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Protein energy wasting

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https://www.readbyqxmd.com/read/28802091/a-cyclic-and-intermittent-very-low-protein-diet-can-have-beneficial-effects-against-advanced-diabetic-nephropathy-in-wistar-fatty-fa-fa-rats-an-animal-model-of-type-2-diabetes-and-obesity
#1
Munehiro Kitada, Yoshio Ogura, Taeko Suzuki, Itaru Monnno, Keizo Kanasaki, Ai Watanabe, Daisuke Koya
A low-protein diet (LPD), particularly, very low-protein diet (VLPD) is expected for reno-protection in advanced chronic kidney disease, including diabetic nephropathy. We previously also demonstrated that a VLPD clearly improved advanced diabetic nephropathy in a type 2 diabetes and obesity rat. However, clinically, an everyday long-term VLPD contributes to poor adherence, which may be related to controvertial results of an LPD on the suppression for diabetic nephropathy, and has nutritional issues, such as sarcopenia or protein-energy wasting...
August 12, 2017: Nephrology
https://www.readbyqxmd.com/read/28767700/environmental-impacts-of-food-consumption-by-dogs-and-cats
#2
Gregory S Okin
In the US, there are more than 163 million dogs and cats that consume, as a significant portion of their diet, animal products and therefore potentially constitute a considerable dietary footprint. Here, the energy and animal-derived product consumption of these pets in the US is evaluated for the first time, as are the environmental impacts from the animal products fed to them, including feces production. In the US, dogs and cats consume about 19% ± 2% of the amount of dietary energy that humans do (203 ± 15 PJ yr-1 vs...
2017: PloS One
https://www.readbyqxmd.com/read/28760431/predicting-clinical-outcomes-using-phase-angle-as-assessed-by-bioelectrical-impedance-analysis-in-maintenance-hemodialysis-patients
#3
Jung-Ho Shin, Chae Rim Kim, Ki Hyun Park, Jin Ho Hwang, Su Hyun Kim
OBJECTIVE: Protein-energy wasting is common in patients on hemodialysis and is an independent risk factor for adverse events. The aim of this study was to retrospectively investigate whether phase angle (PA), known as a nutritional marker, can predict various clinical outcomes in patients with end-stage renal disease (ESRD) who are receiving hemodialysis. METHODS: Using bioelectrical impedance analysis (BIA), PA was obtained every 6 mo, and patients were divided into two groups according to baseline PA: group A included patients with PA ≥4...
September 2017: Nutrition
https://www.readbyqxmd.com/read/28760111/differences-in-prevalence-of-muscle-wasting-in-patients-receiving-peritoneal-dialysis-per-dual-energy-x-ray-absorptiometry-due-to-variation-in-guideline-definitions-of-sarcopenia
#4
Rachel Hung, Bethany Wong, Gabrielle Goldet, Andrew Davenport
BACKGROUND: Muscle wasting is associated with increased risk for mortality. There is no agreed universal definition for muscle wasting (sarcopenia), and we wished to determine whether using different criteria altered the prevalence in patients treated by peritoneal dialysis. METHODS: We measured lean body and appendicular lean mass indices in 325 outpatients by dual-energy x-ray absorptiometry, comparing muscle mass with that used to define muscle wasting (sarcopenia) by various clinical guideline publications...
August 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28758978/dietary-approaches-in-the-management-of-diabetic-patients-with-kidney-disease
#5
REVIEW
Gang Jee Ko, Kamyar Kalantar-Zadeh, Jordi Goldstein-Fuchs, Connie M Rhee
Chronic kidney disease (CKD) is one of the most prevalent complications of diabetes, and patients with diabetic kidney disease (DKD) have a substantially higher risk of cardiovascular disease and death compared to their non-diabetic CKD counterparts. In addition to pharmacologic management strategies, nutritional and dietary interventions in DKD are an essential aspect of management with the potential for ameliorating kidney function decline and preventing the development of other end-organ complications. Among DKD patients with non-dialysis dependent CKD, expert panels recommend lower dietary protein intake of 0...
July 31, 2017: Nutrients
https://www.readbyqxmd.com/read/28755901/protein-energy-wasting-syndrome-in-advanced-chronic-kidney-disease-prevalence-and-specific-clinical-characteristics
#6
Almudena Pérez-Torres, M Elena González Garcia, Belén San José-Valiente, M Auxiliadora Bajo Rubio, Olga Celadilla Diez, Ana M López-Sobaler, Rafael Selgas
INTRODUCTION: Protein-energy wasting (PEW) is associated with increased mortality and differs depending on the chronic kidney disease (CKD) stage and the dialysis technique. The prevalence in non-dialysis patients is understudied and ranges from 0 to 40.8%. OBJECTIVE: To evaluate the nutritional status of a group of Spanish advanced CKD patients by PEW criteria and subjective global assessment (SGA). PATIENTS AND METHODS: Cross-sectional study of 186 patients (101 men) with a mean age of 66...
July 26, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28750066/cross-modulation-of-pathogen-specific-pathways-enhances-malnutrition-during-enteric-co-infection-with-giardia-lamblia-and-enteroaggregative-escherichia-coli
#7
Luther A Bartelt, David T Bolick, Jordi Mayneris-Perxachs, Glynis L Kolling, Gregory L Medlock, Edna I Zaenker, Jeffery Donowitz, Rose Viguna Thomas-Beckett, Allison Rogala, Ian M Carroll, Steven M Singer, Jason Papin, Jonathan R Swann, Richard L Guerrant
Diverse enteropathogen exposures associate with childhood malnutrition. To elucidate mechanistic pathways whereby enteric microbes interact during malnutrition, we used protein deficiency in mice to develop a new model of co-enteropathogen enteropathy. Focusing on common enteropathogens in malnourished children, Giardia lamblia and enteroaggregative Escherichia coli (EAEC), we provide new insights into intersecting pathogen-specific mechanisms that enhance malnutrition. We show for the first time that during protein malnutrition, the intestinal microbiota permits persistent Giardia colonization and simultaneously contributes to growth impairment...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28731598/comparison-of-malnutrition-inflammation-score-anthropometry-and-biochemical-parameters-in-assessing-the-difference-in-protein-energy-wasting-between-normal-weight-and-obese-patients-undergoing-haemodialysis
#8
Elham Alipoor, Mohammad Javad Hosseinzadeh-Attar, Mitra Mahdavi-Mazdeh, Mehdi Yaseri, Narges S Zahed
AIM: Protein-energy wasting (PEW) is prevalent in haemodialysis. Obesity is an independent risk factor of kidney insufficiency, but it is proposed to have beneficial roles in better outcomes in the final stage of disease. Better nutritional status and body reserves are among probable mechanisms, but direct examinations are limited. The present study aimed to investigate whether obese patients have preferable nutritional status compared to normal weight patients based on malnutrition inflammation score (MIS) and other PEW parameters in haemodialysis...
July 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28703894/comparison-of-resting-energy-equations-and-total-energy-expenditure-in-haemodialysis-patients-and-body-composition-measured-by-multi-frequency-bioimpedance
#9
Ben Oliveira, Sivakumar Sridharan, Ken Farrington, Andrew Davenport
BACKGROUND: Waste products of metabolism are retained in haemodialysis (HD) patients. Cellular metabolism generates energy, and patients with greater energy expenditure may therefore require more dialysis. To determine the amount of dialysis required, equations estimating resting and total energy expenditure (REE,TEE) are required. METHODS: We compared estimates of REE in HD patients using established equations with a novel equation recently validated in HD patients (HD equation)...
July 13, 2017: Nephrology
https://www.readbyqxmd.com/read/28699849/protein-energy-wasting-significantly-increases-healthcare-utilization-and-costs-among-patients-with-chronic-kidney-disease-a-propensity-score-matched-cohort-study
#10
Chia-Ter Chao, Chao-Hsiun Tang, Rhoda Wen-Yi Cheng, Michael Yao-Hsien Wang, Kuan-Yu Hung
BACKGROUND: Disease-related malnutrition is highly prevalent, and has prognostic implications for patients with chronic kidney disease (CKD); however, few studies have investigated the impact of malnutrition, or protein-energy wasting (PEW), on healthcare utilization and medical expenditure among CKD patients. METHODS: Using claim data from the National Health Insurance in Taiwan, this study identified patients with CKD between 2009-2013 and categorized them into those with mild, moderate, or severe CKD...
July 31, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28689054/implementing-qm-in-docking-calculations-is-it-a-waste-of-computational-time
#11
Adebayo A Adeniyi, Mahmoud E S Soliman
The greatest challenge in molecular docking (MD) is the deficiency of scoring functions (SFs), which limits their reliability. SFs are too simplified to represent the true features of the complex free energy of protein-ligand interactions. Investigations of docking functions have traded accuracy for speed through the use of approximations and simplifications. Consequently, there has been an increase in the popularity of quantum-mechanical (QM)-based methods as reference points for the development of fast, reliable, valuable, yet inexpensive, tools...
July 5, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28676228/room-service-improves-nutritional-intake-and-increases-patient-satisfaction-while-decreasing-food-waste-and-cost
#12
Sally McCray, Kirsty Maunder, Renee Krikowa, Kristen MacKenzie-Shalders
BACKGROUND: Room service is a foodservice model that has been increasingly implemented across health care facilities in an effort to improve patient satisfaction and reduce food waste. In 2013, Mater Private Hospital Brisbane, Australia, was the first hospital in Australia to implement room service, with the aim of improving patient nutrition care and reducing costs. OBJECTIVE: The aim of this study was to comprehensively evaluate the nutritional intake, plate waste, patient satisfaction, and patient meal costs of room service compared to a traditional foodservice model...
July 1, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28661565/a-brief-review-of-intradialytic-hypotension-with-a-focus-on-survival
#13
Jason A Chou, Kamyar Kalantar-Zadeh, Anna T Mathew
Intradialytic hypotension (IDH), a common complication of ultrafiltration during hemodialysis therapy, is associated with high mortality and morbidity. IDH, defined as a nadir systolic blood pressure of less than 90 mm Hg on more than 30% of treatments, is a relevant definition and is correlated with mortality. Risk factors for IDH include patient demographics, anti-hypertensive medication use, larger interdialytic weight gain, and dialysis prescription features as dialysate sodium, high ultrafiltration rate, and dialysate temperature...
June 29, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28659014/optimizing-nutrition-in-pediatric-heart-failure-the-crisis-is-over-and-now-it-s-time-to-feed
#14
Kylie D Lewis, Jennifer Conway, Chentel Cunningham, Bodil M K Larsen
Pediatric heart failure is a complex disease occurring when cardiac output is unable to meet the metabolic demands of the body. With improved surgical interventions and medical therapies, survival rates have improved, and care has shifted from focusing on survival to optimizing quality of life and health outcomes. Based on current literature, this review addresses the nutrition needs of infants and children in heart failure and describes the pathophysiology and metabolic implications of this disease. The prevalence of wasting in pediatric heart failure has been reported to be as high as 86%, highlighting the importance of nutrition assessment through all stages of treatment to provide appropriate intake of energy, protein, and micronutrients...
June 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28658963/chemical-composition-and-physicochemical-properties-of-phaeodactylum-tricornutum-microalgal-residual-biomass
#15
L J German-Báez, M A Valdez-Flores, J V Félix-Medina, C D Norzagaray-Valenzuela, D U Santos-Ballardo, C Reyes-Moreno, L M Shelton, A Valdez-Ortiz
The production of photosynthetic biofuels using microalgae is a promising strategy to combat the use of non-renewable energy sources. The microalgae residual biomass is a waste by-product of biofuel production; however, it could prove to have utility in the development of sustainable nutraceuticals and functional foods. In this study, a comprehensive characterisation of the under-utilised Phaeodactylum tricornutum microalgae residual biomass is presented. Proximal composition, antioxidant capacity (using three different antioxidant assays; oxygen radical absorbance capacity; radical cation activity, ABTS; and radical scavenging activity, DPPH), and total phenolic content of free and bound polyphenols were determined...
January 1, 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28634773/development-and-validation-of-a-fall-risk-assessment-index-for-dialysis-patients
#16
Kenichi Kono, Yusuke Nishida, Hiroki Yabe, Yoshihumi Moriyama, Toshihiko Mori, Ryota Shiraki, Takashi Sato
BACKGROUND: Dialysis patients often have low physical performance due to uremic sarcopenia, protein energy wasting (PEW), and incidence intradialytic hypotension (IDH), which are indicated as risk factors for falling. The objective of this study was to develop a symptom-encompassing evaluation form to predict falls with high sensitivity for dialysis patients. METHODS: A total of 251 patients who had been receiving maintenance hemodialysis therapy three times a week were enrolled in the study...
June 20, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28634051/revisiting-interdialytic-weight-gain-and-mortality-association-with-serum-albumin-interactions-the-japanese-dialysis-outcomes-and-practice-pattern-study
#17
Noriaki Kurita, Yasuaki Hayashino, Shin Yamazaki, Tadao Akizawa, Takashi Akiba, Akira Saito, Shunichi Fukuhara
BACKGROUND: The dialysis practice guideline in Japan sets a limit on the allowed interdialytic weight gain (IDWG) <6%. However, the effects of relative gain of fluid volume to body weight may differ in presence of morbid conditions. Here, we examined whether or not the associations between IDWG and mortality differ by serum albumin (sAlb), a nutritional and illness marker. DESIGN: The study type used was prospective cohort study. SUBJECTS: Patients who participated in the Japan Dialysis Outcomes and Practice Pattern Study (phase 1-4 [1999-2011]) and received thrice-weekly hemodialysis...
June 17, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28633456/feeding-during-dialysis-risks-and-uncertainties
#18
Rajiv Agarwal, Panagiotis Georgianos
Allowing dialysis patients to eat during the treatment is controversial. It is, therefore, no surprise that practices and policies with respect to intradialytic food consumption vary considerably from unit to unit and from country to country. Those who defend the position of feeding during dialysis reason that intradialytic meals offer a supervised and effective therapy for protein-energy wasting. Those who take the opposite view argue that intradialytic food intake should be avoided for the following three reasons...
June 19, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28631898/mass-spectrometry-based-protein-analytics-to-unravel-the-tissue-pathophysiology-in-duchenne-muscular-dystrophy
#19
Stephanie J Carr, René P Zahedi, Hanns Lochmüller, Andreas Roos
Duchenne muscular dystrophy (DMD) is a genetic muscle wasting condition with limited treatment options available and is caused by the lack of Dystrophin. However, pathophysiology of different tissues is variable showing different histological and molecular signatures. Recently, a number of studies have employed gel-free proteomic approaches to unveil the molecular pathophysiology in terms of tissue-specific proteome changes in dystrophin-deficiency. We analysed studies in models of dystrophin-deficiency and patients both from the published literature...
June 20, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28625985/periplasmic-nicotine-dehydrogenase-ndhab-utilizes-pseudoazurin-as-its-physiological-electron-acceptor-in-agrobacterium-tumefaciens-s33
#20
Wenjun Yu, Rongshui Wang, Haiyan Huang, Huijun Xie, Shuning Wang
Agrobacterium tumefaciens S33 can grow with nicotine as the sole source of carbon, nitrogen, and energy via a novel hybrid of the pyridine pathway and the pyrollidine pathway. Characterization of the enzymes involved in the hybrid pathway is important for understanding its biochemical mechanism. Here we report that the molybdenum-containing nicotine dehydrogenase (NdhAB), which catalyzes the initial step of nicotine degradation, is located in the periplasm of strain S33, while the 6-hydroxynicotine oxidase and 6-hydroxypseudooxynicoine oxidase are in the cytoplasm...
June 16, 2017: Applied and Environmental Microbiology
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