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https://www.readbyqxmd.com/read/28092796/global-open-data-management-in-metabolomics
#1
REVIEW
Kenneth Haug, Reza M Salek, Christoph Steinbeck
Chemical Biology employs chemical synthesis, analytical chemistry and other tools to study biological systems. Recent advances in both molecular biology such as next generation sequencing (NGS) have led to unprecedented insights towards the evolution of organisms' biochemical repertoires. Because of the specific data sharing culture in Genomics, genomes from all kingdoms of life become readily available for further analysis by other researchers. While the genome expresses the potential of an organism to adapt to external influences, the Metabolome presents a molecular phenotype that allows us to asses the external influences under which an organism exists and develops in a dynamic way...
January 13, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28092374/the-movers-and-shapers-in-immune-privilege-of-the-cns
#2
REVIEW
Britta Engelhardt, Peter Vajkoczy, Roy O Weller
Discoveries leading to an improved understanding of immune surveillance of the central nervous system (CNS) have repeatedly provoked dismissal of the existence of immune privilege of the CNS. Recent rediscoveries of lymphatic vessels within the dura mater surrounding the brain, made possible by modern live-cell imaging technologies, have revived this discussion. This review emphasizes the fact that understanding immune privilege of the CNS requires intimate knowledge of its unique anatomy. Endothelial, epithelial and glial brain barriers establish compartments in the CNS that differ strikingly with regard to their accessibility to immune-cell subsets...
January 16, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28091521/mechanisms-of-intrinsic-resistance-and-acquired-susceptibility-of-pseudomonas-aeruginosa-isolated-from-cystic-fibrosis-patients-to-temocillin-a-revived-antibiotic
#3
Hussein Chalhoub, Daniel Pletzer, Helge Weingart, Yvonne Braun, Michael M Tunney, J Stuart Elborn, Hector Rodriguez-Villalobos, Patrick Plésiat, Barbara C Kahl, Olivier Denis, Mathias Winterhalter, Paul M Tulkens, Françoise Van Bambeke
The β-lactam antibiotic temocillin (6-α-methoxy-ticarcillin) shows stability to most extended spectrum β-lactamases, but is considered inactive against Pseudomonas aeruginosa. Mutations in the MexAB-OprM efflux system, naturally occurring in cystic fibrosis (CF) isolates, have been previously shown to reverse this intrinsic resistance. In the present study, we measured temocillin activity in a large collection (n = 333) of P. aeruginosa CF isolates. 29% of the isolates had MICs ≤ 16 mg/L (proposed clinical breakpoint for temocillin)...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28087774/the-origin-of-mitochondrial-cristae-from-alphaproteobacteria
#4
Sergio A Muñoz-Gómez, Jeremy G Wideman, Andrew J Roger, Claudio H Slamovits
Mitochondria are the respiratory organelles of eukaryotes and their evolutionary history is deeply intertwined with that of eukaryotes. The compartmentalization of respiration in mitochondria occurs within cristae, whose evolutionary origin has remained unclear. Recent discoveries, however, have revived the old notion that mitochondrial cristae could have had a pre-endosymbiotic origin. Mitochondrial cristae are likely homologous to the intracytoplasmic membranes (ICMs) used by diverse alphaproteobacteria for harnessing energy...
January 12, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28079064/lasing-action-from-photonic-bound-states-in-continuum
#5
Ashok Kodigala, Thomas Lepetit, Qing Gu, Babak Bahari, Yeshaiahu Fainman, Boubacar Kanté
In 1929, only three years after the advent of quantum mechanics, von Neumann and Wigner showed that Schrödinger's equation can have bound states above the continuum threshold. These peculiar states, called bound states in the continuum (BICs), manifest themselves as resonances that do not decay. For several decades afterwards the idea lay dormant, regarded primarily as a mathematical curiosity. In 1977, Herrick and Stillinger revived interest in BICs when they suggested that BICs could be observed in semiconductor superlattices...
January 11, 2017: Nature
https://www.readbyqxmd.com/read/28078766/lost-in-transformation-reviving-ethics-of-care-in-hospital-cultures-of-evidence-based-healthcare
#6
Annelise Norlyk, Anita Haahr, Pia Dreyer, Bente Martinsen
Drawing on previous empirical research, we provide an exemplary narrative to illustrate how patients have experienced hospital care organized according to evidence-based fast-track programmes. The aim of this paper was to analyse and discuss if and how it is possible to include patients' individual perspectives in an evidence-based practice as seen from the point of view of nursing theory. The paper highlights two conflicting courses of development. One is a course of standardization founded on evidence-based recommendations, which specify a set of rules that the patient must follow rigorously...
January 12, 2017: Nursing Inquiry
https://www.readbyqxmd.com/read/28077843/orpha-orphic-functions-and-the-orphic-analyst-winnicott-s-regression-to-dependence-in-the-language-of-ferenczi
#7
Hayuta Gurevich
Early developmental trauma is imprinted in the psyche by survival fragmentation and dissociation. Traumatized patients need the analyst to be actively involved and allow for regression to dependence in order to strengthen, create and construct their psychic functioning and structure so that environmental failures will be contained and not rupture continuity of being. I suggest that Ferenczi's and Winnicott's ideas about regression to dependence in analysis are fundamental contributions to these quests, and that Ferenczi set the foundation, which Winnicott further explored and developed...
December 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28067509/rotational-dynamics-of-quantum-state-selected-symmetric-top-molecules-in-non-resonant-femtosecond-laser-fields
#8
Sizuo Luo, Wenhui Hu, Jiaqi Yu, Ruihan Zhu, Lanhai He, Xiaokai Li, Pan Ma, Chuncheng Wang, Fuchun Liu, Wim G Roeterdink, Steven Stolte, Dajun Ding
Rotational dynamics of quantum state selected and un-selected CH3I molecules in intense femtosecond laser fields has been studied. The orientation and alignment evolutions are derived from a pump-probe measurement and in good agreement with the numerical results from the time dependent Schrödinger equation (TDSE) calculation. The different rotational transitions through nonresonant Raman process have been assigned from the Fourier analysis of the orientation and alignment revivals. These revivals are derived from a pump-probe measurement and in good agreement with the numerical results from the time dependent Schr¨odinger equation (TDSE) calculation...
January 9, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28065976/refractory-diabetes-focus-on-the-obvious
#9
Sanjay Kalra, Vipin Talwar
Refractory diabetes, characterized by poor glycaemic control despite adequate treatment, is an important entity. In this condition, even the best therapeutic regimes tailored for rapid symptomatic relief and attainment of glycaemic goals may not work. The need is to revive the clinical angle of endocrinology, including a detailed history, thorough examination, judicious use of investigations and patient specific management plan, along with quality control by self and peer assessment.
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28050779/a-current-perspective-on-cancer-immune-therapy-step-by-step-approach-to-constructing-the-magic-bullet
#10
REVIEW
Gabriele D'Errico, Heather L Machado, Bruno Sainz
Immunotherapy is the new trend in cancer treatment due to the selectivity, long lasting effects, and demonstrated improved overall survival and tolerance, when compared to patients treated with conventional chemotherapy. Despite these positive results, immunotherapy is still far from becoming the perfect magic bullet to fight cancer, largely due to the facts that immunotherapy is not effective in all patients nor in all cancer types. How and when will immunotherapy overcome these hurdles? In this review we take a step back to walk side by side with the pioneers of immunotherapy in order to understand what steps need to be taken today to make immunotherapy effective across all cancers...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28044224/improvement-of-glucoamylase-production-for-raw-starch-digestion-in-aspergillus-niger-f-01-by-maltose-stearic-acid-ester
#11
Haiyan Sun, Ming Peng
OBJECTIVES: To investigate the role of maltose stearic acid ester (MSAE) for improving raw-starch-digesting glucoamylase (RSDG) production by Aspergillus niger F-01 and its regulatory mechanism. RESULTS: RSDG activity was enhanced 8.3-fold by adding 5 g MSAE to 1 l basal medium at the beginning of the culture. RSDG biosynthesis nearly ceased by adding 100 μg actinomycin D/ml or 50 μg cycloheximide/ml in a 48 h culture in the basal medium. RSDG biosynthesis was restarted by adding MSAE in the culture repressed by actinomycin D...
January 2, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28042734/vulvar-and-vaginal-atrophy-as-viewed-by-the-spanish-revive-participants-symptoms-management-and-treatment-perceptions
#12
S Palacios, M J Cancelo, C Castelo Branco, P Llaneza, F Molero, R Sanchez Borrego
OBJECTIVES: To gain a deeper comprehension of current vulvovaginal atrophy (VVA) knowledge among Spanish postmenopausal women. METHODS: An online survey (REVIVE) was conducted in four European countries with an overall sample of 768 participants included in Spain. Perceptions, experiences and needs of Spanish postmenopausal women in terms of sexual and vaginal health were reported. RESULTS: Vaginal dryness was the most common VVA symptom in Spain (81%)...
January 2, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28039547/phylogenetic-relationships-in-the-family-streptomycetaceae-using-multi-locus-sequence-analysis
#13
David P Labeda, Christopher A Dunlap, Xiaoying Rong, Ying Huang, James R Doroghazi, Kou-San Ju, William W Metcalf
The family Streptomycetaceae, notably species in the genus Streptomyces, have long been the subject of investigation due to their well-known ability to produce secondary metabolites. The emergence of drug resistant pathogens and the relative ease of producing genome sequences has renewed the importance of Streptomyces as producers of new natural products and resulted in revived efforts in isolating and describing strains from novel environments. A previous large study of the phylogeny in the Streptomycetaceae based on 16S rRNA gene sequences provided a useful framework for the relationships among species, but did not always have sufficient resolution to provide definitive identification...
December 30, 2016: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28035892/regional-diversity-and-diversification-in-mammals
#14
Antonin Machac, Catherine H Graham
The effects of regional diversity on diversification remain controversial. The classic hypothesis that diversification decelerates as regional diversity increases has been recently revived. Yet, there is little geographic evidence for slower diversification across regions of high diversity, and diversity is often thought to promote diversification through its effects on ecological divergence and speciation. Here, we use the newest phylogeny for mammals (4,990 species) and two different methods to test the effects of regional diversity on diversification...
January 2017: American Naturalist
https://www.readbyqxmd.com/read/28035111/comparison-of-who-mark-iii-and-hrp-ii-elisa-for-in-vitro-sensitivity-of-plasmodium-falciparum
#15
Supriya Sharma, Neelima Mishra, Neena Valecha, Anupkumar R Anvikar
BACKGROUND & OBJECTIVES: Antimalarial drug resistance is a serious challenge to malaria control worldwide. In vitro sensitivity assays provide an early indication of emerging drug resistance. In vitro susceptibility of field and culture adapted Plasmodium falciparum isolates to different antimalarials was compared using two Methods: World Health Organization (WHO) micro-test (MARK III) and histidine rich protein II (HRP II) based enzyme- linked immunosorbent assay (ELISA). METHODS: In total, 50 P...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28025901/the-bottom-of-the-universe-flat-earth-science-in-the-age-of-encounter
#16
James J Allegro
This essay challenges the dominance of the spherical earth model in fifteenth- and early-sixteenth-century Western European thought. It examines parallel strains of Latin and vernacular writing that cast doubt on the existence of the southern hemisphere. Three factors shaped the alternate accounts of the earth as a plane and disk put forward by these sources: (1) the unsettling effects of maritime expansion on scientific thought; (2) the revival of interest in early Christian criticism of the spherical earth; and (3) a rigid empirical stance toward entities too large to observe in their entirety, including the earth...
December 1, 2016: History of Science; An Annual Review of Literature, Research and Teaching
https://www.readbyqxmd.com/read/28013204/modelling-clinical-systemic-lupus-erythematosus-similarities-differences-and-success-stories
#17
REVIEW
Teja Celhar, Anna-Marie Fairhurst
Mouse models of SLE have been indispensable tools to study disease pathogenesis, to identify genetic susceptibility loci and targets for drug development, and for preclinical testing of novel therapeutics. Recent insights into immunological mechanisms of disease progression have boosted a revival in SLE drug development. Despite promising results in mouse studies, many novel drugs have failed to meet clinical end points. This is probably because of the complexity of the disease, which is driven by polygenic predisposition and diverse environmental factors, resulting in a heterogeneous clinical presentation...
December 24, 2016: Rheumatology
https://www.readbyqxmd.com/read/28012653/reconstructing-the-historical-water-regime-of-the-contributing-basins-to-the-hawizeh-marsh-implications-of-water-control-structures
#18
Prasad Daggupati, Raghavan Srinivasan, Yihun Taddele Dile, Deepa Verma
The Hawizeh marsh, a unique wetland which is part of the Mesopotamian marshes, is recognized as a wetland of international importance. The marsh has been shrinking and there has been little research into its degradation. This study aims to reconstruct historical water regimes in the contributing basins (Tigris and Karkheh river Basins, TKRB) to investigate factors that have affected the wellbeing of the marsh. The Soil and Water Assessment Tool (SWAT) was used for this study. The model was calibrated and validated using nine river gauging stations...
December 21, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28002856/-the-changing-value-of-mother-s-milk-feeding-premature-and-sick-newborns-since-the-late-19th-century
#19
A Sunder-Plaßmann
In the 1960s/early 70s there was a widespread conviction in West Germany that mother's milk was no longer essential even for premature infants given the availability of improved industrial milk products. But today the superiority of human milk is again undisputed, and progress in neonatology has created a growing target group of extremely premature infants who show clear benefits from being fed with human milk, particularly regarding improved outcomes. Currently there is a revival of donor milk banks (FMB)...
December 2016: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/27999812/integrative-characterization-of-toxic-response-of-zebra-fish-danio-rerio-to-deltamethrin-based-on-ache-activity-and-behavior-strength
#20
Qing Ren, Tingting Zhang, Shangge Li, Zongming Ren, Meiyi Yang, Hongwei Pan, Shiguo Xu, Li Qi, Tae-Soo Chon
In order to characterize the toxic response of zebra fish (Danio rerio) to Deltamethrin (DM), behavior strength (BS) and muscle AChE activity of zebra fish were investigated. The results showed that the average values of both BS and AChE activity showed a similarly decreased tendency as DM concentration increased, which confirmed the dose-effect relationship, and high and low levels of AChE and BS partly matched low and high levels of exposure concentrations in self-organizing map. These indicated that AChE and BS had slight different aspects of toxicity although overall trend was similar...
2016: BioMed Research International
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