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https://www.readbyqxmd.com/read/28430722/the-use-of-liposomal-bupivacaine-administered-with-standard-bupivacaine-in-ankle-fractures-requiring-open-reduction-internal-fixation-a-single-blinded-randomized-controlled-trial
#1
Roy Davidovitch, Abraham Goch, Adam Driesman, Sanjit Konda, Christian Pean, Kenneth Egol
OBJECTIVES: To determine the efficacy of liposomal bupivacaine compared to placebo for post-operative pain control in patients undergoing operative fixation of ankle fractures. DESIGN: Prospective single blinded randomized control trial SETTING:: Academic Medical CenterPatients/Participants: After IRB approval, seventy-six patients who sustained an acute ankle fracture (OTA 44A-C) requiring operative fixation met inclusion criteria. INTERVENTION: Patients were randomly assigned to one of two groups, control (local intra-operative sterile saline injection under general anesthesia) or interventional (local intra-operative liposomal bupivacaine and bupivacaine injection under general anesthesia)...
April 6, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28236348/fixed-time-interval-compared-with-on-demand-oral-analgesia-protocols-for-post-caesarean-pain-a-randomised-controlled-trial
#2
E Yefet, H Taha, R Salim, J Hasanein, Y Carmeli, N Schwartz, Z Nachum
OBJECTIVES: To compare the efficacy, safety and satisfaction from two modes of oral analgesia administration for the treatment of post-caesarean pain in the first 48 h following surgery: on-demand versus fixed time interval administration. DESIGN: Open label parallel-group, randomised-controlled trial from February to December 2013. SETTING: University-affiliated hospital in Israel. POPULATION: Two-hundred women who underwent caesarean delivery with regional anaesthesia...
June 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28097095/limited-knowledge-of-acetaminophen-in-patients-with-liver-disease
#3
Sammy Saab, Peter G Konyn, Matthew R Viramontes, Melissa A Jimenez, Jonathan F Grotts, Wally Hamidzadah, Veronica P Dang, Negin L Esmailzadeh, Gina Choi, Francisco A Durazo, Mohamed M El-Kabany, Steven-Huy B Han, Myron J Tong
Background and Aims: Unintentional acetaminophen overdose remains the leading cause of acute liver failure in the United States. Patients with underlying liver disease are at higher risk of poor outcomes from acetaminophen overdose. Limited knowledge of acetaminophen may be a preventable contributor to elevated rates of overdose and thus acute liver failure. The purpose of this study is to assess knowledge of acetaminophen dosing and presence of acetaminophen in common combination products in patients with liver disease...
December 28, 2016: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/27753591/a-case-of-pulmonary-foreign-body-granulomatosis-secondary-to-intravenous-injection-of-acetaminophen-oxycodone
#4
Pratik Naik, Laura Cashin, Sonny Huitron
Foreign body granulomatosis is a rare complication of intravenous injection of pulverized oral prescription tablets. We present the case of an active duty male who was ultimately diagnosed with foreign body granulomatosis caused by the crushing and intravenous injection of acetaminophen with oxycodone (Percocet). The 24-year-old patient initially presented with multiple syncopal episodes, hemoptysis and hypoxia. The patient presentation and imaging findings involved in foreign body granulomatosis can mimic many pulmonary disorders and can be widely variable...
October 2016: Military Medicine
https://www.readbyqxmd.com/read/27568339/exploring-trends-of-nonmedical-use-of-prescription-drugs-and-polydrug-abuse-in-the-twittersphere-using-unsupervised-machine-learning
#5
Janani Kalyanam, Takeo Katsuki, Gert R G Lanckriet, Tim K Mackey
INTRODUCTION: Nonmedical use of prescription medications/drugs (NMUPD) is a serious public health threat, particularly in relation to the prescription opioid analgesics abuse epidemic. While attention to this problem has been growing, there remains an urgent need to develop novel strategies in the field of "digital epidemiology" to better identify, analyze and understand trends in NMUPD behavior. METHODS: We conducted surveillance of the popular microblogging site Twitter by collecting 11 million tweets filtered for three commonly abused prescription opioid analgesic drugs Percocet® (acetaminophen/oxycodone), OxyContin® (oxycodone), and Oxycodone...
February 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/27493471/laparoscopic-total-extraperitoneal-hernia-repair-outcomes
#6
Mark A Reiner, Erin R Bresnahan
BACKGROUND AND OBJECTIVES: Laparoscopic inguinal hernia repair has become increasingly popular as an alternative to open surgery. The purpose of this study was to evaluate the safety and effectiveness of the laparoscopic total extraperitoneal procedure with the use of staple fixation and polypropylene mesh. METHODS: A retrospective chart review examined outcomes of 1240 laparoscopic hernia operations in 783 patients, focusing on intraoperative and early postoperative complications, pain, and time until return to work and normal physical activities...
July 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/27467181/the-prevalences-of-and-association-between-nonmedical-prescription-opioid-use-and-poor-sleep-among-chinese-high-school-students
#7
Daiting Tang, Pengsheng Li, Lan Guo, Yan Xu, Xue Gao, Jianxiong Deng, Jinghui Huang, Guoliang Huang, Hong Wu, Yue Yue, Ciyong Lu
The purpose of this study was to investigate the prevalences of and association between nonmedical prescription opioid use (NMPOU) and sleep quality among Chinese high school students. A cross-sectional study was conducted in Chongqing high school students in 2012, and questionnaires from 18,686 students were completed and eligible for this study. Demographic and NMPOU information was collected using a self-administered questionnaire. The Chinese Pittsburgh Sleep Quality index (CPSQI) was used to assess the occurrence of poor sleep...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26582851/pregabalin-reduces-postoperative-opioid-consumption-and-pain-for-1-week-after-hospital-discharge-but-does-not-affect-function-at-6-weeks-or-3-months-after-total-hip-arthroplasty
#8
RANDOMIZED CONTROLLED TRIAL
H Clarke, G M Pagé, C J L McCartney, A Huang, P Stratford, J Andrion, D Kennedy, I T Awad, J Gollish, J Kay, J Katz
BACKGROUND: This study examined whether a perioperative regimen of pregabalin added to celecoxib improved pain scores and functional outcomes postdischarge up to 3 months after total hip arthroplasty (primary outcome) and acute postoperative pain and adverse effects (secondary outcomes). METHODS: One hundred and eighty-four patients were enrolled in a randomized, double-blind, placebo-controlled study. Two hours before receiving a spinal anaesthetic and undergoing surgery, patients received celecoxib 400 mg p...
December 2015: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/26527898/profile-of-extended-release-oxycodone-acetaminophen-for-acute-pain
#9
REVIEW
Mary Hanna Bekhit
This article provides a historical and pharmacological overview of a new opioid analgesic that boasts an extended-release (ER) formulation designed to provide both immediate and prolonged analgesia for up to 12 hours in patients who are experiencing acute pain. This novel medication, ER oxycodone/acetaminophen, competes with current US Food and Drug Administration (FDA)-approved opioid formulations available on the market in that it offers two benefits concurrently: a prolonged duration of action, and multimodal analgesia through a combination of an opioid (oxycodone) with a nonopioid component...
2015: Journal of Pain Research
https://www.readbyqxmd.com/read/26364675/drug-use-in-the-twittersphere-a-qualitative-contextual-analysis-of-tweets-about-prescription-drugs
#10
Lukas Shutler, Lewis S Nelson, Ian Portelli, Courtney Blachford, Jeanmarie Perrone
Tweets about prescription opioid use may reveal insights into the prescription drug epidemic. We qualitatively assessed 2,100 tweets about prescription opioids utilizing a Twitter Archiving Google Spreadsheet® and determined whether the tweet represented: abuse (i.e., use to get high), not abuse (i.e., use as analgesic), or was not characterizable (e.g., "I need a Percocet") and whether the connotation was positive (i.e. promote psychoactive or analgesic use), negative (i.e., adverse event), or not characterizable...
2015: Journal of Addictive Diseases
https://www.readbyqxmd.com/read/26192735/subcutaneous-injection-of-percocet-a-case-of-severe-soft-tissue-loss
#11
Sean M Baskin, Christine Abboud, Wendy Chen, Eric Tolchin, Robert W Kelly, Ariel M Aballay
Prescription drug abuse ranks as the second most common class of illicit drug use in the United States, and one mechanism of opiate abuse involves intravenous injection of enteral narcotics such as oxycodone or hydrocodone. The authors describe a patient who sustained significant soft tissue necrosis after intravenously injecting a solution made from crushed enteral narcotics, with a focus on the operative course that resulted due to a delay in initial definitive treatment. The patient's wounds encompassed 8% total body surface area and covered 247 cm2...
July 2015: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/25822637/use-of-opioid-pain-relievers-following-extraction-of-third-molars
#12
Breanna M Weiland, Anthony G Wach, Brent P Kanar, Matthew T Castele, Mark F Sosovicka, Matthew R Cooke, Paul A Moore
Following extraction of third molars, it is common practice for oral and maxillofacial surgeons to provide a prescription for an opioid-containing analgesic such as hydrocodone with acetaminophen. Because the instructions for use most often indicate that these analgesics are to be taken "as needed for pain," it is unknown how many of the prescribed postoperative analgesic tablets are needed and actually taken. Therefore, an assessment of patient pain experiences and actual opioid analgesic usage was carried out using structured telephone interviews of patients performed 1 and 7 days following their thirdmolar extraction surgery...
February 2015: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/25709842/long-term-anticoagulation-4-16-years-stops-progression-of-idiopathic-hip-osteonecrosis-associated-with-familial-thrombophilia
#13
Charles J Glueck, Richard A Freiberg, Robert Wissman, Ping Wang
In 6 patients with familial thrombophilia (5 Factor V (FV) Leiden heterozygotes, 1 with resistance to activated protein C (RAPC)), we prospectively assessed whether continuous longterm (4-16 years) anticoagulation would prevent progression of idiopathic osteonecrosis (ON), ameliorate pain, and facilitate functional recovery. Four men and 2 women (9 hips, 8 Ficat stage II, 1 stage I) were anticoagulated with enoxaparin (60 mg/day) for 3 months and subsequently with Coumadin, Xarelto, or Pradaxa, warranted by ≥2 prior thrombotic events...
2015: Advances in Orthopedics
https://www.readbyqxmd.com/read/24238956/-every-never-i-ever-said-came-true-transitions-from-opioid-pills-to-heroin-injecting
#14
COMPARATIVE STUDY
Sarah G Mars, Philippe Bourgois, George Karandinos, Fernando Montero, Daniel Ciccarone
This qualitative study documents the pathways to injecting heroin by users in Philadelphia and San Francisco before and during a pharmaceutical opioid pill epidemic. Data was collected through in-depth, semi-structured interviews (conducted between 2010 and 2012) that were, conducted against a background of longer-term participant-observation, ethnographic studies of street-based drug users and dealers in Philadelphia (2007-12) and San Francisco (1994-2007, 2012). Philadelphia and San Francisco were selected for their contrasting political economies, immigration patterns and source type of heroin...
March 2014: International Journal on Drug Policy
https://www.readbyqxmd.com/read/24060097/the-pill-hustle-risky-pain-management-for-a-gunshot-victim
#15
Jooyoung Lee
How do gunshot victims manage pain without health care? This paper examines this question through ethnographic data of a single gunshot victim who self-medicated with Percocet. The observations for this paper were collected in Philadelphia between January of 2010 and October of 2011, and were part of a larger ethnographic study that included 40 gunshot victims recruited from an outpatient trauma clinic. Although this victim was able to manage his pain, he ultimately became addicted to Percocet and became entangled in the personal stress and conflicts of his pill hustlers...
December 2013: Social Science & Medicine
https://www.readbyqxmd.com/read/23880443/elevated-acetaminophen-concentration-measured-after-nasal-insufflation-of-percocet%C3%A2
#16
Nicole Reid, Maryann Mazer-Amirshahi, Cathleen Clancy, Laura James, John van den Anker
BACKGROUND: Prescription opioid products are often formulated with acetaminophen, but the pharmacokinetics of nasally administered acetaminophen are poorly characterized. We report a case of a potentially toxic acetaminophen concentration after nasal insufflation of oxycodone/acetaminophen tablets. CASE REPORT: A 38-year-old female presented to the emergency department after 2 days of nasally insufflating a total of 50 oxycodone/acetaminophen 5/325 mg tablets...
November 2013: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/23802330/use-of-opioids-to-control-arthritis-pain-under-scrutiny-increase-in-falls-fractures-in-older-adults-attributed-to-narcotic-painkillers-such-as-oxycodone-vicodin-or-percocet
#17
(no author information available yet)
No abstract text is available yet for this article.
May 2013: DukeMedicine Healthnews
https://www.readbyqxmd.com/read/23688842/a-national-study-of-substance-use-behaviors-among-ncaa-male-athletes-who-use-banned-performance-enhancing-substances
#18
RANDOMIZED CONTROLLED TRIAL
Jennifer F Buckman, Samantha G Farris, David A Yusko
BACKGROUND: Reports of illicit substance use by college athletes have become commonplace in recent years, yet comparatively little effort has been put forth by the research community to understand these behaviors. METHODS: Data for this study came from a large, national dataset collected by the National Collegiate Athletic Association (NCAA). This study compared substance use behaviors of male undergraduate student athletes who reported using ergogenic performance enhancing substances (e...
July 1, 2013: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/23076842/my-story-how-one-percocet-prescription-triggered-my-addiction
#19
EDITORIAL
John Doe
No abstract text is available yet for this article.
December 2012: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/22220502/a-brief-survey-to-characterize-oxycodone-abuse-patterns-in-adolescents-enrolled-in-two-substance-abuse-recovery-high-schools
#20
Eric D Osgood, Thomas A Eaton, Jeremiah J Trudeau, Nathaniel P Katz
BACKGROUND: Although oxycodone is one of the most widely available and abused opioids, little published information exists on the abuse of immediate-release oxycodone. OBJECTIVE: To obtain information on abuse of oxycodone and the effectiveness of abuse-deterrent strategies, especially for immediate-release oxycodone, we surveyed oxycodone abuse patterns in a population of experienced opioid abusers. METHODS: Students or recent graduates of two substance abuse recovery high schools in Massachusetts were surveyed on abuse behaviors with short-acting single-entity oxycodone (e...
March 2012: American Journal of Drug and Alcohol Abuse
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