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https://www.readbyqxmd.com/read/29775674/the-prognostic-value-of-the-frontal-qrs-t-angle-is-comparable-to-cardiovascular-autonomic-neuropathy-regarding-long-term-mortality-in-people-with-diabetes-a-population-based-study
#1
O May, C B Graversen, M Ø Johansen, H Arildsen
Cardiovascular autonomic neuropathy (CAN) is a well known prognostic marker in diabetes. A large angle between the QRS- and the T-wave vector (QRS-T angle) in the electrocardiogram (ECG) has recently been introduced as another marker of poor prognosis. AIM: To assess and compare the long-term predictive power of the frontal plane QRS-T angle with CAN in people with diabetes. METHODS: In 1992-93 people with diabetes in the municipality of Horsens, Denmark, were identified by the prescription method andan age and gender stratified sample of 240 individuals with diabetes were randomly selected...
May 15, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29755409/glial-cells-missing-1-regulates-equine-chorionic-gonadotrophin-beta-subunit-via-binding-to-the-proximal-promoter
#2
Jordan E Read, Victoria Cabrera-Sharp, Phoebe Kitscha, Judith E Cartwright, Peter J King, Robert C Fowkes, Amanda M de Mestre
Equine chorionic gonadotrophin (eCG) is a placental glycoprotein critical for early equine pregnancy and used therapeutically in a number of species to support reproductive activity. The factors in trophoblast that transcriptionally regulate eCGβ-subunit ( LHB ), the gene which confers the hormones specificity for the receptor, are not known. The aim of this study was to determine if glial cells missing 1 regulates LHB promoter activity. Here, studies of the LHB proximal promoter identified four binding sites for glial cells missing 1 (GCM1) and western blot analysis confirmed GCM1 was expressed in equine chorionic girdle (ChG) and surrounding tissues...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29735633/atrial-fibrillation-detection-during-24-hour-ambulatory-blood-pressure-monitoring-comparison-with-24-hour-electrocardiography
#3
Anastasios Kollias, Antonios Destounis, Petros Kalogeropoulos, Konstantinos G Kyriakoulis, Angeliki Ntineri, George S Stergiou
This study assessed the diagnostic accuracy of a novel 24-hour ambulatory blood pressure (ABP) monitor (Microlife WatchBP O3 Afib) with implemented algorithm for automated atrial fibrillation (AF) detection during each ABP measurement. One hundred subjects (mean age 70.6±8.2 [SD] years; men 53%; hypertensives 85%; 17 with permanent AF; 4 paroxysmal AF; and 79 non-AF) had simultaneous 24-hour ABP monitoring and 24-hour Holter monitoring. Among a total of 6410 valid ABP readings, 1091 (17%) were taken in ECG AF rhythm...
May 7, 2018: Hypertension
https://www.readbyqxmd.com/read/29651595/heart-rate-variability-for-rapid-risk-stratification-of-emergency-patients-with-malignant-disease
#4
K Boehm, M Duckheim, L Mizera, P Groga-Bada, N Malek, F Kreth, M Gawaz, C S Zuern, C Eick
INTRODUCTION: Neoplasms are the second most common diseases in western countries. Many patients with malignant diseases repeatedly present themselves in the emergency department (ED). Due to limited capacities, appropriate risk stratification strategies for cancer patients have to be developed. This study assesses if deceleration capacity (DC) of heart rate as a parameter of heart rate variability predicts mortality in emergency patients with malignant diseases. METHODS: Prospectively, 140 adults with different entities of malignant diseases who presented in the medical ED were included...
April 12, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29622592/contact-free-screening-of-atrial-fibrillation-by-a-smartphone-using-facial-pulsatile-photoplethysmographic-signals
#5
Bryan P Yan, William H S Lai, Christy K Y Chan, Stephen Chun-Hin Chan, Lok-Hei Chan, Ka-Ming Lam, Ho-Wang Lau, Chak-Ming Ng, Lok-Yin Tai, Kin-Wai Yip, Olivia T L To, Ben Freedman, Yukkee C Poh, Ming-Zher Poh
BACKGROUND: We aimed to evaluate a novel method of atrial fibrillation (AF) screening using an iPhone camera to detect and analyze photoplethysmographic signals from the face without physical contact by extracting subtle beat-to-beat variations of skin color that reflect the cardiac pulsatile signal. METHODS AND RESULTS: Patients admitted to the cardiology ward of the hospital for clinical reasons were recruited. Simultaneous facial and fingertip photoplethysmographic measurements were obtained from 217 hospital inpatients (mean age, 70...
April 5, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29535065/automated-atrial-fibrillation-detection-algorithm-using-smartwatch-technology
#6
Joseph M Bumgarner, Cameron T Lambert, Ayman A Hussein, Daniel J Cantillon, Bryan Baranowski, Kathy Wolski, Bruce D Lindsay, Oussama M Wazni, Khaldoun G Tarakji
BACKGROUND: The Kardia Band (KB) is a novel technology that enables patients to record a rhythm strip using an Apple smartwatch. The band is paired with an app providing automated detection of atrial fibrillation (AF). OBJECTIVES: To examine whether the KB could accurately differentiate sinus rhythm (SR) from AF compared to physician-interpreted 12-lead ECGs and KB recordings. METHODS: Consecutive patients with AF presenting for cardioversion (CV) were enrolled...
March 7, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29525063/diagnostic-accuracy-of-a-novel-mobile-phone-application-for-the-detection-and-monitoring-of-atrial-fibrillation
#7
Guy Rozen, Jeena Vaid, Seyed Mohammadreza Hosseini, M Ihsan Kaadan, Allon Rafael, Attila Roka, Yukkee C Poh, Ming-Zher Poh, Edwin Kevin Heist, Jeremy Neil Ruskin
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in adults, associated with significant morbidity, increased mortality, and rising health-care costs. Simple and available tools for the accurate detection of arrhythmia recurrence in patients after electrical cardioversion (CV) or ablation procedures for AF can help to guide therapeutic decisions. We conducted a prospective, single-center study to evaluate the accuracy of Cardiio Rhythm Mobile Application (CRMA) for AF detection. Patients >18 years of age who were scheduled for elective CV for AF were enrolled in the study...
May 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29512019/an-external-validation-of-the-heart-pathway-among-emergency-department-patients-with-chest-pain
#8
Joshua James Oliver, Matthew Jay Streitz, Jessica Marie Hyams, Richard Michael Wood, Yevgeniy Mikhaylovich Maksimenko, Brit Long, Robert Michael Barnwell, Michael David April
The impact of an outpatient disposition strategy for patients with HEART score 0-3 (HEART pathway) on HEART score prognostic accuracy is unclear. Our objective is to perform an external validation the HEART score in the setting of recent implementation of the HEART pathway. We conducted an external validation study of the HEART pathway among patients presenting to our ED with chest pain 6 weeks after institutional implementation of a HEART pathway outpatient disposition pathway. We reviewed the charts of 625 consecutive patients with chest pain...
March 6, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29440183/ambulatory-blood-pressure-and-long-term-risk-for-atrial-fibrillation
#9
Valérie Tikhonoff, Tatiana Kuznetsova, Lutgarde Thijs, Nicholas Cauwenberghs, Katarzyna Stolarz-Skrzypek, Jitka Seidlerová, Sofia Malyutina, Natasza Gilis-Malinowska, Ewa Swierblewska, Kalina Kawecka-Jaszcz, Jan Filipovský, Krzysztof Narkiewicz, Gregory Y H Lip, Edoardo Casiglia, Jan A Staessen
OBJECTIVE: Data on the contribution of ambulatory blood pressure (ABP) components to the risk of developing atrial fibrillation (AF) are limited. We prospectively tested the hypothesis that ABP may represent a potentially modifiable risk factor for the development of AF in a European population study. METHODS: We recorded daytime blood pressure (BP) in 3956 subjects randomly recruited from the general population in five European countries. Of these participants, 2776 (70...
February 9, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29204719/correction-to-electrocardiogram-based-predictors-for-arrhythmia-after-spinal-cord-injury
#10
H J C Ravensbergen, M L Walsh, A V Krassioukov, V E Claydon
There is a typographical error in the formula presented for QTVI. While the formula was correctly applied to the data presented, the description of the formula has an incorrectly placed parenthesis. It should read.
February 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29197025/german-cardiac-ct-registry-indications-procedural-data-and-clinical-consequences-in-7061-patients-undergoing-cardiac-computed-tomography
#11
Mohamed Marwan, Stephan Achenbach, Grigorios Korosoglou, Axel Schmermund, Steffen Schneider, Oliver Bruder, Jörg Hausleiter, Stephen Schroeder, Sebastian Barth, Sebastian Kerber, Alexander Leber, Werner Moshage, Jochen Senges
Cardiac computed tomography permits quantification of coronary calcification as well as detection of coronary artery stenoses after contrast enhancement. Moreover, cardiac CT offers high-resolution morphologic and functional imaging of cardiac structures which is valuable for various structural heart disease interventions and electrophysiology procedures. So far, only limited data exist regarding the spectrum of indications, image acquisition parameters as well as results and clinical consequences of cardiac CT examinations using state-of-the-art CT systems in experienced centers...
December 1, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29189666/validity-of-wearable-activity-monitors-during-cycling-and-resistance-exercise
#12
Benjamin D Boudreaux, Edward P Hebert, Daniel B Hollander, Brian M Williams, Corinne L Cormier, Mildred R Naquin, Wynn W Gillan, Emily E Gusew, Robert R Kraemer
INTRODUCTION: The use of wearable activity monitors has seen rapid growth; however, the mode and intensity of exercise could affect the validity of heart rate (HR) and caloric (energy) expenditure (EE) readings. There is a lack of data regarding the validity of wearable activity monitors during graded cycling regimen and a standard resistance exercise. The present study determined the validity of eight monitors for HR compared with an ECG and seven monitors for EE compared with a metabolic analyzer during graded cycling and resistance exercise...
March 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29174250/assessment-of-right-ventriclular-systolic-function-prior-to-cardiac-resynchronization-therapy-does-it-make-any-difference
#13
Mohamed A Abdelhamid, Mazen T Ghanem, Ayman M Abdelmotaleb
BACKGROUND: Cardiac resynchronization therapy (CRT) is an effective treatment for patients with advanced heart failure (HF). Nearly 30% of candidates are inadequate responders. The benefit of patients with right sided heart failure from CRT is still a matter of debate. We examined the effect of CRT on right ventricular (RV) dimensions and overall systolic function and whether RV function prior to CRT could have an impact on CRT response. METHODS: 94 patients with a mean age of 53...
November 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29174099/smartphone-ecg-for-evaluation-of-st-segment-elevation-myocardial-infarction-stemi-design-of-the-st-leuis-international-multicenter-study
#14
Alejandro Barbagelata, Charles F Bethea, Harry W Severance, Robert J Mentz, David Albert, Gregory W Barsness, Viet T Le, Jeffrey L Anderson, T Jared Bunch, Frank Yanowitz, Benjamin Chisum, Brianna S Ronnow, Joseph B Muhlestein
In patients experiencing an ST-elevation myocardial infarction (STEMI), rapid diagnosis and immediate access to reperfusion therapy leads to optimal clinical outcomes. The rate-limiting step in STEMI diagnosis is the availability and performance of a 12-lead ECG. Recent technology has provided access to a reliable means of obtaining an ECG reading through a smartphone application (app) that works with an attachment providing all 12-leads of a standard ECG system. The ST LEUIS study was designed to validate the smartphone ECG app and its ability to accurately assess the presence or absence of STEMI in patients presenting with chest pain compared with the gold standard 12-lead ECG...
March 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29143768/an-electronic-system-for-the-contactless-reading-of-ecg-signals
#15
Francesca Romana Parente, Marco Santonico, Alessandro Zompanti, Mario Benassai, Giuseppe Ferri, Arnaldo D'Amico, Giorgio Pennazza
The aim of this work is the development of a contactless capacitive sensory system for the detection of (Electrocardiographic) ECG-like signals. The acquisition approach is based on a capacitive coupling with the patient body performed by electrodes integrated in a front-end circuit. The proposed system is able to detect changes in the electric charge related to the heart activity. Due to the target signal weakness and to the presence of other undesired signals, suitable amplification stages and analogue filters are required...
October 28, 2017: Sensors
https://www.readbyqxmd.com/read/29134982/electrocardiographic-and-blood-pressure-measurements-in-captive-african-lions-panthera-leo-immobilized-with-xylazine-ketamine-combination
#16
T O Omóbòwálé, P I Otuh, O A Adejumobi, J O Abiola, T Adebiyi, B N Ogunro, A O Adeogun
Electrocardiographic and blood pressure measurements are extremely valuable diagnostic tools in the evaluationof the cardiovascular system of living animals. In this study, 6-lead electrocardiograms were recorded from five male captiveAfrican lions (Panthera leo). Also, blood pressure measurements were recorded and compared from three different sites;fore limb, hind limb and the tail, were recorded. Immobilization was done with a combination of Ketamine Hydrochloride(10mg/kg) and Xylazine (3mg/kg). Measurements were recorded as mean ± standard deviation...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29059302/office-and-home-blood-pressures-as-determinants-of-electrocardiographic-left-ventricular-hypertrophy-among-black-nigerians-compared-with-white-flemish
#17
Augustine N Odili, Lutgarde Thijs, Wen-Yi Yang, John O Ogedengbe, Maxwell M Nwegbu, Lotte Jacobs, Fang-Fei Wei, Ying-Mei Feng, Zhen-Yu Zhang, Tatiana Kuznetsova, Tim S Nawrot, Jan A Staessen
BACKGROUND: The association of electrocardiographic left ventricular hypertrophy (ECG-LVH) with blood pressure (BP) in Blacks living in sub-Saharan Africa remains poorly documented. METHODS: In 225 Black Nigerians and 729 White Flemish, we analyzed QRS voltages and voltage-duration products and 12 criteria diagnostic of ECG-LVH in relation to office BP (mean of 5 consecutive readings) and home BP (duplicate morning and evening readings averaged over 1 week). RESULTS: In multivariable analyses, QRS voltage and voltage-duration indexes were generally higher in Blacks than Whites...
November 1, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29026885/emergency-department-point-of-care-ultrasonography-improves-time-to-pericardiocentesis-for-clinically-significant-effusions
#18
Evan Avraham Alpert, Uri Amit, Larisa Guranda, Rafea Mahagna, Shamai A Grossman, Ariel Bentancur
OBJECTIVE: Our objective was to determine the utility of point-of-care ultrasound (POCUS) to identify and guide treatment of tamponade or clinically significant pericardial effusions in the emergency department (ED). METHODS: This was a retrospective cohort study of non-trauma patients who were diagnosed with large pericardial effusions or tamponade by the ED physician using POCUS. The control group was composed of those patients later diagnosed on the medical wards or incidentally in the ED by other means such as a computed tomography...
September 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/28965185/safety-pharmacokinetic-and-pharmacodynamics-of-erdafitinib-a-pan-fibroblast-growth-factor-receptor-fgfr-tyrosine-kinase-inhibitor-in-patients-with-advanced-or-refractory-solid-tumors
#19
Tomohiro Nishina, Shunji Takahashi, Ryota Iwasawa, Hidehisa Noguchi, Masayuki Aoki, Toshihiko Doi
Introduction This phase 1, open-label, multicenter, single-arm, dose-escalation study aimed to evaluate safety, pharmacokinetics (PK), and pharmacodynamics of erdafitinib (JNJ-42756493), an oral selective pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor, and to determine the recommended phase 2 dose in Japanese patients with advanced or refractory solid tumors. Methods Three to 6 patients were enrolled into sequentially escalating dose cohorts (erdafitinib 2, 4, or 6 mg) with a daily dosing schedule of 21-day cycles or a 7 days-on/7 days-off intermittent schedule (erdafitinib 10 mg or 12 mg) of 28-day cycles...
June 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/28928069/comments-on-the-new-international-criteria-for-electrocardiographic-interpretation-in-athletes
#20
Luis Serratosa-Fernández, Domingo Pascual-Figal, María Dolores Masiá-Mondéjar, María Sanz-de la Garza, Zigor Madaria-Marijuan, Juan Ramón Gimeno-Blanes, Carmen Adamuz
Sudden cardiac death is the most common medical cause of death during the practice of sports. Several structural and electrical cardiac conditions are associated with sudden cardiac death in athletes, most of them showing abnormal findings on resting electrocardiogram (ECG). However, because of the similarity between some ECG findings associated with physiological adaptations to exercise training and those of certain cardiac conditions, ECG interpretation in athletes is often challenging. Other factors related to ECG findings are race, age, sex, sports discipline, training intensity, and athletic background...
November 2017: Revista Española de Cardiología
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