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hypothyroidism in pregnancy

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https://www.readbyqxmd.com/read/29774380/-thyroid-and-pregnancy
#1
REVIEW
K A Iwen, H Lehnert
During pregnancy thyroid hormones have profound effects on embryonal/fetal development and maternal health. Therefore, thyroid gland disorders should be immediately diagnosed and adequately treated. Pregnancy-specific physiological alterations during pregnancy cause changes in the reference interval for thyroid-stimulating hormone levels and trimester-specific thresholds must be taken into account. This article summarizes the most important diagnostic and therapeutic aspects before, during and after pregnancy...
May 17, 2018: Der Internist
https://www.readbyqxmd.com/read/29764026/-advances-in-postoperative-thyroid-stimulating-hormone-suppression-therapy-in-females-with-thyroid-cancer
#2
F Song, H L Yi
Differentiated thyroid cancer is the most common malignant carcinoma in female population.Postoperative long-term thyroid-stimulating hormone(TSH) suppression therapy can reduce the risk of recurrence for differentiated thyroid cancer and control the progress of the disease, but it also induces simultaneously subclinical hypothyroidism and imposes negative effect on female. In addition to cardiovascular disease, TSH suppression therapy can lead to the alteration of sex hormone metabolism, menstrual disorder, poor influence on pregnancy and osteoporosis...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29706030/preconception-management-of-thyroid-dysfunction
#3
Onyebuchi E Okosieme, Ishrat Khan, Peter N Taylor
Uncorrected thyroid dysfunction in pregnancy has well recognised deleterious effects on fetal and maternal health. The early gestation period is one of critical fetal vulnerability during which maternal thyroid dysfunction may have lasting repercussions. Accordingly, a pragmatic preconception strategy is key for ensuring optimal thyroid disease outcomes in pregnancy. Preconception planning in women with hypothyroidism should pre-empt and mirror the adaptive changes of the thyroid gland by careful levothyroxine dose adjustments to ensure adequate fetal thyroid hormone delivery in pregnancy...
April 29, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29701867/pregnancy-complications-associated-with-maternal-hypothyroidism-a-systematic-review
#4
Danielle Rosani Shinohara, Thais da Silva Santos, Hayalla Corrêa de Carvalho, Laíza Cristina Bahls Lopes, Luciene Setsuko Akimoto Günther, Sandra Mara Alessi Aristides, Jorge Juarez Vieira Teixeira, Izabel Galhardo Demarchi
Importance: Hypothyroidism is one of the most prevalent diseases in pregnancy, but there is no consensus about its management in pregnant women. Objective: In this systematic review, we evaluated the association between pregnancy complications and treated or untreated maternal hypothyroidism. Evidence Acquisition: PubMed and reference lists were searched for the Medical Subject Headings terms "pregnancy complications" and "hypothyroidism...
April 2018: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/29699957/iodine-deficiency-in-pregnant-women-at-first-trimester-in-ankara
#5
Kazibe Koyuncu, Batuhan Turgay, Feride Söylemez
OBJECTIVE: Iodine deficiency in pregnant woman in Ankara was shown in previous studies. We aimed to conduct a study in a tertiary center to investigate for the need for iodine replacement in our population. MATERIAL AND METHODS: This was a single tertiary center, non-interventional, retrospective, cross-sectional study. Data were retrieved retrospectively from 440 women who had been in first trimester in gestational age. Maternal iodine status, TSH levels, T4 levels were examined...
April 27, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29693263/clinical-associations-of-maternal-thyroid-function-with-fetal-brain-development-epidemiological-interpretation-and-overview-of-available-evidence
#6
Tim I M Korevaar, Henning Tiemeier, Robin P Peeters
TH is an important regulator of metabolism, growth and development in practically all tissues of the human body. During pregnancy, major changes occur in thyroid physiology including an increase in TH binding globulins, an increase in TH degradation by thyroid degrading enzymes (due to placental expression of type 3 deiodinase) and an increase in thyroid stimulation through high concentrations of human chorionic gonadotropin (hCG). Both overt hypothyroidism and Graves' hyperthyroidism, which occur in approximately 0...
April 24, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29674207/impact-of-excessive-pre-pregnancy-body-mass-index-and-abnormal-gestational-weight-gain-on-pregnancy-outcomes-in-women-with-chronic-hypertension
#7
Sara Ornaghi, Paola Algeri, Lyudmyla Todyrenchuk, Emanuela Vertemati, Patrizia Vergani
OBJECTIVES: To investigate the effects of excessive pre-pregnancy body mass index (BMI) and abnormal gestational weight gain on adverse outcomes in women with chronic hypertension (CH). STUDY DESIGN: A retrospective cohort study of CH women with singleton pregnancy delivered at our Institution in 2002-2013. Women were categorized as normal, overweight, and obese, according to their pre-pregnancy BMI. Further stratification was based on gestational weight gain (insufficient, adequate, and excessive) as defined by 2009 IOM guidelines...
April 10, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29669804/subclinical-hypothyroidism-in-pregnant-rats-impaired-learning-and-memory-in-offspring-by-promoting-p75ntr-signaling
#8
Fan Zhang, Jian Chen, Xinyue Lin, Shiqiao Peng, Xiaohui Yu, Zhongyan Shan, Weiping Teng
OBJECTIVE: Maternal hypothyroidism during pregnancy can affect the neurodevelopment of their offspring. This study aimed to investigate the effects of maternal subclinical hypothyroidism (SCH) on spatial learning and memory, and its relationship with the apoptotic factors in cerebral cortex of the offspring. METHODS: Female adult Wistar rats were randomly divided into three groups (n=15 per group): control (CON) group, SCH group and overt hypothyroidism (OH) group...
April 18, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29662962/the-relation-of-maternal-hypothyroidism-and-hypothyroxinemia-during-pregnancy-on-preterm-birth-an-updated-systematic-review-and-meta-analysis
#9
REVIEW
Marzieh Parizad Nasirkandy, Gholamreza Badfar, Masoumeh Shohani, Shoboo Rahmati, Mohammad Hossein YektaKooshali, Shamsi Abbasalizadeh, Ali Soleymani, Milad Azami
Background: The clinical consequences of hypothyroidism and hypothyroxinemia during pregnancy such as preterm birth are not still clear. Objective: The aim of this meta-analysis was to estimate the relation of clinical and subclinical hypothyroidism and hypothyroxinemia during pregnancy and preterm birth. Materials and Methods: In this meta-analysis, Preferred Reporting Items for Systematic review and Meta-Analysis were utilized. Searching the cohort studies were done by two researchers independently without any restrictions on Scopus, PubMed, Science Direct, Embase, Web of Science, CINAHL, Cochrane, EBSCO and Google Scholar databases up to 2017...
September 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29644934/management-of-subclinical-hypothyroidism-in-pregnancy-a-comment-from-the-italian-society-of-endocrinology-sie-and-the-italian-thyroid-association-ait-to-the-2017-ata-guidelines-the-italian-way
#10
Mario Rotondi, Luca Chiovato, Furio Pacini, Luigi Bartalena, Paolo Vitti
The 2017 ATA Guidelines for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum were published six years after the previous ones. They provide comprehensive clinical recommendations for the whole spectrum of thyroid diseases as well as for optimal iodine intake during pregnancy, post-partum and lactation. The present position statement mainly regards the recommended flow-chart for therapeutic decision making in pregnant women being diagnosed with subclinical hypothyroidism. The major biochemical and clinical situations and the corresponding therapeutic indications will be commented...
April 12, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29619339/abortion-may-be-associated-with-elevated-risk-of-future-hypothyroidism
#11
Vivek Chauhan, Anurag Thakur, Gurudutt Sharma
Objective: Fetal microchimerism during pregnancy and abortion has been linked with autoimmune hypothyroidism in females. We conducted a case-control study to investigate the odds of "abortion in the past" in the newly diagnosed hypothyroid females compared to their age-matched euthyroid controls. Methods: All consecutive newly diagnosed hypothyroid females, over 1 year, were enrolled as cases. Age-matched euthyroid controls were selected from the same region...
January 2018: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29605392/prediction-of-neonatal-hyperthyroidism
#12
Maïa Banigé, Michel Polak, Dominique Luton
OBJECTIVES: To assess whether it is possible to identify the neonatal predictors of neonatal hyperthyroidism at the presymptomatic stage of the disease. STUDY DESIGN: This retrospective multicenter study in 10 maternity units was based on the medical records of all patients monitored for a pregnancy between January 1, 2007, and January 1, 2014. Among 280 000 births, 2288 medical records of women with thyroid dysfunction were selected and screened. Of these, 415 women had Graves disease and were positive for thyrotropin receptor antibody during pregnancy, and were included...
March 28, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29584590/maternal-thyroid-function-in-early-pregnancy-and-child-neurodevelopmental-disorders-a-danish-nationwide-case-cohort-study
#13
Stine Linding Andersen, Stig Andersen, Peter Vestergaard, Jørn Olsen
BACKGROUND: Maternal thyroid dysfunction may adversely affect fetal brain development, but more evidence is needed to refine this hypothesis. The aim of this study was to evaluate potential fetal programming by abnormal maternal thyroid function on child neurodevelopmental disorders. METHODS: The design was a case-cohort study within the Danish National Birth Cohort (1997-2003). From the eligible cohort of 71,706 women, a random 12% sub-cohort (n = 7624) was selected, and all women (n = 2276) whose child was diagnosed with seizures, specific developmental disorder (SDD), autism spectrum disorder (ASD), and/or attention-deficit/hyperactivity disorder (ADHD) up to December 31, 2010, were identified...
April 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29560762/initiation-timing-effect-of-levothyroxine-treatment-on-subclinical-hypothyroidism-in-pregnancy
#14
Lijie Zhao, Guojing Jiang, Xingfang Tian, Xiaoqin Zhang, Ting Zhu, Beibei Chen, Yongxiang Wang, Qingliang Ma
The aim of this study is to estimate the timing impact on levothyroxine replacement among pregnant women with subclinical hypothyroidism (SCH). Ninety-eight pregnant women diagnosed as SCH in the first trimester were randomly divided into three groups: Group A, instantly initiated levothyroxine after diagnosis; Group B, administrated treatment in the second trimester, and Group C, received no prescription. Incidence of pregnancy complications and pregnancy outcomes were compared among three groups and subgroup analysis were performed stratified with TPO status in Group B...
March 21, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29544795/associations-of-maternal-iodine-status-and-thyroid-function-with-adverse-pregnancy-outcomes-in-henan-province-of-china
#15
Jin Yang, Yang Liu, Hongjie Liu, Heming Zheng, Xiaofeng Li, Lin Zhu, Zhe Wang
OBJECTIVE: The study aimed to explore the effects of maternal iodine status and thyroid diseases on adverse pregnancy outcomes. METHODS: A prospective study was conducted on 2347 pregnant women, who provided 2347 urinary samples tested for iodine, 1082 serum samples tested for thyroid function, and 2347 questionnaires about demographic information. Their pregnancy outcomes were recorded and compared between different urinary iodine concentration (UIC) and thyroid function groups...
May 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29543303/prevalence-of-subclinical-hypothyroidism-in-pregnancy-in-saudi-arabia
#16
Shatha A Al Shanqeeti, Yasser N Alkhudairy, Alwaleed A Alabdulwahed, Anwar E Ahmed, Maysoon S Al-Adham, Naveed M Mahmood
To estimate the prevalence of subclinical hypothyroidism (SCH) in Saudi Arabia and assess the need for an SCH screening program. Methods: This cross-sectional study was conducted at King Abdulaziz Medical City and the Khashmulaan Clinic at the National Guard Health Affairs, Riyadh, Saudi Arabia in August 2016. All women attending the antenatal clinics were  invited to participate in the study. In addition, data were retrieved from the files of pregnant women who had been screened for hypothyroidism from January 2016 to August 2016...
March 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29540085/higher-levels-of-thyrotropin-in-pregnancy-and-adverse-pregnancy-outcomes
#17
Tatjana Barišić, Vjekoslav Mandić, Anja Vasilj, Dejan Tiric
OBJECTIVE: To determine the frequency of subclinical hypothyroidism in women with pathological pregnancies and the association between elevated thyroid-stimulating hormone (TSH) and pregnancy outcome. SUBJECTS AND METHODS: A cross-sectional prospective study investigated value of TSH and free thyroxine (FT4) in (1) pregnant women with hypertension (HTA) (N = 62) or preeclampsia (PE) (N = 50), (2) women with gestational diabetes mellitus (GDM) (N = 92) in pregnancy, and (3) women with normal pregnancies (control) (N = 201)...
March 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29535930/prevalence-of-hypothyroidism-in-term-pregnancies-in-north-india
#18
Bharti Kalra, Meenu Choudhary, Meenakshi Thakral, Sanjay Kalra
Background: Hypothyroidism is common in pregnancy. No study has determined the prevalence of hypothyroidism in term pregnancies in India. Aim: This study aims to determine the prevalence and correlates of hypothyroidism in women who delivered at a center in Karnal, Haryana, North India. Results: Indoor records of all women who had delivered at this centre from April 2016 to March 2017 were reviewed. The prevalence of hypothyroidism was 12...
January 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29535929/a-systematic-review-on-normative-values-of-trimester-specific-thyroid-function-tests-in-indian-women
#19
Subramanian Kannan, Shriraam Mahadevan, Alben Sigamani
Background: Small cross-sectional studies are published on the trimester-specific normal ranges of thyrotropin and thyroxine levels in Indian women from various parts of the country. Objective: We sought to review the published literature on thyroid function tests in normal pregnant Indian women to see if the pooled data from various studies can define normative data and hypothyroidism in pregnancy. Methods: We retrieved 56 studies from online databases with detailed search using multiple search terms...
January 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29527855/thyroid-disease-in-pregnancy-a-clinical-survey-among-endocrinologists-gynecologists-and-obstetricians-in-israel
#20
Ronit Koren, Yifat Wiener, Karen Or, Carlos A Benbassat, Shlomit Koren
OBJECTIVES: To study the current practices in the management of subclinical hypothyroidism (SCH) and thyroid nodules during pregnancy of obstetricians/gynecologists (OB/GYNs) and endocrinologists in Israel. METHODS: An electronic questionnaire was sent by email to all members of the Israeli Endocrine Society and the Israel Society of Obstetrics and Gynecology. Questionnaires included demographic data and clinical scenarios with questions regarding the screening and management of pregnant women with SCH, hypothyroxinemia, and a palpable thyroid nodule...
March 2018: Israel Medical Association Journal: IMAJ
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