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https://www.readbyqxmd.com/read/28303752/bone-morphogenetic-proteins-and-dickkopf-1-in-ankylosing-spondylitis
#1
H-T Liao, Y-F Lin, C-Y Tsai, T-C Chou
OBJECTIVES: To determine bone morphogenetic proteins (BMPs) and Dickkopf homologue-1 (Dkk-1) levels in ankylosing spondylitis (AS). METHOD: Serum BMPs and Dkk-1 were measured in 72 AS patients and 30 healthy controls. For AS patients, we recorded the demographic data, disease activity, functional index, and global assessment with questionnaires, and image changes with roentgenography. We also measured human leucocyte antigen-B27 and systemic inflammatory reactants...
March 17, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28300526/effects-of-bone-morphogenetic-protein-4-bmp4-on-in-vitro-development-and-survival-of-bovine-preantral-follicles-enclosed-in-fragments-ovarian-tissue
#2
Ellen de Vasconcelos da Cunha, Glaucinete Borges de Souza, José Renato de Sousa Passos, Anderson Weiny Barbalho Silva, Andressa Minussi Dau, Márcia Viviane Alves Saraiva, Raimundo Nonato Braga Lobo, José Roberto Viana Silva
The aim of this study was to evaluate the effects of different concentrations of BMP4 on activation, development and mRNA expression of GDF9, BMP15, PCNA, Bax and Bcl2 in cultured bovine follicles enclosed in ovarian tissues. Ovarian tissue fragments were cultured for 6 days in α-MEM+ alone or supplemented with different concentrations of BMP4 (10, 50 or 100 ng/ml). Classical histology was performed to analyze follicle growth and morphology, while real-time PCR was used to analyze mRNA levels in fresh and cultured tissues...
March 16, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28287819/the-effect-of-a-breastfeeding-motivation-program-maintained-during-pregnancy-on-supporting-breastfeeding-randomized-controlled-trial
#3
Eda Cangöl, Nevin Hotun Şahin
BACKGROUND: Exclusive breastfeeding is the recommended breastfeeding method for infants during the first 6 postnatal months. OBJECTIVE: This study aimed to increase breastfeeding duration and frequency using a breastfeeding motivation program (BMP), which was structurally based on Pender's Health Promotion Model (HPM) and administered during pregnancy and the postnatal period. The study was also designed to determine the BMP effectiveness in supporting exclusive breastfeeding...
March 13, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28275783/-effects-of-strontium-ranelate-on-the-expression-of-bmp-2-in-the-mid-palatal-suture-of-rats-during-rapid-maxillary-expansion
#4
Chao Xu, Xu-Xia Wang, Ying-Zi Wang, Pan-Pan Yang, Shu-Ya Zhao, Jun Zhang
PURPOSE: To investigate the effects of strontium ranelate on the expression of BMP-2 during rapid maxillary expansion. METHODS: Thirty-six male 6-week- old male Wistar rats were selected. They were randomly divided into 3 groups. Group A was designed as a control group. An expanded application producing 100 g force was fixed between the first and the second molar on both sides of the rats in group B and group C. 600 mg/kg strontium ranelate was given to the rats in group C daily via an orogastric route, while the equal normal saline was given to the rats in group B...
December 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28274194/the-combined-effects-of-nanotopography-and-sr-ion-for-enhanced-osteogenic-activity-of-bone-marrow-mesenchymal-stem-cells-bmscs
#5
Dandan Hu, Kai Li, Youtao Xie, Houhua Pan, Jun Zhao, Liping Huang, Xuebin Zheng
Both surface topography and chemistry have a significant influence on the biological performance of orthopedic implant coatings. In our study, a surface modification strategy embodying bioactive trace element incorporation and nanotopography construction was employed to enhance the osteogenic activity of calcium silicate (Ca-Si) coatings. We developed strontium-loaded nanolayer on plasma sprayed Ca-Si (CS) coating via hydrothermal treatment which was denoted as Sr-NT-CS. The original CS coating and the CS coating modified with similar nanotopography (NT-CS) were studied in parallel...
March 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28262033/fatty-acid-composition-and-anticancer-activity-in-colon-carcinoma-cell-lines-of-prunus-dulcis-seed-oil
#6
Filiz Mericli, Eda Becer, Hilal Kabadayı, Azmi Hanoglu, Duygu Yigit Hanoglu, Dudu Ozkum Yavuz, Temel Ozek, Seda Vatansever
CONTEXT: Almond oil is used in traditional and complementary therapies for its numerous health benefits due to high unsaturated fatty acids content. OBJECTIVES: This study investigated the composition and in vitro anticancer activity of almond oil from Northern Cyprus and compared with almond oil from Turkey. MATERIALS AND METHODS: Almond oil from Northern Cyprus was obtained by supercritical CO2 extraction and analyzed by GC-MS. Almond oil of Turkey was provided from Turkish pharmacies...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28260060/bioinformatics-analysis-on-the-differentiation-of-bone-mesenchymal-stem-cells-into-osteoblasts-and-adipocytes
#7
Xiaoyuan Xu, He Jiang, Xingnuan Li, Ping Wu, Jianyun Liu, Tao Wang, Xiaoou Zhou, Jianjun Xiong, Weidong Li
The present study aimed to screen several differentially expressed genes (DEGs) and differentially expressed microRNAs (miRNAs) for two types of mesenchymal stem cell (MSC) differentiation. Bone morphogenetic protein 6 (BMP‑6) and dexamethasone were used to induce MSCs towards osteoblastic differentiation or adipocytic differentiation. The t‑test in the Bioconductor bioinformatics software tool was used to screen DEGs and differentially expressed miRNAs in the two samples. Subsequent gene ontology (GO) and pathway analyses on the DEGs were performed using the GO and Kyoto Encyclopedia of Genes and Genomes databases, respectively; potential target genes for the screened miRNAs were predicted using the TargetScan database...
February 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28256809/insulin-like-growth-factor-1-igf-1-enhances-the-osteogenic-activity-of-bone-morphogenetic-protein-6-bmp-6-in-vitro-and-in-vivo-and-together-have-a-stronger-osteogenic-effect-than-when-igf-1-is-combined-with-bmp-2
#8
Gustavo A Rico-Llanos, Jose Becerra, Rick Visser
Bone morphogenetic protein-2 (BMP-2) is widely used in orthopedic surgery and bone tissue engineering because of its strong osteogenic activity. However, BMP-2 treatments have several drawbacks and many groups are actively exploring alternatives. Since BMP-6 has been demonstrated to be more osteoinductive, its use, either alone or together with other growth factors, might be an interesting option. In this work we have compared the osteogenic effect of BMP-2, BMP-6 or insulin-like growth factor-1 (IGF-1), either alone or in combination...
March 3, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28256803/chitosan-agarose-scaffolds-supports-chondrogenesis-of-human-wharton-s-jelly-mesenchymal-stem-cells
#9
L P Merlin Rajesh Lal, G K Suraishkumar, Prabha D Nair
Tissue engineering strategies for cartilage aim to restore the complex biomechanical and biochemical properties of the native cartilage. To mimic the in-vivo microenvironment, we developed a novel scaffold based on chitosan-agarose (CHAG scaffold) resembling the properties of native cartilage extracellular matrix that aids in-vitro cartilage formation. The CHAG scaffolds had pore size ranging from 75 µm to 300 µm and the degradation of 18% over 6 months in PBS. L929 cells and Human Wharton's Jelly Mesenchymal Stem Cells (HWJ-MSCs) attached well and grew in the CHAG scaffolds...
March 3, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28254298/2-n-6-o-sulfated-chitosan-assisted-bmp-2-immobilization-of-pcl-scaffolds-for-enhanced-osteoinduction
#10
Lingyan Cao, Yuanman Yu, Jing Wang, Jerome A Werkmeister, Keith M McLean, Changsheng Liu
The aim of this study was to develop a 2-N, 6-O-sulfated chitosan (26SCS) modified electrospun fibrous PCL scaffold for bone morphogenetic protein-2 (BMP-2) delivery to improve osteoinduction. The PCL scaffold was modified by an aminolysis reaction using ethylenediamine (ED) and 26SCS was immobilized via electrostatic interactions (PCL-N-S). Scaffolds were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and contact angle measurements...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28251965/-amphioxus-ortholog-of-ecsit-an-evolutionarily-conserved-adaptor-in-the-toll-and-bmp-signaling-pathways
#11
Y H Lin, W Zhang, J W Li, H W Zhang, D Y Chen
In vertebrates, evolutionarily conserved signaling intermediate in the Toll pathway (ECSIT) interacts with the TNF-receptor associated factor 6 (TRAF6) to regulate the processing of MEKK1, activate NF-κB, and also control BMP target genes. However, the role of ECSIT in invertebrates remains largely unexplored. We performed comparative investigations of the expression, gene structure, and phylogeny of ECSIT, Toll-like receptor (TLR), and Smad4 in the cephalochordate Branchiostoma belcheri. Phylogenetic analysis indicated that, in amphioxus, ECSIT, TLR, and Smad4 form independent clusters at the base of Chordate   clusters...
January 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28247086/tsg-6-secreted-by-mesenchymal-stem-cells-suppresses-immune-reactions-influenced-by-bmp-2-through-p38-and-mek-mitogen-activated-protein-kinase-pathway
#12
Soyoun Um, Hui Young Kim, Joo-Hee Lee, In-Seok Song, Byoung Moo Seo
Bone morphogenetic protein 2 (BMP-2) has a critical function in bone and cartilage development and in repairing damaged organs and tissue. However, clinical use of BMP-2 at doses of 0.5-1 mg/ml for orthopedics has been associated with severe postoperative swelling requiring emergency surgical intervention. We determined whether a high concentration of BMP-2 induces inflammatory responses in macrophages and the suppression of osteogenesis in hMSCs. We obtained human periodontal ligament stem cells and bone marrow stem cells from the maxilla, i...
February 28, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28244247/regulatory-effects-of-bone-morphogenetic-protein-4-on-tumour-necrosis-factor-%C3%AE-suppressed-runx2-and-osteoprotegerin-expression-in-cementoblasts
#13
Yunlong Wang, Hong He, Zhengguo Cao, Yi Fang, Mingyuan Du, Zhijian Liu
OBJECTIVES: Root resorption is a common phenomenon presented in periodontitis and orthodontic treatment, both of which are accompanied by an elevated TNF-α expression level in the periodontal tissues. Previously, we proved that TNF-α showed an inhibitory effect on cementoblast differentiation, mineralization and proliferation. However, the effect of TNF-α on Runx2 and osteoprotegerin (OPG) expression remains undetermined. This study aimed to identify the influence of TNF-α on Runx2 and OPG expression in cementoblasts and to test whether BMP-2,-4,-6,-7 would affect TNF-α-regulated Runx2 and OPG...
February 28, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28240868/zns-nanoparticles-sensitize-luminescence-of-capping-ligand-bound-lanthanide-ions
#14
Rodney A Tigaa, Gary J Lucas, Ana de Bettencourt-Dias
2,6-Bis(diethylamide)-4-oxo(3-thiopropane)pyridine (BDP) and 2,6-bis(methyl ester)-4-oxo(3-thiopropane)pyridine (BMP) were synthesized. These compounds chelated Ln(III) ions and sensitized their emission. The 3:1 complexes of BDP displayed efficiencies of 18% and 12% for Eu(III) and Tb(III), respectively. The analogous complexes of BMP had efficiencies of 23% and 18% for Eu(III) and Tb(III), respectively. Both BDP and BMP were used to cap ZnS nanoparticles (NPs) in a one-pot synthesis, and then Ln(III) ions were added, resulting in systems with metal ions at the surface of the capped NPs...
February 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28229387/the-effects-of-cerium-valence-states-at-cerium-oxide-coatings-on-the-responses-of-bone-mesenchymal-stem-cells-and-macrophages
#15
Mingyu You, Kai Li, Youtao Xie, Liping Huang, Xuebin Zheng
Ideal orthopedic coatings should trigger good osteogenic response and limited inflammatory response. The cerium valence states in ceria are associated with their anti-oxidative activity and anti-inflammatory property. In the study, we prepared two kinds of plasma sprayed CeO2 coatings with different Ce(4+) concentrations to investigate the effects of Ce valence states on the response of bone mesenchymal stem cells (BMSCs) and macrophage RAW264.7. Both the coatings (CeO2-A and CeO2-B) were characterized via XRD, SEM, and X-ray photoelectron spectroscopy...
February 22, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28226262/an-urban-runoff-model-designed-to-inform-stormwater-management-decisions
#16
Nicole G Beck, Gary Conley, Lisa Kanner, Margaret Mathias
We present an urban runoff model designed for stormwater managers to quantify runoff reduction benefits of mitigation actions that has lower input data and user expertise requirements than most commonly used models. The stormwater tool to estimate load reductions (TELR) employs a semi-distributed approach, where landscape characteristics and process representation are spatially-lumped within urban catchments on the order of 100 acres (40 ha). Hydrologic computations use a set of metrics that describe a 30-year rainfall distribution, combined with well-tested algorithms for rainfall-runoff transformation and routing to generate average annual runoff estimates for each catchment...
May 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28218774/osteoblast-differentiation-of-rabbit-adipose-derived-stem-cells-by-polyethylenimine-mediated-bmp-2-gene-transfection-in-vitro
#17
Q F Wang, Y Huang, G C He, H S Wang, Z H Chen, X H Cai, Y H Xie, Q Liu
The aim of this study was to examine the efficiency of polyethylenimine-mediated transfection of the human bone morphogenetic protein-2 (BMP-2) gene into rabbit adipose-derived stem cells (ADSCs), and its effect on osteoblast differentiation. Adipose tissue was isolated from the necks of adult Japanese white rabbits and cultured in vitro to obtain ADSCs. Gene delivery of BMP-2 was mediated by polyethylenimine and stable transformants were selected by G-418. The expression of BMP-2 mRNA was confirmed by reverse transcription-polymerase chain reaction, and of the BMP-2 protein by ELISA...
February 16, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28214472/bmp-12-activates-tenogenic-pathway-in-human-adipose-stem-cells-and-affects-their-immunomodulatory-and-secretory-properties
#18
Weronika Zarychta-Wiśniewska, Anna Burdzinska, Agnieszka Kulesza, Kamila Gala, Beata Kaleta, Katarzyna Zielniok, Katarzyna Siennicka, Marek Sabat, Leszek Paczek
BACKGROUND: Cell-based therapy is a treatment method in tendon injuries. Bone morphogenic protein 12 (BMP-12) possesses tenogenic activity and was proposed as a differentiating factor for stem cells directed to transplantation. However, BMPs belong to pleiotropic TGF-β superfamily and have diverse effect on cells. Therefore, the aim of this study was to determine if BMP-12 induces tenogenic differentiation of human adipose stem cells (hASCs) and how it affects other features of this population...
February 18, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/28202997/-a-novel-tissue-engineered-bone-constructed-by-using-human-adipose-derived-stem-cells-and-biomimetic-calcium-phosphate-scaffold-coprecipitated-with-bone-morphogenetic-protein-2
#19
W R Jiang, X Zhang, Y S Liu, G Wu, Y J Ge, Y S Zhou
OBJECTIVE: To construct a novel biomimetic calcium phosphate (BioCaP) scaffold loaded with bone morphogenetic protein-2 (BMP-2), and to investigate its role in the osteogenesis of human adipose-derived stem cells (hASCs) in vitro and in vivo. METHODS: The BioCaP scaffold coprecipitated with BMP-2 (BMP-2-BioCaP) was constructed in this study. Field emission scanning electron microscopy (SEM) was used to analyze the morphology of the surfaces. The release kinetics was measured to evaluate the slow-release characteristics in vitro...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28197731/comparison-of-the-effects-of-recombinant-human-bone-morphogenetic-protein-2-and-9-on-bone-formation-in-rat-calvarial-critical-size-defects
#20
Toshiaki Nakamura, Yoshinori Shirakata, Yukiya Shinohara, Richard J Miron, Kozue Hasegawa-Nakamura, Masako Fujioka-Kobayashi, Kazuyuki Noguchi
OBJECTIVES: Among bone morphogenetic protein (BMP) family members, BMP-2 and BMP-9 have demonstrated potent osteoinductive potential. However, in vivo differences in their potential for bone regeneration remain unclear. The present study aimed to compare the effects of recombinant human (rh) BMP-2 and rhBMP-9 on bone formation in rat calvarial critical-size defects (CSD). MATERIALS AND METHODS: Twenty-eight Wistar rats surgically received two calvarial defects bilaterally in each parietal bone...
February 14, 2017: Clinical Oral Investigations
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