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https://www.readbyqxmd.com/read/28808212/recent-advances-in-arsenic-trioxide-encapsulated-nanoparticles-as-drug-delivery-agents-to-solid-cancers
#1
Anam Akhtar, Scarlet Xiaoyan Wang, Lucy Ghali, Celia Bell, Xuesong Wen
Since arsenic trioxide was first approved as the front line therapy for acute promyelocytic leukemia 25 years ago, its anti-cancer properties for various malignancies have been under intense investigation. However, the clinical successes of arsenic trioxide in treating hematological cancers have not been translated to solid cancers. This is due to arsenic's rapid clearance by the body's immune system before reaching the tumor site. Several attempts have henceforth been made to increase its bioavailability toward solid cancers without increasing its dosage albeit without much success...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28806615/graphene-gold-based-nanocomposites-applications-in-cancer-diseases-efficient-detection-and-therapeutic-tools
#2
REVIEW
Lina A Al-Ani, Mohammed A AlSaadi, Farkaad A Kadir, Najihah M Hashim, Nurhidayatullaili M Julkapli, Wageeh A Yehye
Early detection and efficient treatment of cancer disease remains a drastic challenge in 21st century. Throughout the bulk of funds, studies, and current therapeutics, cancer seems to aggressively advance with drug resistance strains and recurrence rates. Nevertheless, nanotechnologies have indeed given hope to be the next generation for oncology applications. According to US National cancer institute, it is anticipated to revolutionize the perspectives of cancer diagnosis and therapy. With such success, nano-hybrid strategy creates a marvelous preference...
July 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28803721/conditioning-neoadjuvant-therapies-for-improved-immunotherapy-of-cancer
#3
REVIEW
Zachary Benson, Saeed H Manjili, Mehran Habibi, Georgi Guruli, Amir A Toor, Kyle K Payne, Masoud H Manjili
Recent advances in the treatment of melanoma and non-small cell lung cancer (NSCLC) by combining conventional therapies with anti-PD1/PD-L1 immunotherapies, have renewed interests in immunotherapy of cancer. The emerging concept of conventional cancer therapies combined with immunotherapy differs from the classical concept in that it is not simply taking advantage of their additive anti-tumor effects, but it is to use certain therapeutic regimens to condition the tumor microenvironment for optimal response to immunotherapy...
August 10, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28799495/a-nanotechnology-based-strategy-to-increase-the-efficiency-of-cancer-diagnosis-and-therapy-folate-conjugated-gold-nanoparticles
#4
Jaber Beik, Sara Khademi, Neda Attaran, Saeed Sarkar, Ali Shakeri-Zadeh, Habib Ghaznavi, Hossein Ghadiri
BACKGROUND: Gold nanoparticle (AuNP), owing to its elegant physicochemical properties, has been recently introduced as a promising theranostic nanoparticle. Folic acid is a necessary vitamin for cell proliferation and cancer cells highly require such an essential molecule to be replicated. Accordingly, surface functionalization of AuNP with folic acid may offer great potentials for development of a new nanotechnology based strategy to increase the efficiency of cancer diagnosis and therapy...
August 10, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28795273/capacity-of-gold-nanoparticles-in-cancer-radiotherapy
#5
REVIEW
Nadeem M S Nagi, Yasir A M Khair, Ahmed M E Abdalla
Radiotherapy is the ionizing radiation used for treatment of cancer and other diseases. Although radiotherapy is the major treatment for cancer, a lot of patients do not undergo radiation due to associated risks such as radiation pneumonitis, cardiovascular complications, development of secondary tumor, and lymphedema. However, the advantages of nanotechnology provide a unique potential to enhance radiotherapeutic performance, in particular by utilizing gold nanoparticles (Au NPs). In this review, we briefly describe the current direction of research towards the use of Au NPs for radiotherapeutic enhancement, combination, monitoring and in side effect reductions...
August 9, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28780932/cancer-nanomedicine-lessons-for-immuno-oncology
#6
REVIEW
Shiladitya Sengupta
Cancer nanotechnology and cancer immunotherapy are two parallel themes that have emerged over the last few decades in the search for a cure for cancer. Exciting applications can emerge at the intersection of these two fields. However, it is important to learn from the past successes and failures of cancer nanomedicines for its future applications in cancer immunotherapy. This review discusses the two key parameters that defined clinical success in the case of cancer nanomedicines: (i) physicochemical design principles, and (ii) clinical trial design, which are frequently overlooked in most analyses of the state of the field...
August 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28776971/correction-to-cancer-nanoscience-and-nanotechnology-approaches
#7
Warren C W Chan, Ali Khademhosseini, Wolfgang J Parak, Paul S Weiss
No abstract text is available yet for this article.
August 4, 2017: ACS Nano
https://www.readbyqxmd.com/read/28772434/supercritical-co%C3%A2-assisted-spray-drying-of-strawberry-like-gold-coated-magnetite-nanocomposites-in-chitosan-powders-for-inhalation
#8
Marta C Silva, Ana Sofia Silva, Javier Fernandez-Lodeiro, Teresa Casimiro, Carlos Lodeiro, Ana Aguiar-Ricardo
Lung cancer is one of the leading causes of death worldwide. Therefore, it is of extreme importance to develop new systems that can deliver anticancer drugs into the site of action when initiating a treatment. Recently, the use of nanotechnology and particle engineering has enabled the development of new drug delivery platforms for pulmonary delivery. In this work, POXylated strawberry-like gold-coated magnetite nanocomposites and ibuprofen (IBP) were encapsulated into a chitosan matrix using Supercritical Assisted Spray Drying (SASD)...
January 18, 2017: Materials
https://www.readbyqxmd.com/read/28770623/angiogenesis-inhibitors-in-early-development-for-gastric-cancer
#9
Mauricio P Pinto, Gareth I Owen, Ignacio Retamal, Marcelo Garrido
Angiogenesis, or the generation of new blood vessels from pre-existent ones is a critical process for tumor growth and progression. Hence, the development of angiogenesis inhibitors with therapeutic potential has been a central focus for researchers. Most angiogenesis inhibitors target the Vascular Endothelial Growth Factor (VEGF) pathway, however a number of tyrosine kinase inhibitors (TKIs), immunomodulatory drugs (IMiDs) and inhibitors of the mammalian Target-Of-Rapamycin (mTOR) pathway also display antiangiogenic activity...
August 3, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28755883/metformin-insights-into-its-anticancer-potential-with-special-reference-to-ampk-dependent-and-independent-pathways
#10
REVIEW
Shoeb Ikhlas, Masood Ahmad
Metformin has been known for its antidiabetic effects for decades and is used as a first line therapy in type 2 diabetes. But recently its anticancer potential has also been discovered. Metformin targets many pathways that play an important role in cancer cell proliferation and angiogenesis, mTORC1 signaling is a crucial pathway among them. Metformin inhibits mTORC1 via AMPK dependent and AMPK independent pathways, thereby inhibiting cancer cell growth and development. Encouraged by positive results of numerous preclinical studies on various types of cancer, many clinical trials are underway to study metformin's effect in chemoprevention and treatment of cancers in humans...
July 26, 2017: Life Sciences
https://www.readbyqxmd.com/read/28752708/-advances-in-nanoparticle-targeting-tumor-associated-macrophages-for-cancer-imaging-and-therapy
#11
Guo Fengliang, Tang Guping, H U Qinglian
Tumor tissues are composed of tumor cells and complicate microenvironment. Tumor associated macrophages (TAMs) as an important component in tumor microenvironment, play fundamental roles in tumor progression, metastasis and microenvironment regulation. Recently, studies have found that nanotechnology, as an emerging platform, provides unique potential for cancer imaging and therapy. With the nanotechnology, TAMs imaging presents direct evidence for cancer development, progression, and the effectiveness of cancer treatments; it also can regulate the immunosuppression of tumor microenvironment and improve therapeutic efficiency through TAMs targeted killing or phenotypic transformation...
March 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28746057/solid-lipid-nanoparticles-improve-octyl-gallate-antimetastatic-activity-and-ameliorate-its-renal-and-hepatic-toxic-effects
#12
Clarissa A S Cordova, Claudriana Locatelli, Evelyn Winter, Adny H Silva, Betina G Zanetti-Ramos, Raquel Jasper, Alessandra Mascarello, Rosendo A Yunes, Ricardo J Nunes, Tânia B Creczynski-Pasa
Metastasis is the main cause of cancer-related death and requires the development of effective treatments with reduced toxicity and effective anticancer activity. Gallic acid derivatives have shown significant biological properties including antitumoral activity as shown in a previous study with octyl gallate (G8) in vitro. Thus, the aim of this work was to evaluate the antimetastatic effect of free and solid lipid nanoparticle-loaded G8 in mice in a lung metastasis model. Animals inoculated with melanoma cells presented metastasis in lungs, which was significantly inhibited by treatment with G8 and solid lipid nanoparticle-loaded G8, named G8-NVM...
July 25, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28745363/novel-nanosensing-technologies-for-exosome-detection-and-profiling
#13
REVIEW
Hyungsoon Im, Kyungheon Lee, Ralph Weissleder, Hakho Lee, Cesar M Castro
Exosomes have recently emerged as highly promising cancer biomarkers because they are abundant in biofluids, carry proteins and RNA reflecting their originating cells and are stable over weeks. Beyond abundance and stability, detailed exosome analyses could be clinically useful for diagnosing and profiling cancers. Despite their clinical potential, simple, reliable and sensitive approaches for rapidly quantifying exosomes and their molecular information has been challenging. Therefore, there is a clear need to develop next-generation sensing technologies for exosome detection and analysis...
July 26, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28745122/cell-membrane-derived-nanoparticles-emerging-clinical-opportunities-for-targeted-drug-delivery
#14
Svetlana T Yurkin, Zhenjia Wang
Biofunctionalization of nanoparticles (NPs) is an essential component in targeted drug delivery. However, current nanotechnology remains inadequate to imitate complex intercellular interactions existing in physiological conditions in human bodies. Emerging concepts have been explored to utilize human cells to generate cell membrane-formed NPs because cells retain inherent abilities to interact with human tissues compared with synthetic nanomaterials. Neutrophils, red blood cells (RBCs), platelets and monocytes have been employed to form therapeutic NPs to treat vascular disease and cancer, and these novel drug delivery platforms show the translation potential to improve patient quality of life...
August 2017: Nanomedicine
https://www.readbyqxmd.com/read/28743635/molecular-imaging-in-drug-development-update-and-challenges-for-radiolabeled-antibodies-and-nanotechnology
#15
REVIEW
Ilaria Colombo, Marta Overchuk, Juan Chen, Raymond M Reilly, Gang Zheng, Stephanie Lheureux
Despite the significant advancement achieved in understanding the molecular mechanisms responsible for cancer transformation and aberrant proliferation, leading to novel targeted cancer therapies, significant effort is still needed to "personalize" cancer treatment. Molecular imaging is an emerging field that has shown the ability to characterize in vivo the molecular pathways present at the cancer cell level, enabling diagnosis and personalized treatment of malignancies. These technologies, particularly SPECT and PET also permit the development of novel radiotheranostic probes, which provide capabilities for diagnosis and treatment with the same agent...
July 22, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28741923/co-delivery-of-trichosanthin-and-albendazole-by-nano-self-assembly-for-overcoming-tumor-multidrug-resistance-and-metastasis
#16
Yisi Tang, Jianming Liang, Aihua Wu, Yingzhi Chen, Pengfei Zhao, Tingting Lin, Meng Zhang, Qin Xu, Jianxin Wang, Yongzhuo Huang
Multidrug resistance (MDR) and metastasis are the major obstacles in cancer chemotherapy. Nanotechnology-based combination therapy is a useful strategy. Recently, the combination of biologics and small drugs has attracted much attention in cancer therapy. Yet, the treatment outcomes are often compromised by the different pharmacokinetic profiles of the co-administered drugs thus leading to inconsistent drug uptake and suboptimal drug combination at the tumor sites. Nanotechnology-based co-delivery offers a promising method to address this problem, which is well demonstrated in the use of small drug combinations...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28730451/using-planar-phi29-prna-three-way-junction-to-control-size-and-shape-of-rna-nanoparticles-for-biodistribution-profiling-in-mice
#17
Farzin Haque, Congcong Xu, Daniel L Jasinski, Hui Li, Peixuan Guo
RNA is rapidly emerging as a versatile building block for nanoparticle assembly due to its simplicity in base pairing, while exhibiting diversity in function such as enzymatic activity similar to some proteins. Recent advances in RNA nanotechnology have generated significant interests in applying RNA nanoparticles for various applications in nanotechnology and nanomedicine. In particular, assessing the effect of size and shape on cell entry and intracellular trafficking as well as in vivo biodistribution of nanoparticles is challenging due to the lack of nanoparticles rich in structure while varying in size and shape...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28723615/nanoformulations-of-curcumin-an-emerging-paradigm-for-improved-remedial-application
#18
REVIEW
Meeta Gera, Neelesh Sharma, Mrinmoy Ghosh, Do Luong Huynh, Sung Jin Lee, Taesun Min, Taeho Kwon, Dong Kee Jeong
Curcumin is a natural polyphenol and essential curcuminoid derived from the rhizome of the medicinal plant Curcuma longa (L.) is universally acknowledged as "Wonder drug of life". It is a vital consumable and restorative herb, commonly keened for several ailments such as cancer, arthritis, pain, bruises, gastrointestinal quandaries, swelling and much more. Despite its enormous curative potential, the poor aqueous solubility and consequently, minimal systemic bioavailability with rapid degradation are some of the major factors which restrict the utilization of curcumin at medical perspective...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722430/multi-amplified-sensing-of-microrna-by-a-small-dna-fragment-driven-enzymatic-cascade-reaction
#19
Eunjung Kim, Philip D Howes, Spencer W Crowder, Molly M Stevens
Combining technological developments such as nanomaterials, DNA nanotechnology, and functional enzymes has great potential to facilitate next generation high performance molecular diagnostic systems. In this work, we describe a microRNA (miRNA) detection assay that combines target recycling and isothermal amplification in an elegantly designed enzyme-mediated cascade reaction. Target recycling is driven by the action of duplex-specific nuclease (DSN), resulting in highly amplified translation of input miRNA to short output DNA fragments...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28721037/future-trends-and-emerging-issues-for-nanodelivery-systems-in-oral-and-oropharyngeal-cancer
#20
REVIEW
Alexandra Iulia Irimie, Laura Sonea, Ancuta Jurj, Nikolay Mehterov, Alina Andreea Zimta, Liviuta Budisan, Cornelia Braicu, Ioana Berindan-Neagoe
Oral cancer is a prevalent cancer type on a global scale, whose traditional treatment strategies have several drawbacks that could in the near future be overcome through the development of novel therapeutic and prognostic strategies. Nanotechnology provides an alternative to traditional therapy that leads to enhanced efficiency and less toxicity. Various nanosystems have been developed for the treatment of oral cancer, including polymeric, metallic, and lipid-based formulations that incorporate chemotherapeutics, natural compounds, siRNA, or other molecules...
2017: International Journal of Nanomedicine
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