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https://www.readbyqxmd.com/read/28300790/non-destructive-detection-of-wire-rope-discontinuities-from-residual-magnetic-field-images-using-the-hilbert-huang-transform-and-compressed-sensing
#1
Juwei Zhang, Xiaojiang Tan, Pengbo Zheng
Electromagnetic methods are commonly employed to detect wire rope discontinuities. However, determining the residual strength of wire rope based on the quantitative recognition of discontinuities remains problematic. We have designed a prototype device based on the residual magnetic field (RMF) of ferromagnetic materials, which overcomes the disadvantages associated with in-service inspections, such as large volume, inconvenient operation, low precision, and poor portability by providing a relatively small and lightweight device with improved detection precision...
March 16, 2017: Sensors
https://www.readbyqxmd.com/read/28221827/hormonally-mediated-increases-in-sex-biased-gene-expression-accompany-the-breakdown-of-between-sex-genetic-correlations-in-a-sexually-dimorphic-lizard
#2
Robert M Cox, Christian L Cox, Joel W McGlothlin, Daren C Card, Audra L Andrew, Todd A Castoe
The evolution of sexual dimorphism is predicted to occur through reductions in between-sex genetic correlations (rmf) for shared traits, but the physiological and genetic mechanisms that facilitate these reductions remain largely speculative. Here, we use a paternal half-sibling breeding design in captive brown anole lizards (Anolis sagrei) to show that the development of sexual size dimorphism is mirrored by the ontogenetic breakdown of rmf for body size and growth rate. Using transcriptome data from the liver (which integrates growth and metabolism), we show that sex-biased gene expression also increases dramatically between ontogenetic stages bracketing this breakdown of rmf...
March 2017: American Naturalist
https://www.readbyqxmd.com/read/28094917/tuning-the-ignition-performance-of-a-microchip-initiator-by-integrating-various-al-moo3-reactive-multilayer-films-on-a-semiconductor-bridge
#3
Jianbing Xu, Yu Tai, Chengbo Ru, Ji Dai, Yinghua Ye, Ruiqi Shen, Peng Zhu
Reactive multilayer films (RMFs) can be integrated into semiconducting electronic structures with the use of microelectromechanical systems (MEMS) technology and represent potential applications in the advancement of microscale energy-demanding systems. In this study, aluminum/molybdenum trioxide (Al/MoO3)-based RMFs with different modulation periods were integrated on a semiconductor bridge (SCB) using a combination of an image reversal lift-off process and magnetron sputtering technology. This produced an energetic semiconductor bridge (ESCB)-chip initiator with controlled ignition performance...
January 31, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28074534/depolarizing-gaba-contributes-to-glutamatergic-network-rewiring-in-epilepsy
#4
Nazim Kourdougli, Christophe Pellegrino, Juho-Matti Renko, Stanislav Khirug, Geneviève Chazal, Tiina-Kaisa Kukko-Lukjanov, Sari E Lauri, Jean-Luc Gaiarsa, Liang Zhou, Angélique Peret, Eero Castrén, Raimo Kalevi Tuominen, Valérie Crépel, Claudio Rivera
OBJECTIVE: Rewiring of excitatory glutamatergic neuronal circuits is a major abnormality in epilepsy. Besides the rewiring of excitatory circuit, an abnormal depolarizing GABAergic drive has been hypothesized to participate in the epileptogenic processes. However, a remaining clinically relevant question is whether early post Status Epilepticus (SE) evoked chloride dysregulation is important for the remodeling of aberrant glutamatergic neuronal circuit. METHODS: Osmotic mini-pumps were used to infuse intracerebrally a specific inhibitor of depolarizing GABAergic transmission as well as a functionally blocking antibody towards the pan-neurotrophin receptor p75 (p75(NTR) )...
January 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28047372/su-f-t-128-dose-volume-constraints-for-particle-therapy-treatment-planning
#5
R Stewart, W Smith, K Hendrickson, J Meyer, N Cao, E Lee, O Gopan, G Sandison, U Parvathaneni, G Laramore
PURPOSE: Determine equivalent Organ at Risk (OAR) tolerance dose (TD) constraints for MV x-rays and particle therapy. METHODS: Equivalent TD estimates for MV x-rays are determined from an isoeffect, regression-analysis of published and in-house constraints for various fractionation schedules (n fractions). The analysis yields an estimate of (α/β) for an OAR. To determine equivalent particle therapy constraints, the MV x-ray TD(n) values are divided by the RBE for DSB induction (RBEDSB ) or cell survival (RBES )...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27939605/dynamics-of-the-escherichia-coli-proteome-in-response-to-nitrogen-starvation-and-entry-into-the-stationary-phase
#6
Heloisa B S Sanchuki, Fernanda Gravina, Thiago E Rodrigues, Edileusa C M Gerhardt, Fábio O Pedrosa, Emanuel M Souza, Roberto T Raittz, Glaucio Valdameri, Gustavo A de Souza, Luciano F Huergo
Nitrogen is needed for the biosynthesis of biomolecules including proteins and nucleic acids. In the absence of fixed nitrogen prokaryotes such as E. coli immediately ceases growth. Ammonium is the preferred nitrogen source for E. coli supporting the fastest growth rates. Under conditions of ammonium limitation, E. coli can use alternative nitrogen sources to supply ammonium ions and this reprogramming is led by the induction of the NtrC regulon. Here we used label free proteomics to determine the dynamics of E...
March 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27863925/number-and-function-of-circulating-endothelial-progenitor-cells-in-patients-with-primary-budd-chiari-syndrome
#7
Rui Huang, Qingqiao Zhang, Qianxin Huang, Maoheng Zu, Hao Xu, Lingyu Zeng
BACKGROUND AND AIM: Primary Budd-Chiari syndrome (BCS) is associated with vascular endothelial injury. Circulating endothelial progenitor cells (EPCs) provide an endogenous mechanism to repair endothelial injury. This study investigated the levels and functionality of EPCs in patients with primary BCS. METHODS: EPCs (CD34(+)/CD133(+)/KDR(+)) were quantified in 82 patients with primary BCS (inferior vena cava type: n=19; hepatic vein type: n=22; and mixed type: n=41), 10 cirrhosis controls (CC group) and 10 age-matched healthy controls (HC group), using flow cytometry...
November 15, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27786558/increased-water-content-in-bacterial-cellulose-synthesized-under-rotating-magnetic-fields
#8
Karol Fijałkowski, Anna Żywicka, Radosław Drozd, Adam Feliks Junka, Dorota Peitler, Marian Kordas, Maciej Konopacki, Patrycja Szymczyk, Rafał Rakoczy
The current study describes properties of bacterial cellulose (BC) obtained from Komagataeibacter xylinus cultures exposed to the rotating magnetic field (RMF) of 50 Hz frequency and magnetic induction of 34 mT for controlled time during 6 days of cultivation. The experiments were carried out in the customized RMF exposure system adapted for biological studies. The obtained BC displayed an altered micro-structure, degree of porosity, and water-related parameters in comparison to the non-treated, control BC samples...
2017: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/27779404/rotation-driven-microfluidic-disc-for-white-blood-cell-enumeration-using-magnetic-bead-aggregation
#9
Yiwen Ouyang, Jingyi Li, Doris M Haverstick, James P Landers
We recently defined a magnetic bead-based assay that exploited an agglutination-like response for DNA and applied it to DNA-containing cell enumeration using inexpensive benchtop hardware [ J. Am. Chem. Soc. 2012 , 134 ( 12 ), 5689 - 96 ]. Although cost-efficient, the open-well format assay required numerous manual steps, and the magnetic field actuation scheme was not readily adaptable for integration. Here, we demonstrate a low-cost (<$2 in-lab), higher-throughput "pinwheel assay" platform that relies on a combination of a disposable rotation-driven microdisc (RDM), and a simple bidirectional rotating magnetic field (bi-RMF)...
November 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27681765/evaluation-of-functional-marrow-irradiation-based-on-skeletal-marrow-composition-obtained-using-dual-energy-computed-tomography
#10
Taiki Magome, Jerry Froelich, Yutaka Takahashi, Luke Arentsen, Shernan Holtan, Michael R Verneris, Keenan Brown, Akihiro Haga, Keiichi Nakagawa, Jennifer L Holter Chakrabarty, Sebastian Giebel, Jeffrey Wong, Kathryn Dusenbery, Guy Storme, Susanta K Hui
PURPOSE: To develop an imaging method to characterize and map marrow composition in the entire skeletal system, and to simulate differential targeted marrow irradiation based on marrow composition. METHODS AND MATERIALS: Whole-body dual energy computed tomography (DECT) images of cadavers and leukemia patients were acquired, segmented to separate bone marrow components, namely, bone, red marrow (RM), and yellow marrow (YM). DECT-derived marrow fat fraction was validated using histology of lumbar vertebrae obtained from cadavers...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27577585/eleven-year-descriptive-analysis-of-closed-court-verdicts-on-medical-errors-in-spain-and-massachusetts
#11
Priscila Giraldo, Luke Sato, Jose M Martínez-Sánchez, Mercè Comas, Kathy Dwyer, Maria Sala, Xavier Castells
OBJECTIVES: To evaluate and compare the characteristics of court verdicts on medical errors allegedly harming patients in Spain and Massachusetts from 2002 to 2012. DESIGN, SETTING AND PARTICIPANTS: We reviewed 1041 closed court verdicts obtained from data on litigation in the Thomson Reuters Aranzadi Westlaw databases in Spain (Europe), and 370 closed court verdicts obtained from the Controlled Risk and Risk Management Foundation of Harvard Medical Institutions (CRICO/RMF) in Massachusetts (USA)...
2016: BMJ Open
https://www.readbyqxmd.com/read/27574849/rosae-multiflorae-fructus-hot-water-extract-inhibits-a-murine-allergic-asthma-via-the-suppression-of-th2-cytokine-production-and-histamine-release-from-mast-cells
#12
Chang Ho Song, Thi Tho Bui, Chun Hua Piao, Hee Soon Shin, Dong-Hwa Shon, Eui-Hyeog Han, Hyoung Tae Kim, Ok Hee Chai
Mast cell-mediated anaphylactic reactions are involved in many allergic diseases, including asthma and allergic rhinitis. In Korea, where it has been used as a traditional medicine, Rosae Multiflorae fructus (RMF) is known to have potent antioxidative, analgesic, and anti-inflammatory activities and to have no obvious acute toxicity. However, its specific effect on asthma is still unknown. In this study, we evaluated whether or not RMF hot water extracts (RMFW) could inhibit ovalbumin (OVA)-induced allergic asthma and evaluated compound 48/80-induced mast cell activation to elucidate the mechanisms of asthma inhibition by RMFW...
September 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27203864/biologically-optimized-helium-ion-plans-calculation-approach-and-its-in-vitro-validation
#13
A Mairani, I Dokic, G Magro, T Tessonnier, F Kamp, D J Carlson, M Ciocca, F Cerutti, P R Sala, A Ferrari, T T Böhlen, O Jäkel, K Parodi, J Debus, A Abdollahi, T Haberer
Treatment planning studies on the biological effect of raster-scanned helium ion beams should be performed, together with their experimental verification, before their clinical application at the Heidelberg Ion Beam Therapy Center (HIT). For this purpose, we introduce a novel calculation approach based on integrating data-driven biological models in our Monte Carlo treatment planning (MCTP) tool. Dealing with a mixed radiation field, the biological effect of the primary (4)He ion beams, of the secondary (3)He and (4)He (Z  =  2) fragments and of the produced protons, deuterons and tritons (Z  =  1) has to be taken into account...
June 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27007305/salt-effects-on-functional-traits-in-model-and-in-economically-important-lotus-species
#14
COMPARATIVE STUDY
P Uchiya, F J Escaray, D Bilenca, F Pieckenstain, O A Ruiz, A B Menéndez
A common stress on plants is NaCl-derived soil salinity. Genus Lotus comprises model and economically important species, which have been studied regarding physiological responses to salinity. Leaf area ratio (LAR), root length ratio (RLR) and their components, specific leaf area (SLA) and leaf mass fraction (LMF) and specific root length (SRL) and root mass fraction (RMF) might be affected by high soil salinity. We characterised L. tenuis, L. corniculatus, L. filicaulis, L. creticus, L. burtii and L. japonicus grown under different salt concentrations (0, 50, 100 and 150 mm NaCl) on the basis of SLA, LMF, SRL and RMF using PCA...
July 2016: Plant Biology
https://www.readbyqxmd.com/read/26765506/seedling-root-responses-to-soil-moisture-and-the-identification-of-a-belowground-trait-spectrum-across-three-growth-forms
#15
Julie E Larson, Jennifer L Funk
Root trait variation and plasticity could be key factors differentiating plant performance under drought. However, water manipulation and root measurements are rarely coupled empirically across growth forms to identify whether belowground strategies are generalizable across species. We measured seedling root traits across three moisture levels in 18 Mediterranean forbs, grasses, and woody species. Drought increased the root mass fraction (RMF) and decreased the relative proportion of thin roots (indicated by increased root diameters and decreased specific root length (SRL)), rates of root elongation and growth, plant nitrogen uptake, and plant growth...
May 2016: New Phytologist
https://www.readbyqxmd.com/read/26752481/clinical-outcome-following-radiofrequency-denervation-for-refractory-sacroiliac-joint-dysfunction-using-the-simplicity-iii-probe-a-12-month-retrospective-evaluation
#16
Dominic Hegarty
BACKGROUND: Sacroiliac joint syndrome (SIJ) is diagnosed in 10% to 25% of cases of lower back pain. The response to traditional radiofrequency (RF) denervation of the SIJ has being inconsistent. The Simplicity III RF probe (Neruotherm. Inc.) offers a novel treatment option. OBJECTIVE: To evaluate the long-term clinical outcome (12 months) refractory SIJ syndrome in terms of pain intensity and functional improvement. A 50% reduction in intensity pain intensity (VAS) at 12 months was deemed clinically significant...
January 2016: Pain Physician
https://www.readbyqxmd.com/read/26688548/structure-of-a-tcr-mimic-antibody-with-target-predicts-pharmacogenetics
#17
Niloufar Ataie, Jingyi Xiang, Neal Cheng, Elliott J Brea, Wenjie Lu, David A Scheinberg, Cheng Liu, Ho Leung Ng
Antibody therapies currently target only extracellular antigens. A strategy to recognize intracellular antigens is to target peptides presented by immune HLA receptors. ESK1 is a human, T-cell receptor (TCR)-mimic antibody that binds with subnanomolar affinity to the RMF peptide from the intracellular Wilms tumor oncoprotein WT1 in complex with HLA-A*02:01. ESK1 is therapeutically effective in mouse models of WT1(+) human cancers. TCR-based therapies have been presumed to be restricted to one HLA subtype. The mechanism for the specificity and high affinity of ESK1 is unknown...
January 16, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/26460998/fast-biological-modeling-for-voxel-based-heavy-ion-treatment-planning-using-the-mechanistic-repair-misrepair-fixation-model-and-nuclear-fragment-spectra
#18
COMPARATIVE STUDY
Florian Kamp, Gonzalo Cabal, Andrea Mairani, Katia Parodi, Jan J Wilkens, David J Carlson
PURPOSE: The physical and biological differences between heavy ions and photons have not been fully exploited and could improve treatment outcomes. In carbon ion therapy, treatment planning must account for physical properties, such as the absorbed dose and nuclear fragmentation, and for differences in the relative biological effectiveness (RBE) of ions compared with photons. We combined the mechanistic repair-misrepair-fixation (RMF) model with Monte Carlo-generated fragmentation spectra for biological optimization of carbon ion treatment plans...
November 1, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26443727/modification-of-the-ribosome-and-the-translational-machinery-during-reduced-growth-due-to-environmental-stress
#19
Antón Vila-Sanjurjo
Escherichia coli strains normally used under laboratory conditions have been selected for maximum growth rates and require maximum translation efficiency. Recent studies have shed light on the structural and functional changes undergone by the translational machinery in E. coli during heat and cold shock and upon entry into stationary phase. In these situations both the composition and the partitioning of this machinery into the different pools of cellular ribosomes are modified. As a result, the translational capacity of the cell is dramatically altered...
September 2008: EcoSal Plus
https://www.readbyqxmd.com/read/26433486/high-resource-capture-and-use-efficiency-and-effective-antioxidant-protection-contribute-to-the-invasiveness-of-alnus-formosana-plants
#20
Shiliang Liu, Yiming Luo, Rongjie Yang, Chengxiang He, Qingsu Cheng, Jianjun Tao, Bo Ren, Maohua Wang, Mingdong Ma
To investigate the traits contributing to the invasiveness of Alnus formosana and the mechanisms underlying its invasiveness, we compared A. formosana with its native congener (Alnus cremastogyne) under three light treatments (13%, 56%, and 100%). The consistently higher plant height, total leaf area, light-saturated photosynthetic rate (A(max)), light saturation point (LSP), light compensation point (LCP), respiration efficiency (RE), and non-photochemical quenching coefficient (NPQ) but lower root mass fraction (RMF) and specific leaf area (SLA) of the invader than of its native congener contributed to the higher RGR and total biomass of A...
November 2015: Plant Physiology and Biochemistry: PPB
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