported that child physical abuse increased the risk for bullying involvement, the effect of current violence from adult family members (CVA) on bullying involvement and suicidal feelings among adolescents has not been sufficiently examined. This study investigated the association of CVA with adolescent bullying involvement and the interaction effect of CVA and bullying involvement on suicidal feelings. This cross-sectional study used data from a school-based survey with a general population of adolescents (grades 7 to 12)...
2016: PloS One
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