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Remzi Dogan, Sabri Baki Eren, Ozge Gedik, Alper Yenıgun, Mehmet Serif Aydın, Busranur Eser, Orhan Ozturan
OBJECTIVE: The use of Mesna as a chemical dissector in higher concentrations may reduce the length of time of operation by providing more effective dissection as well as being used in otologic pathologies such as tympanosclerosis. In this study, it was aimed to assess the effect of Mesna on the internal ear, which was applied intra-tympanically in higher concentrations than the conventional use. METHODS: Twenty-four female rats were included in our study. The rats were randomly divided into three groups (Group 1: Mesna 50%, Group 2: Mesna 100%, Group 3: Saline)...
June 2018: International Journal of Pediatric Otorhinolaryngology
Jorge C Kattah
Background: Previous series of bilateral vestibular loss (BVL) identified numerous etiologies, but surprisingly, a cause in a significant number of cases remains unknown. In an effort to understand possible etiology and management strategies, a global effort is currently in progress. Here, I contribute my 10-year experience with both acute and chronic BVL during the 2007-2017 decade. Methods: This is a retrospective review of the charts and EMR of patients diagnosed with BVL in the last 10 years...
2018: Frontiers in Neurology
Min Jae Kim, Kyung Wook Heo, Pil Hyun Jeon, Jae Jun Lee, Jun Ho Lee
OBJECTIVES: The purpose of this study was to determine the prognostic potential of admission of a patient for idiopathic sudden sensorineural hearing loss (ISSNHL). STUDY DESIGN: Retrospective clinical study. METHODS: We conducted a retrospective study of 301 patients with ISSNHL. The patients were divided into a study (57 patients at out-patients department (OPD) based treatment, using systemic steroids and intra-tympanic (IT) steroid injection) and a control groups (301 patients at admission, using systemic steroids and IT steroid injection)...
April 2018: Acta Oto-laryngologica
Mehrdad Rogha, Amin Kalkoo
INTRODUCTION: Hearing loss is fairly a common disorder which is usually treated with corticosteroids via systemic administration and/or intra-tympanic injection. This study aimed to compare the effectiveness of intra-tympanic injections of dexamethasone with its combination with hyaluronic acid in patients with sudden sensorineural hearing loss. MATERIALS AND METHODS: In this clinical trial, 40 patients were randomly assigned to two groups; in the first group, 20 patients received 2...
September 2017: Iranian Journal of Otorhinolaryngology
Bharath Ramaswamy, Soumen Roy, Andrea B Apolo, Benjamin Shapiro, Didier A Depireux
Cisplatin (cis-diamminedichloroplatinum) is widely used as a chemotherapeutic drug for genitourinary, breast, lung and head and neck cancers. Though effective in inducing apoptosis in cancer cells, cisplatin treatment causes severe hearing loss among patients. Steroids have been shown to mitigate cisplatin-induced hearing loss. However, steroids may interfere with the anti-cancer properties of cisplatin if administered systemically, or are rapidly cleared from the middle and inner ear and hence lack effectiveness when administered intra-tympanically...
2017: Frontiers in Cellular Neuroscience
Irfan Ul Shamas
INTRODUCTION: The role of this study was to evaluate the effectiveness of intra tympanic administration of Gentamicin(40 mgs/ml) and Dexamethasone 0.5 ml(4 mgs/ml) on hearing and tinnitus of patients who had recurrent acute attacks of vertigo, tinnitus and hearing loss. STUDY DESIGN: 60 consecutive patients of Meniere's disease were randomly divided into 3 groups of twenty patients each. Group A included 20 patients who received intra tympanic gentamicin, Group B included 20 patients who received intra tympanic dexamethasone and Group C included 20 patients who received intra tympanic normal saline 0...
June 1, 2017: International Tinnitus Journal
Sainan Zhang, Yuqing Zhao
Dammarane triterpenoids are widely distributed in plants and are implicated in various bioactivities and pharmacological effects. This review focuses on advancements in dammarane triterpenoid metabolism, particularly drug design and development, including radiolabeling, absorption, distribution, metabolism, excretion, and pharmacokinetics, which can accurately describe the behaviors of dammarane triterpenoids. This review contributes to the systematic and consistent research and development of dammarane triterpenoids...
2016: Current Drug Metabolism
Yangming Leng, Bo Liu, Renhong Zhou, Jingjing Liu, Dongdong Liu, Su-Lin Zhang, Wei-Jia Kong
CONCLUSION: Intra-tympanic dexamethasone injection (ITD) could serve as a first-line intra-tympanic (IT) treatment for Meniere's disease (MD), regardless of hearing level. Even if the response to initial ITD course was unsatisfactory, a repeated course may be beneficial with some patients. OBJECTIVES: This study examined the effect of repeated courses of ITD administered on demand and investigated the possibility of ITD as an initial IT treatment for medically intractable MD patients...
February 2017: Acta Oto-laryngologica
Sanja Ramirez, Travis Allen, Lindsay Villagracia, Yooree Chae, Jan M Ramirez, Daniel D Rubens
Infants that succumb to Sudden Infant Death Syndrome (SIDS) have been identified with inner ear dysfunction (IED) at birth and on autopsy. We previously investigated whether IED could play a mechanistic role in SIDS. We discovered that animals with IED displayed significant suppression of movement arousal to a hypoxic-hypercarbic gas mixture under light anesthesia. In the current study we investigated the role of each gas in triggering movements and the response to hypercarbia during natural sleep without anesthesia...
November 19, 2016: Neuroscience
Hong Liu, Ting Zhang, Qianru Wu, Yibo Zhang, Chunfu Dai
CONCLUSIONS: One-shot, low-dose intra-tympanic gentamicin (ITG) treatment was effective and safe for Ménière's disease (MD) patients. Head thrust test (HTT) and vestibular evoked myogenic potentials (VEMPs) test could be used as endpoint indicators for vertigo control in MD patients. OBJECTIVES: The present study is to explore end-point indicators of ITG injection in MD. METHODS: Patients with MD were reviewed from June 2012 to March 2014...
February 2017: Acta Oto-laryngologica
Hiroshi Nonoyama, Tohru Tanigawa, Rei Shibata, Hirokazu Tanaka, Nobuyuki Katahira, Yuichiro Horibe, Keiji Takemura, Kenta Murotani, Norio Ozeki, Hiromi Ueda
CONCLUSION: In the mouse, when a tympanic perforation is present, gadoteridol does not seem to cause ototoxicity. Gadodiamide may cause mild ototoxicity other than toxicity to the outer hair cells of the cochlea. OBJECTIVES: Endolymphatic hydrops have been visualized through intra-tympanic injection of gadolinium-based contrast agents (GBCAs) and three-dimensional fluid-attenuated inversion recovery (3-D FLAIR) magnetic resonance imaging. However, reports on the safety of GBCAs are limited...
November 2016: Acta Oto-laryngologica
Eusebi Matiñó-Soler, Jorge Rey-Martinez, Gabriel Trinidad-Ruiz, Angel Batuecas-Caletrio, Nicolás Pérez Fernández
CONCLUSION: VOR adaptation and organization of refixation saccades in a gathered pattern is a process that can be artificially induced in patients with unilateral vestibular loss who have not developed it naturally, improving imbalance and vestibular disability. OBJECTIVE: To test that temporary grouping of refixation saccades should be linked to better clinical status without gain recovery. METHODS: A training to induce the refixation saccades into gathered fashion is performed...
September 2016: Acta Oto-laryngologica
Hamed Yazdanshenas, Anousheh Ashouri, Galen Kaufman
Introduction Unilateral labyrinthectomy and intra-tympanic gentamycin have been employed in the treatment of Ménière's disease, but the efficacy of these techniques has not been well established. Objective The objective of this study is to measure the time course of recovery from a unilateral labyrinthectomy either after ipsilateral topical treatment with gentamicin to the inner ear or without the previous insult. Methods Twenty-nine adult Mongolian gerbils were randomized into two experimental groups...
April 2016: International Archives of Otorhinolaryngology
Arnaud P J Giese, Jess G Guarnaschelli, Jonette A Ward, Daniel I Choo, Saima Riazuddin, Zubair M Ahmed
Radiotherapy of individuals suffering with head & neck or brain tumors subserve the risk of sensorineural hearing loss. Here, we evaluated the protective effect of Aminothiol PrC-210 (3-(methyl-amino)-2-((methylamino)methyl)propane-1-thiol) on the irradiated inner ear of guinea pigs. An intra-peritoneal or intra-tympanic dose of PrC-210 was administered prior to receiving a dose of gamma radiation (3000 cGy) to each ear. Auditory Brainstem Responses (ABRs) were recorded one week and two weeks after the radiation and compared with the sham animal group...
2015: PloS One
Ah Ra Jung, Myung Gu Kim, Sung Su Kim, Sang Hoon Kim, Seung Geun Yeo
CONCLUSION: Factors prognostic of recovery from low frequency sensorineural hearing loss without vertigo are co-occurrence of tinnitus, PTA determined hearing level on the affected side before treatment initiation, and time from onset to treatment initiation. The rate of hearing recovery was higher in the oral steroid than in the intra-tympanic steroid and combined groups. OBJECTIVES: Although many studies have assessed acute sudden hearing loss, few have analyzed low-frequency hearing loss...
2016: Acta Oto-laryngologica
Cristina Zulueta-Santos, Óscar Dorado Berumen, Raquel Manrique-Huarte, Nicolás Pérez-Fernández
CONCLUSION: The low clinical efficacy of the treatment for patients included in this work correlates with no noticeable effect on the vestibular function. OBJECTIVE: To assess follow-up in patients with idiopathic and secondary Ménière's disease after treatment with intra-tympanic dexamethasone and correlate clinical findings with changes in the vestibular-ocular reflex elicited after stimulation of each of the six semicircular canals. METHODS: This is a single center retrospective review of patients presenting the clinical symptomatology of Meniérè's disease treated with intra-tympanic dexamethasone...
2015: Acta Oto-laryngologica
Giuseppe Attanasio, Edoardo Covelli, Laura Cagnoni, Eleonora Masci, Davide Rosati, Edoardo Di Porto, Maurizio Barbara, Simonetta Monini, Roberto Filipo
CONCLUSIONS: The present study shows that AGE, DELAY, and PTA_PRE may be considered factors influencing therapeutic success in intra-tympanic steroid therapy. OBJECTIVE: The aim of the study is to evaluate the relationship between the therapeutic success of intra-tympanic prednisolone therapy and age, in patients affected by idiopathic sudden sensorineural hearing loss (ISSNHL), considering the influence of factors such as delay, gender, and pure tone average (PTA) pre-therapy...
2015: Acta Oto-laryngologica
Cecilia Engmér Berglin, Pernilla Videhult Pierre, Andreas Ekborn, Tobias Bramer, Katarina Edsman, Malou Hultcrantz, Göran Laurell
CONCLUSION: A formulation based on sodium hyaluronate (NaHYA) was the most promising candidate vehicle for intra-tympanic drug administration regarding conductive hearing loss, inflammatory reactions, and elimination. OBJECTIVES: Recent advances in inner ear research support the idea of using the middle ear cavity for drug administration to target the inner ear. This paper presents rheological and safety assessments of three candidate polymer formulations for intra-tympanic drug administration...
2015: Acta Oto-laryngologica
Günay Kozan, Bülent Aktan, Muhammed Sedat Sakat, Sezgin Kurt, Fatih Öner, Adem Kara
CONCLUSION: The results of the study showed that clarithromycin has anti-inflammatory and antioxidant effects and, when it is combined with prednisolone, those effects gain strength. OBJECTIVES: The present study aims to investigate the effects that the antioxidant and anti-inflammatory activities of clarithromycin and/or prednisolone have on experimental otitis media in effusion-induced guinea-pigs. METHOD AND RESULTS: In this study, 35-male guinea pigs were randomly divided into five-groups...
2015: Acta Oto-laryngologica
Jin Yan, Liyan Peng, Hongzheng Cheng, Yonghua Cui, Aiguo Liu
OBJECTIVE: To evaluate the extent of endolymphatic hydrops as shown by three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D FLAIR MRI) performed 24 hours after bilateral intratympanic gadolinium administration and discuss the positive rate of endolymphatic hydrops in vestibule and cochlea. METHOD: Twenty-four hours after bilateral intra-tympanic 8 times diluted gadolinium administration, three-dimensional fluid-attenuated inversion recovery MRI, using a three-Tesla unit, was performed in 48 patients, and then assessed the extent of endolymphatic hydrops in the MRI images...
March 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
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