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Naringin AND Smad

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https://www.readbyqxmd.com/read/27174133/sodium-arsenite-induced-myocardial-bruise-in-rats-ameliorative-effect-of-naringin-via-tgf-%C3%AE-smad-and-nrf-ho-pathways
#1
Mohammad Adil, Amit D Kandhare, Pinaki Ghosh, Subhash L Bodhankar
BACKGROUND: Arsenic poisoning is a serious medical condition caused by consumption of contaminated food and water. Cardiovascular toxicity is one of the important risk factors associated with arsenic toxicity. AIM: To elucidate efficacy and possible mechanism of action of naringin in arsenic-induced cardiac toxicity in laboratory rats. MATERIALS AND METHODS: Arsenic toxicity was induced in Sprague-Dawley rats by sodium arsenite (5 mg/kg, p...
June 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/25894211/wound-healing-potential-of-naringin-ointment-formulation-via-regulating-the-expression-of-inflammatory-apoptotic-and-growth-mediators-in-experimental-rats
#2
Amit D Kandhare, Javed Alam, Mithun V K Patil, Akanksha Sinha, Subhash L Bodhankar
CONTEXT: Wound healing is a consequence of a complex process involving inflammatory, proliferative, and remodeling phases. Naringin, a flavanone glycoside, is associated with modulation of various oxido-inflammatory and growth factors. AIM: The aim of this study is to evaluate the wound-healing activity of naringin ointment formulation (NOF) on experimental wound models. MATERIALS AND METHODS: A soft paraffin-based cream containing 1, 2, and 4% (w/w) naringin was formulated and evaluated for physicochemical characters...
2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/24317428/immobilization-of-naringin-onto-chitosan-substrates-by-using-ozone-activation
#3
Chung Hsing Li, Jing Wei Wang, Ming Hua Ho, Jia Lin Shih, Sheng Wen Hsiao, Doan Van Hong Thien
Ozone oxidation can easily produce peroxides containing active free radicals that can be used for the surface modification of biomaterials. This process is highly efficient and nontoxic. In this research, naringin, an HMG-CoA reductase inhibitor that can promote bone formation, was immobilized onto a chitosan film using ozone activation. First, a chitosan film was treated by ozone to produce peroxides; these peroxides were then quantified and their amount was optimized by an iodide assay. For the in vitro delivery of naringin, a chitosan-naringin substrate was immersed in phosphate-buffered saline to quantify the released amount of naringin...
March 1, 2014: Colloids and Surfaces. B, Biointerfaces
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