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https://www.readbyqxmd.com/read/29913860/treatment-with-topical-capsaicin-experience-from-a-pain-clinic
#1
Marianne Rørbæk, Lise Ventzel, Hanne Gottrup
Background Neuropathic pain is usually treated with antidepressants and anticonvulsant. The use of systemic treatment is, however, limited due to poor tolerability and low efficacy. Qutenza, a topical capsaicin patch (8%), is a relatively new treatment for patients with peripheral neuropathic pain (PNP) conditions. The indication for using topical capsaicin treatment is peripheral neuropathic pain in patients without diabetes. Aim To describe the use of topical capsaicin treatment in a pain clinic in patients with PNP...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29904613/prevalence-of-musculoskeletal-pain-in-association-with-serum-25-hydroxyvitamin-d-concentrations-in-patients-with-type-2-diabetes-mellitus
#2
Mohammad J Alkhatatbeh, Khalid K Abdul-Razzak, Lubna Q Khasawneh, Nesreen A Saadeh
The aim of the present study was to investigate the prevalence of musculoskeletal pain in patients with type 2 diabetes mellitus (T2DM) in association with 25-hydroxyvitamin D levels, anxiety, depression and neuropathy. A cross-sectional study was conducted involving a total of 124 T2DM patients. Musculoskeletal pain was determined by self-reporting of painful body sites. Pain intensity was assessed using a scale of 0-10. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. Neuropathy was assessed using the PainDETECT questionnaire...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29882738/effects-of-low-power-light-therapy-on-the-tissue-repair-process-of-chronic-wounds-in-diabetic-feet
#3
Joelita de Alencar Fonseca Santos, Mariana Barbosa Dias Campelo, Rauirys Alencar de Oliveira, Renata Amadei Nicolau, Verônica Elis Araújo Rezende, Emilia Ângela Loschiavo Arisawa
OBJECTIVE: To analyze the efficacy of the therapeutic use of Low-Level Laser Therapy (LLLT) on the tissue repair process of chronic wounds in patients with diabetic feet through the analysis of Pressure Ulcer Scale for Healing (PUSH) scales, pain and the measurement done using the ImageJ© software. METHODS: This clinical trial was carried out with 18 patients 30-59 years of age, who had chronic wounds on their foot due to complications of diabetes mellitus. The patients were randomly allocated in two different groups of equal numbers: Control and Laser Groups...
June 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29880093/a-case-report-on-pregabalin-induced-eosinophilia
#4
Raj Shilpa, T P Sreekrishnan, K P Gireesh Kumar, C M Neethu
This is a case report on a 77-year-old diabetic patient with peripheral neuropathy and paresthesias in his feet, for which he was treated with pregabalin. During the therapy, his eosinophil level was high (60.3%). Pregabalin was stopped, and after one month his differential eosinophil had dropped dramatically, to 7.3%. Based on the Naranjo Adverse Drug Reaction scale, it is probable that the eosinophilia was induced by pregabalin, as the Naranjo probability score was calculated to be 8. BACKGROUND: Pregabalin, a structural derivative of the inhibitory neurotransmitter gamma amino butyric acid, has antiepileptic, analgesic, and anxiolytic properties; therefore, it is used for painful diabetic neuropathy, postherpetic neuralgia, fibromyalgia, and neuropathic pain associated with spinal-cord injury and as adjunctive therapy in refractory partial seizures...
June 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29865007/painful-diabetic-polyneuropathy-and-quality-of-life-in-danish-type-2-diabetic-patients
#5
Sandra Sif Gylfadottir, Diana Hedevang Christensen, Sia Kromann Nicolaisen, Reimar Wernich Thomsen, Jens Steen Nielsen, Mustapha Itani, Søren Sindrup, Troels Staehelin Jensen, Nanna Brix Finnerup
Background and aims Painful polyneuropathy (PPN) is a disabling complication of diabetes. This study aims to determine its prevalence and relationship with Quality of Life (QoL) in a nationwide prospective cohort of incident recently diagnosed Danish type 2 diabetic patients. Methods We sent a detailed questionnaire on neuropathy, pain and QoL to 6726 patients prospectively enrolled from general practitioners and hospital specialist outpatient clinics into the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29863794/role-of-anaerobes-in-polymicrobial-communities-and-biofilms-complicating-diabetic-foot-ulcers
#6
Steven L Percival, Matthew Malone, Dieter Mayer, Anne-Marie Salisbury, Gregory Schultz
Infected tissues in the feet of people with diabetes in the form of a diabetic foot ulcer (DFU) present a complex pathology for clinicians to manage. This is partly attributed to the multi-factorial nature of the disease, which may include; altered foot architecture leading to excessive plantar pressures and frictional forces peripheral arterial disease and loss of protective sensation. In addition, to the above co-morbid variables, it is understood that a delayed wound healing state may be perpetuated by the presence of microorganisms residing in the wound tissue...
June 4, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29862581/peripheral-neuropathy-in-diabetes-it-s-not-always-what-it-looks-like
#7
G Maltese, S V Tan, E Bruno, A Brackenridge, S Thomas
BACKGROUND: Hereditary Neuropathy with liability to Pressure Palsies (HNPP) is an autosomal dominant neuropathy, associated with deletion of the Peripheral Myelin Protein-22 (PMP-22) gene, causing recurrent painless palsies with age of onset between 10 and 30 years old. Only a few cases of Type 2 Diabetes and HNPP have been described and the coexistence of HNPP and Type 1 diabetes has never been reported. CASE REPORT: A 54-year old man with a history of Type 1 diabetes, managed with continuous subcutaneous insulin infusion (CSII), presented with deterioration of long-standing motor and sensory symptoms, previously attributed to golfer's elbow, diabetic neuropathy and spinal degenerative disease...
June 4, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29860597/diabetic-bone-lesions-a-study-on-38-known-modern-skeletons-and-the-implications-for-forensic-scenarios
#8
Lucie Biehler-Gomez, Elisa Castoldi, Elisa Baldini, Annalisa Cappella, Cristina Cattaneo
Diabetes mellitus is a condition with severe and life-threatening complications and epidemic proportions worldwide. The study of diabetes on bones can provide crucial information to the forensic practice, the archeological field and medical research. In this paper, the authors report and discuss the lesions observed on the skeletons of 38 individuals (plus 11 negative control samples) of the CAL Milano Cemetery Skeletal Collection with known diabetes. As a result, different types of lesions were highlighted in the feet: periosteal new bone formation, lysis of tuft, lytic lesions, evidence of trauma, osteomyelitis, and osteochondritis dissecans...
June 2, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29859061/barriers-to-effective-diabetes-management-a-survey-of-people-with-severe-mental-illness
#9
Kathleen Mulligan, Hayley McBain, Frederique Lamontagne-Godwin, Jacqui Chapman, Chris Flood, Mark Haddad, Julia Jones, Alan Simpson
BACKGROUND: People with severe mental illnesses (SMI) such as schizophrenia and bipolar disorder have an increased risk of developing type 2 diabetes and have poorer health outcomes than those with diabetes alone. To maintain good diabetes control, people with diabetes are advised to engage in several self-management behaviours. The aim of this study was to identify barriers or enablers of diabetes self-management experienced by people with SMI. METHODS: Adults with type 2 diabetes and SMI were recruited through UK National Health Service organisations and mental health and diabetes charities...
June 1, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29857779/foot-care-spousal-support-and-type-2-diabetes-an-exploratory-qualitative-study
#10
Matthew Reaney, Nik Chmiel, Susan Churchill
OBJECTIVES: People with type 2 diabetes (T2DM) should check their feet and protect them against harm, but few do. Living with a spouse contributes to good foot care behaviour. This study explores awareness, perceived susceptibility of, and concern about, foot problems, and reported foot care behaviour, and ways in which a spouse may or may not contribute to foot care in T2DM. METHODS: 1:1 interviews were conducted with 6 individuals with T2DM. Half had a spouse half did not...
June 1, 2018: Psychology & Health
https://www.readbyqxmd.com/read/29808737/easier-operation-and-similar-power-of-10-g-monofilament-test-for-screening-diabetic-peripheral-neuropathy
#11
Qi Zhang, Na Yi, Siying Liu, Hangping Zheng, Xiaona Qiao, Qian Xiong, Xiaoxia Liu, Shuo Zhang, Jie Wen, Hongying Ye, Linuo Zhou, Yiming Li, Renming Hu, Bin Lu
Objective The 10 g Semmes-Weinstein monofilament evaluation (SWME) of 4 sites on each foot is recommended for distal symmetric polyneuropathy screening and diagnosis. A similar method has been proposed to diagnose 'high-risk' (for ulceration) feet, using 3 sites per foot. This study compared the effectiveness of SWME for testing 3, 4 and 10 sites per foot to identify patients with diabetic neuropathy. Methods We included 3497 subjects in a SWME of 10 sites; records from the 10-site SWME were used for a SWME of 3 and 4 sites...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29806391/-application-of-modified-adjustable-skin-stretching-and-secure-wound-closure-system-in-repairing-of-skin-and-soft-tissue-defect
#12
Qiqiang Dong, Guojun Gu, Lijun Wang, Keda Fu, Shuqiang Xie, Songjian Zhang, Huafeng Zhang, Zhaosen Wu
Objective: To investigate the application of modified adjustable skin stretching and secure wound-closure system in repairing of skin and soft tissue defect. Methods: Between March 2016 and April 2017, 21 cases of skin and soft tissue defects were repaired with the modified adjustable skin stretching and secure wound-closure system (the size of regulating pressure and the times of adjustment were determined according to the color, temperature, capillary response, and swelling degree of the skin edge)...
December 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29796321/mistaken-diabetic-ulcers-a-case-of-bilateral-foot-verrucous-carcinoma
#13
Vanessa Di Palma, Jill P Stone, Andrew Schell, Jeffrey C Dawes
Verrucous carcinoma (VC) is a rare, low-grade, and well-differentiated variant of squamous cell carcinoma. These tumors are slow-growing and exophytic and have a negligible incidence of metastasis. Treatment is complete surgical resection, ideally by Mohs micrographic surgery, to ensure adequate clear margins. Cutaneous VC predominantly occurs on the plantar surface of the foot and rarely occurs in multiple sites. This case study describes the fourth reported occurrence of bilateral VC of the feet in a woman with chronic diabetic foot ulcers...
2018: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29784531/comparison-of-pedal-soft-tissue-thickness-between-those-with-and-without-diabetes
#14
Sangho Oh, Junhyung Kim, Jaehoon Choi, Woonhyeok Jeong, Hyukwon Chang, Soyoung Lee
Ulceration is a serious consequence of diabetes that can lead to disability in patients with diabetes. One of the risk factors for ulceration is high foot pressure. The thickness of the pedal soft tissue is important because it has a cushioning effect. Soft tissue atrophy causes elevation in the plantar pressure, which, in turn, causes ischemia. Therefore, we investigated the severity of pedal soft tissue atrophy caused by diabetes and aging. From February 2009 to February 2016, we examined the feet of 261 patients treated in our hospital using magnetic resonance imaging...
May 18, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29782416/acellular-flowable-matrix-in-the-treatment-of-tunneled-or-cavity-ulcers-in-diabetic-feet-a-preliminary-report
#15
Ferdinando Campitiello, Manfredi Mancone, Angela Della Corte, Raffaella Guerniero, Silvestro Canonico
OBJECTIVE: The authors aimed to explore the feasibility and safety of an advanced, acellular, flowable wound matrix (FWM) in patients with diabetes-related cavity or tunnel lesions involving deep structures. METHODS: Patients with diabetic foot ulcers were hospitalized at the General and Geriatric Surgery Unit of the University of Campania in Naples, Italy, between March 2015 and December 2015. Twenty-three patients with tunneled or cavity ulcers were treated. The lesions were filled with the FWM...
June 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29779710/comorbidity-network-for-chronic-disease-a-novel-approach-to-understand-type-2-diabetes-progression
#16
Arif Khan, Shahadat Uddin, Uma Srinivasan
BACKGROUND: Chronic diseases management outside expensive hospital settings has become a major target for governments, funders and healthcare service providers. It is well known that chronic diseases such as Type 2 Diabetes (T2D) do not occur in isolation, and has a shared aetiology common to many other diseases and disorders. Diabetes Australia reports that it is associated with a myriad of complications, which affect the feet, eyes, kidneys, and cardiovascular health. For instance, nerve damage in the lower limbs affects around 13% of Australians with diabetes, diabetic retinopathy occurs in over 15% of Australians with diabetes, and diabetes is now the leading cause of end-stage kidney disease...
July 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29753996/risk-factors-for-diabetic-foot-ulcer-recurrence-a-prospective-2-year-follow-up-study-in-egypt
#17
Walaa A Khalifa
OBJECTIVES: To determine the frequency of diabetic foot ulcer recurrence and its potential risk factors. METHODS: This study included 93 patients with type 2 diabetes and followed for 2 years after primary healed foot ulceration. Demographic, diabetes related, comorbid and ulcer related variables were investigated as risk factors. Multiple logistic regression analysis was used to identify independent risk factors. RESULTS: 61.3% of patients had recurrent ulcers particularly in the forefoot (33...
December 28, 2017: Foot
https://www.readbyqxmd.com/read/29748311/radiotracer-imaging-allows-for-noninvasive-detection-and-quantification-of-abnormalities-in-angiosome-foot-perfusion-in-diabetic-patients-with-critical-limb-ischemia-and-nonhealing-wounds
#18
Jessica L Alvelo, Xenophon Papademetris, Carlos Mena-Hurtado, Sangchoon Jeon, Bauer E Sumpio, Albert J Sinusas, Mitchel R Stacy
BACKGROUND: Single photon emission computed tomography (SPECT)/computed tomography (CT) imaging allows for assessment of skeletal muscle microvascular perfusion but has not been quantitatively assessed in angiosomes, or 3-dimensional vascular territories, of the foot. This study assessed and compared resting angiosome foot perfusion between healthy subjects and diabetic patients with critical limb ischemia (CLI). Additionally, the relationship between SPECT/CT imaging and the ankle-brachial index-a standard tool for evaluating peripheral artery disease-was assessed...
May 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29738280/identifying-and-treating-foot-ulcers-in-patients-with-diabetes-saving-feet-legs-and-lives
#19
Karen Ousey, Paul Chadwick, Arkadiusz Jawien, Gulnaz Tariq, Harikrishna K Ragavan Nair, José Luis Lázaro-Martínez, Kylie Sandy-Hodgetts, Paulo Alves, Stephanie Wu, Zena Moore
No abstract text is available yet for this article.
May 1, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29721019/establishing-differences-in-thermographic-patterns-between-the-various-complications-in-diabetic-foot-disease
#20
Alfred Gatt, Owen Falzon, Kevin Cassar, Christian Ellul, Kenneth P Camilleri, Jean Gauci, Stephen Mizzi, Anabelle Mizzi, Cassandra Sturgeon, Liberato Camilleri, Nachiappan Chockalingam, Cynthia Formosa
Aim: To evaluate the potential of thermography as an assessment tool for the detection of foot complications by understanding the variations in temperature that occur in type 2 diabetes mellitus (DM). Methods: Participants were categorized according to a medical examination, ankle brachial index, doppler waveform analysis, and 10-gram monofilament testing into five groups: healthy adult, DM with no complications, DM with peripheral neuropathy, DM with neuroischaemia, and DM with peripheral arterial disease (PAD) groups...
2018: International Journal of Endocrinology
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