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https://www.readbyqxmd.com/read/28535565/ephrinb-ephb-signaling-induces-hyperalgesia-through-erk5-creb-pathway-in-rats
#1
Li-Na Yu, Li-Hong Sun, Min Wang, Lie-Ju Wang, Ying Wu, Jing Yu, Wen-Na Wang, Feng-Jiang Zhang, Xue Li, Min Yan
BACKGROUND: There are numerous studies implicating that EphB receptors and ephrinB ligands play important roles in modulating the transduction of spinal nociceptive information. EphrinB-EphB signaling may contribute to hyperalgesia via various kinds of downstream molecules, the mechanisms of which have not been completely understood. OBJECTIVE: The aim of the present study was to identify whether ephrinB-EphB signaling could contribute to hyperalgesia through ERK5/CREB pathway...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28534342/the-effect-of-preoperative-occlusion-therapy-on-long-term-outcome-after-surgery-for-early-onset-exotropia
#2
Kwang Hoon Shin, Iris Naheah Kim, Hae Jung Paik
PURPOSE: To investigate the effect of preoperative part-time occlusion therapy on long-term surgical success in early-onset exotropia. METHODS: The medical records of patients who underwent surgery for exotropia with onset before the first year of age and who were followed for ≥3 years were reviewed. Patients were divided into two groups according to the degree of compliance with part-time occlusion therapy: the good compliance group (>50% adherence rate) and the poor compliance group (≤50% adherence rate)...
May 11, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28515694/fam20a-gene-mutation-amelogenesis-or-ectopic-mineralization
#3
Guilhem Lignon, Fleur Beres, Mickael Quentric, Stephan Rouzière, Raphael Weil, Muriel De La Dure-Molla, Adrien Naveau, Renata Kozyraki, Arnaud Dessombz, Ariane Berdal
Background and objective:FAM20A gene mutations result in enamel renal syndrome (ERS) associated with amelogenesis imperfecta (AI), nephrocalcinosis, gingival fibromatosis, and impaired tooth eruption. FAM20A would control the phosphorylation of enamel peptides and thus enamel mineralization. Here, we characterized the structure and chemical composition of unerupted tooth enamel from ERS patients and healthy subjects. Methods: Tooth sections were analyzed by Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), X-Ray Diffraction (XRD), and X-Ray Fluorescence (XRF)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28514339/-increased-oral-fluid-remineraling-function-by-endogenous-and-exogenous-saturation-methods-of-its-mineral-complexes
#4
O G Avraamova, Yu A Ippolitov, Ya A Plotnikova, P V Seredin, D V Goloshapov, E O Aloshina
RELEVANCE: One of the most common problems in modern caries prevention is the development of techniques to increase tooth resistance to the effects of cariogenic factors. Therefore, research is needed to study the chemical composition of tissues like teeth and body fluids surrounding the tooth to prevent demineralization process. The purpose of determining the effectiveness of work- and correlation relationship between endo saturation exogenous methods oral liquid mineral complexes. MATERIAL AND METHODS: In 95 patients analyzed the chemical composition and structure of the oral fluid by IR spectroscopy...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28513884/oxidized-quasi-carbon-nitride-quantum-dots-inhibit-ice-growth
#5
Guoying Bai, Zhiping Song, Hongya Geng, Dong Gao, Kai Liu, Shuwang Wu, Wei Rao, Liangqia Guo, Jianjun Wang
Antifreeze proteins (AFPs), a type of high-efficiency but expensive and often unstable biological antifreeze, have stimulated substantial interest in the search for synthetic mimics. However, only a few reported AFP mimics display thermal hysteresis, and general criteria for the design of AFP mimics remain unknown. Herein, oxidized quasi-carbon nitride quantum dots (OQCNs) are synthesized through an up-scalable bottom-up approach. They exhibit thermal-hysteresis activity, an ice-crystal shaping effect, and activity on ice-recrystallization inhibition...
May 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28511704/the-use-of-kdna-minicircle-subclass-relative-abundance-to-differentiate-between-leishmania-l-infantum-and-leishmania-l-amazonensis
#6
Marcello Ceccarelli, Luca Galluzzi, Aurora Diotallevi, Francesca Andreoni, Hailie Fowler, Christine Petersen, Fabrizio Vitale, Mauro Magnani
BACKGROUND: Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia). Several qPCR-based molecular diagnostic approaches have been reported for detection and quantification of Leishmania species. Many of these approaches use the kinetoplast DNA (kDNA) minicircles as the target sequence. These assays had potential cross-species amplification, due to sequence similarity between Leishmania species. Previous works demonstrated discrimination between L...
May 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28511117/conditioned-medium-from-relapsing-remitting-multiple-sclerosis-patients-reduces-the-expression-and-release-of-inflammatory-cytokines-induced-by-lps-gingivalis-in-thp-1-and-mo3-13-cell-lines
#7
Patrizia Ballerini, Francesca Diomede, Nicola Petragnani, Simona Cicchitti, Ilaria Merciaro, Marcos F X B Cavalcanti, Oriana Trubiani
The present research was aimed at evaluating the effect of the conditioned medium (CM) from human periodontal ligament stem cells (hPDLSCs) obtained from healthy donors (hPDLSCs-CM) and from Relapsing-Remitting Multiple Sclerosis patients (RR-MS-CM) on inflammatory response induced by Porphyromonas gingivalis lipopolysaccharide (LPS-G) in a monocytoid human cell line (THP-1) and human oligodendrocyte cell line (MO3.13). Human periodontal ligament biopsies were carried out from control donor patients and selected RR-MS donors...
May 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28510776/patient-characteristics-and-surgical-approach-impacting-simultaneous-to-alternate-prism-cover-test-disparity-after-exotropia-surgery-a-quantitative-look-at-the-difference-in-motor-outcomes
#8
Pavlina S Kemp, Yoon-Hee Chang, Patrice Melvin, Linda R Dagi
PURPOSE: To investigate the relationship between simultaneous prism and cover test (SPCT) and alternate prism and cover test (APCT) outcomes after exotropia surgery, and to identify characteristics associated with significant disparity between them. METHODS: Review of sensorimotor outcomes 2 to 6 months after exotropia surgery identified patients with alignment documented by both SPCT and APCT at the same examination. Two hundred seventy-four and 319 patients had both measurements recorded at distance and near, respectively...
May 15, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28510770/inferior-oblique-overaction-anterior-transposition-versus-myectomy
#9
Zhale Rajavi, Mohadeseh Feizi, Narges Behradfar, Mehdi Yaseri, Shima Sayanjali, Tahmine Motevaseli, Hamideh Sabbaghi, Mohammad Faghihi
PURPOSE: To compare the efficacy of inferior oblique myectomy and anterior transposition for correcting inferior oblique overaction (IOOA). METHODS: This retrospective study was conducted on 56 patients with IOOA who had either myectomy or anterior transposition of the inferior oblique muscle from 2010 to 2015. The authors compared preoperative and postoperative inferior oblique muscle function grading (-4 to +4) as the main outcome measure and vertical and horizontal deviation, dissociated vertical deviation (DVD), and A- and V-pattern between the two surgical groups as secondary outcomes...
May 15, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28510769/comparison-of-objective-and-subjective-techniques-of-strabismus-measurement-in-adults-with-normal-retinal-correspondence
#10
Derek P Bitner, Ore-Ofe O Adesina, Kai Ding, Bradley K Farris, R Michael Siatkowski
PURPOSE: Accurate measurement of strabismus is vital to proper diagnosis and treatment. Objective and subjective measurement techniques can be used. The authors hypothesized that subjective measurement techniques would measure larger deviations than objective ones. METHODS: Adults with strabismus, visual acuity greater than 20/50 in each eye, and normal retinal correspondence were measured in primary gaze at distance and near using the alternate prism and cover test and the red glass test...
May 15, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28507420/some-hematological-and-biochemical-parameters-of-different-goat-breeds-in-sultanate-of-oman-a-preliminary-study
#11
Shahab Al-Bulushi, Turke Shawaf, Afaf Al-Hasani
AIM: In Sultanate of Oman, goats are considered as one of the most important livestock in which there are many breeds of goat such as Batinah, Jabali, Dhofari, Jabal Al-Akhdar, Sahrawi, and Sahrawi Musandam. Little hematological and biochemical information is known on Omani goat breeds; therefore, the main purpose of this study was to determine reference baseline data regarding hematological and biochemical values of different Omani goat breeds. MATERIALS AND METHODS: A total of 30 healthy animals of different Omani goat breeds (Jabali, Jabal Al-Akhdar, Sahrawi, and Sahrawi Musandam) were selected randomly from different areas in Sultanate of Oman...
April 2017: Veterinary World
https://www.readbyqxmd.com/read/28506651/a-load-to-fracture-and-strain-analysis-of-monolithic-zirconia-cantilevered-frameworks
#12
Faris A Alshahrani, Burak Yilmaz, Jeremy D Seidt, Edwin A McGlumphy, William A Brantley
STATEMENT OF PROBLEM: The dimensions of implant-supported fixed cantilevered prostheses are important to prevent mechanical and biological complications. Information on the optimum thickness and cantilever length for improving the strength of zirconia cantilevered frameworks is limited in the literature. PURPOSE: The purpose of this in vitro study was to investigate the effect of cantilever length and occlusocervical thickness on the load-to-fracture and strain distribution of zirconia frameworks...
May 12, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28505449/interfacial-water-arrangement-in-the-ice-bound-state-of-an-antifreeze-protein-a-molecular-dynamics-simulation-study
#13
Uday Sankar Midya, Sanjoy Bandyopadhyay
Molecular dynamics (MD) simulations have been carried out to study the heterogeneous ice nucleation on modeled peptide surfaces. Simulations show that large peptide surfaces made by TxT (threonine-x-threonine) motifs with the arrangements of threonine (Thr) residues identical to the periodic arrangements of waters on either the basal or prism plane of ice are capable of ice nucleation. Nucleated ice plane is the (0001) basal plane of hexagonal ice (Ih) or (111) plane of cubic ice (Ic). However, due to predefined simulation cell dimensions, the ice growth is only observed on the surface where the Thr residues are arranged like the water arrangement on the basal plane of ice Ih...
May 23, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28499831/resolution-of-hypertropia-with-correction-of-consecutive-horizontal-deviation
#14
Rui Hao, Kanxing Zhao, Wei Zhang
BACKGROUND: To study the resolution of hypertropia in patients who undergo horizontal deviation surgery for consecutive esotropia or consecutive exotropia. METHODS: We retrospectively reviewed the records of 23 patients with consecutive esotropia or exotropia who had concomitant vertical tropia. All patients had had surgery for horizontal deviation that required further surgery to correct consecutive horizontal strabismus and had a minimum of six months of postoperative follow-up...
May 9, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28499402/erk-signaling-is-required-for-vegf-a-vegfr2-induced-differentiation-of-porcine-adipose-derived-mesenchymal-stem-cells-into-endothelial-cells
#15
Sami G Almalki, Devendra K Agrawal
BACKGROUND: Cell-based therapy that can rejuvenate the endothelium with stimulated adipose-derived mesenchymal stem cells (AMSCs) is a promising therapeutic strategy for the re-endothelialization of denuded arteries at the stenting site. Previously, we have shown that silencing of MMP-2 and MMP-14 inhibits vascular endothelial growth factor receptor type 2 (VEGFR2) cleavage, and induces differentiation of AMSCs toward the endothelial cell (EC) lineage. In this study, we examined the underlying signaling pathways that regulate differentiation of AMSCs to ECs in vitro through VEGFR2...
May 12, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28498674/anisotropic-fe3o4-mn3o4-hybrid-nanocrystals-with-unique-magnetic-properties
#16
Maowei Jiang, Xiaogang Peng
This work explores novel nanomagnets by site- and facet-selective epitaxy of Mn3O4 nanodomains onto colloidal Fe3O4 nanoprisms in solution. At 190 °C, the Mn3O4 nanodomains epitaxially grow at three vertexes of the Fe3O4 nanoprisms in solution and form horns-on-prism hybrid nanocrystals. At 240 °C and in the same reaction solution, the epitaxy occurs on the top facet of the Fe3O4 nanoprisms, which results in prism-on-prism hybrid nanocrystals. As the temperature increases from 190 to 240 °C, the ratio between the prism-on-prism and horns-on-prism nanocrystals increases...
May 18, 2017: Nano Letters
https://www.readbyqxmd.com/read/28498576/a-critique-of-the-ultra-high-risk-and-transition-paradigm
#17
Jim van Os, Sinan Guloksuz
The transdiagnostic expression of psychotic experiences in common mental disorder (anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a small minority of people may indeed develop a clinical picture that meets criteria for schizophrenia. However, it appears neither useful nor valid to observe early states of multidimensional psychopathology in young people through the "schizo"-prism, and apply misleadingly simple, unnecessary and inefficient binary concepts of "risk" and "transition"...
June 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28497362/size-and-shape-dependent-cytotoxicity-profile-of-gold-nanoparticles-for-biomedical-applications
#18
Anna Woźniak, Anna Malankowska, Grzegorz Nowaczyk, Bartosz F Grześkowiak, Karol Tuśnio, Ryszard Słomski, Adriana Zaleska-Medynska, Stefan Jurga
Metallic nanoparticles, in particular gold nanoparticles (AuNPs), offer a wide spectrum of applications in biomedicine. A crucial issue is their cytotoxicity, which depends greatly on various factors, including morphology of nanoparticles. Because metallic nanoparticles have an effect on cell membrane integrity, their shape and size may affect the viability of cells, due to their different geometries as well as physical and chemical interactions with cell membranes. Variations in the size and shape of gold nanoparticles may indicate particular nanoparticle morphologies that provide strong cytotoxicity effects...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28496302/goldmann-tonometer-error-correcting-prism-clinical-evaluation
#19
Sean McCafferty, Garrett Lim, William Duncan, Eniko T Enikov, Jim Schwiegerling, Jason Levine, Corin Kew
PURPOSE: Clinically evaluate a modified applanating surface Goldmann tonometer prism designed to substantially negate errors due to patient variability in biomechanics. METHODS: A modified Goldmann prism with a correcting applanation tonometry surface (CATS) was mathematically optimized to minimize the intraocular pressure (IOP) measurement error due to patient variability in corneal thickness, stiffness, curvature, and tear film adhesion force. A comparative clinical study of 109 eyes measured IOP with CATS and Goldmann prisms...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28493691/surface-proton-transfer-promotes-four-electron-oxygen-reduction-on-gold-nanocrystal-surfaces-in-alkaline-solution
#20
Fang Lu, Yu Zhang, Shizhong Liu, Deyu Lu, Dong Su, Mingzhao Liu, Yugang Zhang, Ping Liu, Jia X Wang, Radoslav R Adzic, Oleg Gang
Four-electron oxygen reduction reaction (4e-ORR), a key pathway in energy conversion, is preferred over the two-electron reduction pathway that falls short in dissociating dioxygen molecules. Gold surfaces exhibit high sensitivity of the ORR pathway to its atomic structures. A long-standing puzzle remains unsolved: why the Au surfaces with {100} sub-facets were exceptionally capable to catalyze the 4e-ORR in alkaline solution, though limited within a narrow potential window. Herein we report the discovery of a dominant 4e-ORR over the whole potential range on {310} surface of Au nanocrystal shaped as truncated ditetragonal prism (TDP)...
May 19, 2017: Journal of the American Chemical Society
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