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pathophysiology cholestasis of pregnancy

https://read.qxmd.com/read/38513931/metabolomic-profiling-of-serum-and-tongue-coating-of-pregnant-women-with-intrahepatic-cholestasis-in-pregnancy
#1
JOURNAL ARTICLE
Feng Zhang, Fang Liu, Xiaoyi Xu, Weilan Su, Yu Rong, Fu-Ying Tian, Weimin Xiao, Yichun Wu, Kai P Law, Ping Wen
Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of cesarean section and adverse fetal outcomes. Currently, ICP diagnosis depends largely on serum levels of bile acids and lacks sensitivity and specificity for accurate diagnosis. Tongue diagnosis is an important diagnostic tool in traditional Chinese medicine (TCM) and is used in our clinic as complementary treatment and personalized medicine for ICP. However, the molecular basis of the manifestation of greasy white tongue coatings in ICP remains unknown...
March 19, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38469760/role-of-systemic-immune-inflammatory-index-to-predict-intrahepatic-cholestasis-of-pregnancy
#2
JOURNAL ARTICLE
Seval Y Ergani, Sevki Celen
BACKGROUND: The goal was to investigate the change of systemic immune inflammation index (SII) in high-risk pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP). METHODS: Between May 2018 and April 2020, we retrospectively enrolled 218 pregnant women who were followed in our hospital from the first trimester to delivery. We looked at the sociodemographics, laboratory data, SII values, Apgar ratings, and newborn birth weights of pregnant women with ICP...
March 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38177949/proteomic-biomarkers-of-intrahepatic-cholestasis-of-pregnancy
#3
JOURNAL ARTICLE
Weijian Zeng, Yanyan Hou, Wei Gu, Zheng Chen
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, which can lead to adverse fetal outcomes, including preterm labor and intrauterine death. The pathogenesis of ICP is still unclear. We hypothesized that pathological index leads to abnormal placenta changes in ICP. Investigation of these differences in protein expression in parallel profiling is essential to understand the comprehensive pathophysiological mechanism underlying ICP. The present study screened differentially expressed proteins (DEPs) as novel diagnostic markers for ICP...
January 4, 2024: Reproductive Sciences
https://read.qxmd.com/read/37763154/diagnostic-approach-to-elevated-liver-function-tests-during-pregnancy-a-pragmatic-narrative-review
#4
JOURNAL ARTICLE
Elton Dajti, Angelo Bruni, Giovanni Barbara, Francesco Azzaroli
Liver disease is not uncommon during pregnancy and is associated with increased maternal and fetal/neonatal morbidity and mortality. Physiological changes during pregnancy, including a hyperestrogenic state, increase in circulating plasma volume and/or reduction in splanchnic vascular resistance, and hemostatic imbalance, may mimic or worsen liver disease. For the clinician, it is important to distinguish among the first presentation or exacerbation of chronic liver disease, acute liver disease non-specific to pregnancy, and pregnancy-specific liver disease...
September 16, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37744532/expression-and-significance-of-galectin-1-and-galectin-3-in-the-serum-and-placental-tissues-of-patients-with-intrahepatic-cholestasis-of-pregnancy
#5
JOURNAL ARTICLE
Li-Hua Qian, Xiang Kong, Liu-Lin Zhou
BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, usually occurring in the third trimester of pregnancy. Its typical clinical manifestations are itching and elevated serum total bile acid levels, which are more harmful to the fetus, and can lead to a variety of adverse pregnancy outcomes. This paper discusses the expressions of galectin -1 and 3 in the serum and placenta of ICP patients and their relationship with the effect of the incidence of ICP...
August 2023: Iranian Journal of Public Health
https://read.qxmd.com/read/37422150/sex-dependent-differences-in-cholestasis-why-estrogen-signaling-may-be-a-key-pathophysiological-driver
#6
REVIEW
AbdiGhani Ismail, Lindsey Kennedy, Heather Francis
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are cholestatic liver diseases that have significant clinical impact with debilitating symptoms and mortality. PBC is predominantly seen in perimenopausal and postmenopausal women; men who are diagnosed with PBC have worse clinical outcomes and all-cause mortality. In contrast, 60% to 70% of patients with PSC are men; the data indicate that female sex may be an independent factor against PSC-related complications. These findings suggest a sex-dependent biological basis for these differences...
July 6, 2023: American Journal of Pathology
https://read.qxmd.com/read/37185229/the-spatial-expression-of-mtorc2-akt-ip3r-signal-pathway-in-mitochondrial-combination-of-endoplasmic-reticulum-of-maternal-fetal-interface-trophoblast-in-intrahepatic-cholestasis-of-pregnancy
#7
JOURNAL ARTICLE
Yaqian Li, Daijuan Chen, Jinfeng Xu, Xiaodong Wang, Fan Zhou
OBJECTIVES: Intrahepatic cholestasis of pregnancy (ICP) is complicated by adverse fetal outcomes and even fetal death, the mechanism remains unclear. This study aims at evaluating the differential expression of mTORC2-AKT-IP3R signaling pathway, which accurately regulate Ca2+ transfer across mitochondria-associated membranes (MAMs) and determine the stress intensity experienced by endoplasmic reticulum (ER) and mitochondria, in patients diagnosed with ICP. METHODS: We combined western blot analysis and placental immunofluorescence co-localization detection to assess the expression and co-localization of the mTORC2-AKT-IP3R signaling pathway in severe (maternal total bile acid (TBA) levels ≥40 μmol/L) and mild (maternal TBA 10-40 μmol/L) ICP...
April 28, 2023: Journal of Perinatal Medicine
https://read.qxmd.com/read/37054625/swath-proteomics-analysis-of-placental-tissue-with-intrahepatic-cholestasis-of-pregnancy
#8
JOURNAL ARTICLE
Yuxuan Jiang, Xiaoping Yin, Qian Xu, Xiaoxiao Tang, Huajie Zhang, Xueshan Cao, Jing Lin, Yi Wang, Fei Yang, Naseer Ullah Khan, Liming Shen, Danqing Zhao
INTRODUCTION: Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the second and third trimesters. The disease's etiology and diagnostic criteria are currently unknown. Based on a sequence window to obtain all theoretical fragment ions (SWATH) proteomic approach, this study sought to identify potential proteins in placental tissue that may be involved in the pathogenesis of ICP and adverse fetal pregnancy outcomes. METHODS: The postpartum placental tissue of pregnant women with ICP were chosen as the case group (ICP group) (subdivided into mild ICP group (MICP group) and severe ICP group (SICP group)), and healthy pregnant women were chosen as the control group (CTR)...
April 8, 2023: Placenta
https://read.qxmd.com/read/37023984/intrahepatic-cholestasis-of-pregnancy-and-fetal-cardiac-dysfunction-a-systematic-review-and-meta-analysis
#9
REVIEW
Yongchi Zhan, Tingting Xu, Tiantian Chen, Xixi Deng, Yao Kong, Yaqian Li, Xiaodong Wang
OBJECTIVE: Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes. Fetal cardiac dysfunction may be 1 part of the pathophysiology of pregnancies complicated by intrahepatic cholestasis of pregnancy. This systematic review and meta-analysis aimed to evaluate the association between intrahepatic cholestasis of pregnancy and fetal cardiac dysfunction. DATA SOURCES: Systematic searches were performed on the databases of Medline, Embase, and Cochrane Library (up to March 2, 2023) for studies evaluating fetal cardiac function in pregnancies complicated by intrahepatic cholestasis of pregnancy in addition to the reference lists of included studies...
April 5, 2023: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/36908062/fetuin-b-may-be-a-potential-marker-for-predicting-maternal-and-neonatal-outcomes-in-intrahepatic-cholestasis-prospective-case-control-study
#10
JOURNAL ARTICLE
Jasmina Begum, Sweta Singh, Gautom Kumar Saharia, Manas Kumar Panigrahi
OBJECTIVE: To investigate the levels of serum fetuin B in healthy pregnant women and women with intrahepatic cholestasis of pregnancy (IHCP) and their association with pregnancy outcomes. MATERIALS AND METHODS: This was a prospective case-control study, we included sixty singleton pregnant women with IHCP and sixty healthy-matched pregnant women in their third trimester. The serum fetuin B levels of these patients were analyzed. All the patients were followed up prospectively until delivery and data related to maternal, perinatal, and neonatal outcomes were obtained...
March 10, 2023: Turkish Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/36359589/bile-acids-in-intrahepatic-cholestasis-of-pregnancy
#11
REVIEW
Maciej Majsterek, Magdalena Wierzchowska-Opoka, Inga Makosz, Lena Kreczyńska, Żaneta Kimber-Trojnar, Bożena Leszczyńska-Gorzelak
Intrahepatic cholestasis of pregnancy (ICP) is the most common, reversible, and closely related to pregnancy condition characterized by elevated levels of bile acids (BAs) in blood serum and an increased risk of adverse perinatal outcomes. Due to the complex interactions between the mother and the fetus in metabolism and transplacental BAs transport, ICP is classified as a fetal-maternal disease. The disease is usually mild in pregnant women, but it can be fatal to the fetus, leading to numerous complications, including intrauterine death...
November 9, 2022: Diagnostics
https://read.qxmd.com/read/36177364/occurrence-of-liver-damage-and-obstetric-outcomes-in-pregnant-women-diagnosed-with-pruritus-during-pregnancy-a-retrospective-study
#12
JOURNAL ARTICLE
Ena Pavelic, Vladimir Blagaic, Paulo Zekan, Petra Glad Stritof, Mara Bebek, Josko Bilandzic, Milan Pavlovic, Mihovil Herceg
Aim: A retrospective study of the occurrence of liver damage and obstetric outcomes in pregnant women diagnosed with pruritus. Methods: The following parameters were monitored in patients: aspartate aminotransferase (AST), alanine aminotransferase, gamma-glutamyl transferase, bilirubin (direct and total), hemoglobin, platelets, serum bile acid level, age of pregnant women, parity, pregnancy weight gain, birth weight, and gestational age at delivery. A total of 107 patients were included during a five-year period (2016-2020) and classified into three groups...
2022: International Journal of Clinical Practice
https://read.qxmd.com/read/36104763/application-of-metabolomics-in-intrahepatic-cholestasis-of-pregnancy-a-systematic-review
#13
REVIEW
Zhuoqiao Yang, Mengxin Yao, Chunhua Zhang, Xuan Hu, Yi Zhong, Xiangxiang Xu, Jieyun Yin
BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) is a severe idiopathic disorder of bile metabolism; however, the etiology and pathogenesis of ICP remain unclear. AIMS: This study comprehensively reviewed metabolomics studies related to ICP, to help in identifying the pathophysiological changes of ICP and evaluating the potential application of metabolomics in its diagnosis. METHODS: Relevant articles were searched through 2 online databases (PubMed and Web of Science) from January 2000 to March 2022...
September 14, 2022: European Journal of Medical Research
https://read.qxmd.com/read/35896403/steroid-metabolome-and-multiple-pregnancy
#14
JOURNAL ARTICLE
Andrej Černý, Zdeněk Laštůvka, Martin Hill, Antonín Pařízek
Steroid biosynthesis occurs in adrenal, gonadal, brain, liver, and placental tissues. Depending on the location of their activity, steroids can be divided into two groups - intracellular and extracellular. Intracellular ones act as transcription factors, suppressing or activating gene expression - they have a so-called genomic effect and therefore their onset of action is slow. Steroids acting extracellularly (non-genome effect) bind to neurotransmitter receptors located on the cytoplasmic cell membrane and thus affect the permeability of the ion channels, the effect of which is much faster, and we refer to them as neuroactive steroids or neurosteroids...
2022: Ceská Gynekologie
https://read.qxmd.com/read/35812382/immune-dysfunction-mediated-by-the-cerna-regulatory-network-in-human-placenta-tissue-of-intrahepatic-cholestasis-pregnancy
#15
JOURNAL ARTICLE
Yuya Wang, Yan Tang, Xianli Yang, Jie Xu, Yanjie Chen, Jing Xu, Shan Hu, Ping Yi
Pregnancy-related intrahepatic cholestasis (ICP) is a serious complication with adverse perinatal outcomes of preterm labor, fetal distress, or stillbirth. As a result, it is important to investigate and identify the potential critical pathogenic mechanisms of ICP. First, we collected the placental tissues from the ICP with placental weight and fetal birth weight loss for the whole transcriptome sequencing. Then we analyzed the differentially expressed (DE) circRNAs (DEcircRNAs) by SRPBM, DElncRNAs by FRKM, DEmiRNAs by TPM, and DEmRNAs by TPM and RSEM...
2022: Frontiers in Immunology
https://read.qxmd.com/read/35762044/serum-profiles-of-inflammatory-cytokines-associated-with-intrahepatic-cholestasis-of-pregnancy
#16
JOURNAL ARTICLE
Shijia Huang, Yang Liu, Nafei Guo, Xiaosong Liu, Guohua Li, Qiaoling Du
BACKGROUND: The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) is not clear, and some researchers have compared the differences in serum levels of inflammatory cytokines between ICP patients and normal pregnant women, but there are few studies and different conclusions. AIM: To investigate the levels of inflammatory cytokines such as interleukins (IL) -4, IL-6, IL-8, and tumor necrosis factor alpha (TNF-α) in patients with ICP and their potential role in pathophysiology...
December 2022: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/35547439/placental-abruption-and-partial-placental-prolapse-during-induction-of-labor-in-a-31-year-old-female-with-intrahepatic-cholestasis-of-pregnancy-a-case-report
#17
Maurice H Dick, Monique Brotman
Placental abruption during induction of labor in females with intrahepatic cholestasis of pregnancy is not exceptionally common and there are no documented reports of placental prolapse following abruption in the literature. The aim of this study is to discuss the possibility of placental abruption and partial prolapse of a low-lying placenta during a prolonged induction of labor in a female with recurrent intrahepatic cholestasis of pregnancy following a cholecystectomy. We describe a 31-year-old G4P3003 female with recurrent intrahepatic cholestasis of pregnancy, with no family history of the condition and surgical history of cholecystectomy, whose induction of labor at 37+3/7 gestational weeks for intrahepatic cholestasis of pregnancy was complicated by placental abruption and partial prolapse of the low-lying placenta...
April 2022: Curēus
https://read.qxmd.com/read/35482784/role-of-vitamin-b12-and-vitamin-d-levels-in-intrahepatic-cholestasis-of-pregnancy-and-correlation-with-total-bile-acid
#18
JOURNAL ARTICLE
Sebahattin Celik, Hakan Golbasi, Selim Gulucu, Mehmet Guclu, Canan Soyer Caliskan, Samettin Celik, Yasam Kemal Akpak, Ceren Golbasi
This study aimed to evaluate the relationship between intrahepatic cholestasis of pregnancy (ICP) and Vitamin D and B12 levels. The study was a retrospective, cross-sectional, case-control study that evaluated 92 ICP cases and 102 pregnant women without any additional disease. ICP cases were grouped as mild and severe according to their total bile acid (TBA) levels, and their relationship with Vitamin D and B12 levels and perinatal outcomes was evaluated. Vitamin D and B12 levels of the ICP group were significantly lower than those of the control group...
August 2022: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://read.qxmd.com/read/35365964/a-new-biomarker-neuropeptide-y-and-bioinformatics-analysis-of-intrahepatic-cholestasis-of-pregnancy
#19
JOURNAL ARTICLE
Fan Feng, Di Xu, Yong Shao
AIM: To explore the expression of neuropeptide Y (NPY) and bioinformatics characteristics of intrahepatic cholestasis of pregnancy (ICP). METHODS: Gene chip data of intrahepatic cholestasis of pregnancy were searched from the GEO database with bioinformatics method, and GSE46157 gene chip was downloaded. Differentially expressed genes in normal pregnant placenta tissue and ICP pregnant placenta tissue (bile acid concentration > 40 μmol/L) were screened by GEO2R...
July 2022: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/35310863/unfolding-newer-concepts-in-placental-pathology-of-obstetric-cholestasis-a-cause-for-prematurity
#20
REVIEW
Anusha Devalla, Kriti Srivastava
Intrahepatic cholestasis of pregnancy (ICP) has an increased predisposition to occur in the third trimester of pregnancy and has a varied population incidence rates due to genetic influences. Owing to the adverse and unpredictable fetal outcomes, it poses a serious therapeutic challenge to the clinician. A rise in the incidence of iatrogenic prematurity has been observed, raising concerns over the perinatal outcomes. Excess bile acids and altered placental transport mechanisms have been strongly implicated in the pathogenesis of ICP and its complications...
2022: International Journal of Physiology, Pathophysiology and Pharmacology
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