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Structural competence

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https://www.readbyqxmd.com/read/29241259/-competence-based-catalogue-of-learning-objectives-for-rehabilitation-physical-medicine-naturopathic-treatment-revised-version-joint-recommendations-of-the-german-society-of-rehabilitation-science-and-the-german-society-of-physical-medicine-and-rehabilitation
#1
Wilfried Mau, Max Emanuel Liebl, Ruth Deck, Uwe Lange, Ulrich Christian Smolenski, Susanne Walter, Christoph Gutenbrunner
Since the first publication of learning objectives for the interdisciplinary subject "Rehabilitation, Physical Medicine, Naturopathic Treatment" in undergraduate medical education in 2004 a revision is reasonable due to heterogenous teaching programmes in the faculties and the introduction of the National Competence Based Catalogue of Learning Objectives in Medicine as well as the "Masterplan Medical Education 2020". Therefore the German Society of Rehabilitation Science and the German Society of Physical Medicine and Rehabilitation started a structured consensus process using the DELPHI-method to reduce the learning objectives and arrange them more clearly...
December 2017: Die Rehabilitation
https://www.readbyqxmd.com/read/29241118/plhint-a-knowledge-driven-computational-approach-based-on-the-intermolecular-h-bond-interactions-at-the-protein-ligand-interface-from-docking-solutions
#2
Sivakumar Prasanth Kumar
The tendency of docking scoring functions to generate crystal close conformations of ligands bound to protein structures face limitations in not reproducing the exact crystal intermolecular contacts in dock poses. Intermolecular H bond contacts enumerated at the protein-docked ligand interface can be used to train scoring models and improve virtual screening performance. There is a need to incorporate additional knowledge of protein-ligand H bond contacts in extension to crystal contacts from docking solutions within the reproducibility efficiency of the docking program...
December 6, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29240861/a-systematic-review-of-lower-lip-anatomy-mechanics-of-local-flaps-and-special-considerations-for-lower-lip-reconstruction
#3
Stefanos Boukovalas, Alexis L Boson, Joshua P Hays, C Helen Malone, Eric L Cole, Richard F Wagner
<p>Reconstruction of defects of the lower lip can be very challenging. The aim of this review is to analyze the unique characteristics of lower lip anatomy and provide a systematic approach for lower lip reconstruction. A review of current literature was performed using the PubMed database. Articles analyzing the anatomic and histologic characteristics of the lower lip, mechanics of local faps, and different lower lip recon-struction techniques were included. Articles focused on lower lip reconstruction with free faps were excluded...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29240396/casting-a-wider-net-rational-synthesis-design-of-low-dimensional-bulk-materials
#4
Katherine A Benavides, Iain W H Oswald, Julia Y Chan
The discovery of novel magnetic and electronic properties in low-dimensional materials has led to the pursuit of hierarchical materials with specific substructures. Low-dimensional solids are highly anisotropic by nature and show promise in new quantum materials leading to exotic physical properties not realized in three-dimensional materials. We have the opportunity to extend our synthetic strategy of the flux-growth method to designing single crystalline low-dimensional materials in bulk. The goal of this Account is to highlight the synthesis and physical properties of several low-dimensional intermetallic compounds containing specific structural motifs that are linked to desirable magnetic and electrical properties...
December 14, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29240291/novel-4-amino-1-2-3-triazole-inhibitors-of-indoleamine-2-3-dioxygenase-form-a-long-lived-complex-with-the-enzyme-and-display-exquisite-cellular-potency
#5
Julie Alexandre, Michael Swan, Mike Latchem, Dean Boyall, John Pollard, Stuart Hughes, James Westcott
Indoleamine-2,3 dioxygenase (IDO) has emerged as a central regulator of immune responses in both normal and disease biology. Due to its established role in promoting tumour immune escape, IDO has become an attractive target for cancer treatment. We have identified a novel series of highly cell potent IDO inhibitors based on a 4-amino-1,2,3-triazole core. Comprehensive kinetic, biochemical and structural studies demonstrate that compounds from this series have a non-competitive kinetic mechanism-of-action with respect to the tryptophan substrate...
December 14, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29238718/effects-of-structured-physical-activity-program-on-chinese-young-children-s-executive-functions-and-perceived-physical-competence-in-a-day-care-center
#6
Shanying Xiong, Xianxiong Li, Kun Tao
Purpose: To examine the effects of a structured physical activity program on executive functions and perceived physical competence as compared to a traditional recess among preschool children. Methods: Participants were 40 preschool children aged 4-5 from an urban child care center in a southern Chinese metropolitan area. Prior to the intervention, baseline assessments of children's executive functions and perceived physical competence were conducted. Children were then assigned to (1) intervention condition: a structured physical activity intervention group; (2) control condition: free-activity recess...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29237732/diverse-nadase-effector-families-mediate-interbacterial-antagonism-via-the-type-vi-secretion-system
#7
Jenny Y Tang, Nathan P Bullen, Shehryar Ahmad, John C Whitney
The bacterial type VI secretion system (T6SS) mediates antagonistic cell-cell interactions between competing Gram-negative bacteria. In plant-beneficial bacteria, this pathway has been shown to suppress the growth of bacterial pathogens; however, the identification and mode of action of T6SS effector proteins that mediate this protective effect remain poorly defined. Here, we identify two previously uncharacterized effectors required for interbacterial antagonism by the plant commensal bacterium Pseudomonas protegens...
December 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29235882/early-warning-systems-for-the-management-of-chronic-heart-failure-a-systematic-literature-review-of-cost-effectiveness-models
#8
Fernando Albuquerque de Almeida, Maiwenn Al, Ron Koymans, Kadir Caliskan, Ankie Kerstens, Johan L Severens
Introduction Describing the general and methodological characteristics of decision-analytical models used in the economic evaluation of early warning systems for the management of chronic heart failure patients and performing a quality assessment of their methodological characteristics is expected to provide concise and useful insight to inform the future development of decision-analytical models in the field of heart failure management. Areas covered The literature on decision-analytical models for the economic evaluation of early warning systems for the management of chronic heart failure patients was systematically reviewed...
December 13, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29234321/viral-impact-in-autoimmune-diseases-expanding-the-x-chromosome-nucleolus-nexus-hypothesis
#9
Wesley H Brooks
Viruses are suspected of significant roles in autoimmune diseases but the mechanisms are unclear. We get some insight by considering demands a virus places on host cells. Viruses not only require production of their own proteins, RNA and/or DNA, but also production of additional cellular machinery, such as ribosomes, to handle the increased demands. Since the nucleolus is a major site of RNA processing and ribonucleoprotein assembly, nucleoli are targeted by viruses, directly when viral RNA and proteins enter the nucleolus and indirectly when viruses induce increased expression of cellular polyamine genes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29233433/interprofessional-objective-structured-teaching-exercise-ioste-to-train-preceptors
#10
Livia R M McCutcheon, Kathryn Whitcomb, Craig D Cox, Mary S Klein, Hansel Burley, Terrance Youngblood, Cynthia Raehl
BACKGROUND AND PURPOSE: Interprofessional education (IPE) is important in the education of all health care students, yet limited IPE training has been provided to preceptors who train these students in the clinical setting. Simulation using the standardized student model has been used to train health care preceptors in medicine. To our knowledge, there are no reports utilizing interprofessional objective structured teaching exercises (iOSTE) to train pharmacy preceptors. The primary objectives of this pilot study were to evaluate the effects of iOSTE on the pharmacy preceptors' perceived importance of the Interprofessional Education Collaborative (IPEC) core competencies and confidence in precepting interprofessional students...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233415/development-and-evaluation-of-an-intermediate-level-elective-course-on-medical-spanish-for-pharmacy-students
#11
Robert Mueller
BACKGROUND AND PURPOSE: The Spanish-speaking population in the United States is increasing rapidly, and there is a need for additional educational efforts, beyond teaching basic medical Spanish terminology, to increase the number of Spanish-speaking pharmacists able to provide culturally appropriate care to this patient population. This article describes the development and evaluation of an intermediate-level elective course where students integrated pharmacy practice skills with Spanish-language skills and cultural competency...
March 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233149/advances-in-clinical-pharmacy-education-in-germany-a-quasi-experimental-single-blinded-study-to-evaluate-a-patient-centred-clinical-pharmacy-course-in-psychiatry
#12
Monika Dircks, Andreas Mayr, Annette Freidank, Johannes Kornhuber, Frank Dörje, Kristina Friedland
BACKGROUND: The pharmacy profession has shifted towards patient-centred care. To meet the new challenges it is necessary to provide students with clinical competencies. A quasi-experimental single-blinded teaching and learning study was carried out using a parallel-group design to evaluate systematically the benefits of clinical teaching in pharmacy education in Germany. METHODS: A clinical pharmacy course on a psychiatric ward was developed and implemented for small student groups...
December 12, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29232621/timing-of-poverty-in-childhood-and-adolescent-health-evidence-from-the-us-and-uk
#13
Michael J Green, Haley Stritzel, Chelsea Smith, Frank Popham, Robert Crosnoe
Childhood poverty is associated with poorer adolescent health and health behaviours, but the importance of the timing of poverty remains unclear. There may be critical or sensitive periods in early life or early adolescence, or poverty may have cumulative effects throughout childhood. Understanding when poverty is most important can support efficient timing of interventions to raise family income or buffer against the effects of low income, but answers may vary across social contexts. The US and the UK are a useful comparison with similar liberal approaches to cash transfers, but very different approaches to healthcare provision...
December 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29232209/recent-progress-in-understanding-hiv-reservoirs
#14
Hsiao-Hsuan Kuo, Mathias Lichterfeld
PURPOSE OF REVIEW: Reservoirs of HIV-1-infected cells persist long-term despite highly effective antiretroviral suppression therapy and represent the main barrier against a cure for HIV-1. This review summarizes recent advances in understanding the complexity and diversity of viral reservoir cells. RECENT FINDINGS: Latently infected memory CD4 T cells are the predominant cell compartment responsible for viral persistence, but some studies suggest that myeloid cells, and possibly hematopoietic progenitors, can also serve as long-term viral reservoirs...
December 11, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29232126/alkali-and-alkaline-earth-metal-derivatives-of-disila-bridged-podands-coordination-chemistry-and-structural-diversity
#15
Fabian Dankert, Carsten Donsbach, Christopher-Nils Mais, Kirsten Reuter, Carsten von Hänisch
Within this study, the synthesis and coordination chemistry of open-chain ligands bearing disila-units is presented. Instead of basic 1:1 complexes, structural diversity was discovered in the variety of ligand and salt. Stable complexes of alkali and alkaline earth metal complexes were obtained by equimolar reactions of different salts with the disila-bridged podands 8,9-disila-EO5 (1) and 11,12-disila-EO7 (2) (EO5 = pentaethylene glycol; EO7 = heptaethylene glycol). The respective alkaline earth metal complexes of the type [Ca(8,9-disila-EO5)(OTf)2] (3), [Sr(8,9-disila-EO5)I2] (5), [Sr(11,12-disila-EO7)I]I (6), and [Ba(11,12-disila-EO7)OTf2] (7) (OTf = CF3SO3-) were characterized via single-crystal X-ray diffraction analyses...
December 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29230711/hospital-wide-education-committees-and-high-quality-residency-training-a%C3%A2-qualitative-study
#16
Milou E W M Silkens, Irene A Slootweg, Albert J J A Scherpbier, Maas Jan Heineman, Kiki M J M H Lombarts
INTRODUCTION: High-quality residency training is of utmost importance for residents to become competent medical specialists. Hospital-wide education committees have been adopted by several healthcare systems to govern postgraduate medical education and to support continuous quality improvement of residency training. To understand the functioning and potential of such committees, this study examined the mechanisms through which hospital-wide education committees strive to enable continuous quality improvement in residency training...
December 11, 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/29230513/-interprofessional-approaches-in-undergraduate-medical-education
#17
REVIEW
Irina Cichon, Bernadette Klapper
Social change and the subsequent increase in the complexity of patient care create new challenges for all health care professionals that can only be met by close collaboration. Good cooperation between professionals from all healthcare backgrounds has proven to be essential and should therefore play a larger role in educational and study contexts.It is for this reason that over the past few years more and more countries are requiring cooperative skills and competencies in formal medical training and consequently implementing this training in their healthcare systems...
December 11, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29230320/factors-promoting-and-inhibiting-sustained-impact-of-a-mental-health-task-shifting-program-for-hiv-providers-in-ethiopia
#18
D Jerene, M Biru, A Teklu, T Rehman, A Ruff, L Wissow
Background: Task-shifting mental health into general medical care requires more than brief provider training. Generalists need long-term support to master new skills and changes to work context are required to sustain change in the face of competing priorities. We examined program and context factors promoting sustainability of a mental health task-shifting training for hospital-based HIV providers in Ethiopia. Methods: Convergent mixed-methods quasi-experimental study...
2017: Global Mental Health
https://www.readbyqxmd.com/read/29229337/receptor-protein-of-lysinibacillus-sphaericus-mosquito-larvicidal-toxin-displays-amylomaltase-activity
#19
Mahima Sharma, Gagan D Gupta, Vinay Kumar
The activated binary toxin (BinAB) from Lysinibacillus sphaericus binds to surface receptor protein (Cqm1) on the midgut cell membrane and kills Culex quinquefasciatus larvae on internalization. Cqm1 is attached to cells via a glycosyl-phosphatidylinositol (GPI) anchor. It has been classified as a member of glycoside hydrolase family 13 of the CAZy database. Here, we report characterization of the ordered domain (residues 23-560) of Cqm1. Gene expressing Cqm1 of BinAB susceptible mosquito was chemically synthesized and the protein was purified using E...
December 8, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29229274/team-approach-to-manage-difficult-to-treat-tb-cases-experiences-in-europe-and-beyond
#20
L D'Ambrosio, G Bothamley, J A Caminero Luna, R Duarte, L Guglielmetti, M Muñoz Torrico, M C Payen, N Saavedra Herrera, M A Salazar Lezama, A Skrahina, M Tadolini, S Tiberi, N Veziris, G B Migliori
As recommended by the World Health Organization (WHO), optimal management of MDR-TB cases can be ensured by a multi-speciality consultation body known as 'TB Consilium'. This body usually includes different medical specialities, competences and perspectives (e.g., clinical expertise both for adults and children; surgical, radiological and public health expertise; psychological background and nursing experience, among others), thus lowering the risk of making mistakes - or managing the patients inappropriately, in order to improve their clinical outcomes...
December 8, 2017: Revista Portuguesa de Pneumologia
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