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https://www.readbyqxmd.com/read/27697027/drug-metabolism-and-pharmacokinetics-of-dammarane-triterpenoids
#1
Sainan Zhanga, Yuqing Zhao
Dammarane triterpenoids are widely distributed in plants and possess various bioactivities and pharmacological effects. In this review, we focus on the advances in drug metabolism of dammarane triterpenoids, particularly from the aspect of drug design and development, including radiolabel, absorption (A), distribution (D), metabolism (M), excretion (E), pharmacokinetics (PK), which could describe behaviors of dammarane triterpenoids more accurately, and were helpful for the systematic and consistent research and development of dammarane triterpenoids...
October 3, 2016: Current Drug Metabolism
https://www.readbyqxmd.com/read/27650470/repeated-courses-of-intratympanic-dexamethasone-injection-are-effective-for-intractable-meniere-s-disease
#2
Yangming Leng, Bo Liu, Renhong Zhou, Jingjing Liu, Dongdong Liu, Su-Lin Zhang, Wei-Jia Kong
CONCLUSION: Intra-tympanic dexamethasone injection (ITD) could serve as a first-line intra-tympanic (IT) treatment for Meniere's disease (MD), regardless of hearing level. Even if the response to initial ITD course was unsatisfactory, a repeated course may be beneficial with some patients. OBJECTIVES: This study examined the effect of repeated courses of ITD administered on demand and investigated the possibility of ITD as an initial IT treatment for medically intractable MD patients...
September 21, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27634772/inner-ear-lesion-and-the-differential-roles-of-hypoxia-and-hypercarbia-in-triggering-active-movements-potential-implication-for-the-sudden-infant-death-syndrome
#3
Sanja Ramirez, Travis Allen, Lindsay Villagracia, Yooree Chae, Jan M Ramirez, Daniel D Rubens
Infants that succumb to Sudden Infant Death Syndrome (SIDS) have been identified with inner ear dysfunction (IED) at birth and on autopsy. We previously investigated whether IED could play a mechanistic role in SIDS. We discovered that animals with IED displayed significant suppression of movement arousal to a hypoxic-hypercarbic gas mixture under light anesthesia. In the current study we investigated the role of each gas in triggering movements and the response to hypercarbia during natural sleep without anesthesia...
September 12, 2016: Neuroscience
https://www.readbyqxmd.com/read/27608722/end-point-indicators-of-low-dose-intra-tympanic-gentamicin-in-management-of-m%C3%A3-ni%C3%A3-re-s-disease
#4
Hong Liu, Ting Zhang, Qianru Wu, Yibo Zhang, Chunfu Dai
CONCLUSIONS: One-shot, low-dose intra-tympanic gentamicin (ITG) treatment was effective and safe for Ménière's disease (MD) patients. Head thrust test (HTT) and vestibular evoked myogenic potentials (VEMPs) test could be used as endpoint indicators for vertigo control in MD patients. OBJECTIVES: The present study is to explore end-point indicators of ITG injection in MD. METHODS: Patients with MD were reviewed from June 2012 to March 2014...
September 9, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27315460/investigation-of-the-ototoxicity-of-gadoteridol-prohance-and-gadodiamide-omniscan-in-mice
#5
Hiroshi Nonoyama, Tohru Tanigawa, Rei Shibata, Hirokazu Tanaka, Nobuyuki Katahira, Yuichiro Horibe, Keiji Takemura, Kenta Murotani, Norio Ozeki, Hiromi Ueda
CONCLUSION: In the mouse, when a tympanic perforation is present, gadoteridol does not seem to cause ototoxicity. Gadodiamide may cause mild ototoxicity other than toxicity to the outer hair cells of the cochlea. OBJECTIVES: Endolymphatic hydrops have been visualized through intra-tympanic injection of gadolinium-based contrast agents (GBCAs) and three-dimensional fluid-attenuated inversion recovery (3-D FLAIR) magnetic resonance imaging. However, reports on the safety of GBCAs are limited...
June 17, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27109262/a-new-method-to-improve-the-imbalance-in-chronic-unilateral-vestibular-loss-the-organization-of-refixation-saccades
#6
Eusebi Matiñó-Soler, Jorge Rey-Martinez, Gabriel Trinidad-Ruiz, Angel Batuecas-Caletrio, Nicolás Pérez Fernández
CONCLUSION: VOR adaptation and organization of refixation saccades in a gathered pattern is a process that can be artificially induced in patients with unilateral vestibular loss who have not developed it naturally, improving imbalance and vestibular disability. OBJECTIVE: To test that temporary grouping of refixation saccades should be linked to better clinical status without gain recovery. METHODS: A training to induce the refixation saccades into gathered fashion is performed...
September 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27096015/neurovestibular-compensation-following-ototoxic-lesion-and-labyrinthectomy
#7
Hamed Yazdanshenas, Anousheh Ashouri, Galen Kaufman
Introduction Unilateral labyrinthectomy and intra-tympanic gentamycin have been employed in the treatment of Ménière's disease, but the efficacy of these techniques has not been well established. Objective The objective of this study is to measure the time course of recovery from a unilateral labyrinthectomy either after ipsilateral topical treatment with gentamicin to the inner ear or without the previous insult. Methods Twenty-nine adult Mongolian gerbils were randomized into two experimental groups...
April 2016: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/26599238/radioprotective-effect-of-aminothiol-prc-210-on-irradiated-inner-ear-of-guinea-pig
#8
Arnaud P J Giese, Jess G Guarnaschelli, Jonette A Ward, Daniel I Choo, Saima Riazuddin, Zubair M Ahmed
Radiotherapy of individuals suffering with head & neck or brain tumors subserve the risk of sensorineural hearing loss. Here, we evaluated the protective effect of Aminothiol PrC-210 (3-(methyl-amino)-2-((methylamino)methyl)propane-1-thiol) on the irradiated inner ear of guinea pigs. An intra-peritoneal or intra-tympanic dose of PrC-210 was administered prior to receiving a dose of gamma radiation (3000 cGy) to each ear. Auditory Brainstem Responses (ABRs) were recorded one week and two weeks after the radiation and compared with the sham animal group...
2015: PloS One
https://www.readbyqxmd.com/read/26479582/clinical-characteristics-and-prognosis-of-low-frequency-sensorineural-hearing-loss-without-vertigo
#9
Ah Ra Jung, Myung Gu Kim, Sung Su Kim, Sang Hoon Kim, Seung Geun Yeo
CONCLUSION: Factors prognostic of recovery from low frequency sensorineural hearing loss without vertigo are co-occurrence of tinnitus, PTA determined hearing level on the affected side before treatment initiation, and time from onset to treatment initiation. The rate of hearing recovery was higher in the oral steroid than in the intra-tympanic steroid and combined groups. OBJECTIVES: Although many studies have assessed acute sudden hearing loss, few have analyzed low-frequency hearing loss...
2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/26245894/the-effect-of-intra-tympanic-dexamethasone-on-the-vestibular-function-in-patients-with-recurrent-vertigo
#10
RANDOMIZED CONTROLLED TRIAL
Cristina Zulueta-Santos, Óscar Dorado Berumen, Raquel Manrique-Huarte, Nicolás Pérez-Fernández
CONCLUSION: The low clinical efficacy of the treatment for patients included in this work correlates with no noticeable effect on the vestibular function. OBJECTIVE: To assess follow-up in patients with idiopathic and secondary Ménière's disease after treatment with intra-tympanic dexamethasone and correlate clinical findings with changes in the vestibular-ocular reflex elicited after stimulation of each of the six semicircular canals. METHODS: This is a single center retrospective review of patients presenting the clinical symptomatology of Meniérè's disease treated with intra-tympanic dexamethasone...
2015: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/26204857/does-age-influence-the-success-of-intra-tympanic-steroid-treatment-in-idiopathic-sudden-deafness
#11
Giuseppe Attanasio, Edoardo Covelli, Laura Cagnoni, Eleonora Masci, Davide Rosati, Edoardo Di Porto, Maurizio Barbara, Simonetta Monini, Roberto Filipo
CONCLUSIONS: The present study shows that AGE, DELAY, and PTA_PRE may be considered factors influencing therapeutic success in intra-tympanic steroid therapy. OBJECTIVE: The aim of the study is to evaluate the relationship between the therapeutic success of intra-tympanic prednisolone therapy and age, in patients affected by idiopathic sudden sensorineural hearing loss (ISSNHL), considering the influence of factors such as delay, gender, and pure tone average (PTA) pre-therapy...
2015: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/26146023/local-treatment-of-the-inner-ear-a-study-of-three-different-polymers-aimed-for-middle-ear-administration
#12
Cecilia Engmér Berglin, Pernilla Videhult Pierre, Andreas Ekborn, Tobias Bramer, Katarina Edsman, Malou Hultcrantz, Göran Laurell
CONCLUSION: A formulation based on sodium hyaluronate (NaHYA) was the most promising candidate vehicle for intra-tympanic drug administration regarding conductive hearing loss, inflammatory reactions, and elimination. OBJECTIVES: Recent advances in inner ear research support the idea of using the middle ear cavity for drug administration to target the inner ear. This paper presents rheological and safety assessments of three candidate polymer formulations for intra-tympanic drug administration...
2015: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/26143935/effect-of-systemic-clarithromycin-and-prednisolone-on-histamine-induced-otitis-media-in-guinea-pigs
#13
Günay Kozan, Bülent Aktan, Muhammed Sedat Sakat, Sezgin Kurt, Fatih Öner, Adem Kara
CONCLUSION: The results of the study showed that clarithromycin has anti-inflammatory and antioxidant effects and, when it is combined with prednisolone, those effects gain strength. OBJECTIVES: The present study aims to investigate the effects that the antioxidant and anti-inflammatory activities of clarithromycin and/or prednisolone have on experimental otitis media in effusion-induced guinea-pigs. METHOD AND RESULTS: In this study, 35-male guinea pigs were randomly divided into five-groups...
2015: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/26103661/-detection-and-grading-of-endolymphatic-hydrops-in-m%C3%A3-ni%C3%A3-re-s-disease-using-3d-flair-mri
#14
Jin Yan, Liyan Peng, Hongzheng Cheng, Yonghua Cui, Aiguo Liu
OBJECTIVE: To evaluate the extent of endolymphatic hydrops as shown by three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D FLAIR MRI) performed 24 hours after bilateral intratympanic gadolinium administration and discuss the positive rate of endolymphatic hydrops in vestibule and cochlea. METHOD: Twenty-four hours after bilateral intra-tympanic 8 times diluted gadolinium administration, three-dimensional fluid-attenuated inversion recovery MRI, using a three-Tesla unit, was performed in 48 patients, and then assessed the extent of endolymphatic hydrops in the MRI images...
March 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/26094970/changes-in-endolymphatic-hydrops-in-patients-with-m%C3%A3-ni%C3%A3-re-s-disease-treated-conservatively-for-more-than-1-year
#15
Kenji Suga, Masahiro Kato, Tadao Yoshida, Naoki Nishio, Takafumi Nakada, Saiko Sugiura, Hironao Otake, Ken Kato, Masaaki Teranishi, Michihiko Sone, Shinji Naganawa, Tsutomu Nakashima
CONCLUSION: This study revealed that endolymphatic hydrops (EH) reduced in some cases with Ménière's disease (MD) treated conservatively. It appears that the EH reduction was associated with improvement of the clinical symptoms. OBJECTIVES: The relationship between the degree of EH and clinical symptoms is not clear at present. The purpose of the present study was to investigate the time course of the relationship in patients with MD treated conservatively. PATIENTS: Twelve patients with MD treated conservatively for more than 1 year in a university hospital...
September 2015: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/25973683/xbp1-mitigates-aminoglycoside-induced-endoplasmic-reticulum-stress-and-neuronal-cell-death
#16
N Oishi, S Duscha, H Boukari, M Meyer, J Xie, G Wei, T Schrepfer, B Roschitzki, E C Boettger, J Schacht
Here we study links between aminoglycoside-induced mistranslation, protein misfolding and neuropathy. We demonstrate that aminoglycosides induce misreading in mammalian cells and assess endoplasmic reticulum (ER) stress and unfolded protein response (UPR) pathways. Genome-wide transcriptome and proteome analyses revealed upregulation of genes related to protein folding and degradation. Quantitative PCR confirmed induction of UPR markers including C/EBP homologous protein, glucose-regulated protein 94, binding immunoglobulin protein and X-box binding protein-1 (XBP1) mRNA splicing, which is crucial for UPR activation...
May 14, 2015: Cell Death & Disease
https://www.readbyqxmd.com/read/25841536/sudden-hearing-loss-and-crohn-disease-when-cogan-syndrome-must-be-suspected
#17
REVIEW
Giancarlo Tirelli, Paola Tomietto, Eliana Quatela, Fiorella Perrino, Luca Nicastro, Luigi Cattin, Renzo Carretta
Cogan's syndrome is a rare systemic vasculitis of unknown origin. It is characterized by the presence of worsening audiovestibular and ocular symptoms that may manifest simultaneously or sequentially. No specific diagnostic laboratory tests or imaging studies exist. The diagnosis is clinical and should be established as early as possible so as to initiate prompt treatment with steroids and prevent rapid progression to deafness or blindness and potentially fatal systemic involvement. We report a case of association between Cogan's syndrome and ileal Crohn's disease which we believe deserves attention since, after an accurate review of the literature, we have found approximately 250 reports of patients with Cogan's syndrome, only 13 of whom with concurrent chronic inflammatory bowel disease; of these 13 cases, none experienced improvement after therapy...
July 2015: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/25309440/application-of-insulin-like-growth-factor-1-in-the-treatment-of-inner-ear-disorders
#18
REVIEW
Norio Yamamoto, Takayuki Nakagawa, Juichi Ito
Sensorineural hearing loss (SNHL) is considered an intractable disease, given that hair and supporting cells (HCs and SCs) of the postnatal mammalian cochlea are unable to regenerate. However, with progress in regenerative medicine in the 21st century, several innovative approaches for achieving regeneration of inner ear HCs and SCs have become available. These methods include stem cell transplantation, overexpression of specific genes, and treatment with growth factors. Insulin-like growth factor-1 (IGF-1) is one of the growth factors that are involved in the development of the inner ear...
2014: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/24021919/inner-ear-insult-ablates-the-arousal-response-to-hypoxia-and-hypercarbia
#19
T Allen, A J Garcia Iii, J Tang, J M Ramirez, D D Rubens
INTRODUCTION: Sudden Infant Death Syndrome (SIDS) remains the leading cause of infant mortality in Western societies. A prior study identified an association between hearing suppression on the newborn hearing test and subsequent death from SIDS. This is the first finding of an abnormality in SIDS cases prior to death. A following study identified that inner ear dysfunction precipitates a marked suppression of the hypercapnic ventilatory response (HCVR). Failure of arousal has been proposed to be a key component in SIDS...
December 3, 2013: Neuroscience
https://www.readbyqxmd.com/read/23726954/habitual-use-of-push-and-pull-plastic-bottle-caps-is-more-prevalent-among-children-with-recurrent-acute-otitis-media
#20
Sara Torretta, Paola Marchisio, Maurizio Cappadona, Elena Baggi, Lorenzo Pignataro
OBJECTIVE: The use of a pacifier has been reported to be a causative factor of recurrent acute otitis media (RAOM) because the negative pressure which is generated during sucking may cause a negative intra-tympanic pressure and favour the reflux of nasopharyngeal secretions into the Eustachian tube. Push and pull (P&P) plastic bottle caps, recently marketed in Italy, might also induce negative nasopharyngeal pressure. This study was aimed to investigate if there is a difference in the prevalence of habitual use of P&P plastic bottle caps among children with a positive history of RAOM and healthy controls...
July 2013: International Journal of Pediatric Otorhinolaryngology
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