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https://www.readbyqxmd.com/read/29471434/disease-definition-for-schizophrenia-by-functional-connectivity-using-radiomics-strategy
#1
Long-Biao Cui, Lin Liu, Hua-Ning Wang, Liu-Xian Wang, Fan Guo, Yi-Bin Xi, Ting-Ting Liu, Chen Li, Ping Tian, Kang Liu, Wen-Jun Wu, Yi-Huan Chen, Wei Qin, Hong Yin
Specific biomarker reflecting neurobiological substrates of schizophrenia (SZ) is required for its diagnosis and treatment selection of SZ. Evidence from neuroimaging has implicated disrupted functional connectivity in the pathophysiology. We aimed to develop and validate a method of disease definition for SZ by resting-state functional connectivity using radiomics strategy. This study included 2 data sets collected with different scanners. A total of 108 first-episode SZ patients and 121 healthy controls (HCs) participated in the current study, among which 80% patients and HCs (n = 183) and 20% (n = 46) were selected for training and testing in intra-data set validation and 1 of the 2 data sets was selected for training and the other for testing in inter-data set validation, respectively...
February 17, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29471385/functional-neural-correlates-of-slower-gait-among-older-adults-with-mild-cognitive-impairment
#2
Chun Liang Hsu, John R Best, Michelle W Voss, Todd C Handy, Olivier Beauchet, Chris Lim, Teresa Liu-Ambrose
Background: Subtle, but observable, changes in mobility often exist among older adults with mild cognitive impairment (MCI). Notably, these changes are not inconsequential. Therefore, there is a strong interest to better understand the underlying neural correlates of gait slowing among older adults with MCI. In this study, we aimed to characterize patterns of functional connectivity associated with slower gait speed in older adults with MCI. Methods: 49 participants ≥ 60 years with MCI were included in the cross-sectional study...
February 17, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29471348/sexual-dimorphism-of-resting-state-network-connectivity-in-healthy-ageing
#3
Sharna D Jamadar, Francesco Sforazzini, Parnesh Raniga, Nicholas J Ferris, Bryan Paton, Michael J Bailey, Amy Brodtmann, Paul A Yates, Geoffrey A Donnan, Stephanie A Ward, Robyn L Woods, Elsdon Storey, John J McNeil, Gary F Egan
Objectives: The onset of many illnesses is confounded with age and sex. Increasing age is a risk factor for the development of many illnesses, and sexual dimorphism influences brain anatomy, function, and cognition. Here, we examine frequency-specific connectivity in resting-state networks in a large sample (n = 406) of healthy aged adults. Method: We quantify frequency-specific connectivity in three resting-state networks known to be implicated in age-related decline: the default mode, dorsal attention, and salience networks, using multiband functional magnetic resonance imaging...
February 17, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29471283/task-residual-functional-connectivity-of-language-and-attention-networks
#4
Stella M Tran, Keith M McGregor, George Andrew James, Kaundinya Gopinath, Venkatagiri Krishnamurthy, Lisa C Krishnamurthy, Bruce Crosson
Functional connectivity using task-residual data capitalizes on remaining variance after mean task-related signal is removed from a time series. The degree of network specificity in language and attention domains featured by task-residual and resting-state data types were compared. Functional connectivity based on task-residual data evidenced stronger laterality of the language and attention connections and thus greater network specificity compared to resting-state functional connectivity of the same connections...
February 19, 2018: Brain and Cognition
https://www.readbyqxmd.com/read/29471028/the-structural-and-functional-brain-networks-that-support-human-social-networks
#5
M P Noonan, R B Mars, J Sallet, R I M Dunbar, L K Fellows
Social skills rely on a specific set of cognitive processes, raising the possibility that individual differences in social networks are related to differences in specific brain structural and functional networks. Here, we tested this hypothesis with multimodality neuroimaging. With diffusion MRI (DMRI), we showed that differences in structural integrity of particular white matter (WM) tracts, including cingulum bundle, extreme capsule and arcuate fasciculus were associated with an individual's social network size (SNS)...
February 19, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29470996/default-mode-network-and-deep-gray-matter-analysis-in-neuromyelitis-optica-patients
#6
Fernanda C Rueda-Lopes, Fernanda M C Pessôa, Gustavo Tukamoto, Fabíola Rachid Malfetano, Simone Batista Scherpenhuijzen, Soniza Alves-Leon, Emerson L Gasparetto
OBJECTIVE: The aim of our study was to detect functional changes in default-mode network of neuromyelitis optica (NMO) patients using resting-state functional magnetic resonance images and the evaluation of subcortical grey-matter structures volumes. MATERIALS AND METHODS: NMO patients (n = 28) and controls patients (N=19) were enrolled. We used the integrated registration and segmentation tool, part of FMRIB's Software Library (FSL) to segment subcortical structures including the thalamus, caudate nucleus, putamen, hippocampus and amygdalae...
February 19, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29470965/causal-evidence-for-a-neural-component-of-spatially-global-hemodynamic-signals
#7
Kathrin Müsch, Christopher J Honey
In this issue of Neuron, Turchi et al. (2018) reversibly inactivate the basal forebrain to show that this region magnifies global neocortical signal fluctuations without altering the topography of canonical resting-state networks. Thus, spatially diffuse signals measurable via functional neuroimaging may track large-scale neuromodulatory state changes in the primate brain.
February 21, 2018: Neuron
https://www.readbyqxmd.com/read/29470691/even-effect-of-milk-protein-and-carbohydrate-intake-but-no-further-effect-of-heavy-resistance-exercise-on-myofibrillar-protein-synthesis-in-older-men
#8
Søren Reitelseder, Kasper Dideriksen, Jakob Agergaard, Nikolaj M Malmgaard-Clausen, Rasmus L Bechshoeft, Rasmus K Petersen, Anja Serena, Ulla R Mikkelsen, Lars Holm
PURPOSE: The responsiveness of older individuals' skeletal muscle to anabolic strategies may be impaired. However, direct comparisons within the same experimental setting are sparse. The aim of this study was to assess the resting and post-resistance exercise muscle protein synthesis rates in response to two types of milk protein and carbohydrate using a unilateral exercise leg model. METHODS: Twenty-seven older (69 ± 1 year, mean ± SE) men were randomly assigned one of three groups: Whey hydrolysate (WH), caseinate (CAS), or carbohydrate (CHO)...
February 22, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29470492/memory-functions-reveal-structural-properties-of-gene-regulatory-networks
#9
Edgar Herrera-Delgado, Ruben Perez-Carrasco, James Briscoe, Peter Sollich
Gene regulatory networks (GRNs) control cellular function and decision making during tissue development and homeostasis. Mathematical tools based on dynamical systems theory are often used to model these networks, but the size and complexity of these models mean that their behaviour is not always intuitive and the underlying mechanisms can be difficult to decipher. For this reason, methods that simplify and aid exploration of complex networks are necessary. To this end we develop a broadly applicable form of the Zwanzig-Mori projection...
February 22, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29470434/pharmacokinetics-and-scintigraphic-imaging-of-the-hypoxia-imaging-agent-123-i-iaza-in-healthy-adults-following-exercise-based-cardiac-stress-%C3%A2
#10
Daria Stypinski, Stephen A McQuarrie, Alexander J B McEwan, Leonard I Wiebe
The objective of this work is to evaluate the potential effect of cardiac stress exercise on the accumulation of [123 I]IAZA, a radiopharmaceutical used to image focal tissue hypoxia, in otherwise normal myocardium in healthy volunteers, and to determine the impact of exercise on [123 I]IAZA pharmacokinetics. The underlying goal is to establish a rational basis and a baseline for studies of focal myocardial hypoxia in cardiac patients using [123 I]IAZA. Three healthy male volunteers ran the 'Bruce' treadmill protocol, a clinically-accepted protocol designed to expose myocardial ischemia in patients...
February 22, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29468854/differential-effects-of-oxycodone-and-venlafaxine-on-resting-state-functional-connectivity-a-randomized-placebo-controlled-magnetic-resonance-imaging-study
#11
Tine M Hansen, Dina Lelic, Anne E Olesen, Asbjørn Mohr Drewes, Jens B Frøkjaer
AIM: Different mechanisms may be involved in the antinociceptive effects of oxycodone (opioid) and venlafaxine (serotonin-norepinephrine reuptake inhibitor), and the aim of this study was to investigate the effect of these drugs on brain functional connectivity. METHODS: Resting state functional magnetic resonance imaging was acquired in 20 healthy volunteers before and after a 5-day treatment with oxycodone, venlafaxine, or placebo in a randomized, double-blind, crossover study...
February 21, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29468083/research-note-a-resting-state-cerebello-amygdaloid-intrinsically-connected-network
#12
Christophe Habas
Background: Previous ROI-based functional connectivity studies found functional coherence between cerebellum and cerebral amygdale, at rest. Moreover, some neurospychiatric symptoms were accompanied by abnormal activations of these two brain areas. Therefore, the aim of the study was to identify a putative, resting-state intrinsically connected cerebello-amygdaloid network. Methods: ICA-based analysis was performed on brain resting-state functional images of 15 volunteers...
2018: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/29467790/classification-of-autism-spectrum-disorder-using-random-support-vector-machine-cluster
#13
Xia-An Bi, Yang Wang, Qing Shu, Qi Sun, Qian Xu
Autism spectrum disorder (ASD) is mainly reflected in the communication and language barriers, difficulties in social communication, and it is a kind of neurological developmental disorder. Most researches have used the machine learning method to classify patients and normal controls, among which support vector machines (SVM) are widely employed. But the classification accuracy of SVM is usually low, due to the usage of a single SVM as classifier. Thus, we used multiple SVMs to classify ASD patients and typical controls (TC)...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29467676/effect-of-heart-rate-on-basketball-three-point-shot-accuracy
#14
Luca P Ardigò, Goran Kuvacic, Antonio D Iacono, Giacomo Dascanio, Johnny Padulo
The three-point shot (3S) is a fundamental basketball skill used frequently during a game, and is often a main determinant of the final result. The aim of the study was to investigate the effect of different metabolic conditions, in terms of heart rates, on 3S accuracy (3S%) in 24 male (Under 17) basketball players (age 16.3 ± 0.6 yrs). 3S performance was specifically investigated at different heart rates. All sessions consisted of 10 consecutive 3Ss from five different significant field spots just beyond the FIBA three-point line, i...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29467646/age-dependent-modulations-of-resting-state-connectivity-following-motor-practice
#15
Elena Solesio-Jofre, Iseult A M Beets, Daniel G Woolley, Lisa Pauwels, Sima Chalavi, Dante Mantini, Stephan P Swinnen
Recent work in young adults has demonstrated that motor learning can modulate resting state functional connectivity. However, evidence for older adults is scarce. Here, we investigated whether learning a bimanual tracking task modulates resting state functional connectivity of both inter- and intra-hemispheric regions differentially in young and older individuals, and whether this has behavioral relevance. Both age groups learned a set of complex bimanual tracking task variants over a 2-week training period...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29467642/subcritical-hopf-bifurcation-and-stochastic-resonance-of-electrical-activities-in-neuron-under-electromagnetic-induction
#16
Yu-Xuan Fu, Yan-Mei Kang, Yong Xie
The FitzHugh-Nagumo model is improved to consider the effect of the electromagnetic induction on single neuron. On the basis of investigating the Hopf bifurcation behavior of the improved model, stochastic resonance in the stochastic version is captured near the bifurcation point. It is revealed that a weak harmonic oscillation in the electromagnetic disturbance can be amplified through stochastic resonance, and it is the cooperative effect of random transition between the resting state and the large amplitude oscillating state that results in the resonant phenomenon...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29467640/alterations-of-resting-state-static-and-dynamic-functional-connectivity-of-the-dorsolateral-prefrontal-cortex-in-subjects-with-internet-gaming-disorder
#17
Xu Han, Xiaowei Wu, Yao Wang, Yawen Sun, Weina Ding, Mengqiu Cao, Yasong Du, Fuchun Lin, Yan Zhou
Internet gaming disorder (IGD), a major behavior disorder, has gained increasing attention. Recent studies indicate altered resting-state static functional connectivity (FC) of the dorsolateral prefrontal cortex (DLPFC) in subjects with IGD. Whereas static FC often provides information on functional changes in subjects with IGD, investigations of temporal changes in FC between the DLPFC and the other brain regions may shed light on the dynamic characteristics of brain function associated with IGD. Thirty subjects with IGD and 30 healthy controls (HCs) matched for age, gender and education status were recruited...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29467636/increased-posterior-insula-sensorimotor-connectivity-is-associated-with-cognitive-function-in-healthy-participants-with-sleep-complaints
#18
Chun-Hong Liu, Cun-Zhi Liu, Xue-Qi Zhu, Ji-Liang Fang, Shun-Li Lu, Li-Rong Tang, Chuan-Yue Wang, Qing-Quan Liu
Insomnia is characterized by sensory hypersensitivity and cognitive impairments. Recent work has identified the insula as a central brain region involved in both bottom-up gating of sensory information and top-down cognitive control. However, the specific relationships between insular subregion connectivity and emotional and cognitive functions remain unclear. In this study, resting-state functional magnetic resonance imaging data were obtained from 25 healthy participants with sleep complaints (HPS) and 25 age-, gender- and educational level-matched healthy participants without insomnia complaints (HP)...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29467289/protonation-state-of-inhibitors-determines-interaction-sites-within-voltage-gated-sodium-channels
#19
Amanda Buyan, Delin Sun, Ben Corry
Voltage-gated sodium channels are essential for carrying electrical signals throughout the body, and mutations in these proteins are responsible for a variety of disorders, including epilepsy and pain syndromes. As such, they are the target of a number of drugs used for reducing pain or combatting arrhythmias and seizures. However, these drugs affect all sodium channel subtypes found in the body. Designing compounds to target select sodium channel subtypes will provide a new therapeutic pathway and would maximize treatment efficacy while minimizing side effects...
February 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29466802/healthy-and-pathological-brain-aging-from-the-perspective-of-oscillations-functional-connectivity-and-signal-complexity
#20
Ryouhei Ishii, Leonides Canuet, Yasunori Aoki, Masahiro Hata, Masao Iwase, Shunichiro Ikeda, Keiichiro Nishida, Manabu Ikeda
Healthy aging is associated with impairment in cognitive information processing. Several neuroimaging methods such as functional magnetic resonance imaging, positron emission tomography and near-infrared spectroscopy have been used to explore healthy and pathological aging by relying on hemodynamic or metabolic changes that occur in response to brain activity. Since electroencephalography (EEG) and magnetoencephalography (MEG) are able to measure neural activity directly with a high temporal resolution of milliseconds, these neurophysiological techniques are particularly important to investigate the dynamics of brain activity underlying neurocognitive aging...
February 21, 2018: Neuropsychobiology
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