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https://www.readbyqxmd.com/read/28433977/pupilloplasty-to-prevent-dexamethasone-intravitreal-implant-migration-to-anterior-chamber
#1
Joana Medeiros Pinto, Carlos Marques-Neves
No abstract text is available yet for this article.
April 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28432109/early-response-to-ranibizumab-predictive-of-functional-outcome-after-dexamethasone-for-unresponsive-diabetic-macular-oedema
#2
Maria Vittoria Cicinelli, Michele Cavalleri, Lea Querques, Alessandro Rabiolo, Francesco Bandello, Giuseppe Querques
PURPOSE: To analyse the effects of intravitreal dexamethasone implant in patients suffering from diabetic macular oedema (DME) on the basis of their visual and functional response to antivascular endothelial growth factor (VEGF) loading dose, in order to early shift to corticosteroids in poorly responding patients. DESIGN: Retrospective monocentric study. METHODS: Data of patients with diabetes shifted to 0.7 mg dexamethasone implant after three injections of ranibizumab (RNB) and followed-up to 12 months were reviewed...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28430329/ahmed-valves-vs-trabeculectomy-combined-with-pans-plana-vitrectomy-for-neovascular-glaucoma-with-vitreous-hemorrhage
#3
Menghua H Wang, Qiuming M Li, Hongtao T Dong, Shuqian Q Dong, Yang Li, Chunyan Y Zheng
PURPOSE: Vitreous hemorrhage is common in advanced neovascular glaucoma (NVG), which has poor visual prognosis. This study aimed to compare the efficacy of 23-G pars planar vitrectomy (PPV) combined with either Ahmed glaucoma valve (AGV) implantation or trabeculectomy after intravitreal ranibizumab (IVR) treatment for NVG with vitreous hemorrhage. METHODS: This retrospective, nonrandomized study included 33 eyes of 33 patients with NVG with vitreous hemorrhage. After IVR treatment for 3-7 days, 18 eyes underwent PPV + AGV (AGV group) and 15 underwent PPV + trabeculectomy (trabeculectomy group)...
April 14, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28426623/intravitreal-dexamethasone-implantation-in-patients-with-different-morphological-diabetic-macular-edema-having-insufficient-response-to-ranibizumab
#4
Havva Kaldırım, Serpil Yazgan, Kursat Atalay, Ceren Gurez, Fatma Savur
PURPOSE: To evaluate the effectiveness of a single intravitreal injection of dexamethasone implant in resistant diabetic macular edema that have different morphological types. METHODS: In this retrospective study, 31 patients (35 eyes) with persistent diabetic macular edema, who underwent a single injection of dexamethasone implant, were evaluated. Diabetic macular edema was classified into three types: diffuse retinal thickening (n = 10), cystoid macular edema (n = 13), and serous retinal detachment (n = 12)...
April 19, 2017: Retina
https://www.readbyqxmd.com/read/28425224/nanocarrier-mediated-retinal-drug-delivery-overcoming-ocular-barriers-to-treat-posterior-eye-diseases
#5
REVIEW
Rohit Bisht, Abhirup Mandal, Jagdish K Jaiswal, Ilva D Rupenthal
Effective drug delivery to the retina still remains a challenge due to ocular elimination mechanisms and complex barriers that selectively limit the entry of drugs into the eye. To overcome these barriers, frequent intravitreal injections are currently used to achieve high drug concentrations in vitreous and retina. However, these repetitive injections may result in several side effects. Recent advancements in the field of nanoparticle-based drug delivery could overcome some of these unmet needs and various preclinical studies conducted to date have demonstrated promising results of nanotherapies in the treatment of retinal diseases...
April 20, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28404670/intravitreal-dexamethasone-implant-in-radiation-induced-macular-oedema
#6
Luisa Frizziero, Raffaele Parrozzani, Sara Trainiti, Elisabetta Pilotto, Giacomo Miglionico, Serena Pulze, Edoardo Midena
AIMS: To evaluate the efficacy and duration of activity of a single intravitreal dexamethasone implant in patients affected by radiation maculopathy. METHODS: Thirteen consecutive eyes of 13 patients affected by radiation maculopathy secondary to eye irradiation for a primary uveal melanoma (Iodine-125 brachytherapy) and treated with a single intravitreal 0.7 mg dexamethasone implant were retrospectively evaluated. Each patient underwent full ophthalmological examination, including fluorescein angiography and spectral domain optical coherence tomography (SD-OCT), even in en-face modality...
April 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28393031/efficacy-and-safety-of-intravitreal-ranibizumab-with-panretinal-photocoagulation-followed-by-trabeculectomy-compared-with-ahmed-glaucoma-valve-implantation-in-neovascular-glaucoma
#7
Jin-Tao Sun, Hai-Jing Liang, Meng An, Da-Bo Wang
AIM: To evaluate the efficacy and safety of intravitreal ranibizumab (IVR) with panretinal photocoagulation (PRP) followed by trabeculectomy compared with Ahmed glaucoma valve (AGV) implantation in neovascular glaucoma (NVG). METHODS: This was a retrospective comparative study. We reviewed the cases of a total of 45 eyes from 45 NVG patients among which 23 eyes underwent AGV implantation and the other 22 underwent trabeculectomy. The causes of neovascular glaucoma included: diabetic retinopathy (25 eyes), and retinal vein occlusion (20 eyes)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28392675/clinical-utility-of-intravitreal-fluocinolone-acetonide-iluvien-%C3%A2-implant-in-the-management-of-patients-with-chronic-diabetic-macular-edema-a-review-of-the-current-literature
#8
REVIEW
Habiba Saedon, Astha Anand, Yit C Yang
The first-line therapy for patients with center-involving diabetic macular edema (DME) is with intravitreal anti-vascular endothelial growth factor (VEGF) agents, with or without adjunctive macular laser treatment. However, a significant proportion of patients have persistent and recurrent edema despite repeated anti-VEGF injections. The fluocinolone acetonide (FA) 190 μg intravitreal implant has been shown in pivotal clinical trials to be efficacious for the treatment of DME and has been approved in many countries for use in patients who have not responded to first-line therapy...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28391041/cyclodextrins-and-topical-drug-delivery-to-the-anterior-and-posterior-segments-of-the-eye
#9
Thorsteinn Loftsson, Einar Stefánsson
It is generally believed that it is virtually impossible to obtain therapeutic drug concentrations in the posterior segment of the eye after topical application of aqueous, low viscosity eye drops. Thus, intravitreal drug injections and drug implants are currently used to treat diseases in the posterior segment such as macular edema. Here it is described how, through proper analysis of the drug permeation barriers and application of well-known pharmaceutical excipients, aqueous eye drops are designed that can deliver lipophilic drugs to the posterior segment as well as how such eye drops can maintain high drug concentrations in the anterior segment...
April 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28386497/bilateral-severe-sterile-inflammation-with-hypopyon-after-simultaneous-intravitreal-triamcinolone-acetonide-and-aflibercept-injection-in-a-patient-with-bilateral-marked-rubeosis-associated-with-ocular-ischemic-syndrome
#10
Ceren Durmaz Engin, Ziya Ayhan, Süleyman Men, Aylin Yaman, A Osman Saatci
We report the clinical course of a diabetic patient with bilateral cataract and rubeosis in association with ocular ischemic syndrome and initially treated him with simultaneous intravitreal 2 mg aflibercept and 2 mg triamcinolone acetonide injection at the same setting prior to planned cataract surgery and further photocoagulation. However, sterile anterior segment inflammation characterized by hypopyon occurred four days apart in OU. Right eye developed the sterile inflammation at the third postinjection day and the left eye developed the sterile inflammation at the seventh postinjection day (two days after the uneventful cataract surgery with intraocular lens implantation) without any pain or significant redness...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28380178/what-do-cochrane-systematic-reviews-say-about-diabetic-retinopathy
#11
Vania Mozetic, Julia Pozzetti Daou, Ana Luiza Cabrera Martimbianco, Rachel Riera
CONTEXT AND OBJECTIVE: Diabetic retinopathy is a disease caused by increased permeability of retinal vessels. Its incidence and prevalence have been increasing due to urbanization, greater life expectancy and the habits of modern life. Its onset is insidious and it may lead to blindness in 75% of individuals who have been diabetic for more than 20 years. The aim here was to evaluate the evidence from Cochrane systematic reviews on interventions relating to diabetic retinopathy. DESIGN AND SETTING: Review of systematic reviews, conducted at Cochrane Brazil...
January 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28378252/intravitreal-dexamethasone-implant-for-recalcitrant-cystoid-macular-edema-secondary-to-retinitis-pigmentosa-a-pilot-study
#12
Aditya Sudhalkar, Laurent Kodjikian, Nishikant Borse
BACKGROUND: To determine the utility of the intravitreal dexamethasone implant as therapy for cystoid macular edema (CME) secondary to retinitis pigmentosa (RP) recalcitrant to carbonic anhydrase inhibitor therapy over 2 years as a pilot study. METHODS: This was a prospective case series. Patients who showed either an incomplete or no response to topical dorzolamide for at least 1 month and oral acetazolamide therapy for at least 15 days were recruited for the study with informed consent...
April 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28376554/-retinal-vein-occlusion-which-treatment-when
#13
A Bajor, A Pielen, L Danzmann
According to the latest findings, macular oedema due to retinal vein occlusion is best treated safely and effectively with near-term intravitreal anti-VEGF therapy (aflibercept, bevacizumab [off label], ranibizumab). After an initial upload of 3 monthly injections of anti-VEGF, the decision on re-injection should be based on OCT (rather than on visual acuity). After initial monthly injections, the "pro-re-nata" (PRN) and the "treat-and-extend" regimens have been predominantly used in the further course of therapy...
April 4, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28376511/anterior-segment-migration-of-dexamethasone-implant-risk-factors-complications-and-management
#14
REVIEW
Ehsan Rahimy, Rahul N Khurana
PURPOSE OF REVIEW: To describe the risk factors, clinical course, and complications related to anterior segment migration of a dexamethasone (DEX) intravitreal implant, and review over potential management strategies. RECENT FINDINGS: Recent reports have demonstrated that migration of a DEX implant into the anterior chamber may occur in patients with higher risk ocular characteristics. Although a relatively rare occurrence, DEX implant migration carries the possibility of inducing potentially vision-threatening corneal endothelial decompensation and edema...
May 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28375791/intravitreal-dexamethasone-implant-for-treatment-of-serous-macular-detachment-in-central-retinal-vein-occlusion
#15
Ahmet Elbay, Hakan Ozdemir, Arif Koytak, Arif Melikov
PURPOSE: To evaluate the effect of intravitreal dexamethasone implant (Ozurdex) treatment on serous macular detachment (SMD) in patients with nonischemic central retinal vein occlusion (CRVO). METHODS: Retrospective, interventional, noncomparative case series was conducted. Twenty-four eyes of 24 patients with macular edema (ME) and SMD secondary to nonischemic CRVO made up the study population. Patients who had received intravitreal triamcinolone and/or antivascular endothelial growth factor treatment and/or had undergone retinal photocoagulation were excluded from the study...
April 4, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28367039/efficacy-and-safety-of-intravitreal-dexamethasone-implants-for-treatment-of-refractory-diabetic-macular-edema
#16
Erkan Unsal, Kadir Eltutar, Pınar Sultan, Sezin Ozdogan Erkul, Ozen Ayranci Osmanbasoglu
PURPOSE: To evaluate the safety and efficacy of intravitreal dexamethasone (IVD) implants in eyes with diabetic macular edema that did not respond to previous treatment. METHODS: We included 46 eyes of 46 patients in this retrospective study. Each month, we recorded patient visual acuity with logarithm of the minimum angle of resolution using the Early Treatment Diabetic Retinopathy Study chart, central macular thickness measurements with optical coherence tomography, intraocular pressure (IOP), and posttreatment complication occurrence...
April 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28367038/dexamethasone-intravitreal-implant-rescue-treatment-for-bevacizumab-refractory-macular-edema-secondary-to-branch-retinal-vein-occlusion
#17
Kyou Ho Lee, Eui Chun Kang, Hyoung Jun Koh
PURPOSE: To evaluate the prognostic factors and outcomes of dexamethasone intravitreal implant (DEX implant) for intravitreal bevacizumab refractory macular edema secondary to branch retinal vein occlusion (BRVO). METHODS: This was a retrospective, interventional case series. Medical records were reviewed, and a total of 38 eyes that were treated with DEX implant for macular edema secondary to BRVO that did not respond to at least two consecutive intravitreal bevacizumab injections (IBIs) were included...
April 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28366074/intravitreal-bevacizumab-and-dexamethasone-implant-for-treatment-of-chronic-diabetic-macular-edema
#18
Emre Güler, Yüksel Totan, Fatma Betül Güragaç
OBJECTIVE: To evaluate anatomical and functional outcomes of intraviteal bevacizumab (IVB) in patients with chronic diabetic macular edema (DME), and the effectivity and safety of dexamethasone implant in those unresponsive to regular IVB treatment. METHODS: Thirty-five eyes of 35 patients (16 male and 19 female) with chronic DME (central foveal thickness (CFT)  > 275 μm, duration  > 6 months) received three injections of 2.5 mg IVB with six-week intervals...
June 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28360511/health-related-quality-of-life-visual-function-and-treatment-satisfaction-following-intravitreal-dexamethasone-implant-for-diabetic-macular-edema
#19
Jayashree Ramu, Irini Chatziralli, Yit Yang, Geeta Menon, Clare Bailey, Michael Eckstein, Phil Hykin, Sobha Sivaprasad
PURPOSE: The aim of this study was to explore and describe quantitatively patient-reported outcome measures (PROMs), ie, health-related quality of life (QoL), visual function and treatment satisfaction, in patients with diabetic macular edema (DME) receiving two different regimens of Ozurdex (intravitreal dexamethasone implant). METHODS: In this multicenter, prospective study, 100 patients with center-involving refractory DME were randomized 1:1 to either five monthly fixed dosing or optical coherence tomography (OCT)-guided pro re nata (PRN) regimen of dexamethasone intravitreal implant therapy...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28337065/acute-bacterial-endophthalmitis-following-intravitreal-dexamethasone-implant-a-case-report-and-review-of-literature
#20
Neha Goel
Endophthalmitis following intravitreal dexamethasone (DEX) implant has been rarely reported. This report describes the case of a 70-year-old male who underwent intravitreal DEX implant injection under aseptic conditions, for diabetic macular edema. He developed a clinical picture suggestive of endophthalmitis within 2 weeks of the injection, and vitreous culture grew coagulase negative Staphylococcus. He was treated with intravitreal antibiotics followed by pars plana vitrectomy and removal of the implant...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
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