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Naringenin AND Smad

Wei Wei, Fang Rao, Fangzhou Liu, Yumei Xue, Chunyu Deng, Zhaoyu Wang, Jiening Zhu, Hui Yang, Xin Li, Mengzhen Zhang, Yongheng Fu, Wensi Zhu, Zhixin Shan, Shulin Wu
Hypertension is a main risk factor for atrial fibrillation, but the direct effects of hydrostatic pressure on the atrial fibrosis are still unknown. The present study investigated whether hydrostatic pressure is responsible for atrial fibrosis, and addressed a potential role of the Smad pathway in this pathology. Biochemical assays were used to study regulation and expression of fibrotic factors in spontaneously hypertensive rats (SHRs) and Wistar rats, and in cardiac fibroblasts (CFs) cultured under standard (0 mmHg) and elevated (20, 40 mmHg) hydrostatic pressure...
June 2018: Journal of Cellular Physiology
Ning Yan, Li Wen, Rui Peng, Hongmei Li, Handeng Liu, Huimin Peng, Yan Sun, Tianhui Wu, Lei Chen, Qingrui Duan, Yixuan Sun, Qin Zhou, Lijiang Wei, Zheng Zhang
Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus (DM). However, the exact mechanism is not clearly understood. In this study, our results showed that 24 h urinary protein, kidney index, and glomerular area were decreased, while creatinine clearance ratio was increased in DN rats when the rats were treated with NAR 50 mg/d for 6 weeks. Mesangial cell (MMCs) proliferation was inhibited in the NAR group by 3,(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), and the cell cycle analysis showed that cells stayed in G2 phase in NAR group...
2016: Journal of Diabetes Research
Xiao-ming Meng, Yun Zhang, Xiao-Ru Huang, Gui-ling Ren, Jun Li, Hui Yao Lan
We recently showed that imbalance of TGF-β/Smad signaling with over-activation of Smad3 but lower levels of Smad7 is a central mechanism of tissue fibrosis. In the present study, we report here that inhibition of Smad3 with naringenin (NG) and upregulation of Smad7 with asiatic acid (AA) produced an additive effect on inhibition of renal fibrosis in a mouse model of obstructive nephropathy. We found that AA, a triterpene from Centella Asiatica, functioned as a Smad7 agonist and suppressed TGF-β/Smad3-mediated renal fibrosis by inducing Smad7...
November 10, 2015: Oncotarget
Xingjun Liu, Wei Wang, Han Hu, Ning Tang, Chunling Zhang, Wei Liang, Minwei Wang
PURPOSE: During the process of liver fibrogenesis, transforming growth factor-beta (TGF-beta) plays an essential role in modulating extracellular matrix (ECM) gene expression, and a growing body of evidence suggests that this is a Smad3-dependent process in the activated hepatic stellate cells (HSCs). Naringenin showed a significantly protective effect on experimental rat liver fibrosis, in our efforts to elucidate its antifibrosis molecular mechanisms and to find a novel target based on Smad3 signaling for challenging fibrosis diseases...
January 2006: Pharmaceutical Research
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