keyword
MENU ▼
Read by QxMD icon Read
search

Siv

keyword
https://www.readbyqxmd.com/read/28819214/hiv-1-nef-induced-cardiotoxicity-through-dysregulation-of-autophagy
#1
Manish K Gupta, Rafal Kaminski, Brian Mullen, Jennifer Gordon, Tricia H Burdo, Joseph Y Cheung, Arthur M Feldman, Muniswamy Madesh, Kamel Khalili
Cardiovascular disease is a leading cause of co-morbidity in HIV-1 positive patients, even those in whom plasma virus levels are well-controlled. The pathogenic mechanism of HIV-1-associated cardiomyopathy is unknown, but has been presumed to be mediated indirectly, owing to the absence of productive HIV-1 replication in cardiomyocytes. We sought to investigate the effect of the HIV-1 auxiliary protein, Nef, which is suspected of extracellular release by infected CD4+ T cells on protein quality control and autophagy in cardiomyocytes...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28817110/extractive-spectrophotometric-determination-of-nortriptyline-hydrochloride-using-sudan-ii-iv-and-black-b
#2
A S Amin, H M Saleh
A simple spectrophotometric methods has been developed for the determination of nortriptyline hydrochloride in pure and in pharmaceuticalformulations based on the formation of ion-pair complexes with sudun II (SII), sudan (IV) (SIV) and sudan black B (SBB). The selectivity of the method was improved through extraction with chloroform. The optimum conditions for complete extracted colour development were assessed. The absorbance measurements were made at 534, 596 and 649 nm for SII, SIV and SBB complexes, respectively...
August 17, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28814779/the-beach-protein-lrba-promotes-the-localization-of-the-heterotrimeric-g-protein-golf-to-olfactory-cilia
#3
Stefan Kurtenbach, Andreas Gießl, Siv Strömberg, Jan Kremers, Jenny Atorf, Sebastian Rasche, Eva M Neuhaus, Denis Hervé, Johann Helmut Brandstätter, Esther Asan, Hanns Hatt, Manfred W Kilimann
BEACH domain proteins are involved in membrane protein traffic and human diseases, but their molecular mechanisms are not understood. The BEACH protein LRBA has been implicated in immune response and cell proliferation, and human LRBA mutations cause severe immune deficiency. Here, we report a first functional and molecular phenotype outside the immune system of LRBA-knockout mice: compromised olfaction, manifesting in reduced electro-olfactogram response amplitude, impaired food-finding efficiency, and smaller olfactory bulbs...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28812079/computational-evaluation-of-aluminophosphate-zeotypes-for-co2-n2-separation
#4
Michael Fischer
Zeolites and structurally related materials (zeotypes) have received considerable attention as potential adsorbents for selective carbon dioxide adsorption. Within this group, zeotypes with aluminophosphate composition (AlPOs) could be an interesting alternative to the more frequently studied aluminosilicate zeolites. So far, however, only a few AlPOs have been characterised experimentally in terms of their CO2 adsorption properties. In this study, force-field based grand-canonical Monte Carlo (GCMC) simulations were used to evaluate the potential of AlPOs for CO2/N2 separation, a binary mixture that constitutes a suitable model system for the removal of carbon dioxide from flue gases...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28811349/brain-macrophages-in-simian-immunodeficiency-virus-infected-antiretroviral-suppressed-macaques-a-functional-latent-reservoir
#5
Claudia R Avalos, Celina M Abreu, Suzanne E Queen, Ming Li, Sarah Price, Erin N Shirk, Elizabeth L Engle, Ellen Forsyth, Brandon T Bullock, Feilim Mac Gabhann, Stephen W Wietgrefe, Ashley T Haase, M Christine Zink, Joseph L Mankowski, Janice E Clements, Lucio Gama
A human immunodeficiency virus (HIV) infection cure requires an understanding of the cellular and anatomical sites harboring virus that contribute to viral rebound upon treatment interruption. Despite antiretroviral therapy (ART), HIV-associated neurocognitive disorders (HAND) are reported in HIV-infected individuals on ART. Biomarkers for macrophage activation and neuronal damage in cerebrospinal fluid (CSF) of HIV-infected individuals demonstrate continued effects of HIV in brain and suggest that the central nervous system (CNS) may serve as a viral reservoir...
August 15, 2017: MBio
https://www.readbyqxmd.com/read/28809434/pneumatosis-intestinalis-in-an-siv-infected-rhesus-macaque-macaca-mulatta
#6
A L Johnson, K Van Rompay, J R Reader
Pneumatosis intestinalis (PI) has been described as an incidental finding in domestic animals and humans where it is associated with human immunodeficiency virus infection among other comorbidities. This report describes emphysematous changes consistent with PI in a simian immunodeficiency virus (SIV)-infected rhesus macaque (Macaca mulatta).
August 15, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28803141/the-poly-proline-tail-of-sivmac-vpx-provides-gain-of-function-for-resistance-to-a-cryptic-proteasome-dependent-degradation-pathway
#7
Nannan Zhang, Haoran Guo, Jiaxin Yang, Guanchen Liu, Shuang Li, Siying Li, Dongyin Wang, Rui Li, Chang Shu, Hongmei Xu, Zhentong Wei, Honglan Huang, Songling Zhang, Pujun Gao, Shan Cen, Richard Markham, Yongsheng Wang, Xiao-Fang Yu, Wei Wei
The lentiviral accessory protein Vpx is critical for viral infection of myeloid cells and acts by hijacking CRL4(DCAF1) E3 ubiquitin ligase to induce the degradation of the host restriction factor SAMHD1. It has been observed that the sequences from HIV-2 and SIVsmm/SIVmac Vpx contain a poly-proline tail which is distinct from other SIV Vpx proteins. However, the role of this region in Vpx function is controversial. Herein, we found proteasome-dependent degradation of a Vpx mutant lacking the poly-proline tail in the nucleus in a CRL4(DCAF1) E3 ligase-independent fashion...
August 10, 2017: Virology
https://www.readbyqxmd.com/read/28795682/effects-of-antenatal-diet-and-physical-activity-on-maternal-and-fetal-outcomes-individual-patient-data-meta-analysis-and-health-economic-evaluation
#8
Ewelina Rogozińska, Nadine Marlin, Louise Jackson, Girish Rayanagoudar, Anneloes E Ruifrok, Julie Dodds, Emma Molyneaux, Mireille Nm van Poppel, Lucilla Poston, Christina A Vinter, Fionnuala McAuliffe, Jodie M Dodd, Julie Owens, Ruben Barakat, Maria Perales, Jose G Cecatti, Fernanda Surita, SeonAe Yeo, Annick Bogaerts, Roland Devlieger, Helena Teede, Cheryce Harrison, Lene Haakstad, Garry X Shen, Alexis Shub, Nermeen El Beltagy, Narges Motahari, Janette Khoury, Serena Tonstad, Riitta Luoto, Tarja I Kinnunen, Kym Guelfi, Fabio Facchinetti, Elisabetta Petrella, Suzanne Phelan, Tânia T Scudeller, Kathrin Rauh, Hans Hauner, Kristina Renault, Christianne Jm de Groot, Linda R Sagedal, Ingvild Vistad, Signe Nilssen Stafne, Siv Mørkved, Kjell Å Salvesen, Dorte M Jensen, Márcia Vitolo, Arne Astrup, Nina Rw Geiker, Sally Kerry, Pelham Barton, Tracy Roberts, Richard D Riley, Arri Coomarasamy, Ben Willem Mol, Khalid S Khan, Shakila Thangaratinam
BACKGROUND: Diet- and physical activity-based interventions in pregnancy have the potential to alter maternal and child outcomes. OBJECTIVES: To assess whether or not the effects of diet and lifestyle interventions vary in subgroups of women, based on maternal body mass index (BMI), age, parity, Caucasian ethnicity and underlying medical condition(s), by undertaking an individual patient data (IPD) meta-analysis. We also evaluated the association of gestational weight gain (GWG) with adverse pregnancy outcomes and assessed the cost-effectiveness of the interventions...
August 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28793779/comparative-susceptibility-of-rhesus-macaques-of-indian-and-chinese-origin-to-vaginal-shiv-transmission-as-models-for-hiv-prevention-research
#9
Ronald Veazey, Binhua Ling
Historically, Indian origin rhesus macaques (iRM) have been preferred for SIV/HIV prevention, pathogenesis, and treatment studies, yet their supply is limited. Chinese origin rhesus macaques (cRM) are currently more available yet little is known regarding the relative susceptibility of this subspecies to vaginal transmission of SIV or SHIV. Here we compared the susceptibility of 40 cRM and 21 iRM to a single vaginal challenge with SHIVsf162P. Our results showed cRM have comparable primary SHIV infection as iRM, underscoring their equal importance in studies of HIV transmission and prevention...
August 10, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28792003/vaccine-modified-nf-kb-and-gr-signaling-in-cervicovaginal-epithelium-correlates-with-protection
#10
L Shang, A J Smith, C S Reilly, L Duan, K E Perkey, S Wietgrefe, M Zupancic, P J Southern, R P Johnson, J V Carlis, A T Haase
Cervicovaginal epithelium plays a critical role in determining the outcome of virus transmission in the female reproductive tract (FRT) by initiating or suppressing transmission-facilitating mucosal immune responses in naïve and SIVmac239Δnef-vaccinated animals, respectively. In this study, we examined the very early responses of cervical epithelium within 24 h after vaginal exposure to SIV in naive and SIVmac239Δnef-vaccinated rhesus macaques. Using both ex vivo and in vivo experimental systems, we found that vaginal exposure to SIV rapidly induces a broad spectrum of pro-inflammatory responses in the epithelium associated with a reciprocal regulation of NF-kB and glucocorticoid receptor (GR) signaling pathways...
August 9, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28770842/persistent-anthrax-as-a-major-driver-of-wildlife-mortality-in-a-tropical-rainforest
#11
Constanze Hoffmann, Fee Zimmermann, Roman Biek, Hjalmar Kuehl, Kathrin Nowak, Roger Mundry, Anthony Agbor, Samuel Angedakin, Mimi Arandjelovic, Anja Blankenburg, Gregory Brazolla, Katherine Corogenes, Emmanuel Couacy-Hymann, Tobias Deschner, Paula Dieguez, Karsten Dierks, Ariane Düx, Susann Dupke, Henk Eshuis, Pierre Formenty, Yisa Ginath Yuh, Annemarie Goedmakers, Jan F Gogarten, Anne-Céline Granjon, Scott McGraw, Roland Grunow, John Hart, Sorrel Jones, Jessica Junker, John Kiang, Kevin Langergraber, Juan Lapuente, Kevin Lee, Siv Aina Leendertz, Floraine Léguillon, Vera Leinert, Therese Löhrich, Sergio Marrocoli, Kerstin Mätz-Rensing, Amelia Meier, Kevin Merkel, Sonja Metzger, Mizuki Murai, Svenja Niedorf, Hélène De Nys, Andreas Sachse, Joost van Schijndel, Ulla Thiesen, Els Ton, Doris Wu, Lothar H Wieler, Christophe Boesch, Silke R Klee, Roman M Wittig, Sébastien Calvignac-Spencer, Fabian H Leendertz
Anthrax is a globally important animal disease and zoonosis. Despite this, our current knowledge of anthrax ecology is largely limited to arid ecosystems, where outbreaks are most commonly reported. Here we show that the dynamics of an anthrax-causing agent, Bacillus cereus biovar anthracis, in a tropical rainforest have severe consequences for local wildlife communities. Using data and samples collected over three decades, we show that rainforest anthrax is a persistent and widespread cause of death for a broad range of mammalian hosts...
August 2, 2017: Nature
https://www.readbyqxmd.com/read/28763793/virion-incorporation-of-integrin-%C3%AE-4%C3%AE-7-facilitates-hiv-1-infection-and-intestinal-homing
#12
Christina Guzzo, David Ichikawa, Chung Park, Damilola Phillips, Qingbo Liu, Peng Zhang, Alice Kwon, Huiyi Miao, Jacky Lu, Catherine Rehm, James Arthos, Claudia Cicala, Myron S Cohen, Anthony S Fauci, John H Kehrl, Paolo Lusso
The intestinal mucosa is a key anatomical site for HIV-1 replication and CD4(+) T cell depletion. Accordingly, in vivo treatment with an antibody to the gut-homing integrin α4β7 was shown to reduce viral transmission, delay disease progression, and induce persistent virus control in macaques challenged with simian immunodeficiency virus (SIV). We show that integrin α4β7 is efficiently incorporated into the envelope of HIV-1 virions. Incorporated α4β7 is functionally active as it binds mucosal addressin cell adhesion molecule-1 (MAdCAM-1), promoting HIV-1 capture by and infection of MAdCAM-expressing cells, which in turn mediate trans-infection of bystander cells...
May 12, 2017: Science Immunology
https://www.readbyqxmd.com/read/28761742/implementing-precision-cancer-medicine-in-the-public-health-services-of-norway-the-diagnostic-infrastructure-and-a-cost-estimate
#13
Anne Hansen Ree, Hege G Russnes, Daniel Heinrich, Svein Dueland, Kjetil Boye, Vigdis Nygaard, Laxmi Silwal-Pandit, Olga Østrup, Eivind Hovig, Vegard Nygaard, Einar A Rødland, Sigve Nakken, Janne T Øien, Christin Johansen, Inger R Bergheim, Veronica Skarpeteig, Menaka Sathermugathevan, Torill Sauer, Marius Lund-Iversen, Klaus Beiske, Salah Nasser, Lars Julsrud, Claudius H Reisse, Espen A Ruud, Vivi Ann Flørenes, Kirsten T Hagene, Eline Aas, Hilde Lurås, Siv Johnsen-Soriano, Gry A Geitvik, Ole Christian Lingjærde, Anne-Lise Børresen-Dale, Gunhild M Mælandsmo, Kjersti Flatmark
OBJECTIVE: Through the conduct of an individual-based intervention study, the main purpose of this project was to build and evaluate the required infrastructure that may enable routine practice of precision cancer medicine in the public health services of Norway, including modelling of costs. METHODS: An eligible patient had end-stage metastatic disease from a solid tumour. Metastatic tissue was analysed by DNA sequencing, using a 50-gene panel and a study-generated pipeline for analysis of sequence data, supplemented with fluorescence in situ hybridisation to cover relevant biomarkers...
2017: ESMO Open
https://www.readbyqxmd.com/read/28758637/dna-prime-protein-boost-vaccination-elicits-robust-humoral-response-in-rhesus-macaques-using-oligomeric-simian-immunodeficiency-virus-envelope-and-advax-delta-inulin-adjuvant
#14
Veena Menon, Victor I Ayala, Sneha P Rangaswamy, Irene Kalisz, Stephen Whitney, Lindsey Galmin, Asma Ashraf, Celia LaBranche, David Montefiori, Nikolai Petrovsky, Vaniambadi S Kalyanaraman, Ranajit Pal
The partial success of the RV144 trial underscores the importance of envelope-specific antibody responses for an effective HIV-1 vaccine. Oligomeric HIV-1 envelope proteins delivered with a potent adjuvant are expected to elicit strong antibody responses with broad neutralization specificity. To test this hypothesis, two SIV envelope proteins were formulated with delta inulin-based adjuvant (Advax) and used to immunize nonhuman primates. Oligomeric gp140-gp145 from SIVmac251 and SIVsmE660 was purified to homogeneity...
July 31, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28752134/hiv-infection-of-macrophages-implications-for-pathogenesis-and-cure
#15
Kiera L Clayton, J Victor Garcia, Janice E Clements, Bruce D Walker
Although CD4(+) T cells represent the major reservoir of persistent HIV and SIV infection, accumulating evidence suggests that macrophages also contribute. However, investigations of the role of macrophages are often underrepresented at HIV pathogenesis and cure meetings. This was the impetus for a scientific workshop dedicated to this area of study, held in Cambridge, MA in January 2017. The workshop brought together experts in the fields of HIV/SIV immunology and virology, macrophage biology and immunology, and animal models of HIV/SIV infection to discuss the role of macrophages as a physiologically relevant viral reservoir, and the implications of macrophage infection for HIV pathogenesis and strategies for cure...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28750321/modeling-the-evolution-of-siv-sooty-mangabey-progenitor-virus-towards-hiv-2-using-humanized-mice
#16
Kimberly Schmitt, Dipu Mohan Kumar, James Curlin, Leila Remling-Mulder, Mark Stenglein, Shelby O'Connor, Preston Marx, Ramesh Akkina
HIV-2 is thought to have originated from an SIV progenitor native to sooty mangabeys. To model the initial human transmission and understand the sequential viral evolution, humanized mice were infected with SIVsm and serially passaged for five generations. Productive infection was seen by week 3 during the initial challenge followed by chronic viremia and gradual CD4(+) T cell decline. Viral loads increased by the 5th generation resulting in more rapid CD4(+) T cell decline. Genetic analysis revealed several amino acid substitutions that were nonsynonymous and fixed in multiple hu-mice across each of the 5 generations in the nef, env and rev regions...
July 24, 2017: Virology
https://www.readbyqxmd.com/read/28748664/long-term-efficient-control-of-siv-infection-in-macaques-is-associated-with-an-intact-intestinal-barrier
#17
Maria Daskalaki, Berit Neumann, Antonina Klippert, Kerstin Mätz-Rensing, Franz-Josef Kaup, Christiane Stahl-Hennig
Hallmarks of SIV infection are early depletion of gut CD4 T cells and diminished intestinal integrity. Comprehensive studies on colon biopsies of SIV-infected macaques efficiently controlling infection revealed that in contrast to viremic and failing controllers, elite controllers show preserved CD4 T cells, and low viral load, apoptosis, and inflammation.
August 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28748659/mauritian-cynomolgus-macaques-with-m3m4-mhc-genotype-control-sivmac251-infection
#18
Hongzhao Li, Robert W Omange, Chris Czarnecki, Jorge F Correia-Pinto, Jose Crecente-Campo, Meika Richmond, Lin Li, Nancy Schultz-Darken, Maria J Alonso, James B Whitney, Francis A Plummer, Ma Luo
BACKGROUND: Understanding natural HIV control may lead to new preventative or therapeutic strategies. Several protective major histocompatibility complex (MHC) genotypes were found in humans and rhesus macaques. Here, we report a simian immunodeficiency virus (SIV) controller MHC genotype in Mauritian cynomolgus macaques (MCMs). METHODS: Twelve MHC-genotyped MCMs were infected with SIVmac251 and monitored for viral loads and CD4+ T-cell counts. RESULTS: Two macaques with M3M4 genotype exhibited the lowest peak viral loads (log plasma SIV RNA copies/mL), nearly 3 logs lower than those in most macaques with other MHC haplotype combinations, and set point viral loads below the level of detection limit by RT-qPCR (<2 log RNA copies/mL)...
August 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28747495/hiv-and-siv-maintain-high-levels-of-infectivity-in-the-complete-absence-of-mucin-type-o-glycosylation
#19
James M Termini, Elizabeth S Church, Zachary A Silver, Stuart M Haslam, Anne Dell, Ronald C Desrosiers
A highly conserved threonine near the C-terminus of gp120 of HIV and SIV was investigated for its contributions to envelope protein function and virion infectivity. When this highly conserved Thr residue was substituted with anything other than serine (the other amino acid that can accept O-glycosylation), the resulting virus was non-infectious. We found that this Thr was critical for the association of gp120 with the virion and that amino acid substitution increased the amount of dissociated gp120 in the cell culture supernatant...
July 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28734175/cd8-t-cell-programming-by-cytomegalovirus-vectors-applications-in-prophylactic-and-therapeutic-vaccination
#20
REVIEW
Klaus Früh, Louis Picker
Vectors based on cytomegalovirus (CMV) represent a novel vaccine platform that maintains high frequencies of non-exhausted effector memory T cells in both CMV sero-positive and sero-negative individuals. In non-human primate models, CMV vectored vaccines provide unprecedented protection against simian immunodeficiency virus (SIV). Moreover, CMV vectors can be genetically altered to program highly diverse CD8+ T cell responses that differ in their epitope targeting including conventional, MHC-I restricted CD8+ T cells as well as unconventional CD8+ T cells restricted by MHC class II or non-polymorphic MHC-E...
July 19, 2017: Current Opinion in Immunology
keyword
keyword
9964
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"