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https://www.readbyqxmd.com/read/29666920/-unusual-coloboma-of-the-optic-disc
#1
J Lenk, L E Pillunat, E Matthé
A twelve-year old girl presented herself for a routine ophthalmologic examination in our clinic. Best-corrected visual acuity (BCVA) was 1.0 on both eyes. On funduscopic examination we saw a yellow round structure inferior to the optic nerve head. In optical coherence tomography (OCT) examination the structure showed cupping and opening of the Bruch membrane and retinal pigment epithelium (RPE). Visual field testing revealed an absolute scotoma right in the area were the abnormal coloboma was localized. We diagnosed a pseudo-doubling of the optic disk, which is a rare condition with just a few reports about it in the literature...
April 17, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29665674/hippo-signaling-circuit-and-divergent-tissue-growth-in-mammalian-eye
#2
Kyeong Hwan Moon, Jin Woo Kim
Vertebrate organ development is accompanied by demarcation of tissue compartments, which grow coordinately with their neighbors. Hence, perturbing the coordinative growth of neighboring tissue compartments frequently results in organ malformation. The growth of tissue compartments is regulated by multiple intercellular and intracellular signaling pathways, including the Hippo signaling pathway that limits the growth of various organs. In the optic neuroepithelial continuum, which is partitioned into the retina, retinal pigment epithelium (RPE) and ciliary margin (CM) during eye development, the Hippo signaling activity operates differentially, as it does in many tissues...
April 11, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29664989/choroidal-caverns-a-previously-unreported-optical-coherence-tomography-finding-in-best-vitelliform-dystrophy
#3
Adriano Carnevali, Riccardo Sacconi, Eleonora Corbelli, Lea Querques, Francesco Bandello, Giuseppe Querques
Best vitelliform macular dystrophy (VMD) is an autosomal dominant inherited dystrophy, most frequently caused by mutations in the BEST1 gene. The authors describe "choroidal caverns," a previously unreported optical coherence tomography finding in the choriocapillary and choroid of Best VMD. Histopathologic examination in eyes with Best VDM shows extensive deposition of lipofuscin in the retinal pigment epithelium (RPE) throughout the retina and accumulation of fibrillar material under the RPE and in the choroid...
April 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29660533/role-of-lysophosphatidic-acid-in-the-retinal-pigment-epithelium-and-photoreceptors
#4
Grace E Lidgerwood, Andrew J Morris, Alison Conquest, Maciej Daniszewski, Louise A Rooney, Shiang Y Lim, Damián Hernández, Helena H Liang, Penelope Allen, Paul P Connell, Robyn H Guymer, Alex W Hewitt, Alice Pébay
The human retina is a complex structure of organised layers of specialised cells that support the transmission of light signals to the visual cortex. The outermost layer of the retina, the retinal pigment epithelium (RPE) forms part of the blood retina barrier and is implicated in many retinal diseases. Lysophosphatidic acid (LPA) is a bioactive lipid exerting pleiotropic effects in various cell types, during development, normal physiology and disease. Its producing enzyme AUTOTAXIN (ATX) is highly expressed by the pigmented epithelia of the human eye, including the RPE...
April 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29657836/resistive-index-of-ophthalmic-artery-correlates-with-retinal-pigment-epithelial-alterations-on-spectral-domain-optical-coherence-tomography-in-diabetic-retinopathy
#5
Manila Khatri, Sandeep Saxena, Apjit Kaur, Shashi K Bhasker, Manoj Kumar, Carsten H Meyer
Background: Retinal pigment epithelium (RPE) plays a significant role in maintenance of integrity of retinal photoreceptors and choriocapillaries. RPE derives its blood supply through ophthalmic artery (OA) via choriocapillaries. RPE topographic alterations have been observed to be associated with severity of retinopathy. The present study was undertaken to assess the correlation between resistive index (RI) of the OA with RPE topographic alterations on Spectral-Domain optical coherence tomography (SD-OCT), to our knowledge, it is for the first time...
2018: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29653456/hesperidin-prevents-high-glucose-induced-damage-of-retinal-pigment-epithelial-cells
#6
Wayne Young Liu, Shorong-Shii Liou, Tang-Yao Hong, I-Min Liu
The present study aimed to determine whether hesperidin, a plant-based active flavanone found in citrus fruits, can prevent high glucose-induced retinal pigment epithelial (RPE) cell impairment. Cultured human RPE cells (ARPE-19) were exposed to a normal glucose concentration (5.5 mM) for 4 d and then soaked in either normal (5.5 mM) or high (33.3 mM) concentrations of D-glucose with or without different concentrations of hesperidin (10, 20, or 40 µM) for another 48 h. The survival rates of the cells were measured using a 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide reduction assay...
April 13, 2018: Planta Medica
https://www.readbyqxmd.com/read/29651346/choriocapillaris-loss-in-advanced-age-related-macular-degeneration
#7
REVIEW
Carlos A Moreira-Neto, Eric M Moult, James G Fujimoto, Nadia K Waheed, Daniela Ferrara
The purpose of this review is to summarize the current knowledge on choriocapillaris loss in advanced age macular degeneration (AMD). Several histopathological studies in animal models and human eyes had showed that the choriocapillaris density decreases with age. However, the role of choriocapillaris loss is still unclear in AMD and its advanced forms, either choroidal neovascularization (CNV) or geographic atrophy (GA). Some authors have hypothesized that choriocapillaris loss might precede overt retinal pigment epithelium atrophy...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29651166/energy-expenditure-for-massage-therapists-during-performing-selected-classical-massage-techniques
#8
Magdalena Więcek, Jadwiga Szymura, Marcin Maciejczyk, Zbigniew Szyguła, Jerzy Cempla, Mateusz Borkowski
OBJECTIVES: The aim of the study is to evaluate the intensity of the effort and energy expenditure in the course of performing selected classical massage techniques and to assess the workload of a massage therapist during a work shift. MATERIAL AND METHODS: Thirteen massage therapists (age: 21.9±1.9 years old, body mass index: 24.5±2.8 kg×m<sup>-2</sup>, maximal oxygen consumption × body mass<sup>-1</sup> (VO<sub>2 max</sub>×BM<sup>-1</sup>): 42...
April 11, 2018: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29650336/acute-physiological-responses-to-low-intensity-blood-flow-restriction-cycling
#9
H J Thomas, B R Scott, J J Peiffer
OBJECTIVES: Blood flow restriction (BFR) during interval cycling may stimulate aerobic and anaerobic adaptations. However, acute physiological responses to BFR interval cycling have not been extensively investigated. DESIGN: Eighteen males completed low-intensity (LI), low-intensity with BFR (LIBFR ) and high-intensity (HI) interval cycling sessions in randomised and counterbalanced order. These included a standardised warm-up and three two-min intervals interspersed with two-min recovery...
April 9, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29628895/rpe-vs-percentage-1rm-loading-in-periodized-programs-matched-for-sets-and-repetitions
#10
Eric R Helms, Ryan K Byrnes, Daniel M Cooke, Michael H Haischer, Joseph P Carzoli, Trevor K Johnson, Matthew R Cross, John B Cronin, Adam G Storey, Michael C Zourdos
Purpose: To investigate differences between rating of perceived exertion (RPE) and percentage one-repetition maximum (1RM) load assignment in resistance-trained males (19-35 years) performing protocols with matched sets and repetitions differentiated by load-assignment. Methods: Participants performed squats then bench press 3x/weeks in a daily undulating format over 8-weeks. Participants were counterbalanced by pre-test 1RM then assigned to percentage 1RM (1RMG, n = 11); load-assignment via percentage 1RMs, or RPE groups (RPEG, n = 10); participant-selected loads to reach target RPE ranges...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29627740/fatigability-and-functional-performance-among-older-adults-with-low-normal-ankle-brachial-index-cross-sectional-findings-from-the-baltimore-longitudinal-study-of-aging
#11
Pablo Martinez-Amezcua, Kunihiro Matsushita, Eleanor M Simonsick, Luigi Ferrucci, Jennifer A Schrack
BACKGROUND AND AIMS: Peripheral artery disease (PAD) is associated with poor mobility and fatigue, but the relationship between preclinical ankle-brachial index (ABI) and early markers of fatigue and functional decline has not been defined. METHODS: 570 adults, 50 and older, from the Baltimore Longitudinal Study of Aging (N = 570), with normal values of ABI (1-1.39), were classified into ABI tertiles. Perceived fatigability was assessed after a 5-min, treadmill walk (1...
March 22, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29627608/effect-of-wheelchair-stroke-pattern-on-upper-extremity-muscle-fatigue
#12
Brittany Bickelhaupt, Sakiko Oyama, Jonathan Benfield, Keith Burau, Shuko Lee, Michelle Trbovich
BACKGROUND: Shoulder dysfunction is common in persons with spinal cord injury (SCI) with an incidence of up to 63%1 . Dysfunction is a result of muscle imbalances, specifically denervated rotator cuff muscles that are repetitively used during manual wheelchair propulsion. OBJECTIVE: To determine which arm stroke technique, pump (P) or semicircular (SC), is most energy efficient for long periods of propulsion. DESIGN: A small randomized study with repeated-measures observations...
April 5, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29627466/a-polysaccharide-from-green-tea-camellia-sinensis-l-protects-human-retinal-endothelial-cells-against-hydrogen-peroxide-induced-oxidative-injury-and-apoptosis
#13
Yitao Yan, Yanfan Ren, Xinmin Li, Xinxia Zhang, Huiqing Guo, Yutong Han, Junxi Hu
Oxidative damage of retinal pigment epithelium (RPE) cells is involved in the pathogenesis age related macular degeneration (AMD). The purpose of this study was to evaluate the potential protective effect of a purified green tea polysaccharide (GTWP) against hydrogen peroxide (H2 O2 ) induced oxidative stress and apoptosis in human retinal pigment epithelial cells (ARPE-19 cells). Human ARPE-19 cells were treated with 1 h of 500 μM H2 O2 before incubation with GTWP for 24 h. Pretreatment of GTWP decreased H2 O2 -induced cell death and cell apoptosis, and efficiently suppressed the intracellular ROS production and malondialdehyde (MDA) generation induced by H2 O2 treatment...
April 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29626458/re-expansion-pulmonary-edema-after-asd-closure-through-right-sided-mini-thoracotomy
#14
Keiichi Hirose, Senri Miwa, Hisashi Sakaguchi, Shinya Takimoto, Yukiyo Yoshida, Yohei Onga, Yuichi Tara, Kazuo Yamanaka
We described a case suffering from re-expanded pulmonary edema (RPE) after atrial septal defect (ASD) closure through right-sided mini-thoracotomy. After re-expansion of the right lung after weaning from cardiopulmonary bypass (CPB), a large amount of serous slight-hemorrhagic bronchial secretions spilled out from the right bronchus. Positive pressure ventilation and differential ventilation were used. We found no bleeding and decreased secretions 24 hours after the onset of RPE. She was extubated 42 hours after the operation...
April 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29626055/internal-workload-and-non-contact-injury-a-one-season-study-of-five-teams-from-the-uefa-elite-club-injury-study
#15
Alan McCall, Gregory Dupont, Jan Ekstrand
BACKGROUND: Internal workload (ie, from training and matches) is considered one of the most important injury risk factors for elite European football teams, however there is little published evidence to support this belief. OBJECTIVE: We examined the association and predictive power of internal workload and non-contact injuries. METHODS: Five elite European teams, 171 players (age: 25.1±4.9 years; height: 181.6±6.7 cm; body mass: 77...
April 6, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29625486/structure-function-analysis-in-patients-with-intermediate-age-related-macular-degeneration
#16
Marlene Saßmannshausen, Julia S Steinberg, Rolf Fimmers, Maximilian Pfau, Sarah Thiele, Monika Fleckenstein, Frank G Holz, Steffen Schmitz-Valckenberg
Purpose: To examine the topographic correlation between retinal morphology and retinal sensitivity by mesopic and scotopic fundus-controlled perimetry (FCP) in eyes with intermediate AMD. Methods: Thirty-five eyes from 32 patients (mean age 70.9 years) and 29 age-matched controls prospectively underwent spectral-domain optical coherence tomography (SD-OCT) imaging. Mesopic (Goldman III, 200 ms, 4-2 strategy) and scotopic (Goldman V, 200 ms, 4-2 strategy) FCP with a 56-stimulus point grid was performed in AMD patients with the MP-1S...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625462/retinal-pigment-epithelial-cells-control-early-mycobacterium-tuberculosis-infection-via-interferon-signaling
#17
Rina La Distia Nora, Kimberley V Walburg, P Martin van Hagen, Sigrid M A Swagemakers, Peter J van der Spek, Edwin Quinten, Mirjam van Velthoven, Tom H M Ottenhoff, Willem A Dik, Mariëlle C Haks
Purpose: Mycobacterium tuberculosis (Mtb) bacilli have been found in retinal pigment epithelial (RPE) cells from uveitis patients without signs of systemic tuberculosis (TB) infection. RPE cells are important for ocular immune privilege and uveitis development. Methods: To address a potential role for Mtb-infected RPE cells in the development of uveitis, we delineated the response to Mtb infection in human RPE cells and primary human macrophages, the main target cell of Mtb...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625461/allogeneic-ipsc-derived-rpe-cell-graft-failure-following-transplantation-into-the-subretinal-space-in-nonhuman-primates
#18
Trevor J McGill, Jonathan Stoddard, Lauren M Renner, Ilhem Messaoudi, Kapil Bharti, Shoukhrat Mitalipov, Andreas Lauer, David J Wilson, Martha Neuringer
Purpose: To characterize the intraocular immune response following transplantation of iPS-derived allogeneic RPE cells into the subretinal space of non-immune-suppressed rhesus macaques. Methods: GFP-labeled allogeneic iPS-derived RPE cells were transplanted into the subretinal space of one eye (n = 6), and into the contralateral eye 1 day to 4 weeks later, using a two-stage transretinal and transscleral approach. Retinas were examined pre- and post-surgery by color fundus photography, fundus autofluorescence, and optical coherence tomography (OCT) imaging...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625455/release-of-different-cell-mediators-during-retinal-pigment-epithelium-regeneration-following-selective-retina-therapy
#19
Elisabeth Richert, Stefan Koinzer, Jan Tode, Kerstin Schlott, Ralf Brinkmann, Jost Hillenkamp, Alexa Klettner, Johann Roider
Purpose: To investigate the effect of selective retina therapy (SRT) on the release of AMD-relevant cell mediators, such as matrix metalloproteinases (MMPs), VEGF, and pigment epithelium derived factor (PEDF) using different laser spot sizes and densities. Methods: Porcine RPE-choroid explants were treated with a pulsed 532 nm Nd:YAG laser using (1) large spot sizes, (2) small spot sizes with a high-density (hd) treatment, and (3) small spot sizes with a low-density (ld) treatment...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29622681/heterochromatin-protects-retinal-pigment-epithelium-cells-from-oxidative-damage-by-silencing-p53-target-genes
#20
Lili Gong, Fangyuan Liu, Zhen Xiong, Ruili Qi, Zhongwen Luo, Xiaodong Gong, Qian Nie, Qian Sun, Yun-Fei Liu, Wenjie Qing, Ling Wang, Lan Zhang, Xiangcheng Tang, Shan Huang, Gen Li, Hong Ouyang, Mengqing Xiang, Quan Dong Nguyen, Yizhi Liu, David Wan-Cheng Li
Oxidative stress (OS)-induced retinal pigment epithelium (RPE) cell apoptosis is critically implicated in the pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness in the elderly. Heterochromatin, a compact and transcriptional inert chromatin structure, has been recently shown to be dynamically regulated in response to stress stimuli. The functional mechanism of heterochromatin on OS exposure is unclear, however. Here we show that OS increases heterochromatin formation both in vivo and in vitro, which is essential for protecting RPE cells from oxidative damage...
April 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
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