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https://www.readbyqxmd.com/read/29453450/insights-into-the-inhibitory-mechanisms-of-nadh-on-the-%C3%AE-%C3%AE-heterodimer-of-human-nad-dependent-isocitrate-dehydrogenase
#1
Yabing Liu, Lejia Hu, Tengfei Ma, Jun Yang, Jianping Ding
Human NAD-dependent isocitrate dehydrogenase (NAD-IDH) catalyzes the oxidative decarboxylation of isocitrate in the citric acid cycle. In the α 2 βγ heterotetramer of NAD-IDH, the γ subunit plays the regulatory role and the β subunit the structural role. Previous biochemical data have shown that mammalian NAD-IDHs can be inhibited by NADH; however, the molecular mechanism is unclear. In this work, we show that the αβ, αγ and α 2 βγ enzymes of human NAD-IDH can be inhibited by NADH, and further determine the crystal structure of the αγ heterodimer bound with an Mg 2+ and an NADH at the active site and an NADH at the allosteric site, which resembles that of the inactive α Mg γ heterodimer...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452416/early-and-midlife-predictors-of-wisdom-and-subjective-well-being-in-old-age
#2
Monika Ardelt, Kathryn R Gerlach, George E Vaillant
Objectives: We explored whether wisdom and well-being in old age are the result of early personality traits related to personality growth or personality adjustment, respectively, or successful human development as outlined by Erikson's stage theory and the life course paradigm. Method: Structural equation models were applied to analyze 60-year longitudinal data of 98 white male Harvard graduates born between 1915 and 1924. Different sets of judges rated the men's childhood and adolescence, early adult personality, and midlife generativity...
February 14, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29450991/mass-spectrometry-based-fast-photochemical-oxidation-of-proteins-fpop-for-higher-order-structure-characterization
#3
Ke Sherry Li, Liuqing Shi, Michael L Gross
Assessment of protein structure and interaction is crucial for understanding protein structure/function relationships. Compared to high-resolution structural tools, including X-ray crystallography, nuclear magnetic resonance (NMR), and cryo-EM, and traditional low-resolution methods, such as circular dichroism, UV-vis, and florescence spectroscopy, mass spectrometry (MS)-based protein footprinting affords medium-to-high resolution (i.e., regional and residue-specific insights) by taking advantage of proteomics methods focused on the primary structure...
February 16, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29450922/anisotropic-thermal-and-guest-induced-responses-of-an-ultramicroporous-framework-with-rigid-linkers
#4
Josie E Auckett, Samuel G Duyker, Ekaterina I Izgorodina, Chris S Hawes, David R Turner, Stuart R Batten, Vanessa Kate Peterson
The interdependent effects of temperature and guest uptake on the structure of the ultramicroporous metal-organic framework [Cu3(cdm)4] (cdm = C(CN)2(CONH2)-) are explored in detail using in situ neutron scattering and density functional theory calculations. The tetragonal lattice displays an anisotropic thermal response related to a hinged "lattice-fence" mechanism, unusual for this topology, which is facilitated by pivoting of the rigid cdm anion about the Cu nodes. Calculated pore size metrics clearly illustrate the potential for temperature-mediated adsorption in ultramicroporous frameworks due to thermal fluctuations of the pore diameter near the value of the target guest kinetic diameter, though in [Cu3(cdm)4] this is counteracted by a competing contraction of the pore with increasing temperature as a result of the anisotropic lattice response...
February 16, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29450447/interplay-among-psychopathologic-variables-personal-resources-context-related-factors-and-real-life-functioning-in-individuals-with-schizophrenia-a-network-analysis
#5
Silvana Galderisi, Paola Rucci, Brian Kirkpatrick, Armida Mucci, Dino Gibertoni, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Gregory P Strauss, Eugenio Aguglia, Antonello Bellomo, Martino Belvederi Murri, Paola Bucci, Bernardo Carpiniello, Anna Comparelli, Alessandro Cuomo, Domenico De Berardis, Liliana Dell'Osso, Fabio Di Fabio, Barbara Gelao, Carlo Marchesi, Palmiero Monteleone, Cristiana Montemagni, Giulia Orsenigo, Francesca Pacitti, Rita Roncone, Paolo Santonastaso, Alberto Siracusano, Annarita Vignapiano, Antonio Vita, Patrizia Zeppegno, Mario Maj
Importance: Enhanced understanding of factors associated with symptomatic and functional recovery is instrumental to designing personalized treatment plans for people with schizophrenia. To date, this is the first study using network analysis to investigate the associations among cognitive, psychopathologic, and psychosocial variables in a large sample of community-dwelling individuals with schizophrenia. Objective: To assess the interplay among psychopathologic variables, cognitive dysfunctions, functional capacity, personal resources, perceived stigma, and real-life functioning in individuals with schizophrenia, using a data-driven approach...
February 14, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29448794/short-time-dynamics-of-lysozyme-solutions-with-competing-short-range-attraction-and-long-range-repulsion-experiment-and-theory
#6
Jonas Riest, Gerhard Nägele, Yun Liu, Norman J Wagner, P Douglas Godfrin
Recently, atypical static features of microstructural ordering in low-salinity lysozyme protein solutions have been extensively explored experimentally and explained theoretically based on a short-range attractive plus long-range repulsive (SALR) interaction potential. However, the protein dynamics and the relationship to the atypical SALR structure remain to be demonstrated. Here, the applicability of semi-analytic theoretical methods predicting diffusion properties and viscosity in isotropic particle suspensions to low-salinity lysozyme protein solutions is tested...
February 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29448771/dark-states-and-delocalization-competing-effects-of-quantum-coherence-on-the-efficiency-of-light-harvesting-systems
#7
Zixuan Hu, Gregory S Engel, Fahhad H Alharbi, Sabre Kais
Natural light harvesting systems exploit electronic coupling of identical chromophores to generate efficient and robust excitation transfer and conversion. Dark states created by strong coupling between chromophores in the antenna structure can significantly reduce radiative recombination and enhance energy conversion efficiency. Increasing the number of the chromophores increases the number of dark states and the associated enhanced energy conversion efficiency yet also delocalizes excitations away from the trapping center and reduces the energy conversion rate...
February 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29447820/how-does-a-bilingual-environment-affect-the-results-in-children-with-cochlear-implants-compared-to-monolingual-matched-children-an-italian-follow-up-study
#8
Francesca Forli, Giada Giuntini, Annalisa Ciabotti, Luca Bruschini, Ulrika Löfkvist, Stefano Berrettini
OBJECTIVES: To compare the results after cochlear implantation achieved by monolingual and bilingual deaf children implanted at our Institution, with the aim of understanding if there are any differences between the two groups and if there is a correlation between the outcomes and some patients' variables. METHODS: The study group was composed by 14 bilingual deaf children and the control group by the same number of monolingual children implanted at our Institution...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447156/west-nile-and-st-louis-encephalitis-viral-genetic-determinants-of-avian-host-competence
#9
Payal D Maharaj, Angela M Bosco-Lauth, Stanley A Langevin, Michael Anishchenko, Richard A Bowen, William K Reisen, Aaron C Brault
West Nile virus (WNV) and St. Louis encephalitis (SLEV) virus are enzootically maintained in North America in cycles involving the same mosquito vectors and similar avian hosts. However, these viruses exhibit dissimilar viremia and virulence phenotypes in birds: WNV is associated with high magnitude viremias that can result in mortality in certain species such as American crows (AMCRs, Corvus brachyrhynchos) whereas SLEV infection yields lower viremias that have not been associated with avian mortality. Cross-neutralization of these viruses in avian sera has been proposed to explain the reduced circulation of SLEV since the introduction of WNV in North America; however, in 2015, both viruses were the etiologic agents of concurrent human encephalitis outbreaks in Arizona, indicating the need to re-evaluate host factors and cross-neutralization responses as factors potentially affecting viral co-circulation...
February 15, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29444674/the-gendered-experience-with-respect-to-health-seeking-behaviour-in-an-urban-slum-of-kolkata-india
#10
Moumita Das, Federica Angeli, Anja J S M Krumeich, Onno C P van Schayck
BACKGROUND: Empirical evidence shows that the relationship between health-seeking behaviour and diverse gender elements, such as gendered social status, social control, ideology, gender process, marital status and procreative status, changes across settings. Given the high relevance of social settings, this paper intends to explore how gender elements interact with health-seeking practices among men and women residing in an Indian urban slum, in consideration of the unique socio-cultural context that characterises India's slums...
February 14, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29444229/bioprosthetic-mitral-valve-replacement-in-patients-aged-65%C3%A2-years-or-younger-long-term-outcomes-with-the-carpentier-edwards-perimount-pericardial-valve
#11
Thierry Bourguignon, Fabien Espitalier, Clémence Pantaleon, Emmanuelle Vermes, Jean Marc El-Arid, Claudia Loardi, Elias Karam, Pascal Candolfi, Fabrice Ivanes, Michel Aupart
OBJECTIVES: Mitral valve replacement using a bioprosthesis remains controversial in young patients because data on long-term outcomes are missing. This study evaluated the long-term results of the PERIMOUNT pericardial mitral bioprosthesis in patients aged 65 years or younger. METHODS: From 1984 to 2010, 148 Carpentier-Edwards PERIMOUNT mitral bioprostheses were implanted in 148 patients aged 65 years or younger. Baseline clinical, perioperative and follow-up data were recorded prospectively...
February 12, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29444132/a-linear-bi-level-multi-objective-program-for-optimal-allocation-of-water-resources
#12
Ijaz Ahmad, Fan Zhang, Junguo Liu, Muhammad Naveed Anjum, Muhammad Zaman, Muhammad Tayyab, Muhammad Waseem, Hafiz Umar Farid
This paper presents a simple bi-level multi-objective linear program (BLMOLP) with a hierarchical structure consisting of reservoir managers and several water use sectors under a multi-objective framework for the optimal allocation of limited water resources. Being the upper level decision makers (i.e., leader) in the hierarchy, the reservoir managers control the water allocation system and tend to create a balance among the competing water users thereby maximizing the total benefits to the society. On the other hand, the competing water use sectors, being the lower level decision makers (i...
2018: PloS One
https://www.readbyqxmd.com/read/29443400/barriers-to-nutrition-intervention-for-patients-with-a-traumatic-brain-injury-views-and-attitudes-of-medical-and-nursing-practitioners-in-the-acute-care-setting
#13
Lee-Anne Chapple, Marianne Chapman, Natalie Shalit, Andrew Udy, Adam Deane, Lauren Williams
BACKGROUND: Nutrition delivered to patients with a traumatic brain injury (TBI) is typically below prescribed amounts. While the dietitian plays an important role in the assessment and provision of nutrition needs, they are part of a multidisciplinary team. The views and attitudes of medical and nursing practitioners are likely to be crucial to implementation of nutrition to patients with TBI, but there is limited information describing these. METHODS: A qualitative exploratory approach was used to explore the views and attitudes of medical and nursing practitioners on nutrition for patients with TBI...
February 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29442164/diagnostic-flexible-pharyngo-laryngoscopy-development-of-a-procedure-specific-assessment-tool-using-a-delphi-methodology
#14
Jacob Melchiors, Mikael Johannes Vuokko Henriksen, Frederik G Dikkers, Javier Gavilán, J Pieter Noordzij, Marvin P Fried, Daniel Novakovic, Johannes Fagan, Birgitte W Charabi, Lars Konge, Christian von Buchwald
PURPOSE: Proper training and assessment of skill in flexible pharyngo-laryngoscopy are central in the education of otorhinolaryngologists. To facilitate an evidence-based approach to curriculum development in this field, a structured analysis of what constitutes flexible pharyngo-laryngoscopy is necessary. Our aim was to develop an assessment tool based on this analysis. METHODS: We conducted an international Delphi study involving experts from twelve countries in five continents...
February 13, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29441815/the-secret-drama-at-the-patient-s-bedside-refusal-of-treatment-because-of-the-practitioner-s-ethnic-identity-the-medical-staff-s-point-of-view
#15
Ariela Popper-Giveon, Yael Keshet
Patients' refusal of treatment based on the practitioner's ethnic identity reveals a clash of values: neutrality in medicine versus patient-centered care. Taking the Israeli-Palestinian conflict into account, this article aims at examining Israeli health care professionals' points of view concerning patients' refusal of treatment because of a practitioner's ethnic identity. Fifty in-depth interviews were conducted with 10 managers and 40 health care professionals, Jewish and Arab, employed at 11 public hospitals...
February 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29441061/profiling-of-human-molecular-pathways-affected-by-retrotransposons-at-the-level-of-regulation-by-transcription-factor-proteins
#16
Daniil Nikitin, Dmitry Penzar, Andrew Garazha, Maxim Sorokin, Victor Tkachev, Nicolas Borisov, Alexander Poltorak, Vladimir Prassolov, Anton A Buzdin
Endogenous retroviruses and retrotransposons also termed retroelements (REs) are mobile genetic elements that were active until recently in human genome evolution. REs regulate gene expression by actively reshaping chromatin structure or by directly providing transcription factor binding sites (TFBSs). We aimed to identify molecular processes most deeply impacted by the REs in human cells at the level of TFBS regulation. By using ENCODE data, we identified ~2 million TFBS overlapping with putatively regulation-competent human REs located in 5-kb gene promoter neighborhood (~17% of all TFBS in promoter neighborhoods; ~9% of all RE-linked TFBS)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29440734/dynamics-of-starvation-and-recovery-predict-extinction-risk-and-both-damuth-s-law-and-cope-s-rule
#17
Justin D Yeakel, Christopher P Kempes, Sidney Redner
The eco-evolutionary dynamics of species are fundamentally linked to the energetic constraints of their constituent individuals. Of particular importance is the interplay between reproduction and the dynamics of starvation and recovery. To elucidate this interplay, here we introduce a nutritional state-structured model that incorporates two classes of consumers: nutritionally replete, reproducing consumers, and undernourished, nonreproducing consumers. We obtain strong constraints on starvation and recovery rates by deriving allometric scaling relationships and find that population dynamics are typically driven to a steady state...
February 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29440271/phosphorylated-immunoreceptor-tyrosine-based-activation-motifs-and-integrin-cytoplasmic-domains-activate-spleen-tyrosine-kinase-via-distinct-mechanisms
#18
Lina Antenucci, Vesa P Hytönen, Jari Ylänne
Spleen tyrosine kinase (Syk) is involved in cellular adhesion and also in the activation and development of hematopoietic cells. Syk activation induced by genomic rearrangement has been linked to certain T-cell lymphomas, and Syk inhibitors have been shown to prolong survival of patients with B-cell lineage malignancies. Syk is activated either by its interaction with a double-phosphorylated Immunoreceptor Tyrosine-based Activation Motif (pITAM), which induces rearrangements in the Syk structure, or by the phosphorylation of specific tyrosine residues...
February 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29440172/a-distinct-oncogenerative-multinucleated-cancer-cell-serves-as-a-source-of-stemness-and-tumor-heterogeneity
#19
David Diaz-Carballo, Sahitya Saka, Jacqueline Klein, Tobias Rennkamp, Ali Haydar Acikelli, Sascha Malak, Holger Jastrow, Gunther Wennemuth, Clemens B Tempfer, Inge Schmitz, Andrea Tannapfel, Dirk Strumberg
The effects of anticancer treatments on cell heterogeneity and their proliferative potential play an important role in tumor persistence and metastasis. However, little is known about de-polyploidization, cell fate, and physiological stemness of the resulting cell populations. Here we describe a distinctive cell type termed "pregnant" P1 cells found within chemotherapy refractory ovarian tumors, which generate and gestate daughter generation Gn-cells intracytoplasmically. Release of Gn-cells occurred by ejection through crevices in P1 cell membrane by body contractions or using a funiculus-like structure...
February 12, 2018: Cancer Research
https://www.readbyqxmd.com/read/29439568/lessons-learned-from-luminous-luciferins-and-latent-luciferases
#20
Stephen C Miller, David M Mofford, Spencer T Adams
Compared to the broad palette of fluorescent molecules, there are relatively few structures that are competent to support bioluminescence. Here we focus on recent advances in the development of luminogenic substrates for firefly luciferase. The scope of this light-emitting chemistry has been found to extend well beyond the natural substrate, and to include enzymes incapable of luciferase activity with D-luciferin. The broadening range of luciferin analogues and evolving insight into the bioluminescent reaction offer new opportunities for the construction of powerful optical reporters of use in live cells and animals...
February 13, 2018: ACS Chemical Biology
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