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https://www.readbyqxmd.com/read/28918263/dna-nanotechnology-based-composite-type-gold-nanoparticle-immunostimulatory-dna-hydrogel-for-tumor-photothermal-immunotherapy
#1
Tomoya Yata, Yuki Takahashi, Mengmeng Tan, Hirotaka Nakatsuji, Shozo Ohtsuki, Tatsuya Murakami, Hiroshi Imahori, Yuka Umeki, Tomoki Shiomi, Yoshinobu Takakura, Makiya Nishikawa
Success of tumor photothermal immunotherapy requires a system that induces heat stress in cancer cells and enhances strong anti-tumor immune responses. Here, we designed a composite-type immunostimulatory DNA hydrogel consisting of a hexapod-like structured DNA (hexapodna) with CpG sequences and gold nanoparticles. Mixing of the properly designed hexapodna and oligodeoxynucleotide-modified gold nanoparticles resulted in the formation of composite-type gold nanoparticle-DNA hydrogels. Laser irradiation of the hydrogel resulted in the release of hexapodna, which efficiently stimulated immune cells to release proinflammatory cytokines...
September 9, 2017: Biomaterials
https://www.readbyqxmd.com/read/28914553/nanomaterials-as-nanocarriers-a-critical-assessment-why-these-are-multi-chore-vanquisher-in-breast-cancer-treatment
#2
Sania Naz, Hira Shahzad, Attarad Ali, Muhammad Zia
Breast cancer is a group of diseases with various subtypes and leads to high mortality throughout the globe. Various conventional techniques are in practice to cure breast cancer but these techniques are linked with various shortcomings. Mostly these treatments are not site directed and cause toxicity towards normal cells. In order to overcome these issues, we need smart system that can deliver anticancer drugs to specific sites. Targeted drug delivery can be achieved via passive or active drug delivery using nanocarriers...
September 15, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28911309/formulation-quality-control-and-safety-issues-of-nanocarriers-used-for-cancer-treatment
#3
Ismael D Bianco, Marcelo R Ceballos, Cristian Casado, Viviana G Dabbene, Carolina Rizzi, R Kiyomi Mizutamari
Cancer is becoming a leading cause of death in the last years. Although we have seen great advances, most human cancers remain incurable because many patients either do not respond or relapse to treatment. Several lines of research are disclosing new therapeutic targets which lead to new active drugs. However, there are still unsolved problems related to stabilization of the pharmaceutical ingredient in aqueous and biological media, pharmacokinetic and pharmacodynamic profiles and cellular uptake to name just a few...
June 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28911307/tumor-targeting-of-polymeric-nanoparticles-conjugated-with-peptides-saccharides-and-small-molecules-for-anticancer-drugs
#4
Banu Bayram, Aykut Özgür, Lütfi Tutar, Yusuf Tutar
Targeting drugs or pharmaceutical compounds to tumor site increases cancer treatment efficiency and therapeutic outcome. Nanoparticles are unique delivery systems for site-targeting within an organism. Many novel technologies have been established in drug research and development area. Nanotechnology now offers nanometer size polymeric nanoparticles and these particles direct drugs to their targets, protect drugs against degradation, and release the drug in a controlled manner. Modification of nanoparticle surface by molecules leads to prolonged retention and accumulation in the target area of the organism...
June 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28903185/mixed-micelles-for-encapsulation-of-doxorubicin-with-enhanced-in-vitro-cytotoxicity-on-breast-and-ovarian-cancer-cell-lines-versus-doxil-%C3%A2
#5
Maximiliano Cagel, Ezequiel Bernabeu, Lorena Gonzalez, Eduardo Lagomarsino, Marcela Zubillaga, Marcela A Moretton, Diego A Chiappetta
Doxorubicin (DOX) is used as a "first-line" antineoplastic drug in ovarian and metastatic breast cancer. However, serious side effects, such as cardiotoxicity have been reported after DOX intravenous administration. Hence, we investigated different micelle-former biomaterials, as Soluplus(®), Pluronic F127, Tetronic T1107 and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) to develop a potential mixed micellar nanocarrier for DOX delivery. Since DOX hydrochloride is a poor candidate to be encapsulated inside the hydrophobic core of the mixed micelles, we assayed a hydrophobic complex between DOX and sodium deoxycholate (NaDC) as an excellent candidate to be encapsulated within polymeric micelles...
September 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28901846/applications-of-nanoflowers-in-biomedicine
#6
Hossein Heli, Masoud Negahdary
BACKGROUND: Nanotechnology has opened new windows for biomedical researches and treatment of diseases. Nanostructures with flower-like shapes (nanoflowers) which have exclusive morphology and properties have been interesting for many researchers. METHODS: In this review, various applications of nanoflowers in biomedical researches and patents from various aspects have been investigated and reviewed. RESULTS: Nanoflowers attracted serious attentions in whole of biomedical fields such as cardiovascular diseases, microbiology, sensors and biosensors, biochemical and cellular studies, cancer therapy, healthcare and etc...
September 11, 2017: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/28898759/cuprous-oxide-nanoparticles-trigger-er-stress-induced-apoptosis-by-regulating-copper-trafficking-and-overcoming-resistance-to-sunitinib-therapy-in-renal-cancer
#7
Qiwei Yang, Ye Wang, Qing Yang, Yi Gao, Xiaopeng Duan, Qingcheng Fu, Chuanmin Chu, Xiuwu Pan, Xingang Cui, Yinghao Sun
While the current standard first-line treatment for advanced renal cell carcinoma (RCC) is sunitinib, patients inevitably develop resistance to this drug. However, the rapid development of nanotechnology has provided emerging techniques for the treatment of advanced tumours, including RCC. In our previous research, cuprous oxide nanoparticles (CONPs) showed ideal anti-tumour effects and low systemic toxicity. While many inorganic nanomedicines, including CONPs, have similar pharmacological effects, their detailed mechanisms remain unknown...
September 5, 2017: Biomaterials
https://www.readbyqxmd.com/read/28893628/a-combination-of-nanosystems-for-the-delivery-of-cancer-chemoimmunotherapeutic-combinations-1-methyltryptophan-nanocrystals-and-paclitaxel-nanoparticles
#8
P Calleja, J M Irache, C Zandueta, C Martínez-Oharriz, S Espuelas
IDO is an enzyme that tumors use to create a state of immunosupression. 1-D-methyltryptophan (1-MT) is an IDO pathway inhibitor. After being successfully evaluated in preclinical studies, current clinical trials are actually analyzing its efficacy as monotherapy or in combination with multiple chemotherapeutic agents such as paclitaxel. 1-MT very poor solubility in water and many other solvents precludes its ease parenteral administration. It is currently administered by oral route because high daily doses were well-tolerated and effectively inhibited the IDO activity although only 25% of dose was recovered in plasma...
September 8, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28892296/tailored-approaches-in-drug-development-and-diagnostics-from-molecular-design-to-biological-model-systems
#9
REVIEW
Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A Salminen, Diana Toivola, Daniel Abankwa, Ari Rosling, Didem Şen Karaman, Outi M H Salo-Ahen, Ronald Österbacka, John E Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm, Niklas Sandler
Approaches to increase the efficiency in developing drugs and diagnostics tools, including new drug delivery and diagnostic technologies, are needed for improved diagnosis and treatment of major diseases and health problems such as cancer, inflammatory diseases, chronic wounds, and antibiotic resistance. Development within several areas of research ranging from computational sciences, material sciences, bioengineering to biomedical sciences and bioimaging is needed to realize innovative drug development and diagnostic (DDD) approaches...
September 11, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28884039/nanotechnology-based-combination-therapy-for-overcoming-multidrug-resistant-cancer
#10
Meng Zhang, Ergang Liu, Yanna Cui, Yongzhuo Huang
Multidrug resistance (MDR) is a major obstacle to successful cancer treatment and is crucial to cancer metastasis and relapse. Combination therapy is an effective strategy for overcoming MDR. However, the different pharmacokinetic (PK) profiles of combined drugs often undermine the combination effect in vivo, especially when greatly different physicochemical properties (e.g., those of macromolecules and small drugs) combine. To address this issue, nanotechnology-based codelivery techniques have been actively explored...
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28883730/drug-delivery-approaches-for-breast-cancer
#11
REVIEW
Santosh Kumar Singh, Shriti Singh, James W Lillard, Rajesh Singh
Breast cancer is one of the most common cancers affecting women worldwide. The controlled release of drugs to the precise site of the disease using a nanocarrier vehicle increases the therapeutic efficiency of the drugs. Nanotechnology-based approaches used to endorse clinical improvement from a disease also help to understand the interaction of malignant cells with their microenvironment. Receptor-based targeting is another approach for drug delivery which is undergoing clinical trials. Nanoparticles (NPs) delivery has been proven to promise high loading capacity, less toxicity, and stability of the drugs or biomolecules compared to traditional chemotherapeutic drugs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28883725/gold-nanoparticles-enlighten-the-future-of-cancer-theranostics
#12
REVIEW
Jianfeng Guo, Kamil Rahme, Yan He, Lin-Lin Li, Justin D Holmes, Caitriona M O'Driscoll
Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed "theranostics," multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28883396/in-vivo-quantitative-imaging-of-tumor-ph-by-nanosonophore-assisted-multispectral-photoacoustic-imaging
#13
Janggun Jo, Chang H Lee, Raoul Kopelman, Xueding Wang
Changes of physiological pH are correlated with several pathologies, therefore the development of more effective medical pH imaging methods is of paramount importance. Here, we report on an in vivo pH mapping nanotechnology. This subsurface chemical imaging is based on tumor-targeted, pH sensing nanoprobes and multi-wavelength photoacoustic imaging (PAI). The nanotechnology consists of an optical pH indicator, SNARF-5F, 5-(and-6)-Carboxylic Acid, encapsulated into polyacrylamide nanoparticles with surface modification for tumor targeting...
September 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/28880679/application-of-nanocarrier-based-drug-delivery-system-in-treatment-of-oral-cancer
#14
Abhishek K Sah, Amber Vyas, Preeti K Suresh, Bina Gidwani
Oral cancer includes cancer of lips, oral cavity and oropharynx. Oral cancer is the sixth most life-threatening disease affecting 65% of population. The delivery of cytotoxic chemotherapeutic anticancer drugs is a challenging task due to unfavorable properties. Both synthetic chemotherapeutic agents and herbal constituents are used in treatment of oral cancer. The purpose of present article is to overcome the limitations through concept of nanotechnology and conjugation approach. Also, it will provide better therapeutic effect and sustain long life of healthy and recovered cells...
September 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28876902/amino-acid-functionalised-inorganic-nanoparticles-as-cutting-edge-therapeutic-and-diagnostic-agents
#15
Amlan Chakraborty, Jennifer Carla Boer, Cordelia Selomulya, Magdalena Plebanski
The field of medical diagnostics and therapeutics is being revolutionized by nanotechnology, from targeted drug delivery to cancer immunotherapy. Inorganic nanoparticles are widely used, albeit problems with agglutination, cytotoxicity, free radical generation and instability in some biological environments, limits their utility. Conjugation of biomolecules such as peptides to the surface of nanoparticles can mitigate such problems, as well as confer specialized theranostic (therapeutic and/or diagnostic) properties, useful across biomedical applications such as vaccines, drug delivery and in vivo imaging...
September 6, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28875848/polymeric-nanocarriers-a-new-horizon-for-the-effective-management-of-breast-cancer
#16
Iliyas Khan, Hitesh Kumar, Gaurav Mishra, Avinash Gothwal, Prashant Kesharwani, Umesh Gupta
BACKGROUND: Delivery of chemotherapeutic drugs for the diagnosis and treatment of cancer is becoming advanced day by day. However, the challenge of the effective delivery system still does exist. In various types of cancers, breast cancer is the most commonly diagnosed cancer among women. Breast cancer is a combination of different diseases. It cannot be considered as only one entity because there are many specific patient factors, which are involved in the development of this disease...
August 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28875844/the-clinical-translation-of-organic-nanomaterials-for-cancer-therapy-a-focus-on-polymeric-nanoparticles-micelles-liposomes-and-exosomes
#17
Stefano Palazzolo, Samer Bayda, Mohamad Hadla, Isabella Caligiuri, Giuseppe Corona, Giuseppe Toffoli, Flavio Rizzolio
The application of nanotechnology in the medical field is called nanomedicine. Nowadays, this new branch of science is a point of interest for many investigators due to the important advances in which we assisted in the lasts decades, in particular for cancer treatment. Cancer nanomedicine has been applied in different fields such as drug delivery, nanoformulation and nanoanalytical contrast reagents. The application of nanotechnology to pharmaceutical science allowed to build up nanosystems based on at least two stage vectors (drug/nanomaterial), which often shown a better pharmacokinetics (PK), bioavailability and biodistribution...
August 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28868980/nanoparticle-based-strategies-for-cancer-immunotherapy-and-immunodiagnostics
#18
Anna Maria Grimaldi, Mariarosaria Incoronato, Marco Salvatore, Andrea Soricelli
Although recent successes in clinical trials are strengthening research focused on cancer immunology, the poor immunogenicity and off-target side effects of immunotherapeutics remain major challenges in translating these promising approaches to clinically feasible therapies in the treatment of a large range of tumors. Nanotechnology offers target-based approaches, which have shown significant improvements in the rapidly advancing field of cancer immunotherapy. Here, we first discuss the chemical and physical features of nanoparticulate systems that can be tuned to address the anticancer immune response, and then review recent, key examples of the exploited strategies, ranging from nanovaccines to NPs revising the tumor immunosuppressive microenvironment, up to immunotherapeutic multimodal NPs...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28868970/the-use-of-nanoparticulates-to-treat-breast-cancer
#19
Xiaomeng Tang, Welley S Loc, Cheng Dong, Gail L Matters, Peter J Butler, Mark Kester, Craig Meyers, Yixing Jiang, James H Adair
Breast cancer is a major ongoing public health issue among women in both developing and developed countries. Significant progress has been made to improve the breast cancer treatment in the past decades. However, the current clinical approaches are invasive, of low specificity and can generate severe side effects. As a rapidly developing field, nanotechnology brings promising opportunities to human cancer diagnosis and treatment. The use of nanoparticulate-based platforms overcomes biological barriers and allows prolonged blood circulation time, simultaneous tumor targeting and enhanced accumulation of drugs in tumors...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28866224/highlights-in-nanocarriers-for-the-treatment-against-cervical-cancer
#20
REVIEW
Kaila P Medina-Alarcón, Aline R Voltan, Bruno Fonseca-Santos, Isabela Jacob Moro, Felipe de Oliveira Souza, Marlus Chorilli, Christiane Pienna Soares, André Gonzaga Dos Santos, Maria J S Mendes-Giannini, Ana M Fusco-Almeida
Cervical cancer is the second most common malignant tumor in women worldwide and has a high mortality rate, especially when it is associated with human papillomavirus (HPV). In US, an estimated 12,820 cases of invasive cervical cancer and an estimated 4210 deaths from this cancer will occur in 2017. With rare and very aggressive conventional treatments, one sees in the real need of new alternatives of therapy as the delivery of chemotherapeutic agents by nanocarriers using nanotechnology. This review covers different drug delivery systems applied in the treatment of cervical cancer, such as solid lipid nanoparticles (SNLs), liposomes, nanoemulsions and polymeric nanoparticles (PNPs)...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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