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Protein energy wasting

Su Hui Seong, Anupom Roy, Hyun Ah Jung, Hee Jin Jung, Jae Sue Choi
ETHNOPHARMACOLOGICAL RELEVANCE: Pueraria lobata root was used to treat wasting-thirst regarded as diabetes mellitus and was included in the composition of Okcheonsan, which is prescribed for thirst-waste in traditional Chinese medicine. AIM OF THE STUDY: The objective of this study was to evaluate the anti-diabetic potential of the root of Pueraria lobata and its constituents via protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase inhibitory activities. MATERIALS AND METHODS: In this study, anti-diabetic activities of the 70% ethanolic (EtOH) extract from P...
October 18, 2016: Journal of Ethnopharmacology
Céline Pasian, Raymond Azar, Denis Fouque
Protein energy wasting (PEW) is an independent factor associated with morbi-mortality in chronic kidney disease. Wasting is particularly common in chronic diseases of organs such as kidney disease with a major impact at the stage of dialysis. It covers 20 to 70% of patients diagnosed with chronic kidney disease according to the degree of evolution of the disease and the diagnostic method used patients. Mechanisms of PEW are based mainly on anorexia and metabolic abnormalities caused by kidney disease. Nutritional treatment differs depending on the stage of the kidney disease acute or chronic treated whether or not by dialysis...
October 17, 2016: Néphrologie & Thérapeutique
Mengjing Wang, Jason Chou, Yongen Chang, Wei L Lau, Uttam Reddy, Connie M Rhee, Jing Chen, Chuanming Hao, Kamyar Kalantar-Zadeh
In the management of patients with chronic kidney diseases (CKD), a low-protein diet usually refers to a diet with protein intake of 0.6 to 0.8 grams per kilogram of body weight per day (g/kg/day) and should include at least 50% high-biologic-value protein. It may be supplemented with essential acids or nitrogen- free ketoanalogues if <0.6 g/kg/d. Low-protein diet can reduce proteinuria especially in non-diabetic CKD patients. In hypoalbuminemic patients it may lead to an increase in serum albumin level...
October 19, 2016: Panminerva Medica
Mar Ruperto, Guillermina Barril, Francisco J Sánchez-Muniz
Abdominal fat has been recognized as the most hormonally active tissue secreting a variety of adipocytokines and, therefore, potentially contributing to inflammation. The conicity index (Cindex) has been considered a valuable indicator of central obesity. This study aims to relate plasma concentrations of leptin, adiponectin, interleukin-6 (IL-6), and serum C-reactive protein (CRP) with Cindex values in hemodialysis (HD) patients. Cross-sectional study in 45 HD patients (55.6 % men; DM 20 %; mean age, 68...
October 13, 2016: Journal of Physiology and Biochemistry
Young Youl Hyun, Kyu-Beck Lee, Kook-Hwan Oh, Curie Ahn, Sue Kyung Park, Dong Wan Chae, Tae-Hyun Yoo, Kyu Hun Cho, Yong-Soo Kim, Young-Hwan Hwang
OBJECTIVE: Adiponectin (ADPN) has antiatherogenic, anti-inflammatory, and insulin-sensitizing effects. Serum ADPN levels are increased in patients with chronic kidney diseases (CKD), and higher ADPN is paradoxically a predictor of mortality in these patients. The aim of this study was to determine the association between serum ADPN levels and protein-energy wasting (PEW) in predialysis CKD. METHOD: We examined serum ADPN concentrations and PEW in 1303 patients from the KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease) study...
July 30, 2016: Nutrition
Seoyoung Jeon, Keun-Nam Sohn, Seongwon Seo
BACKGROUND: By-products of pickled radish (BPR) are considered food waste. Approximately 300 g/kg of the total mass of raw materials becomes BPR. Production of pickled radish has grown continuously and is presently about 40,000 metric tons annually in Korea. The objective of the present study was thus to explore the possibility of using BPR as a ruminant feed ingredient. RESULTS: BPR contained a large amount of moisture (more than 800 g/kg) and ash, and comprised mostly sodium (103 g/kg DM) and chloride (142 g/kg DM)...
2016: Journal of Animal Science and Technology
Connie M Rhee, Amy S You, Tara Koontz Parsons, Amanda R Tortorici, Rachelle Bross, David E St-Jules, Jennie Jing, Martin L Lee, Debbie Benner, Csaba P Kovesdy, Rajnish Mehrotra, Joel D Kopple, Kamyar Kalantar-Zadeh
BACKGROUND: Inadequate protein intake and hypoalbuminemia, indicators of protein-energy wasting, are among the strongest mortality predictors in hemodialysis patients. Hemodialysis patients are frequently counseled on dietary phosphorus restriction, which may inadvertently lead to decreased protein intake. We hypothesized that, in hypoalbuminemic hemodialysis patients, provision of high-protein meals during hemodialysis combined with a potent phosphorus binder increases serum albumin without raising phosphorus levels...
September 22, 2016: Nephrology, Dialysis, Transplantation
Li Xu, Hao Ren, Guangang Gao, Linkang Zhou, Muhammad Arshad Malik, Peng Li
Metabolism refers to a chain of chemical reactions converting food/fuel into energy to conduct cellular processes, including the synthesis of the building blocks of the body, such as proteins, lipids, nucleic acids, and carbohydrates, and the elimination of nitrogenous wastes. Metabolic chain reactions are catalyzed by various enzymes that are orchestrated in specific pathways. Metabolic pathways are important for organisms to grow and reproduce, maintain their structures, and respond to their environments...
September 20, 2016: IUBMB Life
Juliane Schmidt, Ren Wei, Thorsten Oeser, Matheus Regis Belisário-Ferrari, Markus Barth, Johannes Then, Wolfgang Zimmermann
The enzymatic degradation of polyethylene terephthalate (PET) occurs at mild reaction conditions and may find applications in environmentally friendly plastic waste recycling processes. The hydrolytic activity of the homologous polyester hydrolases LC cutinase (LCC) from a compost metagenome and TfCut2 from Thermobifida fusca KW3 against PET films was strongly influenced by the reaction medium buffers tris(hydroxymethyl)aminomethane (Tris), 3-(N-morpholino)propanesulfonic acid (MOPS), and sodium phosphate. LCC showed the highest initial hydrolysis rate of PET films in 0...
September 2016: FEBS Open Bio
Anastasia Markaki, Maria G Grammatikopoulou, Maria Venihaki, John Kyriazis, Kostas Perakis, Kostas Stylianou
OBJECTIVE: The aim of the study was to examine the prevalence of protein-energy wasting (PEW) in hemodialysis (HD) and peritoneal dialysis (PD) patients in our center and determine whether adiponectin and leptin are involved in the development of PEW. DESIGN: Prospective (18 months). SETTING: University Hospital of Heraklion, Crete, Greece. SUBJECTS: Seventy-four end-stage-renal-disease patients, 47 on HD and 27 on PD...
November 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
R Rajabi, R Tahmasbi, O Dayani, A Khezri
This study was conducted to evaluate the effect of feeding ensiled alfalfa with waste date on ruminal fermentation characteristics, microbial protein synthesis, protozoa population and blood parameters in sheep. Eight rams were used in a 2 × 2 change over design. Each experimental period consisted of 21 days including 16 days for adaptation and 5 days for sampling. For ensiling, fresh alfalfa (Medicago sativa L.) with different levels of waste date (Phoenix dactylifera L.) were mixed together and ensiled in 100-l containers for 45 days...
September 7, 2016: Journal of Animal Physiology and Animal Nutrition
Hideaki Shibata, James N Galloway, Allison M Leach, Lia R Cattaneo, Laura Cattell Noll, Jan Willem Erisman, Baojing Gu, Xia Liang, Kentaro Hayashi, Lin Ma, Tommy Dalgaard, Morten Graversgaard, Deli Chen, Keisuke Nansai, Junko Shindo, Kazuyo Matsubae, Azusa Oita, Ming-Chien Su, Shin-Ichiro Mishima, Albert Bleeker
Nitrogen (N) management presents a sustainability dilemma: N is strongly linked to energy and food production, but excess reactive N causes environmental pollution. The N footprint is an indicator that quantifies reactive N losses to the environment from consumption and production of food and the use of energy. The average per capita N footprint (calculated using the N-Calculator methodology) of ten countries varies from 15 to 47 kg N capita(-1) year(-1). The major cause of the difference is the protein consumption rates and food production N losses...
September 6, 2016: Ambio
Ana Rita Gaia Machado, Maria Francisca Simas Teixeira, Larissa de Souza Kirsch, Maria da Conceição Loureiro Campelo, Ila Maria de Aguiar Oliveira
This paper examined the growth and yield performance of Lentinus citrinus on cupuaçu exocarp (Theobroma grandiflorum) mixed with litter (CE + LI) or rice bran (Oryza sativa) (CE + RB) in the ratio of 2:1 (800 g:200 g) to investigate the nutritional composition and proteolytic potential of the fruiting body produced. Significance values of yield were determined on substrate combinations. In CE + LI the biological efficiency of the mushrooms was 93.5% and the content of fat (4.5%), fiber (11.0%), protein (27...
September 2016: Saudi Journal of Biological Sciences
Sebastian Schwede, Eva Thorin, Johan Lindmark, Patrik Klintenberg, Ari Jääskeläinen, Anssi Suhonen, Reino Laatikainen, Elias Hakalehto
A novel biorefinery concept was piloted using protein-rich slaughterhouse waste, chicken manure and straw as feedstocks. The basic idea was to provide a proof of concept for the production of platform chemicals and biofuels from organic waste materials at non-septic conditions. The desired biochemical routes were 2,3-butanediol and acetone-butanol fermentation. The results showed that hydrolysis resulted only in low amounts of easy degradable carbohydrates. However, amino acids released from the protein-rich slaughterhouse waste were utilized and fermented by the bacteria in the process...
August 30, 2016: Environmental Technology
Maria Rohm, Michaela Schäfer, Victor Laurent, Bilgen Ekim Üstünel, Katharina Niopek, Carolyn Algire, Oksana Hautzinger, Tjeerd P Sijmonsma, Annika Zota, Dasa Medrikova, Natalia S Pellegata, Mikael Ryden, Agné Kulyte, Ingrid Dahlman, Peter Arner, Natasa Petrovic, Barbara Cannon, Ez-Zoubir Amri, Bruce E Kemp, Gregory R Steinberg, Petra Janovska, Jan Kopecky, Christian Wolfrum, Matthias Blüher, Mauricio Berriel Diaz, Stephan Herzig
Cachexia represents a fatal energy-wasting syndrome in a large number of patients with cancer that mostly results in a pathological loss of skeletal muscle and adipose tissue. Here we show that tumor cell exposure and tumor growth in mice triggered a futile energy-wasting cycle in cultured white adipocytes and white adipose tissue (WAT), respectively. Although uncoupling protein 1 (Ucp1)-dependent thermogenesis was dispensable for tumor-induced body wasting, WAT from cachectic mice and tumor-cell-supernatant-treated adipocytes were consistently characterized by the simultaneous induction of both lipolytic and lipogenic pathways...
October 2016: Nature Medicine
Amalie T Levy, Kelvin H Lee, Thomas E Hanson
: Microbial sulfur metabolism, particularly the formation and consumption of insoluble elemental sulfur (S(0)), is an important biogeochemical engine that has been harnessed for applications ranging from bioleaching and biomining to remediation of waste streams. Chlorobaculum tepidum, a low-light-adapted photoautolithotrophic sulfur-oxidizing bacterium, oxidizes multiple sulfur species and displays a preference for more reduced electron donors: sulfide > S(0) > thiosulfate. To understand this preference in the context of light energy availability, an "energy landscape" of phototrophic sulfur oxidation was constructed by varying electron donor identity, light flux, and culture duration...
November 1, 2016: Applied and Environmental Microbiology
A Noce, M F Vidiri, G Marrone, E Moriconi, A Bocedi, A Capria, V Rovella, G Ricci, A De Lorenzo, N Di Daniele
Chronic kidney disease (CKD) is becoming increasingly widespread in the world. Slowing its progression means to prevent uremic complications and improve quality of life of patients. Currently, a low-protein diet (LPD) is one of the tools most used in renal conservative therapy but a possible risk connected to LPD is protein-energy wasting. The aim of this study is evaluate the possible correlation between LPD and malnutrition onset. We enrolled 41 CKD patients, stages IIIb/IV according to K-DIGO guidelines, who followed for 6 weeks a diet with controlled protein intake (recommended dietary allowance 0...
2016: Cell Death Discovery
Yu-Lian Huang, Li Tan, Ting-Ting Wang, Zhao-Yong Sun, Yue-Qin Tang, Kenji Kida
Thermophilic dry methane fermentation is advantageous for feedstock with high solid content. Distillation residue with 65.1 % moisture content was eluted from ethanol fermentation of kitchen waste and subjected to thermophilic dry methane fermentation, after adjusting the moisture content to 75 %. The effect of carbon to nitrogen (C/N) ratio on thermophilic dry methane fermentation was investigated. Results showed that thermophilic dry methane fermentation could not be stably performed for >10 weeks at a C/N ratio of 12...
August 15, 2016: Applied Biochemistry and Biotechnology
Masakazu Saitoh, Masumi Ogawa, Marcelo Rodrigues Dos Santos, Hisae Kondo, Kiichi Suga, Haruki Itoh, Yoichiro Tabata
Patients under hemodialysis present protein-energy wasting (PEW), which is related with higher mortality rates. The study aimed to determine whether intradialytic resistance exercise training could improve physical performance, physical activity, and PEW in hemodialysis patients. In single center study, 75 hemodialysis patients were enrolled in an intradialytic resistance exercise training consisting of 20 min of adapted leg press, with a gymnastic ball, 3 days/week, during 9 months on the same day of hemodialysis therapy...
August 15, 2016: Therapeutic Apheresis and Dialysis
Geovana Martin-Alemañy, Rafael Valdez-Ortiz, Guadalupe Olvera-Soto, Irma Gomez-Guerrero, Guillermo Aguire-Esquivel, Guillermo Cantu-Quintanilla, Juan Carlos Lopez-Alvarenga, Paola Miranda-Alatriste, Angeles Espinosa-Cuevas
BACKGROUND: Protein-energy wasting (PEW) is common in patients undergoing hemodialysis (HD). Studies have assessed the positive effect of oral nutritional supplementation (ONS) or resistance exercise (RE) on nutritional status (NS) markers in patients undergoing HD. METHODS: The aim of this study was to assess the effect of ONS and RE on NS and the quality of life (QOL) of 36 patients undergoing HD. In a randomized clinical trial, patients were divided into the following two groups: a control group (ONS) that received a can of ONS during their HD sessions and an intervention group (ONS + RE) that received a can of ONS and underwent a 40-min session of RE during their HD sessions...
October 2016: Nephrology, Dialysis, Transplantation
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