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https://www.readbyqxmd.com/read/29787713/interferon-gamma-release-assay-performance-in-northeastern-brazil-influence-of-the-ifng-874-a-t-polymorphism
#1
Valdirene Leão Carneiro, Maria Teresita Bendicho, Rosalina Guedes Santos, Marilda Casela, Eduardo M Netto, Scarlet Torres Moraes Mota, Iza Cristina Araújo Pina, Roberto Meyer Nascimento, Songeli Menezes Freire, Theolis Barbosa
INTRODUCTION: Latent tuberculosis infection diagnosis based on the release of interferon-gamma in cultures of peripheral blood cells stimulated with Mycobacterium tuberculosis antigens has replaced the tuberculin skin test in many countries with low tuberculosis prevalence. The IFN-γ production can be influenced by genetic polymorphisms, of which the IFNG+874 (rs62559044) locus is the most studied. We investigated the possible influence of the IFNG+874 A/T polymorphism on interferon-gamma test performance...
May 19, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29778630/bcg-vaccination-protects-against-infection-with-mycobacterium-tuberculosis-ascertained-by-tuberculin-skin-testing
#2
Pelzer Pt, Mutayoba B, Cobelens Fgj
OBJECTIVES: There is conflicting evidence as to whether Bacillus Calmette-Guérin (BCG) vaccination offers protection against Mycobacterium tuberculosis infection ascertained by a positive tuberculin skin test (TST). We investigated the association between BCG vaccination status and TST results in a set of surveys at increasing TST cut-off values to take cross-reactions to BCG vaccination into account. METHODS: Secondary analysis of data from three consecutive tuberculin surveys done among schoolchildren in Tanzania between 1990 and 2002...
May 17, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29775913/mobile-phone-based-evaluation-of-latent-tuberculosis-infection-proof-of-concept-for-an-integrated-image-capture-and-analysis-system
#3
Safa Naraghi, Tinashe Mutsvangwa, René Goliath, Molebogeng X Rangaka, Tania S Douglas
BACKGROUND: The tuberculin skin test is the most widely used method for detecting latent tuberculosis infection in adults and active tuberculosis in children. We present the development of a mobile-phone based screening tool for measuring the tuberculin skin test induration. METHOD: The tool makes use of a mobile application developed on the Android platform to capture images of an induration, and photogrammetric reconstruction using Agisoft PhotoScan to reconstruct the induration in 3D, followed by 3D measurement of the induration with the aid of functions from the Python programming language...
May 8, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29769160/cross-border-outbreak-of-extensively-drug-resistant-tuberculosis-linked-to-a-university-in-romania
#4
O Popovici, Ph Monk, D Chemtob, D Chiotan, P J Freidlin, R Groenheit, M Haanperä, D Homorodean, M Mansjö, E Robinson, E Rorman, G Smith, H Soini, M J Van Der Werf
Extensively drug-resistant (XDR) tuberculosis (TB) poses a threat to public health due to its complicated, expensive and often unsuccessful treatment. A cluster of three XDR TB cases was detected among foreign medical students of a Romanian university. The contact investigations included tuberculin skin testing or interferon gamma release assay, chest X-ray, sputum smear microscopy, culture, drug susceptibility testing, genotyping and whole-genome sequencing (WGS), and were addressed to students, personnel of the university, family members or other close contacts of the cases...
May 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29757355/a-prospective-study-to-monitor-for-tuberculosis-during-anti-tumour-necrosis-factor-therapy-in-patients-with-inflammatory-bowel-disease-and-immune-mediated-inflammatory-diseases
#5
Choon Kin Lee, Sunny H Wong, Grace Lui, Whitney Tang, Lai San Tam, Margaret Ip, Esther Hung, Minhu Chen, Justin C Wu, Siew C Ng
Background: Biologic therapies have revolutionised the treatment of immune- mediated diseases including inflammatory bowel disease (IBD) and rheumatological disorders. However, biologic treatments are associated with an increased risk of reactivation of latent tuberculosis. Data of regular monitoring for latent tuberculosis infection (LTBI) during biologic treatment are lacking. Methods: Consecutive patients eligible for biologic therapies were screened for LTBI and prospectively followed-up for 3 years...
May 11, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29755013/screening-for-latent-tuberculosis-infection-in-patients-with-inflammatory-bowel-disease-can-interferon-gamma-release-assays-replace-the-tuberculin-skin-test
#6
José Luis Cabriada, Rafael Ruiz-Zorrilla, Jesús Barrio, Ramón Atienza, Alain Huerta, Iago Rodríguez-Lago, Antonio Bernal, César Herrero
BACKGROUND/AIMS: Screening for latent tuberculosis infection is mandatory before starting anti-tumor necrosis factor therapy. New assays based on interferon-γ (IFN-γ) release have recently become available and may be more accurate. The aim of this study was to compare QuantiFERON-TB and tuberculin skin test in screening for latent infection in patients with inflammatory bowel disease. MATERIALS AND METHODS: We prospectively screened 138 patients with inflammatory bowel disease for latent tuberculosis infection with chest X-ray, tuberculin skin test, and a third-generation QuantiFERON-TB test...
May 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29751780/quantiferon-tb-gold-in-tube-test-for-the-diagnosis-of-active-and-latent-tuberculosis-in-selected-health-facilities-of-addis-ababa-ethiopia
#7
Selam Niguse, Kassu Desta, Gebremdihin Gebremichael, Atsebeha Gebrezgeaxier, Mulluwork Getahun, Desta Kassa
OBJECTIVE: To determine the performance of QuantiFERON-TB IN-Gold for the diagnosis active tuberculosis and latent tuberculosis. RESULTS: A total of 213 participants (136 tuberculosis suspects, 66 latently infected) were enrolled. Of 213, 21 (15.4%) of the tuberculosis suspects and 3 (4.5%) of the latent tuberculosis groups were human immunodeficiency virus infected. The sensitivity, specificity, positive and negative predictive value of QuantiFERON-TB IN-Gold for the diagnosis of active tuberculosis was 70...
May 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29735171/high-rates-of-tuberculin-skin-test-positivity-due-to-methotrexate-therapy-false-positive-results
#8
Miguel Arias-Guillén, Marta M Sánchez Menéndez, Mercedes Alperi, Sabino Riestra-Menéndez, María Teresa González Budiño, Marta María García-Clemente, Susana Martínez-González, Ana Isabel Enríquez, Rebeca Alonso-Arias, Juan José Palacios Gutiérrez, Miguel Santibáñez, Pablo Coto-Segura, Pablo Martínez Camblor, Lucía García-Alfonso, Isla Morante, Patricio Escalante
RATIONALE: The tuberculin skin test (TST) and interferon γ release assays (IGRAs) are commonly used for latent tuberculosis infection (LTBI) screening. Unexpectedly high TST positivity rates have been reported in patients with rheumatic diseases, and methotrexate is frequently used in this population. We hypothesized that methotrexate use could be associated with false-positive TST results. OBJECTIVES: To investigate whether treatment with methotrexate and other factors are associated with false-positive TST results in patients with rheumatic diseases...
March 29, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29731933/latent-tuberculosis-infection-diagnosis-and-treatment
#9
Biljana Ilievska-Poposka, Marija Metodieva, Maja Zakoska, Cveta Vragoterova, Dejan Trajkov
INTRODUCTION: Latent tuberculosis infection (LTBI) is defined as a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens without evidence of clinically manifested active tuberculosis (TB). Diagnosis and treatment for LTBI are important for TB, especially in high-risk populations. Tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used to diagnose LTBI. AIM: The study aims to present the first results with IGRA test compared with TST in the screening of LTBI and the treatment results in the cases with LTBI in Macedonia...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29728429/interferon-%C3%AE-release-assay-performance-for-tuberculosis-in-childhood
#10
Alexander W Kay, Shamim M Islam, Kristen Wendorf, Janice Westenhouse, Pennan M Barry
BACKGROUND: Interferon-γ release assays (IGRAs) are important adjunctive tests for diagnosing tuberculosis (TB) disease in children. METHODS: We analyzed California TB registry data for patients ≤18 years with laboratory-confirmed TB disease during 2010-2015 to identify case characteristics associated with test selection and performance and measure IGRA sensitivity. RESULTS: In total, 778 cases of TB were reported; 360 were laboratory confirmed...
May 4, 2018: Pediatrics
https://www.readbyqxmd.com/read/29721337/influence-of-seasonality-and-circulating-cytokines-on-serial-quantiferon-discordances
#11
Marsha L Griffin, Saroochi Agarwal, Melissa Zhu Murphy, Larry D Teeter, Edward A Graviss
Objectives. An 18-month prospective study serially tested healthcare workers (HCWs) for tuberculosis infection (TBI) and reported discordant QuantiFERON Gold In-Tube® (QFT) results in some participants. The purpose of the current study was to investigate whether the interferon-gamma (IFN- γ ) measured by QFT in discordant individuals could be influenced by other circulating cytokines that vary seasonally at the time of phlebotomy. Methods. The CDC funded TBESC Task Order 18 (TO18) project to assess the use of Interferon Gamma Release Assays (IGRAs), T-SPOT...
2018: Tuberculosis Research and Treatment
https://www.readbyqxmd.com/read/29720095/addressing-knowledge-gaps-and-prevention-for-tuberculosis-infected-indian-adults-a-vital-part-of-elimination
#12
Andrea DeLuca, Gauri Dhumal, Mandar Paradkar, Nishi Suryavanshi, Vidya Mave, Rewa Kohli, Shri Vijay Bala Yogendra Shivakumar, Vidula Hulyolkar, Archana Gaikwad, Ashwini Nangude, Geeta Pardeshi, Dileep Kadam, Amita Gupta
BACKGROUND: India plans to eliminate tuberculosis (TB) by 2025, and has identified screening and prevention as key activities. Household contacts (HHCs) of index TB cases are a high-risk population that would benefit from rapid implementation of these strategies. However, best practices for TB prevention and knowledge gaps among HHCs have not been studied. We evaluated TB knowledge and understanding of prevention among tuberculin skin-test (TST) positive HHCs. While extensive information is available in other high-burden settings regarding TB knowledge gaps, identifying how Indian adult contacts view their transmission risk and prevention options may inform novel screening algorithms and education efforts that will be part of the new elimination plan...
May 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29718223/outcomes-of-treatment-for-latent-tuberculosis-infection-in-patients-with-inflammatory-bowel-disease-receiving-biologic-therapy
#13
Guilherme P Ramos, Gregory Stroh, Badr Al-Bawardy, William A Faubion, Konstantinos A Papadakis, Patricio Escalante
Background: Treatment for latent tuberculosis infection (LTBI) is of particular concern in patients with inflammatory bowel disease (IBD) initiating biologic therapies to prevent tuberculosis (TB) reactivation. This study aimed to evaluate the effectiveness of LTBI treatment in IBD patients receiving biologic therapy. Methods: There was a retrospective review of all IBD patients diagnosed with LTBI following a tuberculin skin test (TST) and/or interferon gamma release assay (IGRA) and who received biologic therapy between 2002 and 2016...
April 26, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29717989/-screening-for-tuberculosis-before-tnf%C3%AE-treatment-in-routine-rheumatic-care-in-iceland-result-from-the-nationwide-icebio-registry
#14
Thorir Mar Bjorgulfsson, Gerdur Gröndal, Thorsteinn Blondal, Bjorn Gudbjornsson
INTRODUCTION: Treatment with TNFα inhibitors (TNFαi) greatly increases the risk of reactivation of tuberculosis in rheumatic patients. Therefore, it is recommended to screen patients for tuberculosis before initiating TNFαi treatment. Iceland has a low prevalence of tuberculosis and BCG vaccination is not routine praxis. The purpose of this study was to review the results from TB-screening in routine praxis and to analyze whether changes in the screening process are to be recommended...
May 2018: Læknablađiđ
https://www.readbyqxmd.com/read/29695323/evaluation-of-mycobacteria-specific-gamma-interferon-and-antibody-responses-before-and-after-a-single-intradermal-skin-test-in-cattle-naturally-exposed-to-m-avium-subsp-paratuberculosis-and-experimentally-infected-with-m-bovis
#15
Virginie Roupie, Elena Alonso-Velasco, Sarah Van Der Heyden, Sébastien Holbert, Lucille Duytschaever, Patricia Berthon, Iris Van Dosselaer, Willem Van Campe, Laurent Mostin, Franck Biet, Stefan Roels, Kris Huygen, David Fretin
This study reports on the diagnostic potential of IFN-γ release assays and serology for Mycobacterium bovis in six naturally M. avium subsp. paratuberculosis (Map) exposed bulls of which four were intratracheally infected with a Belgian field strain of M. bovis. Heparinized blood, serum and fecal samples were collected at regular time intervals for mycobacteria-specific IFN-γ release assays, antibody analysis and for Map culture respectively. Single intradermal skin test (SIT) with bovine tuberculin (PPD-B) was performed on day 115 and animals were sacrificed on day 133 after M...
February 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29692316/extended-screening-for-infectious-diseases-among-newly-arrived-asylum-seekers-from-africa-and-asia-verona-province-italy-april-2014-to-june-2015
#16
Dora Buonfrate, Federico Gobbi, Valentina Marchese, Chiara Postiglione, Geraldo Badona Monteiro, Giovanni Giorli, Giuseppina Napoletano, Zeno Bisoffi
Background and aimManagement of health issues presented by newly-arrived migrants is often limited to communicable diseases even though other health issues may be more prevalent. We report the results of infectious disease screening proposed to 462 recently-arrived asylum seekers over 14 years of age in Verona province between April 2014 and June 2015. Methods: Screening for latent tuberculosis (TB) was performed via tuberculin skin test (TST) and/or QuantiFERON-TB Gold in-tube assay and/or chest X-ray. An ELISA was used to screen for syphilis...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29686992/the-history-of-in-vivo-tuberculin-testing-in-bovines-tuberculosis-a-one-health-issue
#17
REVIEW
Margaret Good, Douwe Bakker, Anthony Duignan, Daniel M Collins
Tuberculosis (TB) is more than 3 million years old thriving in multiple species. Ancestral Mycobacterium tuberculosis gave rise to multiple strains including Mycobacterium bovis now distributed worldwide with zoonotic transmission happening in both directions between animals and humans. M. bovis in milk caused problems with a significant number of deaths in children under 5 years of age due largely to extrapulmonary TB. This risk was effectively mitigated with widespread milk pasteurization during the twentieth century, and fewer young children were lost to TB...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29663953/cost-effectiveness-of-contact-screening-strategies-for-tuberculosis-among-high-school-adolescents-in-south-korea
#18
H Sohn, H-Y Kim, S H Lee
BACKGROUND: Effective latent tuberculous infection (LTBI) control among adolescents is a critical component of tuberculosis (TB) elimination in Korea. OBJECTIVE: To compare the cost-effectiveness of the following contact screening strategies for LTBI among high-school adolescents after TB outbreaks: QuantiFERON®-TB Gold In-Tube (QFT-GIT), the tuberculin skin test (TST), or TST/QFT-GIT (two-step strategy). METHOD: The costs of post-TB outbreak screening strategies were calculated using a mixed (top-down and bottom-up) cost analysis method and expressed in 2015 US dollars...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29650047/care-cascade-for-targeted-tuberculosis-testing-and-linkage-to-care-in-homeless-populations-in-the-united-states-a-meta-analysis
#19
Andrea Parriott, Mohsen Malekinejad, Amanda P Miller, Suzanne M Marks, Hacsi Horvath, James G Kahn
BACKGROUND: Homelessness increases the risk of tuberculosis (TB) disease and latent TB infection (LTBI), but persons experiencing homelessness often lack access to testing and treatment. We assessed the yield of TB testing and linkage to care for programs targeting homeless populations in the United States. METHODS: We conducted a comprehensive search of peer-reviewed and grey literature, adapting Cochrane systematic review methods. Two reviewers independently assessed study eligibility and abstracted key data on the testing to care cascade: number of persons reached, recruited for testing, tested for LTBI, with valid test results, referred to follow-up care, and initiating care...
April 12, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29642834/-risk-of-travel-associated-tuberculosis
#20
Süheyla Sürücüoğlu
Tuberculosis has spread by human movements throughout history. There have been reports indicating tuberculosis transmission on all travel vehicles, including aircrafts, ground vehicles and vessels until today. However, due to the ever increasing of air transportation and air travelling among countries with low and high tuberculosis incidence, transmission risk especially in aircrafts has become an important issue worldwide. But in many of the studies conducted in this regard, transmission of tuberculosis in aircrafts was found very low...
January 2018: Mikrobiyoloji Bülteni
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