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Subclinical hypothyroidism preterm

Aimee Seungdamrong
Subclinical hypothyroidism has been found to be associated with adverse reproductive outcomes, such as infertility, miscarriage, preterm birth, and complications of pregnancy. Multiple studies have investigated the relationships between thyroid function, thyroid antibodies, fertility, and pregnancy. Thyroid autoimmunity is the most common cause of hypothyroidism in iodine-sufficient locations. Thyroid antibodies have been associated with adverse reproductive outcomes such as miscarriage and infertility. Debate exists regarding the method of identification of thyroid dysfunction in pregnancy, which can be conducted by targeted screening or by universal screening...
October 14, 2016: Seminars in Reproductive Medicine
Nissim Arbib, Eran Hadar, Orly Sneh-Arbib, Rony Chen, Arnon Wiznitzer, Rinat Gabbay-Benziv
PURPOSE: Maternal thyroid gland dysfunction may adversely affect pregnancy outcome. We aimed to examine the association between subclinical thyroid dysfunction, both hypothyroidism and hyperthyroidism, to adverse pregnancy outcome. MATERIALS AND METHODS: Retrospective cohort study of all women with an available first trimester thyroid function testing and known pregnancy outcome, categorized to subclinical hypothyroidism, or hyperthyroidism and evaluated for complication during gestation and delivery...
October 17, 2016: Journal of Maternal-fetal & Neonatal Medicine
Paolo Cavarzere, Marta Camilot, Florina Ion Popa, Silvana Lauriola, Francesca Teofoli, Rossella Gaudino, Monica Vincenzi, Franco Antoniazzi
OBJECTIVE: To evaluate the incidence of congenital hypothyroidism (CH) with delayed TSH elevation among low-birth-weight (LBW) newborns in North-Eastern Italy and to verify if they need a second or third screening. DESIGN: Analysis of clinical and biochemical data of newborns affected by CH with delayed TSH elevation identified by neonatal screening. METHODS: Data of all newborns with birth weight (BW) <2500 g and evidence of delayed TSH elevation at newborn screening were collected between 2011 and 2014...
November 2016: European Journal of Endocrinology
Elizabeth V Arkema, Kristin Palmsten, Christopher Sjöwall, Elisabet Svenungsson, Jane E Salmon, Julia F Simard
OBJECTIVE: To assess maternal and fetal outcomes associated with subclinical (pre-systemic lupus erythematosus [SLE] and SLE presenting up to 5 years postpartum) and prevalent maternal SLE during pregnancy compared with the general population. METHODS: This prospective cohort study used population-based Swedish registers to identify 13,598 women with first singleton pregnancies registered in the Medical Birth Register (551 prevalent SLE, 65 pre-SLE within 0-2 years, 133 pre-SLE within 2-5 years, and 12,847 general population)...
July 2016: Arthritis Care & Research
Daniel I Nassie, Eran Ashwal, Oded Raban, Avi Ben-Haroush, Arnon Wiznitzer, Yariv Yogev, Amir Aviram
OBJECTIVE: To investigate the association between subclinical hypothyroidism and preterm contractions. METHODS: Prospective observational study among women at 23 + 0/7 and 34 + 6/7 weeks of gestation, with no known thyroid function abnormality, and preterm uterine contractions (PTC). All patients underwent laboratory evaluation of Thyroid Stimulating Hormone (TSH) and Free Thyroxin (FT4). Patients with and without PTC were compared. RESULTS: No association was found between PTC and sub-clinical hypothyroidism...
May 18, 2016: Journal of Maternal-fetal & Neonatal Medicine
Spyridoula Maraka, Naykky M Singh Ospina, Derek T O'Keeffe, Ana E Espinosa De Ycaza, Michael R Gionfriddo, Patricia J Erwin, Charles C Coddington, Marius N Stan, M Hassan Murad, Victor M Montori
BACKGROUND: The impact of subclinical hypothyroidism (SCH) and of levothyroxine replacement in pregnant women with SCH is unclear. The aims of this study were to assess (i) the impact of SCH during pregnancy on maternal and neonatal outcomes, and (ii) the effect of levothyroxine replacement therapy in these patients. METHODS: Ovid MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE, the Cochrane Controlled Trials Register, Ovid EMBASE, Web of Science, and Scopus were searched from inception to January 2015...
April 2016: Thyroid: Official Journal of the American Thyroid Association
N Johnson, A-K Taylor-Christmas, V Chatrani, E Choo-Kang, M Smikle, R Wright-Pascoe, K Phillips, M Reid
OBJECTIVE: Restoration of euthyroidism with l-thyroxine reportedly reduces obstetric complications associated with subclinical hypothyroidism (SCH). The objective was to determine if obstetric outcomes of treated subjects were equivalent to euthyroid subjects. METHODS: This was a prospective cohort study. Subjects were considered euthyroid if serum thyroid-stimulating hormone (TSH) was 0.4-3 mIU/L, free thyroxine (FT4) 10.29-17.05 pmol/L with negative TPO antibodies (TPOAb)...
May 11, 2015: West Indian Medical Journal
Sima Nazarpour, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Fereidoun Azizi
BACKGROUND: Pregnancy has a huge impact on the thyroid function in both healthy women and those that have thyroid dysfunction. The prevalence of thyroid dysfunction in pregnant women is relatively high. OBJECTIVE: The objective of this review was to increase awareness and to provide a review on adverse effect of thyroid dysfunction including hyperthyroidism, hypothyroidism and thyroid autoimmune positivity on pregnancy outcomes. MATERIALS AND METHODS: In this review, Medline, Embase and the Cochrane Library were searched with appropriate keywords for relevant English manuscript...
July 2015: Iranian Journal of Reproductive Medicine
Penelope M Sheehan, Alison Nankervis, Edward Araujo Júnior, Fabricio Da Silva Costa
CONTEXT: Thyroid disease in pregnancy is increasing with rising average maternal ages in developed countries. The evidence for an association between preterm birth and thyroid disease has been confounded by small studies with varying outcomes and methodology. OBJECTIVE: The aim of this meta-analysis is to review the literature regarding thyroid disease including subclinical and overt hypothyroidism, hyperthyroidism, and isolated hypothyroxinemia and the specific outcome of preterm birth...
November 2015: Journal of Clinical Endocrinology and Metabolism
Efser Oztas, Kudret Erkenekli, Sibel Ozler, Aynur Aktas, Umran Buyukkagnıcı, Dilek Uygur, Nuri Danisman
AIM: The aim of the present study is to compare pregnancy outcomes among patients with and without thyroid antibodies and/or subclinical hypothyroidism and investigate whether there is an association between first trimester maternal plasma interleukin-6 (IL-6) levels and adverse pregnancy outcomes. METHODS: A case-control study was carried out including 83 pregnant women (40 thyroid antibody positive and 43 healthy controls). The predictive value of first trimester maternal plasma IL-6 levels on adverse pregnancy outcomes were investigated...
November 2015: Journal of Obstetrics and Gynaecology Research
Forough Saki, Mohammad Hossein Dabbaghmanesh, Seyede Zahra Ghaemi, Sedighe Forouhari, Gholamhossein Ranjbar Omrani, Marzieh Bakhshayeshkaram
BACKGROUND: Maternal thyroid function alters during pregnancy. Inadequate adaptation to these changes results in thyroid dysfunction and pregnancy complications. OBJECTIVES: This prospective study aimed to evaluate the prevalence of thyroid diseases in pregnancy and its outcomes in south of Iran. MATERIALS AND METHODS: This prospective study was conducted on 600 healthy singleton pregnant women who aged 18 to 35 years old at 15 to 28 weeks of gestation...
October 2014: International Journal of Endocrinology and Metabolism
Yiping He, Tongqiang He, Yanxia Wang, Zhao Xu, Yehong Xu, Yiqing Wu, Jing Ji, Yang Mi
OBJECTIVE: To explore the effect of different diagnositic criteria of subclinical hypothyroidism using thyroid stimulating hormone (TSH) and positive thyroid peroxidase antibodies (TPO-Ab) on the pregnancy outcomes. METHODS: 3 244 pregnant women who had their antenatal care and delivered in Child and Maternity Health Hospital of Shannxi Province August from 2011 to February 2013 were recruited prospectively. According to the standard of American Thyroid Association (ATA), pregnant women with normal serum free thyroxine (FT4) whose serum TSH level> 2...
November 2014: Zhonghua Fu Chan Ke za Zhi
Shaowei Wang, Min Li, Defa Chu, Lin Liang, Xiaodong Zhao, Junrong Zhang
OBJECTIVE: To evaluate the relationship between clinical or subclinical hypothyroidism and positive thyroid autoantibody before 20 weeks pregnancy and risk of preterm birth. METHODS: Literature search was done in PubMed, EMBASE, Wanfang Medical Database, China Academic Journal Network Publishing Database and China Biology Medicine disc databases from January 1st, 1980 to December 31th, 2013. The following search terms were used:hypothyroidism, subclinical hypothyroidism, hypothyroxinnism, thyroid antibody, preterm labor, preterm birth, etc...
November 2014: Zhonghua Fu Chan Ke za Zhi
Pinar Kumru, Emre Erdogdu, Resul Arisoy, Oya Demirci, Aysen Ozkoral, Cem Ardic, Arif Aktug Ertekin, Sinan Erdogan, Nilufer Nihan Ozdemir
PURPOSE: The objective of this study was to assess the effect of thyroid dysfunction and autoimmunity in early pregnancy on adverse pregnancy and neonatal outcome. METHODS: 497 pregnant women between 10 and 12 gestational age were invited who were attending for their first antenatal visit and asked to perform blood tests for thyroid function and antithyroid peroxidase antibodies. A total of 395 women were recruited in the present study. Cases were classified into four groups according to thyroid function and anti-TPO results...
May 2015: Archives of Gynecology and Obstetrics
Roberto Negro, Alex Stagnaro-Green
In prospective studies, the prevalence of undiagnosed subclinical hypothyroidism in pregnant women ranges from 3% to 15%. Subclinical hypothyroidism is associated with multiple adverse outcomes in the mother and fetus, including spontaneous abortion, pre-eclampsia, gestational hypertension, gestational diabetes, preterm delivery, and decreased IQ in the offspring. Only two prospective studies have evaluated the impact of levothyroxine therapy in pregnant women with subclinical hypothyroidism, and the results were mixed...
October 6, 2014: BMJ: British Medical Journal
Brian Casey, Margarita de Veciana
The adverse impact of overt hypothyroidism that complicates pregnancy outcomes is well-established and not debated. For more than a decade, however, endocrinologists and obstetricians have been debating whether screening for subclinical thyroid disorders during pregnancy should be routine or should continue to be based on symptoms and risk factors. Several observational studies have suggested that offspring of women with asymptomatic thyroid dysfunction were at increased risk for impaired neurodevelopment. Other studies have suggested that pregnant women with subclinical thyroid disease, particularly those identified with an elevated thyroid-stimulating hormone (TSH) level may be at increased risk for pregnancy complications such as fetal death, preterm birth, or placental abruption...
October 2014: American Journal of Obstetrics and Gynecology
Sangita Nangia Ajmani, Deepa Aggarwal, Pushpa Bhatia, Manisha Sharma, Vinita Sarabhai, Mohini Paul
AIM: To determine the current prevalence of thyroid dysfunction in normal pregnant women and to study the impact of thyroid dysfunction on maternal and fetal outcome. METHODS: 400 pregnant women between 13 and 26 weeks of gestation were registered for the study. Apart from routine obstetrical investigations, TSH tests were done. Free T4 and anti-TPO antibody tests were done in patients with deranged TSH. Patients were followed up till delivery. Their obstetrical and perinatal outcomes were noted...
April 2014: Journal of Obstetrics and Gynaecology of India
Karen L Wilson, Brian M Casey, Donald D McIntire, F Gary Cunningham
OBJECTIVE: The aims were to establish a gestational-age specific curve for serum total thyroxine (T4) levels and to compare pregnancy outcomes of euthyroid women with those identified to have subclinical hypothyroidism (SCH) defined by an elevated thyroid-stimulating hormone (TSH) level in conjunction with either total T4 or free T4 determinations. STUDY DESIGN: Over a 2.5 year period, serum thyroid analytes were measured in all women presenting for prenatal care...
August 2014: American Journal of Obstetrics and Gynecology
Roberto Negro, Alex Stagnaro-Green
OBJECTIVE: To evaluate the peer-reviewed literature on hypothyroidism, hyperthyroidism, and thyroid autoimmunity in pregnancy. METHODS: We review published studies on thyroid autoimmunity and dysfunction in pregnancy, the impact of thyroid disease on pregnancy, and discuss implications for screening. RESULTS: Overt hyperthyroidism and hypothyroidism are responsible for adverse obstetric and neonatal events. Several studies of association suggest that either subclinical hypothyroidism or thyroid autoimmunity increase the risk of complications...
June 2014: Endocrine Practice
Kusum Lata, Pinaki Dutta, Subbiah Sridhar, Minakshi Rohilla, Anand Srinivasan, G R V Prashad, Viral N Shah, Anil Bhansali
OBJECTIVES: Thyroid antibody positivity during pregnancy has been associated with adverse outcomes including miscarriage and preterm delivery. The aim of the study is to evaluate the obstetric outcome in pregnant women with recurrent miscarriage and their response to levothyroxine (l-T4) therapy. STUDY DESIGN AND METHODS: All pregnant and non-pregnant women between 21 and 35 years of age with a history of two or more consecutive miscarriages were included in the study...
June 1, 2013: Endocrine Connections
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