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https://www.readbyqxmd.com/read/27904647/prevalence-of-latent-tuberculosis-infection-in-healthcare-workers-at-a-hospital-in-naples-italy-a-low-incidence-country
#1
Monica Lamberti, Mariarosaria Muoio, Antonio Arnese, Sharon Borrelli, Teresa Di Lorenzo, Elpidio Maria Garzillo, Giuseppe Signoriello, Stefania De Pascalis, Nicola Coppola, Albert Nienhaus
BACKGROUND: Healthcare workers (HCWs) are at higher risk than the general population of contracting tuberculosis (TB). Moreover, although subjects with latent TB infection (LTBI) are asymptomatic and are not infectious, they may eventually develop active disease. Thus, a fundamental tool of TB control programs for HCWs is the screening and treatment of LTBI. METHODS: From January 2014 to January 2015, hospital personnel at Azienda Ospedaliera Universitaria, Naples, Italy, were screened for TB...
2016: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/27888495/an-unusual-presentation-of-intraocular-tuberculosis-in-a-monocular-patient-clinicopathological-correlation
#2
Kanika Aggarwal, Aniruddha Agarwal, Shobha Sehgal, Suryaprakash Sharma, Nirbhai Singh, Kusum Sharma, Ramanuj Samanta, Alessandro Invernizzi, Aman Sharma, Vishali Gupta
BACKGROUND: Lack of uniform diagnostic criteria often poses a challenge in the diagnosis and management of tubercular uveitis. The index case describes an unusual presentation of tubercular panuveitis initially misdiagnosed as sympathetic ophthalmia, where the appropriate diagnosis was made using various imaging and laboratory investigations. RESULTS: A 52-year-old Indian woman underwent multimodal imaging, extensive clinical and laboratory work-up, and analysis of microbiological and histopathological specimens...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27887611/the-performance-of-interferon-gamma-release-assay-in-nontuberculous-mycobacterial-diseases-a-retrospective-study-in-china
#3
Mao-Shui Wang, Jun-Li Wang, Xin-Feng Wang
BACKGROUND: The interferon-gamma release assay (IGRA) is more specific than the tuberculin skin test to discriminate between tuberculosis (TB) and nontuberculous mycobacterial (NTM) diseases. Here we performed a retrospective study to evaluate the performance of the T-SPOT.TB in patients with NTM diseases. METHODS: Between March, 2013 and Nov, 2015, a total of 58 patients with NTM diseases had a T-SPOT.TB performed were enrolled, 30 patients had definite NTM diseases, 28 had probable diseases...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27882115/retrospective-analysis-of-seven-breast-tuberculosis-cases
#4
Beyhan Çakar, Aydin Çiledağ
The present study aimed to evaluate the demographic data, diagnostic methods, therapeutic regimens and duration of therapy in 7 breast tuberculosis (BTB) cases. The data of BTB cases treated between January 2006 and December 2013 were retrospectively evaluated, with a total of 648 tuberculosis (TB) cases recorded during the 8-year period. Among these cases, 296 patients (50%) suffered from pulmonary TB, 278 (43%) from non-pulmonary TB and 45 (7%) from PTB plus NPTB. In total, 7 BTB were diagnosed, which constituted 1...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27863556/oral-vaccination-of-cattle-with-heat-inactivated-mycobacterium-bovis-does-not-compromise-bovine-tb-diagnostic-tests
#5
Gareth J Jones, Sabine Steinbach, Iker A Sevilla, Joseba M Garrido, Ramon Juste, H Martin Vordermeier
In this study we investigated whether oral uptake of a heat inactivated M. bovis wildlife vaccine by domestic cattle induced systemic immune responses that compromised the use of tuberculin or defined antigens in diagnostic tests for bovine TB. Positive skin test and blood-based IFN-γ release assay (IGRA) results were observed in all calves vaccinated via the parenteral route (i.e. intramuscular). In contrast, no positive responses to tuberculin or defined antigens were observed in either the skin test or IGRA test when performed in calves vaccinated via the oral route...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27855476/-tuberculosis-contact-investigation-eight-years-of-experience-with-the-quantiferon-tb%C3%A2-gold-in-tube-in-lower-saxony-germany
#6
M Scharlach, K Brakensiek
Since the beginning of the 21(st) century, beside tuberculin skin tests (TST) and chest X-rays, interferon-gamma release assays (IGRA) have become available for diagnosing latent tuberculosis infection. In 2006, the Governmental Institute of Public Health of Lower Saxony (NLGA) established the IGRA in its laboratory, using the QuantiFERON-TB(®)Gold In-Tube (QFT). A cohort of 19 309 contact persons who were investigated during contact tracing by local public health departments (LPHD) was analyzed. Within 3 years, 75% of LPHDs in Lower Saxony established the QFT for tuberculosis contact tracing...
November 17, 2016: Das Gesundheitswesen
https://www.readbyqxmd.com/read/27853753/elevated-circulating-concentrations-of-interferon-gamma-in-latent-tuberculosis-infection
#7
Moises A Huaman, George S Deepe, Carl J Fichtenbaum
BACKGROUND: Latent tuberculosis infection (LTBI) has been associated with increased immune activation. We assessed circulating concentrations of interferon-gamma in persons with LTBI. METHODS: We used the 2011-2012 National Health Nutritional Examination Survey (NHANES) to identify adults with and without LTBI by QuantiFERON(®)-TB Gold In-Tube (QFT) results. Non-LTBI persons were 1:1 age-, gender-, and race-matched to LTBI persons using propensity scores. We compared the plasma concentrations of interferon-gamma measured from the unstimulated, negative control QFT tube between LTBI and non-LTBI persons...
October 2016: Pathogens & Immunity
https://www.readbyqxmd.com/read/27852671/highly-multiplexed-proteomic-analysis-of-quantiferon-supernatants-to-identify-biomarkers-of-latent-tuberculosis-infection
#8
Mary Ann De Groote, Michael Higgins, Thomas Hraha, Kirsten Wall, Michael L Wilson, David G Sterling, Nebojsa Janjic, Randall Reves, Urs A Ochsner, Robert Belknap
The tests for diagnosing latent tuberculosis infection (LTBI) are limited by poor predictive value for identifying people at highest risk for progression to active TB, and have varying sensitivity and specificity in different populations. The identification of a more robust signature for LTBI is important for TB prevention and elimination. A pilot study was conducted with samples from immigrants to the U.S. that were screened for LTBI by the three commercially approved tests: Tuberculin Skin Test (TST), QuantiFERON-TB Gold In-Tube (QFT-GIT), and T-SPOT...
November 16, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27849401/looking-for-ocular-tuberculosis-prevalence-and-clinical-manifestations-of-patients-with-uveitis-and-positive-quantiferon-%C3%A2-tb-gold-test
#9
Kessara Pathanapitoon, Paradee Kunavisarut, Wasna Sirirungsi, Aniki Rothova
PURPOSE: To report on the prevalence of ocular TB and positive QuantiFERON(®)-TB Gold (QFT-G) test in uveitis patients and describe their clinical manifestations. METHODS: We performed a prospective study of 108 new human immunodeficiency virus-negative uveitis patients. All patients underwent a tailored screening protocol for uveitis and received QFT-G test and tuberculin skin tests (TST). RESULTS: QFT-G test was positive in 39/108 (36%) of patients, while TST ≥15 mm was positive in 16/108 (15%) patients...
November 16, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27843013/-tuberculosis-among-chronic-hemodialysis-patients-in-togo-report-of-10%C3%A2-cases
#10
Mawufemo Yawovi Tsevi, Akomola Kossi Sabi, Laté Mawuli Lawson-Ananissoh, Befa Noto-Kadou-Kaza, Eyram Yoan Amekoudi
GOALS: To determine the frequency of tuberculosis among hemodialysis patients in Togo, specify its different localizations and identify its diagnostic and therapeutic difficulties. PATIENTS AND METHODS: This was a retrospective study over a period of 5 years (2010-2015). It includes the records of periodic hemodialysis patients in the Nephrology Department of the Sylvanus-Olympio University Teaching Hospital in Lomé. The diagnosis of tuberculosis was selected on the basis of clinical and laboratory data...
November 11, 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/27833091/divergent-macrophage-responses-to-mycobacterium-bovis-among-naturally-exposed-uninfected-and-infected-cattle
#11
Omar A Alcaráz-López, Cindy García-Gil, Claudia Morales-Martínez, Gonzalo López-Rincón, Ciro Estrada-Chávez, José A Gutiérrez-Pabello, Hugo Esquivel-Solís
Mycobacterium bovis, the causative agent of bovine tuberculosis (BTB), is a successful pathogen that remains an important global threat to livestock. Cattle naturally exposed to M. bovis normally become reactive to the M. bovis-purified protein derivative (PPD; tuberculin) skin test; however, some individuals remain negative, suggesting they may be resistant to infection. To better understand host innate resistance to infection, 26 cattle from herds with a long history of high tuberculosis prevalence were included in this study...
November 11, 2016: Immunology and Cell Biology
https://www.readbyqxmd.com/read/27826286/transcriptomic-biomarkers-for-tuberculosis-evaluation-of-dock9-epha4-and-npc2-mrna-expression-in-peripheral-blood
#12
Leonardo S de Araujo, Lea A I Vaas, Marcelo Ribeiro-Alves, Robert Geffers, Fernanda C Q Mello, Alexandre S de Almeida, Adriana da S R Moreira, Afrânio L Kritski, José R Lapa E Silva, Milton O Moraes, Frank Pessler, Maria H F Saad
Lately, much effort has been made to find mRNA biomarkers for tuberculosis (TB) disease/infection with microarray-based approaches. In a pilot investigation, through RNA sequencing technology, we observed a prominent modulation of DOCK9, EPHA4, and NPC2 mRNA abundance in the blood of TB patients. To corroborate these findings, independent validations were performed in cohorts from different areas. Gene expression levels in blood were evaluated by quantitative real-time PCR (Brazil, n = 129) or reanalysis of public microarray data (UK: n = 96; South Africa: n = 51; Germany: n = 26; and UK/France: n = 63)...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27824599/progression-to-tuberculosis-disease-increases-with-multiple-exposures
#13
Robyn S Lee, Jean-François Proulx, Dick Menzies, Marcel A Behr
During a single year, a Canadian village had 34 individuals with microbiologically confirmed tuberculosis (TB) among 169 people with a new infection (20%). A contact investigation revealed multiple exposures for each person. We investigated whether the intensity of exposure might contribute to this extraordinary risk of disease.We carried out a case-control study using a public health database. Among those with a new infection, 34 had culture-confirmed TB (cases) and 118 did not progress to disease (controls)...
December 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27822960/limited-usefulness-of-the-interferon-gamma-release-assay-in-patients-with-hiv-infections-and-negative-tuberculin-skin-test-results-in-a-country-with-an-intermediate-tuberculosis-burden
#14
Min Jae Kim, Eun Young Nam, Kyoung Un Park, Pyeong Gyun Choe, Wan Beom Park, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim, Myoung-Don Oh, Nam Joong Kim
No abstract text is available yet for this article.
November 8, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27817127/the-conversion-rate-of-tuberculosis-screening-tests-during-biological-therapies-in-patients-with-rheumatoid-arthritis
#15
Giovanna Cuomo, Virginia D'Abrsca, Daniela Iacono, Ilenia Pantano
Screening for active tuberculosis (TB) and latent TB infection (LTBI) is mandatory to the initiation of biological therapy in patients with rheumatic diseases. To determine the prevalence of LTBI in patients with rheumatoid arthritis before treatment with biological therapy (anti-TNF, abatacept, and tocilizumab) and the rate of TB conversion during treatment in rheumatoid arthritis (RA) patients, we evaluated the file of 275 patients with RA treated with biological agents. We considered patients with negative baseline TB screening (tuberculin skin test (TST); quantiferon TB gold in tube (QFT-GIT); chest x-ray) and with rescreening for a TB assay every year...
November 5, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27812634/prevalence-of-latent-mycobacterium-tuberculosis-infection-in-prisoners
#16
Pedro Daibert de Navarro, Isabela Neves de Almeida, Afrânio Lineu Kritski, Maria das Graças Ceccato, Mônica Maria Delgado Maciel, Wânia da Silva Carvalho, Silvana Spindola de Miranda
Objective: To determine the prevalence of and the factors associated with latent Mycobacterium tuberculosis infection (LTBI) in prisoners in the state of Minas Gerais, Brazil. Methods: This was a cross-sectional cohort study conducted in two prisons in Minas Gerais. Tuberculin skin tests were performed in the individuals who agreed to participate in the study. Results: A total of 1,120 individuals were selected for inclusion in this study...
September 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27809952/tuberculosis-and-transplantation
#17
José M Aguado, José Tiago Silva, Palash Samanta, Nina Singh
Mycobacterium tuberculosis is a major opportunistic pathogen in transplant recipients. Compared to that in the general population, the frequency of tuberculosis (TB) is 10 to 40 times higher in hematopoietic stem cell transplant (HSCT) recipients and 20 to 74 times higher in solid-organ transplant (SOT) recipients. Transplant recipients with TB are also more likely to develop disseminated disease, have longer time to definitive diagnosis, require more invasive diagnostic procedures, and experience greater anti-TB treatment-related toxicity than the general population...
November 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27809805/detection-of-latent-tuberculosis-infection-among-migrant-farmworkers-along-the-us-mexico-border
#18
E Oren, M H Fiero, E Barrett, B Anderson, M Nuῆez, F Gonzalez-Salazar
BACKGROUND: Migrant farmworkers are among the highest-risk populations for latent TB infection (LTBI) in the United States with numerous barriers to healthcare access and increased vulnerability to infectious diseases. LTBI is usually diagnosed on the border using the tuberculin skin test (TST). QuantiFERON-TB Gold In-Tube (QFT-GIT) also measures immune response against specific Mycobacterium tuberculosis antigens. The objective of this study is to assess the comparability of TST and QFT-GIT to detect LTBI among migrant farmworkers on the border, as well as to examine the effects of various demographic and clinical factors on test positivity...
November 3, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27797813/hoarse-voice-a-rare-presentation-of-tuberculosis-lymphadenitis
#19
Laurie Rigueros Springford, Krishan Ramdoo, Dilip Nair, Ali Taghi
A man aged 37 years from Indian descent presented to an inner city London hospital with hoarseness of voice, fatigue, night sweats and a 2 kg weight loss. Laryngoscopy demonstrated a left vocal fold palsy. Extensive investigations were undertaken with disseminated malignancy being primarily investigated. CT/MRI scanning showed non-specific necrotic mediastinal lymph nodes. Tuberculin skin testing, cytology and PCR were eventually undergone. Tests yielded results consistent with tuberculosis (TB) infection and the patient was started on standard TB treatment protocol, with excellent results...
October 24, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27794078/clemens-von-pirquet-a-remarkable-life-and-career
#20
REVIEW
Stanford T Shulman
From 1908 to 1929, Clemens von Pirquet was one of the world's most acclaimed pediatricians. Von Pirquet (1874-1929) trained at Vienna's Universitäts Kinderklinic under Theodor Escherich, the first Pediatric Infectious Diseases physician [ 1], and became the first Professor and Chair of Pediatrics at Johns Hopkins in 1909. He then succeeded his mentor Escherich as Professor and Chair of Pediatrics in Vienna, the most prestigious European pediatric position, when Escherich died unexpectedly in 1911. He held that position in Vienna until his shocking double suicide at age 54 with his wife in 1929...
October 28, 2016: Journal of the Pediatric Infectious Diseases Society
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