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https://www.readbyqxmd.com/read/29792665/highly-conductive-and-robust-3d-host-with-excellent-alkali-metal-infiltration-boosts-ultra-stable-lithium-and-sodium-metal-anodes
#1
Wan-Sheng Xiong, Yu Xia, Yun Jiang, Yuyang Qi, Weiwei Sun, Dan He, Yumin Liu, Xingzhong Zhao
The direct utilization of metallic lithium and sodium as the anodes for rechargeable batteries would be highly advantageous, which has been considered as one of the most promising choices for next-generation high-energy-density storage devices. Although the induced safety concerns, inferior rate and cycling performance severely hinder the commercialization of lithium-metal batteries (LMB) and sodium-metal batteries (SMB), the recent development of nanotechnology-based solutions really revives the lithium/sodium metal anodes for high-energy batteries...
May 24, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29788468/caviar-an-r-package-for-checking-displaying-and-processing-wood-formation-monitoring-data
#2
Cyrille B K Rathgeber, Philippe Santenoise, Henri E Cuny
In the last decade, the pervasive question of climate change impacts on forests has revived investigations on intra-annual dynamics of wood formation, involving disciplines such as plant ecology, tree physiology and dendrochronology. This resulted in the creation of many research groups working on this topic worldwide and a rapid increase in the number of studies and publications. Wood-formation-monitoring studies are generally based on a common conceptual model describing xylem cell formation as the succession of four differentiation phases (cell division, cell enlargement, cell wall thickening and mature cells)...
May 19, 2018: Tree Physiology
https://www.readbyqxmd.com/read/29783024/a-pooled-analysis-of-the-phase-3-revive-trials-randomized-double-blind-studies-to-evaluate-the-safety-and-efficacy-of-iclaprim-versus-vancomycin-for-treatment-of-acute-bacterial-skin-and-skin-structure-infections
#3
David B Huang, G Ralph Corey, Thomas L Holland, Thomas Lodise, William O'Riordan, Mark H Wilcox, Thomas M File, Matthew Dryden, Barbara Balser, Eve Desplats, Antoni Torres
BACKGROUND: Iclaprim, a diaminopyrimidine antibiotic, was compared with vancomycin for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSIs) in two studies (REVIVE-1 and REVIVE-2). OBJECTIVES: We explored the efficacy and tolerability of iclaprim in a pooled analysis of results from both studies. METHODS: REVIVE-1 and REVIVE-2 were Phase 3, double-blind, randomized (1:1), multicenter, active-controlled, non-inferiority (margin of 10%) trials, each designed to enroll 600 patients a piece with ABSSSI...
May 18, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29779686/a-2ma-old-baboon-like-monkey-from-northern-greece-and-new-evidence-to-support-the-paradolichopithecus-procynocephalus-synonymy-primates-cercopithecidae
#4
Dimitris S Kostopoulos, Franck Guy, Zoi Kynigopoulou, George D Koufos, Xavier Valentin, Gildas Merceron
A new fossil cranium of a large papionin monkey from the Lower Pleistocene site of Dafnero-3 in Western Macedonia, Greece, is described by means of outer and inner morphological and metric traits using high-resolution micro-computed tomography. Comparisons with modern cercopithecids and contemporaneous Eurasian fossil taxa suggest that the new cranium could equally be ascribed to either the Eurasian Paradolichopithecus or to the East Asian Procynocephalus. The combination of the available direct and indirect fossil evidence, including the new cranium from Dafnero, revives an earlier hypothesis that considers these two sparsely documented genera as synonyms...
May 17, 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29776321/addressing-hiv-in-zambia-through-traditional-games
#5
Janet Njelesani, Donald Njelesani
There has been a proliferation of organizations in Zambia touting the mobilization of traditional games as a tool to prevent HIV. However, there is a dearth of evidence on how culturally important activities like traditional games are being incorporated into programing. The purpose of this study was to explore how traditional games are used as a strategy to prevent HIV in Zambia. This qualitative study generated data from 17 case studies of HIV programs operating in Lusaka, Zambia. Observations of the programs were conducted and 44 interviews with program staff were completed...
May 18, 2018: AIDS Care
https://www.readbyqxmd.com/read/29774633/a-simple-and-cost-efficient-adherent-culture-platform-for-human-gastric-primary-cells-as-an-in-vitro-model-for-helicobacter-pylori-infection
#6
Samaneh Saberi, Behshad Pournasr, Zahra Farzaneh, Maryam Esmaeili, Mahmoud Eshagh Hosseini, Hossein Baharvand, Marjan Mohammadi
BACKGROUND: Most two- dimensional in vitro models for studying host- H. pylori interactions rely on tumor-derived cell lines, which harbor malignant alterations. The recent development of human gastric organoids has overcome this limitation and provides a highly sophisticated, yet costly, short-term model for H. pylori infection, with restricted use in low-budget centers. METHOD: Tissue specimens from upper, middle, and lower stomachs of H. pylori-negative volunteers were collectively dispersed and cultured on mouse embryonic fibroblast (MEF) or collagen-coated plates...
May 17, 2018: Helicobacter
https://www.readbyqxmd.com/read/29772071/to-test-or-not-to-test-the-value-of-toxicology-in-a-delayed-overdose-death
#7
Erin E Walsh, Elisa N Shoff, Mary Elizabeth Zaney, George W Hime, Fintan Garavan, Diane M Boland
A case demonstrating the necessity of thorough death investigation processes where toxicology plays an active role is presented. A 33-year-old white man presented to the emergency room in respiratory distress after an overdose episode where he was revived on the scene by fire rescue. His condition continued to deteriorate and he expired 6 days after the initial incident. No admission specimens were available for testing; however, there were specimens drawn 4 and 5 days after the incident. Drug paraphernalia from the scene was obtained by the laboratory through collaboration with local law enforcement...
May 17, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29761122/bortezomib-treatment-for-severe-refractory-anti-nmda-receptor-encephalitis
#8
Yong-Won Shin, Soon-Tae Lee, Tae-Joon Kim, Jin-Sun Jun, Kon Chu
Objective: To evaluate the therapeutic potential of bortezomib, a proteasome inhibitor that target plasma cells, in order to revive stalled recovery in patients with anti- N -methyl-d-aspartate (NMDA) receptor encephalitis who remain bedridden even after aggressive immunotherapy. Methods: We consecutively enrolled patients with anti-NMDA receptor encephalitis who remained bedridden after first-line immunotherapy (steroids and intravenous immunoglobulin), second-line immunotherapy (rituximab), and tocilizumab treatment, and treated them with subcutaneous bortezomib...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29757357/the-revival-of-the-gini-importance
#9
Stefano Nembrini, Inke R König, Marvin N Wright
Motivation: Random forests are fast, flexible and represent a robust approach to analyze high dimensional data. A key advantage over alternative machine learning algorithms are variable importance measures, which can be used to identify relevant features or perform variable selection. Measures based on the impurity reduction of splits, such as the Gini importance, are popular because they are simple and fast to compute. However, they are biased in favor of variables with many possible split points and high minor allele frequency...
May 10, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29756917/hyperfine-structure-induced-depolarization-of-impulsively-aligned-i_-2-molecules
#10
Esben F Thomas, Anders A Søndergaard, Benjamin Shepperson, Niels E Henriksen, Henrik Stapelfeldt
A moderately intense 450 fs laser pulse is used to create rotational wave packets in gas phase I_{2} molecules. The ensuing time-dependent alignment, measured by Coulomb explosion imaging with a delayed probe pulse, exhibits the characteristic revival structures expected for rotational wave packets but also a complex nonperiodic substructure and decreasing mean alignment not observed before. A quantum mechanical model attributes the phenomena to coupling between the rotational angular momenta and the nuclear spins through the electric quadrupole interaction...
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29755481/-phage-transplantation-in-allotransplantation-possible-treatment-in-graft-versus-host-disease
#11
Andrzej Górski, Ewa Jończyk-Matysiak, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Jan Borysowski
Graft-versus-host disease, both acute and chronic (aGvHD, cGvHD) remains a major complication in patients undergoing hematopoietic cell transplantation (HCT) and a significant therapeutic challenge, as many patients do not respond adequately to presently available therapy. Increasing antimicrobial resistance has greatly revived interest in using bacterial viruses (phages) to combat antibiotic-resistant bacteria. In recent years, evidence has accumulated indicating that phages also have anti-inflammatory and immunomodulatory activities...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29755204/cryopreservation-studies-of-an-artificial-co-culture-between-the-cobalamin-requiring-green-alga-lobomonas-rostrata-and-the-bacterium-mesorhizobium-loti
#12
Christian J A Ridley, John G Day, Alison G Smith
Algal-bacterial co-cultures, rather than cultures of algae alone, are regarded as having the potential to enhance productivity and stability in industrial algal cultivation. As with other inocula in biotechnology, to avoid loss of production strains, it is important to develop preservation methods for the long-term storage of these cultures, and one of the most commonly used approaches is cryopreservation. However, whilst there are many reports of cryopreserved xenic algal cultures, little work has been reported on the intentional preservation of both algae and beneficial bacteria in xenic cultures...
2018: Journal of Applied Phycology
https://www.readbyqxmd.com/read/29754120/promoting-healthy-lives-and-well-being-for-all-the-contribution-of-the-international-college-of-person-centered-medicine-icpcm
#13
G N Christodoulou, J E Mezzich, C R Cloninger, N Christodoulou, E Villar, J Appleyard, M Botbol
This article defines the scope of Person-Centered Medicine, traces its roots in ancient conceptions, explains the reasons for the revival of this perspective in our times, and highlights the contribution of the International College of Person-Centered Medicine (ICPCM) in the promotion of the personcentered perspective in health and disease. The value of communication is underlined with reference to both diagnosis and treatment. The concept of Health is considered historically and the inclusiveness, holistic vista and positive health orientation of the WHO definition of Health (1948) is underlined...
January 2018: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29745903/system-based-strategies-for-p53-recovery
#14
Muhammad Rizwan Azam, Sahar Fazal, Mukhtar Ullah, Aamer I Bhatti
The authors have proposed a systems theory-based novel drug design approach for the p53 pathway. The pathway is taken as a dynamic system represented by ordinary differential equations-based mathematical model. Using control engineering practices, the system analysis and subsequent controller design is performed for the re-activation of wild-type p53. p53 revival is discussed for both modes of operation, i.e. the sustained and oscillatory. To define the problem in control system paradigm, modification in the existing mathematical model is performed to incorporate the effect of Nutlin...
June 2018: IET Systems Biology
https://www.readbyqxmd.com/read/29736994/high-z-sensitized-plastic-scintillators-a-review
#15
REVIEW
Tibor Jacob Hajagos, Chao Liu, Nerine J Cherepy, Qibing Pei
The need for affordable and reliable radiation detectors has prompted significant investment in new radiation detector materials, due to concerns about national security and nuclear nonproliferation. Plastic scintillators provide an affordable approach to large volume detectors, yet their performance for high-energy gamma radiation is severely limited by the small radiation stopping power inherent to their low atomic number. Although some sensitization attempts with organometallics were made in the 1950s to 1960s, the concomitant decrease in light yield has limited the usefulness of these sensitized detectors...
May 7, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29731468/-a-new-business-in-the-world-the-telegraph-privacy-and-the-u-s-constitution-in-the-nineteenth-century
#16
Thomas Jepsen
Disclosures about electronic surveillance by the U.S. National Security Agency have revived interest in issues of communications privacy and Fourth Amendment rights. In the early days of the telegraph, there was no legal protection afforded to the privacy of telegraphic communication, and seizures of telegraphic dispatches figured in major events of the nineteenth century in the United States. Attempts to protect the content of telegrams by defining a customer/operator "privilege" under common law were rejected by the courts, as were attempts to protect the confidentiality of telegraphic communications through an analogy with the postal service...
2018: Technology and Culture
https://www.readbyqxmd.com/read/29730057/adoptive-t-cell-therapy-points-to-consider
#17
REVIEW
Cassian Yee
Adoptive Cell Therapy (ACT) has enjoyed a revival in recent years with the approval of CAR T cells for the treatment of patients with B cell malignancies. Advancing the use of adoptively transferred T cells for the treatment of patients with solid tumor and other hematologic malignancies however, will require addressing numerous effector cell intrinsic as well as tumor micro environmental hurdles and exploiting a broader ACT platform that includes not only engineered CAR-T cells, but also other forms of ACT including Endogenous T Cell (ETC) and Tumor-infiltrating Lymphocyte (TIL) therapy...
May 2, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29728392/small-low-but-potent-the-complex-regulatory-role-of-the-small-rna-solb-on-solventogenesis-in-clostridium-acetobutylicum
#18
Alexander J Jones, Alan G Fast, Michael Clupper, Eleftherios T Papoutsakis
The recently revived Clostridium acetobutylicum based Acetone-Butanol-Ethanol (ABE) fermentation is widely celebrated and studied for its impact on industrial biotechnology. C. acetobutylicum has been extensively studied and engineered, yet critical areas of the molecular basis of how solvent formation is regulated remain unresolved. The core solventogenic genes ( adhE1/aad , ctfA , ctfB , adc ) are coded on the sol locus of the pSOL1 megaplasmid, whose loss leads to asporogenous, "degenerate" cells...
May 4, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29716221/excited-state-non-adiabatic-dynamics-of-the-smallest-polyene-trans-1-3-butadiene-i-time-resolved-photoelectron-photoion-coincidence-spectroscopy
#19
Andrey E Boguslavskiy, Oliver Schalk, Niklas Gador, William J Glover, Toshifumi Mori, Thomas Schultz, Michael S Schuurman, Todd J Martínez, Albert Stolow
The ultrafast excited state dynamics of the smallest polyene, trans-1,3-butadiene, were studied by femtosecond time-resolved photoelectron-photoion coincidence (TRPEPICO) spectroscopy. The evolution of the excited state wavepacket, created by pumping the bright 1 Bu (ππ*) electronic state at its origin of 216 nm, is projected via one- and two-photon ionization at 267 nm onto several ionization continua. The results are interpreted in terms of Koopmans' correlations and Franck-Condon factors for the excited and cationic states involved...
April 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29714711/direct-cp-violation-in-k-sup-0-sup-%C3%A2-%C3%AF-%C3%AF-standard-model-status
#20
Hector Gisbert, Antonio Pich
In 1988 the NA31 experiment presented the first evidence of direct CP violation in the K<sup>0</sup>→ππ decay amplitudes. A clear signal with a 7.2σ statistical significance was later established with the full data samples from the NA31, E731, NA48 and KTeV experiments, confirming that CP violation is associated with a ΔS=1 quark transition, as predicted by the Standard Model. However, the theoretical prediction for the measured ratio ε'/ε has been a subject of strong controversy along the years...
May 1, 2018: Reports on Progress in Physics
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