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https://www.readbyqxmd.com/read/28534355/in-vitro-antiproliferative-effects-of-nab-paclitaxel-with-liposomal-cisplatin-on-mda-mb-231-and-mcf-7-breast-cancer-cell-lines
#1
Idil Cetin, Mehmet R Topcul
PURPOSE: In this study, the in vitro cytotoxic effect of nanotechnological drugs nab-paclitaxel and liposomal cisplatin combination was evaluated on MDA-MB-231 and MCF-7 breast cancer cell lines. METHODS: For this purpose cell viability, cell index values obtained from xCELLigence RTCA (Real-Time Cell Analysis) DP instrument, mitotic index (MI), apoptotic index (AI) and labelling index (LI) analysis among cell kinetic parameters were used. A1L25: 1 μg/ml nab-paclitaxel+25 μg/ml liposomal cisplatin, A1L5: 1 μg/ml nab-paclitaxel+5 μg/ml liposomal cisplatin and A10L5: 10 μg/ml nab-paclitaxel+5 μg/ml liposomal cisplatin for MDA-MB-231 cell line and A1L5: 1 μg/ml nab-paclitaxel+5 μg/ml liposomal cisplatin, A1L10: 1 μg/ml nab-paclitaxel+10 μg/ml liposomal cisplatin and A5L1: 5 μg/ml nab-paclitaxel+1 μg/ml liposomal cisplatin doses for MCF-7 were applied for 24-72 hrs...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28521696/nanotechnology-as-a-promising-strategy-for-anticancer-drug-delivery
#2
Mona Basha
Cancer was and still a very stressful and urgent disease condition representing a leading cause of death in developed as well as developing countries. Although, much research work in both medical and pharmaceutical fields has evolved in the past few years in addition to some promising clinical trials and few market products, cancer becomes much wilder, threatening and getting more lives. Most approaches have focused on the synthesis of new active ingredients or chemical modification of available ones, formulating them in suitable dosage forms aiming for targeted and effective drug delivery with minimal side effects...
May 15, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28521675/chemotherapy-with-si-rna-and-anti-cancer-drugs
#3
Kamaljeet Kaur, Goutam Rath, Saket Chandra, Ranjit Singh, Amit K Goyal
To treat cancer, chemotherapy is a key therapeutic approach which is associated with several limitations. This chemotherapeutical agents exhibit multi drug resistance coupled with undesirable side effects. This multidrug resistance is exhibited by tumor cell due to actuation of drug out flow mechanism, programmed cell death and protection mechanisms etc. One of the therapeutic approaches to cure cancer is RNA interference (RNAi). Small interfering RNA (si-RNA) is considered as a major therapeutic tool used to control expression of a particular gene...
May 18, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28511988/exploring-the-potential-of-nanotherapeutics-in-targeting-tumor-microenvironment-for-cancer-therapy
#4
REVIEW
Eameema Muntimadugu, Nagavendra Kommineni, Wahid Khan
Advanced research in the field of cancer biology clearly demonstrated the key role of tumor microenvironment (TME) in cancer development and metastasis particularly in solid tumors. Components of TME, being non-neoplastic in nature provide supportive and permissive conditions for the growth of cancer cells. Hence it is important to modify TME in cancer therapy and this would be achieved by better understanding of TME morphological features and functioning of stromal components. Nanotechnology based drug delivery offers various advantages such as prolonged circulation time, delivery of cargo at desired site, improved bioavailability, reduced toxicity etc...
May 13, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28505442/nitric-oxide-donor-based-cancer-therapy-advances-and-prospects
#5
Zhangjian Huang, Junjie Fu, Yihua Zhang
The increasing understanding of the role of nitric oxide (NO) in cancer biology has generated significant progress in the use of NO donor-based therapy to fight cancer. These advances strongly suggest the potential adoption of NO donor-based therapy in clinical practice, and this has been supported by several clinical studies in the past decade. In this review, we first highlight several types of important NO donors, including recently developed NO donors bearing a dinitroazetidine skeleton, represented by RRx-001, with potential utility in cancer therapy...
May 23, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28501439/paclitaxel-what-has-been-done-and-the-challenges-remain-ahead
#6
REVIEW
Ezequiel Bernabeu, Maximiliano Cagel, Eduardo Lagomarsino, Marcela Moretton, Diego A Chiappetta
In recent years, the nanotechnology has offered researchers the opportunity to solve the problems caused by the vehicle of the standard and first formulation of paclitaxel (Taxol(®)), while maximizing the proven antineoplastic activity of the drug against many solid tumors. Hence, different types of nanocarriers have been employed to improve the efficacy, safety, physicochemical properties and pharmacokinetic/pharmacodynamic profile of this drug. To date, paclitaxel is the unique drug that is marketed in three different nanoplatforms for its parenteral delivery: polymeric nanoparticles (Abraxane(®)), liposomes (Lipusu(®)), and polymeric micelles (Genexol(®), Nanoxel(®) and Paclical(®))...
May 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28494852/atomic-force-microscopy-correlates-antimetastatic-potentials-of-hepg2-cell-line-with-its-redox-energy-status-effects-of-curcumin-and-khaya-senegalensis
#7
Jeremiah Olorunjuwon Olugbami, Robert Damoiseaux, Bryan France, Michael A Gbadegesin, Adam Z Stieg, Shivani Sharma, Oyeronke A Odunola, James K Gimzewski
OBJECTIVE: The fatality of cancer is mostly dependent on the possibility of occurrence of metastasis. Thus, if the development of metastasis can be prevented through novel therapeutic strategies targeted against this process, then the success of cancer treatment will drastically increase. In this study, therefore, we evaluated the antimetastatic potentials of an extract of Khaya senegalensis and curcumin on the metastatic liver cell line HepG2, and also assessed the anticancer property of the extract...
May 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28488883/ultrasensitive-bioanalysis-current-status-and-future-trends
#8
Stéphanie Simon, Eric Ezan
Ligand-binding techniques such as immunoassays, the reference for clinical diagnosis, offer a wide range of innovative approaches based on signal DNA amplification, nanotechnologies or digital assays, which result in technologies with sensitivities more than 1000-times that of formats used 20 years ago. Providing that these technologies gain acceptance and translate into robust commercial platforms, we expect that several fields will be impacted in the near future, including the clinical diagnosis of cancer markers, the early detection of infectious diseases and the safety of biotherapeutics...
May 10, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28487069/development-of-nanomaterials-for-bone-targeted-drug-delivery
#9
REVIEW
Hao Cheng, Aditya Chawla, Yafeng Yang, Yuxiao Li, Jin Zhang, Hae Lin Jang, Ali Khademhosseini
Bone is one of the major organs of the human body; it supports and protects other organs, produces blood cells, stores minerals, and regulates hormones. Therefore, disorders in bone can cause serious morbidity, complications, or mortality of patients. However, despite the significant occurrence of bone diseases, such as osteoarthritis (OA), osteoporosis (OP), non-union bone defects, bone cancer, and myeloma-related bone disease, their effective treatments remain a challenge. In this review, we highlight recent progress in the development of nanotechnology-based drug delivery for bone treatment, based on its improved delivery efficiency and safety...
May 6, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28485601/hyaluronan-inorganic-nanohybrid-materials-for-biomedical-applications
#10
Zhixiang Cai, Hongbin Zhang, Yue Wei, Fengsong Cong
Nanomaterials, including gold, silver and magnetic nanoparticles, carbon and mesoporous materials, possess unique physiochemical and biological properties thus offering promising applications in biomedicine, such as in drug delivery, biosensing, molecular imaging and therapy. Recent advances in nanotechnology have improved the features and properties of nanomaterials. However, these nanomaterials are potentially cytotoxic and demonstrate lack of cell-specific function. Thus, they have been functionalized with various polymers, especially polysaccharides, to reduce toxicity, improve biocompatibility and stability under physiological conditions...
May 9, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28482783/nano-phytosome-a-developing-platform-for-herbal-anti-cancer-agents-in-cancer-therapy
#11
Afshin Babazadeh, Mahdi Zeinali, Hamed Hamishehkar
Cancer is one of the main cause of death in the world and remains a major challenge for current chemotherapy that has not yet been cured in an efficient manner. Nanotechnology opened a pioneer field in cancer therapy by modifying significant properties of drugs and their carriers. Nanotechnology utilizes various nanostructures to transport anti-cancer agents to the interest site of action. The greater stability of nanophytosomes is due to formation of a chemical links between phospholipid molecules and phytoactive agents...
May 7, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28480874/emerging-applications-of-nanotechnology-for-diagnosis-and-therapy-of-disease-a-review
#12
Richard H Bayford, Tom Rademacher, Ivan Roitt, Scarlet Wang
Nanotechnology is of increasing interest in the fields of medicine and physiology over recent years. Its application could considerably improve disease detection and therapy, and although the potential is considerable, there are still many challenges, which need to be addressed before it is accepted in routine clinical use. This review focuses on emerging applications that nanotechnology could enhance or provide new approaches in diagnoses and therapy. The main focus of recent research centres on targeted therapies and enhancing imaging; however, the introduction of nanomaterial into the human body must be controlled, as there are many issues with possible toxicity and long-term effects...
May 8, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28471199/-zinc-modified-nanotransporter-for-target-drug-therapy-of-breast-cancer
#13
S Skaličková, M Gargulák, M Löffelmann, B Ruttkay-Nedecký, M Kepinská, T Parák, R Kizek
BACKGROUND: In the centre of nanomedical interest stands the nanotechnological modification of anthracycline antibiotics, which are often used in antitumor treatment of hematological malignancies and solid tumors. Chitosan nanoparticles are gaining more attention in the field of targeted transport of drugs because of their stability, low toxicity and simple preparation. The main objective of the project, was the design of chitosan nanotransporter of anthracycline antibiotics with zinc modified surface, for a specific interaction with metallothionein...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28468256/magnetic-hyperthermia-and-oxidative-damage-to-dna-of-human-hepatocarcinoma-cells
#14
Filippo Cellai, Armelle Munnia, Jessica Viti, Saer Doumett, Costanza Ravagli, Elisabetta Ceni, Tommaso Mello, Simone Polvani, Roger W Giese, Giovanni Baldi, Andrea Galli, Marco E M Peluso
Nanotechnology is addressing major urgent needs for cancer treatment. We conducted a study to compare the frequency of 3-(2-deoxy-β-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M₁dG) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) adducts, biomarkers of oxidative stress and/or lipid peroxidation, on human hepatocarcinoma HepG2 cells exposed to increasing levels of Fe₃O₄-nanoparticles (NPs) versus untreated cells at different lengths of incubations, and in the presence of increasing exposures to an alternating magnetic field (AMF) of 186 kHz using (32)P-postlabeling...
April 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28465075/carbon-nanotube-capsules-enhance-the-in-vivo-efficacy-of-cisplatin
#15
Adem Guven, Gabriel J Villares, Susan G Hilsenbeck, Alaina Lewis, John D Landua, Lacey E Dobrolecki, Lon J Wilson, Michael T Lewis
Over the past few years, numerous nanotechnology-based drug delivery systems have been developed in an effort to maximize therapeutic effectiveness of conventional drug delivery, while limiting undesirable side effects. Among these, carbon nanotubes (CNTs) are of special interest as potential drug delivery agents due to their numerous unique and advantageous physical and chemical properties. Here, we show in vivo favorable biodistribution and enhanced therapeutic efficacy of cisplatin (CDDP) encapsulated within ultra-short single-walled carbon nanotube capsules (CDDP@US-tubes) using three different human breast cancer xenograft models...
April 29, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28457175/tissue-engineering-and-regenerative-medicine-new-trends-and-directions-a-year-in-review
#16
Manuela E Gomes, Márcia T Rodrigues, Rui M A Domingues, Rui L Reis
Tissue Engineering (TE) is continuously evolving assimilating inputs from adjacent scientific areas and their technological advances, including nanotechnology developments that have been spawning the range of available options for the precise manipulation and control of cells and cellular environments. Simultaneously, with the maturation of the field, TE is having a growing and marked impact in other fields, such as cancer and other diseases research, enabling tri-dimensional (3D) tumor/tissue models of increased complexity that more closely resemble living tissue dynamics, playing a decisive role in the development of new and improved therapies...
April 29, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28440368/mangiferin-functionalized-radioactive-gold-nanoparticles-mgf-198-aunps-in-prostate-tumor-therapy-green-nanotechnology-for-production-in-vivo-tumor-retention-and-evaluation-of-therapeutic-efficacy
#17
A Y Al-Yasiri, M Khoobchandani, C S Cutler, L Watkinson, T Carmack, C J Smith, M Kuchuk, S K Loyalka, A B Lugão, K V Katti
We report here an innovative feature of green nanotechnology-focused work showing that mangiferin-a glucose functionalized xanthonoid, found in abundance in mango peels-serves dual roles of chemical reduction and in situ encapsulation, to produce gold nanoparticles with optimum in vivo stability and tumor specific characteristics. The interaction of mangiferin with a Au-198 gold precursor affords MGF-(198)AuNPs as the beta emissions of Au-198 provide unique advantages for tumor therapy while gamma rays are used for the quantitative estimation of gold within the tumors and various organs...
April 25, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28440202/oral-nano-delivery-systems-for-colon-targeting-therapy
#18
Tianxu Zhang, Guanyin Zhu, Boyao Lu, Qiang Peng
Targeting drug delivery is an attractive research area, as it enables localized treatment, improves the efficacy of therapeutics and reduces systemic toxicity. Colon targeting delivery is particularly beneficial to the treatment of colon diseases, such as inflammatory bowel disease and colon cancer, due to the improved local drug concentrations. The traditional strategies for colon targeting delivery include time-dependent and pH-dependent technologies, etc. In recent years, nanotechnology has emerged as a novel and efficient tool for targeting drug delivery...
April 24, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28436961/the-evolving-landscape-of-drug-products-containing-nanomaterials-in-the-united-states
#19
Sheetal R D'Mello, Celia N Cruz, Mei-Ling Chen, Mamta Kapoor, Sau L Lee, Katherine M Tyner
The Center for Drug Evaluation and Research (CDER) within the US Food and Drug Administration (FDA) is tracking the use of nanotechnology in drug products by building and interrogating a technical profile of products containing nanomaterials submitted to CDER. In this Analysis, data from more than 350 products show an increase in the submissions of drug products containing nanomaterials over the last two decades. Of these, 65% are investigational new drugs, 17% are new drug applications and 18% are abbreviated new drug applications, with the largest class of products being liposomal formulations intended for cancer treatments...
April 24, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28434891/nanotechnology-based-therapeutic-modality-to-boost-anti-tumor-immunity-and-collapse-tumor-defense
#20
REVIEW
Xiaomeng Hu, Tingting Wu, Yuling Bao, Zhiping Zhang
Cancer is still the leading cause of death. While traditional treatments such as surgery, chemotherapy and radiotherapy play dominating roles, recent breakthroughs in cancer immunotherapy indicate that the influence of immune system on cancer development is virtually beyond our expectation. Manipulating the immune system to fight against cancer has been thriving in recent years. Further understanding of tumor anatomy provides opportunities to put a brake on immunosuppression by overcoming tumor intrinsic resistance or modulating tumor microenvironment...
April 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
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