keyword
https://read.qxmd.com/read/38525967/application-of-platysma-myocutaneous-flap-in-surgical-repair-after-t2-3-glottic-carcinoma-resection
#1
JOURNAL ARTICLE
Wenying Zhu, Haifeng Liang, Faya Liang, Renhui Chen, Shibei Zheng, Wenting Liang, Zhong Guan, Qian Cai
OBJECTIVE: Numerous methods and materials are available for vertical partial laryngectomy. In this study, the reparative effects of the platysma myocutaneous flap (PMF) and ribbon myocutaneous flap (RMF) on the postoperative voice quality of patients were compared to provide a reference for selecting a method conducive to improving postoperative voice quality. METHODS: A retrospective analysis was performed on patients with unilateral T2-3 glottic carcinoma. Following vertical partial laryngectomy, the defect was repaired with a PMF or simple RMF...
March 25, 2024: Laryngoscope
https://read.qxmd.com/read/38465244/effects-of-polyamines-and-indole-on-the-expression-of-ribosome-hibernation-factors-in-escherichia-coli-at-the-translational-level
#2
JOURNAL ARTICLE
E A Khaova, A G Tkachenko
Polyamines and indole are small regulatory molecules that are involved in the adaptation to stress in bacteria, including the regulation of gene expression. Genes, the translation of which is under the regulatory effects of polyamines, form the polyamine modulon. Previously, we showed that polyamines upregulated the transcription of genes encoding the ribosome hibernation factors RMF, RaiA, SRA, EttA and RsfS in Escherichia coli. At the same time, indole affected the expression at the transcriptional level of only the raiA and rmf genes...
February 2024: Vavilovskii Zhurnal Genetiki i Selektsii
https://read.qxmd.com/read/38420580/gradient-rotating-magnetic-fields-impairing-f-actin-related-gene-ccdc150-to-inhibit-triple-negative-breast-cancer-metastasis-by-inactivating-tgf-%C3%AE-1-smad3-signaling-pathway
#3
JOURNAL ARTICLE
Ge Zhang, Tongyao Yu, Xiaoxia Chai, Shilong Zhang, Jie Liu, Yan Zhou, Dachuan Yin, Chenyan Zhang
Triple-negative breast cancer (TNBC) is the most aggressive and lethal malignancy in women, with a lack of effective targeted drugs and treatment techniques. Gradient rotating magnetic field (RMF) is a new technology used in oncology physiotherapy, showing promising clinical applications due to its satisfactory biosafety and the abundant mechanical force stimuli it provides. However, its antitumor effects and underlying molecular mechanisms are not yet clear. We designed two sets of gradient RMF devices for cell culture and animal handling...
2024: Research: a science partner journal
https://read.qxmd.com/read/38327684/variations-in-root-architecture-traits-and-their-association-with-organ-mass-fraction-of-common-annual-ephemeral-species-in-the-desert-of-northern-xinjiang
#4
JOURNAL ARTICLE
Taotao Wang, Bangyan Liu, Xuan Zhang, Mao Wang, Dunyan Tan
The variation of plant traits is closely related to the trade-offs between resource acquisition and conservation, as well as the accumulation of biomass. However, there has been a lack of comprehensive insights into the variation patterns, phylogenetic conservatism, and covariation with biomass allocation of root system architecture in desert areas. We examined the root systems of 47 annual ephemeral species and evaluated their biomass allocation and six key root system architecture traits. Our results indicated that the variation in root traits mainly originated from interspecific variation (48...
February 2024: Ecology and Evolution
https://read.qxmd.com/read/38316316/wound-recovery-efficacy-of-retinol-based-micellar-formulations-in-an-organotypic-skin-wound-model
#5
JOURNAL ARTICLE
David O Oluwole, Josue Diaz-Delgado, Will Buchanan, Roberto M La Ragione, Tao Chen, Lian X Liu
Impairment of the skin's structural integrity initially results in acute wounds which can become chronic if timely wound closure is not achieved. Chronic wounds (CWs) affect more than 1% of the global population with increasing cases of this condition due to the ageing population. Current wound management relies on debridement, hyperbaric oxygen, antibiotics, and wound dressings, which lack early intervention and specificity. Herein, antibiotics-free retinol-based micellar formulations (RMF) were made and their wound healing efficacy were investigated in vitro...
February 3, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38308338/multifunctional-conductive-and-electrogenic-hydrogel-repaired-spinal-cord-injury-via-immunoregulation-and-enhancement-of-neuronal-differentiation
#6
JOURNAL ARTICLE
Mingshan Liu, Wencan Zhang, Shuwei Han, Dapeng Zhang, Xiaolong Zhou, Xianzheng Guo, Haosheng Chen, Haifeng Wang, Lin Jin, Shiqing Feng, Zhijian Wei
Spinal cord injury (SCI) is a refractory neurological disorder. Due to the complex pathological processes, especially the secondary inflammatory cascade and the lack of intrinsic regenerative capacity, it is difficult to recover neurological function after SCI. Meanwhile, simulating the conductive microenvironment of the spinal cord promises to reconstruct electrical neural signal transmission interrupted by SCI and facilitates the neural repair. A double-crosslinked conductive hydrogel (BP@Hydrogel) containing black phosphorus nanoplates (BP) is synthesized...
February 2, 2024: Advanced Materials
https://read.qxmd.com/read/38304921/acquisition-of-educational-values-at-the-real-madrid-foundation-s-social-sports-schools
#7
JOURNAL ARTICLE
Gema Ortega-Vila, Enrique Ortega-Toro, Francisco Javier Giménez-Fuentes-Guerra, José Robles-Rodríguez, Francisco Alarcón-López, Manuel Tomás Abad-Robles
The objective of this study was to analyse the impact of the educational programme of the Real Madrid Foundation (RMF) on the acquisition of educational values at social-sports football and basketball schools among children aged between 12 and 16 years in Italy, Romania, Spain and the United Kingdom. The most significant results showed that: (a) between the 20-21 and 21-22 seasons, there were statistically significant increases in personal and team success, self-fulfilment, personal and group superiority, health and physical fitness, and peaceful behaviour; and (b) the increase in variables being studied was different according to the country analysed in such a way that: in the per-sonal and team success dimension there was a rise in the United Kingdom and Italy; in self-fulfilment there was an increase in the United Kingdom; in the personal and group superiority dimension there was a rise in Italy and Romania; in the health and physical fitness dimension there was an increase in social-sports schools in the United Kingdom and Italy; in the peaceful behaviour dimension there was a rise in social-sports schools in the United Kingdom and a drop in social-sports schools in Romania...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38297477/rosae-multiflorae-fructus-regulates-the-lipogenesis-in-high-fat-diet-induced-nafld-mice-model
#8
JOURNAL ARTICLE
Kibong Kim, Hyun Joo Jang, Suji Baek, Sang-Hyun Ahn
PURPOSE: Exercise helps modify the lipid profile in the body, partly through its impact on sterol regulatory element binding protein-1 (SREBP-1) and peroxisome proliferator-activated receptor-γ (PPAR-γ). Individual differences in response to exercise and genetic variations may influence the response to PA. Therefore, this study explored Rosae multiflorae fructus (RMF) as a supplement candidate that improves exercise capacity and controls non-alcoholic fatty liver disease (NAFLD) by suppressing lipogenesis and controlling lipid peroxidation...
December 2023: Physical activity and nutrition
https://read.qxmd.com/read/38275988/postoperative-nausea-and-vomiting-following-endoscopic-sinus-surgery-under-the-guidance-of-adequacy-of-anesthesia-or-pupillometry-with-intravenous-propofol-remifentanil
#9
JOURNAL ARTICLE
Michał J Stasiowski, Nikola Zmarzły, Beniamin Oskar Grabarek, Jakub Gąsiorek
Postoperative nausea and vomiting (PONV) constitutes an adverse event after endoscopic sinus surgery (ESS) under general anesthesia (GA) with intravenous opioids, such as remifentanil (RMF). Monitoring the nociception/antinociception balance using the surgical pleth index (SPI) or pupillary dilatation reflex (PRD) helps guide intravenous RMF infusion. We aimed to investigate whether their employment could help reduce the incidence of PONV in patients undergoing ESS. The data of 30 patients from the GA group, 31 from the SPI group, and 28 from the PRD group were analyzed...
December 19, 2023: Pharmaceuticals
https://read.qxmd.com/read/38256006/the-influence-of-graphene-oxide-fe-3-o-4-differently-conjugated-with-10-hydroxycampthotecin-and-a-rotating-magnetic-field-on-adenocarcinoma-cells
#10
JOURNAL ARTICLE
Magdalena Jedrzejczak-Silicka, Karolina Szymańska, Ewa Mijowska, Rafał Rakoczy
Nanoparticles (e.g., graphene oxide, graphene oxide-Fe3 O4 nanocomposite or hexagonal boron nitride) loaded with anti-cancer drugs and targeted at cancerous cells allowed researchers to determine the most effective in vitro conditions for anticancer treatment. For this reason, the main propose of the present study was to determine the effect of graphene oxide (GO) with iron oxide (Fe3 O4 ) nanoparticles (GO-Fe3 O4 ) covalently (c-GO-Fe3 O4 -HCPT) and non-covalently (nc-GO-Fe3 O4 -HCPT) conjugated with hydroxycamptothecin (HCPT) in the presence of a rotating magnetic field (RMF) on relative cell viability using the MCF-7 breast cancer cell line...
January 11, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38205800/urchin-like-fe-3-o-4-bi-2-s-3-nanospheres-enable-the-destruction-of-biofilm-and-efficiently-antibacterial-activities
#11
JOURNAL ARTICLE
Yaqian Xu, Benjin Chen, Lingling Xu, Guoqiang Zhang, Limian Cao, Nian Liu, Wanni Wang, Haisheng Qian, Min Shao
Biofilm-associated infections (BAIs) have been considered a major threat to public health, which induce persistent infections and serious complications. The poor penetration of antibacterial agents in biofilm significantly limits the efficiency of combating BAIs. Magnetic urchin-like core-shell nanospheres of Fe3 O4 @Bi2 S3 were developed for physically destructing biofilm and inducing bacterial eradication via reactive oxygen species (ROS) generation and innate immunity regulation. The urchin-like magnetic nanospheres with sharp edges of Fe3 O4 @Bi2 S3 exhibited propeller-like rotation to physically destroy biofilm under a rotating magnetic field (RMF)...
January 11, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38182308/estimate-of-the-random-match-frequency-of-acquired-characteristics-in-footwear-part-ii-impressions-in-dust
#12
JOURNAL ARTICLE
Alyssa N Smale, Jacqueline A Speir
This study serves as Part II of an investigation into the random match frequency of randomly acquired characteristics (RAC-RMF) in footwear evidence. In Part I, RAC-RMF was estimated in a dataset of laboratory-simulated crime scene impressions deposited in blood. For Part II, a second dataset was created composed of impressions deposited in dust on paper or tile, with the latter lifted using gelatin or Mylar film. A total of 1,513 RACs were identified from more than 160 dust impressions and compared to RACs with positional similarity in test impressions from 1,299 non-mated outsoles...
January 2024: Science & Justice: Journal of the Forensic Science Society
https://read.qxmd.com/read/38182307/estimate-of-the-random-match-frequency-of-acquired-characteristics-in-footwear-part-i-impressions-in-blood
#13
JOURNAL ARTICLE
Alyssa N Smale, Jacqueline A Speir
The aim of this study was to estimate random match frequency of randomly acquired characteristics (RAC-RMF) for laboratory-simulated crime scene impressions. Part I of this investigation reports this metric using a dataset of more than 160 questioned impressions created in blood and deposited on tile. A total of 759 RACs were identified in the blood impressions and compared to RACs with positional similarity in test impressions from 1,299 unrelated outsoles. Geometric similarity was quantified using a combination of visual comparisons and mathematical modeling based on percent area overlap...
January 2024: Science & Justice: Journal of the Forensic Science Society
https://read.qxmd.com/read/38065297/sedation-with-propofol-remifentanil-versus-dexmedetomidine-remifentanil-for-patients-undergoing-transcatheter-aortic-valve-implant-a-retrospective-study-between-2012-and-2019
#14
JOURNAL ARTICLE
B H Vela, P J Cubillo, C B Fernández, L G Ligorit, M C Ferrer Gracía, J Antonio Diarte
BACKGROUND AND OBJECTIVES: Percutaneous implantation of an aortic valve prosthesis is a therapeutic alternative for patients with severe aortic stenosis. The procedure is traditionally performed under general anaesthesia; however, sedation is now gaining in popularity because it reduces the need for vasoactive drugs and shortens the patient's stay in the critical care unit and on the ward. The aim of this study is to evaluate the clinical efficacy, safety and potential benefits of sedation with dexmedetomidine in patients undergoing percutaneous implantation of an aortic valve prosthesis in terms of haemodynamic and respiratory complications...
December 6, 2023: Revista española de anestesiología y reanimación
https://read.qxmd.com/read/38048594/dual-receptor-t-cell-platform-with-ab-tcr-and-costimulatory-receptor-achieves-specificity-and-potency-against-aml
#15
JOURNAL ARTICLE
Tao Dao, Guangyan Xiong, Sung Soo Mun, Jeremy Meyerberg, Tatyana Korontsvit, Jingyi Xiang, Ziyou Cui, Aaron Y Chang, Casey A Jarvis, Winson Cai, Hanzhi Luo, Aspen J Pierson, Anthony F Daniyan, Sarah Yoo, Sumiko Takao, Michael Gregory Kharas, Alex Kentsis, Cheng Liu, David A Scheinberg
Chimeric antigen receptor T cell (CAR T) therapy has produced remarkable clinical responses in B cell neoplasms. However, many challenges limit this class of agents for the treatment of other cancer types, in particular the lack of tumor-selective antigens for solid tumors and other hematological malignancies, such as Acute Myeloid Leukemia (AML), that may be addressed without significant risk of severe toxicities while providing sufficient abundance for efficient tumor suppression. One approach to overcome this hurdle is dual targeting by an antibody-T cell receptor (AbTCR) and a chimeric costimulatory signaling receptor (CSR) to two different antigens, in which both antigens are found together on the cancer cells, but not together on normal cells...
December 4, 2023: Blood
https://read.qxmd.com/read/37991821/recommendations-on-scuba-diving-in-birt-hogg-dub%C3%A3-syndrome
#16
REVIEW
L van Riel, R A van Hulst, L van Hest, Rja van Moorselaar, B G Boerrigter, S M Franken, Rmf Wolthuis, H J Dubbink, S J Marciniak, N Gupta, I van de Beek, A C Houweling
INTRODUCTION: Although very uncommon, severe injury and death can occur during scuba diving. One of the main causes of scuba diving fatalities is pulmonary barotrauma due to significant changes in ambient pressure. Pathology of the lung parenchyma, such as cystic lesions, might increase the risk of pulmonary barotrauma. AREAS COVERED: Birt-Hogg-Dubé syndrome (BHD), caused by pathogenic variants in the FLCN gene, is characterized by skin fibrofolliculomas, an increased risk of renal cell carcinoma, multiple lung cysts and spontaneous pneumothorax...
November 22, 2023: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/37947135/size-dependent-magnetomechanically-enhanced-photothermal-antibacterial-effect-of-fe-3-o-4-au-pda-nanodurian
#17
JOURNAL ARTICLE
Yunqi Xu, Kang Wang, Yi Zhu, Jing Wang, Dazheng Ci, Min Sang, Qunling Fang, Huaxia Deng, Xinglong Gong, Ken Cham-Fai Leung, Shouhu Xuan
The global health crisis of bacterial resistance to antibiotics requires innovative antibacterial strategies. One promising solution is the exploitation of multifunctional nanoplatforms based on non-resistant antibacterial mechanisms. This work reports a novel Fe3 O4 @Au/polydopamine (PDA) nanodurian with excellent photothermal-magnetomechanic synergistic antibacterial effects. The one-step formed Au/PDA hybrid shell provides good photothermal properties and spiky surfaces for enhanced magnetomechanic effects...
November 10, 2023: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/37943032/csra-coordinates-the-expression-of-ribosome-hibernation-and-anti-%C3%AF-factor-proteins
#18
JOURNAL ARTICLE
Christine Pourciau, Helen Yakhnin, Archanna Pannuri, Mark G Gorelik, Ying-Jung Lai, Tony Romeo, Paul Babitzke
Bacterial growth rate varies due to changing physiological signals and is fundamentally dependent on protein synthesis. Consequently, cells alter their transcription and translation machinery to optimize the capacity for protein production under varying conditions and growth rates. Our findings demonstrate that the post-transcriptional regulator CsrA in Escherichia coli controls the expression of genes that participate in these processes. During exponential growth, CsrA represses the expression of proteins that alter or inhibit RNA polymerase (RNAP) and ribosome activity, including the ribosome hibernation factors RMF, RaiA, YqjD, ElaB, YgaM, and SRA, as well as the anti-σ70 factor, Rsd...
November 9, 2023: MBio
https://read.qxmd.com/read/37749761/react-reframe-and-engage-establishing-a-receiver-mindset-for-more-effective-safety-negotiations
#19
JOURNAL ARTICLE
Melanie Barlow, Bernadette Watson, Kate Morse, Elizabeth Jones, Fiona Maccallum
PURPOSE: The response of the receiver to a voiced patient safety concern is frequently cited as a barrier to health professionals speaking up. The authors describe a novel Receiver Mindset Framework (RMF) to help health professionals understand the importance of their response when spoken up to. DESIGN/METHODOLOGY/APPROACH: The framework draws on the broader receiver-focussed literature and integrates innovative findings from a series of empirical studies. These studies examined different receiver behaviour within vignettes, retrospective descriptions of real interactions and behaviour in a simulated interaction...
September 26, 2023: Journal of Health Organization and Management
https://read.qxmd.com/read/37746329/inductive-sensing-of-magnetic-microrobots-under-actuation-by-rotating-magnetic-fields
#20
JOURNAL ARTICLE
Michael G Christiansen, Lucien R Stöcklin, Cameron Forbrigger, Shashaank Abhinav Venkatesh, Simone Schuerle
The engineering space for magnetically manipulated biomedical microrobots is rapidly expanding. This includes synthetic, bioinspired, and biohybrid designs, some of which may eventually assume clinical roles aiding drug delivery or performing other therapeutic functions. Actuating these microrobots with rotating magnetic fields (RMFs) and the magnetic torques they exert offers the advantages of efficient mechanical energy transfer and scalable instrumentation. Nevertheless, closed-loop control still requires a complementary noninvasive imaging modality to reveal position and trajectory, such as ultrasound or X-rays, increasing complexity and posing a barrier to use...
September 2023: PNAS Nexus
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