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https://www.readbyqxmd.com/read/28632411/the-effect-of-dexamethasone-intravitreal-implant-on-retinal-nerve-fiber-layer-in-patients-diagnosed-with-branch-retinal-vein-occlusion
#1
Orhan Ayar, Atilla Alpay, Yaran Koban, Mehmet Orcun Akdemir, Serpil Yazgan, Sılay Canturk Ugurbas, Suat Hayri Ugurbas
PURPOSE: To evaluate the effect of a single dose of intravitreal dexamethasone (DEX) implant on retinal nerve fiber layer (RNFL) thickness in patients with branch retinal vein occlusion (BRVO) in a 6-month period. MATERIALS AND METHODS: This retrospective observational study included the patients with BRVO who received intravitreal DEX implant and whose assessment included the baseline RNFL thickness measurements. The data of 26 eyes of 24 patients were retrospectively analyzed...
June 20, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28630791/corticosteroid-treatment-in-diabetic-macular-edema
#2
REVIEW
Burcu Nurözler Tabakcı, Nurten Ünlü
Diabetic macular edema is the most common cause of visual impairment in patients with diabetes mellitus. The pathogenesis of macular edema is complex and multifactorial. For many years, laser photocoagulation has been considered the standard therapy for the treatment of diabetic macular edema; however, few patients achieve significant improvements in visual acuity. Today the intravitreal administration of anti-inflammatory or anti-angiogenic agents together with the use of laser photocoagulation represents the standard of care for the treatment of this complication...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28622270/dexamethasone-intravitreal-implant-for-the-treatment-of-recalcitrant-macular-edema-after-rhegmatogenous-retinal-detachment-repair
#3
Aristomenis Thanos, Bozho Todorich, Yoshihiro Yonekawa, Thanos D Papakostas, Tahsin Khundkar, Dean Eliott, Ashvani B Dass, George A Williams, Antonio Capone, Lisa J Faia, Jeremy D Wolfe, Tarek S Hassan, Alan J Ruby
PURPOSE: To investigate the efficacy of the intravitreal dexamethasone implant as the treatment for recalcitrant macular edema after successful rhegmatogenous retinal detachment repair. METHODS: A retrospective review of the medical records was performed on 17 consecutive patients (17 eyes) with recalcitrant macular edema associated with rhegmatogenous retinal detachment repair who were treated with a single or multiple injections of an intravitreal dexamethasone 0...
June 15, 2017: Retina
https://www.readbyqxmd.com/read/28620704/ranibizumab-versus-dexamethasone-implant-for-central-retinal-vein-occlusion-the-ranidex-study
#4
Irini Chatziralli, George Theodossiadis, Stamatina A Kabanarou, Efstratios Parikakis, Tina Xirou, Panagiotis Mitropoulos, Panagiotis Theodossiadis
PURPOSE: To compare intravitreal ranibizumab and dexamethasone implant in patients with macular edema (ME) secondary to central retinal vein occlusion (CRVO). METHODS: Participants were 42 treatment naive patients with ME due to CRVO, who received either intravitreal 0.5 mg ranibizumab (n = 25) or intravitreal 0.7 mg dexamethasone implant (n = 17). The main outcomes included the mean change in best corrected visual acuity (BCVA) and central subfield thickness (CST) at month 12 compared to baseline in the two groups...
June 15, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28601910/the-clinical-outcomes-of-surgical-management-of-anterior-chamber-migration-of-a-dexamethasone-implant-ozurdex%C3%A2
#5
Hyunseung Kang, Min Woo Lee, Suk Ho Byeon, Hyoung Jun Koh, Sung Chul Lee, Min Kim
PURPOSE: Our purpose was to describe the clinical course, and individualized management approaches, of patients with migration of a dexamethasone implant into the anterior chamber. METHODS: This was a retrospective review of four patients with seven episodes of anterior chamber migration of a dexamethasone implant. RESULTS: After 924 intravitreal dexamethasone injections, anterior migration of the implant occurred in four eyes of four patients (0...
June 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28599333/-macular-edema-in-uveitis-steroids-or-vegf-inhibitors
#6
Carsten Heinz, Arnd Heiligenhaus
Macular edema in uveitis patients is certainly the most frequent complication leading to a permanent and irreversible reduction in vision during the course of the disease. Thanks to optical coherence tomography (OCT) technology and fluorescein angiography (FAG), significantly more macular edemas are detected. Macular edema can be found in various uveitis varieties and can show different clinical patterns. All macular edema should be treated. Macular edema with active inflammation usually reacts very well to general uveitis treatment...
June 9, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28577137/ischemic-index-changes-in-diabetic-retinopathy-after-intravitreal-dexamethasone-implant-using-ultra-widefield-fluorescein-angiography-a-pilot-study
#7
Lea Querques, Mariacristina Parravano, Riccardo Sacconi, Alessandro Rabiolo, Francesco Bandello, Giuseppe Querques
AIMS: To investigate the effect of dexamethasone intravitreal implant on peripheral ischemia in patients affected by diabetic macular edema (DME). METHODS: Patients with treatment-naïve diabetic retinopathy (DR) undergoing intravitreal dexamethasone implant for DME between October 2015 and March 2017 were enrolled. Patients underwent a comprehensive ocular examination at baseline (<2 weeks before treatment) and 10 ± 2 weeks after dexamethasone implant including best-corrected visual acuity (BCVA), intraocular pressure, optical coherence tomography, ultra-widefield (UWF) retinography and UWF fluorescein angiography (UWFA)...
June 2, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28574436/qualitative-and-quantitative-assessment-of-vascular-changes-in-diabetic-macular-edema-after-dexamethasone-implant-using-optical-coherence-tomography-angiography
#8
Lisa Toto, Rossella D'Aloisio, Marta Di Nicola, Giuseppe Di Martino, Silvio Di Staso, Marco Ciancaglini, Daniele Tognetto, Leonardo Mastropasqua
The aim of this study was to investigate retinal and choriocapillaris vessel changes in diabetic macular edema (DME) after the intravitreal dexamethasone implant (IDI) using optical coherence tomography angiography (OCTA). Moreover, a comparison between morphological and functional parameters of DME and healthy patients was performed. Twenty-five eyes of 25 type 2 diabetic retinopathy patients complicated by macular edema (DME group) and 25 healthy subjects (control group) were enrolled. Superficial capillary plexus density (SCPD) and deep capillary plexus density (DCPD) in the foveal and parafoveal areas, choricapillary density (CCD) and optic disc vessel density (ODVD) were detected using OCTA at baseline and after 7, 30, 60, 90 and 120 days post injection...
June 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28571808/nanoparticle-loaded-biodegradable-light-responsive-in-situ-forming-injectable-implants-for-effective-peptide-delivery-to-the-posterior-segment-of-the-eye
#9
Rohit Bisht, Jagdish K Jaiswal, Ilva D Rupenthal
Diseases affecting the posterior segment the eye, such as age-related macular degeneration (AMD), are the leading cause of blindness worldwide. Conventional dosage forms, such as eye drops, have to surmount several elimination mechanisms and complex barriers to achieve therapeutic concentrations at the target site often resulting in low anterior segment bioavailability (ca. 2-5%) with generally none of the drug reaching posterior segment tissues. Thus, frequent intravitreal injections are currently required to treat retinal conditions which have been associated with poor patient compliance due to pain, risk of infection, hemorrhages, retinal detachment and high treatment related costs...
June 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28570735/accuracy-of-billing-codes-used-in-the-therapeutic-care-of-diabetic-retinopathy
#10
Marisa Lau, Jonathan L Prenner, Alexander J Brucker, Brian L VanderBeek
Importance: Insurance billing claim databases represent a growing field of scientific inquiry within ophthalmology. Validating the accuracy of billing claim codes used during the care of diabetic retinopathy is a necessary precursor to fully understanding the underlying data and subsequent results of these types of studies. Objective: To determine the accuracy of diagnostic, procedural, and therapeutic billing codes used in the treatment of diabetic retinopathy...
June 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28558371/early-effects-of-dexamethasone-implant-on-macular-morphology-and-visual-function-in-patients-with-diabetic-macular-edema
#11
Daniele Veritti, Valentina Sarao, Francesco Galiazzo, Paolo Lanzetta
PURPOSE: To evaluate the early effects of dexamethasone implant in patients with diabetic macular edema (DME). METHODS: Eyes with DME were prospectively included in the study. Best-corrected visual acuity (BCVA) measurement, complete ophthalmic evaluation, and spectral-domain optical coherence tomography were performed at baseline and 1, 2, 3, 7, 14, 21, 28, 60, and 90 days after treatment. RESULTS: Twenty-three eyes of 20 patients were included in the study...
May 31, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28558353/antiangiogenic-activity-of-plga-lupeol-implants-for-potential-intravitreal-applications
#12
Daniel Crístian Ferreira Soares, Diogo Coelho de Paula Oliveira, Luciola Silva Barcelos, Alan Sales Barbosa, Lorena Carla Vieira, Danyelle M Townsend, Domenico Rubello, André Luis Branco de Barros, Lucienir Pains Duarte, Armando Silva-Cunha
Uncontrolled angiogenesis is directly associated with ocular diseases such as macular degeneration and diabetic retinopathy. Implantable polymeric drug delivery systems have been proposed for intravitreal applications and in the present work, we evaluated the antiangiogenic potential of PLGA ocular implants loaded with the triterpene lupeol using in vitro and in vivo models. The drug/polymer physiochemical properties of the lupeol-loaded PLGA were validated as functionally similar using differential scanning calorimetry, Fourier transform infrared spectroscopy, and scanning electron microscopy...
May 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28557602/systemic-steroid-sparing-effect-of-intravitreal-dexamethasone-implant-in-chronic-noninfectious-uveitic-macular-edema
#13
Claudia Fabiani, Antonio Vitale, Giacomo Emmi, Giuseppe Lopalco, Lorenzo Vannozzi, Daniela Bacherini, Silvana Guerriero, Rosa Anna Favale, Fiorella Fusco, Rossella Franceschini, Bruno Frediani, Florenzo Iannone, Mauro Galeazzi, Gian Marco Tosi, Luca Cantarini
PURPOSE: To evaluate the effectiveness and the systemic corticosteroid sparing effect of a single intravitreal dexamethasone (DEX) implant in patients with chronic noninfectious uveitic macular edema (UME). METHODS: Data from 22 eyes treated with DEX implant for UME related to systemic or ocular-confined noninfectious diseases were retrospectively analyzed. RESULTS: The mean systemic prednisone (or equivalent) dosage significantly decreased at 3- and 6-month follow-up evaluations compared to baseline (P = 0...
May 30, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28553669/simultaneous-dexamethasone-intravitreal-implant-and-anti-vegf-therapy-for-neovascular-age-related-macular-degeneration-resistant-to-anti-vegf-monotherapy
#14
Bozho Todorich, Aristomenis Thanos, Yoshihiro Yonekawa, Gerta Mane, Madeleine Hasbrook, Benjamin J Thomas, Maria A Woodward, George A Williams, Antonio Capone, Jeremy D Wolfe, Lisa J Faia, Tarek S Hassan
PURPOSE: To evaluate the efficacy of a dexamethasone intravitreal implant in combination with intravitreal anti-VEGF agents for treatment resistant neovascular age-related macular degeneration (nvAMD). METHODS: This study was designed as a single-center, retrospective interventional case series. Consecutive patients with treatment-resistant nvAMD underwent simultaneous combined injection of anti-VEGF agent and dexamethasone intravitreal implant. Eighteen patients with mean age of 81...
2017: J Vitreoretin Dis
https://www.readbyqxmd.com/read/28551163/therapies-for-macular-edema-associated-with-branch-retinal-vein-occlusion-a-report-by-the-american-academy-of-ophthalmology
#15
Justis P Ehlers, Stephen J Kim, Steven Yeh, Jennifer E Thorne, Prithvi Mruthyunjaya, Scott D Schoenberger, Sophie J Bakri
PURPOSE: To evaluate the available evidence on the ocular safety and efficacy of current therapeutic alternatives for the management of macular edema (ME) secondary to branch retinal vein occlusion (BRVO). METHODS: Literature searches were last conducted on January 31, 2017, in PubMed with no date restrictions and limited to articles published in English, and in the Cochrane Database without language limitations. The searches yielded 321 citations, of which 109 were reviewed in full text and 27 were deemed appropriate for inclusion in this assessment...
May 24, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28535531/comparison-of-intravitreal-ranibizumab-aflibercept-and-dexamethasone-implant-after-bevacizumab-failure-in-macular-edema-secondary-to-retinal-vascular-occlusions
#16
Joel Hanhart, Yaacov Rozenman
PURPOSE: To compare the visual and anatomic outcomes of macular edema secondary to retinal vein occlusion after switching from bevacizumab to ranibizumab, aflibercept, or dexamethasone implant. METHODS: Fifteen eyes were switched to ranibizumab, 12 to aflibercept, and 10 to dexamethasone. At 3, 6, 9, and 12 months, the outcome measures were visual acuity (VA) and central macular thickness (CMT). RESULTS: One year after the switch, CMT decreased from 430...
May 24, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28524135/-selective-symptomatic-therapy-of-macular-edema-due-to-occlusive-processes-in-retinal-venous-system
#17
M M Bikbov, R R Fayzrakhmanov, T R Gil'manshin
AIM: to evaluate the effect of dexamethasone intravitreal implant on the functional state of the eye in macular edema associated with central retinal vein occlusion. MATERIAL AND METHODS: The study included two groups of patients: group 1 (control group) - 8 patients (16 eyes) without ocular pathology and group 2 (study group) - 8 patients (8 eyes) with macular edema on the background of newly diagnosed thrombosis of the central retinal vein. All the patients from the study group underwent insertion of an intravitreal dexamethasone implant - Ozurdex...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28494699/lens-capsule-perforation-without-inflammation-in-4-rabbits-from-intravitreal-injection-studies
#18
Cindy Farman, Chris Schuetz, Florence Lorget, Vladimir Bantseev, David Calise, Evan A Thackaberry
Historically, it was thought that lens protein was sequestered, and injury to the lens capsule causing release of lens material into the eye would always result in ocular inflammation. Currently, it is believed that lens antigens are recognized as self, subject to normal T-cell tolerance. Three different single-dose intravitreal injection/implantation studies of 4 different test materials, ranging from 4 to 6 weeks in length, were performed in New Zealand White rabbits. The test materials included polymer microspheres, polymer rods, a solvent, and a hydrogel...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28492410/dexamethasone-intravitreal-implant-for-choroidal-neovascularization-during-pregnancy
#19
Vittorio Capuano, Rita Serra, Hassiba Oubraham, Olivia Zambrowski, Danielle Amana, Jennifer Zerbib, Eric H Souied, Giuseppe Querques
PURPOSE: To describe the management of active choroidal neovascularization (CNV) during pregnancy with the use of a dexamethasone intravitreal implant (DXI) (Ozurdex). METHODS: Case series of active CNV treated with DXI with at least 12-month follow-up retrospectively analyzed at 2 high-volume referral centers in France. Medical records and multimodal macular imaging were evaluated. RESULTS: Three eyes of 3 patients (age 30.0 ± 3.6 years) were included...
May 10, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28489707/intravitreal-dexamethasone-ozurdex-implant-for-radiation-maculopathy-secondary-to-stereotactic-radiotherapy-for-posterior-uveal-melanoma
#20
Irem Koc, Sibel Kadayifcilar, Hayyam Kiratli, Bora Eldem
PURPOSE: To evaluate the efficacy of 0.7 mg intravitreal dexamethasone implant in the treatment of radiation maculopathy after stereotactic radiotherapy for posterior uveal melanoma. METHODS: Retrospective chart review of seven eyes of seven consecutive patients was performed. Extracted data included age, sex, initial and follow-up visual acuities and central macular thickness values, intraocular pressure, follow-up time, number of implants, and time elapsed from radiotherapy to implantation...
May 9, 2017: Retinal Cases & Brief Reports
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