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neutrophil to lymphocyte ratio mCRPC

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https://www.readbyqxmd.com/read/27790145/systemic-immune-inflammation-index-predicts-the-clinical-outcome-in-patients-with-mcrpc-treated-with-abiraterone
#1
Cristian Lolli, Orazio Caffo, Emanuela Scarpi, Michele Aieta, Vincenza Conteduca, Francesca Maines, Emanuela Bianchi, Francesco Massari, Antonello Veccia, Vincenzo E Chiuri, Gaetano Facchini, Ugo De Giorgi
Background: A systemic immune-inflammation index (SII) based on neutrophil (N), lymphocyte (L), and platelet (P) counts has shown a prognostic impact in several solid tumors. The aim of this study is to evaluate the prognostic role of SII in metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone post docetaxel. Patients and Methods: We retrospectively reviewed consecutive mCRPC patients treated with abiraterone after docetaxel in our Institutions. X-tile 3.6.1 software, cut-off values of SII, neutrophil-to-lymphocyte ratio (NLR) defined as N/L and platelets-to-lymphocyte ratio (PLR) as P/L...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27368058/neutrophil-to-lymphocyte-ratio-predicts-psa-response-and-prognosis-in-prostate-cancer-a-systematic-review-and-meta-analysis
#2
Jian Cao, Xuan Zhu, Xiaokun Zhao, Xue-Feng Li, Ran Xu
An unprecedented advance has been seen in castration-resistant prostate cancer (CRPC) treatments in the past few years. With a number of novel agents were approved, there is a pressing need to develop improved prognostic biomarkers to facilitate the personalised selection and sequencing of these novel agents. Emerging evidence indicates that the neutrophil-to-lymphocyte ratio (NLR) is associated with poorer survival in patients with prostate cancer (PCa). However, the importance of the NLR for the prediction of the PSA response (PSARS) and biochemical recurrence (BCR) has been largely neglected...
2016: PloS One
https://www.readbyqxmd.com/read/26912340/prognostic-significance-of-neutrophil-to-lymphocyte-ratio-in-prostate-cancer-evidence-from-16-266-patients
#3
Xiaobin Gu, Xianshu Gao, Xiaoying Li, Xin Qi, Mingwei Ma, Shangbin Qin, Hao Yu, Shaoqian Sun, Dong Zhou, Wen Wang
This study was aimed to investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in patients with prostate cancer (PCa). A meta-analysis including 14 publications (15 cohorts) with 16,266 patients was performed to evaluate the association between NLR and overall survival (OS), progression-free survival (PFS)/recurrence-free survival (RFS) in PCa using hazard ratio (HR) and 95% confidence intervals (95% CI). The combining data showed that increased NLR predict poor OS (HR = 1.38, 95%CI: 1...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26829012/severe-neutropenia-during-cabazitaxel-treatment-is-associated-with-survival-benefit-in-men-with-metastatic-castration-resistant-prostate-cancer-mcrpc-a-post-hoc-analysis-of-the-tropic-phase-iii-trial
#4
RANDOMIZED CONTROLLED TRIAL
Alexander Meisel, Stefanie von Felten, Deborah R Vogt, Heike Liewen, Ronald de Wit, Johann de Bono, Oliver Sartor, Frank Stenner-Liewen
BACKGROUND: Cabazitaxel significantly improves overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC) progressing during or after docetaxel, but is associated with a higher rate of grade ≥3 neutropenia compared with docetaxel. We thus examined the relationship between cabazitaxel-induced grade ≥3 neutropenia, baseline neutrophil-lymphocyte ratio (NLR) and treatment outcomes. METHODS: Data from the experimental arm of the TROPIC phase 3 trial which randomly assigned men with mCRPC to cabazitaxel or mitoxantrone every 3 weeks, both combined with daily prednisone, were analysed...
March 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/26817900/prognostic-role-of-neutrophil-to-lymphocyte-ratio-in-prostate-cancer-a-systematic-review-and-meta-analysis
#5
REVIEW
Xiaotao Yin, Yi Xiao, Fanglong Li, Siyong Qi, Zhaoyang Yin, Jiangping Gao
Inflammation is increasingly reported to be associated with the prognosis of patients with cancers. And the prognostic role of neutrophil-to-lymphocyte ratio (NLR) in patients with prostate cancer (PCa) remains inconsistent. Therefore, we conducted this systematic review and meta-analysis to obtain a more reliable assessment of prognostic significance of NLR in PCa.A comprehensive literature research regarding the association of NLR and prognosis of PCa was performed through PubMed, Embase, Cochrane Central, and Web of Science...
January 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25538172/baseline-neutrophil-lymphocyte-ratio-nlr-is-associated-with-survival-and-response-to-treatment-with-second-line-chemotherapy-for-advanced-prostate-cancer-independent-of-baseline-steroid-use
#6
RANDOMIZED CONTROLLED TRIAL
D Lorente, J Mateo, A J Templeton, Z Zafeiriou, D Bianchini, R Ferraldeschi, A Bahl, L Shen, Z Su, O Sartor, J S de Bono
BACKGROUND: The neutrophil-lymphocyte ratio (NLR), proposed as an indicator of cancer-related inflammation, has known prognostic value in prostate cancer. We examine its association with survival (OS) and response in patients treated with second-line chemotherapy. METHODS: We analysed patients with metastatic castration-resistant prostate cancer (mCRPC) treated in the TROPIC trial, evaluating cabazitaxel versus mitoxantrone. Cox regression models were used to investigate the association of baseline NLR (BLNLR) with OS and the significance of a change in NLR count with treatment...
April 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/25515657/neutrophil-to-lymphocyte-ratio-as-a-prognostic-biomarker-for-men-with-metastatic-castration-resistant-prostate-cancer-receiving-first-line-chemotherapy-data-from-two-randomized-phase-iii-trials
#7
RANDOMIZED CONTROLLED TRIAL
R J van Soest, A J Templeton, F E Vera-Badillo, F Mercier, G Sonpavde, E Amir, B Tombal, M Rosenthal, M A Eisenberger, I F Tannock, R de Wit
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), a marker of host inflammation, has been associated with poor outcome in several solid tumors. Here, we investigated associations of the derived NLR (dNLR) and duration of initial androgen deprivation therapy (ADT) with survival of men with metastatic castration-resistant prostate cancer (mCRPC) receiving first-line chemotherapy. PATIENTS AND METHODS: Data from the multinational randomized phase III studies VENICE and TAX327 included a total of 2230 men with mCRPC randomized to receive first-line chemotherapy, and were used as training and validation sets, respectively...
April 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/24995769/simple-prognostic-score-for-metastatic-castration-resistant-prostate-cancer-with-incorporation-of-neutrophil-to-lymphocyte-ratio
#8
Arnoud J Templeton, Carmel Pezaro, Aurelius Omlin, Mairéad G McNamara, Raya Leibowitz-Amit, Francisco E Vera-Badillo, Gerhardt Attard, Johann S de Bono, Ian F Tannock, Eitan Amir
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), a marker of inflammation, has been reported to be a poor prognostic indicator in prostate cancer. Here we explore the use of the NLR to establish a simple prognostic score for men with metastatic castration-resistant prostate cancer (mCRPC) treated with docetaxel. METHODS: In the training cohort, the NLR and other known prognostic variables were evaluated among a cohort of chemotherapy-naïve patients treated with thrice-weekly docetaxel at the Princess Margaret Cancer Centre...
November 1, 2014: Cancer
https://www.readbyqxmd.com/read/24806399/prognostic-impact-of-the-neutrophil-to-lymphocyte-ratio-in-men-with-metastatic-castration-resistant-prostate-cancer
#9
COMPARATIVE STUDY
Guru Sonpavde, Gregory R Pond, Andrew J Armstrong, Stephen J Clarke, Janette L Vardy, Arnoud J Templeton, Shaw-Ling Wang, Jolanda Paolini, Isan Chen, Edna Chow-Maneval, Mariajose Lechuga, Matthew R Smith, M Dror Michaelson
BACKGROUND: We retrospectively evaluated the prognostic impact of neutrophil-lymphocyte ratio (NLR) as a marker for inflammatory and immune state in men with progressive metastatic castration resistant prostate cancer (mCRPC) following docetaxel. METHODS: The SUN-1120 phase III trial comparing prednisone combined with sunitinib (n = 584) or placebo (n = 289) for mCRPC following docetaxel-based chemotherapy was evaluated. The arms were combined for analysis, since no difference was observed in the primary endpoint of overall survival (OS)...
October 2014: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/24529213/association-of-pretreatment-neutrophil-to-lymphocyte-ratio-nlr-and-overall-survival-os-in-patients-with-metastatic-castration-resistant-prostate-cancer-mcrpc-treated-with-first-line-docetaxel
#10
Philipp Nuhn, Ajay M Vaghasia, Jatinder Goyal, Xian C Zhou, Michael A Carducci, Mario A Eisenberger, Emmanuel S Antonarakis
OBJECTIVE: To determine whether the pretreatment neutrophil-to-lymphocyte ratio (NLR), a measure of systemic inflammatory response, is associated with overall survival (OS) in men receiving chemotherapy with docetaxel for metastatic castration-resistant prostate cancer (mCRPC). PATIENTS AND METHODS: Records from 238 consecutive patients who were treated with first-line docetaxel-containing chemotherapy for mCRPC at a single high-volume centre from 1998 to 2010 (and who had adequate information to enable calculation of NLR) were reviewed...
December 2014: BJU International
https://www.readbyqxmd.com/read/24458472/clinical-variables-associated-with-psa-response-to-abiraterone-acetate-in-patients-with-metastatic-castration-resistant-prostate-cancer
#11
R Leibowitz-Amit, A J Templeton, A Omlin, C Pezaro, E G Atenafu, D Keizman, F Vera-Badillo, J-A Seah, G Attard, J J Knox, S S Sridhar, I F Tannock, J S de Bono, A M Joshua
BACKGROUND: Abiraterone acetate (abiraterone) prolongs overall survival (OS) in patients with metastatic castration-resistant prostate cancer (mCRPC). This study's objective was to retrospectively identify factors associated with prostate-specific antigen (PSA) response to abiraterone and validate them in an independent cohort. We hypothesized that the neutrophil/lymphocyte ratio (NLR), thought to be an indirect manifestation of tumor-promoting inflammation, may be associated with response to abiraterone...
March 2014: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/22971522/pretreatment-neutrophil-to-lymphocyte-ratio-in-metastatic-castration-resistant-prostate-cancer-patients-treated-with-ketoconazole-association-with-outcome-and-predictive-nomogram
#12
Daniel Keizman, Maya Gottfried, Maya Ish-Shalom, Natalie Maimon, Avivit Peer, Avivit Neumann, Eli Rosenbaum, Svetlana Kovel, Roberto Pili, Victoria Sinibaldi, Michael A Carducci, Hans Hammers, Mario A Eisenberger, Avishay Sella
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), an inflammation marker, is prognostic in several cancers. We assessed the association between the pretreatment NLR and outcome of patients with metastatic castration-resistant prostate cancer (mCRPC) treated with the CYP17 inhibitor ketoconazole. METHODS: This was an international, retrospective study of 156 mCRPC patients treated with ketoconazole. The independent effect of the pretreatment NLR and factors associated with treatment outcome were determined by multivariate analysis...
2012: Oncologist
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