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https://www.readbyqxmd.com/read/28241470/pancreatic-exocrine-insufficiency-in-pancreatic-cancer
#1
REVIEW
Miroslav Vujasinovic, Roberto Valente, Marco Del Chiaro, Johan Permert, J-Matthias Löhr
Abstract: Cancer patients experience weight loss for a variety of reasons, commencing with the tumor's metabolism (Warburg effect) and proceeding via cachexia to loss of appetite. In pancreatic cancer, several other factors are involved, including a loss of appetite with a particular aversion to meat and the incapacity of the pancreatic gland to function normally when a tumor is present in the pancreatic head. Pancreatic exocrine insufficiency is characterized by a deficiency of the enzymes secreted from the pancreas due to the obstructive tumor, resulting in maldigestion...
February 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28238182/quantifying-trace-elements-in-the-emitted-particulate-matter-during-cooking-and-health-risk-assessment
#2
Soudabeh Gorjinezhad, Aiymgul Kerimray, Mehdi Amouei Torkmahalleh, Melek Keleş, Fatma Ozturk, Philip K Hopke
Particulate matter (PM) measurements were conducted during heating corn oil, heating corn oil mixed with the table salt and heating low fat ground beef meat using a PTFE-coated aluminum pan on an electric stove with low ventilation. The main objectives of this study were to measure the size segregated mass concentrations, emission rates, and fluxes of 24 trace elements emitted during heating cooking oil or oil with salt and cooking meat. Health risk assessments were performed based on the resulting exposure to trace elements from such cooking activities...
February 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28238104/microbial-carcinogenic-toxins-and-dietary-anti-cancer-protectants
#3
REVIEW
Trevor W Stone, L Gail Darlington
Several toxins are known which account for the ability of some bacteria to initiate or promote carcinogenesis. These ideas are summarised and evidence is discussed for more specific mechanisms involving chymotrypsin and the bacterial chymotryptic enzyme subtilisin. Subtilisin and Bacillus subtilis are present in the gut and environment and both are used commercially in agriculture, livestock rearing and meat processing. The enzymes deplete cells of tumour suppressors such as deleted in colorectal cancer (DCC) and neogenin, so their potential presence in the food chain might represent an important link between diet and cancer...
February 25, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28219238/public-health-risk-of-arsenic-species-in-chicken-tissues-from-live-poultry-markets-of-guangdong-province-china
#4
Yuanan Hu, Wenfeng Zhang, Hefa Cheng, Shu Tao
Arsenic-based feed additives, such as roxarsone (ROX), are still legally and widely used in food animal production in many countries. This study was conducted to systematically characterize the content and speciation of arsenic in chicken tissues from live poultry markets and in commercial chicken feeds in Guangdong, a major poultry production and consumption province in China, and to assess the corresponding public health risk. The total arsenic contents in the commercial feeds could be modeled as a mixture of two log-normal distributions (geometric means: 0...
February 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28217247/dietary-factors-can-protect-against-liver-cancer-development
#5
EDITORIAL
Lemonica Koumbi
Liver cancer is the third leading cause of cancer mortality worldwide with hepatocellular carcinoma (HCC) representing more than 90% of primary liver cancers. Most HCC patients are also suffering from chronic liver disease (CLD). Evidence is emerging that the composition of diet plays an important role in HCC and CLD development and may also have a chemoprotective role. In contrast to other types of cancer, there are few studies investigating the role of diet in hepatocarcinogenesis. From the available data it is evident that high intakes of red meat and dietary sugar positively correlate with HCC occurrence...
January 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28214186/characteristics-and-prognosis-of-japanese-colorectal-cancer-patients-the-biobank-japan-project
#6
Akiko Tamakoshi, Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Makoto Hirata, Akiko Nagai, Koichi Matsuda, Yoichiro Kamatani, Kaori Muto, Yutaka Kiyohara, Zentaro Yamagata, Toshiharu Ninomiya, Michiaki Kubo, Yusuke Nakamura
BACKGROUND: Colorectal cancer is the third most common cancer worldwide, and in Japan, it is estimated that about 10% of men and 8% of women will be diagnosed with colorectal cancer during their lifetime. METHODS: We focused on 5864 participants (3699 men and 2165 women) who had colorectal cancer and were registered with BioBank Japan (BBJ) between April 2003 and March 2008. Characteristics of colon and rectal cancer patients were calculated separately. Among the enrolled patients registered in BBJ within 90 days after diagnosis, we also calculated the 5-year cumulative and relative survival rates, and estimated the effect of lifestyle factors on all-cause mortality...
February 15, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28205448/association-between-red-meat-consumption-and-colon-cancer-a-systematic-review-of-experimental-results
#7
Nancy D Turner, Shannon K Lloyd
A role for red and processed meat in the development of colorectal cancer has been proposed based largely on evidence from observational studies in humans, especially in those populations consuming a westernized diet. Determination of causation specifically by red or processed meat is contingent upon identification of plausible mechanisms that lead to colorectal cancer. We conducted a systematic review of the available evidence to determine the availability of plausible mechanistic data linking red and processed meat consumption to colorectal cancer risk...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28195169/untargeted-metabolomics-of-colonic-digests-reveals-kynurenine-pathway-metabolites-dityrosine-and-3-dehydroxycarnitine-as-red-versus-white-meat-discriminating-metabolites
#8
Caroline Rombouts, Lieselot Y Hemeryck, Thomas Van Hecke, Stefaan De Smet, Winnok H De Vos, Lynn Vanhaecke
Epidemiological research has demonstrated that the consumption of red meat is an important risk factor for the development of colorectal cancer (CRC), diabetes mellitus and cardiovascular diseases. However, there is no holistic insight in the (by-) products of meat digestion that may contribute to disease development. To address this hiatus, an untargeted mass spectrometry (MS)-based metabolomics approach was used to create red versus white meat associated metabolic fingerprints following in vitro colonic digestion using the fecal inocula of ten healthy volunteers...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28191611/vegetarianism-and-colorectal-cancer-risk-in-a-low-selenium-environment-effect-modification-by-selenium-status-a-possible-factor-contributing-to-the-null-results-in-british-vegetarians
#9
REVIEW
Jakub G Sobiecki
BACKGROUND: Despite the consistent findings of lower total cancer incidence in vegetarians than in meat-eaters in the UK, the results of studies of colorectal cancer (CRC) risk in British vegetarians have largely been null. This was in contrast to the hypothesis of a decreased risk of CRC in this population due to null intake of red and processed meats and increased intake of fibre. Although the data are inconsistent, it has been suggested that selenium (Se) status may influence CRC risk...
February 13, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28187735/prognostic-value-of-alcohol-consumption-and-some-other-dietary-habits-for-survival-in-a-cohort-of-chinese-men-with-lung-cancer
#10
Wentao Li, Lap Ah Tse, Joseph S K Au, Kai Shing Yu, Feng Wang, Ignatius Tak-Sun Yu
BACKGROUND: Alcohol consumption and some other dietary habits are thought to be associated with lung cancer incidence. However, the effects of these habits on lung cancer prognosis have been studied rarely. The purpose of this study was to address these gaps in knowledge. METHODS: We studied a cohort of 1052 Chinese men in Hong Kong who were diagnosed with primary lung cancer. Cox proportional hazards models were used to determine the prognostic values of consumption of alcohol, fresh fruits or vegetables, meat, and fried or preserved food...
February 10, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28155006/adherence-to-the-mediterranean-diet-and-nasopharyngeal-cancer-risk-in-italy
#11
Federica Turati, Francesca Bravi, Jerry Polesel, Cristina Bosetti, Eva Negri, Werner Garavello, Martina Taborelli, Diego Serraino, Massimo Libra, Maurizio Montella, Adriano Decarli, Monica Ferraroni, Carlo La Vecchia
PURPOSE: Few studies investigated the role of diet on nasopharyngeal cancer (NPC) risk in non-endemic areas. The aim of this study was to assess the association between adherence to the traditional Mediterranean diet and NPC risk in a southern European low-risk population. METHODS: We conducted a hospital-based case-control study in Italy, including 198 histologically confirmed NPC cases and 594 matched controls. Dietary habits were collected by means of a validated food-frequency questionnaire, including 83 foods, food groups, or beverages...
February 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28153960/race-dependent-association-of-sulfidogenic-bacteria-with-colorectal-cancer
#12
Cemal Yazici, Patricia G Wolf, Hajwa Kim, Tzu-Wen L Cross, Karin Vermillion, Timothy Carroll, Gaius J Augustus, Ece Mutlu, Lisa Tussing-Humphreys, Carol Braunschweig, Rosa M Xicola, Barbara Jung, Xavier Llor, Nathan A Ellis, H Rex Gaskins
OBJECTIVE: Colorectal cancer (CRC) incidence is higher in African Americans (AAs) compared with non-Hispanic whites (NHWs). A diet high in animal protein and fat is an environmental risk factor for CRC development. The intestinal microbiota is postulated to modulate the effects of diet in promoting or preventing CRC. Hydrogen sulfide, produced by autochthonous sulfidogenic bacteria, triggers proinflammatory pathways and hyperproliferation, and is genotoxic. We hypothesised that sulfidogenic bacterial abundance in colonic mucosa may be an environmental CRC risk factor that distinguishes AA and NHW...
February 2, 2017: Gut
https://www.readbyqxmd.com/read/28139123/biomonitoring-dna-adducts-of-cooked-meat-carcinogens-in-human-prostate-by-nano-liquid-chromatography-high-resolution-tandem-mass-spectrometry-identification-of-2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine-dna-adduct
#13
Shun Xiao, Jingshu Guo, Byeong Hwa Yun, Peter W Villalta, Suprita Krishna, Resha Tejpaul, Paari Murugan, Christopher J Weight, Robert J Turesky
Epidemiologic studies have reported an association between frequent consumption of well-done cooked meats and prostate cancer risk. However, unambiguous physiochemical markers of DNA damage from carcinogens derived from cooked meats, such as DNA adducts, have not been identified in human samples to support this paradigm. We have developed a highly sensitive nano-LC-Orbitrap MS (n) method to measure DNA adducts of several carcinogens originating from well-done cooked meats, tobacco smoke, and environmental pollution, including 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-9H-pyrido[2,3-b]indole (AαC), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), benzo[a]pyrene (B[a]P), and 4-aminobiphenyl (4-ABP)...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28138038/early-suppression-of-adipocyte-lipid-turnover-induces-immunometabolic-modulation-in-cancer-cachexia-syndrome
#14
Felipe Santos Henriques, Rogério Antônio Laurato Sertié, Felipe Oliveira Franco, Pamela Knobl, Rodrigo Xavier Neves, Sandra Andreotti, Fabio Bessa Lima, Adilson Guilherme, Marilia Seelaender, Miguel Luiz Batista
Cancer cachexia is a multifactorial syndrome characterized by body weight loss, atrophy of adipose tissue (AT) and systemic inflammation. However, there is restrict information regarding the mechanisms of immunometabolic response in AT from cancer cachexia. Male Wistar rats were inoculated with 2 × 10(7) of Walker 256 tumor cells [tumor bearing (TB)]. The mesenteric AT (MeAT) was collected on d 0, 4, 7 (early stage), and 14 (cachexia stage) after tumor cell injection. Surgical biopsies for MeAT were obtained from patients who had gastrointestinal cancer with cachexia...
January 30, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28133481/a-case-control-study-of-risk-factors-for-salivary-gland-cancer-in-canada
#15
Sai Yi Pan, Margaret de Groh, Howard Morrison
Aim. To assess the effect of various lifestyle risk factors on the risk of salivary gland cancer in Canada using data from a population-based case-control study. Methods. Data from a population-based case-control study of 132 incident cases of salivary gland cancer and 3076 population controls were collected through self-administered questionnaire and analysed using unconditional logistic regression. Results. Four or more servings/week of processed meat product was associated with an adjusted odds ratio (OR) and corresponding 95% confidence interval (CI) of 1...
2017: Journal of Cancer Epidemiology
https://www.readbyqxmd.com/read/28125762/association-of-dietary-patterns-with-risk-of-colorectal-cancer-subtypes-classified-by-fusobacterium-nucleatum-in-tumor-tissue
#16
Raaj S Mehta, Reiko Nishihara, Yin Cao, Mingyang Song, Kosuke Mima, Zhi Rong Qian, Jonathan A Nowak, Keisuke Kosumi, Tsuyoshi Hamada, Yohei Masugi, Susan Bullman, David A Drew, Aleksandar D Kostic, Teresa T Fung, Wendy S Garrett, Curtis Huttenhower, Kana Wu, Jeffrey A Meyerhardt, Xuehong Zhang, Walter C Willett, Edward L Giovannucci, Charles S Fuchs, Andrew T Chan, Shuji Ogino
Importance: Fusobacterium nucleatum appears to play a role in colorectal carcinogenesis through suppression of the hosts' immune response to tumor. Evidence also suggests that diet influences intestinal F nucleatum. However, the role of F nucleatum in mediating the relationship between diet and the risk of colorectal cancer is unknown. Objective: To test the hypothesis that the associations of prudent diets (rich in whole grains and dietary fiber) and Western diets (rich in red and processed meat, refined grains, and desserts) with colorectal cancer risk may differ according to the presence of F nucleatum in tumor tissue...
January 26, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28122782/a-metabolomic-study-of-biomarkers-of-meat-and-fish-intake
#17
William Cheung, Pekka Keski-Rahkonen, Nada Assi, Pietro Ferrari, Heinz Freisling, Sabina Rinaldi, Nadia Slimani, Raul Zamora-Ros, Milena Rundle, Gary Frost, Helena Gibbons, Eibhlin Carr, Lorraine Brennan, Amanda J Cross, Valeria Pala, Salvatore Panico, Carlotta Sacerdote, Domenico Palli, Rosario Tumino, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Anna Floegel, Francesca Mancini, Marie-Christine Boutron-Ruault, Laura Baglietto, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Augustin Scalbert
BACKGROUND: Meat and fish intakes have been associated with various chronic diseases. The use of specific biomarkers may help to assess meat and fish intake and improve subject classification according to the amount and type of meat or fish consumed. OBJECTIVE: A metabolomic approach was applied to search for biomarkers of meat and fish intake in a dietary intervention study and in free-living subjects from the European Prospective Investigation into Cancer and Nutrition (EPIC) study...
January 25, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28120737/alberta-s-tomorrow-project-adherence-to-cancer-prevention-recommendations-pertaining-to-diet-physical-activity-and-body-size
#18
Heather K Whelan, Jian-Yi Xu, Sanaz Vaseghi, Geraldine Lo Siou, S Elizabeth McGregor, Paula J Robson
OBJECTIVE: To explore cross-sectional adherence to cancer prevention recommendations by adults enrolled in a prospective cohort in Alberta, Canada. DESIGN: Questionnaire data were used to construct a composite cancer prevention adherence score for each participant, based on selected personal recommendations published by the World Cancer Research Fund/American Institute for Cancer Research (2007). Data were self-reported on health and lifestyle, past-year physical activity and past-year FFQ...
January 25, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28109460/dietary-protein-sources-and-all-cause-and-cause-specific-mortality-the-golestan-cohort-study-in-iran
#19
Maryam S Farvid, Akbar F Malekshah, Akram Pourshams, Hossein Poustchi, Sadaf G Sepanlou, Maryam Sharafkhah, Masoud Khoshnia, Mojtaba Farvid, Christian C Abnet, Farin Kamangar, Sanford M Dawsey, Paul Brennan, Paul D Pharoah, Paolo Boffetta, Walter C Willett, Reza Malekzadeh
INTRODUCTION: Dietary protein comes from foods with greatly different compositions that may not relate equally with mortality risk. Few cohort studies from non-Western countries have examined the association between various dietary protein sources and cause-specific mortality. Therefore, the associations between dietary protein sources and all-cause, cardiovascular disease, and cancer mortality were evaluated in the Golestan Cohort Study in Iran. METHODS: Among 42,403 men and women who completed a dietary questionnaire at baseline, 3,291 deaths were documented during 11 years of follow up (2004-2015)...
February 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28094544/red-wine-and-pomegranate-extracts-suppress-cured-meat-promotion-of-colonic-mucin-depleted-foci-in-carcinogen-induced-rats
#20
Nadia M Bastide, Nathalie Naud, Gilles Nassy, Jean-Luc Vendeuvre, Sylviane Taché, Françoise Guéraud, Ditte A Hobbs, Gunter G Kuhnle, Denis E Corpet, Fabrice H F Pierre
Processed meat intake is carcinogenic to humans. We have shown that intake of a workshop-made cured meat with erythorbate promotes colon carcinogenesis in rats. We speculated that polyphenols could inhibit this effect by limitation of endogenous lipid peroxidation and nitrosation. Polyphenol-rich plant extracts were added to the workshop-made cured meat and given for 14 days to rats and 100 days to azoxymethane-induced rats to evaluate the inhibition of preneoplastic lesions. Colons of 100-d study were scored for precancerous lesions (mucin-depleted foci, MDF), and biochemical end points of peroxidation and nitrosation were measured in urinary and fecal samples...
February 2017: Nutrition and Cancer
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