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Juan Bai, Ying Zhu, Ying Dong
ETHNOPHARMACOLOGICAL RELEVANCE: Bitter melon (Momordica charantia L.) is rich in a variety of biologically active ingredients, and has been widely used in traditional Chinese medicine (TCM) to treat various diseases, including type 2 diabetes and obesity. AIM OF THE STUDY: We aimed to investigate how bitter melon powder (BMP) could affect obesity-associated inflammatory responses to ameliorate high-fat diet (HFD)-induced insulin resistance, and investigated whether its anti-inflammatory properties were effected by modulating the gut microbiota...
October 14, 2016: Journal of Ethnopharmacology
Marco Antonio Alarcón, Karla Tatiana Diaz, Luisiana Aranda, Emilio Alfredo Cafferata, Clovis Mariano Faggion, Alberto Monje
PURPOSE: The use of biologic agents is emerging in bone regeneration procedures due to their ability to increase cellular events in wound healing and therefore to obtain more predictable outcomes. Hence, the aim of the present study was to critically evaluate the methodology of systematic reviews investigating biologic agents in promoting bone formation and implant site development. MATERIALS AND METHODS: A literature search for systematic reviews with and without meta-analyses was performed in Medline, Embase, and the Cochrane database, as well as in journals with high impact factors in periodontics and implant dentistry...
October 14, 2016: International Journal of Oral & Maxillofacial Implants
Wei Wei, Biao-Fang Wei, Jian Cai, Wei He, Lin Wan, Ying Guan
OBJECTIVE: The aim of the study was to explore the efficacy of Fu-Yuan Capsule in the healing of fractures of the lower end of the radius in a rabbit model. METHODS: After establishing a rabbit fracture model, all animals were randomly divided into the model group (n = 24), the Fu-Yuan Capsule group (n = 24), and the Shenyang Hongyao group (n = 24). The X-ray was applied to observe the course of fracture healing at 2, 4, 6, and 8 weeks after treatment. Haematoxylin-eosin staining and immunohistochemical staining were used to determine the histological change and the expression of bone morphogenetic protein-2 (BMP-2)...
October 14, 2016: Pharmacology
Daniel S Thoma, Jae-Kook Cha, Vitor M Sapata, Ronald E Jung, Juerg Hüsler, Ui-Won Jung
OBJECTIVES: To test whether or not one of two biological mediators (recombinant human bone morphogenetic protein-2 (rhBMP-2) and recombinant human platelet-derived growth factor (rhPDGF-BB)) is superior to the other and compared with control groups for bone regeneration around implants based on histomorphometrical outcome measures. MATERIALS AND METHODS: Box-type defects (10 × 5 × 5 mm) were prepared on the buccal sides of the left and right edentulous ridge in ten mongrel dogs...
October 10, 2016: Clinical Oral Implants Research
Kae Sian Tay, Anupreet Bassi, William Yeo, Wai Mun Yue
BACKGROUND CONTEXT: There is no current literature comparing outcomes of patients with and without lumbar scoliosis having neurological symptoms undergoing Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS TLIF) technique. PURPOSE: To determine whether associated lumbar scoliosis will result in different clinical, radiological and operative outcomes in patients undergoing focal MISTLIF for neurogenic symptoms, without specific correction of the scoliosis...
October 7, 2016: Spine Journal: Official Journal of the North American Spine Society
Felix Sellberg, Erik Berglund, Martin Ronaghi, Gabriel Strandberg, Helena Löf, Pehr Sommar, Norbert Lubenow, Folke Knutson, David Berglund
BACKGROUND: Platelet lysate is a readily available source of growth factors, and other mediators, which has been used in a variety of clinical applications. However, the product remains poorly standardized and the present investigation evaluates the composition of platelet lysate obtained from either fresh or stored pathogen-inactivated platelet units. MATERIALS AND METHODS: Platelet pooled units (n = 10) were obtained from healthy blood donors and tested according to standard procedures...
September 28, 2016: Transfusion and Apheresis Science
Freddy Witarsa, Stephanie Lansing, Stephanie Yarwood, Martina Gonzalez Mateu
The methanogenic communities in alternative inocula and their potential to increase CH4 production in mesophilic and psychrophilic dairy manure-based anaerobic digesters were examined. Quantitative-PCR and terminal restriction fragment length polymorphism (T-RFLP) profiles were used to determine archaeal and methanogenic community changes when three inocula (wetland sediment (WS), landfill leachate (LL), and mesophilic digestate (MD)) were incubated at 15, 25, and 35 °C for 91 and 196 days. After each incubation period, the inocula were used in biochemical methane potential (BMP) tests at the incubation temperatures...
October 7, 2016: Applied Microbiology and Biotechnology
Patrick Haubruck, Andreas Kammerer, Sebastian Korff, Philipp Apitz, Kai Xiao, Axel Büchler, Bahram Biglari, Gerald Zimmermann, Volker Daniel, Gerhard Schmidmaier, Arash Moghaddam
The local application of bone morphogenetic protein-7 (BMP-7) in combination with the transplantation of autologous bone graft improves the outcome in nonunion treatment; however, the specific reasons remain unclear. In this study, we sought to determine if the local application of BMP-7 contributes to improved bone regeneration in nonunion therapy by modulation of the angiogenic and inflammable cytokine expression patterns of the early inflammation response. Therefore, we utilized the analysis of serological cytokine expression patterns...
2016: Journal of Inflammation Research
Anahita Mehdizadeh, Mohammad Hasan Sheikhha, Seyed Mehdi Kalantar, Bibi Shahnaz Aali, Azam Ghanei
BACKGROUND: With the prevalence of 6-10%, polycystic ovarian syndrome (PCOS) is considered the most common endocrinological disorder affecting women in their reproductive age. It has been suggested that genetic factors participate in the development of PCOS. Follicular development has been considered as one of the impaired processes in PCOS. Bone morphogenetic protein-15 (BMP-15) gene is a candidate gene in follicular development and its variants may play role in pathogenesis of PCOS...
August 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
Yukiko Maeda, Nicholas H Farina, Melissa M Matzelle, Paul J Fanning, Jane B Lian, Ellen M Gravallese
Articular bone erosion in rheumatoid arthritis (RA) is mediated by the interaction between inflammation and pathways regulating bone metabolism. Inflammation promotes osteoclastogenesis and also inhibits osteoblast function, further contributing to the persistence of erosions. MicroRNAs (miRNAs) are important regulators of skeletal remodeling and play a role in RA pathogenesis. We therefore determined the expression of miRNAs in inflamed synovial tissue and the role they play in pathways regulating osteoblast and osteoclast function...
September 27, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Ching-Jen Wang, Chung-Cheng Huang, Hon-Kan Yip, Ya-Ju Yang
BACKGROUND: This study investigated the effects of different dosages of extracorporeal shockwave therapy (ESWT) in early osteonecrosis of the femoral head (ONFH). MATERIALS AND METHODS: Thirty-three patients (42 hips) were randomly divided into three groups. Group A (10 patients with 16 hips) received 2000 impulses of ESWT at 24 Kv to the affected hip. Group B (11 patients with 14 hips) and Group C (12 patients with 12 hips) received 4000 and 6000 impulses of ESWT respectively...
September 21, 2016: International Journal of Surgery
Wen-Xiu Hao, Yun-Tao Zhang, Ya-Jie Zhang
PURPOSE: To explore the effect of cinnamaldehyde(CA) on osteogenic function and BMP-2 expression of mice osteoblast. METHODS: MC3T3-E1 sub-clone 14 cells were cultured in the presence of CA at 0(control group), 10, 20, 40, 80, 160, 320 μg/mL. The cell proliferation rate was measured by MTT assay 1, 3, 5 d after exposure. Activity of alkaline phosphatase (ALP) was detected at 3, 5, 7 d to observe the effect of 6 concentrations of CA on osteoblast function. The mRNA expression of BMP-2 was quantified by real-time PCR(RT-qPCR) 1, 3, 5 d after exposure to (10,20 μg/mL) CA...
June 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
J Banach, W Gilewski, A Słomka, K Buszko, J Błażejewski, D Karasek, D Rogowicz, E Żekanowska, W Sinkiewicz
Derangement of bone morphogenetic protein (BMP) signalling was observed in cardiovascular disorders. The present study assesses the diagnostic and prognostic value of BMP6 plasma concentration in chronic heart failure (CHF). 130 CHF patients and 32 controls participated in the study. BMP6 plasma level was measured at baseline. During 12-month follow-up death and hospitalisation with CHF exacerbation were recorded. BMP6 was significantly increased in CHF patients with highest concentration in most advanced CHF...
September 4, 2016: Clinical and Experimental Pharmacology & Physiology
Hyeyoon Chang, Seo-Eun Oh, Seunghan Oh, Kyung-Seok Hu, Sungtae Kim
PURPOSE: The aim of this study was to characterize the healing in the grafted calvarial defects of rats after adjunctive hyperbaric oxygen therapy. METHODS: Twenty-eight male Sprague-Dawley rats (body weight, 250-300 g) were randomly divided into two treatment groups: with hyperbaric oxygen therapy (HBO; n=14) and without HBO (NHBO; n=14). Each group was further subdivided according to the bone substitute applied: biphasic calcium phosphate (BCP; n=7) and surface-modified BCP (mBCP; n=7)...
August 2016: Journal of Periodontal & Implant Science
Ayodele A Alaiya, Mahmoud Aljurf, Zakia Shinwari, Fahad Almohareb, Hafiz Malhan, Hazzaa Alzahrani, Tarek Owaidah, Jonathan Fox, Fahad Alsharif, Said Y Mohamed, Walid Rasheed, Ghuzayel Aldawsari, Amr Hanbali, Syed Osman Ahmed, Naeem Chaudhri
There is unmet need for prediction of treatment response for chronic myeloid leukemia (CML) patients. The present study aims to identify disease-specific/disease-associated protein biomarkers detectable in bone marrow and peripheral blood for objective prediction of individual's best treatment options and prognostic monitoring of CML patients. Bone marrow plasma (BMP) and peripheral blood plasma (PBP) samples from newly-diagnosed chronic-phase CML patients were subjected to expression-proteomics using quantitative two-dimensional gel electrophoresis (2-DE) and label-free liquid chromatography tandem mass spectrometry (LC-MS/MS)...
September 2016: International Journal of Oncology
Ruchi Mishra, Ryan S Sefcik, Tyler J Bishop, Stefani M Montelone, Nisha Crouser, Jean F Welter, Arnold I Caplan, David Dean
One approach to the development of an artificial graft material could rely on uniform coverage of a resorbable biomaterial with bone extracellular matrix (ECM). To achieve this on the surface of poly(propylene fumarate) (PPF) scaffolds, we selected a growth factor regime of basic fibroblast growth factor (FGF-2) (5 ng/mL), platelet-derived growth factor (PDGF-BB) (40 ng/mL), and epidermal growth factor (EGF) (20 ng/mL) to stimulate proliferation of bone marrow-derived human mesenchymal stem cells (BM-hMSCs)...
September 2016: Tissue Engineering. Part C, Methods
Liu Hong, Thad Sharp, Behnoush Khorsand, Carol Fischer, Steven Eliason, Ali Salem, Adil Akkouch, Kim Brogden, Brad A Amendt
MicroRNAs (miRs) regulate inflammation and BMP antagonists, thus they have potential uses as therapeutic reagents. However, the molecular function of miR-200c in modulating proinflammatory and bone metabolic mediators and osteogenic differentiation is not known. After miR-200c was transduced into a human embryonic palatal mesenchyme (HEPM) (a cell line of preosteoblasts), using lentiviral vectors, the resulting miR-200c overexpression increased osteogenic differentiation biomarkers, including osteocalcin (OCN) transcripts and calcium content...
2016: PloS One
Shunli Wang, Gary L Hawkins, Brian H Kiepper, Keshav C Das
Accumulation of ammonia, measured as total ammonia nitrogen (TAN), a product of protein decomposition in slaughterhouse wastes, inhibits the anaerobic digestion process, reducing digester productivity and leading to failure. Struvite precipitation (SP) is an effective means to remove TAN and enhance the buffering of substrates. Different Mg and P sources were evaluated as reactants in SP in acidogenic digester effluents to reduce its TAN levels. In order to measure impact of TAN removal, a standard biochemical methane potential (BMP) test was conducted to measure methane yield from treatments that had the highest TAN reductions...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
J Z Tan, E M Nie, C Y Zhang, R Jiang
OBJECTIVE: To investigate the effect of zinc ion on the expression of osteoblastic proteins. METHODS: Mice osteoblasts MC3T3-E1 cells were subcultured. Inflammatory environment model was established by tumor necrosis factor α(TNF-α)at a concentration of 10 mg/L. According to different concentration of Zn(2+), the cells were divided into TNF-α group, control group, group A(TNF-α+10(-4) mol/L Zn(2+)), group B(TNF-α+10(-5) mol/L Zn(2+)), group C(TNF-α+10(-6) mol/L Zn(2+))...
August 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
A Moghaddam, C Ermisch, C Fischer, S Zietzschmann, G Schmidmaier
BACKGROUND: The treatment of non-unions with large bone defects or osteitis is a major challenge in orthopedic and trauma surgery. A new concept of therapy is a two-step procedure: Masquelet technique according to the diamond concept. METHODS: Between February 2010 and June 2014, 55 patients with tibia non-unions or infections were treated in a two-step Masquelet technique in our center. The patients' average age was 48 (median 50; minimum 15-maximum 72) with an average BMI (body mass index) of 28 (27; 18-52)...
August 4, 2016: Der Orthopäde
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