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https://www.readbyqxmd.com/read/29655904/3d-printed-controlled-release-tritherapeutic-tablet-matrix-for-advanced-anti-hiv-1-drug-delivery
#1
Margaret Siyawamwaya, Lisa C du Toit, Pradeep Kumar, Yahya E Choonara, Pierre P P D Kondiah, Viness Pillay
PURPOSE: A 3D-Bioplotter® was employed to 3D print (3DP) a humic acid-polyquaternium 10 (HA-PQ10) controlled release fixed dose combination (FDC) tablet comprising of the anti-HIV-1 drugs, efavirenz (EFV), tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC). METHODS: Chemical interactions, surface morphology and mechanical strength of the FDC were ascertained. In vitro drug release studies were conducted in biorelevant media followed by in vivo study in the large white pigs, in comparison with a market formulation, Atripla® ...
April 12, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29652327/dual-reference-digital-holographic-interferometry-for-analyzing-high-density-gradients-in-fluid-mechanics
#2
Jean-Michel Desse, François Olchewsky
This Letter proposes a dual-reference digital holographic interferometer for analyzing the high refractive index encountered in transonic and supersonic flows. For that, a Wollaston prism is inserted in the reference arm in order to simultaneously generate two orthogonally polarized reference waves. As a consequence, recorded interferograms contain two crossed and perpendicular interference patterns that give two orders fully separated in the Fourier spectrum. It is then possible to analyze a transparent object regardless of the orientation of the refractive index gradient using the two phase maps reconstructed with each of the two first interference orders...
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29651526/surface-plasmon-resonance-sensing-from-purified-biomolecules-to-intact-cells
#3
Yu-Wen Su, Wei Wang
Surface plasmon resonance (SPR) has become a well-recognized label-free technique for measuring the binding kinetics between biomolecules since the invention of the first SPR-based immunosensor in 1980s. The most popular and traditional format for SPR analysis is to monitor the real-time optical signals when a solution containing ligand molecules is flowing over a sensor substrate functionalized with purified receptor molecules. In recent years, rapid development of several kinds of SPR imaging techniques have allowed for mapping the dynamic distribution of local mass density within single living cells with high spatial and temporal resolutions and reliable sensitivity...
April 12, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29650957/two-dimensional-materials-in-functional-three-dimensional-architectures-with-applications-in-photodetection-and-imaging
#4
Wonho Lee, Yuan Liu, Yongjun Lee, Bhupendra K Sharma, Sachin M Shinde, Seong Dae Kim, Kewang Nan, Zheng Yan, Mengdi Han, Yonggang Huang, Yihui Zhang, Jong-Hyun Ahn, John A Rogers
Efficient and highly functional three-dimensional systems that are ubiquitous in biology suggest that similar design architectures could be useful in electronic and optoelectronic technologies, extending their levels of functionality beyond those achievable with traditional, planar two-dimensional platforms. Complex three-dimensional structures inspired by origami, kirigami have promise as routes for two-dimensional to three-dimensional transformation, but current examples lack the necessary combination of functional materials, mechanics designs, system-level architectures, and integration capabilities for practical devices with unique operational features...
April 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29644842/ito-tin-ito-sandwiches-for-near-infrared-plasmonic-materials
#5
Chaonan Chen, Zhewei Wang, Ke Wu, Haining Chong, Zemin Xu, Hui Ye
ITO-based sandwich structures with ultrathin (<10 nm) titanium nitride (TiN) insertion are investigated as near-infrared (NIR) plasmonic materials. The structural, electrical and optical properties reveal the improvement of the sandwich structures stemmed from TiN insertion. TiN is a well-established alternative to noble metals such as gold, elevating the electron conductivity of sandwich structures as its thickness increases. Dielectric permittivities of TiN and top ITO layers show TiN-thickness-dependent properties, which lead to moderate and tunable effective permittivities for the sandwiches...
April 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29644472/pictorial-representation-of-illness-and-self-measure-revised-2-prism-r2-an-effective-tool-to-assess-perceived-burden-of-thyroid-cancer-in-mainland-china
#6
Yanbo Wang, Suyun Fan, Hongbiao Wang, Li Li, Yanyan Jia, Li Chai
PURPOSE: Thyroid cancer, especially differentiated thyroid cancer (DTC), is a highly prevalent chronic disease that is known to cause considerable distress, related both to the high recurrence and treatment of the disease. The Pictorial Representation of Illness and Self Measure-Revised 2 (PRISM-R2) has been developed as a visual measure to assess suffering. The aim of this study was to evaluate the ability of the instrument to identify patients with DTC with different levels of suffering who may need additional support care...
April 11, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29643888/spectrum-of-complications-of-severe-dka-in-children-in-pediatric-intensive-care-unit
#7
Qalab Abbas, Saba Arbab, Anwar Ul Haque, Khadija Nuzhat Humayun
Objectives: To describe the spectrum of complications of Diabetic Ketoacidosis (DKA) observed in children admitted with severe DKA. Methods: Retrospective review of the medical records of all children admitted with the diagnosis of severe DKA in Pediatric Intensive Care Unit (PICU) of the Aga Khan University Hospital, from January 2010 to December 2015 was done. Data was collected on a structured proforma and descriptive statistics were applied. Results: Total 37 children were admitted with complicated DKA (1...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29628378/pegvaliase-for-the-treatment-of-phenylketonuria-a-pivotal-double-blind-randomized-discontinuation-phase-3-clinical-trial
#8
Cary O Harding, R Stephen Amato, Mary Stuy, Nicola Longo, Barbara K Burton, John Posner, Haoling H Weng, Markus Merilainen, Zhonghua Gu, Joy Jiang, Jerry Vockley
INTRODUCTION: Pegvaliase is a recombinant Anabaena variabilis phenylalanine ammonia lyase (PAL) enzyme under investigation for treatment of adult phenylketonuria (PKU). This manuscript describes results of a randomized discontinuation trial (RDT) designed to evaluate the effects of pegvaliase treatment on blood phenylalanine (Phe) and neuropsychiatric outcomes in adults with PKU. METHODS: PRISM-2 is a 4-part, Phase 3 study that enrolled adults with PKU receiving pegvaliase treatment (initiated in a prior Phase 2 or Phase 3 study)...
March 18, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29625442/improved-binocular-outcomes-following-binocular-treatment-for-childhood-amblyopia
#9
Krista R Kelly, Reed M Jost, Yi-Zhong Wang, Lori Dao, Cynthia L Beauchamp, Joel N Leffler, Eileen E Birch
Purpose: Childhood amblyopia can be treated with binocular games or movies that rebalance contrast between the eyes, which is thought to reduce depth of interocular suppression so the child can experience binocular vision. While visual acuity gains have been reported following binocular treatment, studies rarely report gains in binocular outcomes (i.e., stereoacuity, suppression) in amblyopic children. Here, we evaluated binocular outcomes in children who had received binocular treatment for childhood amblyopia...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29622820/high-risk-of-coagulopathy-among-type-2-diabetes-mellitus-clients-at-a-municipal-hospital-in-ghana
#10
Richard Kd Ephraim, Yaw A Awuku, Patrick Adu, Lord Tw Ampomah, Prince Adoba, Solomon Panford, Jerry Pk Ninnoni, Hope Agbodzakey
Background: Persistent hyperglycaemia in diabetes mellitus causes coagulopathies due to glycation of haemoglobin, prothrombin, fibrinogen and other proteins involved in the clotting mechanism. Shortened activated partial thromboplastin time (APTT) and prothrombin time (PT) reflect hypercoagulable state, which is associated with an increased thrombotic risk and adverse cardiovascular effects. This study assessed the coagulation profile of type 2 diabetes mellitus (T2DM) clients at a municipal hospital in Ghana...
September 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/29617209/differences-in-the-stimulus-accommodative-convergence-accommodation-ratio-using-various-techniques-and-accommodative-stimuli
#11
Tsukasa Satou, Misae Ito, Yuma Shinomiya, Yoshiaki Takahashi, Naoto Hara, Takahiro Niida
PURPOSE: To investigate differences in the stimulus accommodative convergence/accommodation (AC/A) ratio using various techniques and accommodative stimuli, and to describe a method for determining the stimulus AC/A ratio. METHODS: A total of 81 subjects with a mean age of 21 years (range, 20-23 years) were enrolled. The relationship between ocular deviation and accommodation was assessed using two methods. Ocular deviation was measured by varying the accommodative requirement using spherical plus/minus lenses to create an accommodative stimulus of 10...
April 4, 2018: Strabismus
https://www.readbyqxmd.com/read/29616870/the-influence-of-lymphoid-reconstitution-kinetics-on-clinical-outcomes-in-allogeneic-stem-cell-transplantation
#12
David J Kobulnicky, Roy T Sabo, Shashank Sharma, Ali S Shubar Ali, Kristen M Kobulnicky, Catherine H Roberts, William B Clark, Harold M Chung, John M McCarty, Amir A Toor
Lymphoid recovery following myeloablative stem cell transplantation (SCT) displays a logistic pattern of exponential growth followed by a plateau. Within this logistic framework, lymphoid recovery is characterized by the parameters R (slope of ascent), a (time of maximal rate of ascent) and K (plateau), the 'steady-state' lymphocyte count. A retrospective analysis of allogeneic SCT performed from 2008 to 2013 was undertaken to compare lymphoid recovery and clinical outcomes in 131 patients with acute myelogenous leukemia, acute lymphocytic leukemia, and myelodysplastic syndromes...
April 4, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29614331/carnitine-levels-and-mutations-in-the-slc22a5-gene-in-faroes-patients-with-parkinson-s-disease
#13
Súsanna Crooks, Sára Bech, Jónrit Halling, Debes H Christiansen, Beate Ritz, Maria Skaalum Petersen
INTRODUCTION: Mitochondrial dysfunction, oxidative stress and energy production have been implicated in the etiology of Parkinson's disease (PD). Several agents are under investigation for potential neuroprotective effects including acetyl-L-carnitine (ALC). OBJECTIVE: To investigate whether low carnitine levels and mutations in the SLC22A5 gene encoding the carnitine transporter are associates with Parkinson's disease (PD) risk in the Faroe Islands where the prevalence of both PD and carnitine transporter deficiency is high...
March 31, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29604742/note-tandem-kirkpatrick-baez-microscope-with-sixteen-channels-for-high-resolution-laser-plasma-diagnostics
#14
Shengzhen Yi, Zhe Zhang, Qiushi Huang, Zhong Zhang, Zhanshan Wang, Lai Wei, Dongxiao Liu, Leifeng Cao, Yuqiu Gu
Multi-channel Kirkpatrick-Baez (KB) microscopes, which have better resolution and collection efficiency than pinhole cameras, have been widely used in laser inertial confinement fusion to diagnose time evolution of the target implosion. In this study, a tandem multi-channel KB microscope was developed to have sixteen imaging channels with the precise control of spatial resolution and image intervals. This precise control was created using a coarse assembly of mirror pairs with high-accuracy optical prisms, followed by precise adjustment in real-time x-ray imaging experiments...
March 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29604733/stress-distribution-and-pressure-bearing-capacity-of-a-high-pressure-split-cylinder-die-with-prism-cavity
#15
Liang Zhao, Mingzhe Li, Liyan Wang, Erhu Qu, Zhuo Yi
A novel high-pressure belt-type die with a split-type cylinder is investigated with respect to extending its lifetime and improving its pressure bearing capacity. Specifically, a tungsten carbide cylinder is split into several parts along the radial direction with a prism-type cavity. In this paper, the cylinders with different split numbers are chosen to study the stress distribution and compare them with the traditional belt-type die. The simulation results indicate that the split cylinder has much smaller stress than those in the belt-type cylinder, and the statistical analysis reveals that the split-pressure cylinder is able to bear higher pressure...
March 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29602686/prevalence-of-esophoria-in-concussed-patients
#16
Barry Tannen, Kalynn Good, Kenneth J Ciuffreda, Kelsey J Moore
PURPOSE: To assess the prevalence of esophoria at near in concussed patients in a neuro-optometric private practice setting. METHODS: A retrospective analysis was performed involving a chart review in a neuro-optometric, private practice setting of consecutive patients with a medical diagnosis of concussion from January 1st 2016 to December 31st 2016. A total of 71 patients were included in the analysis. All received a comprehensive vision examination, with a near vision emphasis...
March 27, 2018: Journal of Optometry
https://www.readbyqxmd.com/read/29602450/impact-of-environmental-adaptation-on-tear-film-assessments
#17
R Fagehi
PURPOSE: The purpose of this study was to investigate the effect of ocular environmental adaptation on clinical tear film assessment. METHOD: Thirty subjects (male, mean age 23±2.5) participated in this study. A number of clinical tear film tests were applied, including: fluorescein tear break-up time (FTBUT), Schirmer test and tear prism height test (TPH). The tear physiology of each subject was evaluated twice, once immediately when they arrived from the external environment, and then after 30minutes adaptation in the exam room environment...
March 27, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29601119/employing-a-unique-unsaturated-th4-site-in-a-mesoporous-thorium-organic-framework-for-kr-xe-uptake-and-separation
#18
Yanlong Wang, Wei Liu, Zhuanling Bai, Tao Zheng, Mark A Silver, Yuxiang Li, Yaxing Wang, Xia Wang, Juan Diwu, Zhifang Chai, Shuao Wang
Actinide based metal-organic frameworks (MOFs) are unique not only because compared to the transition metal and lanthanide systems, they are substantially less explored, but also owing to the uniqueness of actinide ions in bonding and coordination. We report here a new 3D thorium-organic framework (SCU-11) that contains a series of cages with an effective size of ca. 21  24 Å. Th4+ in SCU-11 is 10-coordinate with a new bicapped square prism coordination geometry, which has never been documented for any metal cation complexes before...
March 30, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29600183/the-relationship-between-abduction-deficit-and-reoperation-among-patients-with-infantile-esotropia
#19
Zhale Rajavi, Hamideh Sabbaghi, Pooya Torkian, Narges Behradfar, Mehdi Yaseri, Mohadeseh Feizi, Mohammad Faghihi, Kourosh Sheibani
AIM: To determine the relationship between abduction deficit and reoperation among patients with infantile esotropia (IET). METHODS: The records of 216 patients (432 eyes) with IET who underwent surgery, from 2010 to 2015 were studied. Patients with IET whose deviation appeared before 6mo of age and had stable preoperative deviation in two examinations with at least 2wk apart and a minimum 3mo postoperative follow up were included. Cases with early onset accommodative esotropia, congenital cataract, retinopathy of prematurity (ROP), manifest nystagmus, fundus lesions, neurologic and ophthalmic anomalies, 6th nerve palsy and Duane's syndrome were excluded...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29582226/a-long-term-feed-supplementation-based-on-phosphate-binders-in-feline-chronic-kidney-disease
#20
E Biasibetti, E Martello, M Bigliati, I Biasato, T Cocca, N Bruni, M T Capucchio
Chronic kidney disease (CKD) is a very common disorder in elderly cats. A proper renal diet represents the most efficient therapeutic intervention to improve survival and life quality in feline patients with 3 and 4 International Renal Interest Society (IRIS) stages. Twenty cats were selected in this study. Ten were administered the dietary supplementation for 360 days and the other ten, whose owners did not give consent for any supplemental therapies apart from the renal diet, were selected from a clinical database and used as control group...
March 26, 2018: Veterinary Research Communications
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