keyword
https://read.qxmd.com/read/38131003/a-facile-strategy-for-the-fabrication-of-cell-laden-porous-alginate-hydrogels-based-on-two-phase-aqueous-emulsions
#21
JOURNAL ARTICLE
Wen Xue, Donghee Lee, Yunfan Kong, Mitchell Kuss, Ying Huang, Taesung Kim, Soonkyu Chung, Andrew T Dudley, Seung-Hyun Ro, Bin Duan
Porous alginate hydrogels possess many advantages as cell carriers. However, current pore generation methods require either complex or harsh fabrication processes, toxic components, or extra purification steps, limiting the feasibility and affecting the cellular survival and function. In this study, a simple and cell-friendly approach to generate highly porous cell-laden alginate hydrogels based on two-phase aqueous emulsions is reported. The pre-gel solutions, which contain two immiscible aqueous phases of alginate and caseinate, are crosslinked by calcium ions...
August 29, 2023: Advanced Functional Materials
https://read.qxmd.com/read/38116412/kinases-controlling-stability-of-the-oncogenic-mycn-protein
#22
JOURNAL ARTICLE
Nailah Smith, Eduard Reznik, Brygida Bisikirska, Vasiliki Polychronidou, Qian Wang, Arie Zask, Farhad Forouhar, Andrea Califano, Brent R Stockwell
We previously identified the natural products isopomiferin and pomiferin as powerful, indirect MYCN-ablating agents. In this work, we expand on their mechanism of action and find that casein kinase 2 (CK2), phosphoinositide 3-kinase (PI3K), checkpoint kinase 1 (CHK1) and serine/threonine protein kinase 38-like (STK38L), as well as STK38, work synchronously to create a field effect that maintains MYCN stability. By systematically inhibiting these kinases, we degraded MYCN and induced cell death. Additionally, we synthesized and tested several simpler and more cost-effective pomiferin analogues, which successfully emulated the compound's MYCN ablating activity...
December 14, 2023: ACS Medicinal Chemistry Letters
https://read.qxmd.com/read/38102186/tnf-%C3%AE-induced-down-regulation-of-type-i-interferon-receptor-contributes-to-acquired-resistance-of-cervical-squamous-cancer-to-cisplatin
#23
JOURNAL ARTICLE
Yani Yu, Jia Yu, Xiaorong Cui, Xin Sun, Xiaohui Yu
We aimed to investigate the effects of tumor necrosis factor (TNF)-α on the expression of interferon α/β receptor subunit 1 (IFNAR1) and cervical squamous cancer (CSCC) resistance to Cisplatin, as well as the underlying mechanisms. Kaplan-Meier analysis was used to plot the overall survival curves. SiHa cells were treated with 20 ng/ml TNF-α to determine cell proliferation in human CSCC cells and the expression of IFNAR1. The effects of TNF-α on the downstream signaling pathway, including casein kinase 1α (CK1α), were investigated using the caspase protease inhibitor FK009, the c-Jun kinase inhibitor SP600125, and the nuclear factor kappa-B inhibitor ammonium pyrrolidinedithiocarbamate (PDTC)...
December 15, 2023: Journal of Antibiotics
https://read.qxmd.com/read/38085607/design-and-development-of-ikzf2-and-ck1%C3%AE-dual-degraders
#24
JOURNAL ARTICLE
David K Miyamoto, Nicole M Curnutt, Sun-Mi Park, Alexios Stavropoulos, Michael G Kharas, Christina M Woo
Lenalidomide achieves its therapeutic efficacy by recruiting and removing proteins of therapeutic interest through the E3 ligase substrate adapter cereblon. Here, we report the design and characterization of 81 cereblon ligands for their ability to degrade the transcription factor Helios (IKZF2) and casein kinase 1 alpha (CK1α). We identified a key naphthamide scaffold that depleted both intended targets in acute myeloid leukemia MOLM-13 cells. Structure-activity relationship studies for degradation of the desired targets over other targets (IKZF1, GSPT1) afforded an initial lead compound DEG-35 ...
December 12, 2023: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38061356/subtype-selective-prenylated-isoflavonoids-disrupt-regulatory-drivers-of-mycn-amplified-cancers
#25
JOURNAL ARTICLE
Michael E Stokes, Alessandro Vasciaveo, Jonnell Candice Small, Arie Zask, Eduard Reznik, Nailah Smith, Qian Wang, Jacob Daniels, Farhad Forouhar, Presha Rajbhandari, Andrea Califano, Brent R Stockwell
Transcription factors have proven difficult to target with small molecules because they lack pockets necessary for potent binding. Disruption of protein expression can suppress targets and enable therapeutic intervention. To this end, we developed a drug discovery workflow that incorporates cell-line-selective screening and high-throughput expression profiling followed by regulatory network analysis to identify compounds that suppress regulatory drivers of disease. Applying this approach to neuroblastoma (NBL), we screened bioactive molecules in cell lines representing its MYC-dependent (MYCNA) and mesenchymal (MES) subtypes to identify selective compounds, followed by PLATESeq profiling of treated cells...
December 6, 2023: Cell Chemical Biology
https://read.qxmd.com/read/38023245/targeting-casein-kinase-1-for-cancer-therapy-current-strategies-and-future-perspectives
#26
REVIEW
Ngo Hoang Long, Sook-Jeong Lee
Casein Kinase 1 (CK1) is a family of serine/threonine protein kinases that play a crucial role in various cellular processes, including cell proliferation, survival, and metabolism. The dysregulation of CK1 expression has been implicated in the development and progression of several types of cancer, making it an attractive target for anticancer therapy. In this review, we provide an overview of the current strategies employed to target CK1 for cancer therapy and discuss the future perspectives in this field...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37977446/invited-review-camel-milk-and-gut-health-understanding-digestibility-and-the-impact-on-gut-microbiota
#27
REVIEW
Abdelmoneim H Ali, Siqi Li, Shao-Quan Liu, Ren-You Gan, Hua-Bin Li, Afaf Kamal-Eldin, Mutamed Ayyash
Camel milk (CM), known for its immune-regulatory, anti-inflammatory, antiapoptotic, and antidiabetic properties, is a natural healthy food. It is easily digestible due to the high levels of β-casein and diverse secreted antibodies, exhibiting superior antibacterial and antiviral activities compared with bovine milk. β-casein is less allergic and more digestible since it is more susceptible to the digestive hydrolysis in gut, and therefore, higher levels of β-casein make CM advantageous for human health...
November 15, 2023: Journal of Dairy Science
https://read.qxmd.com/read/37944834/ginsenoside-rh1-a-novel-casein-kinase-ii-subunit-alpha-ck2%C3%AE-inhibitor-retards-metastasis-via-disrupting-hhex-ccl20-signaling-cascade-involved-in-tumor-cell-extravasation-across-endothelial-barrier
#28
JOURNAL ARTICLE
Weiwei Zheng, Peiliang Shen, Chang Yu, Yu Tang, Cheng Qian, Chunmei Yang, Mingliang Gao, Yuanyuan Wu, Suyun Yu, Weiwei Tang, Guiping Wan, Aiyun Wang, Yin Lu, Yang Zhao
Tumor cell extravasation across endothelial barrier has been recognized as a pivotal event in orchestrating metastasis formation. This event is initiated by the interactions of extravasating tumor cells with endothelial cells (ECs). Therefore, targeting the crosstalk between tumor cells and ECs might be a promising therapeutic strategy to prevent metastasis. In this study, we demonstrated that Rh1, one of the main ingredients of ginseng, hindered the invasion of breast cancer (BC) cells as well as diminished the permeability of ECs both in vitro and in vivo, which was responsible for the attenuated tumor cell extravasation across endothelium...
November 7, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/37938186/csnk2-suppresses-autophagy-by-activating-fln-nhl-containing-trim-proteins
#29
JOURNAL ARTICLE
Helene Hoenigsperger, Lennart Koepke, Dhiraj Acharya, Victoria Hunszinger, Dennis Freisem, Alexander Grenzner, Sebastian Wiese, Frank Kirchhoff, Michaela U Gack, Konstantin M J Sparrer
Macroautophagy/autophagy is a tightly regulated cellular process integral to homeostasis and innate immunity. As such, dysregulation of autophagy is associated with cancer, neurodegenerative disorders, and infectious diseases. While numerous factors that promote autophagy have been characterized, the key mechanisms that prevent excessive autophagy are less well understood. Here, we identify CSNK2/CK2 (casein kinase 2) as a negative regulator of autophagy. Pharmacological inhibition of CSNK2 activity or siRNA-mediated depletion of CSNK2 increased basal autophagic flux in cell lines and primary human lung cells...
November 8, 2023: Autophagy
https://read.qxmd.com/read/37918594/fatty-acid-modification-of-casein-bioactive-peptides-nano-assemblies-synthesis-characterization-and-anticarcinogenic-effect
#30
JOURNAL ARTICLE
Yang Song, Zhichun Wang, Hang Ji, Zhongyou Jiang, Xiujuan Li, Zhongyao Du, Song Wei, Yang Sun
In this study, the nano-assemblies of bovine casein hydrolyzed peptides (HP) modified by fatty acids with various alkyl chain lengths (C8, C10, C12 and C14) were synthesized. The physicochemical properties of HP-C8 -HP-C14 nano-assemblies were characterized using spectra, laser particle size analyzer, contact angle meter, scanning electron microscope (SEM) and cryo-transmission electron microscope (Cryo-TEM). HP-C8 and HP-C10 self-assembled into a hollow cube cage with an average size of ~500 nm, and the assembly of HP-C12 showed a flower-shaped morphology with more dispersed behavior, and droplet size was observed as ~20 nm...
October 31, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37909596/use-of-nanoparticles-in-animal-models-for-prostate-cancer-treatment-a-systematic-review
#31
JOURNAL ARTICLE
Michele Selzler, Alexandre Moreira de Almeida, Marcelo Barbosa Neves, Alessandra de Figueiredo Gonçalves, Ricardo Dutra Aydos, Rondon Tosta Ramalho
PURPOSE: To conduct a systematic review of nanoparticles' use in the treatment of prostate cancer in animals. METHODS: A systematic review was conducted in the databases PubMed, Scientific Electronic Library Online (SciELO), Latin American and Caribbean Health Sciences Literature (LILACS), Cochrane Library, and EMBASE, and the descriptors were chosen based on terms indexed in Health Sciences Descriptors (DeCS)/Medical Subject Headings (MESH), which are: nanoparticles, nanomedicine, and prostate cancer...
2023: Acta Cirúrgica Brasileira
https://read.qxmd.com/read/37870169/inhibition-of-ck2-ing4-pathway-facilitates-non-small-cell-lung-cancer-immunotherapy
#32
JOURNAL ARTICLE
Qian Gou, Huiqing Chen, Mingjun Chen, Juanjuan Shi, Jianhua Jin, Qian Liu, Yongzhong Hou
Immune cells can protect against tumor progression by killing cancer cells, while aberrant expression of the immune checkpoint protein PD-L1 (programmed death ligand 1) in cancer cells facilitates tumor immune escape and inhibits anti-tumor immunotherapy. As a serine/threonine kinase, CK2 (casein kinase 2) regulates tumor progression by multiple pathways, while it is still unclear the effect of CK2 on tumor immune escape. Here it is found that ING4 induced PD-L1 autophagic degradation and inhibites non-small cell lung cancer (NSCLC) immune escape by increasing T cell activity...
October 23, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37846905/unlocking-the-potential-of-milk-whey-protein-components-in-colorectal-cancer-prevention-and-therapy
#33
REVIEW
Jianxin Xiao, Jiaying Ma, Muhammad Zahoor Khan, Gibson Maswayi Alugongo, Tianyu Chen, Shuai Liu, Shengli Li, Zhijun Cao
Extensive research from large prospective cohort studies and meta-analytical investigations over recent decades have consistently indicated that dairy foods have protective effects, reducing the risk of colorectal cancer. Most of the literature has explored the potential role of milk minerals and vitamins in managing colorectal cancer. Yet, there is a paucity of a comprehensive summary of the anticancer attributes of milk protein components and their underlying mechanisms of action. Recent advancements have spotlighted the potential of whey proteins, including β-lactoglobulin, α-lactalbumin, serum albumin, and lactoferrin, as promising candidates for both the prevention and treatment of colorectal cancer...
October 17, 2023: Critical Reviews in Food Science and Nutrition
https://read.qxmd.com/read/37803661/in-situ-extraction-encapsulation-of-olive-leaves-antioxidants-in-zein-for-improved-oxidative-stability-of-edible-oils
#34
JOURNAL ARTICLE
Amarilis Santos de Carvalho, Anielle de Oliveira, Thaysa Fernandes Moya Moreira, Luis Gustavo Médice Arabel Costa, Gabrielle Donato Marcatto, Andre da Silva Castilhos de Melo, Odinei Hess Gonçalves, Maria Inês Dias, Ricardo C Calhelha, Lillian Barros, Patricia Valderrama, Lucio Cardozo Filho, Fernanda Vitória Leimann
This study presents a sustainable and cost-effective method for preserving the bioactivity of phenolic compounds in olive leaves (OLE) during their application. The extraction and nanoencapsulation of OLE were performed in a single-step process using a rotor-stator system with zein as the encapsulating agent. The nanoprecipitation step was carried out using an aqueous sodium caseinate solution, resulting in spherical particles with an average diameter of about 640 nm, as confirmed by Transmission Electron Microscopy...
November 2023: Food Research International
https://read.qxmd.com/read/37779404/ck2b-is-a-prognostic-biomarker-and-a-potential-drug-target-for-hepatocellular-carcinoma
#35
JOURNAL ARTICLE
Huiru Dai, Minling Liu, Yuxi Pan, Tingwei Li, Yihang Pan, Zhesheng Chen, Jing Li, Yuchen Liu, Shuo Fang
BACKGROUND: Although casein kinase II subunit beta (CK2B) was previously reported to be involved in human cancers, such as hepatocellular carcinoma (HCC), there has been no systematic assessment of CK2B in HCC. OBJECTIVE: To assess the potential function of CK2B as a prognostic biomarker and possible druggable target in HCC. METHODS: The Cancer Genome Atlas database was accessed to investigate the potential oncogenic and prognostic roles of CK2B in HCC...
September 27, 2023: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/37759783/indomethacin-induces-spermidine-spermine-n-1-acetyltransferase-1-via-the-nucleolin-cdk1-axis-and-synergizes-with-the-polyamine-oxidase-inhibitor-methoctramine-in-lung-cancer-cells
#36
JOURNAL ARTICLE
Neudo Buelvas, Isidora Ugarte-Vio, Laura Asencio-Leal, Matías Muñoz-Uribe, Antonia Martin-Martin, Alejandro Rojas-Fernández, José A Jara, Julio C Tapia, María Elena Arias, Rodrigo A López-Muñoz
Indomethacin is a non-selective NSAID used against pain and inflammation. Although cyclooxygenase (COX) inhibition is considered indomethacin's primary action mechanism, COX-independent ways are associated with beneficial effects in cancer. In colon cancer cells, the activation of the peroxisome proliferator-activated receptor-γ (PPAR-γ) is related to the increase in spermidine/spermine-N1 -acetyltransferase-1 (SSAT-1), a key enzyme for polyamine degradation, and related to cell cycle arrest. Indomethacin increases the SSAT-1 levels in lung cancer cells; however, the mechanism relying on the SSAT-1 increase is unclear...
September 12, 2023: Biomolecules
https://read.qxmd.com/read/37738679/high-throughput-screening-of-the-saccharomyces-cerevisiae-genome-for-2-amino-3-methylimidazo-4-5-f-quinoline-resistance-identifies-colon-cancer-associated-genes
#37
JOURNAL ARTICLE
Michael Dolan, Nick St John, Faizan Zaidi, Francis Doyle, Michael Fasullo
Heterocyclic aromatic amines (HAAs) are potent carcinogenic agents found in charred meats and cigarette smoke. However, few eukaryotic resistance genes have been identified. We used Saccharomyces cerevisiae (budding yeast) to identify genes that confer resistance to 2-amino-3-methylimidazo[4,5-f] quinoline (IQ). CYP1A2 and NAT2 activate IQ to become a mutagenic nitrenium compound. Deletion libraries expressing human CYP1A2 and NAT2 or no human genes were exposed to either 400 or 800 µM IQ for five or ten generations...
September 22, 2023: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/37736507/bamlet-bovine-%C3%AE-lactalbumin-made-lethal-to-tumor-cells-inhibits-autophagy-flux-and-induces-apoptosis-via-down-regulation-of-protein-kinase-ck1%C3%AE-and-attenuation-of-the-akt-p-%C3%A3-catenin-s552-pathway-in-ras-mutated-human-colorectal-hct-116-cells
#38
JOURNAL ARTICLE
Hamid Behrouj, Pooneh Mokarram
OBJECTIVES: Oncogenic RAS mutations occur in nearly 50% of colorectal cancer cases and are usually dependent on the autophagy mechanism to maintain tumorigenesis. We have recently demonstrated that CK1α controls autophagy machinery possibly through the AKT/p-ß-catenin (S552) signaling in colorectal cancer cells harboring RAS mutation. It has been found that a lipid-protein complex comprising oleic acid binds to human α-lactalbumin, known as HAMLET (human α -lactalbumin made lethal to tumor cells), targets a broad range of kinases including CK1α...
2023: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/37721093/axin-phosphorylation-in-condensates-counteracts-tankyrase-mediated-degradation
#39
JOURNAL ARTICLE
Katharina Klement, Martina Brückner, Dominic B Bernkopf
Axin is a central negative regulator of the proto-oncogenic Wnt/β-catenin signaling pathway, as axin condensates provide a scaffold for the assembly of a multiprotein complex degrading β-catenin. Axin in turn is degraded via tankyrase. Consequently, small molecule tankyrase inhibitors block Wnt signaling by stabilizing axin, revealing potential for cancer therapy. Here, we discover phosphorylation of axin by casein kinase 1α (CK1α) at an N-terminal CK1 consensus motif, which was antagonized by protein phosphatase 1 (PP1)...
September 18, 2023: Journal of Cell Science
https://read.qxmd.com/read/37702657/ck1%C3%AE-and-ck1%C3%AE%C2%B5-signaling-sustains-mitochondrial-metabolism-and-cell-survival-in-multiple-myeloma
#40
JOURNAL ARTICLE
Karen L Burger, Mario R Fernandez, Mark B Meads, Praneeth Sudalagunta, Paula S Oliveira, Rafael Renatino Canevarolo, Raghunandan Reddy Alugubelli, Alexandre Tungsevik, Gabe De Avila, Maria Silva, Allison I Graeter, Hongyue A Dai, Nicole D Vincelette, Antony Prabhu, Dario Magaletti, Chunying Yang, Weimin Li, Amit Kulkarni, Oliver Hampton, John M Koomen, William R Roush, Andrii Monastyrskyi, Anders E Berglund, Ariosto S Silva, John L Cleveland, Kenneth H Shain
UNLABELLED: Multiple myeloma remains an incurable malignancy due to acquisition of intrinsic programs that drive therapy resistance. Here we report that casein kinase-1δ (CK1δ) and CK1ε are therapeutic targets in multiple myeloma that are necessary to sustain mitochondrial metabolism. Specifically, the dual CK1δ/CK1ε inhibitor SR-3029 had potent in vivo and ex vivo anti-multiple myeloma activity, including against primary multiple myeloma patient specimens...
December 1, 2023: Cancer Research
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