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https://www.readbyqxmd.com/read/29144024/epidemiology-of-type-1-diabetes-in-polish-children-a-multicentre-cohort-study
#1
Mieczysław Szalecki, Marta Wysocka-Mincewicz, Anna Ramotowska, Artur Mazur, Lucyna Lisowicz, Iwona Ben-Skowronek, Joanna Sieniawska, Bożena Klonowska, Dorota Charemska, Jolanta Nawrotek, Irena Jałowiec, Artur Bossowski, Milena Jamiołkowska, Beata Pyrżak, Grażyna Miszkurka, Agnieszka Szypowska
BACKGROUND: The incidence of childhood Type-1 diabetes (T1D) varies greatly between populations and the estimates and/or predictions of the rates would aid in adequate planning of health care resources. The study's aim was to assess the incidence of T1D in the paediatric population of eastern and central Poland. METHODS: In this cohort study covering the period from January 2010 to December 2014 data were collected for children and adolescents below 18 years of age with newly diagnosed T1D, living in eastern and central Poland...
November 16, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29141958/dna-methylation-defines-regional-identity-of-human-intestinal-epithelial-organoids-and-undergoes-dynamic-changes-during-development
#2
Judith Kraiczy, Komal M Nayak, Kate J Howell, Alexander Ross, Jessica Forbester, Camilla Salvestrini, Roxana Mustata, Sally Perkins, Amanda Andersson-Rolf, Esther Leenen, Anke Liebert, Ludovic Vallier, Philip C Rosenstiel, Oliver Stegle, Gordon Dougan, Robert Heuschkel, Bon-Kyoung Koo, Matthias Zilbauer
OBJECTIVE: Human intestinal epithelial organoids (IEOs) are increasingly being recognised as a highly promising translational research tool. However, our understanding of their epigenetic molecular characteristics and behaviour in culture remains limited. DESIGN: We performed genome-wide DNA methylation and transcriptomic profiling of human IEOs derived from paediatric/adult and fetal small and large bowel as well as matching purified human gut epithelium. Furthermore, organoids were subjected to in vitro differentiation and genome editing using CRISPR/Cas9 technology...
November 15, 2017: Gut
https://www.readbyqxmd.com/read/29133169/ureteroscopy-for-paediatric-calculi-the-twin-surgeon-model
#3
Bhaskar K Somani, Stephen Griffin
We describe our 'Tips and tricks' of ureteroscopy and lasertripsy (URSL) for paediatric ureteric calculi. All regional referrals directed to the paediatric urologist are discussed in a formal stone multidisciplinary team (MDT) meeting with urologists, radiologists, and biochemical pathologist. A paediatric urologist (SG) and an experienced adult endourologist (BS) do these stone procedures jointly as a twin-surgeon team approach for each patient.
November 10, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29125228/routine-follow-up-of-preterm-infants-in-new-zealand
#4
Nicole Gledhill, Gabrielle Scott, Nathalie Ks de Vries
AIM: To describe the routine follow-up of preterm infants by different District Health Boards (DHBs) in New Zealand (NZ), and to compare current practice with international guidelines. METHODS: A descriptive survey of the existing routine follow-up management of preterm infants in NZ. From November 2015 until January 2016, a questionnaire was sent out across NZ to one paediatrician (n = 24) and one Child Development Service (CDS) (n = 20) from each DHB. All paediatricians responded and 85% of the CDSs responded...
November 10, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29113732/oxidative-stress-in-ageing-and-disease-development-studied-by-ft-ir-spectroscopy
#5
Jane Anastassopoulou, Maria Kyriakidou, Stylianos Kyriazis, Andreas F Mavrogenis, Vasiliki Mamareli, Ioannis Mamarelis, Marianna Petra, Efthymia Malesiou, Christoforos Kotoulas, Panagiota Kolovou, Emmanouil Koutoulakis, Athina Markouizou, Theophile Theophanides
FT-IR spectroscopy was used to investigate the effect of oxidative stress and to approach the mechanism on cancer bone demineralization, aortic valve mineralization and heterotopic ossification on disease development. The FT-IR spectra obtained from paediatric, adult bone and ex vivo irradiated adult healthy bone with a dose of 20Gy were compared with those of healthy bone. The increase of band intensity changes of vasCH2,vsCH2 in the region 3000-2850cm(-1) depended on aging, the disease progression and the dose of irradiation...
November 4, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29081857/analysis-of-a-paediatric-orthopaedic-network-a-six-year-experience-in-the-south-west-of-the-united-kingdom
#6
D Bruce, C Kocialkowski, F Bintcliffe, F Monsell, J Barnes, R Brown
PURPOSE: We report our experience of a paediatric orthopaedic network, based on a 'hub and spoke' model, covering the South West of the United Kingdom. We identify the areas of most clinical concern, the effect of the network on stream-lining patient management and the benefits of the network to the clinician. METHODS: Prospective data were collected from the minutes of the bi-annual meetings of the South West Paediatric Network (UK) between November 2006 and May 2012...
October 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29079584/smoke-free-legislation-and-paediatric-hospitalisations-for-acute-respiratory-tract-infections-national-quasi-experimental-study-with-unexpected-findings-and-important-methodological-implications
#7
Jasper V Been, Daniel F Mackay, Christopher Millett, Ireneous Soyiri, Constant P van Schayck, Jill P Pell, Aziz Sheikh
OBJECTIVES: We investigated whether Scottish implementation of smoke-free legislation was associated with a reduction in unplanned hospitalisations or deaths ('events') due to respiratory tract infections (RTIs) among children. DESIGN: Interrupted time series (ITS). SETTING/PARTICIPANTS: Children aged 0-12 years living in Scotland during 1996-2012. INTERVENTION: National comprehensive smoke-free legislation (March 2006)...
October 27, 2017: Tobacco Control
https://www.readbyqxmd.com/read/29069378/the-effect-of-a-performance-based-financing-program-on-hiv-and-maternal-child-health-services-in-mozambique-an-impact-evaluation
#8
Yogesh Rajkotia, Omer Zang, Pierre Nguimkeu, Jessica Gergen, Iva Djurovic, Paula Vaz, Franscisco Mbofana, Kebba Jobarteh
Performance-based financing (PBF) is a mechanism by which health providers are paid on the basis of outputs or results delivered. A PBF program was implemented on the provision of HIV, prevention of mother-to child HIV transmission (PMTCT), and maternal/child health (MCH) services in two provinces of Mozambique. A retrospective case-control study design was used in which PBF provinces were matched with control provinces to evaluate the impact of PBF on 18 indicators. Due to regional heterogeneity, we evaluated the intervention sites (North and South) separately...
December 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29065344/quantitative-analysis-of-the-amygdala-thalamus-and-hippocampus-on-magnetic-resonance-images-in-paediatric-bipolar-disorders-and-compared-with-the-children-of-bipolar-parents-and-healthy-control
#9
Seher Akbaş, Mert Nahir, Mennan Ece Pirzirenli, Cihat Dündar, Meltem Ceyhan, Gökhan Sarısoy, Bünyamin Şahin
MR imaging studies in paediatric bipolar disorder have particularly focused on the amygdala and hippocampus, subcortical structures, and to a lesser extent on the thalamus. The purpose of this study was to perform structural analysis of the regions of interest (ROI) associated with mood regulation. In this study 18 children (between the ages of 12-18) were matched according to their age and sex and were divided into three groups. These were: a paediatric bipolar disorder group, risk group and a healthy control group...
December 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29062344/assessment-of-hospital-based-adult-triage-at-emergency-receiving-areas-in-hospitals-in-northern-uganda
#10
Keneth Opiro, Lee Wallis, Martin Ogwang
BACKGROUND: Limited health service resources must be used in a manner which does "the most for the most". This is partly achieved through the use of a triage system. Whereas efforts have been made to introduce paediatric triage in Uganda such as Emergency Triage Assessment and Treatment Plus (ETAT+), it is not clear if hospitals have local protocols for adult triage being used in each setting. OBJECTIVES: To determine the presence of existing hospital triage systems, the cadre of staff undertaking triage and barriers to development/improvement of formal triage systems...
June 2017: African Health Sciences
https://www.readbyqxmd.com/read/29058568/retention-and-use-of-newborn-resuscitation-skills-following-a-series-of-helping-babies-breathe-trainings-for-midwives-in-rural-ghana
#11
Darren Eblovi, Patricia Kelly, Georgina Afua, Sarah Agyapong, Siddhartha Dante, Matthew Pellerite
BACKGROUND: The Helping Babies Breathe (HBB) program teaches basic newborn resuscitation techniques to birth attendants in low-resource settings. Previous studies have demonstrated a decrease in mortality following training, mostly in large hospitals. However, low-volume clinics in rural regions with no physician immediately available likely experience a greater relative burden of newborn mortality. This study aimed to determine the impact of HBB trainings provided to rural Ghanaian midwives on their skills retention and on first 24 hour mortality of the newborns they serve...
2017: Global Health Action
https://www.readbyqxmd.com/read/29056227/intravenous-regional-anaesthesia-bier-s-block-for-pediatric-forearm-fractures-in-a-pediatric-emergency-department-experience-from-2003-to-2014
#12
Ivan S Y Chua, S L Chong, Gene Y K Ong
STUDY OBJECTIVES: To evaluate the efficacy (length of stay in the emergency department and failure rate of Bier's block) and safety profile (death and major complications) of Bier's block in its use for manipulation and reduction of paediatric forearm fractures. METHODS: This is a retrospective cohort study of pediatric patients in KKWomen's and Children's Hospital Children's Emergency Department with forearm fractures between Jan 2003 and Dec 2014 who underwent manipulation and reduction using Bier's block...
October 16, 2017: Injury
https://www.readbyqxmd.com/read/29055895/the-pattern-of-paediatric-blast-injury-in-afghanistan
#13
Daniel C Thompson, R J Crooks, J C Clasper, A Lupu, S A Stapley, D J Cloke
INTRODUCTION: Between 2009 and 2015, 3746 children died, and 7904 were injured as a result of armed conflict within Afghanistan. Improvised explosive devices (IEDs) and explosive remnants of war accounted for 29% of child casualties in 2015. The aim of this study was to review the burden of paediatric blast injuries admitted to Camp Bastion, Afghanistan, and to investigate the hypothesis that children suffer proportionally more head injuries than adults. METHOD: A retrospective analysis was undertaken of prospectively collected data derived from the UK Joint Theatre Trauma Registry of ambulant paediatric (aged 2-15 years) admissions with blast injuries at the Role 3 Field Hospital, Camp Bastion from June 2006 to March 2013...
October 21, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29052340/absence-of-neurocognitive-disadvantage-associated-with-paediatric-hiv-subtype-a-infection-in-children-on-antiretroviral-therapy
#14
Paul Bangirana, Theodore D Ruel, Michael J Boivin, Satish K Pillai, Leila B Giron, Alla Sikorskii, Asish Banik, Jane Achan
INTRODUCTION: Infection with HIV subtype A has been associated with poorer neurocognitive outcomes compared to HIV subtype D in Ugandan children not eligible for antiretroviral therapy (ART). In this study, we sought to determine whether subtype-specific differences are also observed among children receiving ART. MATERIALS AND METHODS: Children were recruited from a clinical trial in which they were randomized to receive either lopinavir (LPV)- or non-nucleoside reverse transcriptase inhibitor (NNRTI)- based ART (NCT00978068)...
October 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29029855/improving-mortality-outcomes-of-stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-regional-burns-centre-experience
#15
M Nizamoglu, J A Ward, Q Frew, H Gerrish, N Martin, A Shaw, D Barnes, O Shelly, B Philp, N El-Muttardi, P Dziewulski
INTRODUCTION: Stevens Johnson Syndrome/toxic epidermal necrolysis (SJS/TEN) are rare, potentially fatal desquamative disorders characterised by large areas of partial thickness skin and mucosal loss. The degree of epidermal detachment that occurs has led to SJS/TEN being described as a burn-like condition. These patients benefit from judicious critical care, early debridement and meticulous wound care. This is best undertaken within a multidisciplinary setting led by clinicians experienced in the management of massive skin loss and its sequelae...
October 10, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29021883/brodie-s-abscess-of-posterior-ilium-with-gluteal-syndrome-an-unusual-cause-of-paediatric-low-back-pain-a-case-report
#16
G Behera, M Poduval, D K Patro, S Sahoo
Brodie's abscess is a variety of subacute osteomyelitis with a long duration of presentation and intermittent pain. It usually involves the metaphyseal region of long bones of the lower limbs. Brodie's abscess of pelvic bone is very rare. Involvement of posterior ilium with gluteal syndrome is extremely unusual and can be easily missed or misdiagnosed. We present a 9-year old boy who reported to us with intermittent low back pain of three months duration without any other constitutional symptoms. Clinically, there was mild tenderness over the posterior ilium...
July 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29018578/the-care-of-adolescents-and-young-adults-with-cancer-results-of-the-esmo-siope-survey
#17
Emmanouil Saloustros, Daniel P Stark, Kyriaki Michailidou, Giannis Mountzios, Laurence Brugieres, Fedro Alessandro Peccatori, Svetlana Jezdic, Samira Essiaf, Jean-Yves Douillard, Stefan Bielack
INTRODUCTION: Adolescents and young adults (AYA) with cancer require dedicated clinical management and care. Little is known about the training and practice of European healthcare providers in regard to AYA and the availability of specialised services. METHODS: A link to an online survey was sent to members of the European Society for Medical Oncology (ESMO) and the European Society for Paediatric Oncology (SIOPE). The link was also sent to ESMO National Representatives and circulated to other European oncology groups...
2017: ESMO Open
https://www.readbyqxmd.com/read/28992986/pros-and-cons-of-vaccination-against-disease-caused-by-serogroup-b-meningococcal-disease
#18
REVIEW
Miguel Delgado Rodríguez, Ángela Domínguez García
A vaccine has recently been approved in the EU against meningococcal serogroup B, the main cause of meningococcal disease. There is a fierce debate about the decision regarding a universal vaccination in infants older than 2 months, as recommended by the majority of scientific societies. In western Europe the only country to have included the universal vaccination is the United Kingdom, with a lower incidence of the disease than Ireland. Other countries have also adopted it, such as the Czech Republic, Cuba and certain regions of Italy...
October 7, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28988149/neural-dysfunction-during-temporal-discounting-in-paediatric-attention-deficit-hyperactivity-disorder-and-obsessive-compulsive-disorder
#19
Luke J Norman, Christina O Carlisi, Anastasia Christakou, Kaylita Chantiluke, Clodagh Murphy, Andrew Simmons, Vincent Giampietro, Michael Brammer, David Mataix-Cols, Katya Rubia
Both Attention-Deficit/Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD) are associated with choice impulsivity, i.e. the tendency to prefer smaller immediate rewards over larger delayed rewards. However, the extent to which this impulsivity is mediated by shared or distinct underlying neural mechanisms is unclear. Twenty-six boys with ADHD, 20 boys with OCD and 20 matched controls (aged 12-18) completed an fMRI version of an individually adjusted temporal discounting (TD) task which requires choosing between a variable amount of money now or £100 in one week, one month or one year...
November 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28969936/the-dna-methylation-landscape-of-cd4-t-cells-in-oligoarticular-juvenile-idiopathic-arthritis
#20
Raul A Chavez-Valencia, Rachel C Chiaroni-Clarke, David J Martino, Jane E Munro, Roger C Allen, Jonathan D Akikusa, Anne-Louise Ponsonby, Jeffrey M Craig, Richard Saffery, Justine A Ellis
Juvenile idiopathic arthritis (JIA) is presumed to be driven by an adverse combination of genes and environment. Epigenetic processes, including DNA methylation, act as a conduit through which the environment can regulate gene activity. Altered DNA methylation has been associated with adult autoimmune rheumatic diseases such as rheumatoid arthritis, but studies are lacking for paediatric autoimmune rheumatic diseases including JIA. Here, we performed a genome-scale case-control analysis of CD4(+) T cell DNA methylation from 56 oligoarticular JIA (oJIA) cases and 57 age and sex matched controls using Illumina HumanMethylation450 arrays...
September 29, 2017: Journal of Autoimmunity
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