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JOURNAL ARTICLE
W Dean Pontius, Ellen S Hong, Zachary J Faber, Jeremy Gray, Craig D Peacock, Ian Bayles, Katreya Lovrenert, Diana H Chin, Berkley E Gryder, Cynthia F Bartels, Peter C Scacheri
The metastasis-invasion cascade describes the series of steps required for a cancer cell to successfully spread from its primary tumor and ultimately grow within a secondary organ. Despite metastasis being a dynamic, multistep process, most omics studies to date have focused on comparing primary tumors to the metastatic deposits that define end-stage disease. This static approach means we lack information about the genomic and epigenomic changes that occur during the majority of tumor progression. One particularly understudied phase of tumor progression is metastatic colonization, during which cells must adapt to the new microenvironment of the secondary organ...
November 8, 2023: Nature Communications
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JOURNAL ARTICLE
Ian H Harding, Joanne Ryan, Stephane Heritier, Simone Spark, Zachary Flanagan, Richard McIntyre, Craig S Anderson, Sharon L Naismith, Trevor T-J Chong, Michael O'Sullivan, Gary Egan, Meng Law, Sophia Zoungas
INTRODUCTION: Cerebrovascular disease and neurodegeneration are causes of cognitive decline and dementia, for which primary prevention options are currently lacking. Statins are well-tolerated and widely available medications that potentially have neuroprotective effects. The STAREE-Mind Imaging Study is a randomised, double-blind, placebo-controlled clinical trial that will investigate the impact of atorvastatin on markers of neurovascular health and brain atrophy in a healthy, older population using MRI...
2023: BMJ neurology open
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JOURNAL ARTICLE
Tovah Cowan, Zachary B Rodriguez, Gregory P Strauss, Ian M Raugh, Alex S Cohen
Blunted affect is associated with severe mental illness, particularly schizophrenia. Mechanisms of blunted affect are poorly understood, potentially due to a lack of phenomenological clarity. Here, we examine clinician rated blunted affect and computerized facial metrics derived from ambulatory video assessment using machine learning. With high predictive accuracy (80-82%), we found that head orientation, eye movement, and facets of mouth movement were associated with clinical ratings of blunted affect. Features denoting larger muscle movements were associated with social cognition (R2 = 0...
October 25, 2023: European Archives of Psychiatry and Clinical Neuroscience
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JOURNAL ARTICLE
Jerry Guintivano, Enda M Byrne, Jacqueline Kiewa, Shuyang Yao, Anna E Bauer, Karolina A Aberg, Mark J Adams, Archie Campbell, Megan L Campbell, Karmel W Choi, Elizabeth C Corfield, Alexandra Havdahl, Donald Hucks, Nastassja Koen, Yi Lu, Merete L Mægbæk, Jimmy Mullaert, Roseann E Peterson, Laura M Raffield, Hannah M Sallis, Julia M Sealock, Alicia Walker, Hunna J Watson, Ying Xiong, Jessica M K Yang, Richard J L Anney, Katherine Gordon-Smith, Leon Hubbard, Lisa A Jones, Raluca Mihaescu, Mette Nyegaard, Antonio F Pardiñas, Amy Perry, Nazmus Saquib, Aladdin H Shadyab, Alexander Viktorin, Ole A Andreassen, Tim B Bigdeli, Lea K Davis, Cindy-Lee Dennis, Arianna Di Florio, Caroline Dubertret, Yen-Chen A Feng, Benicio N Frey, Sophie Grigoriadis, Emilie Gloaguen, Ian Jones, James L Kennedy, Holly Krohn, Theodora Kunovac Kallak, Yun Li, Nicholas G Martin, Andrew M McIntosh, Jeannette Milgrom, Trine Munk-Olsen, Tim Oberlander, Catherine M Olsen, Nicolas Ramoz, Ted Reichborn-Kjennerud, Emma Robertson Blackmore, David Rubinow, Alkistis Skalkidou, Jordan W Smoller, Dan J Stein, Zachary N Stowe, Valerie Taylor, Sarah Tebeka, Martin Tesli, Ryan J Van Lieshout, Edwin J C G van den Oord, Simone N Vigod, Thomas Werge, Lars T Westlye, David C Whiteman, Heather J Zar, Naomi Wray, Samantha Meltzer-Brody, Patrick Sullivan
OBJECTIVE: Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors conducted meta-analyses of genome-wide association studies (GWASs) to investigate the genetic architecture of PPD. METHOD: Meta-analyses were conducted on 18 cohorts of European ancestry (17,339 PPD cases and 53,426 controls), one cohort of East Asian ancestry (975 cases and 3,780 controls), and one cohort of African ancestry (456 cases and 1,255 controls), totaling 18,770 PPD cases and 58,461 controls...
December 1, 2023: American Journal of Psychiatry
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JOURNAL ARTICLE
George R Marcotte, Matthew J Miller, Hawley E Kunz, Zachary C Ryan, Matthew D Strub, Patrick M Vanderboom, Carrie J Heppelmann, Sarah Chau, Zachary D Von Ruff, Sean P Kilroe, Andrew T McKeen, Jason M Dierdorff, Jennifer I Stern, Karl A Nath, Chad E Grueter, Vitor A Lira, Andrew R Judge, Blake B Rasmussen, K Sreekumaran Nair, Ian R Lanza, Scott M Ebert, Christopher M Adams
Aging and many illnesses and injuries impair skeletal muscle mass and function, but the molecular mechanisms are not well understood. To better understand the mechanisms, we generated and studied transgenic mice with skeletal muscle-specific expression of Growth Arrest and DNA Damage Inducible Alpha (GADD45A), a signaling protein whose expression in skeletal muscle rises during aging and a wide range of illnesses and injuries. We found that GADD45A induced several cellular changes that are characteristic of skeletal muscle atrophy, including a reduction in skeletal muscle mitochondria and oxidative capacity, selective atrophy of glycolytic muscle fibers, and paradoxical expression of oxidative myosin heavy chains despite mitochondrial loss...
October 10, 2023: JCI Insight
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COMMENT
Nadine Ali, Khulat Saqi, Ahran D Arnold, Alejandra A Miyazawa, Daniel Keene, Ji-Jian Chow, Ian Little, Nicholas S Peters, Prapa Kanagaratnam, Norman Qureshi, Fu Siong Ng, Nick W F Linton, David C Lefroy, Darrel P Francis, Phang Boon Lim, Mark A Tanner, Amal Muthumala, Girija Agarwal, Matthew J Shun-Shin, Graham D Cole, Zachary I Whinnett
AIMS: Left bundle branch pacing (LBBP) can deliver physiological left ventricular activation, but typically at the cost of delayed right ventricular (RV) activation. Right ventricular activation can be advanced through anodal capture, but there is uncertainty regarding the mechanism by which this is achieved, and it is not known whether this produces haemodynamic benefit. METHODS AND RESULTS: We recruited patients with LBBP leads in whom anodal capture eliminated the terminal R-wave in lead V1...
October 5, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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JOURNAL ARTICLE
Wael Alqarawi, Rafik Tadros, Jason D Roberts, Christopher C Cheung, Martin S Green, Ian G Burwash, Christian Steinberg, Jeffrey S Healey, Habib Khan, Ciorsti McIntyre, Julia Cadrin-Touringy, Zachary W M Laksman, Christopher S Simpson, Shubhayan Sanatani, Martin Gardner, Paul Angaran, Erkan Ilhan, Mario Talajic, Laura Arbour, Richard Leather, Colette Seifer, Jacqueline Joza, Felicity Lee, Lawrence Lau, Girish Nair, George Wells, Andrew D Krahn
BACKGROUND: There is growing evidence that mitral valve prolapse (MVP) is associated with otherwise unexplained cardiac arrest (UCA). However, reports are hindered by the absence of a systematic ascertainment of alternative diagnoses. OBJECTIVES: This study reports the prevalence and characteristics of MVP in a large cohort of patients with UCA. METHODS: Patients were enrolled following an UCA, defined as cardiac arrest with no coronary artery disease, preserved left ventricular ejection fraction, and no apparent explanation on electrocardiogram...
September 6, 2023: JACC. Clinical Electrophysiology
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JOURNAL ARTICLE
Rebecca Spencer, Kasia Maksym, Kurt Hecher, Karel Maršál, Francesc Figueras, Gareth Ambler, Harry Whitwell, Nuno Rocha Nené, Neil J Sebire, Stefan R Hansson, Anke Diemert, Jana Brodszki, Eduard Gratacós, Yuval Ginsberg, Tal Weissbach, Donald M Peebles, Ian Zachary, Neil Marlow, Angela Huertas-Ceballos, Anna L David
BACKGROUNDSevere, early-onset fetal growth restriction (FGR) causes significant fetal and neonatal mortality and morbidity. Predicting the outcome of affected pregnancies at the time of diagnosis is difficult, thus preventing accurate patient counseling. We investigated the use of maternal serum protein and ultrasound measurements at diagnosis to predict fetal or neonatal death and 3 secondary outcomes: fetal death or delivery at or before 28+0 weeks, development of abnormal umbilical artery (UmA) Doppler velocimetry, and slow fetal growth...
September 15, 2023: Journal of Clinical Investigation
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JOURNAL ARTICLE
Michelle L Boone, Zachary M Portman, Ian Lane, Sujaya Rao
Mounting evidence of bumble bee declines and the listing of the rusty patched bumble bee (Bombus affinis Cresson) as federally endangered in the United States in 2017 and Canada in 2012 has stimulated an interest in monitoring and conservation. Understanding the influence of land use on occupancy patterns of imperiled species is crucial to successful recovery planning. Using detection data from community surveys, we assessed land use associations for 7 bumble bee species in Minnesota, USA, including B. affinis...
September 8, 2023: Environmental Entomology
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JOURNAL ARTICLE
Muhammad Ali, Georgios A Maragkos, Kurt A Yaeger, Alexander J Schupper, Trevor A Hardigan, Vikram Vasan, Braxton R Schuldt, Ian C Odland, Margaret Downes, Jonathan Dullea, Luis C Ascanio, Zachary S Troiani, Nicki Mohammadi, Jacques Lara-Reyna, Robert J Rothrock, Daniel R Lefton, J Mocco, Christopher P Kellner
BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) can rapidly result in cerebral herniation, leading to poor neurologic outcomes or mortality. To date, neither decompressive hemicraniectomy (DH) nor hematoma evacuation have been conclusively shown to improve outcomes for comatose ICH patients presenting with cerebral herniation, with these patients largely excluded from clinical trials. Here we present the outcomes of a series of patients presenting with ICH and radiographic herniation who underwent emergent minimally invasive (MIS) ICH evacuation...
August 23, 2023: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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JOURNAL ARTICLE
Ian Savage-Elliott, Dhruv S Shankar, Zachary I Li, Michael Moore, Kinjal D Vasavada, Berkcan Akpinar, Thomas Youm
PURPOSE: The purpose of this study was to compare hip survivorship and patient-reported outcome measures (PROMs) after primary hip arthroscopy at five-year follow-up between femoroacetabular impingement syndrome (FAIS) patients with radiographic signs of global acetabular retroversion versus those without. METHODS: A retrospective matched-cohort study was conducted using a single-surgeon hip arthroscopy database. Patients were included if they underwent primary hip arthroscopy for treatment of FAIS, had preoperative hip X-rays, and had minimum five-year follow-up...
August 12, 2023: Arthroscopy
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JOURNAL ARTICLE
Kevin C Flanagan, Jon Earls, Ian Schillebeeckx, Jeffrey Hiken, Rachel L Wellinghoff, Natalie A LaFranzo, Zachary S Bradley, Joey Babbitt, William H Westra, Raymond Hsu, Lincoln Nadauld, Howard Mcleod, Sean D Firth, Brittany Sharp, Josh Fuller, Vera Vavinskaya, Leisa Sutton, Ida Deichaite, Samuel D Bailey, Vlad C Sandulache, Matthew J Rendo, Orlan K Macdonald, Karim Welaya, James L Wade, Andrew W Pippas, Jennifer Slim, Bruce Bank, Steven J Saccaro, Xingwei Sui, Adil Akhtar, Savitha Balaraman, Steven E Kossman, Scott A Sonnier, Todd D Shenkenberg, Warren L Alexander, Katherine A Price, Charles L Bane, Jessica Ley, David N Messina, Jarret I Glasscock, Ezra E W Cohen, Douglas R Adkins, Eric J Duncavage
PURPOSE: Anti-PD-1 therapy provides clinical benefit in 40-50% of patients with relapsed and/or metastatic head and neck squamous cell carcinoma (RM-HNSCC). Selection of anti- PD-1 therapy is typically based on patient PD-L1 immunohistochemistry (IHC) which has low specificity for predicting disease control. Therefore, there is a critical need for a clinical biomarker that will predict clinical benefit to anti-PD-1 treatment with high specificity. METHODS: Clinical treatment and outcomes data for 103 RM-HNSCC patients were paired with RNA-sequencing data from formalin-fixed patient samples...
August 8, 2023: Journal of Cancer Research and Clinical Oncology
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JOURNAL ARTICLE
Peter Tugwell, Vivian Welch, Olivia Magwood, Alex Todhunter-Brown, Elie A Akl, Thomas W Concannon, Joanne Khabsa, Richard Morley, Holger Schunemann, Lyubov Lytvyn, Arnav Agarwal, Alba Antequera, Marc T Avey, Pauline Campbell, Christine Chang, Stephanie Chang, Leonila Dans, Omar Dewidar, Davina Ghersi, Ian D Graham, Glen Hazlewood, Jennifer Hilgart, Tanya Horsley, Denny John, Janet Jull, Lara J Maxwell, Chris McCutcheon, Zachary Munn, Francesco Nonino, Jordi Pardo Pardo, Roses Parker, Kevin Pottie, Gabriel Rada, Alison Riddle, Anneliese Synnot, Elizabeth Tanjong Ghogomu, Eve Tomlinson, Karine Toupin-April, Jennifer Petkovic
BACKGROUND: Involving collaborators and partners in research may increase relevance and uptake, while reducing health and social inequities. Collaborators and partners include people and groups interested in health research: health care providers, patients and caregivers, payers of health research, payers of health services, publishers, policymakers, researchers, product makers, program managers, and the public. Evidence syntheses inform decisions about health care services, treatments, and practice, which ultimately affect health outcomes...
August 2, 2023: Systematic Reviews
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JOURNAL ARTICLE
Zachary M Portman, Joel Gardner, Ian G Lane, Nicole Gerjets, Jessica D Petersen, John S Ascher, Mike Arduser, Elaine C Evans, Crystal Boyd, Robin Thomson, Daniel P Cariveau
Research studies and conservation actions aimed at improving conditions for bees require a basic understanding of which species are present in a given region. The US state of Minnesota occupies a unique geographic position at the confluence of eastern deciduous forests, northern boreal forests, and western tallgrass prairie, which has led to a diverse and unique bee fauna. In recent years there have been multiple ongoing bee-focused inventory and research projects in Minnesota. Combined with the historic specimens housed in the University of Minnesota Insect Collection and other regional collections, these furnished a wealth of specimens available to form the basis of a statewide checklist...
June 16, 2023: Zootaxa
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JOURNAL ARTICLE
Lilit Karapetyan, Hassan M AbuShukair, Aofei Li, Andrew Knight, Ayah Nedal Al Bzour, Ian P MacFawn, Zachary J Thompson, Ann Chen, Xi Yang, Rebekah Dadey, Arivarasan Karunamurthy, Danielle Vargas De Stefano, Cindy Sander, Sheryl R Kunning, Yana G Najjar, Diwakar Davar, Jason J Luke, William Gooding, Tullia C Bruno, John M Kirkwood, Walter J Storkus
BACKGROUND: Proinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME). In the current study, we sought to investigate the prognostic value of TLS-associated chemokines/cytokines (TLS-kines) expression levels in melanoma patients by performing serum protein and tissue transcriptomic analyses, and to then correlate these data with patients clinicopathological and TME characteristics. METHODS: Levels of TLS-kines in patients' sera were quantitated using a custom Luminex Multiplex Assay...
2023: Frontiers in Immunology
#36
JOURNAL ARTICLE
Megan D Hopkins, Ian J Costello, Zachary C Brandeburg, Emily L Slay, Levi A Zanders, Caroline E Dunn, Carina A Derewonko, Colin L Davitt, Madison A Reeder, Kate Prichard, Beatrice Chiew, Adam McCluskey, Robert J Sheaff, Angus A Lamar
In an effort to further investigate previously observed activity of indolyl sulfonamides towards pancreatic cancer cell lines, a library of 44 compounds has been synthesized. The biological activity of the compounds has been determined using two different screening assay techniques against 7 pancreatic cancer cell lines and 9 non-pancreatic cancer cell lines. In the first assay, the cytotoxicity of the compounds was evaluated using a traditional (48 hour compound exposure) method. An in silico investigation was conducted to determine if the compounds might be inducing cell death by inhibiting the S100A2-p53 protein-protein interaction...
July 8, 2023: ChemMedChem
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JOURNAL ARTICLE
Shane M Breznak, Yingshi Peng, Limin Deng, Noor M Kotb, Zachary Flamholz, Ian T Rapisarda, Elliot T Martin, Kara A LaBarge, Dan Fabris, Elizabeth R Gavis, Prashanth Rangan
Stem cells in many systems, including Drosophila germline stem cells (GSCs), increase ribosome biogenesis and translation during terminal differentiation. Here, we show that the H/ACA small nuclear ribonucleoprotein (snRNP) complex that promotes pseudouridylation of ribosomal RNA (rRNA) and ribosome biogenesis is required for oocyte specification. Reducing ribosome levels during differentiation decreased the translation of a subset of messenger RNAs that are enriched for CAG trinucleotide repeats and encode polyglutamine-containing proteins, including differentiation factors such as RNA-binding Fox protein 1...
June 23, 2023: Science Advances
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JOURNAL ARTICLE
Timothy A McCaffrey, Ian Toma, Zhaoqing Yang, Richard Katz, Jonathan Reiner, Ramesh Mazhari, Palak Shah, Zachary Falk, Richard Wargowsky, Jennifer Goldman, Dan Jones, Dmitry Shtokalo, Denis Antonets, Tisha Jepson, Anastasia Fetisova, Kevin Jaatinen, Natalia Ree, Maxim Ri
BACKGROUND: Cardiovascular disease had a global prevalence of 523 million cases and 18.6 million deaths in 2019. The current standard for diagnosing coronary artery disease (CAD) is coronary angiography either by invasive catheterization (ICA) or computed tomography (CTA). Prior studies employed single-molecule, amplification-independent RNA sequencing of whole blood to identify an RNA signature in patients with angiographically confirmed CAD. The present studies employed Illumina RNAseq and network co-expression analysis to identify systematic changes underlying CAD...
June 2023: J Mol Cell Cardiol Plus
#39
REVIEW
Jason J Nam, An-Kwok Ian Wong, David Cantong, John Alexander Cook, Zachary Andrews, Jerrold H Levy
Coagulopathy can occur in trauma, and it can affect septic patients as a host tries to respond to infection. Sometimes, it can lead to disseminated intravascular coagulopathy (DIC) with a high potential for mortality. New research has delineated risk factors that include neutrophil extracellular traps and endothelial glycocalyx shedding. Managing DIC in septic patients focuses on first treating the underlying cause of sepsis. Further, the International Society on Thrombolysis and Haemostasis (ISTH) has DIC diagnostic criteria...
June 23, 2023: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
#40
JOURNAL ARTICLE
Shayla M J Overstreet, Ian M Genzia, Alexander Nguyen, Zachary J Auleciems, Abby R Jennings, Andrew J Peloquin
In the title compound, C11 H10 F4 N2 O2 , the conformation about the N-C-C-O bond is gauche [torsion angle = 61.84 (13)°]. In the crystal, N-H⋯O hydrogen bonds link the mol-ecules into [010] chains, which are cross-linked by C-H⋯F and C-H⋯π contacts. Hirshfeld surface analysis was conducted to aid in the visualization of these various influences on the packing. This analysis showed that the largest contribution to the surface contacts arises from F⋯H/H⋯F inter-actions (35...
May 1, 2023: Acta Crystallographica. Section E, Crystallographic Communications
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