keyword
https://read.qxmd.com/read/38529718/a-case-of-pregnancy-with-severe-polyhydramnios-related-to-long-term-use-of-lithium
#1
JOURNAL ARTICLE
Aldo Stoppa, Ester Roda, Lluïsa Garcia-Esteve, Alba Roca-Lecumberri
OBJECTIVES: Severe polyhydramnios during pregnancy may be associated with long-term lithium use and presents considerable challenges. This complication, which has been linked to induced nephrogenic diabetes insipidus (NDI), underscores the necessity for cautious management of pregnant women with bipolar disorder. This case report aims to elucidate the relationship between long-term lithium use, pregnancy, and the development of severe polyhydramnios, emphasizing the importance of diagnosing NDI in order to prevent obstetric and neonatal complications...
March 26, 2024: Bipolar Disorders
https://read.qxmd.com/read/38450903/congenital-nephrogenic-diabetes-insipidus-treated-with-acetazolamide
#2
Wesley Du Plessis, Mogamat-Yazied Chothia
Congenital nephrogenic diabetes insipidus (CNDI) is a rare disorder. The condition is characterised by an inability of distal nephron segments to respond to normal or raised concentrations of serum antidiuretic hormone. In this report, we describe the case of a 13-year-old male known with CNDI who experienced a pedestrian vehicle accident leading to coma following a head injury. Intra-operatively, severe hypernatraemia and polyuria were observed. Following an inadequate response to conventional therapy, acetazolamide was prescribed resulting in an immediate response to therapy...
March 7, 2024: Nephrology
https://read.qxmd.com/read/38374833/chronic-lithium-intoxication-a-challenging-diagnosis
#3
Sofia Ferreira, Sara Santos, Sérgio Gomes Ferreira, Luís Fernandes, Penélope Almeida
Lithium has been used in clinical practice since the 1970s. This medication is commonly used to treat and prevent bipolar disorder, but it has a narrow therapeutic index, making toxicity a frequent occurrence. Chronic lithium intoxication can arise due to progressive accumulation, particularly in contexts of dehydration. The effects of chronic lithium intoxication on the nervous, renal, and cardiac systems, as well as on the thyroid and parathyroid glands, are well documented in the literature. The authors present the case of a 66-year-old woman with schizoaffective psychosis and chronic kidney disease, admitted due to altered mental status and dysarthria...
January 2024: Curēus
https://read.qxmd.com/read/38361653/nephrogenic-diabetes-insipidus-in-a-geriatric-patient-affected-by-sars-cov-2-complexity-of-a-diagnosis-complexity-of-a-virus
#4
Maria Ada Corich, Michele Niero, Lucia Corich, Elisabetta Ferretti, Paolo De Colle, Stella Bernardi, Giuliano Ceschia, Gianfranco Sanson, Michela Zanetti
BACKGROUND: Coronavirus disease 2019 (COVID-19) has an important impact on the kidney through direct and indirect damage mechanisms. Most previous studies have highlighted lesions caused by this virus in the early segments of the nephron. However, due to the antigenic characteristics of the virus, with almost ubiquitous receptors, and the molecular release it triggers, the distal segments of the nephron could also be affected. METHODS: A 71 year-old-man with respiratory failure while suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia presented with typical symptoms of diabetes insipidus after ~20 days of hospitalization...
2024: Access microbiology
https://read.qxmd.com/read/38329376/lithium-associated-nephrogenic-diabetes-insipidus-or-catatonic-stereotypical-drinking-a-case-report-and-literature-review
#5
REVIEW
Yassir Mahgoub, Irem Yapar, Delaney Harbold
No abstract text is available yet for this article.
March 2024: Journal of Clinical Psychopharmacology
https://read.qxmd.com/read/38316255/diabetes-insipidus-vasopressin-deficiency%C3%A2
#6
REVIEW
Fanny Chasseloup, Antoine Tabarin, Philippe Chanson
Diabetes insipidus is a disorder characterized by hypo-osmotic polyuria secondary to abnormal synthesis, regulation, or renal action of antidiuretic hormone. Recently, an expert group, with the support of patient associations, proposed that diabetes insipidus be renamed to avoid confusion with diabetes mellitus. The most common form of diabetes insipidus is secondary to a dysfunction in the neurohypophysis (central diabetes insipidus) and would be therefore termed 'vasopressin deficiency'. The rarer form, which is linked to renal vasopressin resistance (nephrogenic diabetes insipidus), would then be named 'vasopressin resistance'...
February 3, 2024: Annales D'endocrinologie
https://read.qxmd.com/read/38291597/the-diagnostic-performance-of-copeptin-in-clinical-practice-a-prospective-study
#7
JOURNAL ARTICLE
Penelope Trimpou, Ioannis Bounias, Olof Ehn, Ola Hammarsten, Oskar Ragnarsson
OBJECTIVE: Plasma copeptin is a relatively new biomarker for evaluation of arginine vasopressin (AVP) secretion. The aim of this study was to test the diagnostic performance of copeptin in patients with polyuria-polydipsia syndrome. DESIGN, PATIENTS AND MEASUREMENTS: This was a prospective study where 88 patients with polyuria-polydipsia syndrome were evaluated with a water deprivation test (WDT). Weight, urine osmolality, urine specific gravity, and plasma copeptin were collected at baseline, after 8 h, and at termination of the WDT when one of the following had been reached: (i) >3% weight reduction, (ii) urine specific gravity >1...
January 30, 2024: Clinical Endocrinology
https://read.qxmd.com/read/38254165/targeted-long-read-sequencing-identified-a-causal-structural-variant-in-x-linked-nephrogenic-diabetes-insipidus
#8
JOURNAL ARTICLE
Lukáš Strych, Monika Černá, Markéta Hejnalová, Tomáš Zavoral, Pavla Komrsková, Jitka Tejcová, Ibrahim Bitar, Eva Sládková, Josef Sýkora, Ivan Šubrt
BACKGROUND: X-linked nephrogenic diabetes insipidus (NDI) is a rare genetic renal disease caused by pathogenic variants in the AVPR2 gene. Single nucleotide variants and small insertions/deletions in AVPR2 are reliably detected by routine clinical sequencing. Nevertheless, structural variants involving AVPR2 are challenging to identify accurately by conventional genetic testing. Here, we report a novel deletion of AVPR2 in a Czech family identified for the first time by targeted long-read sequencing (T-LRS)...
January 22, 2024: BMC Medical Genomics
https://read.qxmd.com/read/38059298/urine-concentration-impairment-in-sickle-cell-anemia-genuine-nephrogenic-diabetes-insipidus-or-osmotic-diuresis
#9
JOURNAL ARTICLE
Quentin de Berny, Camille Saint-Jacques, Aline Santin, Sarah Mattioni, Olivier Steichen, Rémi Chieze, Vincent Frochot, Emmanuel Letavernier, Francois Lionnet, Jean-Philippe Haymann
The urine concentration impairment responsible for hyposthenuria in sickle cell nephropathy is currently thought to be a consequence of renal medulla lesions, which lead to nephrogenic diabetes insipidus. The objective of the present study was to investigate the mechanism of hyposthenuria in patients with sickle cell anemia. We performed an observational study of patients with homozygous SS sickle cell anemia and data available on the fasting plasma antidiuretic hormone (ADH) concentration. A total of 55 patients were analyzed...
December 7, 2023: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38031874/ifosfamide-induced-nephrotoxicity-in-oncological-patients
#10
JOURNAL ARTICLE
Juan Eduardo Quiroz-Aldave, María Del Carmen Durand-Vasquez, Freddy Shanner Chávez-Vásquez, Alexandra Noelia Rodríguez-Angulo, Sonia Elizabeth Gonzáles-Saldaña, Carlos César Alcalde-Loyola, Julia Cristina Coronado-Arroyo, Francisca Elena Zavaleta-Gutiérrez, Luis Alberto Concepción-Urteaga, Juan Carlos Haro-Varas, Marcio José Concepción-Zavaleta
INTRODUCTION: Ifosfamide is an alkylating chemotherapeutic agent used in the treatment of various neoplasms. Its main adverse effects include renal damage. AREAS COVERED: A comprehensive review was conducted, including 100 articles from the Scielo, Scopus, and EMBASE databases. Ifosfamide-induced nephrotoxicity is attributed to its toxic metabolites, such as acrolein and chloroacetaldehyde, which cause mitochondrial damage and oxidative stress in renal tubular cells...
November 30, 2023: Expert Review of Anticancer Therapy
https://read.qxmd.com/read/37968178/tubular-diseases-and-stones-seen-from-pediatric-and-adult-nephrology-perspectives
#11
REVIEW
Johannes Münch, Paul R Goodyer, Carsten A Wagner
The tubular system of the kidneys is a complex series of morphologic and functional units orchestrating the content of tubular fluid as it flows along the nephron and collecting ducts. Renal tubules maintain body water, regulate electrolytes and acid-base balance, reabsorb precious organic solutes, and eliminate specific metabolites, toxins, and drugs. In addition, decisive mechanisms to adjust blood pressure are governed by the renal tubules. Genetic as well as acquired disorders of these tubular functions may cause serious diseases that manifest both in childhood and adulthood...
July 2023: Seminars in Nephrology
https://read.qxmd.com/read/37930141/exploring-the-diversity-of-avpr2-in-primates-and-its-evolutionary-implications
#12
JOURNAL ARTICLE
Bibiana Sampaio de Oliveira Fam, Pedro Vargas-Pinilla, Pâmela Paré, Luane Landau, Lucas H Viscardi, Alcides Pissinatti, Tiago Falótico, Renan Maestri, Maria Cátira Bortolini
The current study focuses on the investigation of AVPR2 (VTR2C) protein-coupled receptor variants specific to different primate taxa. AVPR2 is activated by the neurohormone AVP, which modulates physiological processes, including water homeostasis. Our findings reveal positive selection at three AVPR2 sites at positions 190, 250, and 346. Variation at position 250 is associated with human Congenital Nephrogenic Diabetes Insipidus (cNDI), a condition characterized by excessive water loss. Other 13 functional sites with potential adaptive relevance include positions 185, 202, 204, and 252 associated with cNDI...
2023: Genetics and Molecular Biology
https://read.qxmd.com/read/37909842/first-report-on-female-monozygotic-twins-discordant-for-congenital-nephrogenic-diabetes-insipidus
#13
JOURNAL ARTICLE
Xiang Chen, Libing Yun, Yang Long, Yuxia Sun, Tao Chen
Ninety percent of congenital nephrogenic diabetes insipidus (NDI) are X-linked inherited and are caused by mutations in the vasopressin type 2 receptor gene (AVPR2). Most affected individuals are males. Only sporadic female cases have been reported. Here, we first reported a female monozygotic twin with discordant phenotypes for NDI carrying a missense variant c.845T>C (p.Leu282Pro) in exon 4 of AVPR2. Intracellular cAMP concentrations in COS7 cells transfected with AVPR2-L282P were significantly decreased by about 60% compared with those in wild-type AVPR2 plasmid transfected cells, suggesting this variation was pathogenic...
November 1, 2023: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/37900924/three-pediatric-patients-with-congenital-nephrogenic-diabetes-insipidus-due-to-avpr2-nonsense-mutations-and-different-clinical-manifestations-a-case-report
#14
Hijiri Watanabe, Hiroshi Tamura, Keishiro Furuie, Shohei Kuraoka, Hitoshi Nakazato
Congenital nephrogenic diabetes insipidus (CNDI), a rare hereditary disorder, is characterized by the inability of the kidneys to concentrate urine in response to the antidiuretic hormone arginine vasopressin (AVP); as a result, large volumes of unconcentrated urine are excreted. In addition to the clinical manifestations of CNDI, such as dehydration and electrolyte disturbances (hypernatremia and hyperchloremia), developmental delay can result without prompt treatment. In approximately 90% of cases, CNDI is an X-linked disease caused by mutations in the arginine vasopressin receptor 2 ( AVPR2 ) gene...
2023: Case Reports in Nephrology and Dialysis
https://read.qxmd.com/read/37897631/a-case-of-ifosfamide-induced-acute-kidney-injury-fanconi-syndrome-and-nephrogenic-diabetes-insipidus
#15
JOURNAL ARTICLE
Summer Hoang, Thejeswi Pujar, Ezequiel Bellorin-Font, John C Edwards, Kana N Miyata
Ifosfamide, a cytotoxic antineoplastic drug, can induce rare complications of Fanconi syndrome and nephrogenic diabetes insipidus (DI). Ifosfamide-induced Fanconi syndrome tends to occur in patients with certain risk factors including young age, high cumulative ifosfamide dose, and coadministration of cisplatin. Nephrogenic DI causes polyuria from impaired urinary concentrating ability due to resistance to arginine vasopressin (AVP) at the collecting duct. These complications are serious and potentially fatal...
October 28, 2023: CEN Case Reports
https://read.qxmd.com/read/37847389/-nephrogenic-diabetes-insipidus-after-inhalation-sedation-with-sevoflurane-in-a%C3%A2-patient-with-covid-19-associated-acute-respiratory-distress-syndrome
#16
JOURNAL ARTICLE
Johannes Reins, Florian Balling, Christoph Baader, Elfriede Böck, Wolfgang Schöniger, Rene van Erp, Sebastian Eff, Sebastian Hafner
No abstract text is available yet for this article.
October 17, 2023: Anaesthesiologie
https://read.qxmd.com/read/37779064/lithium-induced-nephrogenic-diabetes-insipidus-with-efficacy-of-desmopressin-in-combination-with-thiazide-diuretics-and-non-steroidal-anti-inflammatory-drugs-a-case-report-with-a-review-of-the-literature
#17
JOURNAL ARTICLE
Takanobu Jinnouchi, Munehiro Yoshimoto, Kei Ogino, Tomoatsu Oji, Michio Hayashi
Nephrogenic diabetes insipidus (NDI) is characterized by excessive urination and an inability to concentrate urine. Lithium is the most common cause of acquired NDI. Treatment typically involves thiazide diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs). However, the efficacy of desmopressin in NDI remains unclear. We herein report a case of lithium-induced NDI in a 71-year-old woman with lithium-induced NDI. Thiazide diuretics and NSAIDs reduced the urine output by approximately 40% compared to pretreatment, while the addition of desmopressin reduced it by approximately 70%...
September 29, 2023: Internal Medicine
https://read.qxmd.com/read/37737906/an-exceptional-cause-of-polyuria-polydipsia-syndrome-in-a-10-year-old-boy
#18
JOURNAL ARTICLE
Abir Boussetta, Manel Jellouli, Mariem Hajji, Ezzeddine Abderrahim, Tahar Gargah
Polyuria-polydipsia syndrome is a frequent symptom in pediatrics, primarily attributed to diabetes mellitus. In the context of diabetes insipidus, this syndrome can stem from central or nephrogenic factors. Sjögren's syndrome, an uncommon autoimmune disease in children, can affect multiple organs. Kidney involvement as described in adults is usually related to glomerular or tubular impairment, often linked to distal tubular acidosis. As a kidney involvement during childhood, Sjögren's syndrome has rarely been reported...
February 2024: Pediatric Nephrology
https://read.qxmd.com/read/37674034/structural-and-functional-analysis-of-aquaporin-2-mutants-involved-in-nephrogenic-diabetes-insipidus
#19
JOURNAL ARTICLE
Carl Johan Hagströmer, Jonas Hyld Steffen, Stefan Kreida, Tamim Al-Jubair, Anna Frick, Pontus Gourdon, Susanna Törnroth-Horsefield
Aquaporins are water channels found in the cell membrane, where they allow the passage of water molecules in and out of the cells. In the kidney collecting duct, arginine vasopressin-dependent trafficking of aquaporin-2 (AQP2) fine-tunes reabsorption of water from pre-urine, allowing precise regulation of the final urine volume. Point mutations in the gene for AQP2 may disturb this process and lead to nephrogenic diabetes insipidus (NDI), whereby patients void large volumes of highly hypo-osmotic urine. In recessive NDI, mutants of AQP2 are retained in the endoplasmic reticulum due to misfolding...
September 6, 2023: Scientific Reports
https://read.qxmd.com/read/37663626/-lithium-induced-nephrogenic-diabetes-insipidus-during-acute-intoxication-a-case-report
#20
Sara Echater, Mohammed Hasnaoui, Evelyne Lechner
In case of dehydration, lithium can cause acute intoxication. This picture is mainly manifested by neurological disorders that can go as far as coma, digestive disorders, hydroelectrolytic disorders, and cardiovascular disorders. We report the case of a patient followed for bipolar disorder for 20 years and treated with lithium for 14 years and who presented an acute lithium intoxication resulting from a diabetes insipidus. Our objective is to underline the importance of good hydration and strict monitoring of lithium levels especially in situations favouring dehydration, notably the polyuria of diabetes insipidus...
2023: Pan African Medical Journal
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