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https://www.readbyqxmd.com/read/28103505/hesperetin-protects-against-h2o2-triggered-oxidative-damage-via-upregulation-of-the-keap1-nrf2-ho-1-signal-pathway-in-arpe-19-cells
#1
Chao Zhu, Yuchen Dong, Haile Liu, Hua Ren, Zhihua Cui
Age-related macular degeneration (AMD) is an irreversible vision loss disease that primarily results from oxidative stress that causes oxidative damage to the retinal pigment epithelial (RPE) cells. Hesperetin (Hesp) is a common flavanone glycoside compound that has been demonstrated to exhibit a variety of biological and pharmacological properties that include anti-inflammatory and antioxidant properties. The aim of this study is to explore the ability of Hesp to attenuate oxidative damage in hydrogen peroxide (H2O2)-stimulated ARPE-19 cells...
January 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28102113/comparison-of-the-effects-on-dynamic-balance-and-aerobic-capacity-between-objective-and-subjective-methods-of-high-intensity-robot-assisted-gait-training-in-chronic-stroke-patients-a-randomized-controlled-trial
#2
Young-Hyeon Bae, Suck Min Lee, Mansoo Ko
BACKGROUND: Robot-assisted gait training (RAGT) is effective for improving dynamic balance and aerobic capacity, but previous RAGT method does not set suitable training intensity. Recently, high-intensity treadmill gait training at 70% of heart rate reserve (HRR) was used for improving aerobic capacity and dynamic balance. PURPOSE: This study was designed to compare the effectiveness between objective and subjective methods of high-intensity RAGT for improving dynamic balance and aerobic capacity in chronic stroke...
January 19, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28100662/zika-virus-causes-supernumerary-foci-with-centriolar-proteins-and-impaired-spindle-positioning
#3
Benita Wolf, Fodé Diop, Pauline Ferraris, Sineewanlaya Wichit, Coralie Busso, Dorothée Missé, Pierre Gönczy
Zika virus (ZIKV) causes congenital microcephaly. Although ZIKV can impair cell cycle progression and provoke apoptosis, which probably contributes to disease aetiology through depletion of neural progenitor cells, additional cellular mechanisms may be important. Here, we investigated whether ZIKV infection alters centrosome number and spindle positioning, because such defects are thought to be at the root of inherited primary autosomal recessive microcephaly (MCPH). In addition to HeLa cells, in which centrosome number and spindle positioning can be well monitored, we analysed retinal epithelial cells (RPE-1), as well as brain-derived microglial (CHME-5) and neural progenitor (ReN) cells, using immunofluorescence...
January 2017: Open Biology
https://www.readbyqxmd.com/read/28099966/involvement-of-xbp1s-in-blue-light-induced-a2e-containing-retinal-pigment-epithelium-cell-death
#4
Bing Lu, Pengfei Zhang, Minwen Zhou, Wenqiu Wang, Qing Gu, Jingyang Feng, Xueting Luo, Xiangjun Sun, Fenghua Wang, Xiaodong Sun
PURPOSE: Retinal pigment epithelium (RPE) cell dysfunction is essential to the development of retinal degenerative disease. This study was designed to investigate how spliced X-box-binding protein 1 (XBP1s) regulates different modes of RPE cell death in vitro. METHODS: Human ARPE19 cells were incubated with 25 μM N-retinylidene-N-retinylethanolamine (A2E) and irradiated with blue light. Expressions of glucose-regulated protein 78 (GRP78) and XBP1s were detected by real-time quantitative PCR and Western blot...
January 19, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28099337/phototoxic-maculopathy-induced-by-quartz-infrared-heat-lamp-a-clinical-case-report
#5
Xinhua Zheng, Ping Xie, Zizhong Hu, Weiwei Zhang, Kang Liang, Xiuying Wang, Qinghuai Liu
RATIONALE: A large proportion of the output of quartz infrared heat lamps is emitted as infrared radiation (IR). Retinal damage induced by IR-A and visible light on arc welders has been reported. However, case reports of retinal damage caused by quartz infrared heat lamps are rare. To the best of our knowledge, this is the first reported case of phototoxic maculopathy induced by quartz infrared heat lamps. PATIENT CONCERNS: We report a female with a 1-month history of progressive blurred vision and dysmorphopsia in her right eye after improper staring at the tubes of a quartz infrared heater...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28098730/novel-classification-system-for-combined-hamartoma-of-the-retina-and-retinal-pigment-epithelium
#6
Vaidehi S Dedania, Cem Ozgonul, David N Zacks, Cagri G Besirli
PURPOSE: To develop an anatomical classification scheme for combined hamartoma of the retina and retinal pigment epithelium (RPE) and specify recommendations for follow-up interval. METHODS: Retrospective review of patients with combined hamartoma of the retina and RPE examined during a 7-year period (2008-2015). The clinical presentation, fundus examination, and optical coherence tomography were analyzed. RESULTS: Lesions were classified based on location, fundus features, and optical coherence tomography findings...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098621/long-term-follow-up-of-retinal-pigment-epithelium-restoration-after-a-triple-tear
#7
Sarwar Zahid, Rosa Dolz Marco, K Bailey Freund
PURPOSE: To demonstrate longitudinal multimodal imaging findings in a case of neovascular age-related macular degeneration presenting with multiple retinal pigment epithelium (RPE) tears showing progressive RPE restoration. METHODS: Observational clinical case report. RESULTS: A 79-year-old woman diagnosed with neovascular age-related macular degeneration developed 3 consecutive RPE tears in her right eye during the course of treatment with intravitreal anti-vascular endothelial growth factor therapy...
December 19, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28095077/running-performance-with-nutritive-and-non-nutritive-sweetened-mouth-rinses
#8
Keely H Hawkins, Sridevi Krishnan, Lara Ringos, Vanessa Garcia, Jamie A Cooper
: Mouth rinsing (MR) with carbohydrate during exercise has been shown to act as an ergogenic aid. PURPOSE: To investigate if nutritive or nonnutritive sweetened MR affect exercise performance, and to assess the influence of sweetness intensity on endurance performance during a time-trial (TT). METHODS: This randomized, single blinded study had 4 treatment conditions. 16 subjects (9 men, 7 women) completed a 12.8km TT four different times. During each TT, subjects MR and expectorated a different solution at time 0 and every 12...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28095076/impaired-player-coach-perceptions-of-exertion-and-recovery-during-match-congestion
#9
Steven H Doeven, Michel S Brink, Wouter G P Frencken, Koen A P M Lemmink
: During intensified phases of competition, attunement of exertion and recovery is crucial to maintain performance. Although a mismatch between coach' and players' perceptions of training load is demonstrated, it is unknown if these discrepancies also exist for match exertion and recovery. PURPOSE: The aims of this study are to determine match exertion, subsequent recovery and to investigate to what extent the coach is able to estimate players' match exertion and recovery...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28095070/player-responses-to-match-and-training-demands-during-an-intensified-fixture-schedule-in-professional-rugby-league-a-case-study
#10
Craig Twist, Jamie Highton, Matthew Daniels, Nathan Mill, Graeme Close
Player loads and fatigue responses were reported in 15 professional rugby league players (24.3 ± 3.8 y) during a period of intensified fixtures. Repeated measures of internal and external loads, perceived wellbeing and jump flight time were recorded across 22 days, comprising nine training sessions and matches on days 5, 12, 15 and 21 (player exposure: 3.6 ± 0.6 matches). Mean training load (session RPE x duration) between matches was 1177, 1083, 103, and 650 AU, respectively. Relative distance in Match 1 (82 m/min) and Match 4 (79 m/min) was very likely lower in Match 2 (76 m/min) and likely higher in Match 3 (86 m/min)...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28095061/methods-of-monitoring-training-load-and-their-relationships-to-changes-in-fitness-and-performance-in-competitive-road-cyclists
#11
Dajo Sanders, Grant Abt, Matthijs K Hesselink, Tony Myers, Ibrahim Akubat
PURPOSE: The aim of this study was to assess the dose-response relationships between different training load methods and aerobic fitness and performance in competitive road cyclists. METHOD: Training data from 15 well-trained competitive cyclists were collected during a 10-week (December - March) pre-season training period. Before and after the training period, participants underwent a laboratory incremental exercise test with gas exchange and lactate measures and a performance assessment using an 8-min time trial (8MT)...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28094489/the-sex-specific-internal-and-external-demands-imposed-on-players-during-ultimate-frisbee-game-play
#12
Maria C Madueno, Crystal O Kean, Aaron T Scanlan
BACKGROUND: Despite the growing popularity of Ultimate Frisbee (UF) across sexes, the game demands imposed on players have been predominately examined in males. This study aimed to compare the internal and external demands of UF game-play in males and females. METHODS: Male (N = 10) and female (N = 10) recreational UF players competed in separate sex-specific, indoor UF games. Internal responses (blood lactate concentration ([BLa-]), rating of perceived exertion (RPE), and heart rate (HR)) and external responses (direction-specific and total relative (·min-1) PlayerLoadTM (PL), and Estimated Equivalent Distance (EED)) were measured...
January 17, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28092315/choroidal-blood-vessels-in-retinal-pigment-epithelial-atrophy-using-optical-coherence-tomography-angiography
#13
Ichiro Maruko, Hideki Koizumi, Shota Sawaguchi, Taiji Hasegawa, Hisaya Arakawa, Tomohiro Iida
PURPOSE: To observe choroidal blood vessels in cases sharply demarcated with retinal pigment epithelium (RPE) atrophy at the macular area using en-face optical coherence tomography angiography (OCTA) and standard en-face optical coherence tomography (OCT). METHODS: The retrospective study included 12 eyes (8 patients; 5 men, 3 women; average age, 64.3 years) with RPE atrophy seen by ophthalmoscopy. The macular areas with normal and atrophic RPE sections were examined using en-face OCTA with an 840-nm light source (RTVue XR Avanti; Optovue Inc), which system can obtain standard en-face OCT images at identical areas...
January 13, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28092208/the-effects-of-mental-fatigue-on-cricket-relevant-performance-among-elite-players
#14
Daren Veness, Stephen David Patterson, Owen Jeffries, Mark Waldron
This study investigated the effects of a mentally fatiguing test on physical tasks among elite cricketers. In a cross-over design, 10 elite male cricket players from a professional club performed a cricket run-two test, a Batak Lite reaction time test and a Yo-Yo-Intermittent Recovery Level 1 (Yo-Yo-IR1) test, providing a rating of perceived exertion (RPE) after completing a 30-min Stroop test (mental fatigue condition) or 30-min control condition. Perceived fatigue was assessed before and after the two conditions and motivation was measured before testing...
January 16, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28091446/correlation-between-athlete-training-intensity-and-cardiac-performance
#15
T Xiao, Y Zhang
OBJECTIVE: An effective analysis of correlation between training intensity of athletes and cardiac performance is done to develop scientific and reasonable exercise program and to promote health of athletes. METHODS: During December 2013-December 2015, 3600 students from different sports schools were selected for the test. All the athletes were randomly grouped, that is half-hour running group, one-hour running group and 90 -minute running group, which are named A, B, C groups respectively...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28090140/influence-of-warm-up-duration-and-recovery-interval-prior-to-exercise-on-anaerobic-performance
#16
M Frikha, N Chaâri, N Mezghanni, N Souissi
The purpose of the study was to determine the impact of different active warm-up (AWU) durations and the rest interval separating it from exercise on anaerobic performance. Eleven male physical education students (22.6 ± 2.52 years; 179.2 ± 4.3 cm; 82.5 ± 9.7 kg; mean ± SD) participated in a cross-over randomized study, and they all underwent the Wingate test after three AWU durations: 5 min (AWU5), 15 min (AWU15) and 20 min (AWU20), with recovery (WREC) or without a recovery interval (NREC) separating the AWU and anaerobic exercise performance...
December 2016: Biology of Sport
https://www.readbyqxmd.com/read/28088625/absence-of-dj-1-causes-age-related-retinal-abnormalities-in-association-with-increased-oxidative-stress
#17
Vera L Bonilha, Brent A Bell, Mary E Rayborn, Ivy S Samuels, Anna King, Joe G Hollyfield, Chengsong Xie, Huaibin Cai
Oxidative stress alters physiological function in most biological tissues and can lead to cell death. In the retina, oxidative stress initiates a cascade of events leading to focal loss of RPE and photoreceptors, which is thought to be a major contributing factor to geographic atrophy. Despite these implications, the molecular regulation of RPE oxidative stress under normal and pathological conditions remains largely unknown. A better understanding of the mechanisms involved in regulating RPE and photoreceptors oxidative stress response is greatly needed...
January 11, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28088558/the-effects-of-upper-body-exercise-across-different-levels-of-blood-flow-restriction-on-arterial-occlusion-pressure-and-perceptual-responses
#18
Kevin T Mattocks, Matthew B Jessee, Brittany R Counts, Samuel L Buckner, J Grant Mouser, Scott J Dankel, Gilberto C Laurentino, Jeremy P Loenneke
Recent studies have investigated relative pressures that are applied during blood flow restriction exercise ranging from 40%-90% of resting arterial occlusion pressure; however, no studies have investigated relative pressures below 40% arterial occlusion pressure. The purpose of this study was to characterize the cardiovascular and perceptual responses to different levels of pressures. Twenty-six resistance trained participants performed four sets of unilateral elbow flexion exercise using 30% of their 1RM in combination with blood flow restriction inflated to one of six relative applied pressures (0%, 10%, 20%, 30%, 50%, 90% arterial occlusion pressure)...
January 11, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28079704/modeling-perceived-exertion-during-graded-arm-cycling-exercise-in-spinal-cord-injury
#19
Jason S Au, Julia O Totosy de Zepetnek, Maureen J MacDonald
PURPOSE: Ratings of perceived exertion (RPE) may be useful for exercise testing and prescription in individuals with spinal cord injury (SCI), though the roles of differentiated central and peripheral fatigue during exercise are not clear. We aimed to model differentiated RPE responses during graded arm cycling in individuals with SCI and describe their relationship to cardiorespiratory outcomes. METHODS: Thirty-six individuals with SCI (13 paraplegia; 23 tetraplegia) completed a maximal graded-arm cycling exercise test to volitional exhaustion (5W/min paraplegia; 10W/min tetraplegia)...
January 10, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28077716/the-attraction-effect-modulates-reward-prediction-errors-and-intertemporal-choices
#20
Sebastian Gluth, Jared M Hotaling, Jörg Rieskamp
: Classical economic theory contends that the utility of a choice option should be independent of other options. This view is challenged by the attraction effect, in which the relative preference between two options is altered by the addition of a third, asymmetrically dominated option. Here, we leveraged the attraction effect in the context of intertemporal choices to test whether both decisions and reward prediction errors (RPE) in the absence of choice violate the independence of irrelevant alternatives principle...
January 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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