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resveratrol and microbiota

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https://www.readbyqxmd.com/read/27792146/piceatannol-exerts-anti-obesity-effects-in-c57bl-6-mice-through-modulating-adipogenic-proteins-and-gut-microbiota
#1
Yen-Chen Tung, Yu-Hsuan Lin, Hong-Jhang Chen, Shen-Chieh Chou, An-Chin Cheng, Nagabhushanam Kalyanam, Chi-Tang Ho, Min-Hsiung Pan
Obesity is a global health concern. Piceatannol (Pic), an analog of resveratrol (Res), has many reported biological activities. In this study, we investigated the anti-obesity effect of Pic in a high-fat diet (HFD)-induced obese animal model. The results showed that Pic significantly reduced mouse body weight in a dose-dependent manner without affecting food intake. Serum total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) levels, and blood glucose (GLU) were significantly lowered in Pic-treated groups...
October 25, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27713962/dietary-supplement-based-on-stilbenes-a-focus-on-gut-microbial-metabolism-by-the-in-vitro-simulator-m-shime%C3%A2
#2
Camilla Giuliani, Massimo Marzorati, Marzia Innocenti, Ramiro Vilchez-Vargas, Marius Vital, Dietmar H Pieper, Tom Van de Wiele, Nadia Mulinacci
Polyphenols and intestinal microbiota can influence each other, modifying metabolism and gut wellness. Data on this mutual effect need to be improved. Several studies on the biological activities of resveratrol and derivatives have been carried out, but the effects of a continuous administration of stilbenes on gut microbiota have not yet been investigated. This study evaluated the effects of an extract from Vitis vinifera, containing a combination of t-resveratrol and ε-viniferin, on intestinal microbiota, using the advanced gastrointestinal simulator M-SHIME®...
October 7, 2016: Food & Function
https://www.readbyqxmd.com/read/27471110/chronic-repression-of-mtor-complex-2-induces-changes-in-the-gut-microbiota-of-diet-induced-obese-mice
#3
Mi-Ja Jung, Jina Lee, Na-Ri Shin, Min-Soo Kim, Dong-Wook Hyun, Ji-Hyun Yun, Pil Soo Kim, Tae Woong Whon, Jin-Woo Bae
Alterations in the gut microbiota play a crucial role in host physiology and metabolism; however, the molecular pathways underlying these changes in diet-induced obesity are unclear. Mechanistic target of rapamycin (mTOR) signaling pathway is associated with metabolic disorders such as obesity and type 2 diabetes (T2D). Therefore, we examined whether changes in the regulation of mTOR signaling induced by diet (a high-fat diet [HFD] or normal-chow diet) and/or therapeutics (resveratrol [a specific inhibitor of mTOR complex 1] or rapamycin [an inhibitor of both mTOR complex 1 and 2]) altered the composition of the gut microbiota in mice...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27438462/silac-ms-based-characterization-of-lps-and-resveratrol-induced-changes-in-adipocyte-proteomics-resveratrol-as-ameliorating-factor-on-lps-induced-changes
#4
Mark K Nøhr, Toke P Kroager, Kristian W Sanggaard, Anders D Knudsen, Allan Stensballe, Jan J Enghild, Jens Ølholm, Bjørn Richelsen, Steen B Pedersen
Adipose tissue inflammation is believed to play a pivotal role in the development obesity-related morbidities such as insulin resistance. However, it is not known how this (low-grade) inflammatory state develops. It has been proposed that the leakage of lipopolysaccharides (LPS), originating from the gut microbiota, through the gut epithelium could drive initiation of inflammation. To get a better understanding of which proteins and intracellular pathways are affected by LPS in adipocytes, we performed SILAC proteomic analysis and identified proteins that were altered in expression...
2016: PloS One
https://www.readbyqxmd.com/read/27274718/the-chemistry-of-gut-microbial-metabolism-of-polyphenols
#5
Jan F Stevens, Claudia S Maier
Gut microbiota contribute to the metabolism of dietary polyphenols and affect the bioavailability of both the parent polyphenols and their metabolites. Although there is a large number of reports of specific polyphenol metabolites, relatively little is known regarding the chemistry and enzymology of the metabolic pathways utilized by specific microbial species and taxa, which is the focus of this review. Major classes of dietary polyphenols include monomeric and oligomeric catechins (proanthocyanidins), flavonols, flavanones, ellagitannins, and isoflavones...
June 2016: Phytochemistry Reviews: Proceedings of the Phytochemical Society of Europe
https://www.readbyqxmd.com/read/27048804/resveratrol-attenuates-trimethylamine-n-oxide-tmao-induced-atherosclerosis-by-regulating-tmao-synthesis-and-bile-acid-metabolism-via-remodeling-of-the-gut-microbiota
#6
Ming-liang Chen, Long Yi, Yong Zhang, Xi Zhou, Li Ran, Jining Yang, Jun-dong Zhu, Qian-yong Zhang, Man-tian Mi
UNLABELLED: The gut microbiota is found to be strongly associated with atherosclerosis (AS). Resveratrol (RSV) is a natural phytoalexin with anti-AS effects; however, its mechanisms of action remain unclear. Therefore, we sought to determine whether the anti-AS effects of RSV were related to changes in the gut microbiota. We found that RSV attenuated trimethylamine-N-oxide (TMAO)-induced AS in ApoE(-/-) mice. Meanwhile, RSV decreased TMAO levels by inhibiting commensal microbial trimethylamine (TMA) production via gut microbiota remodeling in mice...
2016: MBio
https://www.readbyqxmd.com/read/26792656/limited-beneficial-effects-of-piceatannol-supplementation-on-obesity-complications-in-the-obese-zucker-rat-gut-microbiota-metabolic-endocrine-and-cardiac-aspects
#7
E Hijona, L Aguirre, P Pérez-Matute, M J Villanueva-Millán, A Mosqueda-Solis, M Hasnaoui, F Nepveu, J M Senard, L Bujanda, L Aldámiz-Echevarría, M Llarena, F Andrade, P Perio, F Leboulanger, L Hijona, J M Arbones-Mainar, M P Portillo, C Carpéné
Resveratrol is beneficial in obese and diabetic rodents. However, its low bioavailability raises questions about its therapeutic relevance for treating or preventing obesity complications. In this context, many related natural polyphenols are being tested for their putative antidiabetic and anti-obesity effects. This prompted us to study the influence of piceatannol, a polyhydroxylated stilbene, on the prevention of obesity complications in Zucker obese rats. A 6-week supplementation was followed by the determination of various markers in plasma, liver, adipose tissue and heart, together with a large-scale analysis of gut microbiota composition...
September 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/26706021/beneficial-action-of-resveratrol-how-and-why
#8
REVIEW
Gustavo Tomas Diaz-Gerevini, Gaston Repossi, Alejandro Dain, María Cristina Tarres, Undurti Narasimha Das, Aldo Renato Eynard
Flavonoid resveratrol modulates the transcription factor NF-κB; inhibits the cytochrome P450 isoenzyme CYP1 A1; suppresses the expression and activity of cyclooxygenase enzymes; and modulates Fas/Fas-ligand-mediated apoptosis, p53, mammalian target of rapamycin, and cyclins and various phosphodiesterases. This increases the cytosolic cAMP that activates Epac1/CaMKKβ/AMPK/SIRT1/PGC-1α pathway, which in turn facilitates increased oxidation of fatty acids, mitochondrial biogenesis, mitochondrial respiration, and gluconeogenesis...
February 2016: Nutrition
https://www.readbyqxmd.com/read/26156396/metabolic-faecal-fingerprinting-of-trans-resveratrol-and-quercetin-following-a-high-fat-sucrose-dietary-model-using-liquid-chromatography-coupled-to-high-resolution-mass-spectrometry
#9
Usune Etxeberria, Noemi Arias, Noemí Boqué, Ana Romo-Hualde, M Teresa Macarulla, María P Portillo, Fermín I Milagro, J Alfredo Martínez
Faecal non-targeted metabolomics deciphers metabolic end-products resulting from the interactions among food, host genetics, and gut microbiota. Faeces from Wistar rats fed a high-fat sucrose (HFS) diet supplemented with trans-resveratrol and quercetin (separately or combined) were analysed by liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS). Metabolomics in faeces are categorised into four clusters based on the type of treatment. Tentative identification of significantly differing metabolites highlighted the presence of carbohydrate derivatives or conjugates (3-phenylpropyl glucosinolate and dTDP-D-mycaminose) in the quercetin group...
August 2015: Food & Function
https://www.readbyqxmd.com/read/25762527/reshaping-faecal-gut-microbiota-composition-by-the-intake-of-trans-resveratrol-and-quercetin-in-high-fat-sucrose-diet-fed-rats
#10
U Etxeberria, N Arias, N Boqué, M T Macarulla, M P Portillo, J A Martínez, F I Milagro
Diet-induced obesity is associated to an imbalance in the normal gut microbiota composition. Resveratrol and quercetin, widely known for their health beneficial properties, have low bioavailability, and when they reach the colon, they are targets of the gut microbial ecosystem. Hence, the use of these molecules in obesity might be considered as a potential strategy to modulate intestinal bacterial composition. The purpose of this study was to determine whether trans-resveratrol and quercetin administration could counteract gut microbiota dysbiosis produced by high-fat sucrose diet (HFS) and, in turn, improve gut health...
June 2015: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/24722352/effects-of-resveratrol-on-gut-microbiota-and-fat-storage-in-a-mouse-model-with-high-fat-induced-obesity
#11
Yi Qiao, Jin Sun, Shufang Xia, Xue Tang, Yonghui Shi, Guowei Le
Recent studies have investigated the anti-obesity effect of resveratrol, but the pathways through which resveratrol resists obesity are not clear. In the present study, we hypothesize that resveratrol exerts anti-obesity effects that are likely mediated by mechanisms of regulating gut microbes, and in turn, improving fat storage and metabolism. Gut microbes, glucose and lipid metabolism in high-fat diet (HF) mice in vivo are investigated after resveratrol treatment. Several biochemical markers are measured...
June 2014: Food & Function
https://www.readbyqxmd.com/read/24534456/new-and-emerging-regulators-of-intestinal-lipoprotein-secretion
#12
REVIEW
Changting Xiao, Satya Dash, Cecilia Morgantini, Gary F Lewis
Overproduction of hepatic apoB100-containing VLDL particles has been well documented in animal models and in humans with insulin resistance such as the metabolic syndrome and type 2 diabetes, and contributes to the typical dyslipidemia of these conditions. In addition, postprandial hyperlipidemia and elevated plasma concentrations of intestinal apoB48-containing chylomicron and chylomicron remnant particles have been demonstrated in insulin resistant states. Intestinal lipoprotein production is primarily determined by the amount of fat ingested and absorbed...
April 2014: Atherosclerosis
https://www.readbyqxmd.com/read/23283496/in-vivo-and-in-vitro-metabolism-of-trans-resveratrol-by-human-gut-microbiota
#13
Lisa M Bode, Diana Bunzel, Melanie Huch, Gyu-Sung Cho, Denise Ruhland, Mirko Bunzel, Achim Bub, Charles M A P Franz, Sabine E Kulling
BACKGROUND: Strong interindividual differences in the microbial conversion of some dietary polyphenols have been reported. In-depth studies of trans-resveratrol metabolism by human gut microbiota, however, are lacking, and only one bacterial metabolite, namely dihydroresveratrol, has been described. OBJECTIVE: The aim of this study was to elucidate interindividual differences in trans-resveratrol metabolism by human gut microbiota and to identify bacterial strains involved...
February 2013: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/22989504/gut-microbiota-immune-development-and-function
#14
REVIEW
Stig Bengmark
The microbiota of Westerners is significantly reduced in comparison to rural individuals living a similar lifestyle to our Paleolithic forefathers but also to that of other free-living primates such as the chimpanzee. The great majority of ingredients in the industrially produced foods consumed in the West are absorbed in the upper part of small intestine and thus of limited benefit to the microbiota. Lack of proper nutrition for microbiota is a major factor under-pinning dysfunctional microbiota, dysbiosis, chronically elevated inflammation, and the production and leakage of endotoxins through the various tissue barriers...
March 2013: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/22906730/pharmacokinetics-of-resveratrol-metabolic-profile-in-healthy-humans-after-moderate-consumption-of-red-wine-and-grape-extract-tablets
#15
RANDOMIZED CONTROLLED TRIAL
Maria Rotches-Ribalta, Cristina Andres-Lacueva, Ramon Estruch, Elvira Escribano, Mireia Urpi-Sarda
A pharmacokinetic study of the metabolic profile of resveratrol has been performed in healthy men after moderate red wine (RW) consumption. The bioavailability of resveratrol is highly influenced by several factors such as the food matrix and, therefore, this study has been compared with a pilot study in which men ingested grape extract (GE) tablets as a nutraceutical, containing similar total amounts of resveratrol than RW. Blood and urine samples were taken before and at several time points after intervention and then analyzed by SPE and LC-ESI-MS/MS...
November 2012: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/22533982/distribution-of-resveratrol-metabolites-in-liver-adipose-tissue-and-skeletal-muscle-in-rats-fed-different-doses-of-this-polyphenol
#16
Cristina Andres-Lacueva, M Teresa Macarulla, Maria Rotches-Ribalta, María Boto-Ordóñez, Mireia Urpi-Sarda, Víctor M Rodríguez, María P Portillo
This study aimed to characterize resveratrol metabolite profiles in liver, skeletal muscle, and adipose tissue in rats treated for 6 weeks with 6, 30, or 60 mg of trans-resveratrol/kg body weight/d. Resveratrol metabolites were quantified by liquid chromatography-tandem mass spectrometry. The greatest number of metabolites was found in liver followed by adipose tissue. A great number of metabolites in muscle was below the limit of detection. The amounts of sulfate conjugates tended to increase when resveratrol dosage was enhanced, while the glucuronide ones increased only between 6 and 30 mg/kg/d...
May 16, 2012: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/21673955/resveratrol-increases-glucose-induced-glp-1-secretion-in-mice-a-mechanism-which-contributes-to-the-glycemic-control
#17
Thi-Mai Anh Dao, Aurélie Waget, Pascale Klopp, Matteo Serino, Christelle Vachoux, Laurent Pechere, Daniel J Drucker, Serge Champion, Sylvain Barthélemy, Yves Barra, Rémy Burcelin, Eric Sérée
Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targets primarily responsible for the beneficial actions of RSV remain unclear. We used a formulation that increases oral bioavailability to assess the mechanisms involved in the glucoregulatory action of RSV in high-fat diet (HFD)-fed diabetic wild type mice. Administration of RSV for 5 weeks reduced the development of glucose intolerance, and increased portal vein concentrations of both Glucagon-like peptid-1 (GLP-1) and insulin, and intestinal content of active GLP-1...
2011: PloS One
https://www.readbyqxmd.com/read/21130054/investigation-of-piceid-metabolites-in-rat-by-liquid-chromatography-tandem-mass-spectrometry
#18
Donggeng Wang, Zhiwen Zhang, Jianfeng Ju, Xinyang Wang, Wenjing Qiu
There is considerable evidence that stilbenes provide health benefits. Trans-piceid is one of the major stilbenoid compounds in red wine and other plants. The purpose of this study is to investigate the metabolism of piceid in rats, including its conversion product by intestinal microflora in vitro and urinary metabolites. A HPLC-MS/MS method with electrospray ionization (ESI), negative ion mode and collision induced dissociation (CID), was used to elucidate the structures of the major metabolites of piceid...
January 1, 2011: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/19228061/effect-of-a-low-dose-of-dietary-resveratrol-on-colon-microbiota-inflammation-and-tissue-damage-in-a-dss-induced-colitis-rat-model
#19
Mar Larrosa, María Josefa Yañéz-Gascón, María Victoria Selma, Antonio González-Sarrías, Simona Toti, José Joaquín Cerón, Francisco Tomás-Barberán, Piero Dolara, Juan Carlos Espín
The naturally occurring polyphenol resveratrol has been acknowledged with health-beneficial properties. Most of the studies dealing with its in vivo effects assay huge doses, not representative from a dietary point of view. Our aim was to ascertain whether resveratrol can exert anti-inflammatory activity in vivo at an attainable dietary dose. Rats were fed with 1 mg of resveratrol/kg/day (a human equivalent dose) for 25 days, and in the last 5 days, 5% dextran sulfate sodium (DSS) was administered to induce colitis...
March 25, 2009: Journal of Agricultural and Food Chemistry
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