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okadaic acid

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https://www.readbyqxmd.com/read/29665236/a-tryptophan-prenyltransferase-with-broad-substrate-tolerance-from-bacillus-subtilis-subsp-natto
#1
Ikuro Abe, Tomotoshi Sugita, Masahiro Okada, Yu Nakashima, Tian Tian
Bacillus subtilis subsp. natto secrets the ComXnatto pheromone as a quorum sensing pheromone to produce poly-γ-glutamate for biofilm formation. The amino acid sequence of the pheromone is Lys-Trp-Pro-Pro-Ile-Glu, and the tryptophan residue is post-translationally modified with a farnesyl group to form a tricyclic scaffold. Unlike other Bacillus ComX pheromones, the tryptophan residue is distant from the C-terminal end of the precursor peptide ComXnatto. Here we report the functional analysis of ComQnatto, which catalyzes a unique farnesyl-transfer reaction...
April 17, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29660783/contribution-of-2-propenesulfenic-acid-to-the-antioxidant-activity-of-allicin
#2
Kensuke Seki, Junya Ishikawa, Youji Okada
We re-examined the antioxidative mechanism of allicin as a radical scavenger on the basis of the reactivity toward 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and peroxyl radicals. Initially, it was found that allicin decomposed more rapidly in n-hexane and chlorobenzene than in acetonitrile, ethanol, and ethanol/water solutions and decomposed into ajoene and vinyldithiins in these solvents. Furthermore, the decomposition of allicin and the following formations of ajoene and vinyldithiins from allicin were accelerated by the reaction of allicin with DPPH and peroxyl radicals...
April 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29656651/tio2-photocatalysis-in-aromatic-redox-tag-guided-intermolecular-formal-2-2-cycloadditions
#3
Yohei Okada, Naoya Maeta, Kaii Nakayama, Hidehiro Kamiya
Since the pioneering work by Macmillan, Yoon, and Stephenson, homogeneous photoredox catalysis has occupied a central place in new reaction development in the field of organic chemistry. While heterogeneous semiconductor photocatalysis has also been studied extensively, it has generally been recognized as a redox option in inorganic chemistry where such "photoca-talysis" is most often used to catalyze carbon-carbon bond cleavage, and not in organic chemistry where bond formation is usu-ally the focal point...
April 15, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29655730/nmr-and-gc-ms-based-metabolomic-characterization-of-sunki-an-unsalted-fermented-pickle-of-turnip-leaves
#4
Satoru Tomita, Toshihide Nakamura, Sanae Okada
This study revealed the compositional characteristics of sunki, a traditional, unsalted, lactic acid-fermented pickle produced using turnip leaf in Kiso district, Japan. Comprehensive compositional analysis by two metabolomic approaches based on NMR and solid-phase microextraction-GC/MS methods was used to determine its chemical composition by annotating 54 water-soluble and 62 volatile compounds. Principal component analysis showed that samples had different compositions, depending on the agricultural processing factory and production year...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29650854/-a-case-of-hyperammonemia-induced-by-chemotherapy-with-5-fluorouracil-for-metastatic-colon-cancer
#5
Shinji Tokuyama, Mutsumi Fukunaga, Ken Konishi, Shoko Honda, Ryohei Yukimoto, Aoi Okamoto, Akina Saito, Kazuyuki Okada, Hideo Ota, Shigekazu Yokoyama, Hirofumi Miki, Kenji Kobayashi
Systemic chemotherapy based on 5-fluorouracil(5-FU)is a standard treatment for unresectable or recurrent colon cancers. Here, we report a case of hyperammonemia induced by chemotherapy using 5-FU for metastatic colon cancer. An 84-yearold male patient with past histories of liver cirrhosis related to hepatitis C virus and renal dysfunction underwent an operation for the rectosigmoid colon cancer 8 years ago. Three years after that operation, a local recurrence of the colon cancer was diagnosed, and chemotherapy using sLV5FU2 was initiated...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29625581/evaluation-of-the-effects-of-ascorbic-acid-on-metabolism-of-human-mesenchymal-stem-cells
#6
Koichi Fujisawa, Kazusa Hara, Taro Takami, Sae Okada, Toshihiko Matsumoto, Naoki Yamamoto, Isao Sakaida
BACKGROUND: Mesenchymal stem cells (MSCs) are multipotent cells holding much promise for applications in regenerative medicine. However, with problems such as aging, increases in heteroploid cells, genomic instability, and reduced maintenance of stemness, more stable culturing methods and the production of MSCs with an improved therapeutic effect are desired. Ascorbic acid (AsA), which is a cofactor for a variety of enzymes and has an antioxidant effect, cannot be synthesized by certain animals, including humans...
April 6, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29623310/identification-of-pp1-gadd34-substrates-involved-in-the-unfolded-protein-response-using-k-bips-a-method-for-phosphatase-substrate-identification
#7
Pavithra M Dedigama-Arachchige, Nuwan P N Acharige, Mary Kay H Pflum
Phosphorylation is a key post-translational modification in cell signaling, which is regulated by the equilibrium activities of kinases and phosphatases. The biological significance of many phosphorylation events remains poorly characterized due to the scarcity of tools to discover phosphatases substrates. In prior work, we established kinase-catalyzed biotinylation where kinases accept the γ-modified ATP analog, ATP-biotin, to label phosphoproteins. Here, we developed a novel method to study substrates of phosphatases using kinase-catalyzed biotinylation termed K-BIPS (Kinase-catalyzed Biotinylation to Identify Phosphatase Substrates)...
April 6, 2018: Molecular omics
https://www.readbyqxmd.com/read/29619240/comparison-of-petinia-and-lc-ms-ms-for-determining-plasma-mycophenolic-acid-concentrations-in-japanese-lung-transplant-recipients
#8
Masafumi Kikuchi, Masaki Tanaka, Shinya Takasaki, Akiko Takahashi, Miki Akiba, Yasushi Matsuda, Masafumi Noda, Kanehiko Hisamichi, Hiroaki Yamaguchi, Yoshinori Okada, Nariyasu Mano
Background: Mycophenolic acid (MPA) treatment requires therapeutic drug monitoring to improve the outcome after organ transplantation. The aim of this study was to compare two methods, a particle enhanced turbidimetric inhibition immunoassay (PETINIA) and a reference liquid chromatography tandem mass spectrometry (LC-MS/MS) for determining plasma MPA concentrations from Japanese lung transplant recipients. Methods: Plasma MPA concentrations were determined from 20 Japanese lung transplant recipients using LC-MS/MS and the PETINIA on the Dimension Xpand Plus-HM analyzer...
2018: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29618699/triterpenic-acids-from-potentilla-parvifolia-fisch-and-their-protective-effects-against-okadaic-acid-induced-neurotoxicity-in-differentiated-sh-sy5y-cells
#9
Zhen-Zhen Yuan, You-Rui Suo, Xue-Yan Hao, Shu-Lin Wang, Gang Li, Hong-Lun Wang
Six triterpenic acids were separated and purified from the ethyl acetate extractive fraction of ethanol extracts of Potentilla parvifolia Fisch. using a variety of chromatographic methods. The neuroprotective effects of these triterpenoids were investigated in the present study, in which the okadaic acid induced neurotoxicity in human neuroblastoma SH-SY5Y cells were used as an Alzheimer's disease cell model in vitro. The cell model was established with all trans-retinoic acid (5 μmol/L, 4 days) and okadaic acid (40 nmol/L, 6 hours) treatments to induce tau phosphorylation and synaptic atrophy...
April 3, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29615641/maresin-1-suppresses-imiquimod-induced-skin-inflammation-by-regulating-il-23-receptor-expression
#10
Natsuko Saito-Sasaki, Yu Sawada, Emi Mashima, Takashi Yamaguchi, Shun Ohmori, Haruna Yoshioka, Sanehito Haruyama, Etsuko Okada, Motonobu Nakamura
The anti-inflammatory effect of omega 3 polyunsaturated fatty acids has been confirmed in various inflammatory disease models. Maresin-1 (MaR1) is a lipid mediator derived from the omega-3 fatty acid docosahexaenoic acid (DHA) that has displayed strong anti-inflammatory effects in various inflammatory disease models. However, the effect of topical MaR1 on cutaneous inflammation remains unclear. Therefore, we initially examined the anti-inflammatory effects of topical Maresin-1 using an imiquimod (IMQ)-induced psoriasis-like mouse model of inflammation...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29610558/effect-of-egualen-sodium-hydrate-on-small-intestinal-mucosal-damage-induced-by-low-dose-aspirin-a-prospective-randomized-clinical-trial
#11
Munetaka Iguchi, Kazuki Kakimoto, Takanori Kuramoto, Kei Nakazawa, Minori Kubota, Yuki Hirata, Kaori Fujiwara, Satoshi Harada, Taisuke Sakanaka, Kazuhiro Ota, Shoko Edogawa, Yuichi Kojima, Sadaharu Nouda, Toshihiko Okada, Ken Kawakami, Toshihisa Takeuchi, Takuya Inoue, Kazuhide Higuchi
Low-dose aspirin, which is widely used to reduce the risk of cardio- and cerebrovascular thrombosis, often induces gastroenteropathy by increasing the permeability of the mucosa. However, therapeutic strategies for patients with low-dose aspirin-induced small intestinal injury have not been determined. We evaluated the preventative effect of egualen sodium hydrate, a gastro-protective agent that suppresses indomethacin-induced small-intestinal damage in rats, against small-intestinal mucosal damage induced by low-dose aspirin in healthy adult male volunteers...
March 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29602499/thermal-acclimation-affects-growth-and-lipophilic-toxin-production-in-a-strain-of-cosmopolitan-harmful-alga-dinophysis-acuminata
#12
Leila Basti, Toshiyuki Suzuki, Hajime Uchida, Takashi Kamiyama, Satoshi Nagai
Species of the harmful algal bloom (HAB) genera Dinophysis are causative of one of the most widespread and expanding HAB events associated with the human intoxication, diarrheic shellfish poisoning (DSP). The effects of warming temperature on the physiology and toxinology of these mixotrophic species remain intractable due to their low biomass in nature and difficulties in establishing and maintaining them in culture. Hence, the present study investigated the influence of warming temperature, encompassing present and predicted climate scenarios, on growth and toxin production in a strain of the most cosmopolitan DSP-causative species, Dinophysis acuminata...
March 2018: Harmful Algae
https://www.readbyqxmd.com/read/29596798/neuroprotective-effect-of-paeoniflorin-on-okadaic-acid-induced-tau-hyperphosphorylation-via-calpain-akt-gsk-3%C3%AE-pathway-in-sh-sy5y-cells
#13
Xiao-Hui Ma, Wen-Jun Duan, You-Sheng Mo, Jun-Li Chen, Shi Li, Wei Zhao, Lei Yang, Sui-Qing Mi, Xin-Liang Mao, Hong Wang, Qi Wang
Abnormal phosphorylation of tau, one of the most common symptoms of dementia, has become increasingly important in the study of the etiology and development of Alzheimer's disease. Paeoniflorin, the main bioactive component of herbaceous peony, is a monoterpene glycoside, which has been reported to exert beneficial effects on neurodegenerative disease. However, the effect of paeoniflorin on tauopathies remains ambiguous. SH-SY5Y cells were treated with okadaic acid (OA) for 8 h to induce tau phosphorylation and no cell death was observed...
March 26, 2018: Brain Research
https://www.readbyqxmd.com/read/29587772/oxidative-stress-enhances-the-expression-of-il-33-in-human-airway-epithelial-cells
#14
Hiroyuki Aizawa, Akira Koarai, Yutaka Shishikura, Satoru Yanagisawa, Mutsuo Yamaya, Hisatoshi Sugiura, Tadahisa Numakura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Masafumi Noda, Yoshinori Okada, Masakazu Ichinose
BACKGROUND: Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, and its possible involvement in the pathophysiology of COPD and viral-induced exacerbations has been demonstrated. IL-33 has been shown to be increased in the airway epithelial cells from COPD patients, but the regulating mechanism of IL-33 expression in airway epithelial cells remains largely unknown. In the current study, we examined whether oxidative stress, which participates in the pathogenesis of COPD, affects the expression of IL-33 in airway epithelial cells and also evaluated the effect during viral infection...
March 27, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29556978/non-point-source-pollution-of-glyphosate-and-ampa-in-a-rural-basin-from-the-southeast-pampas-argentina
#15
Elena Okada, Débora Pérez, Eduardo De Gerónimo, Virginia Aparicio, Héctor Massone, José Luis Costa
We measured the occurrence and seasonal variations of glyphosate and its metabolite, aminomethylphosphonic acid (AMPA), in different environmental compartments within the limits of an agricultural basin. This topic is of high relevance since glyphosate is the most applied pesticide in agricultural systems worldwide. We were able to quantify the seasonal variations of glyphosate that result mainly from endo-drift inputs, that is, from direct spraying either onto genetically modified (GM) crops (i.e., soybean and maize) or onto weeds in no-till practices...
March 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29551748/transdermal-anti-nuclear-kappab-sirna-therapy-for-atopic-dermatitis-using-a-combination-of-two-kinds-of-functional-oligopeptide
#16
Hisako Ibaraki, Takanori Kanazawa, Yuuki Takashima, Hiroaki Okada, Yasuo Seta
Nucleic acid-based targeting of nuclear factor kappaB (NF-κB) is gaining attention as a treatment option for skin diseases like atopic dermatitis (AD). Transdermal administration improves patient quality of life because of non-invasive; however, siRNA delivery into the skin can be challenging owing to the barrier of tight junctions in the granular layer. Therefore, we aimed to develop a delivery system of siRNA for topical skin application using functional peptides. We previously reported that combined treatment with a cytoplasm-responsive stearylated-arginine-rich peptide (STR-CH2 R4 H2 C) and a tight junction opening peptide (AT1002) showed high siRNA permeability in the skin of AD-induced and normal mice...
March 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29537926/changes-in-potassium-channel-modulation-may-underlie-afterhyperpolarization-plasticity-in-oxytocin-neurons-during-late-pregnancy
#17
Lie Wang, Giri Kumar Chandaka, Robert C Foehring, Joseph C Callaway, William E Armstrong
Oxytocin (OT) neurons exhibit larger afterhyperpolarizations (AHPs) following spike trains during pregnancy and lactation, when these neurons burst and release more OT. Calcium-dependent AHPs mediated by SK channels show this plasticity, and are reduced when the channel is phosphorylated by casein kinase 2 (CK2), and increased when dephosphorylated by protein phosphatase 2A (PP2A), by altering Ca2+ sensitivity. We compared AHP currents in supraoptic OT neurons after CK2 inhibition with 4,5,6,7-tetrabromobenzotriazole (TBB), or PP1-PP2A inhibition with okadaic acid (OA) focusing on the peak current at 100 ms representing the SK-mediated, medium AHP (ImAHP )...
March 14, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29530069/inhibition-of-creb-binding-protein-beta-catenin-signaling-down-regulates-cd133-expression-and-activates-pp2a-pten-signaling-in-tumor-initiating-liver-cancer-cells
#18
Yuanyuan Tang, Joshua Berlind, Nirmala Mavila
BACKGROUND: The WNT-beta-catenin pathway is known to regulate cellular homeostasis during development and tissue regeneration. Activation of WNT signaling increases the stability of cytoplasmic beta-catenin and enhances its nuclear translocation. Nuclear beta-catenin function is regulated by transcriptional co-factors such as CREB binding protein (CBP) and p300. Hyper-activated WNT-beta-catenin signaling is associated with many cancers. However, its role in inducing stemness to liver cancer cells, its autoregulation and how it regulates tumor suppressor pathways are not well understood...
March 12, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29511968/amphetamine-neurotoxicity-in-pc12-cells-through-the-pp2a-akt-gsk3%C3%AE-pathway
#19
Wenji He, Xinyu Yan, Sanqiang Pan
Amphetamine (AMPH) abuse can influence neuropsychiatric disorders and cell apoptosis by interfering with the protein kinase B/ glycogen synthase kinase 3 beta (AKT/GSK3β) pathway. However, the mechanisms underlying this regulation are poorly understood. Using PC12 cells, we found that AMPH inhibited AKT and GSK-3β phosphorylation levels and increased total GSK-3β levels. Furthermore, AMPH caused an increase in the activity of protein phosphatase 2 (PP2A), a signaling protein upstream of AKT, which in turn inhibited phosphorylated AKT levels...
March 6, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29509999/seed-specific-rnai-in-safflower-generates-a-superhigh-oleic-oil-with-extended-oxidative-stability
#20
Craig C Wood, Shoko Okada, Matthew C Taylor, Amratha Menon, Anu Mathew, Darren Cullerne, Stuart J Stephen, Robert S Allen, Xue-Rong Zhou, Qing Liu, John G Oakeshott, Surinder P Singh, Allan G Green
Vegetable oils extracted from oilseeds are an important component of foods, but are also used in a range of high value oleochemical applications. Despite being biodegradable, non-toxic and renewable current plant oils suffer from the presence of residual polyunsaturated fatty acids that are prone to free radical formation that limit their oxidative stability, and consequently shelf-life and functionality. Many decades of plant breeding have been successful in raising the oleic content to ~90%, but has come at the expense of overall field performance, including poor yields...
March 6, 2018: Plant Biotechnology Journal
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