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hypothyroidism in pregnancy

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https://www.readbyqxmd.com/read/28917612/thyroid-stimulating-hormone-anti-thyroid-antibodies-and-pregnancy-outcomes
#1
Torie C Plowden, Enrique F Schisterman, Lindsey A Sjaarda, Neil J Perkins, Robert Silver, Rose Radin, Keewan Kim, Noya Galai, Alan H DeCherney, Sunni L Mumford
BACKGROUND: Overt thyroid dysfunction has been associated with adverse obstetrical outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications. OBJECTIVE: To examine the association between pre-pregnancy anti-thyroid antibodies and subclinical hypothyroidism and preterm delivery (PTD), gestational diabetes (GDM), and preeclampsia. STUDY DESIGN: Secondary analysis of a prospective cohort of 18-40 year old women with 1-2 prior pregnancy losses (n=1193) participating in a multi-center randomized, placebo-controlled trial of low-dose aspirin...
September 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28913145/subclinical-hypothyroidism-is-it-important-in-intracytoplasmic-sperm-injection-cycles
#2
Eray Çalışkan, Rahime Nida Ergin, Deniz Can Öztekin, Bülent Kars, Seda Çakır, Kenan Sofuoğlu
OBJECTIVE: To compare intracytoplasmic sperm injection (ICSI) outcomes of women with subclinical hypothyroidism with those of euthyroid women. MATERIALS AND METHODS: A retrospective case-control study was conducted. Out of 2529 ICSI cycles evaluated, 41 women with hypothyroidism, 28 women with hyperthyroidism, and 128 women with subclinical hyperthyroidism were excluded, and 2336 cycles were analyzed. Women were identified as having subclinical hypothyroidism (case group, n=105) in the presence of a thyroid-stimulating hormone level >4...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28911144/randomized-trial-comparing-two-algorithms-for-levothyroxine-dose-adjustment-in-pregnant-women-with-primary-hypothyroidism
#3
Shannon D Sullivan, Erin Downs, Geanina Popoveniuc, Alexander Zeymo, Jacqueline Jonklaas, Kenneth D Burman
Context: Regulation of maternal thyroid hormones during pregnancy is crucial for optimal maternal and fetal outcomes. There are no specific guidelines addressing maternal levothyroxine (LT4) dose adjustments throughout pregnancy. Objective: To compare two LT4 dose-adjustment algorithms in hypothyroid pregnant women. Design: Thirty-three women on stable LT4 doses were recruited at <10 weeks gestation during 38 pregnancies and randomized to one of two dose-adjustment groups...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28904049/use-of-thyroid-stimulating-hormone-tests-for-identifying-primary-hypothyroidism-in-family-medicine-patients
#4
Elizabeth Birk-Urovitz, M Elisabeth Del Giudice, Christopher Meaney, Karan Grewal
OBJECTIVE: To assess the use of thyroid-stimulating hormone (TSH) tests for identifying primary hypothyroidism in 2 academic family medicine settings. DESIGN: Descriptive study involving a retrospective electronic chart review of family medicine patients who underwent TSH testing. SETTING: Two academic family practice sites: one site is within a tertiary hospital in Toronto, Ont, and the other is within a community hospital in Newmarket, Ont...
September 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28867693/mild-thyroid-peroxidase-deficiency-caused-by-tpo-mutations-with-residual-activity-correlation-between-clinical-phenotypes-and-enzymatic-activity
#5
Satoshi Narumi, Larry A Fox, Keisuke Fukudome, Zenichi Sakaguchi, Chiho Sugisawa, Kiyomi Abe, Kaori Kameyama, Tomonobu Hasegawa
Thyroid peroxidase (TPO) deficiency, caused by biallelic TPO mutations, is a well-established genetic form of congenital hypothyroidism (CH). More than 100 patients have been published, and the patients have been diagnosed mostly in the frame of newborn screening (NBS) programs. Correlation between clinical phenotypes and TPO activity remains unclear. Here, we report clinical and molecular findings of two unrelated TPO mutation-carrying mildly hypothyroid patients. The two patients were born at term after an uneventful pregnancy and delivery, and were NBS negative...
September 1, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28854714/routine-serum-thyroid-stimulating-hormone-testing-optimizing-pre-conception-health-or-generating-toxic-knowledge
#6
Abha Maheshwari, Priya Bhide, Jyotsna Pundir, Siladitya Bhattacharya
Monitoring subclinical hypothyroidism (SCH) in women is believed to be important in terms of preventing overt hypothyroidism and optimizing the health and cognitive development of their children. Current systematic reviews have suggested an association between maternal SCH and adverse obstetric and neonatal outcomes. However, initiating the administration of thyroxine during pregnancy has failed to demonstrate appreciable health benefits. Hence there are calls by professional endocrine societies for optimizing serum thyroid-stimulating hormone (TSH) levels pre-conception...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28814477/iodine-excess-exposure-during-pregnancy-and-lactation-impairs-maternal-thyroid-function-in-rats
#7
Caroline Serrano-Nascimento, Rafael Barrera Salgueiro, Kaio Fernando Vitzel, Thiago Pantaleão, Vânia Maria Corrêa da Costa, Maria Tereza Nunes
Adequate maternal iodine consumption during pregnancy and lactation guarantees normal thyroid hormones (TH) production, which is crucial to the development of the fetus. Indeed, iodine deficiency is clearly related to maternal hypothyroidism and deleterious effects in the fetal development. Conversely, the effects of iodine excess (IE) consumption on maternal thyroid function are still controversial. Therefore, this study aimed to investigate the impact of IE exposure during pregnancy and lactation periods on maternal hypothalamus-pituitary-thyroid axis...
October 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28813223/subclinical-hypothyroidism-or-hypothyroxinemia-in-pregnancy
#8
LETTER
Brian M Casey, Elizabeth A Thom
New England Journal of Medicine, Volume 377, Issue 7, Page 700-701, August 2017.
August 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28813222/subclinical-hypothyroidism-or-hypothyroxinemia-in-pregnancy
#9
LETTER
Laszlo Hegedüs, Thomas H Brix
No abstract text is available yet for this article.
August 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28807719/maternal-hypothyroidism-an-overview-of-current-experimental-models
#10
REVIEW
Mahboubeh Ghanbari, Asghar Ghasemi
Maternal hypothyroidism (MH) is the most common cause of transient congenital hypothyroidism. Different animal models are used for assessing developmental effects of MH in offspring. The severity and status of hypothyroidism in animal models must be a reflection of the actual conditions in humans. To obtain comparable results with different clinical conditions, which lead to MH in humans, several factors have been suggested for researchers to consider before designing the experimental models. Regarding development of fetal body systems during pregnancy, interference at different times provides different results and the appropriate time for induction of hypothyroidism should be selected based on accurate time of development of the system under assessment...
October 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28799288/neuroprotective-activity-of-cannabinoid-receptor-2-against-oxidative-stress-and-apoptosis-in-rat-pups-having-experimentally-induced-congenital-hypothyroidism
#11
Mehmet Eray Alcigir, Halef Okan Dogan, Sevil Atalay Vural, Fatma Meriç Yilmaz
In this study, it was aimed to show the cannabinoid receptor-2 (CB2) role, which is a part of neuroprotective endocannabinoidal system, against increasing nitric oxide synthetase (iNOS, eNOS) levels and the apoptotic activity (caspase-3, caspase-9 and DNA in situ fragmentation) within the postnatal critical period in pups of pregnant rats with artificially induced maternal thyroid hormone (TH) deficiency. Each of the 3 groups established comprised 1 male and 2 female rats, and they were coupled. Their pups were used...
August 11, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28758357/thyroid-medication-use-and-birth-defects-in-the-national-birth-defects-prevention-study
#12
Meredith M Howley, Sarah C Fisher, Alissa R Van Zutphen, Dorothy K Waller, Suzan L Carmichael, Marilyn L Browne
BACKGROUND: Thyroid disorders are common among reproductive-aged women, with hypothyroidism affecting 2 to 3% of pregnancies, and hyperthyroidism affecting an additional 0.1 to 1%. We examined associations between thyroid medications and individual birth defects using data from the National Birth Defects Prevention Study (NBDPS). METHODS: The NBDPS is a multisite, population-based, case-control study that included pregnancies with estimated delivery dates from 1997 to 2011...
July 31, 2017: Birth defects research
https://www.readbyqxmd.com/read/28755549/childhood-maltreatment-is-associated-with-increased-risk-of-subclinical-hypothyroidism-in-pregnancy
#13
Nora K Moog, Christine M Heim, Sonja Entringer, Norbert Kathmann, Pathik D Wadhwa, Claudia Buss
The critical importance of thyroid hormones for fetal development is well established. The developing fetus is dependent on the mother for adequate thyroid hormone supply, and maternal thyroid dysfunction in pregnancy may result in suboptimal fetal development. Because exposure to childhood maltreatment (CM) has been associated with thyroid dysfunction in the non-pregnant state, we sought to test the hypothesis that exposure to CM may represent a risk factor for the development of maternal hypothyroidism in pregnancy...
October 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28746798/thyroid-disease-symptoms-during-early-pregnancy-do-not-identify-women-with-thyroid-hypofunction-that-should-be-treated
#14
V J Pop, M A Broeren, W M Wiersinga, A Stagnaro-Green
OBJECTIVE: to evaluate whether women during early pregnancy with ''hypothyroidism'' symptoms are at risk for biochemical defined hypothyroidism. The 2017 guidelines of the American Thyroid Association (ATA) recommend case finding on the basis of symptoms to identify these women during pregnancy, while evidence is lacking. DESIGN: Construct validation of a thyroid hypofunction symptom checklist during first trimester of pregnancy comparing high scores with biochemical defined hypothyroidism...
July 26, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28729012/evidence-that-children-born-at-early-term-37-38-6-7-weeks-are-at-increased-risk-for-diabetes-and-obesity-related-disorders
#15
Dorit Paz Levy, Eyal Sheiner, Tamar Wainstock, Ruslan Sergienko, Daniella Landau, Asnat Walfisch
BACKGROUND: Prematurity is known to be associated with high rates of endocrine and metabolic complications in the offspring. Offspring born early term (37-38 6/7 weeks' gestation) were also shown to exhibit long-term morbidity resembling that of late preterm, in several health categories. OBJECTIVE: We aimed to determine whether early term delivery impacts on the long-term endocrine and metabolic health of the offspring. STUDY DESIGN: A population-based cohort analysis was performed, including all term singleton deliveries occurring from 1991 through 2013 at a single regional tertiary medical center...
July 18, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28726182/autoimmune-hypothyroidism-is-three-times-more-frequent-in-female-prolactinoma-patients-compared-to-healthy-women-data-from-a-cross-sectional-case-control-study
#16
Atanaska Elenkova, Iliana Аtanasova, Georgi Кirilov, Еmil Natchev, Ralitza Ivanova, Roussanka Кovatcheva, Silvia Vandeva, Dimitar Tcharaktchiev, Sabina Zacharieva
BACKGROUND: The potent immunomodulatory action of prolactin has been demonstrated in many experimental in vitro studies. In accordance with these data, our retrospective analyses revealed higher prevalence of autoimmune thyroid diseases in prolactinoma patients compared to general population. PURPOSE: A cross-sectional case-control study was carried out in a single tertiary referral centre. The main aim was to assess the frequency of newly diagnosed autoimmune thyroid diseases in female patients with prolactinomas...
July 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28716849/subclinical-hypothyroidism-in-pregnancy
#17
Siobhan Deshauer, Ahraaz Wyne
No abstract text is available yet for this article.
July 17, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28713431/an-unexpected-cause-of-bradycardia-in-a-patient-with-bacterial-meningitis
#18
Petros Ioannou, Magdalini Velegraki, Stella Soundoulounaki, Achilleas Gikas, Diamantis P Kofteridis
Sinus bradycardia which is a sinus rhythm with a resting heart rate of less than 60 bpm is caused by intrinsic cardiac disorders like sick sinus syndrome or inferior myocardial infarction, metabolic and environmental causes (such as hypothyroidism and electrolyte disorders), medications (such as beta-blockers and amiodarone), infection (such as myocarditis), increased intracranial pressure, and toxic exposure, while it can sometimes be a normal phenomenon, especially during sleep, in athletes, and during pregnancy...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28713331/thyroid-stimulating-hormone-receptor-antibodies-in-pregnancy-clinical-relevance
#19
REVIEW
Ines Bucci, Cesidio Giuliani, Giorgio Napolitano
Graves' disease is the most common cause of thyrotoxicosis in women of childbearing age. Approximately 1% of pregnant women been treated before, or are being treated during pregnancy for Graves' hyperthyroidism. In pregnancy, as in not pregnant state, thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAbs) are the pathogenetic hallmark of Graves' disease. TRAbs are heterogeneous for molecular and functional properties and are subdivided into activating (TSAbs), blocking (TBAbs), or neutral (N-TRAbs) depending on their effect on TSHR...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28704846/the-effect-of-treated-overt-hypothyroidism-on-outcomes-in-twin-pregnancies
#20
Jonathan Y Rosner, Nathan S Fox, Daniel Saltzman, Andrei Rebarber, Simi Gupta
No abstract text is available yet for this article.
July 13, 2017: American Journal of Perinatology
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