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https://www.readbyqxmd.com/read/27754556/meta-analysis-of-two-studies-in-the-presence-of-heterogeneity-with-applications-in-rare-diseases
#1
Tim Friede, Christian Röver, Simon Wandel, Beat Neuenschwander
Random-effects meta-analyses are used to combine evidence of treatment effects from multiple studies. Since treatment effects may vary across trials due to differences in study characteristics, heterogeneity in treatment effects between studies must be accounted for to achieve valid inference. The standard model for random-effects meta-analysis assumes approximately normal effect estimates and a normal random-effects model. However, standard methods based on this model ignore the uncertainty in estimating the between-trial heterogeneity...
October 18, 2016: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/27649249/the-rescue-and-rehabilitation-of-koalas-phascolarctos-cinereus-in-southeast-queensland
#2
Emily Burton, Andrew Tribe
Koala populations in southeast Queensland are under threat from many factors, particularly habitat loss, dog attack, vehicle trauma and disease. Animals not killed from these impacts are often rescued and taken into care for rehabilitation, and eventual release back to the wild if deemed to be healthy. This study investigated current rescue, rehabilitation and release data for koalas admitted to the four major wildlife hospitals in southeast Queensland (Australia Zoo Wildlife Hospital (AZWH), Currumbin Wildlife Sanctuary Hospital (CWH), Moggill Koala Hospital (MKH) and the Royal Society for the Prevention Against Cruelty to Animals Wildlife Hospital at Wacol (RSPCA)), and suggests aspects of the practice that may be changed to improve its contribution to the preservation of the species...
2016: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/27611644/interaction-studies-of-human-prion-protein-huprp109-111-methionine-lysine-histidine-tripeptide-model-with-transition-metal-cations
#3
C Pitchumani Violet Mary, R Shankar, S Vijayakumar, P Kolandaivel
In the present study, the coordination bonds between the Methionine-Lysine-Histidine (Ac-MKH-NHMe) tripeptide model associated with the fifth metal binding site, which triggers the β-sheet formation of human prion protein and the divalent metal cations such as Mn(2+), Cu(2+) and Zn(2+) were studied using B3LYP and M052X levels of theory with LANL2DZ basis set. For each transition divalent metal cation, three different coordination modes (4N, 3NO, and 2NSO) were analyzed. The present result reveals that overall structural parameters of MKH model tripeptide are altered due to the interaction of divalent metal cations...
September 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/27020468/correction-of-congenital-penoscrotal-webbing-in-children-a-retrospective-review-of-three-surgical-techniques
#4
R P Bonitz, M K Hanna
INTRODUCTION: Congenital penoscrotal webbing (PSW) is a condition that leads to penile shortening and is a common cause of delayed circumcision. While various techniques for PSW repair have been described, no comparative studies are currently available. OBJECTIVE: The goal of this study was to validate and critique three commonly utilized techniques for PSW repair. SUBJECTS AND METHODS: A retrospective chart review was performed on all patients who underwent repair for PSW, with or without concomitant surgical procedure, by a single surgeon (MKH) over a 7-year period...
June 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/26987350/novel-effect-of-daflon-and-low-dose-%C3%AE-radiation-in-modulation-of-thioacetamide-induced-hepatic-encephalopathy-in-male-albino-rats
#5
MKh Abdel-Rafei, M M Amin, H F Hasan
This study was designed to evaluate the hepato and neuroprotective activity of Daflon and low-dose γ radiation on thioacetamide (TAA)-induced liver damage and hepatic encephalopathy (HE) in rats. Effect of daily Daflon treatment (100 mg/kg body weight, Per OS (p.o.) for consecutive 3 days) and/or fractionated low-dose γ-radiation (LDR; 0.25 Gy, twice the total dose of 0.5 Gy at the 1st and 3rd day, respectively) was evaluated against TAA (300 mg/kg, intraperitoneal × 3) induced liver damage and HE in rats...
March 16, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/26573817/hartung-knapp-sidik-jonkman-approach-and-its-modification-for-random-effects-meta-analysis-with-few-studies
#6
Christian Röver, Guido Knapp, Tim Friede
BACKGROUND: Random-effects meta-analysis is commonly performed by first deriving an estimate of the between-study variation, the heterogeneity, and subsequently using this as the basis for combining results, i.e., for estimating the effect, the figure of primary interest. The heterogeneity variance estimate however is commonly associated with substantial uncertainty, especially in contexts where there are only few studies available, such as in small populations and rare diseases. METHODS: Confidence intervals and tests for the effect may be constructed via a simple normal approximation, or via a Student-t distribution, using the Hartung-Knapp-Sidik-Jonkman (HKSJ) approach, which additionally uses a refined estimator of variance of the effect estimator...
2015: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/26099058/repeatability-of-associated-phoria-tests
#7
Mosaad Alhassan, Jeffery K Hovis, Ralph B Chou
PURPOSE: H.J. Haase developed a set of tests for measuring associated phoria and stereopsis using a variety of different targets for each. This testing method is known as the MKH-Haase method and it is used commonly in Germany. The aim of this study was to investigate the test-retest repeatability of the distance and near associated phoria tests for the MKH-Haase charts and other clinical tests. METHODS: Horizontal and vertical associated phorias were measured at distance and near for 34 symptomatic and 40 asymptomatic participants with different tests...
August 2015: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/25664136/grey-turner-s-sign-after-modified-kugel-herniorrhaphy
#8
Zhe Fan, Xiaofeng Tian, Yingyi Zhang, Huirong Jing, Jiyong Pan, Shuang Wang
Tension-free hernia repairing techniques is a popular herniorrhaphy for open inguinal hernioplasty and the modified Kugel herniorrhaphy (MKH) is a kind of tension-free hernia repairing technique. The modified Kugel herniorrhaphy (MKH) is a minimally invasive, non-laparoscopic, conventional anterior approach, preperitoneal and sutureless technique. It is well accepted by most people because of few complications and low recurrence rate. A case of an 82-year-old man underwent MKH. After the third day of postoperation, a strange symptom of Grey-Turner's sign appeared and maintained for 10 days...
2014: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25604876/what-is-the-effect-of-matrices-on-cartilage-repair-a-systematic-review
#9
REVIEW
James D Wylie, Melissa K Hartley, Ashley L Kapron, Stephen K Aoki, Travis G Maak
BACKGROUND: Articular cartilage has minimal endogenous ability to undergo repair. Multiple chondral restoration strategies have been attempted with varied results. QUESTIONS/PURPOSES: The purpose of our review was to determine: (1) Does articular chondrocyte transplantation or matrix-assisted articular chondrocyte transplantation provide better patient-reported outcomes scores, MRI morphologic measurements, or histologic quality of repair tissue compared with microfracture in prospective comparative studies of articular cartilage repair; and (2) which available matrices for matrix-assisted articular chondrocyte transplantation show the best patient-reported outcomes scores, MRI morphologic measurements, or histologic quality of repair tissue? METHODS: We conducted a systematic review of PubMed, CINAHL, and MEDLINE from March 2004 to February 2014 using keywords determined to be important for articular cartilage repair, including "cartilage", "chondral", "cell source", "chondrocyte", "matrix", "augment", "articular", "joint", "repair", "treatment", "regeneration", and "restoration" to find articles related to cell-based articular cartilage repair of the knee...
May 2015: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/25416411/enhanced-antitumor-effects-of-novel-intracellular-delivery-of-an-active-form-of-menaquinone-4-menahydroquinone-4-into-hepatocellular-carcinoma
#10
Shuichi Setoguchi, Daisuke Watase, Kazuhisa Matsunaga, Misa Matsubara, Yohei Kubo, Mariko Kusuda, Nami Nagata-Akaho, Munechika Enjoji, Manabu Nakashima, Morishige Takeshita, Yoshiharu Karube, Jiro Takata
Reduced cellular uptake of menaquinone-4 (MK-4), a vitamin K2 homolog, in human hepatocellular carcinoma (HCC) limits its usefulness as a safe long-term antitumor agent for recurrent HCC and produces des-γ-carboxy prothrombin (DCP). We hypothesized that effective delivery of menahydroquinone-4 (MKH), the active form of MK-4 for γ-glutamyl carboxylation, into HCC cells is critical for regulating HCC growth, and may enable it to be applied as a safe antitumor agent. In this study, we verified this hypothesis using menahydroquinone-4 1,4-bis-N,N-dimethylglycinate hydrochloride (MKH-DMG), a prodrug of MKH, and demonstrated its effectiveness...
February 2015: Cancer Prevention Research
https://www.readbyqxmd.com/read/25181837/influence-of-bile-acid-derivates-on-morphine-analgesic-effect-in-mice
#11
Velibor Vasović, Sasa Vukmirović, Momir Mikov, Ivan Mikov, Zorana Budakov, Nebojsa Stilinović, Boris Milijasević
BACKGROUND/AIM: It is known that bile acids improve the absorption, bioavailability and pharmacodynamic characteristics of some drugs. Morphine analgesia is produced by activation of opioid receptors within the central nervous system (CNS) at both spinal and supraspinal levels. Since a morphine molecule contains 3 polar groups and therefore hard to transfer through the blood-brain barrier, the aim of the study was to examine the potential influence of bile acids derivates, namely sodium salt of monoketocholic acid (MKH-Na) and methyl ester of monoketocholic acid (MKH-Me), on analgesic effect of morphine...
August 2014: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/23813118/modified-kugel-herniorrhaphy-using-standardized-dissection-technique-of-the-preperitoneal-space-long-term-operative-outcome-in-consecutive-340-patients-with-inguinal-hernia
#12
K Suwa, S Nakajima, K Hanyu, T Suzuki, T Okamoto, K Yanaga
PURPOSE: The aim of this study was to evaluate the outcome, with a special reference to recurrence and postoperative chronic pain, of the modified Kugel herniorrhaphy (MKH) using standardized dissection of the preperitoneal space. PATIENTS AND METHODS: Operative results were examined based on medical records and questionnaire surveys in 340 consecutive cases of MKH performed at a single institution. The operation was performed with an original 3-stage dissection of the preperitoneal space only via the internal inguinal ring...
December 2013: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/21808963/low-versus-high-dose-combination-of-midazolam-ketamine-for-oral-premedication-in-children-for-ophthalmologic-surgeries
#13
RANDOMIZED CONTROLLED TRIAL
V Darlong, D Shende, M Singh, R Garg, R Pandey, J Punj
INTRODUCTION: Midazolam and ketamine are useful for oral premedication in children to allay anxiety. We compared the effects of midazolam with a combination of high- and low-dose ketaminemidazolam as an oral premedication. METHODS: This is a randomised, controlled prospective study conducted in 87 children who were scheduled for ophthalmologic surgeries. Group M received oral midazolam 0.5 mg/kg, Group MKL received oral midazolam 0.25 mg/kg and ketamine 3 mg/kg, and Group MKH received midazolam 0...
July 2011: Singapore Medical Journal
https://www.readbyqxmd.com/read/21495270/influence-of-bile-acid-derivates-on-tramadol-analgesic-effect-in-mice
#14
V Vasovic, Sasa Vukmirovic, M Pjevic, I Mikov, M Mikov, V Jakovljevic
Influence of two newly synthesized bile acids derivates, namely sodium salt of monoketocholic acid MKH-Na and methyl ester of monoketocholic acid MKH-Me on tramadol (12.5 mg/kg oral and intramuscular) analgesic effect was examined in this research. Analgesic effect was measured by antinociceptive hot plate method. Interaction was estimated by detection of changes in analgesic effect of tramadol combined with bile acids (subcutaneous administration of 4 mg/kg 20 min before tramadol) compared to analgesic effect of the same dose of tramadol given alone...
September 2010: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/21388927/the-effect-of-n-methyl-d-aspartate-receptor-antagonists-on-d-l-homocysteine-thiolactone-induced-seizures-in-adult-rats
#15
A Rašić-Marković, D Hrnčić, D Djurić, D Macut, H Lončar-Stevanović, Olivera Stanojlović
The aim of our study was to investigate the effects of ifenprodil and MK-801 on D,L-homocysteine thiolactone induced seizures in adult rats.Male Wistar rats were divided into following groups: 1. Saline-treated (C, n=10); 2. D,L-homocysteine thiolactone 8 mmol/kg, i.p. (H, n=7); 3. Ifenprodil 20 mg/kg i.p. (IF, n=8); 4. MK-801 0.5 mg/kg, i.p. (MK, n=8) and 5. Groups that received IF or MK 30 minutes prior to H (IFH, n=8 and MKH, n=8). Seizure behavior was assessed by incidence, latency, number and intensity of seizure episodes...
March 2011: Acta Physiologica Hungarica
https://www.readbyqxmd.com/read/17702197/anthracycline-based-combined-chemotherapy-in-the-mouse-model
#16
M Popovic, J Kolarovic, M Mikov, S Trivic, B Kaurinovic
Our research was aimed at establishing if and how selenium (Se) ion, N-acetylcysteine (NAC), sodium salt of monoketocholic acid (MKH) and superoxide-dismutase (SOD), administered in the experimental animal model, could affect the possible cytotoxicity associated with anthracycline-based combined chemotherapy with doxorubicin, vincristine and prednisolone (DVP). The following biochemical parameters were investigated: the extent of lipid peroxidation (LPx), and the activity of peroxidase (Px), catalase (CAT), glutathione-peroxidase (GSHPx), and xanthine-oxidase (XOD)...
April 2007: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/17260317/-do-prism-corrections-according-to-h-j-haase-affect-ocular-prevalence
#17
V Schroth, W Jaschinski
BACKGROUND: For prism correction of associated phoria (at 5-6 m viewing distance), Hans-Joachim Haase developed--among other tests--the prevalence test, which consists of a central fixation target and two triangles that appear stereoscopically about 1.5 m in front of or behind the fixation target; the vertex of each triangle is directed towards the centre of the fixation target. Only when both eyes contribute equally to the perception of visual directions do the triangles appear centred (equivalence), while any perceived horizontal offset between the triangles and fixation target indicates a prevalence of one eye...
January 2007: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/12548469/-do-prisms-according-to-hans-joachim-haase-influence-ocular-prevalence
#18
Miriam Kromeier, Christina Schmitt, Michael Bach, Guntram Kommerell
BACKGROUND: Ocular prevalence is defined as an unequal weighting of the eyes in the directional perception of stereo objects. Opinions differ as to the cause and relevance of ocular prevalence. Hans-Joachim Haase suggested that ocular prevalence is due to fixation disparity, brought about by incomplete compensation of heterophoria. He further suggested that prismatic spectacles determined by his "measuring and correcting methodology" (MKH) could restore bicentral fixation and thus establish a perceptual balance between both eyes...
December 2002: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/12136437/-do-prisms-according-to-hans-joachim-haase-improve-stereoacuity
#19
COMPARATIVE STUDY
Miriam Kromeier, Christina Schmitt, Michael Bach, Guntram Kommerell
BACKGROUND: The "Measuring and Correcting Methodology" after H.-J. Haase (MKH) aims at converting "fixation disparity" into bicentral fixation, using prismatic spectacles. In the context of the MKH, fixation disparity is diagnosed by a series of subjective tests. According to H.-J. Haase, a long-standing fixation disparity can lead to "disparate correspondence" between the central areas of both retinae, which consolidates the fixation disparity and gradually converts a "young" into an "old fixation disparity"...
June 2002: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/11840793/-prism-correction-in-heterophoria
#20
REVIEW
G Kommerell, M Kromeier
Unlike heterotropia (= manifest strabismus), heterophoria (= latent strabismus) is not a primarily existing condition but is a reaction to an interruption of the sensory-motor feedback control system. The reaction consists of a deviation from the orthovergence position. Binocular vision causes a continuous calibration of the vergence position. This "orthophorisation" explains that in most persons, heterophoria differs only slightly from zero. Nevertheless, a small heterophoria is common (70-80% of the population)...
January 2002: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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