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https://www.readbyqxmd.com/read/29334307/regorafenib-regresses-an-imatinib-resistant-recurrent-gastrointestinal-stromal-tumor-gist-with-a-mutation-in-exons-11-and-17-in-a-patient-derived-orthotopic-xenograft-pdox-nude-mouse-model
#1
Kentaro Miyake, Kei Kawaguchi, Tasuku Kiyuna, Masuyo Miyake, Kentaro Igarashi, Zhiying Zhang, Takashi Murakami, Yunfeng Li, Scott D Nelson, Irmina Elliott, Tara Russell, Arun Singh, Yukihiko Hiroshima, Masashi Momiyama, Ryusei Matsuyama, Takashi Chisima, Itaru Endo, Fritz C Eilber, Robert M Hoffman
Gastrointestinal stromal tumor (GIST) is a rare type of sarcoma. The aim of this study was to determine drug sensitivity for a regionally-recurrent case of GIST using a patient-derived orthotopic xenograft (PDOX) model. The PDOX model was established in the anterior wall of the stomach. GIST PDOX models were randomized into 5 groups of 6 mice each when the tumor volume reached 60 mm3: G1, control group; G2, imatinib group (oral administration (p.o.), daily, for 3 weeks); G3, sunitinib group (p.o., daily, for 3 weeks); G4, regorafenib (p...
January 15, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29332066/correlation-between-serum-calcineurin-activity-and-left-ventricular-hypertrophy-in-hypertensive-patients-and-its-clinical-significance
#2
Jia-Li Cao, Yu-Qing Yang, Dookhun Muhammad Nabeel, Ya-Li Sun, Hua-Yi-Yang Zou, Xiang-Qing Kong, Xin-Zheng Lu
OBJECTIVE: The aim of this study is to investigate the correlation between calcineurin (CaN) and hypertension with left ventricular hypertrophy (HLVH) and to evaluate its potential clinical significance. DESIGN: The study involved 160 patients diagnosed with hypertension and 42 controls. Based on the exclusion criteria, 42 were not eligible for this study. The remaining 118 hypertensive patients were categorized into 2 subgroups based on left ventricular mass index and relative ventricular wall thickness: a normal model subgroup with hypertension (HNM) and an HLVH subgroup...
January 13, 2018: Cardiology
https://www.readbyqxmd.com/read/29329370/defining-normal-parameters-for-the-male-nipple-areola-complex-a-prospective-observational-study-and-recommendations-for-placement-on-the-chest-wall
#3
Dominic Yue, Lilli R L Cooper, Ryan Kerstein, Susan C Charman, Norbert V Kang
Background: The nipple-areola complex (NAC) is important aesthetically and functionally for both sexes. Methods for positioning the NAC in males are less well established in the literature compared to females but are just as important. Objectives: This study aims to determine the normal parameters for the male NAC, to review literature, and to present a reliable method for preoperative placement. Methods: Normal male patients, with no prior chest wall conditions, were prospectively recruited to participate...
January 10, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29326826/collision-tumor-consisting-of-a-colorectal-adenocarcinoma-and-dissemination-of-a-gastric-adenocarcinoma
#4
Ryoichi Miyamoto, Kazunori Kikuchi, Atsushi Uchida, Masayoshi Ozawa, Akira Kemmochi, Naoki Sano, Sosuke Tadano, Satoshi Inagawa, Shinya Adachi, Masayoshi Yamamoto
Background: Collision tumors, composed of histologically distinct tumor types, are rare entities, especially in the colorectum, and corresponding evidence-based clinical management or treatment strategies are poorly defined. This is the first report of a collision tumor composed of two histologically distinct adenocarcinomas. Case presentation: A 78-year-old male showed severe anemia and a 10% body weight loss over 1 month. Preoperative examination revealed T3N1M0 stage IIIA gastric cancer and T3N0M0 stage IIA rectal cancer...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29326777/surgical-treatment-of-right-ventricular-rupture-caused-by-total-occlusion-of-the-right-coronary-artery
#5
Mihriban Yalcin, Diyar Koprulu, Melih Urkmez, Mehmet Senel Bademci
The rupture of the right ventricular anterior wall after myocardial infarction is a rare and life-threatening complication associated with high mortality. Early diagnosis by echocardiographic examination and successful treatment is discussed in this case report.
October 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/29325984/minimally-invasive-repair-of-pectus-carinatum
#6
Mustafa Yuksel, Tunc Lacin, Nezih Onur Ermerak, Esra Yamansavci Sirzai, Bihter Sayan
BACKGROUND: The second most common deformity of the anterior chest wall, pectus carinatum, is a diverse deformity that has been largely managed using open techniques. This study reviews clinical experience with a newly designed bar for minimally invasive repair of pectus carinatum. METHODS: We reviewed the records of all patients recorded in our Chest Wall Deformities Clinical Database. Between January 2006 and November 2016, minimally invasive repair of pectus carinatum was performed in 172 patients...
January 9, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29325364/-the-efficacy-and-safety-of-coil-embolization-of-septal-branch-in-the-treatment-of-patients-with-obstructive-hypertrophic-cardiomyopathy
#7
H Liu, Q Wu, H W Tan, J Pang
Objective: To observe the clinical efficacy and safety of coil embolization of septal branch in the treatment of obstructive hypertrophic cardiomyopathy (HOCM). Methods: Eighteen patients with HOCM hospitalized in our department from September 2014 to October 2016 were enrolled in this study. There were 12 males and 6 females in this cohort and the age of patients ranged from 22 to 64 years old. Left ventricular outflow tract gradient (LVOTG) was derived from echocardiographic apical five-chamber view at pre-operation and at 48 hours and 6 months post operation...
December 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29322214/protective-role-of-nrf2-against-mechanical-stretch-induced-apoptosis-in-mouse-fibroblasts-a-potential-therapeutic-target-of-mechanical-trauma-induced-stress-urinary-incontinence
#8
Qiannan Li, Bingshu Li, Cheng Liu, Linlin Wang, Jianming Tang, Li Hong
INTRODUCTION AND HYPOTHESIS: We investigated the protective effect and underlying molecular mechanism of nuclear factor-E2-related factor 2 (Nrf2) against mechanical-stretch-induced apoptosis in mouse fibroblasts. METHODS: Normal cells, Nrf2 silencing cells, and Nrf2 overexpressing cells were respectively divided into two groups-nonintervention and cyclic mechanical strain (CMS)-subjected to CMS of 5333 μ (1.0 Hz for 4 h), six groups in total (control, CMS, shNfe212, shNfe212 + CMS, LV-shNfe212, and LV-shNfe212 + CMS)...
January 10, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29321434/tricuspid-and-mitral-valve-regurgitation-with-bi-fascicular-block-following-a-horse-kick
#9
Tomoki Kokubun, Masayoshi Oikawa, Yasuhiro Ichijo, Yoshiyuki Matsumoto, Tetsuro Yokokawa, Kazuhiko Nakazato, Yoshiyuki Sato, Shinya Takase, Hiroharu Shinjo, Hitoshi Yokoyama, Hitoshi Suzuki, Shu-Ichi Saitoh, Yasuchika Takeishi
A 40-year-old man was transferred to our hospital following an isolated horse kick injury to the anterior chest wall. The case showed bi-fascicular block, severe tricuspid valve regurgitation due to ruptured chordae tendineae of the anterior leaflet, moderate mitral valve regurgitation due to prolapse of mitral anterior leaflet, and hypokinetic motion of the inferior septal wall. Both tricuspid and mitral insufficiency were completely repaired by a surgical operation. Fortunately, these injuries were not fatal in this case, but the comprehensive assessment of cardiac damage and careful observation are important for managing patients with cardiac injury...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29321239/comparative-genomic-analysis-of-the-pseudofungus-hyphochytrium-catenoides
#10
Guy Leonard, Aurélie Labarre, David S Milner, Adam Monier, Darren Soanes, Jeremy G Wideman, Finlay Maguire, Sam Stevens, Divya Sain, Xavier Grau-Bové, Arnau Sebé-Pedrós, Jason E Stajich, Konrad Paszkiewicz, Matthew W Brown, Neil Hall, Bill Wickstead, Thomas A Richards
Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. The Fungi successfully coupled osmotrophy with filamentous growth, and similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives...
January 2018: Open Biology
https://www.readbyqxmd.com/read/29315411/improving-procedural-and-one-year-outcome-after-contact-force-guided-pulmonary-vein-isolation-the-role-of-interlesion-distance-ablation-index-and-contact-force-variability-in-the-close-protocol
#11
Thomas Phlips, Philippe Taghji, Milad El Haddad, Michael Wolf, Sébastien Knecht, Yves Vandekerckhove, René Tavernier, Mattias Duytschaever
Aims: We have recently shown that a contact force (CF)-guided ablation protocol respecting region-specific criteria of lesion contiguity and lesion depth ('CLOSE' protocol) is associated with high incidence of acute durable pulmonary vein (PV) isolation (PVI) and a high single-procedure arrhythmia-free survival at 1 year. In the present study, we compared efficiency, safety, and efficacy of 'CLOSE'-guided PVI to conventional CF-guided PVI (CONV-CF). Methods and results: Fifty consecutive paroxysmal atrial fibrillation (AF) patients underwent PV encircling using a CF-sensing catheter targeting an interlesion distance (ILD) ≤6 mm and ablation index (AI) ≥400 and ≥550 at posterior and anterior wall ('CLOSE' group)...
January 4, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29312772/primary-thoracic-extraskeletal-osteosarcoma-a-case-report-and-literature-review
#12
Jie Qian, Xue-Yan Zhang, Ping Gu, Jin-Chen Shao, Bao-Hui Han, Hui-Min Wang
Primary extraskeletal osteosarcoma (ESOS) presenting in thoracic locations is very rare and associated with a poor prognosis. The current study presents a case involving a large anterior mediastinal mass, which was histologically confirmed as a primary osteosarcoma. The literature concerning primary thoracic ESOS is reviewed. A total of 60 cases were identified. The median age was 60 years (range, 14-93 years) and males were more prevalent among the reported cases (65%). Survival analysis revealed that the overall 5-year survival was only 22...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29310702/mondor-s-disease-a-rare-cause-of-chest-pain-a-case-report
#13
Navaneethakrishnan Suganthan, Vithiya Ratnasamy
BACKGROUND: Chest pain is one of the common presenting symptoms encountered in an emergency department. Prompt history taking and careful clinical examination do help to differentiate cardiac chest pain from other causes. Mondor's disease is a rare cause of chest pain which is often underdiagnosed due to lack of awareness. Mondor's disease is a condition characterized by thrombophlebitis of the superficial veins of breast and anterior chest wall. The diagnosis is often made clinically...
January 9, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29310402/a-rare-variation-of-celiac-trunk-and-hepatic-artery-complicating-pancreaticoduodenectomy-a-case-report-and-literature-review
#14
Zhou Ye, Song Ye, Dongkai Zhou, Shusen Zheng, Weilin Wang
RATIONALE: Anatomical variations of the celiac trunk and the hepatic artery are of considerable importance in hepatopancreatobiliary surgery, liver transplants, and radiological abdominal interventions. PATIENT CONCERNS: Here, we report a 57-year-old man with 2 weeks of painless progressive jaundice. Preoperative imaging and cytology brush results suggested an ampullary tumor and common hepatic artery anomaly (CTA) was reported. The patient underwent pancreaticoduodenectomy (PD)...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29306264/management-of-right-main-bronchial-rupture-with-a-double-lumen-endotracheal-tube-in-a-patient-with-blunt-chest-trauma
#15
Seung Hwan Seol, Woon Jeong Lee, Seon Hee Woo, Dae Hui Kim, Jong Hui Suh
Tracheobronchial disruption is one of the most severe injuries caused by blunt chest trauma. It may cause airway obstruction and resulting life-threatening respiratory deficiency. However, the clinical presentations are variable and frequently difficult to diagnose. We report a case of a previously healthy 16-year-old man with complete right main bronchial transection sustained after a vehicular accident, who had progressive dyspnea, subcutaneous emphysema in the neck and anterior chest wall, and bilateral tension pneumothorax...
December 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29305851/quantitative-assessment-of-inflow-malposition-in-two-continuous-flow-left-ventricular-assist-devices
#16
Erik N Sorensen, Zachary N Kon, Erika D Feller, Si M Pham, Bartley P Griffith
BACKGROUND: We previously investigated preoperative variables associated with qualitative inflow cannula (IFC) malposition in the Heartmate II continuous-flow left ventricular assist device. In this report, we assess IFC malposition quantitatively in recipients of both the Heartmate II and the Heartware and examine its association with device thrombosis. METHODS: Malposition was quantified based on angular deviation from a hypothetical ideal IFC position in two orthogonal computed tomography (CT) imaging planes...
January 3, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29305372/uterocutaneous-fistula-following-b-lynch-suture-for-primary-postpartum-haemorrhage
#17
Monika Thakur, Sandeep S Rathore, Aditi Jindal, Kunal Mahajan
A 30-year-old woman, who had undergone emergency lower segment caesarean section (LSCS) for failed induction 2 months back, presented with a fistulous opening along with discharge from her previous incision scar. She had developed a massive primary postpartum haemorrhage at the time of LSCS 2 months back, which was managed with B-Lynch suture and vessel ligation. Fistulogram revealed a connection between the uterus and the skin. The diagnosis was confirmed by a contrast-enhanced CT scan. Patient was subjected to laparotomy...
January 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29305037/transauricular-vagus-nerve-stimulation-at-auricular-acupoints-kindey-co10-yidan-co11-liver-co12-and-shenmen-tf4-can-induce-auditory-and-limbic-cortices-activation-measured-by-fmri
#18
Liyan Peng, Ketao Mu, Aiguo Liu, Liangqiang Zhou, Yueyue Gao, Imrit Tejvansh Shenoy, Zhigang Mei, Qingguo Chen
The purpose of this study was to explore the central mechanism of transauricular vagus nerve stimulation (taVNS) to human by fMRI and to find a suitable taVNS site for potential tinnitus treatment. 24 healthy subjects aged between 28 and 38 years were enrolled in the experiment. 8 subjects were stimulated in the auricular acupoints Kindey (CO10), Yidan (CO11), Liver (CO12) and Shenmen (TF4) in the left ear, 8 subjects were stimulated at the anterior wall of the auditory canal and left lower limb as an anterior stimulation group; 8 persons who were arranged in a sham group received taVNS at the left ear lobe and tail of the helix...
December 24, 2017: Hearing Research
https://www.readbyqxmd.com/read/29302942/pathophysiological-factors-associated-with-left-ventricular-perforation-in-transcatheter-aortic-valve-implantation-by-transfemoral-approach
#19
Tamer Owais, Mohammad El Garhy, Jürgen Fuchs, Kushtrim Disha, Sameh Elkaffas, Martin Breuer, Bernward Lauer, Thomas Kuntze
BACKGROUND: Left ventricular (LV) perforation is one of the rare and most serious complications of transcatheter aortic valve implantation (TAVI). The study aim was to determine the pathophysiological factors associated with this serious complication. METHODS: A retrospective study was conducted of pathophysiological factors shown in echocardiograms and computed tomography angiograms performed preoperatively in patients who developed LV perforation during transfemoral TAVI (study group) with regards to anatomic and functional variables...
July 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29290196/huge-gastric-and-ileal-trichobezoars-causing-small-bowel-obstruction
#20
Muhammad Imran, Ume Sughra, Aurangzeb Khan
The bezoar is the accumulation of undigestible food or fibre in the digestive tract, most commonly in stomach and proximal small bowel. Trichobezoar is an accumulation of hair. They may present as an independent mass in small bowel or with or without an extension into the small bowel. The trichobezoars are well described, in terms of surgical, diagnostic, and therapeutic procedures. However, there are very few reports on psychiatric literature and a dual presentation of gastric and ileal trichobezoars. The authors present a case report of a gastric with an ileal trichobezoar that is rarely reported in literature...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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