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https://www.readbyqxmd.com/read/28721542/molecular-characterization-modeling-in-silico-analysis-of-equine-pituitary-gonadotropin-alpha-subunit-and-docking-interaction-studies-with-ganirelix
#1
Anuradha Bhardwaj, Varij Nayan, Parvati Sharma, Sanjay Kumar, Yash Pal, Jitender Singh
Equine pituitary gonadotropins (eLH, eFSH, eCG) are heterodimeric glycoprotein hormones with alpha (α) and beta (β) subunits. It is responsible for maintenance of pregnancy in mares during early gestation and fairly valuable for inducing superovulation in animals other than equines. The alpha subunit is common, while beta subunit is species-specific in all glycoprotein hormones. In the present investigation, molecular cloning and in silico characterization including homology modeling and molecular docking analysis of the equine chorionic gonadotropin (eCG) alpha subunit was carried out for gaining structural and functional insights into the eCG alpha subunit and its possible interaction with ganirelix, a gonadotropin-releasing hormone (GnRH) antagonist...
December 2016: In Silico Pharmacology
https://www.readbyqxmd.com/read/28667190/3-lead-electrocardiogram-is-more-reliable-than-pulse-oximetry-to-detect-bradycardia-during-stabilisation-at-birth-of-very-preterm-infants
#2
Beatriz Iglesias, Marí A José Rodrí Guez, Esther Aleo, Enrique Criado, Jose Martí Nez-Orgado, Luis Arruza
OBJECTIVES: Current neonatal resuscitation guidelines suggest the use of ECG in the delivery room (DR) to assess heart rate (HR). However, reliability of ECG compared with pulse oximetry (PO) in a situation of bradycardia has not been specifically investigated. The objective of the present study was to compare HR monitoring using ECG or PO in a situation of bradycardia (HR <100 beats per minute (bpm)) during preterm stabilisation in the DR. STUDY DESIGN: Video recordings of resuscitations of infants <32 weeks of gestation were reviewed...
June 30, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28646403/routine-ct-angiography-to-detect-severe-coronary-artery-disease-prior-to-transcatheter-aortic-valve-replacement
#3
S Chava, G Gentchos, A Abernethy, B Leavitt, E Terrien, H L Dauerman
Patients undergoing TAVR undergo routine CT angiography (CTA) to assess aorto-iliac pathology and annular dimensions. While coronary CTA may exclude severe CAD in younger patients, its efficacy in defining CAD severity prior to TAVR may be limited. We retrospectively studied 50 consecutive patients undergoing both invasive coronary angiography (ICA) and routine pre-TAVR CTA. Severe CAD was defined as ≥50% stenosis by quantitative coronary angiography and compared to a blinded CTA visual estimation of ≥50% stenosis...
August 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28644157/ecg-case-of-the-month-chest-pain-and-ecg-abnormalities
#4
D Luke Glancy
A 27-year-old man was admitted to the coronary care unit because of chest pain and an electrocardiogram (ECG) read by the computer as an inferior infarct and left ventricular hypertrophy (Figure).
May 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28628659/wave-intensity-of-aortic-root-pressure-as-diagnostic-marker-of-left-ventricular-systolic-dysfunction
#5
Bernhard Hametner, Stephanie Parragh, Thomas Weber, Siegfried Wassertheurer
BACKGROUND: Systolic left ventricular function strongly influences the blood pressure waveform. Therefore, pressure-derived parameters might potentially be used as non-invasive, diagnostic markers of left ventricular impairment. The aim of this study was to investigate the performance of pressure-based parameters in combination with electrocardiography (ECG) for the detection of left ventricular systolic dysfunction defined as severely reduced ejection fraction (EF). METHODS AND RESULTS: Two populations, each comprising patients with reduced EF and pressure-matched controls, were included for the main analysis (51/102 patients) and model testing (44/88 patients)...
2017: PloS One
https://www.readbyqxmd.com/read/28607679/proper-electronic-order-linkage-of-electrocardiograms-at-a-large-children-s-hospital-improves-reporting-and-revenue
#6
David S Spar, Wayne A Mays, David S Cooper, Lucille Sullivan, Terra Hicks, Jeffrey B Anderson
Electrocardiograms (ECGs) are performed to determine an individual's cardiac rhythm. Approximately 25,000 ECGs are performed yearly throughout our hospital system. Historically only 68% of all ECGs were performed with the proper order linked to the electronic ECG reading system (MUSE). Failure to link the orders to the electronic reading system leads to problems in patient safety, reporting and hospital revenue. Our aim was to increase the percentage of linked ECG orders in MUSE compared to total ECGs performed from 68% to 95%...
2017: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/28501559/fast-accurate-and-easy-to-teach-qt-interval-assessment-the-triplicate-concatenation-method
#7
Valentin Saqué, Martino Vaglio, Christian Funck-Brentano, Maya Kilani, Olivier Bourron, Agnès Hartemann, Fabio Badilini, Joe-Elie Salem
BACKGROUND: The gold standard method for assessing the QTcF (QT corrected for heart rate by Fridericia's cube root formula) interval is the "QTcF semiautomated triplicate averaging method" (TAM), which consists of measuring three QTcF values semiautomatically, for each 10-second sequence of a triplicate electrocardiogram set, and averaging them to get a global and unique QTcF value. Thus, TAM is time consuming. We have developed a new method, namely the "QTcF semiautomated triplicate concatenation method" (TCM), which consists of concatenating the three 10-second sequences of the triplicate electrocardiogram set as if they were a single 30-second electrocardiogram, and measuring QTcF only once for the triplicate electrocardiogram set...
May 11, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28484122/effects-of-propranolol-and-verapamil-on-changes-in-tq-and-st-segment-potentials-during-graded-coronary-flow-reduction-in-a-porcine-myocardial-ischemia-model
#8
Ichiro Watanabe, Leonard S Gettes
Acute myocardial ischemia causes TQ depression and ST elevation. However, the effects of cardioprotective drugs such as β-blockers and Ca(++)-antagonists on the extent of TQ depression, ST elevation, and myocardial ischemic injury are not fully understood.We created a carotid-coronary shunt in 30 pigs, and extracellular K(+) ([K(+)]e), TQ, and ST segments were recorded simultaneously with K(+)-selective plunge electrodes placed in the left anterior descending artery (LAD) distribution during graded LAD flow reduction before and after administration of propranolol or verapamil...
May 8, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28479090/electrocardiogram-training-for-residents-a-curriculum-based-on-facebook-and-twitter
#9
Stanley S Liu, Sammy Zakaria, Dhananjay Vaidya, Mukta C Srivastava
BACKGROUND: We studied whether social media applications can serve as effective educational tools for teaching electrocardiogram (ECG) interpretation to medical residents. METHODS: 39 emergency, family, and internal medicine residents participated in the 33-week "ECG of the Week" curriculum via Facebook and Twitter. ECG skill was assessed before and after the study with a 10-ECG quiz. Outcomes of interest included predictors of participant response rates and post-study quiz performance...
April 22, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28460689/a-new-4-variable-formula-to-differentiate-normal-variant-st-segment-elevation-in-v2-v4-early-repolarization-from-subtle-left-anterior-descending-coronary-occlusion-adding-qrs-amplitude-of-v2-improves-the-model
#10
Brian E Driver, Ayesha Khalil, Timothy Henry, Faraz Kazmi, Amina Adil, Stephen W Smith
INTRODUCTION: Precordial normal variant ST elevation (NV-STE), previously often called "early repolarization," may be difficult to differentiate from subtle ischemic STE due to left anterior descending (LAD) occlusion. We previously derived and validated a logistic regression formula that was far superior to STE alone for differentiating the two entities on the ECG. The tool uses R-wave amplitude in lead V4 (RAV4), ST elevation at 60 ms after the J-point in lead V3 (STE60V3) and the computerized Bazett-corrected QT interval (QTc-B)...
April 19, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28386043/nongated-cardiac-computed-tomographic-angiograms-for-detection-of-embolic-sources-in-acute-ischemic-stroke
#11
Leonard L L Yeo, Staffan Holmin, Tommy Andersson, Erik Lundström, Anil Gopinathan, Er Luen Lim, Benjamin S H Leong, Win Sen Kuan, Eric Ting, Benjamin Y Q Tan, Sterling Ellis Eide, Edgar L K Tay
BACKGROUND AND PURPOSE: We assessed the feasibility of obtaining diagnostic quality images of the heart and thoracic aorta by extending the z axis coverage of a non-ECG-gated computed tomographic angiogram performed in the primary evaluation of acute stroke without increasing the contrast dose. METHODS: Twenty consecutive patients with acute ischemic stroke within the 4.5 hours of symptom onset were prospectively recruited. We increased the longitudinal coverage to the domes of the diaphragm to include the heart...
May 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28384912/assessment-of-autonomic-dysfunction-in-acute-stroke-patients-at-a-tertiary-care-hospital
#12
Hemachandrika Chidambaram, Kothai Gnanamoorthy, Prasanna Karthik Suthakaran, Kannan Rajendran, Chitrambalam Pavadai
INTRODUCTION: In patients who present with acute cerebro-vascular disease, autonomic function testing is usually not given its due importance. This is because of the complex nature of the autonomic function tests and the relative technical difficulty faced in administering the tests to the patients. A simple and non-invasive method to assess the autonomic dysfunction is measurement of resting Heart Rate Variability (HRV). AIM: To study the pattern of autonomic dysfunction among patients admitted with acute stroke and to study the relationship between autonomic dysfunction and the morbidity and mortality associated with acute stroke...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28342858/aqueous-extract-from-leaf-of-artocarpus-altilis-provides-cardio-protection-from-isoproterenol-induced-myocardial-damage-in-rats-negative-chronotropic-and-inotropic-effects
#13
Chukwuemeka Nwokocha, Javier Palacios, Mario J Simirgiotis, Jemesha Thomas, Magdalene Nwokocha, Lauriann Young, Rory Thompson, Fredi Cifuentes, Adrian Paredes, Rupika Delgoda
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Artocarpus altilis (Parkinson ex F.A.Zorn, Fosberg) (Moraceae) are used in the management of hypertension; this study assessed the cardio-protective effects of the leaf extract on isoproterenol (ISO) induced myocardial damage in rats. MATERIAL AND METHODS: Twenty (20) adult male Sprague-Dawley rats (175-230g) were divided into 5 groups. Group 1 (Control), 2 (AA) received 50mg/Kg Artocarpus altilis (AA) only; 3 (ISO) received 85mg/Kg ISO only; 4 (ISO+AA/50) and 5 (ISO+AA/100) received 50 and 100mg/Kg AA respectively for 6 days, after induced with ISO twice (85mg/Kg) at a 24-h period...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28318817/clinical-and-mutational-characteristics-of-duchenne-muscular-dystrophy-patients-based-on-a-comprehensive-database-in-south-china
#14
Dan-Ni Wang, Zhi-Qiang Wang, Lei Yan, Jin He, Min-Ting Lin, Wan-Jin Chen, Ning Wang
The development of clinical trials for Duchenne muscular dystrophy (DMD) in China faces many challenges due to limited information about epidemiological data, natural history and clinical management. To provide these detailed data, we developed a comprehensive database based on registered DMD patients from South China and analysed their clinical and mutational characteristics. The database included DMD registrants confirmed by clinical presentation, family history, genetic detection, prognostic outcome, and/or muscle biopsy...
February 21, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28269566/dual-modality-arterial-pulse-monitoring-system-for-continuous-blood-pressure-measurement
#15
Wen-Xuan Dai, Yuan-Ting Zhang, Jing Liu, Xiao-Rong Ding, Ni Zhao
Accurate and ambulatory measurement of blood pressure (BP) is essential for efficient diagnosis, management and prevention of cardiovascular diseases (CVDs). However, traditional cuff-based BP measurement methods provide only intermittent BP readings and can cause discomfort with the occlusive cuff. Although pulse transit time (PTT) method is promising for cuffless and continuous BP measurement, its pervasive use is restricted by its limited accuracy and requirement of placing sensors on multiple body sites...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268382/portable-electrocardiogram-device-using-android-smartphone
#16
S G E Brucal, G K D Clamor, L A O Pasiliao, J P F Soriano, L P M Varilla
Portable electrocardiogram (ECG) capturing device can be interfaced to a smart phone installed with an android-based application (app). This app processes and analyses the data sent by the device to provide an interpretation of the patient/user's heart current condition (e.g.: beats per minute, heart signal waveform, R-R interval). The ECG recorded by the app is stored in the smart phone's Secure Digital (SD) card and cloud storage which can be accessed remotely by a physician to aid in providing medical diagnosis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267477/comparison-of-diagnostic-value-using-a-small-single-channel-p-wave-centric-sternal-ecg-monitoring-patch-with-a-standard-3-lead-holter-system-over-24-hours
#17
COMPARATIVE STUDY
Warren M Smith, Fiona Riddell, Morag Madon, Marye J Gleva
BACKGROUND: To compare simultaneous recordings from an external patch system specifically designed to ensure better P-wave recordings and standard Holter monitor to determine diagnostic efficacy. Holter monitors are a mainstay of clinical practice, but are cumbersome to access and wear and P-wave signal quality is frequently inadequate. METHODS: This study compared the diagnostic efficacy of the P-wave centric electrocardiogram (ECG) patch (Carnation Ambulatory Monitor) to standard 3-channel (leads V1, II, and V5) Holter monitor (Northeast Monitoring, Maynard, MA)...
March 2017: American Heart Journal
https://www.readbyqxmd.com/read/28243683/effect-of-alectinib-on-cardiac-electrophysiology-results-from-intensive-electrocardiogram-monitoring-from-the-pivotal-phase-ii-np28761-and-np28673-studies
#18
MULTICENTER STUDY
Peter N Morcos, Katrijn Bogman, Stanislas Hubeaux, Carolina Sturm-Pellanda, Thorsten Ruf, Walter Bordogna, Sophie Golding, Ali Zeaiter, Markus Abt, Bogdana Balas
PURPOSE: Alectinib, a central nervous system (CNS)-active ALK inhibitor, has demonstrated efficacy and safety in ALK+ non-small-cell lung cancer that has progressed following crizotinib treatment. Other ALK inhibitors have shown concentration-dependent QTc prolongation and treatment-related bradycardia. Therefore, this analysis evaluated alectinib safety in terms of electrophysiologic parameters. METHODS: Intensive triplicate centrally read electrocardiogram (ECG) and matched pharmacokinetic data were collected across two alectinib single-arm trials...
March 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28227821/dual-modality-arterial-pulse-monitoring-system-for-continuous-blood-pressure-measurement
#19
Wen-Xuan Dai, Yuan-Ting Zhang, Jing Liu, Xiao-Rong Ding, Ni Zhao, Wen-Xuan Dai, Yuan-Ting Zhang, Jing Liu, Xiao-Rong Ding, Ni Zhao, Wen-Xuan Dai, Yuan-Ting Zhang, Xiao-Rong Ding, Ni Zhao, Jing Liu
Accurate and ambulatory measurement of blood pressure (BP) is essential for efficient diagnosis, management and prevention of cardiovascular diseases (CVDs). However, traditional cuff-based BP measurement methods provide only intermittent BP readings and can cause discomfort with the occlusive cuff. Although pulse transit time (PTT) method is promising for cuffless and continuous BP measurement, its pervasive use is restricted by its limited accuracy and requirement of placing sensors on multiple body sites...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226547/portable-electrocardiogram-device-using-android-smartphone
#20
S G E Brucal, G K D Clamor, L A O Pasiliao, J P F Soriano, L P M Varilla, S G E Brucal, G K D Clamor, L A O Pasiliao, J P F Soriano, L P M Varilla, J P F Soriano, L P M Varilla, S G E Brucal, L A O Pasiliao, G K D Clamor
Portable electrocardiogram (ECG) capturing device can be interfaced to a smart phone installed with an android-based application (app). This app processes and analyses the data sent by the device to provide an interpretation of the patient/user's heart current condition (e.g.: beats per minute, heart signal waveform, R-R interval). The ECG recorded by the app is stored in the smart phone's Secure Digital (SD) card and cloud storage which can be accessed remotely by a physician to aid in providing medical diagnosis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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