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resveratrol and hcc

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https://www.readbyqxmd.com/read/27748853/pterostilbene-inhibits-hepatocellular-carcinoma-through-p53-sod2-ros-mediated-mitochondrial-apoptosis
#1
Liying Guo, Kai Tan, Hao Wang, Xuan Zhang
Hepatocellular carcinoma (HCC) is one of the most common malignancies and the second cause of cancer-related deaths around the world. Pterostilbene (PTE), is a natural analog of resveratrol, possessing diverse pharmacological activities. In the present study, we aimed to examine the effect of PTE on tumor growth in mouse models of HCC and to elucidate the possible molecular mechanism in vivo and in vitro. We showed that PTE dose-dependently suppressed tumor growth in mice induced by diethylnitrosamine plus carbon tetrachloride, as evidenced by a decrease in the number of tumors and in the maximum size of the tumors...
October 5, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27338546/alcohol-modulates-autophagy-and-apoptosis-in-pig-liver-tissue
#2
Brittany A Potz, Isabella J Lawandy, Richard T Clements, Frank W Sellke
BACKGROUND: Autophagy serves as a cellular protective mechanism against alcohol-induced tissue injury but excessive autophagy can also be detrimental leading to apoptosis. Our laboratory has previously shown that moderate alcohol consumption alters expression of proteins in the insulin signaling pathway and worsens glucose metabolism in the liver in a swine model of metabolic syndrome. We examined the effect of alcohol consumption on apoptosis and autophagy signaling in the liver in our clinically relevant animal model of chronic hypercholesterolemia...
June 1, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27266713/nutritional-epigenetics-and-the-prevention-of-hepatocellular-carcinoma-with-bioactive-food-constituents
#3
Fernando Salvador Moreno, Renato Heidor, Igor P Pogribny
Hepatocellular carcinoma (HCC) is an aggressive and life-threatening disease often diagnosed at intermediate or advanced stages, which substantially limits therapeutic approaches to its successful treatment. This indicates that the prevention of HCC may be the most promising strategy in reducing its incidence and mortality. Emerging evidence indicates that numerous nutrients and nonnutrient dietary bioactive components can reduce the occurrence and/or delay the development of HCC through modifications of deregulated epigenetic mechanisms...
July 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/26877244/drug-testing-and-flow-cytometry-analysis-on-a-large-number-of-uniform-sized-tumor-spheroids-using-a-microfluidic-device
#4
Bishnubrata Patra, Chien-Chung Peng, Wei-Hao Liao, Chau-Hwang Lee, Yi-Chung Tung
Three-dimensional (3D) tumor spheroid possesses great potential as an in vitro model to improve predictive capacity for pre-clinical drug testing. In this paper, we combine advantages of flow cytometry and microfluidics to perform drug testing and analysis on a large number (5000) of uniform sized tumor spheroids. The spheroids are formed, cultured, and treated with drugs inside a microfluidic device. The spheroids can then be harvested from the device without tedious operation. Due to the ample cell numbers, the spheroids can be dissociated into single cells for flow cytometry analysis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26709007/resveratrol-induces-apoptosis-through-modulation-of-the-akt-foxo3a-bim-pathway-in-hepg2-cells
#5
Mi-Hua Liu, Xiao-Long Lin, Jian Li, Jun He, Tian-Ping Tan, Shao-Jian Wu, Shan Yu, Li Chen, Jun Liu, Wei Tian, Yu-Dan Chen, Hong-Yun Fu, Cong Yuan, Yuan Zhang
Resveratrol is a polyphenolic compound found in wine, which is mainly produced by the grapevine and exerts chemopreventive effects against hepatocellular carcinoma. However, the underlying molecular mechanisms have remained to be fully elucidated. The present study assessed whether resveratrol-induced apoptosis was mediated via the activation of the forkhead box O3a (FoxO3a) transcription factor. It was demonstrated that resveratrol treatment induced apoptosis in HepG2 cells, and that this pro-apoptotic effect was accompanied with increases in the expression of apoptotic protein Bim...
February 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26498332/resveratrol-ameliorates-hepatic-steatosis-and-inflammation-in-methionine-choline-deficient-diet-induced-steatohepatitis-through-regulating-autophagy
#6
Guiyuan Ji, Yuqi Wang, Yingxun Deng, Xin Li, Zhuoqin Jiang
BACKGROUND: Non-alcoholic steatohepatitis (NASH) is one of the leading causes of chronic liver disease that can progress to liver fibrosis, cirrhosis and eventually hepatocellular carcinoma. Resveratrol, a naturally occurring phytoalexin, is believed to have therapeutic effects on hepatic steatosis. However, the effect of resveratrol on NASH and the underlying mechanism is not fully illustrated. In the present study, we aimed to exam the effect of resveratrol on methionine/choline-deficient (MCD) diet or medium-induced hepatic steatosis, oxidation and inflammation, and to explore the possible mechanism...
2015: Lipids in Health and Disease
https://www.readbyqxmd.com/read/26436447/natural-antioxidants-for-non-alcoholic-fatty-liver-disease-molecular-targets-and-clinical-perspectives
#7
REVIEW
Federico Salomone, Justyna Godos, Shira Zelber-Sagi
Non-alcoholic steatohepatitis (NASH), the progressive form of non-alcoholic fatty liver disease (NAFLD), is emerging as a main health problem in industrialized countries. Lifestyle modifications are effective in the treatment of NAFLD; however, the long-term compliance is low. Therefore, several pharmacological treatments have been proposed but none has shown significant efficacy or long-term safety. Natural polyphenols are a heterogeneous class of polyphenolic compounds contained in vegetables, which are being proposed for the treatment of different metabolic disorders...
January 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/26189518/chemoprevention-against-hepatocellular-carcinoma
#8
Jun-Ichi Okano, Yuki Fujise, Ryo Abe, Ryu Imamoto, Yoshikazu Murawaki
Since the majority of hepatocellular carcinoma (HCC) arises from a background of chronic liver diseases caused by infection with hepatitis C virus (HCV) and hepatitis B virus (HBV), chemoprevention targeting patients at high risk of HCC is feasible. In this review article, we summarize current knowledge of chemoprevention against HCC mostly using phytochemicals which have less toxicity than pharmaceutical agents. We describe in vivo and in vitro evidence and proposed mechanisms of beneficial effects of several compounds on the liver, including acyclic retinoid (ACR), angiotensin-converting enzyme inhibitors (ACEIs), caffeine, capsaicin, cepharanthine (CEP), cinnamaldehyde, curcumin, diallyl sulfide (DAS), eicosapentaenoic acid (EPA), epigallocatechin-3-gallate (EGCG), genistein, lycopene, resveratrol, silymarin, sulforaphane (SFN), and xanthohumol (XN)...
August 2011: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/26077449/resveratrol-mediates-therapeutic-hepatic-effects-in-acquired-and-genetic-murine-models-of-iron-overload
#9
Subhash K Das, Jessica DesAulniers, Jason R B Dyck, Zamaneh Kassiri, Gavin Y Oudit
BACKGROUND & AIMS: Abnormal iron metabolism and hepatic iron-overload is a major cause of liver injury and in the development of chronic liver diseases. Iron-overload-mediated liver disease leads to end-stage cirrhosis and/or hepatocellular carcinoma. METHODS: Using a genetic hemochromatosis (hemojuvelin knockout mice) and non-genetic (secondary iron-overload) murine models of hepatic iron-overload, we elucidated the mechanism of hepatic iron injury and the therapeutic effects of resveratrol...
February 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/26052378/oxidative-stress-new-insights-on-the-association-of-non-alcoholic-fatty-liver-disease-and-atherosclerosis
#10
REVIEW
Licia Polimeni, Maria Del Ben, Francesco Baratta, Ludovica Perri, Fabiana Albanese, Daniele Pastori, Francesco Violi, Francesco Angelico
Non-alcoholic fatty liver disease (NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to non-alcoholic steatohepatitis (NASH), which may progress to fibrosis and more severe liver complications such as cirrhosis, hepatocellular carcinoma and liver mortality. NAFLD is strongly associated with obesity, insulin resistance, hypertension, and dyslipidaemia, and is now regarded as the liver manifestation of the metabolic syndrome...
June 8, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/25938543/by-reducing-hexokinase-2-resveratrol-induces-apoptosis-in-hcc-cells-addicted-to-aerobic-glycolysis-and-inhibits-tumor-growth-in-mice
#11
Weiqi Dai, Fan Wang, Jie Lu, Yujing Xia, Lei He, Kan Chen, Jingjing Li, Sainan Li, Tong Liu, Yuanyuan Zheng, Jianrong Wang, Wenxia Lu, Yuqing Zhou, Qin Yin, Huerxidan Abudumijiti, Rongxia Chen, Rong Zhang, Li Zhou, Zheng Zhou, Rong Zhu, Jing Yang, Chengfen Wang, Huawei Zhang, Yingqun Zhou, Ling Xu, Chuanyong Guo
Cancer cells exhibit an altered metabolic phenotype known as the aerobic glycolysis. The expression of HK2 changes the metabolic phenotype of cells to support cancerous growth. In the present study, we investigated the inhibitory effect of resveratrol on HK2 expression and hepatocellular carcinoma (HCC) cell glycolysis. Aerobic glycolysis was observed in four HCC cell lines compared to the normal hepatic cells. Resveratrol sensitized aerobic glycolytic HCC cells to apoptosis, and this effect was attenuated by glycolytic inhibitors...
May 30, 2015: Oncotarget
https://www.readbyqxmd.com/read/25909713/hepatitis-b-virus-pre-s2-mutant-induces-aerobic-glycolysis-through-mammalian-target-of-rapamycin-signal-cascade
#12
Chiao-Fang Teng, Wen-Chuan Hsieh, Han-Chieh Wu, Yih-Jyh Lin, Hung-Wen Tsai, Wenya Huang, Ih-Jen Su
Hepatitis B virus (HBV) pre-S2 mutant can induce hepatocellular carcinoma (HCC) via the induction of endoplasmic reticulum stress to activate mammalian target of rapamycin (MTOR) signaling. The association of metabolic syndrome with HBV-related HCC raises the possibility that pre-S2 mutant-induced MTOR activation may drive the development of metabolic disorders to promote tumorigenesis in chronic HBV infection. To address this issue, glucose metabolism and gene expression profiles were analyzed in transgenic mice livers harboring pre-S2 mutant and in an in vitro culture system...
2015: PloS One
https://www.readbyqxmd.com/read/25275043/synergistic-combinations-of-tanshinone-iia-and-trans-resveratrol-toward-cisplatin-comparable-cytotoxicity-in-hepg2-human-hepatocellular-carcinoma-cells
#13
Tung-Wu Chang, Chueh-Yu Lin, Yin-Jeh Tzeng, Huu-Sheng Lur
AIM: To determine the combinative effects of tanshinone IIA (Tan IIA) and trans-resveratrol (Resv) on cytotoxicity, apoptosis, cell-cycle arrest and DNA fragmentation in HepG2 human liver cancer cells. MATERIALS AND METHODS: Cytotoxicity was detected by the cell proliferation and cytotoxicity WST-1 assay. Cell-cycle arrest and apoptosis were determined using flow cytometry analysis. DNA fragments were separated by gel electrophoresis. RESULTS: Tan IIA and Resv at mixture ratios of 1/2:1/2 and 1/3:2/3 exerted synergistic cytotoxicity comparable to that of cisplatin...
October 2014: Anticancer Research
https://www.readbyqxmd.com/read/24892721/resveratrol-sensitizes-hepg2-cells-to-trail-induced-apoptosis
#14
Masahiko Tameda, Kazushi Sugimoto, Katsuya Shiraki, Yuji Inagaki, Suguru Ogura, Chika Kasai, Misao Yoneda, Ryuji Okamoto, Norihiko Yamamoto, Yoshiyuki Takei, Masaaki Ito, Tsutomu Nobori
Resveratrol is a natural polyphenol found in a wide variety of plants, including grapes, berries, and peanuts. Resveratrol can modulate a wide spectrum of molecular targets, including those involved in cancer signaling pathways. Here, we evaluated the role of resveratrol in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and examined the molecular mechanisms in the human hepatocellular carcinoma cell line HepG2. We used the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay to assess cell viability, flow cytometry to analyze cell cycle and apoptosis, and immunoblotting to detect protein expression...
October 2014: Anti-cancer Drugs
https://www.readbyqxmd.com/read/24522554/3-4-5-4-trans-tetramethoxystilbene-dmu-212-modulates-the-activation-of-nf-%C3%AE%C2%BAb-ap-1-and-stat3-transcription-factors-in-rat-liver-carcinogenesis-induced-by-initiation-promotion-regimen
#15
Michał Cichocki, Wanda Baer-Dubowska, Marcin Wierzchowski, Marek Murias, Jadwiga Jodynis-Liebert
It has been reported that methylated analog of resveratrol, 3,4,5,4'-trans-tetramethoxystilbene (DMU-212), demonstrates strong antiproliferative, and proapoptotic activity. The aim of this study was to evaluate the effect of DMU-212 on the activation of nuclear factor-κB (NF-κB), activator protein-1 (AP-1), and signal transducer and activator of transcription 3 (STAT3) transcription factors, using a two-stage model of rat hepatocarcinogenesis (HCC) in Wistar rats. Initiation was performed by a single intraperitoneal injection of N-nitrosodiethylamine (NDEA) (200 mg/kg) followed by promotion with phenobarbital (PB) (0...
June 2014: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/24473215/resveratrol-4-o-d-2-galloyl-glucopyranoside-isolated-from-polygonum-cuspidatum-exhibits-anti-hepatocellular-carcinoma-viability-by-inducing-apoptosis-via-the-jnk-and-erk-pathway
#16
Qichao Xie, Yupeng Yang, Zhiyi Wang, Fanglin Chen, Anmei Zhang, Chengcheng Liu
Resveratrol-4-O-D-(2'-galloyl)-glucopyranoside (RESG) is one of the active compounds isolated from Polygonum cuspidatum. The purpose of our present study was to investigate the anti-hepatocellular carcinoma effect of RESG in vitro and in vivo, and the possible mechanisms in vitro. In vitro, our results showed that RESG could significantly inhibit the human hepatocellular carcinoma viability in the MTT assay, in a dose- and time-dependent manner. Furthermore, our results demonstrated that RESG could induce SMMC-7721 cell apoptosis and activate caspases 3 and caspases 9 by using Annexin V-FITC staining and western blot, respectively...
2014: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/24064760/resveratrol-suppresses-the-stat3-signaling-pathway-and-inhibits-proliferation-of-high-glucose-exposed-hepg2-cells-partly-through-sirt1
#17
Yongguang Li, Wei Zhu, Jingbo Li, Mingya Liu, Meng Wei
Hepatocellular carcinoma is the most common type of liver cancer. The risk of hepatocellular carcinoma for type 2 diabetic patients is greater than that for non-diabetic individuals although the mechanism is unclear. The cancer suppressor resveratrol inhibits cancer cell proliferation partly through the STAT3 signaling pathway. However, the effects of resveratrol on STAT3 in high glucose-exposed HepG2 cells and the role of SIRT1 are not clear to date. The aim of the present study was to investigate the effects of resveratrol on STAT3 and SIRT1 regarding the proliferation of high glucose-exposed HepG2 cells...
December 2013: Oncology Reports
https://www.readbyqxmd.com/read/24023672/resveratrol-as-a-pan-hdac-inhibitor-alters-the-acetylation-status-of-histone-corrected-proteins-in-human-derived-hepatoblastoma-cells
#18
Sascha Venturelli, Alexander Berger, Alexander Böcker, Christian Busch, Timo Weiland, Seema Noor, Christian Leischner, Sabine Schleicher, Mascha Mayer, Thomas S Weiss, Stephan C Bischoff, Ulrich M Lauer, Michael Bitzer
The polyphenolic alcohol resveratrol has demonstrated promising activities for the prevention and treatment of cancer. Different modes of action have been described for resveratrol including the activation of sirtuins, which represent the class III histone deacetylases (HDACs). However, little is known about the activity of resveratrol on the classical HDACs of class I, II and IV, although these classes are involved in cancer development or progression and inhibitors of HDACs (HDACi) are currently under investigation as promising novel anticancer drugs...
2013: PloS One
https://www.readbyqxmd.com/read/23916858/chinese-herbal-medicine-derived-compounds-for-cancer-therapy-a-focus-on-hepatocellular-carcinoma
#19
REVIEW
Yangyang Hu, Shengpeng Wang, Xu Wu, Jinming Zhang, Ruie Chen, Meiwan Chen, Yitao Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Hepatocellular carcinoma (HCC) as the major histological subtype of primary liver cancer remains one of the most common malignancies worldwide. Due to the complicated molecular pathogenesis of HCC, the option for effective systemic treatment is quite limited. There exists a critical need to explore and evaluate possible alternative strategies for effective control of HCC. With a long history of clinical use, Chinese herbal medicine (CHM) is emerging as a noticeable choice for its multi-level, multi-target and coordinated intervention effects against HCC...
October 7, 2013: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/23446753/synergistic-anticancer-effects-of-curcumin-and-resveratrol-in-hepa1-6-hepatocellular-carcinoma-cells
#20
Qin Du, Bing Hu, Hong-Mei An, Ke-Ping Shen, Ling Xu, Shan Deng, Meng-Meng Wei
Hepatocellular carcinoma remains one of the most prevalent malignancies worldwide. Curcuma aromatica and Polygonum cuspidatum are one of the commonly used paired-herbs for liver cancer treatment. Curcumin and resveratrol are the major anticancer constituents of Curcuma aromatica and Polygonum cuspidatum, respectively. Curcumin and resveratrol have been found to exhibit a synergistic anticancer effect in colon cancer. However, the combined effect of curcumin and resveratrol against hepatocellular carcinoma remains unknown...
May 2013: Oncology Reports
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