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https://www.readbyqxmd.com/read/29045912/the-lived-experience-of-first-year-undergraduate-student-nurses-a-hermeneutic-phenomenological-study
#1
Debra J Porteous, Alison Machin
INTRODUCTION: This study gives insight into the experiences and perceptions of one group of undergraduate nursing students as they make the transition into Higher Education and the nursing profession, during the first year, of their three-year programme. Research has shown that first year undergraduate experience is complex and challenging for any student. For undergraduate nursing students, the process of achieving additional professional practice competencies required for United Kingdom nursing registration adds additional responsibility and potentially, more pressure...
October 3, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29045632/patient-general-practitioner-and-oncologist-views-regarding-long-term-cancer-shared-care
#2
Heike Schütze, Melvin Chin, David Weller, Mark F Harris
Background: The rising incidence of cancer and increasing number of cancer survivors place competing demands on specialist oncology clinics. This has led to a need to consider collaborative care between primary and secondary care for the long-term post-treatment care of cancer survivors. Objective: To explore the views of breast and colorectal cancer survivors, their oncologist and GP about GPs taking a more active role in long-term cancer follow-up care. Methods: Semi-structured interviews using a thematic analysis framework...
October 14, 2017: Family Practice
https://www.readbyqxmd.com/read/29045060/competency-assessment-form-to-improve-feedback
#3
Karen E Hauer, Holly Nishimura, Diego Dubon, Arianne Teherani, Christy Boscardin
BACKGROUND: In-training evaluation reports are a commonly used assessment method for clinical learners that can characterise the development of competence in essential domains of practice. Strategies to increase the usefulness and specificity of written narrative comments about learner performance in these reports are needed to guide their learning. Soliciting narrative comments by competency domain from supervising doctors on in-training evaluation reports could improve the quality of written feedback to students...
October 18, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/29044745/solvent-effect-on-the-photoinduced-structural-change-of-a-phosphorescent-molecular-butterfly
#4
Yingzhong Ma, Chenkun Zhou, Benjamin Doughty, Davis C Easley, Justin Deterding, Biwu Ma
Photoinduced structural changes (PSC) is one of the fundamental excited-state dynamical processes, and yet often very challenging to distinguish from competing electronic excited-state relaxation channels having similar or even comparable timescales. Here, we report a detailed study on the PSC of a pyrazolate bridged platinum(II) binuclear complex, a molecular butterfly, using time-correlated single photon counting measurements at different wavelengths and sample temperatures. Analysis of the results obtained using dichloromethane (DCM) and ethylene carbonate (EC) as solvents enabled us to reveal an unexpected, strong solvent effect on the PSC processes...
October 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29044185/structural-analysis-of-variant-of-helicobacter-pylori-motb-in-its-activated-form-engineered-as-chimera-of-motb-and-leucine-zipper
#5
Daniel A Andrews, Yuri E Nesmelov, Matthew C Wilce, Anna Roujeinikova
Rotation of the bacterial flagellum is powered by a proton influx through the peptidoglycan (PG)-tethered stator ring MotA/B. MotA and MotB form an inner-membrane complex that does not conduct protons and does not bind to PG until it is inserted into the flagellar motor. The opening of the proton channel involves association of the plug helices in the periplasmic region of the MotB dimer into a parallel coiled coil. Here, we have characterised the structure of a soluble variant of full-length Helicobacter pylori MotB in which the plug helix was engineered to be locked in a parallel coiled coil state, mimicking the open state of the stator...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044122/wind-loads-and-competition-for-light-sculpt-trees-into-self-similar-structures
#6
Christophe Eloy, Meriem Fournier, André Lacointe, Bruno Moulia
Trees are self-similar structures: their branch lengths and diameters vary allometrically within the tree architecture, with longer and thicker branches near the ground. These tree allometries are often attributed to optimisation of hydraulic sap transport and safety against elastic buckling. Here, we show that these allometries also emerge from a model that includes competition for light, wind biomechanics and no hydraulics. We have developed MECHATREE, a numerical model of trees growing and evolving on a virtual island...
October 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/29042875/current-challenges-and-future-opportunities-for-child-and-adolescent-psychiatry-in-japan
#7
REVIEW
Masaru Tateno, Takahiko Inagaki, Takuya Saito, Anthony P S Guerrero, Norbert Skokauskas
Japan has been facing a serious shortfall of child and adolescent psychiatric workforce relative to increasing service needs. Likely because of a combination of limited workforce supply and limited trust or perception of effectiveness, mental health services are under-utilized by the educational and child welfare systems. Child and adolescent psychiatry (CAP) has not been a formally established specialty in Japan. The lack of basic structure in the specialty most likely contributes to a lack of training facilities, limited exposure to and interest in the specialty, and hence an inadequate workforce...
September 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29042621/postnatal-development-of-the-murine-notochord-remnants-quantified-by-high-resolution-contrast-enhanced-microct
#8
Sameer Bhalla, Kevin H Lin, Simon Y Tang
The notochord gives rise to spinal segments during development, and it becomes embedded within the nucleus pulposus of the intervertebral disc (IVD) during maturation. The disruption of the notochord band has been observed with IVD degeneration. Since the mechanical competence of the IVD relies on its structural constituents, defining the structure of the notochord during aging is critical for investigations relating to IVD function and homeostasis. The assessment and imaging of the notochord has classically relied on histological techniques, which introduces sectioning artifacts during preparation and spatial biases...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042496/structural-basis-of-type-2-secretion-system-engagement-between-the-inner-and-outer-bacterial-membranes
#9
Iain D Hay, Matthew J Belousoff, Trevor Lithgow
Sophisticated nanomachines are used by bacteria for protein secretion. In Gram-negative bacteria, the type 2 secretion system (T2SS) is composed of a pseudopilus assembly platform in the inner membrane and a secretin complex in the outer membrane. The engagement of these two megadalton-sized complexes is required in order to secrete toxins, effectors, and hydrolytic enzymes. Pseudomonas aeruginosa has at least two T2SSs, with the ancestral nanomachine having a secretin complex composed of XcpQ. Until now, no high-resolution structural information was available to distinguish the features of this Pseudomonas-type secretin, which varies greatly in sequence from the well-characterized Klebsiella-type and Vibrio-type secretins...
October 17, 2017: MBio
https://www.readbyqxmd.com/read/29041338/semi-analytical-approach-to-supermode-spatial-solitons-formation-in-nematic-liquid-crystals
#10
Pawel S Jung, Wieslaw Krolikowski, Urszula A Laudyn, Miroslaw A Karpierz, Marek Trippenbach
We study light propagation in nematic liquid crystals in the context of spatial optical solitons formation. We propose a simple analytical model with multiplicative nonlinearity, which represents (qualitatively) the liquid crystal response by comprising the competition between focusing (reorientational) and defocusing (thermal) nonlocal nonlinearities. We show that at sufficiently high input power the interplay between both nonlinearities leads to the formations of two-peak solitons, which represent supermodes of the self-induced extended waveguide structure...
October 2, 2017: Optics Express
https://www.readbyqxmd.com/read/29040603/mitosis-specific-acetylation-tunes-ran-effector-binding-for-chromosome-segregation
#11
Xiaoling Bao, Heng Liu, Xing Liu, Ke Ruan, Yonghui Zhang, Zhiyong Zhang, Qi Hu, Ying Liu, Saima Akram, Jiahai Zhang, Qingguo Gong, Wenwen Wang, Xiao Yuan, Jian Li, Lingli Zhao, Zhen Dou, Ruijun Tian, Xuebiao Yao, Jihui Wu, Yunyu Shi
Stable transmission of genetic information during cell division requires faithful mitotic spindle assembly and chromosome segregation. The Ran GTPase plays a key role in mitotic spindle assembly. However, how the generation of a chemical gradient of Ran-GTP at the spindle is coupled to mitotic post-translational modifications has never been characterized. Here, we solved the complex structure of Ran with the nucleotide release factor Mog1 and delineated a novel mitosis-specific acetylation-regulated Ran-Mog1 interaction during chromosome segregation...
October 6, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29040274/a-quadratically-regularized-functional-canonical-correlation-analysis-for-identifying-the-global-structure-of-pleiotropy-with-ngs-data
#12
Nan Lin, Yun Zhu, Ruzong Fan, Momiao Xiong
Investigating the pleiotropic effects of genetic variants can increase statistical power, provide important information to achieve deep understanding of the complex genetic structures of disease, and offer powerful tools for designing effective treatments with fewer side effects. However, the current multiple phenotype association analysis paradigm lacks breadth (number of phenotypes and genetic variants jointly analyzed at the same time) and depth (hierarchical structure of phenotype and genotypes). A key issue for high dimensional pleiotropic analysis is to effectively extract informative internal representation and features from high dimensional genotype and phenotype data...
October 17, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29040265/analysis-of-peripheral-b-cells-and-autoantibodies-against-the-anti-nicotinic-acetylcholine-receptor-derived-from-patients-with-myasthenia-gravis-using-single-cell-manipulation-tools
#13
Tomohiro Makino, Ryuichi Nakamura, Maki Terakawa, Satoshi Muneoka, Kazuhiro Nagahira, Yuriko Nagane, Jyoji Yamate, Masakatsu Motomura, Kimiaki Utsugisawa
The majority of patients with myasthenia gravis (MG), an organ-specific autoimmune disease, harbor autoantibodies that attack the nicotinic acetylcholine receptor (nAChR-Abs) at the neuromuscular junction of skeletal muscles, resulting in muscle weakness. Single cell manipulation technologies coupled with genetic engineering are very powerful tools to examine T cell and B cell repertoires and the dynamics of adaptive immunity. These tools have been utilized to develop mAbs in parallel with hybridomas, phage display technologies and B-cell immortalization...
2017: PloS One
https://www.readbyqxmd.com/read/29039614/substitutions-of-rtl228-and-or-l229-are-involved-in-the-regulation-of-replication-and-hbsag-secretion-in-hepatitis-b-virus-and-do-not-affect-susceptibility-to-nucleos-t-ide-analogs
#14
Bo Qin, Yechao Zhou, Guozhong Zhou, Xiuping Xu, Yanan Wang, Jinkun Chen
Nucleos(t)ide analogs (NAs) are widely used in the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV). The mutation L210W of HIV‑1 reverse transcriptase (RT) is one of the six principal mutations which confer in vivo resistance to zidovudine. Due to the similar 3D‑structure and high conservation between HIV‑RT and HBV‑RT, the present study aimed to clarify whether corresponding mutations in HBV may decrease its susceptibility to relevant NAs. Mutations including rtL228C/W, rtL229W and rtL228W/L229W were introduced into a HBV replication competent plasmid by fusion polymerase chain reaction...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038804/insights-into-the-interfacial-structure-function-of-poly-ethylene-glycol-decorated-peptide-stabilised-nanoscale-emulsions
#15
Hossam H Tayeb, Stefania Piantavigna, Christopher B Howard, Amanda Nouwens, Stephen M Mahler, Anton P J Middelberg, Lizhong He, Stephen A Holt, Frank Sainsbury
The interfacial properties of nanoscale materials have profound influence on biodistribution and stability as well as the effectiveness of sophisticated surface-encoded properties such as active targeting to cell surface receptors. Tailorable nanocarrier emulsions (TNEs) are a novel class of oil-in-water emulsions stabilised by molecularly-engineered biosurfactants that permit single-pot stepwise surface modification with related polypeptides that may be chemically conjugated or genetically fused to biofunctional moieties...
October 17, 2017: Soft Matter
https://www.readbyqxmd.com/read/29038132/provider-perspectives-of-high-quality-pediatric-hospital-to-home-transitions-for-children-and-youth-with-chronic-disease
#16
Carolyn C Foster, Elizabeth Jacob-Files, Kimberly C Arthur, Stephanie A Hillman, Todd C Edwards, Rita Mangione-Smith
OBJECTIVE: The objective of this study was to describe health care providers' and hospital administrators' perspectives on how to improve pediatric hospital-to-home transitions for children and youth with chronic disease (CYCD). METHODS: Focus groups and key informant interviews of inpatient attending physicians, primary care physicians, pediatric residents, nurses, care coordinators, and social workers were conducted at a tertiary care children's hospital. Key informant interviews were performed with hospital administrators...
October 16, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29037415/dental-phenotypic-shape-variation-supports-a-multiple-dispersal-model-for-anatomically-modern-humans-in-southeast-asia
#17
Julien Corny, Manon Galland, Marta Arzarello, Anne-Marie Bacon, Fabrice Demeter, Dominique Grimaud-Hervé, Charles Higham, Hirofumi Matsumura, Lan Cuong Nguyen, Thi Kim Thuy Nguyen, Viet Nguyen, Marc Oxenham, Thongsa Sayavongkhamdy, François Sémah, Laura L Shackelford, Florent Détroit
The population history of anatomically modern humans (AMH) in Southeast Asia (SEA) is a highly debated topic. The impact of sea level variations related to the Last Glacial Maximum (LGM) and the Neolithic diffusion on past population dispersals are two key issues. We have investigated competing AMH dispersal hypotheses in SEA through the analysis of dental phenotype shape variation on the basis of very large archaeological samples employing two complementary approaches. We first explored the structure of between- and within-group shape variation of permanent human molar crowns...
November 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/29034059/lcn-a-random-graph-mixture-model-for-community-detection-in-functional-brain-networks
#18
Christopher Bryant, Hongtu Zhu, Mihye Ahn, Joseph Ibrahim
The aim of this article is to develop a Bayesian random graph mixture model (RGMM) to detect the latent class network (LCN) structure of brain connectivity networks and estimate the parameters governing this structure. The use of conjugate priors for unknown parameters leads to efficient estimation, and a well-known nonidentifiability issue is avoided by a particular parameterization of the stochastic block model (SBM). Posterior computation proceeds via an efficient Markov Chain Monte Carlo algorithm. Simulations demonstrate that LCN outperforms several other competing methods for community detection in weighted networks, and we apply our RGMM to estimate the latent community structures in the functional resting brain networks of 185 subjects from the ADHD-200 sample...
2017: Statistics and its Interface
https://www.readbyqxmd.com/read/29033957/reacquisition-of-new-meristematic-sites-determines-the-development-of-a-new-organ-the-cecidomyiidae-gall-on-copaifera-langsdorffii-desf-fabaceae
#19
Renê G S Carneiro, Rosy M S Isaias, Ana S F P Moreira, Denis C Oliveira
The development of gall shapes has been attributed to the feeding behavior of the galling insects and how the host tissues react to galling stimuli, which ultimately culminate in a variable set of structural responses. A superhost of galling herbivores, Copaifera langsdorffii, hosts a bizarre "horn-shaped" leaflet gall morphotype induced by an unidentified species of Diptera: Cecidomyiidae. By studying the development of this gall morphotype under the anatomical and physiological perspectives, we demonstrate the symptoms of the Cecidomyiidae manipulation over plant tissues, toward the cell redifferentiation and tissue neoformation...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29033881/age-and-gender-differences-in-facial-attractiveness-but-not-emotion-resemblance-contribute-to-age-and-gender-stereotypes
#20
Rocco Palumbo, Reginald B Adams, Ursula Hess, Robert E Kleck, Leslie Zebrowitz
Considerable research has shown effects of facial appearance on trait impressions and group stereotypes. We extended those findings in two studies that investigated the contribution of resemblance to emotion expressions and attractiveness to younger adults (YA) and older adults (OA) age and gender stereotypes on the dimensions of warmth and competence. Using connectionist modeling of facial metrics of 240 neutral younger and older faces, Study 1 found that, neutral expression older faces or female faces showed greater structural resemblance to happy expressions and less resemblance to angry expressions than did younger or male faces, respectively...
2017: Frontiers in Psychology
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