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https://www.readbyqxmd.com/read/28335204/multifunctional-inorganic-nanoparticles-recent-progress-in-thermal-therapy-and-imaging
#1
REVIEW
Kondareddy Cherukula, Kamali Manickavasagam Lekshmi, Saji Uthaman, Kihyun Cho, Chong-Su Cho, In-Kyu Park
Nanotechnology has enabled the development of many alternative anti-cancer approaches, such as thermal therapies, which cause minimal damage to healthy cells. Current challenges in cancer treatment are the identification of the diseased area and its efficient treatment without generating many side effects. Image-guided therapies can be a useful tool to diagnose and treat the diseased tissue and they offer therapy and imaging using a single nanostructure. The present review mainly focuses on recent advances in the field of thermal therapy and imaging integrated with multifunctional inorganic nanoparticles...
April 18, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28303522/nanotechnology-for-the-treatment-of-melanoma-skin-cancer
#2
REVIEW
Lucas B Naves, Chetna Dhand, Jayarama Reddy Venugopal, Lakshminarayanan Rajamani, Seeram Ramakrishna, Luis Almeida
Melanoma is the most aggressive type of skin cancer and has very high rates of mortality. An early stage melanoma can be surgically removed, with a survival rate of 99%. This literature review intends to elucidate the possibilities to treat melanoma skin cancer using hybrid nanofibers developed by advanced electrospinning process. In this review we have shown that the enhanced permeability and retention is the basis for using nanotechnology, aiming topical drug delivery. The importance of the detection of skin cancer in the early stages is directly related to non-metastatic effects and survival rates of melanoma cells...
March 16, 2017: Progress in biomaterials
https://www.readbyqxmd.com/read/28296286/nanomedicine-approaches-to-improve-cancer-immunotherapy
#3
REVIEW
Hui Qiu, Yuanzeng Min, Zach Rodgers, Longzhen Zhang, Andrew Z Wang
Significant advances have been made in the field of cancer immunotherapy by orchestrating the body's immune system to eradicate cancer cells. However, safety and efficacy concerns stemming from the systemic delivery of immunomodulatory compounds limits cancer immunotherapies expansion and application. In this context, nanotechnology presents a number of advantages, such as targeted delivery to immune cells, enhanced clinical outcomes, and reduced adverse events, which may aid in the delivery of cancer vaccines and immunomodulatory agents...
March 10, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28294042/green-synthesized-nanomaterials-as-theranostic-platforms-for-cancer-treatment-principles-challenges-and-the-road-ahead
#4
Pala Rajasekharreddy, Chao Huang, Siddhardha Busi, Jobina Rajkumari, Ming-Hong Tai, Gang Liu
With the emergence of nanotechnology, new methods have been developed for engineering various nanoparticles for biomedical applications. Nanotheranostics is a burgeoning research field with tremendous prospects for the improvement of diagnosis and treatment of various cancers. However, the development of biocompatible and efficient drug/gene delivery theranostic systems still remains a challenge. Green synthetic approach of nanoparticles with low capital and operating expenses, reduced environmental pollution and better biocompatibility and stability is a latest and novel field, which is advantageous over chemical or physical nanoparticle synthesis methods...
March 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28292234/bovine-serum-albumin-as-a-versatile-platform-for-cancer-imaging-and-therapy
#5
Jun Wang, Bingbo Zhang
With the rapid development of nanotechnology, a large number of nanomaterials have been developed for cancer imaging and therapy. Among these nanomaterials, Bovine Serum Albumin (BSA) is attracting ever-increasing attention, due to biocompatibility, biodegradability, ease of availability and preparation, high drug loading efficiency and abundant number of functional groups. Currently, BSA-based nanoparticles are widely reported in the biomedical applications. This article reviews the applications of BSA as a versatile platform for cancer imaging and therapy, which includes BSA as drug carrier, surface modification agent and bio-mimetic template...
March 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28291372/spotlight-on-the-delivery-of-photosensitizers-different-approaches-for-photodynamic-based-therapies
#6
Diogo Silva Pellosi, Priscila da Costa Carvalho de Jesus, Antonio Claudio Tedesco
Nanomedicine development allowed the discovery of new photosensitizers (PS) and drug delivery systems (DDS) to overcome current issues on phototherapy. Nano-engineered materials have the potential to improve the solubility of PS, control drug pharmacokinetics, decreasing side effects, increasing bioavailability, and overcoming multidrug resistance. A recent approach is the co-delivery of PS with other therapeutic agents in a multimodal platform for synergic and improved results. Areas Covered: This paper discusses the delivery of PS-nanostructured platforms for conventional, photothermal, and antimicrobial photodynamic therapies, as well as in a recent therapeutic modality for photobiomodulation, covering applications of cancer diagnosis, targeting to skin pathogens, photoregeneration and wound healing...
March 14, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28291330/cancer-cell-specific-mitochondria-targeted-drug-delivery-by-dual-ligand-functionalized-nanodiamonds-circumvent-drug-resistance
#7
Miu Shan Chan, Ling Sum Liu, Hoi Man Leung, Pik Kwan Lo
We demonstrate a nanotechnology approach for the development of cancer-cell-specific subcellular organelle-targeted drug nanocarriers based on photostable nanodiamonds (ND) functionalized with folic acid and mitochondrial localizing sequence (MLS) peptides. We showed that these multifunctional NDs not only distinguish between cancer cells and normal cells, and transport the loaded drugs across the plasma membrane of cancer cells, but also selectively deliver them to mitochondria and induce significant cytotoxicity and cell death compared with free Dox localized in lysosomes...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28291324/nanosalina-a-tale-of-saline-loving-algae-from-the-lake-s-agony-to-cancer-therapy
#8
Fatemeh Ostadhossein, Santosh K Misra, Aaron Schwartz-Duval, Brajendra K Sharma, Dipanjan Pan
The nanoparticles (NPs) that contain the therapeutic agent within themselves without further modifications can be coined as 'self-therapeutic' NPs. The development of these agents especially when derived from natural resources can lead to a paradigm shift in the field of cancer nanotechnology as they can immensely facilitate the complex chemistry procedures and the follow up biological complications. Herein, we demonstrate that inherently therapeutic NPs 'integrating' β-carotene can be synthesized from Dunaliella Salina microalgae in a single step without complicated chemistry...
March 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28288893/redox-responsive-theranostic-nanoplatforms-based-on-inorganic-nanomaterials
#9
Lu Han, Xiao-Yong Zhang, Yu-Long Wang, Xi Li, Xiao-Hong Yang, Min Huang, Kun Hu, Lu-Hai Li, Yen Wei
Spurred on by advances in materials chemistry and nanotechnology, scientists have developed many novel nanopreparations for cancer diagnosis and therapy. To treat complex malignant tumors effectively, multifunctional nanomedicines with targeting ability, imaging properties and controlled drug release behavior should be designed and exploited. The therapeutic efficiency of loaded drugs can be dramatically improved using redox-responsive nanoplatforms which can sense the differences in the redox status of tumor tissues and healthy ones...
March 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28287321/curcumin-nanotechnologies-and-its-anticancer-activity
#10
Parasuraman Aiya Subramani, Kalpana Panati, Venkata Ramireddy Narala
Cancer is one of the leading causes of death worldwide. Curcumin is a well-established anticancer agent in vitro but its efficacy is yet to be proven in clinical trials. Poor bioavailability of curcumin is the principal reason behind the lack of efficiency of curcumin in clinical trials. Many studies prove that the bioavailability of curcumin can be improved by administering it through nanoparticle drug carriers. This review focuses on the efforts made in the field of nanotechnology to improve the bioavailability of curcumin...
April 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28287182/dna-conjugated-gold-nanoparticles-based-colorimetric-assay-to-assess-helicase-activity-a-novel-route-to-screen-potential-helicase-inhibitors
#11
Jashmini Deka, Aditya Mojumdar, Pietro Parisse, Silvia Onesti, Loredana Casalis
Helicase are essential enzymes which are widespread in all life-forms. Due to their central role in nucleic acid metabolism, they are emerging as important targets for anti-viral, antibacterial and anti-cancer drugs. The development of easy, cheap, fast and robust biochemical assays to measure helicase activity, overcoming the limitations of the current methods, is a pre-requisite for the discovery of helicase inhibitors through high-throughput screenings. We have developed a method which exploits the optical properties of DNA-conjugated gold nanoparticles (AuNP) and meets the required criteria...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28285944/combination-antitumor-therapy-with-targeted-dual-nanomedicines
#12
REVIEW
Wenbing Dai, Xiaoyou Wang, Ge Song, Tongzhou Liu, Bing He, Hua Zhang, Xueqing Wang, Qiang Zhang
Combination therapy is one of the important treatment strategies for cancer at present. However, the outcome of current combination therapy based on the co-administration of conventional dosage forms is suboptimal, due to the short half-lives of chemodrugs, their deficient tumor selectivity and so forth. Nanotechnology-based targeted delivery systems show great promise in addressing the associated problems and providing superior therapeutic benefits. In this review, we focus on the combination of therapeutic strategies between different nanomedicines or drug-loaded nanocarriers, rather than the co-delivery of different drugs via a single nanocarrier...
March 7, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28282891/multicomponent-tumor-homing-chitosan-nanoparticles-for-cancer-imaging-and-therapy
#13
REVIEW
Jaehong Key, Kyeongsoon Park
Current clinical methods for cancer diagnosis and therapy have limitations, although survival periods are increasing as medical technologies develop. In most cancer cases, patient survival is closely related to cancer stage. Late-stage cancer after metastasis is very challenging to cure because current surgical removal of cancer is not precise enough and significantly affects bystander normal tissues. Moreover, the subsequent chemotherapy and radiation therapy affect not only malignant tumors, but also healthy tissues...
March 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28267316/advances-toward-more-efficient-targeted-delivery-of-nanoparticles-in-vivo-understanding-interactions-between-nanoparticles-and-cells
#14
Ester Polo, Manuel Collado, Beatriz Pelaz, Pablo Del Pino
In this Perspective, we describe current challenges and recent advances in efficient delivery and targeting of nanoparticles in vivo. We discuss cancer therapy, nanoparticle-biomolecule interactions, nanoparticle trafficking in cells, and triggers and responses to nanoparticle-cell interactions. No matter which functionalization strategy to target cancer is chosen, passive or active targeting, more than 99% of the nanoparticles administered in vivo end up in the mononuclear phagocytic system, mainly sequestered by macrophages...
March 7, 2017: ACS Nano
https://www.readbyqxmd.com/read/28266269/liposomal-nanotechnology-for-cancer-theranostics
#15
Zhifei Dai, Xiuli Yue
Liposomes are a type of biomimetic nanoparticles generated from self-assembling concentric lipid bilayer enclosing an aqueous core domain. They have been attractive nanocarriers for the delivery of many drugs (e.g. radiopharmaceuticals, chemotherapeutic agents, porphyrin) and diagnostic agents (e.g. fluorescent dyes, quantum dots, Gadolinium complex and Fe3O4) by encapsulating (or adsorbing) hydrophilic one inside the liposomal aqueous core domain (or on the bilayer membrane surface), and by entrapping hydrophobic one within the liposomal bilayer...
March 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28263436/influence-of-designer-self-assembling-nanofiber-scaffolds-containing-anti-cancer-peptide-motif-on-hepatoma-carcinoma-cells
#16
Ting Liu, Pindong Li, Honglin Jin, Qian Ding, Zhenwei Zou, Gang Peng
Nanotechnology provides a novel scope for cancer therapeutics. Nanoscale platforms could influence the survival, adhesion and migration of cancer cells through altering the tumor microenvironments. We report here the development of an anti-tumor material designed specifically for cancer therapy. We synthesized a 48-amino acid peptide RADA-KLA, which could self-assemble into nanostructures with antitumor activities. We tested the microstructure of RADA-KLA nanofiber scaffold using transmission electron microscopy (TEM) and accessed rheological properties of the material...
March 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28261325/technical-advances-in-global-dna-methylation-analysis-in-human-cancers
#17
REVIEW
Basudev Chowdhury, Il-Hoon Cho, Joseph Irudayaraj
Prototypical abnormalities of genome-wide DNA methylation constitute the most widely investigated epigenetic mechanism in human cancers. Errors in the cellular machinery to faithfully replicate the global 5-methylcytosine (5mC) patterns, commonly observed during tumorigenesis, give rise to misregulated biological pathways beneficial to the rapidly propagating tumor mass but deleterious to the healthy tissues of the affected individual. A growing body of evidence suggests that the global DNA methylation levels could serve as utilitarian biomarkers in certain cancer types...
2017: Journal of Biological Engineering
https://www.readbyqxmd.com/read/28255364/leukocyte-mediated-delivery-of-nanotherapeutics-in-inflammatory-and-tumor-sites
#18
REVIEW
Xinyue Dong, Dafeng Chu, Zhenjia Wang
Nanotechnology has become a powerful tool to potentially translate nanomedicine from bench to bedside. Nanotherapeutics are nanoparticles (NPs) loaded with drugs and possess the property of tissue targeting after surfaces of NPs are bio-functionalized. Designing smaller size of nanotherapeutics is presumed to increase tumor targeting based on the EPR (enhanced permeability and retention) effect. Since the immune systems possess a defence mechanism to fight diseases, there is an emerging concept that NPs selectively target immune cells to mediate the active delivery of drugs into sites of disease...
2017: Theranostics
https://www.readbyqxmd.com/read/28252638/multifunctional-biocompatible-chitosan-polypyrrole-nanocomposites-as-novel-agents-for-photoacoustic-imaging-guided-photothermal-ablation-of-cancer
#19
Panchanathan Manivasagan, Nhat Quang Bui, Subramaniyan Bharathiraja, Madhappan Santha Moorthy, Yun-Ok Oh, Kyeongeun Song, Hansu Seo, Min Yoon, Junghwan Oh
Cancer nanotechnology is emerging as one of the promising strategies combining photothermal therapy (PTT) and photoacoustic imaging (PAI) for the treatment of breast cancer and it has received considerable attention in the recent years because it is minimally invasive, prevents damage to non-targeted regions, permits fast recovery, and involves breast cancer imaging. The present study demonstrates multifunctional biocompatible chitosan-polypyrrole nanocomposites (CS-PPy NCs) as novel agents for photoacoustic imaging-guided photothermal ablation of cancer because of their biocompatibility, conductivity, stability, and strong near-infrared (NIR) absorbance...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28250648/the-influence-of-pluronic-f68-and-f127-nanocarrier-on-physicochemical-properties-in-vitro-release-and-antiproliferative-activity-of-thymoquinone-drug
#20
Salwa Shaarani, Shahrul Sahul Hamid, Noor Haida Mohd Kaus
BACKGROUND: This study reports on hydrophobic drug thymoquinone (TQ), an active compound found in the volatile oil of Nigella sativa that exhibits anticancer activities. Nanoformulation of this drug could potentially increase its bioavailability to specific target cells. OBJECTIVE: The aim of this study was to formulate TQ into polymer micelle, Pluronic F127 (5.0 wt %) and Pluronic F68 (0.1 wt %), as a drug carrier to enhance its solubility and instability in aqueous media...
January 2017: Pharmacognosy Research
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