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conA liver and microbiota

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https://www.readbyqxmd.com/read/25435303/natural-killer-t-cells-play-a-necessary-role-in-modulating-of-immune-mediated-liver-injury-by-gut-microbiota
#1
Jianing Chen, Yingfeng Wei, Jianqin He, Guangying Cui, Yunan Zhu, Chong Lu, Yulong Ding, Rufeng Xue, Li Bai, Toshimitsu Uede, Lanjuan Li, Hongyan Diao
Gut microbiota are implicated in many liver diseases. Concanavalin A (ConA)-induced hepatitis is a well-characterized murine model of fulminant immunological hepatic injury. Oral administration of pathogenic bacteria or gentamycin to the mice before ConA injection, liver injury and lymphocyte distribution in liver and intestine were assessed. Our data show that administration of pathogenic bacteria exacerbated the liver damage. There was more downregulation of activation-induced natural killer T (NKT) cells in the liver of pathogenic bacteria-treated ConA groups...
2014: Scientific Reports
https://www.readbyqxmd.com/read/25068658/the-microbiota-regulates-susceptibility-to-fas-mediated-acute-hepatic-injury
#2
Stela Celaj, Michael W Gleeson, Jie Deng, George A O'Toole, Thomas H Hampton, Martin F Toft, Hilary G Morrison, Mitchell L Sogin, Juan Putra, Arief A Suriawinata, James D Gorham
Whereas a significant role for intestinal microbiota in affecting the pathogenesis and progression of chronic hepatic diseases is well documented, the contribution of the intestinal flora to acute liver injury has not been extensively addressed. Elucidating the influence of the intestinal microbiota on acute liver inflammation would be important for better understanding the transition from acute injury to chronic liver disease. Using the Concanavalin A (ConA)-induced liver injury model in laboratory mice, we show that the severity of acute hepatic damage varies greatly among genetically identical mice raised in different environments and harboring distinct microbiota...
September 2014: Laboratory Investigation; a Journal of Technical Methods and Pathology
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