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Severe chronic pain

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https://www.readbyqxmd.com/read/29220782/mindfulness-based-interventions-for-chronic-pain-evidence-and-applications
#1
REVIEW
Muhammad Hassan Majeed, Ali Ahsan Ali, Donna M Sudak
Chronic pain is estimated to occur in from 5.5% to 33% of the world's adult population (Gureje et al., 1998). Chronic pain is frequently treated with opiates, which has produced an opiate addiction crisis (Dowell et al., 2016). Several non-pharmacological treatment alternatives can help manage chronic pain. There is moderate evidence that mindfulness-based interventions (MBIs) such as meditation, yoga, and stress reduction lower the perception of pain, increase mobility, improve functioning and well-being. By integrating MBIs and other therapeutic interventions in a multi-disciplinary pain management plan, clinicians can improve treatment outcomes and potentially decrease pain-related medication utilization...
December 5, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29218068/prostheses-used-in-laparoscopic-inguinal-hernia-repair-biocompatibility-postoperative-complications-and-quality-of-life-review-of-the-literature
#2
Alexandra Florina Trandafir, Dorin Eugen Popa, Danut Vasile
INTRODUCTION: There is a continuous concern about meshes used in laparoscopic inguinal hernia repair, which mainly relates to their biocompatibility and ability to decrease postoperative complications and recurrence rate; in other words, efforts are made to find the "ideal" prosthesis. OBJECTIVES: To evaluate different prostheses used in laparoscopic inguinal hernia repair in terms of biocompatibility, postoperative complications, recurrence rate and quality of life, so that all the features could lead us to the "ideal" mesh...
September 2017: Mædica
https://www.readbyqxmd.com/read/29215841/-histamine-metabolism-disorder-in-pathogenesis-of-chronic-pelvic-pain-in-patients-with-external-genital-endometriosis
#3
M R Orazov, V Y Radzinskiy, M B Khamoshina, E N Nosenko, E S Tokaeva, L K Barsegyan, Y R Zakirova
Objective. To study features of histamine metabolism in patients with chronic pelvic pain associated with external genital endometriosis. Methods. For quantitative assessment of histamine level in peripheral blood was taken from 100 patients which than was centrifuged. In blood serum histamine concentration was determined by enzyme-linked immunosorbent assay method with reagents «Histamine ЕLISA» on the machine BAE-1000 Histamine (Labor Diagnostika Nord - LDN, Hermany). A pain syndrome was assessed by Visual Analog Scale (VAS), quality of life assessment - by Endometriosis Health Profile Questionnaire (EHR-30), level of anxiety was determined by Spielberger-Khanin questionnaire...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29215605/cone-snails-a-big-store-of-conotoxins-for-novel-drug-discovery
#4
REVIEW
Bingmiao Gao, Chao Peng, Jiaan Yang, Yunhai Yi, Junqing Zhang, Qiong Shi
Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery. These venomous snails capture prey using a diverse array of unique bioactive neurotoxins, usually named as conotoxins or conopeptides. These conotoxins have proven to be valuable pharmacological probes and potential drugs due to their high specificity and affinity to ion channels, receptors, and transporters in the nervous systems of target prey and humans...
December 7, 2017: Toxins
https://www.readbyqxmd.com/read/29214679/the-relationship-between-negative-metacognitive-thoughts-pain-catastrophizing-and-adjustment-to-chronic-pain
#5
M S Ziadni, J A Sturgeon, B D Darnall
BACKGROUND: Cognitive appraisals, most notably pain catastrophizing, play an important role in chronic pain. The role of metacognition and its impact on the relationship between pain catastrophizing and health are understudied. The identification of metacognition as a moderator of psychological constructs may have clinical and empirical implications. We hypothesized that negative metacognitive beliefs would moderate the relationships between pain catastrophizing and emotional functioning and physical activity...
December 7, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29211026/a-review-of-chronic-pain-and-cognitive-mood-and-motor-dysfunction-following-mild-traumatic-brain-injury-complex-comorbid-and-or-overlapping-conditions
#6
REVIEW
Ramesh Grandhi, Samon Tavakoli, Catherine Ortega, Maureen J Simmonds
Mild traumatic brain injury (mTBI) is commonly encountered in clinical practice. While the cognitive ramifications of mTBI are frequently described in the literature, the impact of mTBI on emotional, sensory, and motor function is not as commonly discussed. Chronic pain is a phenomenon more prevalent among patients with mTBI compared to those with moderate or severe traumatic brain injury. Chronic pain can become a primary disorder of the central nervous system (CNS) expressed as widespread pain, and cognitive, mood, and movement dysfunction...
December 6, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29210789/predicting-severity-of-acute-pain-after-cesarean-delivery-a-narrative-review
#7
Brock H Gamez, Ashraf S Habib
Cesarean delivery is one of the most common surgical procedures in the United States, with over 1.3 million performed annually. One-fifth of women who undergo cesarean delivery will experience severe pain in the acute postoperative period, increasing their risk of developing chronic pain and postpartum depression, and negatively impacting breastfeeding and newborn care. A growing body of research has investigated tools to predict which patients will experience more severe pain and have increased analgesic consumption after cesarean delivery...
November 22, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29210461/chronic-pain-in-pachyonychia-congenita-evidence-for-neuropathic-origin
#8
S Brill, E Sprecher, F J D Smith, N Geva, H Gruener, H Nahman-Averbuch, R Defrin
BACKGROUND: Pachyonychia congenita (PC) is a rare autosomal dominant skin disease with chronic pain being the most prominent complaint. Histological studies showing alterations in sensory innervation along with few reports on alterations in mechanical sensitivity suggest that PC may be a form of neuropathy. OBJECTIVE: To systematically evaluate sensory function of PC patients vs. controls, here for the first time, in order to investigate PC pathophysiology. METHODS: Patients (n=62) and controls (n=45) completed the McGill and Douleur Neuropathique-4 (DN4) questionnaires...
December 6, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29207909/the-evolving-role-of-long-term-pharmacotherapy-for-opioid-induced-constipation-in-patients-being-treated-for-noncancer-pain
#9
Brandi L Bowers, Andrew J Crannage
Nationally, the prescription of opioids for acute and chronic pain is increasing. As opioid use continues to expand and become of increased concern for health-care practitioners, so do the adverse effects and long-term management of those effects. Opioid-induced constipation (OIC) presents a unique challenge because tolerance does not develop to this particular adverse effect, making chronic pain management a delicate balance between relieving pain and preventing long-term adverse effects such as constipation and dependence...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29205996/current-management-of-ovarian-endometriomas
#10
Ludovico Muzii, Chiara DI Tucci, Daniele DI Mascio, Mara DI Feliciantonio, Oriana Capri, Daniela Pietrangeli, Francesco Rech, Pierluigi Benedetti Panici
The choice of treatment in case of ovarian endometriomas is one of the most discussed topics in Reproductive Medicine. Management options include expectancy, medical treatment, surgery, in-vitro fertilization (IVF), or a combination of the above. The main presenting symptom, i.e. pain or infertility, usually guide the choice of treatment. Medical treatment is usually preferred as the first line option when pain is the associated symptom, whereas surgery or IVF are preferred in case of associated infertility...
December 4, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29205874/establishment-of-experimental-autoimmune-prostatitis-model-by-t2-peptide-in-aluminium-hydroxide-adjuvant
#11
L Zhang, A U Ihsan, Y Cao, Y Cheng, X Zhou
A mouse model was developed to simulate the clinical features of chronic prostatitis/chronic pelvic pain syndrome using peptide (T2 ). Forty C57BL/6 mice were divided into four groups of 10 mice each, averagely and randomly. T2 plus aluminium hydroxide adjuvant group was given subcutaneous injection with the emulsion mixture of T2 and aluminium hydroxide adjuvant, the T2 group with T2 , the aluminium hydroxide adjuvant group with aluminium hydroxide adjuvant and the normal control group with 0.9/% NaCl solution...
December 4, 2017: Andrologia
https://www.readbyqxmd.com/read/29205015/treatment-options-for-acute-mesenteric-ischemia-have-improved
#12
Jussi M Kärkkäinen, Hannu Manninen, Hannu Paajanen
Acute mesenteric ischemia resulting from mesenteric arterial thrombosis is a life-threatening cardiovascular complication with symptoms ranging from sudden-onset abdominal pain to vague symptoms of several days' duration. Although contrast-enhanced computed tomography is an excellent diagnostic tool, detection of the disease before the development of permanent intestinal injury is still difficult. Endovascular treatment is usually successful in restoring intestinal blood flow acutely. Chronic mesenteric ischemia requires urgent detection and therapy in order to prevent irreversible intestinal ischemia...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29204950/-physiotherapy-in-pain-medicine-further-treatment-after-a-multimodal-pain-therapy-program
#13
Elisabeth Dean
BACKGROUND: Chronic pain is a global health challenge for both the individual patient and the healthcare community. Multimodal Pain Management, as one of the possible therapies for patients with chronic pain, provides a comprehensive tool that places equally high demands on therapists and patients and is consistently recommended. METHOD: In a monocentric cross-sectional study, patients who had previously participated in a multi-modal pain therapy program lasting several weeks were asked about the follow-up recommendations of the interdisciplinary team of the Pain Management Clinic...
December 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/29203308/magnetic-resonance-imaging-undetectable-epiduroscopic-hotspot-in-chronic-discogenic-back-pain-does-sinuvertebral-neuropathy-actually-exists
#14
Sung Ho Choi, Nitin Adsul, Hyeun Sung Kim, Jee-Soo Jang, Il-Tae Jang, Seong-Hoon Oh
BACKGROUND: The causes of chronic discogenic back pain have not yet been clearly identified. Neural ingrowth around the annulus is widely considered to be one of the possible cause. However, neuropathy around the annulus has yet to be observed visually. We report a case of a hotspot that was observed in an epiduroscopic view, but not in imaging findings. CASE DESCRIPTION: A 46-year-old woman was admitted with pain in the back, left buttock, and posterior thigh for 2 years...
December 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29202845/robotic-assisted-gait-as-a-tool-for-rehabilitation-of-individuals-with-spinal-cord-injury-a-systematic-review
#15
REVIEW
Ledycnarf J Holanda, Patrícia M M Silva, Thiago C Amorim, Matheus O Lacerda, Camila R Simão, Edgard Morya
BACKGROUND: Spinal cord injury (SCI) is characterized by a total or partial deficit of sensory and motor pathways. Impairments of this injury compromise muscle recruitment and motor planning, thus reducing functional capacity. SCI patients commonly present psychological, intestinal, urinary, osteomioarticular, tegumentary, cardiorespiratory and neural alterations that aggravate in chronic phase. One of the neurorehabilitation goals is the restoration of these abilities by favoring improvement in the quality of life and functional independence...
December 4, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29201359/rationale-for-and-approach-to-preoperative-opioid-weaning-a-preoperative-optimization-protocol
#16
REVIEW
Heath McAnally
The practice of chronic opioid prescription for chronic non-cancer pain has come under considerable scrutiny within the past several years as mounting evidence reveals a generally unfavorable risk to benefit ratio and the nation reels from the grim mortality statistics associated with the opioid epidemic. Patients struggling with chronic pain tend to use opioids and also seek out operative intervention for their complaints, which combination may be leading to increased postoperative "acute-on-chronic" pain and fueling worsened chronic pain and opioid dependence...
2017: Perioperative Medicine
https://www.readbyqxmd.com/read/29201287/does-size-really-matter-a-multisite-study-assessing-the-latent-structure-of-the-proposed-icd-11-and-dsm-5-diagnostic-criteria-for-ptsd
#17
Maj Hansen, Philip Hyland, Karen-Inge Karstoft, Henrik B Vaegter, Rikke H Bramsen, Anni B S Nielsen, Cherie Armour, Søren B Andersen, Mette Terp Høybye, Simone Kongshøj Larsen, Tonny E Andersen
Background: Researchers and clinicians within the field of trauma have to choose between different diagnostic descriptions of posttraumatic stress disorder (PTSD) in the DSM-5 and the proposed ICD-11. Several studies support different competing models of the PTSD structure according to both diagnostic systems; however, findings show that the choice of diagnostic systems can affect the estimated prevalence rates. Objectives: The present study aimed to investigate the potential impact of using a large (i.e. the DSM-5) compared to a small (i...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29199587/liposome-based-nanomedicine-therapeutics-for-rheumatoid-arthritis
#18
Mahfoozur Rahman, Sarwar Beg, Firoz Anwar, Vikas Kumar, Ruhi Ubale, Richard T Addo, Raisuddin Ali, Sohail Akhter
Rheumatoid arthritis (RA) is a very painful severe autoimmune disease with complex pathology characterized by progressive chronic inflammation, and devastation of the synovium, cartilage, and other joint-associated structures. Significant advances in research in the area of pathophysiology, diagnosis, drug development, and targeted delivery have led to improved RA therapy and better patient compliance. Targeted drug delivery using liposomal nanomedicines significantly alleviate the challenges with conventional anti-RA medications such as off-target effects, short biological half-life, poor bioavailability, high dose-related toxicity, etc...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29197987/surgery-in-adenomyosis
#19
Marco Aurelio Pinho Oliveira, Claudio Peixoto Crispi, Leila Cristina Brollo, Claudio Peixoto Crispi, Rudy Leon De Wilde
INTRODUCTION: Adenomyosis is defined as the presence of endometrial glands and stroma within the myometrium. The true prevalence is unknown and has been reported to range from 1 to 70%. It has a significantly negative impact on women's quality of life, causing abnormal uterine bleeding, dysmenorrhea, and chronic pelvic pain. The definitive treatment for adenomyosis is hysterectomy, although it does not contemplate patients who wish to preserve their fertility. The aim of this paper is to discuss the latest evidence on the surgical techniques for the treatment of adenomyosis published in medical-scientific databases...
December 2, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29197621/inhibition-of-histone-deacetylase-6-hdac6-protects-against-vincristine-induced-peripheral-neuropathies-and-inhibits-tumor-growth
#20
Lawrence Van Helleputte, Mandy Kater, Dana P Cook, Caroline Eykens, Elisabeth Rossaert, Wanda Haeck, Tom Jaspers, Natasja Geens, Pieter Vanden Berghe, Conny Gysemans, Chantal Mathieu, Wim Robberecht, Philip Van Damme, Guido Cavaletti, Matthew Jarpe, Ludo Van Den Bosch
As cancer is becoming more and more a chronic disease, a large proportion of patients is confronted with devastating side effects of certain anti-cancer drugs. The most common neurological complications are painful peripheral neuropathies. Chemotherapeutics that interfere with microtubules, including plant-derived vinca-alkaloids such as vincristine, can cause these chemotherapy-induced peripheral neuropathies (CIPN). Available treatments focus on symptom alleviation and pain reduction rather than prevention of the neuropathy...
November 29, 2017: Neurobiology of Disease
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