keyword
https://read.qxmd.com/read/37900240/effect-of-polyene-phosphatidylcholine-ursodeoxycholic-acid-ademetionine-on-pregnancy-outcomes-in-intrahepatic-cholestasis
#21
JOURNAL ARTICLE
Xiao-Rui Dong, Qian-Qian Chen, Meng-Ling Xue, Ling Wang, Qin Wu, Teng-Fei Luo
BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder that occurs in pregnant women and can lead to a range of adverse pregnancy outcomes. The condition is typically marked by pruritus (itching) and elevated levels of liver enzymes and bile acids. The standard treatment for ICP has generally been ursodeoxycholic acid and ademetionine 1,4-butanedisulfonate, but the efficacy of this approach remains less than optimal. Recently, polyene phosphatidylcholine has emerged as a promising new therapeutic agent for ICP due to its potential hepatoprotective effects...
September 26, 2023: World Journal of Clinical Cases
https://read.qxmd.com/read/37892703/bile-acids-pneumonia-a-respiratory-distress-syndrome-in-early-term-neonates
#22
JOURNAL ARTICLE
Alessandro Perri, Maria Letizia Patti, Margherita Velardi, Annamaria Sbordone, Giorgia Prontera, Simona Fattore, Vito D'Andrea, Milena Tana, Giovanni Vento
Intrahepatic cholestasis of pregnancy (ICP) complicates among 0.2-2% of pregnancies and has been associated with adverse perinatal outcomes, including sudden stillbirth, meconium strained fluid, preterm birth, perinatal asphyxia, and transient tachypnea of the newborn. The diagnosis of "bile acids pneumonia" was previously proposed and a causative role of bile acids (BA) was supposed with a possible mechanism of action including surfactant dysfunction, inflammation, and chemical pneumonia. In the last few years, the role of lung ultrasound (LUS) in the diagnosis and management of neonatal respiratory distress syndrome has grown, and LUS scores have been introduced in the literature, as an effective predictor of the need for surfactant treatment among neonates with respiratory distress syndrome...
October 17, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37851654/maternal-and-neonatal-outcomes-in-patients-with-hepatitis-c-and-intrahepatic-cholestasis-of-pregnancy-the-sum-of-the-parts
#23
JOURNAL ARTICLE
Emily C Goins, Lauren E Wein, Virginia Y Watkins, Alexa I K Campbell, R Phillips Heine, Brenna L Hughes, Sarah K Dotters-Katz, Jerome Jeffrey Federspiel
OBJECTIVE: Hepatitis C virus and intrahepatic cholestasis of pregnancy (ICP) are well-known independent risk factors for adverse outcomes in pregnancy. In addition, it is well-established that there is an association between Hepatitis C and ICP. This study's objective was to describe the impact of having both Hepatitis C and ICP on maternal and obstetric outcomes compared to patients having either Hepatitis C or ICP. METHODS: We conducted a retrospective cohort study of the Nationwide Readmissions Database, an all-payor sample of discharges from approximately 60% of US hospitalizations...
2023: PloS One
https://read.qxmd.com/read/37798517/obeticholic-acid-alleviates-intrauterine-growth-restriction-induced-by-di-ethyl-hexyl-phthalate-in-pregnant-female-mice-by-improving-bile-acid-disorder
#24
JOURNAL ARTICLE
Fan Zhao, Lun Zhang, Mingchao Qu, Lu Ye, Jiayi Zhang, Yun Yu, Qianqian Huang, Cheng Zhang, Jianqing Wang
Di-(2-ethylhexyl)-phthalate (DEHP) is a ubiquitous environmental pollutant and is widely used in industrial plastics. Intrahepatic cholestasis of pregnancy (ICP), distinguished by maternal pruritus and elevated serum bile acid levels, is linked to unfavorable pregnancy consequences. Few studies have investigated the potential effect of gestational DEHP exposure on the cholestasis in pregnant female mice, and the underlying mechanisms remain unclear. In the present study, a mouse model of cholestasis during pregnancy was established by DEHP exposure...
October 6, 2023: Environmental Science and Pollution Research International
https://read.qxmd.com/read/37755306/effects-of-pregnancy-on-plasma-sphingolipids-using-a-metabolomic-and-quantitative-analysis-approach
#25
JOURNAL ARTICLE
Luke F Enthoven, Yuanyuan Shi, Emily Fay, Agnes Kim, Sue Moreni, Jennie Mao, Nina Isoherranen, Rheem A Totah, Mary F Hebert
Changes in the maternal metabolome, and specifically the maternal lipidome, that occur during pregnancy are relatively unknown. The objective of this investigation was to evaluate the effects of pregnancy on sphingolipid levels using metabolomics analysis followed by confirmational, targeted quantitative analysis. We focused on three subclasses of sphingolipids: ceramides, sphingomyelins, and sphingosines. Forty-seven pregnant women aged 18 to 50 years old participated in this study. Blood samples were collected on two study days for metabolomics analysis...
September 21, 2023: Metabolites
https://read.qxmd.com/read/37744532/expression-and-significance-of-galectin-1-and-galectin-3-in-the-serum-and-placental-tissues-of-patients-with-intrahepatic-cholestasis-of-pregnancy
#26
JOURNAL ARTICLE
Li-Hua Qian, Xiang Kong, Liu-Lin Zhou
BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, usually occurring in the third trimester of pregnancy. Its typical clinical manifestations are itching and elevated serum total bile acid levels, which are more harmful to the fetus, and can lead to a variety of adverse pregnancy outcomes. This paper discusses the expressions of galectin -1 and 3 in the serum and placenta of ICP patients and their relationship with the effect of the incidence of ICP...
August 2023: Iranian Journal of Public Health
https://read.qxmd.com/read/37743645/associations-between-aldob-polymorphisms-and-intrahepatic-cholestasis-of-pregnancy-susceptibility-in-the-chinese-han-population
#27
JOURNAL ARTICLE
Xianxian Liu, Siming Xin, Jiusheng Zheng, Huai Liu, Yang Zeng, Xiaoying Wu, Feng Zhang, Xiaoming Zeng, Yang Zou, Hua Lai
OBJECTIVES: To research the associations between fructose-bisphosphate aldolase B (ALDOB) gene polymorphisms and intrahepatic cholestasis of pregnancy (ICP) risk. MATERIAL AND METHODS: Whole-genome sequencing (WGS) was performed to detect ALDOB polymorphisms. Five web-available tools were employed to predict the effect of the site variant on the protein. Protein structure comparisons between the reference and ALDOB-modified samples were performed by SWISS-MODEL and Chimera 1...
September 25, 2023: Ginekologia Polska
https://read.qxmd.com/read/37719856/hepatoprotective-agents-in-the-management-of-intrahepatic-cholestasis-of-pregnancy-current-knowledge-and-prospects
#28
REVIEW
Dan Shan, Siyu Dai, Qian Chen, Yupei Xie, Yayi Hu
Intrahepatic cholestasis of pregnancy (ICP) is characterized by unexplained distressing pruritus in the mother and poses significant risk to the fetus of perinatal mortality. Occurring in the second and third trimester, the serum bile acid and aminotransferase are usually elevated in ICP patients. Ursodeoxycholic acid (UDCA) is the first line drug for ICP but the effectiveness for hepatoprotection is to a certain extent. In ICP patients with severe liver damage, combination use of hepatoprotective agents with UDCA is not uncommon...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37679010/azathioprine-and-6-mercaptopurine-induced-intrahepatic-cholestasis-of-pregnancy-case-report-and-review-of-the-literature
#29
Maya Frank Wolf, Ronen Sloma, Luiza Akria, Eli Rimon, Yifat Wiener, Michal Carmiel Haggai, Lior Lowenstein
OBJECTIVE: Azathioprine, a prodrug of 6-mercaptopurine (6-MP), is used in the treatment of inflammatory bowel disease and may be continued during pregnancy. Acute cholestatic liver injury has been reported to occur with azathioprine. We aimed to examine azathioprine related cholestasis effect on pregnancy complications and outcome. CASE REPORT: We present a unique case of 6-MP-induced severe intrahepatic cholestasis of pregnancy (ICP) that required meticulous combined therapy including plasma exchange...
September 2023: Taiwanese Journal of Obstetrics & Gynecology
https://read.qxmd.com/read/37650679/a-comprehensive-review-of-novel-biomarkers-in-the-diagnosis-of-intrahepatic-cholestasis-of-pregnancy
#30
REVIEW
Weici Liu, Lingyan Chen, Wenxiang Wang, Zhiran Yue, Jingyang Li, Mengjing Tan, Ying Gu, Ru Zhu, Yan Zhang
Intrahepatic cholestasis of pregnancy (ICP) is a disease specific to pregnancy, featuring maternal itching and elevated serum bile acid levels. It leads to a series of adverse pregnancy outcomes as well as increased fetal mortality. Routine biochemical markers fail to fulfill the tremendous clinical requirements, thereby novel effective biomarkers are urgently desired. In our review, the potential novel biomarkers for ICP diagnosis are classified into four categories and elaborated in detail. The concrete diagnostic performances (sensitivity, specificity and area under the curve) of these biomarkers are demonstrated in tables...
August 31, 2023: Biomarkers in Medicine
https://read.qxmd.com/read/37546542/revisited-role-of-the-placenta-in-bile-acid-homeostasis
#31
REVIEW
Edgar Ontsouka, Mariana Schroeder, Christiane Albrecht
To date, the discussion concerning bile acids (BAs) during gestation is almost exclusively linked to pregnancy complications such as intrahepatic cholestasis of pregnancy (ICP) when maternal serum BA levels reach very high concentrations (>100 μM). Generally, the placenta is believed to serve as a protective barrier avoiding exposure of the growing fetus to excessive amounts of maternal BAs that might cause detrimental effects (e.g., intrauterine growth restriction and/or increased vulnerability to metabolic diseases)...
2023: Frontiers in Physiology
https://read.qxmd.com/read/37470272/risk-stratified-management-strategies-for-intrahepatic-cholestasis-of-pregnancy-a-tertiary-center-population-review-over-nearly-5%C3%A2-years
#32
JOURNAL ARTICLE
Tingting Xu, Yongchi Zhan, Daijuan Chen, Xixi Deng, Chihui Mao, Jinfeng Xu, Xing Wang, Bing Guo, Xiaodong Wang
OBJECTIVE: Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of adverse perinatal outcomes, resulting in a higher risk of perinatal morbidity and mortality. METHODS: The authors conducted a retrospective study of 2385 singletons with ICP who underwent risk-stratified management strategies. To explore the risks of perinatal outcomes of ICP, subgroup analyses were performed using different total bile acid (TBA) levels. RESULTS: In this study, there was only one stillbirth and one neonatal death...
July 20, 2023: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/37422150/sex-dependent-differences-in-cholestasis-why-estrogen-signaling-may-be-a-key-pathophysiological-driver
#33
REVIEW
AbdiGhani Ismail, Lindsey Kennedy, Heather Francis
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are cholestatic liver diseases that have significant clinical impact with debilitating symptoms and mortality. PBC is predominantly seen in perimenopausal and postmenopausal women; men who are diagnosed with PBC have worse clinical outcomes and all-cause mortality. In contrast, 60% to 70% of patients with PSC are men; the data indicate that female sex may be an independent factor against PSC-related complications. These findings suggest a sex-dependent biological basis for these differences...
July 6, 2023: American Journal of Pathology
https://read.qxmd.com/read/37417244/antenatal-thiopurine-exposure-in-women-with-ibd-is-associated-with-intrahepatic-cholestasis-of-pregnancy
#34
JOURNAL ARTICLE
Christian P Selinger, Konstantina Rosiou, Giacomo Broglio, Gillian Lever, Chun Ming Chiu, Linden J Stocker, Hlupekile Chipeta, Tracey Glanville
BACKGROUND: Pregnant women with Inflammatory Bowel Disease (IBD) continue thiopurines to maintain remission. Other studies have reported intrahepatic cholestasis of pregnancy (ICP) in IBD pregnancies exposed to thiopurines. We aimed to investigate whether thiopurines are associated with an increased risk of ICP. RESEARCH DESIGN AND METHODS: Single-center retrospective cohort study comparing incidence of ICP in thiopurine exposed versus non-exposed patients with IBD compared with age matched pregnant controls...
July 7, 2023: Expert Opinion on Drug Safety
https://read.qxmd.com/read/37293299/effects-of-hbsag-carriers-on-pregnancy-complications-in-pregnant-women-a-retrospective-cohort-study
#35
JOURNAL ARTICLE
Mengqing Weng, Jie Wang, Jingfeng Yin, Wenning Ren, Caiping Wei, Wenshan Yang, Huimin He
OBJECTIVE: Hepatitis B virus (HBV) infection is a major health threat worldwide, especially in developing countries. We aimed to investigate the impact of hepatitis B carrier on pregnancy complications in pregnant women, in China. METHODS: This retrospective cohort study was conducted by using data from the EHR system of Longhua District People's Hospital in Shenzhen, China, from January 2018 to June 2022. Binary logistic regression was used to evaluate the relationship between HBsAg carrier status and pregnancy complications and pregnancy outcomes...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37268909/platelet-counts-affect-the-association-between-hyperhomocysteinemia-and-pregnancy-complications
#36
JOURNAL ARTICLE
Bin Yu, Bin Zhang, Xiaoya Han, Wei Long, Wenbo Zhou, Xiaosong Yuan
BACKGROUND: The joint effect of platelet and other modifiers on the risk of pregnancy complications is unknown. This study investigated whether platelet count (PC) and total homocysteine (tHcy) level have a synergistic effect on the incidence of pregnancy complications in a Chinese population. METHODS: Total 11,553 consecutive pregnant women who received whole blood cell and biochemical tests at the time of admission for labor in Changzhou Maternal and Child Health Care Hospital were analyzed...
June 2, 2023: BMC Public Health
https://read.qxmd.com/read/37223869/treatment-of-hepatitis-e
#37
JOURNAL ARTICLE
Wei Hui, Linlin Wei
Hepatitis E virus (HEV) infections are the most common cause of acute hepatitis, but they can also take a chronic course. There is no specific therapy for acute hepatitis, and current treatment is supportive. Choosing ribavirin as the first-line therapy for chronic HEV is advisable, especially immunosuppressed individuals. Moreover, ribavirin therapy in the acute phase of infection provides major benefits for those at high risk of acute liver failure (ALF)/acute-on-chronic liver failure (ACLF). Pegylated interferon α has been used successfully for treatment of hepatitis E but is associated with major side effects...
2023: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/37215870/intrahepatic-cholestasis-of-pregnancy-worsening-perinatal-depressive-tendency-a-follow-up-study-from-the-second-trimester-to-the-sixth-week-postpartum
#38
JOURNAL ARTICLE
Xu Hualin, Xu Yupin, Zhao Guoqiang, Fu Xukun, Lin Hongmei
The total bile acid (TBA) is usually used to diagnose intrahepatic cholestasis of pregnancy (ICP) as a common clinical index. Recently many research reports on the microbiota-gut-brain axis (MGB axis) suggest that bile acids have an influence on human mental illnesses such as anxiety and depression, linked closely to intestinal microbial population. However, there is still a lack of clinical data to support intrinsic relationships about human cases. In this study, we conducted a follow-up study of 25 ICP and 98 healthy pregnant women to investigate the influence of ICP disease on perinatal depression...
May 2023: Heliyon
https://read.qxmd.com/read/37212775/mdr3-rs2109505-and-rs1202283-polymorphisms-are-associated-with-susceptibility-to-intrahepatic-cholestasis-of-pregnancy-a-meta-analysis
#39
JOURNAL ARTICLE
Haiyan Zhuo, Jinhai Fan, Lvfeng Yao, Liqing Zheng, Yihong Chai
BACKGROUND: Many studies have assessed the relationship between gene polymorphisms in multidrug resistance protein 3 (MDR3) and the risk of intrahepatic cholestasis of pregnancy (ICP); however, there are many conflicting narratives. OBJECTIVES: This meta-analysis was conducted to assess the association between MDR3 gene polymorphisms and ICP. MATERIAL AND METHODS: A multi-database search was conducted using Web of Science, Embase, PubMed, and Chinese Biomedical Literature (CBM) databases...
May 22, 2023: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/37158870/interactive-effects-of-gestational-diabetes-mellitus-and-maximum-level-of-total-bile-acid-in-maternal-serum-on-adverse-pregnancy-outcomes-in-women-with-intrahepatic-cholestasis-of-pregnancy
#40
JOURNAL ARTICLE
Tingting Liao, Xia Xu, Yulong Zhang, Jianying Yan
OBJECTIVE: To study the combined effect of gestational diabetes mellitus (GDM) and maximum level of maternal serum total bile acid (TBA) on the incidence of adverse pregnancy outcomes in women with intrahepatic cholestasis of pregnancy (ICP). METHODS: This was an observational study with 724 women with ICP. Perinatal outcomes were compared by the presence of GDM. Logistic regression was used to assess the independent and multiplicative interactions of GDM and maximum maternal serum TBA on adverse pregnancy outcomes...
May 8, 2023: BMC Pregnancy and Childbirth
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