Mariam Almutairi, Katherine Chechalk, Emelia Deane, Rebecca Fox, Ava Janes, Tidgh Maguire-Henry, Devin McCabe, Cole O'Connor, Joseph Quirk, Evan Swan, Katherine White, Kathryn McCreery, Eman Isweisi, Philip Stewart, Aoife Branagan, Edna F Roche, Judith Meehan, Eleanor J Molloy
AIM: Retinopathy of prematurity is a significant global cause of childhood blindness. This study aims to identify serum biomarkers that are associated with the development of ROP. METHODS: A systematic review and meta-analysis was conducted using PRISMA guidelines. Three databases were searched (Pubmed, Scopus and Web of Science) from 2003 to March 2023. Only studies investigating serum biomarker levels in preterm infants (<37 weeks gestation) were included. RESULTS: Meta-analysis suggests that low serum IGF-1 levels have a strong association with the development of ROP [SMD (95% CI) of -...
2024: Frontiers in Pediatrics