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https://www.readbyqxmd.com/read/28822871/altered-language-network-in-benign-childhood-epilepsy-patients-with-spikes-from-non-dominant-side-a-resting-state-fmri-study
#1
Jiajia Fang, Sihan Chen, Cheng Luo, Qiyong Gong, Dongmei An, Dong Zhou
Benign childhood epilepsy with centrotemporal spikes (BECTS) is one of the most common childhood epilepsy syndromes, and language deficits associated with BECTS have become a hot topic. This study investigated alterations of the language network in BECTS children with spikes from the non-dominant side in comparison with healthy controls. Twenty-three children with BECTS and 20 age-matched healthy controls were enrolled. Region of interest -based whole brain functional connectivity analysis was used to identify the potential differences in the functional connectivity of the Broca's area between the two groups...
August 1, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28821846/the-effects-of-long-term-abacus-training-on-topological-properties-of-brain-functional-networks
#2
Jian Weng, Ye Xie, Chunjie Wang, Feiyan Chen
Previous studies in the field of abacus-based mental calculation (AMC) training have shown that this training has the potential to enhance a wide variety of cognitive abilities. It can also generate specific changes in brain structure and function. However, there is lack of studies investigating the impact of AMC training on the characteristics of brain networks. In this study, utilizing graph-based network analysis, we compared topological properties of brain functional networks between an AMC group and a matched control group...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821753/dynamic-reconfiguration-of-cortical-functional-connectivity-across-brain-states
#3
Iain Stitt, Karl J Hollensteiner, Edgar Galindo-Leon, Florian Pieper, Eva Fiedler, Thomas Stieglitz, Gerhard Engler, Guido Nolte, Andreas K Engel
Throughout each day, the brain displays transient changes in state, as evidenced by shifts in behavior and vigilance. While the electrophysiological correlates of brain states have been studied for some time, it remains unclear how large-scale cortico-cortical functional connectivity systematically reconfigures across states. Here, we investigate state-dependent shifts in cortical functional connectivity by recording local field potentials (LFPs) during spontaneous behavioral transitions in the ferret using chronically implanted micro-electrocorticographic (µECoG) arrays positioned over occipital, parietal, and temporal cortical regions...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821746/neural-circuitry-governing-anxious-individuals-mis-allocation-of-working-memory-to-threat
#4
Daniel M Stout, Alexander J Shackman, Walker S Pedersen, Tara A Miskovich, Christine L Larson
Dispositional anxiety is a trait-like phenotype that confers increased risk for a range of debilitating neuropsychiatric disorders. Like many patients with anxiety disorders, individuals with elevated levels of dispositional anxiety are prone to intrusive and distressing thoughts in the absence of immediate threat. Recent electrophysiological research suggests that these symptoms are rooted in the mis-allocation of working memory (WM) resources to threat-related information. Here, functional MRI was used to identify the network of brain regions that support WM for faces and to quantify the allocation of neural resources to threat-related distracters in 81 young adults...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821448/cognitive-impairment-and-gene-expression-alterations-in-a-rodent-model-of-binge-eating-disorder
#5
A Chawla, Z A Cordner, G Boersma, T H Moran
Binge eating disorder (BED) is defined as recurrent, distressing over-consumption of palatable food (PF) in a short time period. Clinical studies suggest that individuals with BED may have impairments in cognitive processes, executive functioning, impulse control, and decision-making, which may play a role in sustaining binge eating behavior. These clinical reports, however, are limited and often conflicting. In this study, we used a limited access rat model of binge-like behavior in order to further explore the effects of binge eating on cognition...
August 15, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28821393/nutritional-status-brain-network-organization-and-general-intelligence
#6
Marta K Zamroziewicz, M Tanveer Talukdar, Chris E Zwilling, Aron K Barbey
The high energy demands of the brain underscore the importance of nutrition in maintaining brain health and further indicate that aspects of nutrition may optimize brain health, in turn enhancing cognitive performance. General intelligence represents a critical cognitive ability that has been well characterized by cognitive neuroscientists and psychologists alike, but the extent to which a driver of brain health, namely nutritional status, impacts the neural mechanisms that underlie general intelligence is not understood...
August 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28821381/evidence-from-blindness-for-a-cognitively-pluripotent-cortex
#7
REVIEW
Marina Bedny
Cognitive neuroscience seeks to discover how cognitive functions are implemented in neural circuits. Studies of plasticity in blindness suggest that this mind-brain mapping is highly flexible during development. In blindness, 'visual' cortices take on higher-cognitive functions, including language and mathematics, becoming sensitive to the grammatical structure of spoken sentences and the difficulty of math equations. Visual cortex activity at rest becomes synchronized with higher-cognitive networks. Such repurposing is striking in light of the cognitive and evolutionary differences between vision, language, and mathematics...
July 8, 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28821345/evidence-from-blindness-for-a-cognitively-pluripotent-cortex
#8
REVIEW
Marina Bedny
Cognitive neuroscience seeks to discover how cognitive functions are implemented in neural circuits. Studies of plasticity in blindness suggest that this mind-brain mapping is highly flexible during development. In blindness, 'visual' cortices take on higher-cognitive functions, including language and mathematics, becoming sensitive to the grammatical structure of spoken sentences and the difficulty of math equations. Visual cortex activity at rest becomes synchronized with higher-cognitive networks. Such repurposing is striking in light of the cognitive and evolutionary differences between vision, language, and mathematics...
September 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28819796/simultaneous-eeg-pet-fmri-measurements-in-disorders-of-consciousness-an-exploratory-study-on-diagnosis-and-prognosis
#9
Daniel Golkowski, Katharina Merz, Caroline Mlynarcik, Tobias Kiel, Barbara Schorr, Alex Lopez-Rolon, Mathias Lukas, Denis Jordan, Andreas Bender, Rüdiger Ilg
Previous studies could demonstrate that functional magnetic resonance imaging (fMRI), fludeoxyglucose positron emission tomography (FDG-PET), and electroencephalography (EEG) measures contain information about patients suffering from disorders of consciousness (DOC) and thus improve the clinical diagnosis. Additionally, the technical modalities were able to predict the outcome of patients. However, most studies lack proven reproducibility in a clinical setting. We here applied a standardized combined EEG/fMRI/FDG-PET measurement to a cohort of 20 patients suffering from DOC and focused on parameters that have been demonstrated to contain information about diagnosis and prognosis of these patients...
August 17, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28819211/dynamic-local-connectivity-uncovers-altered-brain-synchrony-during-propofol-sedation
#10
Rose Dawn Bharath, Rajanikant Panda, Jitender Saini, Kamath Sriganesh, G S Umamaheswara Rao
Human consciousness is considered a result of the synchronous "humming" of multiple dynamic networks. We performed a dynamic functional connectivity analysis using resting state functional magnetic resonance imaging (rsfMRI) in 14 patients before and during a propofol infusion to characterize the sedation-induced alterations in consciousness. A sliding 36-second window was used to derive 59 time points of whole brain integrated local connectivity measurements. Significant changes in the connectivity strength (Z Corr) at various time points were used to measure the connectivity fluctuations during awake and sedated states...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819205/fast-wide-volume-functional-imaging-of-engineered-in-vitro-brain-tissues
#11
G Palazzolo, M Moroni, A Soloperto, G Aletti, G Naldi, M Vassalli, T Nieus, F Difato
The need for in vitro models that mimic the human brain to replace animal testing and allow high-throughput screening has driven scientists to develop new tools that reproduce tissue-like features on a chip. Three-dimensional (3D) in vitro cultures are emerging as an unmatched platform that preserves the complexity of cell-to-cell connections within a tissue, improves cell survival, and boosts neuronal differentiation. In this context, new and flexible imaging approaches are required to monitor the functional states of 3D networks...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819132/treatment-associated-changes-of-functional-connectivity-of-midbrain-brainstem-nuclei-in-major-depressive-disorder
#12
Gerd Wagner, Feliberto de la Cruz, Stefanie Köhler, Karl-Jürgen Bär
Previous functional magnetic resonance imaging (fMRI) studies demonstrated an abnormally coordinated network functioning in Major Depression Disorder (MDD) during rest. The main monoamine-producing nuclei within midbrain/brainstem are functionally integrated within these specific networks. Therefore, we aimed to investigate the resting-state functional connectivity (RSFC) of these nuclei in 45 MDD patients and differences between patients receiving two different classes of antidepressant drugs. Patients showed reduced RSFC from the ventral tegmental area (VTA) to dorsal anterior cingulate cortex (dACC) and stronger RSFC to the left amygdala and dorsolateral prefrontal cortex (DLPFC)...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819130/a-multielectrode-array-microchannel-platform-reveals-both-transient-and-slow-changes-in-axonal-conduction-velocity
#13
Rouhollah Habibey, Shahrzad Latifi, Hossein Mousavi, Mattia Pesce, Elmira Arab-Tehrany, Axel Blau
Due to their small dimensions, electrophysiology on thin and intricate axonal branches in support of understanding their role in normal and diseased brain function poses experimental challenges. To reduce experimental complexity, we coupled microelectrode arrays (MEAs) to bi-level microchannel devices for the long-term in vitro tracking of axonal morphology and activity with high spatiotemporal resolution. Our model allowed the long-term multisite recording from pure axonal branches in a microscopy-compatible environment...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818840/hcn4-ion-channel-function-is-required-for-early-events-that-regulate-anatomical-left-right-patterning-in-a-nodal-and-lefty-asymmetric-gene-expression-independent-manner
#14
Vaibhav P Pai, Valerie Willocq, Emily J Pitcairn, Joan M Lemire, Jean-François Paré, Nian-Qing Shi, Kelly A McLaughlin, Michael Levin
Laterality is a basic characteristic of all life forms, from single cell organisms to complex plants and animals. For many metazoans, consistent left-right asymmetric patterning is essential for the correct anatomy of internal organs, such as the heart, gut, and brain; disruption of left-right asymmetry patterning leads to an important class of birth defects in human patients. Laterality functions across multiple scales, where early embryonic, subcellular and chiral cytoskeletal events are coupled with asymmetric amplification mechanisms and gene regulatory networks leading to asymmetric physical forces that ultimately result in distinct left and right anatomical organ patterning...
August 17, 2017: Biology Open
https://www.readbyqxmd.com/read/28817956/the-role-of-intrinsic-brain-functional-connectivity-in-vulnerability-and-resilience-to-bipolar-disorder
#15
Gaelle E Doucet, Danielle S Bassett, Nailin Yao, David C Glahn, Sophia Frangou
OBJECTIVE: Bipolar disorder is a heritable disorder characterized by mood dysregulation associated with brain functional dysconnectivity. Previous research has focused on the detection of risk- and disease-associated dysconnectivity in individuals with bipolar disorder and their first-degree relatives. The present study seeks to identify adaptive brain connectivity features associated with resilience, defined here as avoidance of illness or delayed illness onset in unaffected siblings of patients with bipolar disorder...
August 18, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28817804/structural-mechanism-for-modulation-of-synaptic-neuroligin-neurexin-signaling-by-mdga-proteins
#16
Jonathan Elegheert, Vedrana Cvetkovska, Amber J Clayton, Christina Heroven, Kristel M Vennekens, Samuel N Smukowski, Michael C Regan, Wanyi Jia, Alexandra C Smith, Hiro Furukawa, Jeffrey N Savas, Joris de Wit, Jo Begbie, Ann Marie Craig, A Radu Aricescu
Neuroligin-neurexin (NL-NRX) complexes are fundamental synaptic organizers in the central nervous system. An accurate spatial and temporal control of NL-NRX signaling is crucial to balance excitatory and inhibitory neurotransmission, and perturbations are linked with neurodevelopmental and psychiatric disorders. MDGA proteins bind NLs and control their function and interaction with NRXs via unknown mechanisms. Here, we report crystal structures of MDGA1, the NL1-MDGA1 complex, and a spliced NL1 isoform. Two large, multi-domain MDGA molecules fold into rigid triangular structures, cradling a dimeric NL to prevent NRX binding...
August 16, 2017: Neuron
https://www.readbyqxmd.com/read/28817580/criticality-predicts-maximum-irregularity-in-recurrent-networks-of-excitatory-nodes
#17
Yahya Karimipanah, Zhengyu Ma, Ralf Wessel
A rigorous understanding of brain dynamics and function requires a conceptual bridge between multiple levels of organization, including neural spiking and network-level population activity. Mounting evidence suggests that neural networks of cerebral cortex operate at a critical regime, which is defined as a transition point between two phases of short lasting and chaotic activity. However, despite the fact that criticality brings about certain functional advantages for information processing, its supporting evidence is still far from conclusive, as it has been mostly based on power law scaling of size and durations of cascades of activity...
2017: PloS One
https://www.readbyqxmd.com/read/28817568/an-optimal-strategy-for-epilepsy-surgery-disruption-of-the-rich-club
#18
Marinho A Lopes, Mark P Richardson, Eugenio Abela, Christian Rummel, Kaspar Schindler, Marc Goodfellow, John R Terry
Surgery is a therapeutic option for people with epilepsy whose seizures are not controlled by anti-epilepsy drugs. In pre-surgical planning, an array of data modalities, often including intra-cranial EEG, is used in an attempt to map regions of the brain thought to be crucial for the generation of seizures. These regions are then resected with the hope that the individual is rendered seizure free as a consequence. However, post-operative seizure freedom is currently sub-optimal, suggesting that the pre-surgical assessment may be improved by taking advantage of a mechanistic understanding of seizure generation in large brain networks...
August 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28817417/brain-processing-of-the-temporal-dimension-of-acute-pain-in-short-term-memory
#19
Mina Khoshnejad, Mathieu Roy, Kristina Martinu, Jen-I Chen, Julien Cohen-Adad, Simon Grondin, Pierre Rainville
The dynamics of noxious sensation shapes pain perception, yet the memory of the temporal dimension of pain remains almost completely unexplored. Here, brain activity during the memory of pain duration was contrasted with that associated with the memory of pain intensity using functional magnetic resonance imaging (fMRI) and a delayed-reproduction task. Participants encoded, maintained during a short delay, and reproduced (1) the 'duration' of pain (i.e. onset-to-offset), (2) the 'dynamics' of pain (i.e. evolution of pain over time), or (3) the intensity of pain (i...
July 3, 2017: Pain
https://www.readbyqxmd.com/read/28816657/a-dynamic-regression-approach-for-frequency-domain-partial-coherence-and-causality-analysis-of-functional-brain-networks
#20
Lipeng Ning, Yogesh Rathi
Coherence and causality measures are often used to analyze the influence of one region on another during analysis of functional brain networks. The analysis methods usually involve a regression problem where the signal of interest is decomposed into a mixture of regressor and a residual signal. In this paper, we revisit this basic problem and present solutions that provide the minimal-entropy residuals for different types of regression filters, such as causal, instantaneously causal and noncausal filters. Using optimal prediction theory, we derive several novel frequency-domain expressions for partial coherence, causality and conditional causality analysis...
August 14, 2017: IEEE Transactions on Medical Imaging
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