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Protein energy wasting

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https://www.readbyqxmd.com/read/29337225/bone-muscle-and-metabolic-parameters-predict-survival-in-patients-with-synchronous-bone-metastases-from-lung-cancers
#1
Lauriane Chambard, Nicolas Girard, Edouard Ollier, Jean-Charles Rousseau, François Duboeuf, Marie-Christine Carlier, Marie Brevet, Pawel Szulc, Jean-Baptiste Pialat, Julien Wegrzyn, Philippe Clezardin, Cyrille B Confavreux
BACKGROUND: Lung adenocarcinoma regularly induces bone metastases that are responsible for impaired quality of life as well as significant morbidity, including bone pain and fractures. We aimed at identifying whether bone and metabolic biomarkers were associated with the prognosis of lung adenocarcinoma patients with synchronous bone metastases. PATIENTS AND METHODS: POUMOS is a prospective cohort of patients diagnosed with lung adenocarcinoma and synchronous bone metastases...
January 11, 2018: Bone
https://www.readbyqxmd.com/read/29335453/engineering-yarrowia-lipolytica-to-simultaneously-produce-lipase-and-single-cell-protein-from-agro-industrial-wastes-for-feed
#2
Jinyong Yan, Bingnan Han, Xiaohua Gui, Guilong Wang, Li Xu, Yunjun Yan, Catherine Madzak, Dujie Pan, Yaofeng Wang, Genhan Zha, Liangcheng Jiao
Lipases are scarcely exploited as feed enzymes in hydrolysis of lipids for increasing energy supply and improving nutrient use efficiency. In this work, we performed homologous overexpression, in vitro characterization and in vivo assessment of a lipase from the yeast Yarrowia lipolytica for feed purpose. Simultaneously, a large amount of yeast cell biomass was produced, for use as single cell protein, a potential protein-rich feed resource. Three kinds of low cost agro-industrial wastes were tested as substrates for simultaneous production of lipase and single cell protein (SCP) as feed additives: sugarcane molasses, waste cooking oil and crude glycerol from biodiesel production...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322369/proteomic-and-metabolomic-analysis-of-marine-medaka-oryzias-melastigma-after-acute-ammonia-exposure
#3
Limei Zhu, Na Gao, Ruifang Wang, Li Zhang
Ammonia is both a highly toxic environmental pollutant and the major nitrogenous waste produced by ammoniotelic teleosts. Although the acute toxic effects of ammonia have been widely studied in fish, the biochemical mechanisms of its toxicity have not been understood comprehensively. In this study, we performed comparative proteomic and metabolomic analysis between ammonia-challenged (1.2 and 2.6 mmol L-1 NH4Cl for 96 h) and control groups of marine medaka (Oryzias melastigma) to identify changes of the metabolite and protein profiles in response to ammonia stress...
January 10, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29315539/fasting-or-fear-disentangling-the-roles-of-predation-risk-and-food-deprivation-in-the-nitrogen-metabolism-of-consumers
#4
Christopher M Dalton, Karen E Tracy, Nelson G Hairston, Alexander S Flecker
Predators can alter nutrient cycles simply by inducing stress in prey. This stress accelerates prey's protein catabolism, nitrogen waste production, and nitrogen cycling. Yet predators also reduce the feeding rates of their prey, inducing food deprivation that is expected to slow protein catabolism and nitrogen cycling. The physiology of prey under predation risk thus balances the influences of predation risk and food deprivation, and this balance is central to understanding the role of predators in nutrient cycles...
January 7, 2018: Ecology
https://www.readbyqxmd.com/read/29280657/-assessment-of-diet-in-patients-with-chronic-kidney-diseases-without-dialysis-and-relationship-with-the-nutritional-status
#5
Almudena Pérez Torres, María Elena González García, Ana María López Sobaler, Rafael Jesús Sánchez Villanueva, Rafael Selgas Gutiérrez
BACKGROUND: Diet is one of the pillars of the treatment for patients with chronic kidney disease without dialysis (NDD-CKD). Despite this, very few studies have evaluated the diet in Spanish population. OBJECTIVE: To evaluate the diet of a group of patients with advanced CKD, comparing it with the recommendations, and its relation with nutritional status. MATERIAL AND METHODS: A cross-sectional study of 74 patients (39 men), with a mean age of 70...
October 27, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29280654/food-intake-plate-waste-and-its-association-with-malnutrition-in-hospitalized-patients
#6
Kobra Simzari, Davoud Vahabzadeh, Sakineh Nouri Saeidlou, Susan Khoshbin, Yener Bektas
BACKGROUND: Hospital malnutrition is a worldwide dilemma and challenge. High levels of plate waste contribute to malnutrition-related complications in hospital. We investigated the association between the levels of plate waste, food intake and patient satisfaction with nutritional risk and malnutrition prevalence in three hospital settings. METHODS: The sample population of 120 patients, aged 18-65 year, admitted consecutively over a 12 month period to 3 different educational university hospitals was included...
November 16, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29249295/eating-during-hemodialysis-treatment-a%C3%A2-consensus-statement-from-the-international-society-of-renal-nutrition-and-metabolism
#7
REVIEW
Brandon M Kistler, Debbie Benner, Jerrilynn D Burrowes, Katrina L Campbell, Denis Fouque, Giacomo Garibotto, Joel D Kopple, Csaba P Kovesdy, Connie M Rhee, Alison Steiber, Peter Stenvinkel, Pieter Ter Wee, Daniel Teta, Angela Y M Wang, Kamyar Kalantar-Zadeh
Poor nutritional status and protein-energy wasting are common among maintenance dialysis patients and associated with unfavorable outcomes. Providing foods, meal trays, snack boxes, and/or oral nutritional supplements during hemodialysis can improve nutritional status and might also reduce inflammation, enhance health-related quality of life, boost patient satisfaction, and improve survival. Potential challenges include postprandial hypotension and other hemodynamic instabilities, aspiration risk, gastrointestinal symptoms, hygiene issues, staff burden, reduced solute removal, and increased costs...
January 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29248920/association-between-comprehensive-nutritional-scoring-system-cnss-and-outcomes-of-continuous-ambulatory-peritoneal-dialysis-patients
#8
Xingqun Yan, Xin Yang, Xishao Xie, Shilong Xiang, Xiaohui Zhang, Zhangfei Shou, Jianghua Chen
BACKGROUND/AIMS: The presence of protein-energy wasting (PEW) among dialysis patients is a crucial risk factor for outcomes. The complicated pathogenesis of PEW makes it difficult to assess and treat. This single-center retrospective study focuses on the association between nutritional markers and the outcomes of continuous ambulatory peritoneal dialysis(CAPD) patients, aiming to establish a practical comprehensive nutritional scoring system for CAPD patients. METHODS: 924 patients who initiated peritoneal dialysis in our center from January 1st,2005 to December 31st,2015 were enrolled...
December 14, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29248911/irisin-and-volume-overload-are-associated-with-protein-energy-wasting-in-peritoneal-dialysis-patients
#9
Si-Jia Zhou, Qing-Feng Han, Ai-Hua Zhang, Wen Tang, Ling-Hua Sun
BACKGROUND/AIMS: Protein energy wasting (PEW) is a common medical phenomenon that is observed in maintenance dialysis patients. PEW also increases morbidity and mortality of these patients. Its pathogenesis is unclear. We hypothesize that serum irisin levels and volume overload may induce PEW in peritoneal dialysis (PD) patients. The aim of this study is to measure serum irisin levels, evaluate volume status of PD patients, and study their correlations with PEW in PD patients. METHODS: This study is a cross-sectional study with 160 PD patients from the PD center of Peking University Third Hospital and 35 healthy control subjects...
December 14, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29241534/integrating-extracellular-flux-measurements-and-genome-scale-modeling-reveals-differences-between-brown-and-white-adipocytes
#10
Alfred K Ramirez, Matthew D Lynes, Farnaz Shamsi, Ruidan Xue, Yu-Hua Tseng, C Ronald Kahn, Simon Kasif, Jonathan M Dreyfuss
White adipocytes are specialized for energy storage, whereas brown adipocytes are specialized for energy expenditure. Explicating this difference can help identify therapeutic targets for obesity. A common tool to assess metabolic differences between such cells is the Seahorse Extracellular Flux (XF) Analyzer, which measures oxygen consumption and media acidification in the presence of different substrates and perturbagens. Here, we integrate the Analyzer's metabolic profile from human white and brown adipocytes with a genome-scale metabolic model to predict flux differences across the metabolic map...
December 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/29225699/3-hydroxypropionaldehyde-production-from-crude-glycerol-by-lactobacillus-diolivorans-with-enhanced-glycerol-uptake
#11
Katharina Anna Lindlbauer, Hans Marx, Michael Sauer
Background: In their quest for sustainable development and effective management of greenhouse gas emissions, our societies pursue a shift away from fossil-based resources towards renewable resources. With 95% of our current transportation energy being petroleum based, the application of alternative, carbon-neutral products-among them biodiesel-is inevitable. In order to enhance the cost structure of biodiesel biorefineries, the valorization of the crude glycerol waste stream into high-value platform chemicals is of major importance...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29221626/effects-of-oral-nutritional-supplements-on-mortality-missed-dialysis-treatments-and-nutritional-markers-in-hemodialysis-patients
#12
Debbie Benner, Steven M Brunelli, Becky Brosch, Jane Wheeler, Allen R Nissenson
OBJECTIVE: Protein-energy wasting is common in end-stage renal disease patients undergoing dialysis and is strongly associated with mortality and adverse outcomes. Intradialytic oral nutritional supplements (ONS) reduce risk of mortality in these patients. Large studies characterizing the impact of ONS on other outcomes are lacking. We assessed the associations between administration of ONS and clinical and nutritional outcomes. DESIGN: Retrospective evaluation of a pilot program providing ONS to patients at a large dialysis organization in the United States...
December 5, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29211778/clinical-global-assessment-of-nutritional-status-as-predictor-of-mortality-in-chronic-kidney-disease-patients
#13
Lu Dai, Hideyuki Mukai, Bengt Lindholm, Olof Heimbürger, Peter Barany, Peter Stenvinkel, Abdul Rashid Qureshi
BACKGROUND: The value of subjective global assessment (SGA) as nutritional assessor of protein-energy wasting (PEWSGA) in chronic kidney disease (CKD) patients depends on its mortality predictive capacity. We investigated associations of PEWSGA with markers of nutritional status and all-cause mortality in CKD patients. METHODS: In 1031 (732 CKD1-5 non-dialysis and 299 dialysis) patients, SGA and body (BMI), lean (LBMI) and fat (FBMI) body mass indices, % handgrip strength (% HGS), serum albumin, and high sensitivity C-reactive protein (hsCRP) were examined at baseline...
2017: PloS One
https://www.readbyqxmd.com/read/29198312/coupling-of-anaerobic-waste-treatment-to-produce-protein-and-lipid-rich-bacterial-biomass
#14
Lisa M Steinberg, Rachel E Kronyak, Christopher H House
Future long-term manned space missions will require effective recycling of water and nutrients as part of a life support system. Biological waste treatment is less energy intensive than physicochemical treatment methods, yet anaerobic methanogenic waste treatment has been largely avoided due to slow treatment rates and safety issues concerning methane production. However, methane is generated during atmosphere regeneration on the ISS. Here we propose waste treatment via anaerobic digestion followed by methanotrophic growth of Methylococcus capsulatus to produce a protein- and lipid-rich biomass that can be directly consumed, or used to produce other high-protein food sources such as fish...
November 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29187037/modeling-a-predictive-energy-equation-specific-for-maintenance-hemodialysis
#15
Laura D Byham-Gray, J Scott Parrott, Emily N Peters, Susan Gould Fogerite, Rosa K Hand, Sean Ahrens, Andrea Fleisch Marcus, Justin J Fiutem
BACKGROUND: Hypermetabolism is theorized in patients diagnosed with chronic kidney disease who are receiving maintenance hemodialysis (MHD). We aimed to distinguish key disease-specific determinants of resting energy expenditure to create a predictive energy equation that more precisely establishes energy needs with the intent of preventing protein-energy wasting. MATERIALS AND METHODS: For this 3-year multisite cross-sectional study (N = 116), eligible participants were diagnosed with chronic kidney disease and were receiving MHD for at least 3 months...
March 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29174562/an-even-distribution-of-protein-intake-daily-promotes-protein-adequacy-but-does-not-influence-nutritional-status-in-institutionalized-elderly
#16
Michael Tieland, Janne Beelen, Anna C M Laan, Shirley Poon, Lisette C P G M de Groot, Ego Seeman, Xiaofang Wang, Sandra Iuliano
OBJECTIVE: Although it has been established that sufficient protein is required to maintain good nutritional status and support healthy aging, it is not clear if the pattern of protein consumption may also influence nutritional status, especially in institutionalized elderly who are at risk of malnutrition. Therefore, we aim to determine the association between protein intake distribution and nutritional status in institutionalized elderly people. DESIGN: Cross-sectional study among 481 institutionalized older adults...
November 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29169913/the-strategic-function-of-the-p5-atpase-atp13a2-in-toxic-waste-disposal
#17
Felicitas de Tezanos Pinto, Hugo Pedro Adamo
The P-type ATPase ATP13A2 protein was originally associated with a form of Parkinson's Disease (PD) known as Kufor Rakeb Syndrome (KRS). However, in the last years it has been found to underlay variants of neuronal ceroid-lipofuscinoses and hereditary spastic paraplegia. These findings expand the clinical and genetic spectrum of ATP13A2-associated disorders, which are commonly characterized by lysosomal dysfunction. Nowadays it is well known that lysosomes are not merely related to the degradation and recycling of cellular waste, but are also involved in fundamental processes such as secretion, plasma membrane repair, signaling, energy metabolism and autophagy...
November 20, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29167757/amino-acid-catabolism-directed-biofuel-production-in-clostridium-sticklandii-an-insight-into-model-driven-systems-engineering
#18
REVIEW
C Sangavai, P Chellapandi
Model-driven systems engineering has been more fascinating process for the microbial production of biofuel and bio-refineries in chemical and pharmaceutical industries. Genome-scale modeling and simulations have been guided for metabolic engineering of Clostridium species for the production of organic solvents and organic acids. Among them, Clostridium sticklandii is one of the potential organisms to be exploited as a microbial cell factory for biofuel production. It is a hyper-ammonia producing bacterium and is able to catabolize amino acids as important carbon and energy sources via Stickland reactions and the development of the specific pathways...
December 2017: Biotechnology Reports
https://www.readbyqxmd.com/read/29155329/cloning-and-characterization-of-two-novel-%C3%AE-glucosidase-genes-encoding-isoenzymes-of-the-cellobiase-complex-from-cellulomonas-biazotea
#19
Anthony K N Chan, Alan K L Ng, Kate K Y Ng, W K R Wong
Enzymatic degradation of cellulosic waste to generate renewable biofuels has offered an attractive solution to the energy problem. Synergistic hydrolysis of cellulose residues requires the participation of three different types of cellulases - endoglucanases, exoglucanases, and β-glucosidases (Bgl). Our group has been interested in using Bgl of Cellulomonas biazotea in studies designed to investigate cooperative action among different cellulases. We previously have cloned bgl genes encoding Cba and Cba3, which are C...
November 16, 2017: Gene
https://www.readbyqxmd.com/read/29153160/a-100-year-review-calf-nutrition-and-management
#20
A F Kertz, T M Hill, J D Quigley, A J Heinrichs, J G Linn, J K Drackley
The first calf paper, published in the May 1919 issue of the Journal of Dairy Science (JDS), described factors affecting birth body weight of different breeds of calves. Other studies were done on nonmilk ingredients, growth charts were developed, and early weaning was followed to conserve milk fed to calves. Calf papers did not report use of statistics to control or record variation or to determine whether treatment means were different. Many experiments were more observational than comparative. Typically fewer than 5 calves, and sometimes 1 or 2 calves, were used per treatment...
December 2017: Journal of Dairy Science
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