keyword
MENU ▼
Read by QxMD icon Read
search

Resting state

keyword
https://www.readbyqxmd.com/read/28432486/cholesterol-as-a-modifying-agent-of-the-neurovascular-unit-structure-and-function-under-physiological-and-pathological-conditions
#1
REVIEW
Ewelina Czuba, Aleksandra Steliga, Grażyna Lietzau, Przemysław Kowiański
The brain, demanding constant level of cholesterol, precisely controls its synthesis and homeostasis. The brain cholesterol pool is almost completely separated from the rest of the body by the functional blood-brain barrier (BBB). Only a part of cholesterol pool can be exchanged with the blood circulation in the form of the oxysterol metabolites such, as 27-hydroxycholesterol (27-OHC) and 24S-hydroxycholesterol (24S-OHC). Not only neurons but also blood vessels and neuroglia, constituting neurovascular unit (NVU), are crucial for the brain cholesterol metabolism and undergo precise regulation by numerous modulators, metabolites and signal molecules...
April 21, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28432196/the-case-against-libertarian-arguments-for-compulsory-vaccination
#2
Justin Bernstein
In a recent paper in this journal, Jason Brennan correctly notes that libertarians struggle to justify a policy of compulsory vaccination. The most straightforward argument that justifies compulsory vaccination is that such a policy promotes welfare. But libertarians cannot make this argument because they claim that the state is justified only in protecting negative rights, not in promoting welfare. I consider two representative libertarian attempts to justify compulsory vaccination, and I argue that such arguments are unsuccessful...
April 21, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28431249/macrophages-facilitate-electrical-conduction-in-the-heart
#3
Maarten Hulsmans, Sebastian Clauss, Ling Xiao, Aaron D Aguirre, Kevin R King, Alan Hanley, William J Hucker, Eike M Wülfers, Gunnar Seemann, Gabriel Courties, Yoshiko Iwamoto, Yuan Sun, Andrej J Savol, Hendrik B Sager, Kory J Lavine, Gregory A Fishbein, Diane E Capen, Nicolas Da Silva, Lucile Miquerol, Hiroko Wakimoto, Christine E Seidman, Jonathan G Seidman, Ruslan I Sadreyev, Kamila Naxerova, Richard N Mitchell, Dennis Brown, Peter Libby, Ralph Weissleder, Filip K Swirski, Peter Kohl, Claudio Vinegoni, David J Milan, Patrick T Ellinor, Matthias Nahrendorf
Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with elongated macrophages expressing connexin 43. When coupled to spontaneously beating cardiomyocytes via connexin-43-containing gap junctions, cardiac macrophages have a negative resting membrane potential and depolarize in synchrony with cardiomyocytes. Conversely, macrophages render the resting membrane potential of cardiomyocytes more positive and, according to computational modeling, accelerate their repolarization...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28431177/altered-functional-connectivity-in-idiopathic-rapid-eye-movement-sleep-behavior-disorder-a-resting-state-eeg-study
#4
Jun-Sang Sunwoo, Sanghun Lee, Jung-Hoon Kim, Jung-Ah Lim, Tae-Joon Kim, Jung-Ick Byun, Min Hee Jeong, Kwang Su Cha, Jeong Woo Choi, Kyung Hwan Kim, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Kon Chu, Manho Kim, Sang Kun Lee, Ki-Young Jung
Study Objectives: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is considered as a prodromal stage of synucleinopathy. Although loss of functional connectivity is implicated in neurodegenerative diseases, network characteristics of electroencephalography (EEG) in iRBD are unknown. Therefore, we evaluated resting-state EEG functional connectivity to identify the brain network changes in patients with iRBD. Methods: We prospectively enrolled 20 patients with polysomnography-confirmed iRBD and 16 control subjects...
April 18, 2017: Sleep
https://www.readbyqxmd.com/read/28429774/synchronization-and-variability-imbalance-underlie-cognitive-impairment-in-primary-progressive-multiple-sclerosis
#5
Maria Petracca, Catarina Saiote, Heidi A Bender, Franchesca Arias, Colleen Farrell, Paola Magioncalda, Matteo Martino, Aaron Miller, Georg Northoff, Fred Lublin, Matilde Inglese
We aimed to investigate functional connectivity and variability across multiple frequency bands in brain networks underlying cognitive deficits in primary-progressive multiple sclerosis (PP-MS) and to explore how they are affected by the presence of cortical lesions (CLs). We analyzed functional connectivity and variability (measured as the standard deviation of BOLD signal amplitude) in resting state networks (RSNs) associated with cognitive deficits in different frequency bands in 25 PP-MS patients (12 M, mean age 50...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429383/altered-eigenvector-centrality-is-related-to-local-resting-state-network-functional-connectivity-in-patients-with-longstanding-type-1-diabetes-mellitus
#6
Eelco van Duinkerken, Menno M Schoonheim, Richard G IJzerman, Annette C Moll, Jesus Landeira-Fernandez, Martin Klein, Michaela Diamant, Frank J Snoek, Frederik Barkhof, Alle-Meije Wink
INTRODUCTION: Longstanding type 1 diabetes (T1DM) is associated with microangiopathy and poorer cognition. In the brain, T1DM is related to increased functional resting-state network (RSN) connectivity in patients without, which was decreased in patients with clinically evident microangiopathy. Subcortical structure seems affected in both patient groups. How these localized alterations affect the hierarchy of the functional network in T1DM is unknown. Eigenvector centrality mapping (ECM) and degree centrality are graph theoretical methods that allow determining the relative importance (ECM) and connectedness (degree centrality) of regions within the whole-brain network hierarchy...
April 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28429352/difference-in-resting-state-fractional-amplitude-of-low-frequency-fluctuation-between-bipolar-depression-and-unipolar-depression-patients
#7
H-L Yu, W-B Liu, T Wang, P-Y Huang, L-Y Jie, J-Z Sun, C Wang, W Qian, M Xuan, Q-Q Gu, H Liu, F-L Zhang, M-M Zhang
OBJECTIVE: To investigate the difference in fractional amplitude of low-frequency fluctuation (fALFF) of localized brain activities in the resting-state between bipolar depression and unipolar depression patients and to find biological markers that differentiate the two groups of patients. PATIENTS AND METHODS: Thirteen patients with bipolar depression, 15 patients with unipolar depression, and 16 healthy control subjects that were matched in age and years of education were subjected to 3...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429067/neuronal-oscillations-and-synchronicity-associated-with-gamma-hydroxybutyrate-during-resting-state-in-healthy-male-volunteers
#8
Robin von Rotz, Michael Kometer, Dario Dornbierer, Jürg Gertsch, M Salomé Gachet, Franz X Vollenweider, Erich Seifritz, Oliver G Bosch, Boris B Quednow
RATIONALE: Gamma-hydroxybutyrate (GHB) is a putative neurotransmitter, a drug of abuse, an anesthetic agent, and a treatment for neuropsychiatric disorders. In previous electroencephalography (EEG) studies, GHB was shown to induce an electrophysiological pattern of "paradoxical EEG-behavioral dissociation" characterized by increased delta and theta oscillations usually associated with sleep during awake states. However, no detailed source localization of these alterations and no connectivity analyses have been performed yet...
April 20, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28428748/resting-state-neuroimaging-and-neuropsychological-findings-in-opioid-use-disorder-during-abstinence-a-review
#9
REVIEW
Hada Fong-Ha Ieong, Zhen Yuan
Dependence to opiates, including illicit heroin and prescription pain killers, and treatment of the opioid use disorder (OUD) have been longstanding problems over the world. Despite intense efforts to scientific investigation and public health care, treatment outcomes have not significantly improved for the past 50 years. One reason behind the continuing use of heroin worldwide despite such efforts is its highly addictive nature. Brain imaging studies over the past two decades have made significant contribution to the understanding of the addictive properties as to be due in part to biological processes, specifically those in the brain structure and function...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28428208/resting-state-seed-based-analysis-an-alternative-to-task-based-language-fmri-and-its-laterality-index
#10
K A Smitha, K M Arun, P G Rajesh, B Thomas, C Kesavadas
BACKGROUND AND PURPOSE: Language is a cardinal function that makes human unique. Preservation of language function poses a great challenge for surgeons during resection. The aim of the study was to assess the efficacy of resting-state fMRI in the lateralization of language function in healthy subjects to permit its further testing in patients who are unable to perform task-based fMRI. MATERIALS AND METHODS: Eighteen healthy right-handed volunteers were prospectively evaluated with resting-state fMRI and task-based fMRI to assess language networks...
April 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28428146/the-correlation-between-mood-states-and-functional-connectivity-within-the-default-mode-network-can-differentiate-internet-gaming-disorder-from-healthy-controls
#11
Guangheng Dong, Hui Li, Lingxiao Wang, Marc N Potenza
The default-mode network (DMN) has been suggested to support a baseline state of brain activity. However, whether connectivity within the DMN is associated with mood states remains incompletely understood. The current study examined the correlation between mood state and the functional connectivity (FC) among DMN regions, and examined if the FC can differentiate Internet gaming disorder (IGD) from healthy controls (HC). Resting state data were collected within 108 college students (IGD,41; HC,67). Negative correlations were observed between measures of: (1) Depression and FCs among ventral DMN regions; (2) Anger and FCs among dorsal DMN regions; and, (3) Anger and Depression and FCs of both the ventral and dorsal DMN...
April 18, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28427027/multisensory-temporal-function-and-eeg-complexity-in-patients-with-epilepsy-and-psychogenic-nonepileptic-events
#12
Jean-Paul Noel, LeAnne Kurela, Sarah H Baum, Hong Yu, Joseph S Neimat, Martin J Gallagher, Mark Wallace
Cognitive and perceptual comorbidities frequently accompany epilepsy and psychogenic nonepileptic events (PNEE). However, and despite the fact that perceptual function is built upon a multisensory foundation, little knowledge exists concerning multisensory function in these populations. Here, we characterized facets of multisensory processing abilities in patients with epilepsy and PNEE, and probed the relationship between individual resting-state EEG complexity and these psychophysical measures in each patient...
April 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28425563/differences-in-interregional-brain-connectivity-in-children-with-unilateral-hearing-loss
#13
Matthew E Jung, Miranda Colletta, Rebecca Coalson, Bradley L Schlaggar, Judith E C Lieu
OBJECTIVES: To identify functional network architecture differences in the brains of children with unilateral hearing loss (UHL) using resting-state functional-connectivity magnetic resonance imaging (rs-fcMRI). STUDY DESIGN: Prospective observational study. METHODS: Children (7 to 17 years of age) with severe to profound hearing loss in one ear, along with their normal hearing (NH) siblings, were recruited and imaged using rs-fcMRI. Eleven children had right UHL; nine had left UHL; and 13 had normal hearing...
April 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28425500/structure-shapes-dynamics-and-directionality-in-diverse-brain-networks-mathematical-principles-and-empirical-confirmation-in-three-species
#14
Joon-Young Moon, Junhyeok Kim, Tae-Wook Ko, Minkyung Kim, Yasser Iturria-Medina, Jee-Hyun Choi, Joseph Lee, George A Mashour, UnCheol Lee
Identifying how spatially distributed information becomes integrated in the brain is essential to understanding higher cognitive functions. Previous computational and empirical studies suggest a significant influence of brain network structure on brain network function. However, there have been few analytical approaches to explain the role of network structure in shaping regional activities and directionality patterns. In this study, analytical methods are applied to a coupled oscillator model implemented in inhomogeneous networks...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424626/a-rat-immobilization-model-based-on-cage-volume-reduction-a-physiological-model-for-bed-rest
#15
Enrica Marmonti, Sílvia Busquets, Míriam Toledo, Marina Ricci, Marc Beltrà, Victòria Gudiño, Francesc Oliva, José M López-Pedrosa, Manuel Manzano, Ricardo Rueda, Francisco J López-Soriano, Josep M Argilés
Bed rest has been an established treatment in the past prescribed for critically illness or convalescing patients, in order to preserve their body metabolic resource, to prevent serious complications and to support their rapid path to recovery. However, it has been reported that prolonged bed rest can have detrimental consequences that may delay or prevent the recovery from clinical illness. In order to study disuse-induced changes in muscle and bone, as observed during prolonged bed rest in humans, an innovative new model of muscle disuse for rodents is presented...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28424611/modafinil-induced-changes-in-functional-connectivity-in-the-cortex-and-cerebellum-of-healthy-elderly-subjects
#16
Miriam Punzi, Tommaso Gili, Laura Petrosini, Carlo Caltagirone, Gianfranco Spalletta, Stefano L Sensi
In the past few years, cognitive enhancing drugs (CEDs) have gained growing interest and the focus of investigations aimed at exploring their use to potentiate the cognitive performances of healthy individuals. Most of this exploratory CED-related research has been performed on young adults. However, CEDs may also help to maintain optimal brain functioning or compensate for subtle and or subclinical deficits associated with brain aging or early-stage dementia. In this study, we assessed effects on resting state brain activity in a group of healthy elderly subjects undergoing acute administration of modafinil, a wakefulness-promoting agent...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28424575/contribution-of-autonomic-reflexes-to-the-hyperadrenergic-state-in-heart-failure
#17
REVIEW
Edgar Toschi-Dias, Maria Urbana P B Rondon, Chiara Cogliati, Nazareno Paolocci, Eleonora Tobaldini, Nicola Montano
Heart failure (HF) is a complex syndrome representing the clinical endpoint of many cardiovascular diseases of different etiology. Given its prevalence, incidence and social impact, a better understanding of HF pathophysiology is paramount to implement more effective anti-HF therapies. Based on left ventricle (LV) performance, HF is currently classified as follows: (1) with reduced ejection fraction (HFrEF); (2) with mid-range EF (HFmrEF); and (3) with preserved EF (HFpEF). A central tenet of HFrEF pathophysiology is adrenergic hyperactivity, featuring increased sympathetic nerve discharge and a progressive loss of rhythmical sympathetic oscillations...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28422388/comparison-of-the-effectiveness-of-two-different-interventions-to-reduce-preoperative-anxiety-a-randomized-controlled-study
#18
Nurcan Ertuğ, Özge Ulusoylu, Ayça Bal, Hazal Özgür
This study was conducted to determine and compare the effectiveness of nature sounds and relaxation exercises for reducing preoperative anxiety. A repeated measures randomized controlled trial design was used. We divided 159 preoperative patients into three groups: nature sounds (n = 53), relaxation exercises (n = 53), and control groups (n = 53). We evaluated anxiety using the visual analog scale and state anxiety inventory scores immediately before, immediately after, and 30 min after interventions in nature sounds and relaxation exercises groups, and silent rest in the control...
April 19, 2017: Nursing & Health Sciences
https://www.readbyqxmd.com/read/28422373/longitudinal-recovery-of-local-neuronal-activity-and-consciousness-level-in-acquired-brain-injury
#19
Qihong Zou, Xuehai Wu, Jin Hu, Weijun Tang, Ying Mao, Jianhong Zhu, Lu Lu, Yao Zhang, Jia-Hong Gao
Decreased brain activity in the default mode network, particularly in the precuneus (PCU), has been consistently shown in acquired brain injury (ABI) patients. However, it is unclear whether resting-state brain activity recovers longitudinally in ABI patients and whether functional activity restoration is associated with improvements in consciousness level. Here, resting-state fMRI data were acquired from 23 ABI patients and 30 age- and gender-matched controls with two longitudinal observations for each participant...
April 19, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28422138/abnormal-resting-state-functional-connectivity-in-the-orbitofrontal-cortex-of-heroin-users-and-its-relationship-with-anxiety-a-pilot-fnirs-study
#20
Hada Fong-Ha Ieong, Zhen Yuan
Drug addiction is widely linked to the orbitofrontal cortex (OFC), which is essential for regulating reward-related behaviors, emotional responses, and anxiety. Over the past two decades, neuroimaging has provided significant contributions revealing functional and structural alternations in the brains of drug addicts. However, the underlying neural mechanism in the OFC and its correlates with drug addiction and anxiety still require further elucidation. We first presented a pilot investigation to examine local networks in OFC regions through resting-state functional connectivity (rsFC) using functional near-infrared spectroscopy (fNIRS) from eight abstinent addicts in a heroin-dependent group (HD) and seven subjects in a control group (CG)...
April 19, 2017: Scientific Reports
keyword
keyword
9974
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"