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https://www.readbyqxmd.com/read/28484595/fetal-and-neonatal-programming-of-postnatal-growth-and-feed-efficiency-in-swine
#1
REVIEW
Yun Ji, Zhenlong Wu, Zhaolai Dai, Xiaolong Wang, Ju Li, Binggen Wang, Guoyao Wu
Maternal undernutrition or overnutrition during pregnancy alters organ structure, impairs prenatal and neonatal growth and development, and reduces feed efficiency for lean tissue gains in pigs. These adverse effects may be carried over to the next generation or beyond. This phenomenon of the transgenerational impacts is known as fetal programming, which is mediated by stable and heritable alterations of gene expression through covalent modifications of DNA and histones without changes in DNA sequences (namely, epigenetics)...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28429991/effects-of-medium-chain-triglycerides-on-intestinal-morphology-and-energy-metabolism-of-intrauterine-growth-retarded-weanling-piglets
#2
Li-Li Zhang, Hao Zhang, Yue Li, Tian Wang
It has been shown that there is a relationship between intrauterine growth retardation (IUGR) and postnatal intestinal damage involved in energy deficits. Therefore, the present study was conducted to investigate the effect of medium-chain triglycerides (MCT) on the intestinal morphology, intestinal function and energy metabolism of piglets with IUGR. At weaning (21 ± 1.1 d of age), 24 IUGR piglets and 24 normal birth weight (NBW) piglets were selected according to their birth weights (BW) (IUGR: 0.95 ± 0...
June 2017: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/28369652/early-versus-late-enteral-feeding-in-preterm-intrauterine-growth-restricted-neonates-with-antenatal-doppler-abnormalities-an-open-label-randomized-trial
#3
Vishal Vishnu Tewari, Sachin Kumar Dubey, Reema Kumar, Shakti Vardhan, C M Sreedhar, Girish Gupta
Background of the study: Enteral feeding in preterm neonates with intrauterine growth restriction (IUGR) and absent or reversed end diastolic flow (AREDF) on umbilical artery (UA) Doppler is delayed owing to an increased risk of necrotizing enterocolitis (NEC). Delaying enteral feeding with longer duration of parenteral nutrition (PN) carries an increased risk of sepsis. Objectives: To study early versus late feeding in preterm IUGR neonates for time required to attain sufficient feed volume to discontinue PN and increased risk of NEC or feed intolerance (FI)...
March 24, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28367192/correlation-between-maternal-and-childhood-vitb12-folic-acid-and-ferritin-levels
#4
Fatima Zeeshan, Attia Bari, Saima Farhan, Uzma Jabeen, Ahsan Waheed Rathore
OBJECTIVE: To determine the correlation between serum folic acid, vitamin B12 and ferritin of mother and child and to study various neonatal risk factors as a cause of anemia in children. METHODS: One hundred eighty children two months to two years of age admitted in the department of Pediatric Medicine of The Children's Hospital and The Institute of Child Health Lahore from January 2013 to January 2015 with common medical conditions having anemia were included...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28334746/a-newborn-with-transient-diabetes-mellitus-accompanied-by-ketoacidosis-attributable-to-a-zfp57-mutation
#5
Fatma Iyigun, Beyza Ozcan, Ferit Kulali, Istemi Han Celik, Semra Cetinkaya, Ahmet Yagmur Bas, Nihal Demirel
Hyperglycemia commencing within the first 6 months of life requires exogenous insulin therapy and, if the condition persists for >2 weeks, is termed neonatal diabetes mellitus (NDM). This rare illness is of two types: transient and permanent NDM. Most cases come to medical attention because of nonspecific symptoms, including intrauterine growth retardation, dehydration, difficulties in feeding and inadequate weight gain. In the present article, we describe an infant who smelt of ketones during examination and who was diagnosed with transient NDM caused by a ZFP57 mutation, accompanied by ketoacidosis...
February 18, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28143994/intra-uterine-growth-retardation-and-development-of-hypertension
#6
REVIEW
Haerani Rasyid, Syakib Bakri
Low birth weight (LBW) is defined as a birth weight of a liveborn infant of <2,500 gram. In developed countries, LBW is commonly caused by preterm birth; while in developing countries, it is mostly due to intrauterine growth retardation. The concept of developmental origins of adult diseases, particularly on late-onset diseases such as hypertension and kidney disease, implies that there is a correlation between intrauterine milieu, intrauterine growth retardation, premature birth and infant feeding. The 'fetal origin hypothesis' suggests that metabolic diseases are directly related to poor nutritional status in early life...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28046002/competition-for-materno-fetal-resource-partitioning-in-a-rabbit-model-of-undernourished-pregnancy
#7
Jorge Lopez-Tello, Maria Arias-Alvarez, Maria Angeles Jimenez-Martinez, Rosa Maria Garcia-Garcia, Maria Rodriguez, Pedro Luis Lorenzo Gonzalez, Ruben Bermejo-Poza, Antonio Gonzalez-Bulnes, Pilar Garcia Rebollar
The major goal of animal production is to obtain abundant and healthy meat for consumers. Maternal food restriction (MFR) is often applied in farms to reduce production costs. However, the suitability of MFR in livestock animals is questionable, as this management may compromise maternal fitness due to a severe negative energetic balance and can induce Intrauterine Growth Restriction (IUGR) and prenatal programming in the offspring. Here, we sought to determine, using pregnant rabbits, the consequences of MFR on maternal endocrine and metabolic status and conceptus development...
2017: PloS One
https://www.readbyqxmd.com/read/27901041/bainbridge-ropers-syndrome-caused-by-loss-of-function-variants-in-asxl3-a-recognizable-condition
#8
Alma Kuechler, Johanna Christina Czeschik, Elisabeth Graf, Ute Grasshoff, Ulrike Hüffmeier, Tiffany Busa, Stefanie Beck-Woedl, Laurence Faivre, Jean-Baptiste Rivière, Ingrid Bader, Johannes Koch, André Reis, Ute Hehr, Olaf Rittinger, Wolfgang Sperl, Tobias B Haack, Thomas Wieland, Hartmut Engels, Holger Prokisch, Tim M Strom, Hermann-Josef Lüdecke, Dagmar Wieczorek
Truncating ASXL3 mutations were first identified in 2013 by Bainbridge et al. as a cause of syndromic intellectual disability in four children with similar phenotypes using whole-exome sequencing. The clinical features - postulated by Bainbridge et al. to be overlapping with Bohring-Opitz syndrome - were developmental delay, severe feeding difficulties, failure to thrive and neurological abnormalities. This condition was included in OMIM as 'Bainbridge-Ropers syndrome' (BRPS, #615485). To date, a total of nine individuals with BRPS have been published in the literature in four reports (Bainbridge et al...
February 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27898951/intrauterine-growth-restricted-piglets-have-similar-gastric-emptying-rates-but-lower-rectal-temperatures-and-altered-blood-values-when-compared-with-normal-weight-piglets-at-birth
#9
C Amdi, M V Klarlund, J Hales, T Thymann, C F Hansen
Intrauterine growth-restricted (IUGR) piglets have lower survival rates and are more likely to have empty stomachs 24 h after birth than normal piglets. Although hypoglycemia may result from low colostrum intake per se, it is not known if slow gastric emptying may be an additional risk factor for poor immunization and glucose absorption in IUGR piglets. It is estimated that IUGR piglets consume less colostrum per kilogram BW than normal-weight piglets within the first 24 h, which could be due to a slower gastric emptying rate and a compromised energy metabolism...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27852422/differential-effects-of-young-maternal-age-on-child-growth
#10
Soo Hyun Yu, John Mason, Jennifer Crum, Claudia Cappa, David R Hotchkiss
BACKGROUND: The association of early maternal birthing age with smaller children has been widely observed. However, it is unclear if this is due to confounding by factors such as socioeconomic status, or the age at which child growth restriction first occurs. OBJECTIVE: To examine the effect of early maternal birthing age on the first-born child's height-for-age in a sample of developing countries in Africa, Asia, and Latin America. DESIGN: Cross-sectional data from Demographic Health Surveys from 18 countries were used, to select the first-born child of mothers aged 15-24 years and a range of potential confounding factors, including maternal height...
2016: Global Health Action
https://www.readbyqxmd.com/read/27525095/an-8-4-mb-3q26-33-3q28-microdeletion-in-a-patient-with-blepharophimosis-intellectual-disability-syndrome-and-a-review-of-the-literature
#11
Katrin Õunap, Sander Pajusalu, Olga Zilina, Tiia Reimand, Riina Žordania
3q26.33-3q27.2 microdeletion can be classified as a clinical entity characterized by intrauterine growth retardation, feeding problems in infancy, short stature, intellectual disability, hypotonia, dysmorphic facial features (medially sparse eyebrows, narrow horizontal palpebral fissures, epicanthal folds, flat nasal bridge and tip, short philtrum, and downturned corners of mouth), and teeth and feet abnormalities.
August 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27432287/clinical-significance-of-slightly-lateral-ventricular-enlargement-in-healthy-infants
#12
Hideki Minowa, Kouichiro Hirayama, Ikuyo Arai, Hajime Yasuhara, Reiko Ebisu, Ayako Ohgitani
OBJECTIVE: The aim of this study was to determine the clinical significance of slightly lateral ventricular enlargement. METHODS: We examined 1151 infants with a gestational age of 36 weeks or greater. We assessed for the presence of ventricular enlargement when apparent space was observed in the frontal horn or body of lateral ventricle by a transfontanel ultrasound scan. RESULTS: Two hundred and forty-eight infants had ventricular enlargement...
June 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27339251/impact-of-continuous-vs-bolus-feeding-on-splanchnic-perfusion-in-very-low-birth-weight-infants-a-randomized-trial
#13
Valentina Bozzetti, Giuseppe Paterlini, Paola De Lorenzo, Diego Gazzolo, Maria Grazia Valsecchi, Paolo E Tagliabue
OBJECTIVE: To detect changes in splanchnic perfusion and oxygenation induced by 2 different feeding regimens in infants with intrauterine growth restriction (IUGR) and those without IUGR. STUDY DESIGN: This was a randomized trial in 40 very low birth weight infants. When an enteral intake of 100 mL/kg/day was achieved, patients with IUGR and those without IUGR were randomized into 2 groups. Group A (n = 20) received a feed by bolus (in 10 minutes), then, after at least 3 hours, received the same amount of formula by continuous nutrition over 3 hours...
September 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27335275/spontaneous-intrauterine-growth-restriction-due-to-increased-litter-size-in-the-guinea-pig-programmes-postnatal-growth-appetite-and-adult-body-composition
#14
D M Horton, D A Saint, J A Owens, K L Kind, K L Gatford
Intrauterine growth restriction (IUGR) and subsequent neonatal catch-up growth are implicated in the programming of increased appetite, adiposity and cardiometabolic diseases. Guinea pigs provide an alternate small animal model to rodents to investigate mechanisms underlying prenatal programming, being relatively precocial at birth, with smaller litter sizes and undergoing neonatal catch-up growth after IUGR. The current study, therefore, investigated postnatal consequences of spontaneous IUGR due to varying litter size in this species...
June 23, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27304828/dietary-nucleotides-supplementation-improves-the-intestinal-development-and-immune-function-of-neonates-with-intra-uterine-growth-restriction-in-a-pig-model
#15
Lianqiang Che, Liang Hu, Yan Liu, Chuan Yan, Xie Peng, Qin Xu, Ru Wang, Yuanfang Cheng, Hong Chen, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Daiwen Chen, De Wu
The current study aimed to determine whether dietary nucleotides supplementation could improve growth performance, intestinal development and immune function of intra-uterine growth restricted (IUGR) neonate using pig as animal model. A total of 14 pairs of normal birth weight (NBW) and IUGR piglets (7 days old) were randomly assigned to receive a milk-based control diet (CON diet) or diet supplemented with nucleotides (NT diet) for a period of 21 days. Blood samples, intestinal tissues and digesta were collected at necropsy and analyzed for morphology, digestive enzyme activities, microbial populations, peripheral immune cells, expression of intestinal innate immunity and barrier-related genes and proteins...
2016: PloS One
https://www.readbyqxmd.com/read/27190278/detection-of-expressional-changes-induced-by-intrauterine-growth-restriction-in-the-developing-rat-pancreas
#16
Lin Zhang, Wei Chen, Yuee Dai, Ziyang Zhu, Qianqi Liu
Intrauterine growth retardation (IUGR) is a disorder that can result in permanent changes in the physiology and metabolism of the newborn, which increased the risk of disease in adulthood. Evidence supports IUGR as a risk factor for the development of diabetes mellitus, which could reflect changes in pancreas developmental pathways. We sought to characterize the IUGR-induced alterations of the complex pathways of pancreas development in a rat model of IUGR. We analyzed the pancreases of Sprague Dawley rats after inducing IUGR by feeding a maternal low calorie diet from gestational day 1 until term...
July 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27188336/effects-of-intrauterine-growth-retardation-and-bacillus-subtilis-pb6-supplementation-on-growth-performance-intestinal-development-and-immune-function-of-piglets-during-the-suckling-period
#17
Liang Hu, Xie Peng, Hong Chen, Chuan Yan, Yan Liu, Qin Xu, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Jian Li, De Wu, Lianqiang Che
OBJECTIVES: The aim of this study was to investigate the effects of intrauterine growth retardation (IUGR) and Bacillus subtilis PB6 supplementation in formula milk (FORM) on growth performance, intestinal development and immune function of neonates using a porcine model. METHODS: Fourteen pairs of normal birth weight and IUGR piglets (7 days old) were randomly assigned to receive FORM or FORM supplemented with B. subtilis PB6 (FORM-BsPB6) for a period of 21 days...
May 17, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27050741/application-of-spectroscopy-1-hmrs-to-assess-liver-metabolite-concentrations-in-rats-with-intrauterine-growth-restriction
#18
Tao Wang, Pingyang Chen, Dujun Bian, Juncao Chen
OBJECTIVE: Proton magnetic resonance spectroscopy ((1)H-MRS) measurement of liver metabolism in intrauterine growth restriction rats has seldom been reported. This study investigated the application of (1)H-MRS in assessing liver metabolism in newborn pups that experienced intrauterine growth restriction. METHODS: Intra-uterine growth restriction was established by feeding rats low-protein diets during pregnancy. Newborn pups received conventional magnetic resonance imaging and (1)H-MRS using a 3...
September 27, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26907266/exploring-the-role-of-different-neonatal-nutrition-regimens-during-the-first-week-of-life-by-urinary-gc-ms-metabolomics
#19
Angelica Dessì, Antonio Murgia, Rocco Agostino, Maria Grazia Pattumelli, Andrea Schirru, Paola Scano, Vassilios Fanos, Pierluigi Caboni
In this study, a gas-chromatography mass spectrometry (GC-MS) metabolomics study was applied to examine urine metabolite profiles of different classes of neonates under different nutrition regimens. The study population included 35 neonates, exclusively either breastfed or formula milk fed, in a seven-day timeframe. Urine samples were collected from intrauterine growth restriction (IUGR), large for gestational age (LGA), and appropriate gestational age (AGA) neonates. At birth, IUGR and LGA neonates showed similarities in their urine metabolite profiles that differed from AGA...
February 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26895664/early-postnatal-feed-restriction-reduces-liver-connective-tissue-levels-and-affects-h3k9-acetylation-state-of-regulated-genes-associated-with-protein-metabolism-in-low-birth-weight-pigs
#20
Constance Nebendahl, Solvig Görs, Elke Albrecht, Ricarda Krüger, Karen Martens, Katrin Giller, Harald M Hammon, Gerald Rimbach, Cornelia C Metges
Intrauterine growth retardation is associated with metabolic consequences in adulthood. Since our previous data indicate birth weight-dependent effects of feed restriction (R) on protein degradation processes in the liver, it should be investigated whether effects on connective tissue turnover are obvious and could be explained by global changes of histone H3K9me3 and H3K9ac states in regulated genes. For this purpose, female littermate pigs with low (U) or normal (N) birth weight were subjected to 3-week R (60% of ad libitum fed controls) with subsequent refeeding (REF) for further 5 weeks...
March 2016: Journal of Nutritional Biochemistry
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